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Patent Searching and Data


Title:
MODEL
Document Type and Number:
WIPO Patent Application WO/2003/017197
Kind Code:
A2
Abstract:
A model structure of IIIb of the hepatitis C virus internal ribosome entry site has been elucidated. The invention provides an $i(in silico) methods for identifying a compound that interacts with IIIb. Suitable methods include $i(de novo) compound design, use of the pharmacophore, and automated docking algorithms. Uses of compound/s identified are also described.

Inventors:
Aboul-ela, Fareed (Ribo Targets Limited, Granta Park Abington, Cambridge CB1 6GB, GB)
Klinck, Roscoe (Ribo Targets Limited, Granta Park Abington, Cambridge CB1 6GB, GB)
Gallego, Jose (MRC Laboratory of Molecular Biology, Structural Studies Division Hills Road, Cambridge CB2 2QH, GB)
Varani, Gabriele (The Department of Chemistry, University of Washington Box 35170, Seattle WA, 98195-1700, US)
Walker, Stephen (Ribo Targets Limited, Granta Park Abington, Cambridge CB1 6GB, GB)
Application Number:
PCT/GB2002/003767
Publication Date:
February 27, 2003
Filing Date:
August 13, 2002
Export Citation:
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Assignee:
RIBO TARGETS LIMITED (Granta Park, Abington, Cambridge CB1 6GB, GB)
Aboul-ela, Fareed (Ribo Targets Limited, Granta Park Abington, Cambridge CB1 6GB, GB)
Klinck, Roscoe (Ribo Targets Limited, Granta Park Abington, Cambridge CB1 6GB, GB)
Gallego, Jose (MRC Laboratory of Molecular Biology, Structural Studies Division Hills Road, Cambridge CB2 2QH, GB)
Varani, Gabriele (The Department of Chemistry, University of Washington Box 35170, Seattle WA, 98195-1700, US)
Walker, Stephen (Ribo Targets Limited, Granta Park Abington, Cambridge CB1 6GB, GB)
International Classes:
G06N3/00; (IPC1-7): G06N3/00
Attorney, Agent or Firm:
Maschio, Antonio (D Young & Co, 21 New Fetter Lane, London EC4A 1DA, GB)
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Claims:
CLAIMS
1. A method for identifying a compound that interacts with IIIb of the hepatitis C virus IRES, comprising the steps of : (a) providing atomic coordinates of IIIbau. pdb or IIIbca. pdb, or fragments or variants thereof; and (b) generating a structural model of the IRES using said coordinates; and (c) screening one or more in silico compound library/s and identifying one or more compound/s which interact with the structural model generated in step (b).
2. A method for identifying a compound that interacts with IIIb of the hepatitis C virus IRES, comprising the steps of : (a) providing the atomic coordinates of IIIbau. pdb or IIIbca. pdb, or fragments, or variants thereof ; and (b) generating a structural model of the IRES comprising one or more binding surface/s using the coordinates; and (c) identifying one or more functional group/s and/or small molecule fragment/s which are capable of interacting with the one or more binding surfaces identified in step (b); and (d) linking the one or more functional group/s and/or fragment/s identified in step (c) to generate a de novo compound.
3. A method for identifying a compound that interacts with IIIb of the hepatitis C virus IRES, comprising the steps of : (a) providing the atomic coordinates of IIIbau. pdb or IIIb_ca. pdb, or variants or fragments thereof; and (b) generating a structural model of the IRES using said coordinates; and (c) identifying one or more feature/s which define a pharmacophore ; and (d) screening one or more in silico compound library/s to identify one or more compound/s which interact with the pharmacophore.
4. The method of any one of claims 1 to 3, wherein the atomic coordinates are those of (i) nucleotides G179, A180, G181, A182, A183, G184, A185, C186, C187, G188, C189, C190, G207, G208, C209, G210, C211, U212, C213, U214, A215, U216, G217, C218, U219, C220 of IIIb_au. pdb, or (ii) nucleotides G179, A180, G181, A182, C183, G184, A185, C186, C187, G188, C189C190, G207, G208, C209, G210, C211, U212, C213, A214, A215, U216, G217, C218, U219, C220 of I I Ib ca. pdb.
5. A method according to any one of claims 1 to 4 wherein at least one step is computer implemented.
6. A method according to any one of claims 1 to 5, wherein the structural model defined in step (b) is obtained using molecular modelling techniques.
7. A method according to claim 6 wherein the molecular modelling techniques are implemented using computer software.
8. A method according to claim 7 wherein the computer software is selected from the group consisting of CERIUS, SYBYL, AMBER, HYPERCHEM, INSIGHT II, CATALYST, CHEMSITE, QUANTA and CHARM.
9. A method according to claim 2 or claims 4 to 8 wherein step (c) (identifying one or more functional group/s and/or small molecule fragment/s) is implemented using computer based techniques.
10. A method according to claim 9, wherein the computer based techniques are gridbased techniques and/or multiple copy simultaneous search (MCSS) methods.
11. A method according to claim 2 wherein step (d), (linking the one or more functional group/s and/or fragment/s identified in step (c) ) is performed using computer software selected from the group consisting of : QUANTA, SYBYL, HOOK and CAVEAT.
12. A method according to any one of claims 2, and 4 to 8 wherein step (d) ( (linking the one or more functional group/s and/or fragment/s identified in step (c) ) is performed manually.
13. A method according to claim 3 wherein step (c) (identifying a pharmacophore) is implemented using computer based techniques.
14. A method according to claim 13, wherein the computer based techniques involve the use of the software CATALYST and/or CERIUS.
15. A method according to claim 3, wherein step (c) (identifying a pharmacophore) is performed manually.
16. A method according to claim 1 wherein the docking algorithms described in step (c) are selected from the group of computer software consisting of : DOCK, AUTODOCK, MOE DOCK and FLEXX.
17. A compound identifyable using the method of any preceding claim.
18. A computer readable medium for a computer, characterised in that the medium contains the atomiccoordinates oflllbau. pdb or IIIB ca. pdb, and/or variants, and/or fragments thereof.
19. An assay for identifying a drug which binds to HCV IRES RNA, or variants, or fragments thereof, by monitoring the displacement of a reporter molecule designed by the methods of any one of claims 1 to 16, from the IRES RNA or variants, or fragments thereof.
20. A reporter molecule designed by the method of any one of claims 1 to 16, which is capable of binding to the HCV IRES RNA, or variants, or fragments thereof.
Description:
Model This invention is in the field of in silico screening, more particularly the use of in silico methods to identify compounds that bind to the sub-domain IIIb of the hepatitis C virus genome IN SILICO screening.

Cap-independent translation of hepatitis C virus (HCV) genomic RNA is mediated by an internal ribosome entry site (IRES) within the 5'-UTR of the viral RNA, and inhibiting the interaction of translation initiation factors with the 5'-UTR has been proposed as a therapeutic strategy [e. g references 1,2 and 3) Figure 1 shows the secondary structure of the 5'-UTR, which is divided into four major structural domains. Domains II, III and IV contribute to IRES translational activity, and are further sub-divided into stem-loops (e. g. IIa, IIb etc.). No atomic resolution data concerning the tertiary structure of the IRES is presently available.

The present invention concerns sub-domain IIIb (nucleotides 179-188 and 209-220), which has been reported as critical for IRES folding and function, and for binding of eIF3 [RiboTargets patent, ( (Sizova et al., 1998 ; Buratti et al., 1998). Though the sequence is not highly conserved, the overall secondary structure is conserved between the various HCV genotypes. IIIb is thus proposed as a drug target, and it is an object of the invention to facilitate the in silico identification and design of compounds that interact with IIIb, with a view to inhibiting IRES-mediated translation.

Summary of the invention The invention is based on the elucidation of a model structure of IIIb, generated using nuclear magnetic resonance (NMR) data. This contains distinct structural motifs, and is readily applicable to in silico drug design.

In a first aspect, the present invention provides a method for identifying a compound that interacts with IIIb of the hepatitis C virus IRES, comprising the steps of :

(a) providing the atomic co-ordinates of IIIb-au. pdb or IIIbca. pdb, or fragments or variants thereof; and (b) generating a structural model of the IRES using said co-ordinates; and (c) screening one or more in silico compound library and identifying one or more compound/s which interact with the structural model generated in step (b).

