Title:
MMP-12 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2001/083431
Kind Code:
A1
Abstract:
Compounds of the general formula (I), optical isomers or prodrugs of the same, pharmaceutically acceptable salts of them, or solvates thereof: (I) wherein R?1¿ is hydroxyl or the like; R?2¿ is optionally substituted lower alkyl or the like; R?3¿ is hydrogen or the like; R?4¿ is optionally substituted arylene or the like; R?5¿ is -C$m(Z)C- or the like; and R?6¿ is optionally substituted naphthyl or the like.
Inventors:
HORI YOZO (JP)
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
FURUE SHINGO (JP)
TAMURA YOSHINORI (JP)
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
FURUE SHINGO (JP)
TAMURA YOSHINORI (JP)
Application Number:
PCT/JP2001/003438
Publication Date:
November 08, 2001
Filing Date:
April 23, 2001
Export Citation:
Assignee:
SHIONOGI & CO (JP)
HORI YOZO (JP)
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
FURUE SHINGO (JP)
TAMURA YOSHINORI (JP)
HORI YOZO (JP)
WATANABE FUMIHIKO (JP)
TSUZUKI HIROSHIGE (JP)
FURUE SHINGO (JP)
TAMURA YOSHINORI (JP)
International Classes:
A61P11/00; A61P43/00; C07C311/19; C07C311/29; C07C311/46; C07C323/58; C07D209/20; C07D257/04; C07D271/06; C07D271/107; C07D333/34; C07D271/10; (IPC1-7): C07C311/19; A61K31/198; A61K31/357; A61K31/36; A61K31/381; A61K31/405; A61K31/41; A61K31/4245; A61K31/4709; A61P11/00; A61P43/00; C07C311/29; C07C311/45; C07C323/58; C07D209/20; C07D257/04; C07D271/06; C07D271/10; C07D317/56; C07D319/18; C07D333/34; C07D405/12; C07D409/06; C07D409/12; C07D409/14; C07D413/12
Domestic Patent References:
| WO2000051993A2 | 2000-09-08 | |||
| WO2000051975A1 | 2000-09-08 | |||
| WO2000063194A1 | 2000-10-26 | |||
| WO1999042443A1 | 1999-08-26 | |||
| WO1998032748A1 | 1998-07-30 | |||
| WO2000071506A2 | 2000-11-30 | |||
| WO1999012916A1 | 1999-03-18 | |||
| WO1997045402A1 | 1997-12-04 |
Foreign References:
| JPH1135557A | 1999-02-09 | |||
| JPH10204059A | 1998-08-04 | |||
| EP0658559A1 | 1995-06-21 | |||
| EP0757037A2 | 1997-02-05 | |||
| JPS63113455A | 1988-05-18 | |||
| JPS61236773A | 1986-10-22 | |||
| JPS5759969A | 1982-04-10 |
Other References:
CORRIE, JOHN E.T. ET AL.: "Synthesis and evaluation of photolabile sulfonamides as potential reagents for rapid photorelease of neuroactive amines", J. CHEM. SOC. PERKIN. TRANS., vol. 1, pages 1583 - 1592, XP002962039
See also references of EP 1288199A4
See also references of EP 1288199A4
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Intellectual Property Department 12-4,
Sagisu 5-chome, Fukushima-k, Osaka-shi Osaka, JP)
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