Title:
MODEL ANIMAL FOR BIPOLAR DISORDER
Document Type and Number:
WIPO Patent Application WO/2021/049497
Kind Code:
A1
Abstract:
The present invention provides a nonhuman model animal for bipolar disorder, in which the expression of Teneurin-4 protein is reduced in the prefrontal cortex. The present invention also provides a method for creating a nonhuman model animal for bipolar disorder, the method including reducing the expression of Teneurin-4 protein in the prefrontal cortex.
Inventors:
NITTA ATSUMI (JP)
TOKORO KAZUKI (JP)
TOKORO KAZUKI (JP)
Application Number:
PCT/JP2020/033988
Publication Date:
March 18, 2021
Filing Date:
September 08, 2020
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION UNIV OF TOYAMA (JP)
International Classes:
C12N15/113; A01K67/027; C12Q1/02
Domestic Patent References:
| WO2015153760A2 | 2015-10-08 |
Other References:
MIYASHITA, M. ET AL.: "Study of Teneurin-4 function to establish the bipolar disease mice model using CRISPR-Cas9 system", 2017, pages 1ยง57, Retrieved from the Internet
KATO, TADAFUMI: "How much did you know the cause of bipolar disorder?", PHARMA MEDICA, vol. 31, no. 3, 2013, pages 9 - 12
SKLAR, P. ET AL.: "Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4", NATURE GENETIC S, vol. 43, no. 10, 2011, pages 977 - 983, XP055217736, DOI: 10.1038/ng.943
IKEDA M, TAKAHASHI A, KAMATANI Y, OKAHISA Y, KUNUGI H, MORI N, SASAKI T, OHMORI T, OKAMOTO Y, KAWASAKI H, SHIMODERA S, KATO T, YON: "A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder", MOLECULAR PSYCHIATRY, vol. 23, no. 3, 2018, pages 639 - 647, XP055806248
KATO, TADAFUMI: "How much did you know the cause of bipolar disorder?", PHARMA MEDICA, vol. 31, no. 3, 2013, pages 9 - 12
SKLAR, P. ET AL.: "Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4", NATURE GENETIC S, vol. 43, no. 10, 2011, pages 977 - 983, XP055217736, DOI: 10.1038/ng.943
IKEDA M, TAKAHASHI A, KAMATANI Y, OKAHISA Y, KUNUGI H, MORI N, SASAKI T, OHMORI T, OKAMOTO Y, KAWASAKI H, SHIMODERA S, KATO T, YON: "A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder", MOLECULAR PSYCHIATRY, vol. 23, no. 3, 2018, pages 639 - 647, XP055806248
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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