Preferably, step (c) may be computer implemented and/or involve the use of automated docking algortithms. The atomic co-ordinates of IIIb-au. pdb are provided in appendix I and the co-ordinates of IIIbca. pdb are provided in appendix II, In a further aspect, the present invention provides a method for identifying a compound that interacts with IIIb of the hepatitis C virus IRES, comprising the steps of : (a) providing the atomic co-ordinates of IIIb-au. pdb or IIIbca. pdb, or variants or fragments thereof ; and (b) generating a structural model of the IRES comprising one or more binding surface/s using the co-ordinates; and (c) identifying one or more functional group/s and/or small molecule fragments which are capable of interacting with the one or more binding surfaces identified in step (b); and (d) linking the one or more functional group/s and/or fragments thereof, identified in step (c) to generate a de novo compound.

In a further aspect, the present invention provides a method for identifying a compound that interacts with IIIb of the hepatitis C virus IRES, comprising the steps of : (a) providing the atomic co-ordinates of IIIb-au. pdb or IIIb_ca. pdb, or variants or fragments thereof; and (b) generating a structural model of the IRES using said co-ordinates; and (c) identifying one or more feature/s which define a pharmacophore; and

(d) screening one or more in silico compound library/s to identify one or more compounds which interact with the pharmacophore Those'features which define a pharmocophore'in the context of the present invention means those chemical features and/or 3D restraint/s which expresses characteristic/s of the IRES responsible for its'biological activity.

The invention involves the use of atomic co-ordinates of IIIb. These may be co-ordinates for the complete subdomain IIIb (nucleotides 179-188 and 209-220) they may be co-ordinates for a fragment of the IRES that comprises IIIb, or they may be co-ordinates for a fragment of IIIb. Atomic co-ordinates for use according to the invention are IIIbau. pdb and IIIbca. pdb, as set out herein. Both these co-ordinate sets represent the 30mer IIIb construct. The two sets are for the two most common polymorphic IIIb sequences found in nature, and were determined by NMR in combination with computational methods.

Variants of IIIb_au. pdb and IIIbca. pdb can also be used for the invention, such as variants in which the r. m. s. deviation of the x, y and z co-ordinates are all less than 2. 5A compared with the structures given herein, or variants in which all coordinates have been translated or rotated in an identical manner, such that the relative spatial relationship of the individual atoms remains the same. An ensemble of coordinates for the CA variant is also included IIIbcaens. pdb.

Two preferred fragments of IIIb whose co-ordinates can be used in the invention are : - the internal loop (nucleotides G181, A182, C183, G184, C218, G217, U216, A215, A214, C213 ("CA variant) or G181, A182, A183, G184, C218, G217, U216, A215, U214, C213 ("AU variant") ) - the C*C mismatch (nucleotides G184, A185, C186, C187, G210, C211, U212, C213).

Functional data indicates that eIF3 binding and translational activity is dependent upon elements found within both the C*C fragment and the internal loop. A more preferred fragment of IIIb whose co-ordinates can be used according to the invention thus

comprises both of these fragments (i. e. nucleotides G179, A180, G181, A182, C183 (A183), G184, A185, C186, C187, G188, C189, C190, G207, G208, C209, G210, C211, U212, C213, A214 (U214), A215, U216, G217, C218, U219, C220), as their juxtaposition is less likely to be present also in human RNA.

In the above aspects of the invention, preferably the structural model of the IRES is generated using molecular modelling techniques. Advantageously these are computer implemented modelling techniques. Suitable programs include grid-based techniques and/or multiple copy simultaneous search (MCSS) methods. These are described herein, and will be familiar to those skilled in the art. Alternatively, visual inspection of a computer model of IIIb can be used, in association with manual docking of models of functional groups into its binding pockets.

Once a structural model has been generated as herein described, compounds may for example be identified by one or more of the following techniques: de novo compound design, by defining a pharmacophore as herein defined, and/or by using automated docking algorithms as herein described.

In the first aspect (de novo compound design) step (d), (linking the one or more functional group/s and/or fragment/s identified in step (c) ) maybe performed using suitable computer software. In a preferred embodiment of this aspect of the invention, the software is selected from the group consisting of : QUANTA, SYBYL, HOOK and CAVEAT. Alternatively, linking the functional groups may be performed manually.

Suitable in silico libraries for use in the methods of the present invention will be familiar to those skilled in the art, and includes the Available Chemical Directory (MDL Inc), the Derwent World Drug Index (WDI), BioByteMasterFile, the National Cancer Institute database (NCI), and the Maybridge catalog.

In a further aspect, the present invention provides a compound identifyable using one or more of the methods of the present invention In a further aspect still, the present invention provides a computer readable medium for a computer, characterised in that the medium contains the atomic-co-ordinates of IIIbau. pdb or IIIBca. pdb, or variants, or fragments thereof.

In a further aspect, the present invention provides an assay for identifying a drug which binds to HCV IRES RNA, or variants, or fragments thereof, by monitoring the displacement of a reporter molecule designed by any one of the methods of the present invention, from the IRES RNA or variants, or fragments thereof.

In a final aspect, the present invention provides a reporter molecule designed by any one of the methods of the present invention, which is capable of binding to the HCV IRES RNA, or variants, or fragments thereof.

Brief Description of the figures Figure 1 shows the HCV IRES, including secondary structural motifs. IIIb is enlarged and boxed.

Figure 2 shows a portion of the NMR spectrum of the AU variant of loop IIIb, highlighting the"box pattern"of NOEs indicative of inversion of orientation of the sugar residue corresponding to A215.

Figure 3 Shows examples of putative base pairing schemes.

Figure 4 Shows an example of a calculated structure of the AU variant of HCV loop IIIb, which shows consistency with the NMR data and predictions based upon existing databases of RNA structures Figure 5 Shows a superposition of the 13 lowest energy calculated structures of the CA sequence variant (a), based upon residues (A214, A215, U216, G217, C218, U219,

C220, G179, A180, G181, A182, C183 and tetraloop residues), and an example of one low energy calculated structure (b). The superposition was obtained by superimposing residues C183 to A214, or in the original 30 base numbering scheme, A8 to C23. This includes the internal loop, upper stem and tetraloop.

Figure 6 shows a diagram illustrating the theoretical arguments postulated to explain the predominance of head to head GA base pairing within the context of sequences similar to IIIb.

Detailed Description of the invention The present invention concerns sub-domain IIIb (nucleotides 179-188 and 209-220), which has been reported as critical for IRES folding and function, and for binding of eIF3 [iv, v, vi]. Though the sequence is not highly conserved, the overall secondary structure is conserved between the various HCV genotypes. IIIb is thus proposed as a drug target, and it is an object of the invention to facilitate the in silico identification and design of compounds that interact with IIIb, with a view to inhibiting IRES-mediated translation.

The storage medium The storage medium in which the atomic co-ordinates are provided is preferably random-access memory (RAM), but may also be read-only memory (ROM e. g.

CDROM), or a diskette. The storage medium may be local to the computer, or may be remote (e. g. a networked storage medium, including the internet).

The invention also provides a computer-readable medium for a computer, characterised in that the medium contains atomic co-ordinates of the IIIb loop of the hepatitis C virus IRES. The atomic co-ordinates are preferably IIIbau. pdb or IIIbca. pdb, (as herein described) or variants thereof. Any suitable computer can be used in the present invention.

Molecular modelling techniques Molecular modelling techniques can be applied to the atomic coordinates of the IIIb structure to derive a range of 3D models and to investigate the structure of ligand binding sites. A variety of molecular modelling methods are available to the skilled person for use according to the invention [e. g. ref. i].

At the simplest level, visual inspection of a computer model of IIIb can be used, in association with manual docking of models of functional groups into its binding pockets.

Software for implementing molecular modelling techniques may also be used. Typical suites of software include CERIUS2 [ii], SYBYL [iii], AMBER [vii], HYPERCHEM [viii], INSIGHT II [ii], CATALYST [ii], CHEMSITE [vii], QUANTA [ii]. These packages implement many different algorithms that may be used according to the invention (e. g. CHARMm molecular mechanics [vii] ). Their uses in the methods of the invention include, but are not limited to: (a) interactive modelling of the structure with concurrent geometry optimisation (e. g. QUANTA); (b) molecular dynamics simulation of the IIIb structure (e. g. CHARMM, AMBER) ; (c) normal mode dynamics simulation of the IIIb structure (e. g. CHARMM/AMBER).

Modelling may include one or more steps of energy minimisation with standard molecular mechanics force fields, such as those used in CHARMM and AMBER.

These molecular modelling techniques allow the construction of structural models that can be used for in silico drug design and modelling.

Some algorithmic techniques listed above are conventionally used for modelling ligand-protein interactions, but can be modified for modelling ligand-RNA interactions for use according to the present invention.

de novo compound design The molecular modelling steps used in the methods of the invention may use the atomic co-ordinates of IIIb, and models derived therefrom, to determine binding surfaces. This preferably reveals van der Waals contacts, electrostatic interactions, and/or hydrogen bonding opportunities.

These binding surfaces will typically be used by grid-based techniques (e. g. GRID [xi], CERIUS2) and/or multiple copy simultaneous search (MCSS) techniques [xii] to map favourable interaction positions for functional groups. This preferably reveals positions in IIIb for interaction such as but not limited to those with protons, hydroxyl groups, amine groups, hydrophobic groups such as methyl, ethyl, benzene, and/or divalent cations.

Once functional groups or small molecule fragments which can interact with specific sites in the binding surface of IIIb have been identified, they can be linked in a single compound using either bridging fragments with the correct size and geometry or frameworks which can support the functional groups at favourable orientations, thereby providing a compound according to the invention. Whilst linking of functional groups in this way can be done manually, perhaps with the help of software such as QUANTA or SYBYL, the following software may be used for assistance: HOOK [ii], which links multiple functional groups with molecular templates taken from a database, and/or CAVEAT [xiii], which designs linking units to constrain acyclic molecules.

Other computer-based approaches to de novo compound design that can be used with the IIIb atomic co-ordinates include LUDI [xiv, ii], SPROUT [xv] and LEAPFROG [iii].

Pharmacophore searching As an alternative to de novo design, a pharmacophore of the IIIb loop can be defined i. e. a collection of chemical features and 3D constraints that expresses specific

characteristics responsible for biological activity. The pharmacophore preferably includes surface-accessible features, more preferably including hydrogen bond donors and acceptors, charged/ionisable groups, and/or hydrophobic patches. These may be weighted depending on their relative importance in conferring activity [xviii] Pharmacophores can be determined using software such as CATALYST (including HypoGen or HipHop) [ii], CERIUS2, or constructed by hand from a known conformation of a lead compound. The pharmacophore can be used to screen in silico compound libraries, using a program such as CATALYST [ii].

Suitable in silico libraries includes the Available Chemical Directory (MDL Inc), the Derwent World Drug Index (WDI), BioByteMasterFile, the National Cancer Institute database (NCI), and the Maybridge catalog.

Docking Compounds in these in silico libraries can also be screened for their ability to interact with IIIb by using their respective atomic co-ordinates in automated docking algorithms. Suitable docking algorithms include: DOCK [xvii], AUTODOCK [xviii, vii], MOE-DOCK [xix] or FLEXX [iii]. Docking algorithms can also be used to verify interactions with ligands designed de novo.

Homology models The eIF3 protein, which consists of up to ten subunits, has been shown to interact with portions of the IRES which encompass IIIb.

1. The structure of IIIb may provide some clues as to which of these subunits contact the IIIb region of the IRES. A number of known structures of RNA substrates of RNA binding proteins bear some resemblance to the structure of IIIb RNA observed here For example, the 1360 loop in the 30S rRNA crystal structure [xx] contains bases which are structurally analogous to nucleotides G181, A182, and A215

to C218 of IIIb. This loop interacts with ribosomal proteins S9, S10, S14 and the THX peptide. Another example can be found in the 50S crystal structure [xxi], where the internal loop containing A247 has sequence similarities to the IIIb internal loop. This loop interacts intimately with ribosomal proteins L7AE and L15E, although the internal loop base pairings differ significantly from those observed in IIIb. Searching for sequence homologies between these proteins and the individual subunits of eIF3 may provide some clues as to which subunit (s) contact the IIIb internal loop.

2. To design a reporter for a displacement assay for the identification of ligands binding to HCV sub-domain IIIb. If one of the naturally occurring proteins, or some peptide segment of such proteins, can be shown to bind to HCV IIIb, an assay can be developed for the interaction, using, for example, FRET, chemical footprinting, or retardation of mobility in gel electrophoresis. Compounds produced through a drug discovery program could then be assayed for their ability to disrupt the protein-RNA interaction, as an indication of their binding to HCV IIIb.

3. To design libraries of compounds for a drug discovery program targeted at binding to HCV IIIb. The proteins in question or derivative peptides may not have the optimal properties to be used as drugs. However, if the structure of the complex of such a protein with the substrate RNA is known then elements from within the protein which interact with the RNA could be mimicked by the compound library designed with knowledge of said structure.

In either case, the coordinates claimed here can be used to perfect the design in the following way: The designed reporter or compound is docked against the HCV IIIb coordinates claimed herein, by analogy with the interaction observed in the known crystal or NMR structure. Fragments and/or functional groups from the protein which could be used to design a low molecular weight compound are identified, as well as possible contacts or clashes with other parts

of the IIIb RNA. The reporter or ligand is then designed to alleviate steric or electrostatic clashes, reduce the molecular weight, improve pharmacological properties, or to add favourable interactions by means described elsewhere under modelling strategies. The"reporters or ligands"could be fragments from a protein, organic molecules containing the critical functional groups, or "antisense"ligands, i. E. , oligonucleotides, PNAs, etc.

'Dual site'design Testing compounds The methods of the invention may comprise the further steps of (c) providing a compound identified by the methods of the present invention; and (d) contacting said compound with the HCV IRES and assaying the interaction between them.

Suitable methods for assaying the interaction between the HCV IRES and the compound include: (i) the direct methods disclosed in iv ; (b) the indirect methods disclosed therein. Preferred indirect methods use bicistronic constructs containing two different luciferases, the first being translated in a cap-dependent manner and the second being translated from the HCV IRES in a cap-independent manner. The relative levels of the two luciferases gives an indication of whether the IRES-mediated translation was inhibited.

Compounds and their uses The methods of the invention identify compounds that can interact with IIIb of the hepatitis C virus IRES. These compounds may be designed de novo, may be known compounds, or may be based on known compounds.

The invention also provides: (i) a compound identified using the methods of the invention; (ii) a compound identified using the methods of the invention for use as a pharmaceutical ; (iii) the use of a compound identified using the methods of the invention in the manufacture of a medicament for treating hepatitis C infection; and

(iv) a method of treating a patient with hepatitis C infection, comprising administering an effective amount of a compound identified using the methods of the invention.

Examples Example 1 Mutational analysis of IIIb Substitution mutants of IIIb were created using oligonucleotide site-directed mutagenesis using the Stratagene QuickChange Kit. The mutations, the procedures for creating and testing them, and the results, are detailed in [iv].

Example 2 Modelling the IIIb structure NMR spectra Two 30 nucleotide oligomers which incorporated the IIIb internal loop and C. C oppostion were transcribed using DNA template driven T7 RNA polymerase. The sequences are shown in Figure 1. These sequences represent the two most common HCV IRES genotypes in this region, and are referred to as the CA variant and AU variant (nucleotide positions 183 and 214). A UUCG tetraloop was inserted in the sequences to simplify the synthesis and analysis by joining the two helical strands. The following is the protocol used for the preparation of NMR samples of both unlabeled and uniformly 13C/l5N labeled AU variant sequences. The CA variant sequences were prepared separately, using a similar protocol. Transcripts were purified by polyacrylamide gel electrophoresis under denaturing conditions, excised and electroeluted as described [xxii]. The RNA was then dialysed for 12 to 24 hours consecutively against each of the following: 1. 1M NaCl, 5mM EDTA and lOmM sodium phosphate pH 6 2. 500mM NaCI, 1mM EDTA 10 mM phosphate pH6 3. 50mM NaCI (for the AU variant only), O. 1mM EDTA lOmM phosphate pH 6

4. H20 After the final dialysis against water, the transcripts were further purified by size exclusion on a NAP-10 column (Pharmacia), adjusted to the desired final pH with dilute NaOH, and lyophilised to dryness. Samples were then taken up in 280ul Ha0 containing 10% D2O, and placed in low volume, susceptibility matched NMR tubes (Shigemi) for analysis. The final concentration of the NMR samples was 1mM RNA.

For experiments run in 100% D20, the samples were lyophilised twice in the NMR tube into D20.

All NMR spectra were recorded on a Bruker DRX600 spectrometer equipped with a 4 channel H/P/C/N, z-gradient probe (AU variant), a DRX 500 Mhz, DMX 600 Mhz or DRX 800 MHz with an H/C/N triple resonance, z gradient probe, . Analysis of exchangeable protons was done in 90% H20 10% D20 using a flip-back watergate sequence for water suppression. One-dimensional spectra were run at 278K at various pH values. NOESY experiments were run on the unlabeled sample at 278K and 300K at pH 6, with 60ms and 150ms mixing times (AU variant), or at 70,140 and 220 ms (CA variant).

Analysis of the non exchangeable protons of the unlabeled samples was done in Da0 at 300K, pH 6. Double quantum filtered COSY, TOCSY, NOESY (60ms, 120ms and 400ms mixing times) and IH-3lP HETCOR spectra were recorded. Datasets were acquired at pH 6 and pH 7 using a uniformly 15N/l3C labeled sample.'H-13C HSQC spectra were recorded at 290K, 300K and 308K. HCCH-COSY and HCCH-TOCSY spectra were acquired both pH values at 290K and 300K. A carbon edited NOESY- HSQC experiment, with a mixing time of 250ms, was acquired at 290K, pH 7, and at pH 6,300K with mixing times of 120ms and 200ms. A 3D-HCP experiment was acquired at 300K, pH6. HNNCOSY experiments were recorded at pH 6 at 308K and at pH 7 at 290K. The latter were repeated with deuterium decoupling using the CA variant. Proton chemical shifts were referenced to the residual water peak at 4.77 ppm at 298K. Carbon, phosphorus and nitrogen resonances were referenced to according to

their offset from the base frequencies of 150.902749 MHz, 242.936777 MHz and 60.810663 respectively, relative to a proton value of 600.13 MHz.

Example 3 Structure calculations for the CA variant Distance constraints between non-exchangeable protons were automatically obtained using Felix 97 from 800 MHz 2D NOESY volume build-ups at 70,140 and 220 ms mixing times, using the cross-peaks corresponding to the covalently constrained cytosine H5-H6 distances as a reference. The constraints were assigned upper limits of 3.5, 4.5 and 6 A depending on the value of the predicted interproton distances.

Restraints involving ambiguous or overlapped cross-peaks we obtained from the 13C- edited NOESY-HMQC spectra at 100 and 200 ms mixing times. Interproton distances derived from NOE cross-peaks involving exchangeable resonances were given a single generous upper limit of 5 to 6 A.

Hydrogen bonding distance constraints for Watson-Crick pairs were introduced based on the results of the HNN experiments (for A: U pairs), and/or when a slow rate of exchange with solvent, a large downfield shift of NH resonances, and characteristic patterns of NOE interactions were observed in the H20 experiments. Very weak planarity restraints were also introduced to generate planar hydrogen bonds for Watson-Crick pairs. No hydrogen bonding restraints were used for the internal loop region.

The sugar conformation was deduced from analysis of 2QF-COSY spectra. For the backbone, conservative 0 d : 120° a and y dihedral angle restraints were introduced for the double helical parts of the structure, based on the observation of 3 1P chemical shift values and standard A-form NOE connectivities. The 5 angle is determined by the sugar pseudo-rotation angle, and p, y, and y were constrained in all residues using a combination of observations from NOESY, HCP, 2D and 3D HetCOR and TOCSY- HSQC experiments [xxiii].

Structure calculations by restrained molecular dynamics were performed using an X- PLOR-based simulated annealing protocol, which does not make any assumption about the geometry of the RNA. Attractive van der Waals and electrostatic interactions were introduced at the end of the calculation to obtain structures with improved covalent geometry and electrostatics. 50 random starting structures were generated and after simulated annealing 13 of these defined the ensemble on which the description of the structure is based. Selection of converged structures was unbiased and was done using energy-ordered rmsd profiles. Pseudo-energies of NOE violations and total energies are very low, indicating good convergence, and similar for the set of 13 converged structures Example 4 Data from NMR spectra U216 bulge The aromatic to anomeric protein NOE connectivity path in IIIb is broken between nucleotides A215 and G217, which show NOEs to each other (i. e. base stacking) in both directions (figure 2). A similar'box pattern'of NOEs can arise where alternating anti and syn glycosidic angles are present, as in Z-DNA [xiv] or'foldback'G-quartet structures [xxv]. In the absence of the diagnostic signals associated with syn glycosidic geometry, however, this pattern can only arise in IIIb from a localised backbone inversion at A215. This inversion is accommodated by, and dependent upon, the bulged-out nucleotide U216, indicated by U216 only presenting intranucleotide cross- peaks.

The presence of a locally inverted nucleotide 5'to a bulged-out nucleotide has been reported in several structures, including the RRE [xxvi] and the loop E motif of the sarcin/ricin loop.

Conclusions from NMR Data and a Brief description of the Coordinate Structure Overall, under these conditions, there are no unassigned imino, amino or aromatic resonances, the presence of which would indicate the formation of alternative or

unfolded structures, although some evidence of dynamics is visible in other pH ranges.

In isolation, the 30mer IIIb fragment thus forms a stable secondary structure, which is likely to be maintained within the context of the full HCV 5'-UTR.

Overview of IIIb structure i). The C186-C211 apposition are intercalated into the helix; they are likely to form more than one base pair in conformational exchange. ii). A183-U214 in the AU variant forms a Watson-Crick pair. In the CA variant the C183-A215 forms a pair with a two hydrogen bonds that closely resembles a Watson- Crick pair. iii). The conformation of A215-U216 and A217/G is identical in both variants. A215 and U216 have 2'-endo sugar pucker. Distinctive NOEs between A215 and G217 were observed that supported a reverse sugar conformation for A215, as as discussed above.

Although U216 is bulged out, it can be mutated without loss of IRES function.

Presumably, it is a spacer needed to create the right loop conformation. iv). The A182-G217 opposition forms a"head to head"base pair (Figure 3). A182 stacks on the G181-C218 pair, as does G217.

Structure determination and non Watson Crick pairing Full datasets included tH, 13 C-'H, 15N-'H, and 31P-IH spectra, and resonance assignments were extended to include virtually all sugar proton, aromatic and sugar carbon, nitrogen and some phosphorus resonances, for the AU variant, and an even more complete assignment set for the CA variant. The structure of the CA variant was determined solely from NOE data and dihedral angle restraints, while the AU variant structure was also modelled using idealised A-form duplex restraints in the Watson Crick paired regions. Imino to N1/N3 hydrogen bonding was detected directly through nitrogen-nitrogen couplings for all of the corresponding Watson-crick base pairs in these domains, except for the A185/U212 opposition (discussed below). Calculations were carried out using the program XPLOR according to standard methods [xxiii].

Structures of the AU variant were further minimised gently using CHARMM including the full 25.2 forcefield to test the stability of the structure in the presence of electrostatic and van der Waals forces. The CA variant structure also underwent a final round of minimisation in the presence of full potential forcefields, in this case within XPLOR.

A structure of the AU variant is shown in figure 4a. The s-turn in the backbone between A215 and G217 is highlighted, as is a head to head base pair between G217 and A182 (figure 3). The latter is not observed when the structure is calculated based on NOE data alone, but calculating the structure with the base pair constrained to be present results in no penalties in terms of energies or violations of experimental restraints. Since there is no signal present from the imino proton of G 217, it was very difficult to determine the position of the corresponding base moiety. Given that the NOE data indicates that both A182 and G217 are in anti conformation and stacked on the G181 : C218 pair, a theoretical argument can be invoked to predict the base pairing geometry. Of the two known pairing geometries, sheared and head-to-head (figure 3), only the head to head is possible in this context. This is based on the cross strand distances between phosphorus atoms in the intervening phosphates of consecutive base pairs, as described in figure 6.

An ensemble of XPLOR-calculated structures for the CA variant (figure 5a), from restraint lists compiled independently by, show a clear preference for the head to head G*A pair versus either unpaired or sheared pairing geometries (figure Sb). The observation of sequential connectivities (including H8-H6 and H8-H5 NOEs) for the G217-C218 step (Figure 3) indicates that G217 must be intra-helical. The orientation of the A182 base is well defined by the NOEs described above, and only weak or medium NOEs are observed between G217 Hl'and C218 H6 (Figure 3) and between G217 H2'and C218 H5. A weak NOE is also observed between A182 H2 and C183 H6. All these interactions exclude the possibility of sheared G: A pairing, and determined the spontaneous formation of a head-to-head G217: A182 pair between

these two residues during the calculations. The result can be extrapolated back to confirm the conclusion of head to head pairing for the AU variant, since chemical shift and NOE patterns in this region are virtually identical for the two constructs.

It was also not possible to determine hydrogen bonding involving putative C*A pairing in the CA variant directly from nitrogen nitrogen couplings. However, NOE restraint data was sufficient to constrain formation of a base pairing between C183 and A215. Amino groups from each moiety act as hydrogen bond donors, with the N3 and N1 of C173 and A215 respectively acting as acceptors (figure 3). A critical determinant of this base pairing geometry was the observation of an NOE at short mixing times between the H2 resonance of A214 and the H5 resonance of C183. A C183/A214 base pairing, predicted by analogy to the AU variant, could only have accommodated this result with a C amino donating a hydrogen to A N3. The latter scheme was not consistent with the NOE data.

It was not possible to form a definitive structural description for the C186-C211 opposition, aside from the qualitative indication of helical stacking referred to above.

At the pH range in which the full dataset was acquired, no signal could be assigned for the critical amino proton resonances. At pH 5, a broad signal at 15.4 ppm is observed which is diagnostic of a protonated C*C pair. However, at this pH there is evidence of multiple conformations of the RNA oligomer. A putative base pairing scheme without protonation, which is consistent with the data at pH 6, is also shown in figure 3.

All publications mentioned in the above specification, and references cited in said publications, are herein incorporated by reference. Various modifications and variations of the described methods and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention.

Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in molecular biology or related fields are intended to be within the scope of the following claims.

References i Further details: Rational drug design : novel methodology andpractical applications, ACS Symposium Series vol. 719 (Parrill & Reddy eds. , 1991). ii Available from Molecular Simulations Inc (http ://www. msi. com/) iii Available from Tripos Inc (http : //www. tripos. com) iv International (PCT) patent application no. PCT/GB00/04862, RiboTargets, Ltd. v Sizova, D. V. et al. 1998. Journal of Virology. 72: 4775-4782. vi Buratti, E. et al. 1998. Nucleic Acids Research. 26: 3179-3187. vii Available from Oxford Molecular (http ://www. oxmol. co. uk/) viii Available from Hypercube Inc (http://www. hyper. com/) ix Available from Pyramid Learning (http ://www. chemsite. org/) x e. g. Brooks et al. (1983) J : Comp. Chem. 4: 187-217. xi Goodford (1985) J. Med. Chem. 28: 849-857. xii Miranker & Karplus (1991) Proteins : Structure, Function and Genetics 11: 29-34. xiii Lauri & Bartlett (1994) Comp. Aided Mol. Design 8 : 51-66. xiv Böhm (1992) J. Comp. Aided Molec. Design 6: 61-78. xv Available from http ://chem. leeds. ac. uk/ICAMS/SPROUT. html. xvi also Computer-Assisted Lead Finding and Optimization (eds. Testra & Folkers, 1997) xvii Kuntz et al. (1982) J. Mol. Biol. 161: 269-288) ; available from UCSF. xviii Goodsell et al. (1990) Proteins : Structure, Function and Genetics 8 : 195-202 xix Available from Chemical Computing Group Inc. (http ://www. chemcomp. com/) xx Wimberly et al. Nature. 407: 327-339 xxi Ban, N et al. Science. 289 : 905-920. xxii Price, S. R. et al, in RNA. protein interactions. C. W. J. Smith, editor. oxford university press, Oxford. xxiii Varani, G. et al (1996). in. Progress in nuclear magnetic resonance spectroscopy.

29: 51-127. xxiv Wiithrich (1986) NMR ofproteins and nucleic acids. Wiley. xxv Smith & Feigon (1992) Nature 356: 164-68. xxvi Battiste et al. (1996) Science 273: 1547-1551.

Appendix I: Atomic co-ordinates: IIIb-au. pdb ATOM 1 H5T GUA 1 19.450-33. 350 17.729 1.00 0.00 strl ATOM 2 05'GUA 1 19. 217-33.806 18.541 1.00 0.00 strl ATOM 3 C5'GUA 1 19.901-35. 067 18.533 1.00 0.00 strl ATOM 4 H5'GUA 1 20.734-35. 024 19.222 1.00 0.00 strl ATOM 5 H5''GUA 1 20.276-35. 260 17.515 1.00 0.00 strl ATOM 6 C4'GUA 1 19.009-36. 214 18.995 1.00 0.00 strl ATOM 7 H4'GUA 1 19.482-37. 163 18.749 1.00 0.00 strl ATOM 8 04'GUA 1 18.772-36. 160 20.414 1.00 0.00 strl ATOM 9 C1'GUA 1 17.361-36. 281 20.669 1.00 0.00 strl ATOM 10 H1'GUA 1 17.193-36. 975 21.493 1.00 0.00 strl ATOM 11 N9 GUA 1 16.769-34. 971 20.990 1.00 0.00 strl ATOM 12 C4 GUA 1 15.508-34. 738 21.495 1.00 0.00 strl ATOM 13 N3 GUA 1 14.576-35. 679 21.776 1.00 0.00 strl ATOM 14 C2 GUA 1 13.445-35. 143 22. 251 1.00 0.00 strl ATOM 15 N2 GUA 1 12.415-35. 925 22.577 1.00 0.00 strl ATOM 16 HN'GUA 1 12. 486-36.926 22.467 1.00 0.00 strl ATOM 17 HN''GUA 1 11.564-35. 516 22.936 1.00 0.00 strl ATOM 18 Nl GUA 1 13.259-33. 790 22.431 1.00 0.00 strl ATOM 19 Hl GUA 1 12.373-33. 468 22.786 1.00 0.00 strl ATOM 20 C6 GUA 1 14.199-32. 806 22.153 1.00 0. 00 strl ATOM 21 06 GUA 1 13.935-31. 624 22.356 1.00 0.00 strl ATOM 22 C5 GUA 1 15. 402-33. 364 21.647 1.00 0.00 strl ATOM 23 N7 GUA 1 16.581-32. 730 21.245 1.00 0. 00 strl ATOM 24 C8 GUA 1 17.308-33. 732 20.883 1.00 0.00 strl ATOM 25 H8 GUA 1 18.320-33. 588 20.505 1.00 0.00 strl ATOM 26 C2'GUA 1 16.768-36. 846 19.393 1. 00 0. 00 strl ATOM 27 H2''GUA 1 15.716-36. 558 19.288 1.00 0.00 strl ATOM 28 02'GUA 1 16. 921-38. 270 19. 331 1.00 0.00 strl ATOM 29 H2'GUA 1 16.557-38. 632 20.143 1.00 0.00 strl ATOM 30 C3'GUA 1 17.624-36. 153 18.353 1.00 0.00 strl ATOM 31 H3'GUA 1 17.287-35. 130 18.166 1.00 0. 00 strl ATOM 32 03'GUA 1 17.595-36. 966 17.186 1.00 0.00 strl ATOM 33 P GUA 2 16.793-36. 485 15.877 1.00 0.00 strl ATOM 34 01P GUA 2 17.112-35. 062 15.626 1.00 0.00 strl ATOM 35 02P GUA 2 16.988-37. 493 14.810 1.00 0.00 strl ATOM 36 05'GUA 2 15.279-36. 584 16. 403 1.00 0.00 strl ATOM 37 C5'GUA 2 14. 638-37.849 16.544 1.00 0. 00 strl ATOM 38 H5'GUA 2 15.198-38. 463 17.236 1.00 0.00 strl ATOM 39 H5''GUA 2 14.608-38. 335 15.558 1.00 0.00 strl ATOM 40 C4'GUA 2 13.232-37. 723 17.105 1.00 0.00 strl ATOM 41 H4'GUA 2 12.751-38. 694 17.120 1.00 0.00 strl ATOM 42 04'GUA 2 13. 254-37. 188 18.437 1.00 0.00 strl ATOM 43 C1'GUA 2 12.089-36. 362 18.635 1.00 0.00 strl ATOM 44 H1'GUA 2 11.496-36. 765 19.455 1.00 0.00 strl ATOM 45 N9 GUA 2 12.433-34. 956 18.928 1.00 0.00 strl ATOM 46 C4 GUA 2 11. 561-33.992 19.376 1.00 0.00 strl ATOM 47 N3 GUA 2 10. 248-34. 177 19.632 1.00 0.00 strl ATOM 48 C2 GUA 2 9.650-33. 059 20.046 1.00 0.00 strl ATOM 49 N2 GUA 2 8.349-33. 067 20.331 1.00 0.00 strl ATOM 50 HN'GUA 2 7.817-33. 920 20.233 1.00 0.00 strl ATOM 51 HN''GUA 2 7.896-32. 223 20.640 1.00 0.00 strl ATOM 52 N1 GUA 2 10.303-31. 851 20. 198 1.00 0. 00 strl ATOM 53 H1 GUA 2 9.775-31. 046 20.505 1. 00 0.00 strl ATOM 54 C6 GUA 2 11.654-31. 636 19.945 1.00 0.00 strl ATOM 55 06 GUA 2 12.146-30. 524 20.123 1. 00 0. 00 strl ATOM 56 C5 GUA 2 12.296-32. 824 19.499 1.00 0.00 strl ATOM 57 N7 GUA 2 13. 628-33. 043 19.134 1.00 0.00 strl ATOM 58 C8 GUA 2 13.613-34. 296 18.818 1.00 0.00 strl ATOM 59 H8 GUA 2 14.508-34. 795 18.458 1.00 0. 00 strl ATOM 60 C2'GUA 2 11.293-36. 436 17.341 1.00 0.00 strl ATOM 61 H2"GUA 2 10.830-35. 474 17.135 1.00 0.00 strl ATOM 62 02'GUA 2 10.318-37. 485 17.380 1.00 0.00 strl ATOM 63 H2'GUA 2 10.445-37. 963 18.203 1.00 0.00 strl ATOM 64 C3'GUA 2 12.385-36. 726 16.333 1.00 0.00 strl ATOM 65 H3'GUA 2 12.943-35. 831 16.055 1.00 0.00 strl ATOM 66 03'GUA 2 11.803-37. 393 15.207 1.00 0.00 strl ATOM 67 P CYT 3 11.391-36. 591 13.866 1.00 0.00 strl ATOM 68 01P CYT 3 12.427-35. 566 13. 605 1.00 0.00 strl ATOM 69 02P CYT 3 11.059-37. 584 12.820 1.00 0.00 strl ATOM 70 05'CYT 3 10.031-35. 834 14.290 1.00 0.00 strl ATOM 71 C5'CYT 3 8.807-36. 569 14.367 1.00 0.00 strl ATOM 72 H5'CYT 3 8.911-37. 342 15.128 1.00 0.00 strl ATOM 73 H5''CYT 3 8.623-37. 046 13.405 1.00 0.00 strl ATOM 74 C4'CYT 3 7.605-35. 689 14.719 1.00 0. 00 strl ATOM 75 H4'CYT 3 6.692-36. 277 14.663 1.00 0.00 strl ATOM 76 04'CYT 3 7.728-35. 141 16.035 1.00 0.00 strl ATOM 77 C1'CYT 3 7. 172-33. 806 16.060 1.00 0.00 strl ATOM 78 H1'CYT 3 6.393-33. 745 16.821 1.00 0.00 strl ATOM 79 N1 CYT 3 8.212-32. 789 16.312 1.00 0.00 strl ATOM 80 C6 CYT 3 9.527-33. 068 16.096 1.00 0.00 strl ATOM 81 H6 CYT 3 9.811-34. 048 15.725 1. 00 0.00 strl ATOM 82 C2 CYT 3 7.798-31. 532 16.728 1.00 0.00 strl ATOM 83 02 CYT 3 6.603-31. 304 16. 911 1.00 0.00 strl ATOM 84 N3 CYT 3 8.744-30. 572 16.922 1.00 0.00 strl ATOM 85 C4 CYT 3 10.041-30. 833 16.718 1.00 0.00 strl ATOM 86 N4 CYT 3 10.943-29. 872 16.920 1.00 0.00 strl ATOM 87 HN'CYT 3 10.645-28. 957 17.224 1.00 0.00 strl ATOM 88 HN"CYT 3 11.923-30. 060 16.768 1.00 0.00 strl ATOM 89 C5 CYT 3 10.471-32. 127 16.288 1.00 0.00 strl ATOM 90 H5 CYT 3 11.526-32. 344 16.121 1.00 0.00 strl ATOM 91 C2'CYT 3 6.570-33. 593 14.679 1.00 0.00 strl ATOM 92 H2"CYT 3 6.644-32. 538 14. 386 1.00 0.00 strl ATOM 93 02'CYT 3 5.212-34. 048 14.625 1.00 0.00 strl ATOM 94 H2'CYT 3 4.937-34. 235 15.525 1.00 0.00 strl ATOM 95 C3'CYT 3 7.484-34. 467 13.829 1.00 0.00 strl ATOM 96 H3'CYT 3 8.439-33. 992 13.623 1.00 0.00 strl ATOM 97 03'CYT 3 6.769-34. 821 12.649 1.00 0.00 strl ATOM 98 P GUA 4 7.066-34. 085 11.249 1.00 0.00 strl ATOM 99 01P GUA 4 6.219-34. 701 10.203 1.00 0.00 strl ATOM 100 02P GUA 4 8.531-33. 993 11. 066 1.00 0.00 strl ATOM 101 05'GUA 4 6.498-32. 624 11.572 1.00 0.00 strl ATOM 102 C5'GUA 4 5.097-32. 402 11.618 1.00 0.00 strl ATOM 103 H5'GUA 4 4.666-33. 043 12.375 1.00 0.00 strl ATOM 104 H5''GUA 4 4.669-32. 646 10.634 1.00 0.00 strl ATOM 105 C4'GUA 4 4.755-30. 976 12.000 1.00 0.00 strl ATOM 106 H4'GUA 4 3.681-30. 820 11. 964 1. 00 0.00 strl ATOM 107 04'GUA 4 5.233-30. 693 13.321 1.00 0.00 strl ATOM 108 Cl'GUA 4 5.667-29. 322 13.391 1.00 0.00 strl ATOM 109 H1'GUA 4 5.095-28. 810 14. 156 1.00 0. 00 strl ATOM 110 N9 GUA 4 7.108-29. 184 13. 684 1.00 0.00 strl ATOM 111 C4 GUA 4 7.731-28. 036 14.119 1.00 0.00 strl ATOM 112 N3 GUA 4 7.116-26. 865 14.403 1.00 0.00 strl ATOM 113 C2 GUA 4 7.978-25. 925 14.799 1.00 0.00 strl ATOM 114 N2 GUA 4 7.538-24. 706 15.112 1.00 0.00 strl ATOM 115 HN'GUA 4 6.552-24. 493 15.051 1.00 0.00 strl ATOM 116 HN''GUA 4 8. 190-23.994 15.409 1.00 0.00 strl ATOM 117 Nl GUA 4 9.338-26. 129 14.905 1.00 0.00 strl ATOM 118 Hl GUA 4 9.921-25. 363 15.206 1.00 0.00 strl ATOM 119 C6 GUA 4 9.993-27. 321 14. 621 1.00 0.00 strl ATOM 120 06 GUA 4 11.213-27. 401 14.754 1.00 0.00 strl ATOM 121 C5 GUA 4 9.083-28. 328 14.197 1.00 0.00 strl ATOM 122 N7 GUA 4 9.322-29. 652 13.815 1.00 0.00 strl ATOM 123 C8 GUA 4 8.129-30. 065 13.535 1.00 0.00 strl ATOM 124 H8 GUA 4 7. 958-31. 071 13.160 1.00 0.00 strl ATOM 125 C2'GUA 4 5.368-28. 722 12.025 1.00 0.00 strl ATOM 126 H2"GUA 4 6.138-27. 995 11.756 1.00 0.00 strl ATOM 127 02'GUA 4 4.061-28. 137 11.978 1.00 0.00 strl ATOM 128 H2'GUA 4 3.932-27. 662 12.802 1.00 0.00 strl ATOM 129 C3'GUA 4 5.465-29. 950 11.141 1.00 0.00 strl ATOM 130 H3'GUA 4 6.497-30. 229 10.927 1. 00 0.00 strl ATOM 131 031 GUA 4 4.691-29. 726 9.959 1.00 0.00 strl ATOM 132 P CYT 5 5.414-29. 519 8. 536 1.00 0.00 strl ATOM 133 01P CYT 5 6.715-30. 223 8.571 1.00 0.00 strl ATOM 134 02P CYT 5 4.436-29. 829 7.470 1.00 0.00 strl ATOM 135 05'CYT 5 5.699-27. 934 8.514 1.00 0.00 strl ATOM 136 C5'CYT 5 4. 726-27. 015 9.019 1.00 0.00 strl ATOM 137 H5'CYT 5 4.160-27. 498 9.815 1.00 0.00 strl ATOM 138 H5"CYT 5 4. 044-26. 742 8.214 1.00 0.00 strl ATOM 139 C4'CYT 5 5.381-25. 749 9.569 1.00 0. 00 strl ATOM 140 H4'CYT 5 4.620-24. 988 9.734 1.00 0.00 strl ATOM 141 04'CYT 5 6.062-26. 010 10.802 1.00 0.00 strl ATOM 142 C1'CYT 5 7.358-25. 385 10.795 1. 00 0.00 strl ATOM 143 H1'CYT 5 7.468-24. 769 11.690 1.00 0.00 strl ATOM 144 N1 CYT 5 8.435-26. 398 10.741 1.00 0.00 strl ATOM 145 C6 CYT 5 8.218-27. 613 10.161 1.00 0.00 strl ATOM 146 H6 CYT 5 7.244-27. 837 9.727 1.00 0.00 strl ATOM 147 C2 CYT 5 9.668-26. 069 11.291 1.00 0.00 strl ATOM 148 02 CYT 5 9.839-24. 963 11.800 1.00 0.00 strl ATOM 149 N3 CYT 5 10.665-26. 994 11.242 1.00 0.00 strl ATOM 150 C4 CYT 5 10.465-28. 191 10.676 1.00 0.00 strl ATOM 151 N4 CYT 5 11.461-29. 076 10.647 1.00 0.00 strl ATOM 152 HN'CYT 5 12.358-28. 840 11.047 1.00 0.00 strl ATOM 153 HN''CYT 5 11.319-29. 982 10.225 1.00 0.00 strl ATOM 154 C5 CYT 5 9.197-28. 533 10.107 1.00 0.00 strl ATOM 155 H5 CYT 5 9.031-29. 503 9.645 1.00 0.00 strl ATOM 156 C2'CYT 5 7. 400-24.499 9.557 1.00 0.00 strl ATOM 157 H2''CYT 5 8.406-24. 499 9.135 1. 00 0.00 strl ATOM 158 02'CYT 5 6.961-23. 166 9.846 1.00 0.00 strl ATOM 159 H2'CYT 5 7.509-22. 834 10.561 1.00 0.00 strl ATOM 160 C3'CYT 5 6.444-25. 211 8. 620 1.00 0.00 strl ATOM 161 H3'CYT 5 6.941-26. 004 8.059 1.00 0.00 strl ATOM 162 03'CYT 5 5.840-24. 236 7.765 1.00 0.00 strl ATOM 163 P URI 6 6.245-24. 159 6.208 1.00 0.00 strl ATOM 164 01P URI 6 7.126-25. 308 5.901 1.00 0.00 strl ATOM 165 02P URI 6 5.011-23. 944 5.419 1.00 0.00 strl ATOM 166 05'URI 6 7.128-22. 814 6.138 1.00 0.00 strl ATOM 167 C5'URI 6 6.529-21. 568 5.768 1.00 0.00 strl ATOM 168 H5'URI 6 5.465-21. 603 6.005 1.00 0.00 strl ATOM 169 H5"URI 6 6.647-21. 421 4.694 1.00 0.00 strl ATOM 170 C4'URI 6 7.166-20. 393 6.518 1.00 0.00 strl ATOM 171 H4'URI 6 6.455-19. 570 6.580 1.00 0.00 strl ATOM 172 04'URI 6 7.562-20. 772 7.838 1.00 0.00 strl ATOM 173 C1'URI 6 8.805-20. 134 8.181 1.00 0.00 strl ATOM 174 H1'URI 6 8.657-19. 502 9.055 1.00 0.00 strl ATOM 175 N1 URI 6 9.858-21. 130 8.465 1.00 0. 00 strl ATOM 176 C6 URI 6 9. 702-22. 443 8.112 1.00 0.00 strl ATOM 177 H6 URI 6 8.782-22. 760 7. 622 1.00 0.00 strl ATOM 178 C2 URI 6 11.008-20. 682 9.090 1.00 0.00 strl ATOM 179 02 URI 6 11. 159-19.506 9.412 1.00 0.00 strl ATOM 180 N3 URI 6 11. 979-21. 635 9.332 1.00 0.00 strl ATOM 181 H3 URI 6 12.824-21. 320 9.788 1.00 0.00 strl ATOM 182 C4 URI 6 11.904-22. 979 9.009 1.00 0.00 strl ATOM 183 04 URI 6 12.836-23. 738 9.267 1.00 0.00 strl ATOM 184 C5 URI 6 10.669-23. 360 8.361 1. 00 0.00 strl ATOM 185 H5 URI 6 10.512-24. 399 8.072 1.00 0.00 strl ATOM 186 C2'URI 6 9.196-19. 263 6.992 1.00 0.00 strl ATOM 187 H2''URI 6 10.271-19. 330 6. 823 1.00 0.00 strl ATOM 188 02'URI 6 8.792-17. 902 7.182 1. 00 0. 00 strl ATOM 189 H2'URI 6 8.431-17. 833 8.069 1. 00 0. 00 strl ATOM 190 C3'URI 6 8.443-19. 912 5.845 1. 00 0.00 strl ATOM 191 H3'URI 6 9.007-20. 731 5.397 1.00 0.00 strl ATOM 192 03'URI 6 8.104-18. 897 4.895 1.00 0. 00 strl ATOM 193 P CYT 7 8. 874-18. 811 3.483 1. 00 0.00 strl ATOM 194 O1P CYT 7 8.010-18. 080 2.529 1.00 0. 00 strl ATOM 195 02P CYT 7 9.370-20. 163 3.142 1.00 0.-00 strl ATOM 196 05'CYT 7 10.143-17. 880 3.828 1.00 0.00 strl ATOM 197 C5'CYT 7 9.985-16. 469 4.014 1.00 0.00 strl ATOM 198 H5'CYT 7 8.958-16. 264 4.319 1.00 0.00 strl ATOM 199 H5''CYT 7 10. 181-15. 961 3.069 1.00 0.00 strl ATOM 200 C4'CYT 7 10. 937-15. 934 5.088 1.00 0.00 strl ATOM 201 H4'CYT 7 10. 534-15. 013 5.508 1.00 0.00 strl ATOM 202 04'CYT 7 11.119-16. 888 6.139 1.00 0.00 strl ATOM 203 C1'CYT 7 12.505-16. 953 6.517 1.00 0.00 strl ATOM 204 Hl'CYT 7 12.597-16. 774 7.588 1.00 0.00 strl ATOM 205 N1 CYT 7 13.088-18. 269 6.184 1.00 0.00 strl ATOM 206 C6 CYT 7 12.449-19. 127 5.337 1.00 0.00 strl ATOM 207 H6 CYT 7 11.486-18. 847 4.910 1.00 0.00 strl ATOM 208 C2 CYT 7 14.313-18. 588 6.751 1.00 0.00 strl ATOM 209 02 CYT 7 14.862-17. 796 7.514 1.00 0.00 strl ATOM 210 N3 CYT 7 14.876-19. 788 6.440 1.00 0.00 strl ATOM 211 C4 CYT 7 14.263-20. 641 5.609 1.00 0. 00 strl ATOM 212 N4 CYT 7 14.843-21. 808 5.327 1.00 0.00 strl ATOM 213 HN'CYT 7 15.736-22. 041 5.737 1.00 0.00 strl ATOM 214 HN''CYT 7 14.388-22. 460 4.704 1.00 0.00 strl ATOM 215 C5 CYT 7 12.998-20. 317 5.024 1.00 0.00 strl ATOM 216 H5 CYT 7 12. 496-21. 009 4.348 1.00 0.00 strl ATOM 217 C2'CYT 7 13.217-15. 843 5.754 1.00 0.00 strl ATOM 218 H2"CYT 7 14.212-16. 178 5.453 1.00 0.00 strl ATOM 219 02'CYT 7 13.291-14. 639 6.525 1.00 0.00 strl ATOM 220 H2'CYT 7 14.019-14. 120 6.174 1. 00 0.00 strl ATOM 221 C3'CYT 7 12.333-15. 670 4.534 1.00 0.00 strl ATOM 222 H3'CYT 7 12.600-16. 364 3.735 1.00 0.00 strl ATOM 223 03'CYT 7 12.406-14. 304 4.116 1.00 0.00 strl ATOM 224 P URI 8 13.291-13. 887 2.837 1.00 0.00 strl ATOM 225 01P URI 8 13.333-15. 037 1.907 1.00 0.00 strl ATOM 226 02P URI 8 12.819-12. 568 2.358 1.00 0.00 strl ATOM 227 05'URI 8 14.760-13. 696 3.468 1.00 0.00 strl ATOM 228 C5'URI 8 15.229-12. 396 3.835 1.00 0.00 strl ATOM 229 H5'URI 8 14. 450-11. 888 4.404 1.00 0.00 strl ATOM 230 H5''URI 8 15.435-11. 823 2.929 1.00 0.00 strl ATOM 231 C4'URI 8 16.500-12. 471 4.688 1.00 0.00 strl ATOM 232 H4'URI 8 16.596-11. 561 5.279 1.00 0.00 strl ATOM 233 04'URI 8 16.475-13. 604 5.570 1.00 0.00 strl ATOM 234 C1'URI 8 17.715-14. 327 5.463 1.00 0.00 strl ATOM 235 H1'URI 8 18.078-14. 586 6.457 1.00 0.00 strl ATOM 236 N1 URI 8 17.549-15. 550 4.655 1.00 0.00 strl ATOM 237 C6 URI 8 16.389-15. 785 3.976 1.00 0.00 strl ATOM 238 H6 URI 8 15.610-15. 028 3.986 1.00 0.00 strl ATOM 239 C2 URI 8 18.598-16. 447 4.625 1.00 0.00 strl ATOM 240 02 URI 8 19.650-16. 244 5.227 1.00 0.00 strl ATOM 241 N3 URI 8 18.395-17. 592 3.874 1.00 0.00 strl ATOM 242 H3 URI 8 19.166-18. 231 3.802 1.00 0.00 strl ATOM 243 C4 URI 8 17.250-17. 917 3.171 1.00 0.00 strl ATOM 244 04 URI 8 17.170-18. 983 2.560 1.00 0.00 strl ATOM 245 C5 URI 8 16.209-16. 918 3.254 1.00 0.00 strl ATOM 246 H5 URI 8 15.267-17. 078 2.729 1.00 0.00 strl ATOM 247 C2'URI 8 18.682-13. 372 4.793 1.00 0.00 strl ATOM 248 H2''URI 8 19.443-13. 930 4.247 1.00 0.00 strl ATOM 249 02'URI 8 19.272-12. 467 5.734 1.00 0.00 strl ATOM 250 H2'URI 8 18.730-11. 675 5.747 1.00 0.00 strl ATOM 251 C3'URI 8 17.752-12. 658 3.835 1.00 0.00 strl ATOM 252 H3'URI 8 17.556-13. 251 2.940 1.00 0.00 strl ATOM 253 03'URI 8 18.303-11. 376 3.531 1.00 0. 00 strl ATOM 254 P ADE 9 19.000-11. 116 2.103 1.00 0.00 strl ATOM 255 01P ADE 9 18.246-10. 049 1.406 1.00 0.00 strl ATOM 256 02P ADE 9 20.457-10. 968 2.319 1.00 0.00 strl ATOM 257 05'ADE 9 18.743-12. 508 1.324 1.00 0.00 strl ATOM 258 C5'ADE 9 17.851-12. 546 0.207 1.00 0.00 strl ATOM 259 H5'ADE 9 17.976-11. 624-0. 364 1.00 0.00 strl ATOM 260 H5"ADE 9 16.826-12. 586 0.576 1.00 0.00 strl ATOM 261 C4'ADE 9 18.118-13. 748-0.725 1.00 0.00 strl ATOM 262 H4'ADE 9 17.876-13. 464-1.743 1.00 0.00 strl ATOM 263 04'ADE 9 19.489-14. 176-0.662 1.00 0.00 strl ATOM 264 C1'ADE 9 19.582-15. 417 0.075 1.00 0.00 strl ATOM 265 H1'ADE 9 19.814-16. 239-0.599 1.00 0.00 strl ATOM 266 N9 ADE 9 20. 608-15.336 1. 117 1.00 0.00 strl ATOM 267 C4 ADE 9 21. 598-16. 251 1. 387 1.00 0. 00 strl ATOM 268 N3 ADE 9 21.824-17. 405 0.730 1.00 0.00 strl ATOM 269 C2 ADE 9 22.861-18. 059 1.245 1.00 0.00 strl ATOM 270 H2 ADE 9 23.117-19. 008 0.775 1.00 0.00 strl ATOM 271 N1 ADE 9 23. 622-17. 681 2. 274 1.00 0.00 strl ATOM 272 C6 ADE 9 23.377-16. 524 2.914 1.00 0. 00 strl ATOM 273 N6 ADE 9 24.149-16. 164 3. 940 1.00 0.00 strl ATOM 274 HN'ADE 9 24.911-16. 760 4.231 1.00 0.00 strl ATOM 275 HN''ADE 9 23.972-15. 297 4.425 1.00 0.00 strl ATOM 276 C5 ADE 9 22.305-15. 751 2.456 1.00 0. 00 strl ATOM 277 N7 ADE 9 21.771-14. 525 2.870 1.00 0. 00 strl ATOM 278 C8 ADE 9 20.797-14. 376 2.035 1. 00 0. 00 strl ATOM 279 H8 ADE 9 20.135-13. 518 2. 074 1.00 0.00 strl ATOM 280 C2'ADE 9 18.213-15. 640 0.691 1. 00 0.00 strl ATOM 281 H2''ADE 9 18.144-15. 116 1.648 1.00 0.00 strl ATOM 282 02'ADE 9 17.923-17. 033 0.833 1.00 0.00 strl ATOM 283 H2'ADE 9 18. 618-17. 415 1.375 1.00 0.00 strl ATOM 284 C3'ADE 9 17.315-14. 989-0.336 1.00 0. 00 strl ATOM 285 H3'ADE 9 16.332-14. 751 0.063 1.00 0.00 strl ATOM 286 03'ADE 9 17.255-15. 879-1.461 1.00 0.00 strl ATOM 287 P URI 10 15.992-15. 893-2.462 1.00 0.00 strl ATOM 288 O1P URI 10 15.466-17. 275-2.521 1.00 0.00 strl ATOM 289 02P URI 10 15.094-14. 778-2.088 1.00 0.00 strl ATOM 290 05'URI 10 16.659-15. 546-3.890 1.00 0.00 strl ATOM 291 C5'URI 10 18.081-15. 534-4.049 1.00 0.00 strl ATOM 292 H5'URI 10 18.468-16. 537-3.863 1.00 0.00 strl ATOM 293 H5''URI 10 18.496-14. 872-3.308 1.00 0.00 strl ATOM 294 C4'URI 10 18.491-15. 075-5.471 1.00 0.00 strl ATOM 295 H4'URI 10 19.101-15. 849-5.940 1. 00 0.00 strl ATOM 296 04'URI 10 17.334-14. 857-6.278 1.00 0.00 strl ATOM 297 C1'URI 10 17.104-13. 455-6.492 1.00 0.00 strl ATOM 298 Hl'URI 10 17.162-13. 247-7.562 1.00 0.00 strl ATOM 299 N1 URI 10 15.766-13. 058-5.968 1.00 0. 00 strl ATOM 300 C6 URI 10 15. 448-13. 260-4. 651 1.00 0.00 strl ATOM 301 H6 URI 10 16.191-13. 695-3.987 1.00 0.00 strl ATOM 302 C2 URI 10 14.852-12. 492-6.848 1.00 0.00 strl ATOM 303 02 URI 10 15.117-12. 302-8.033 1.00 0.00 strl ATOM 304 N3 URI 10 13.621-12. 153-6.314 1.00 0.00 strl ATOM 305 H3 URI 10 12.948-11. 741-6.943 1.00 0.00 strl ATOM 306 C4 URI 10 13. 226-12. 326-4.998 1.00 0.00 strl ATOM 307 04 URI 10 12.102-11. 987-4. 632 1.00 0.00 strl ATOM 308 C5 URI 10 14.237-12. 920-4.153 1.00 0.00 strl ATOM 309 H5 URI 10 14.022-13. 099-3.099 1.00 0.00 strl ATOM 310 C2'URI 10 18.223-12. 690-5.778 1.00 0.00 strl ATOM 311 H2"URI 10 17.854-12. 268-4.840 1.00 0.00 strl ATOM 312 02'URI 10 18.757-11. 657-6.614 1.00 0.00 strl ATOM 313 H2'URI 10 19.059-12. 074-7.425 1.00 0.00 strl ATOM 314 C3'URI 10 19. 271-13. 753-5.486 1.00 0.00 strl ATOM 315 H3'URI 10 19.784-13. 561-4.546 1.00 0.00 strl ATOM 316 03'URI 10 20.188-13. 789-6.584 1.00 0.00 strl ATOM 317 P GUA 11 21.771-13. 608-6.332 1.00 0.00 strl ATOM 318 01P GUA 11 22.435-14. 899-6.618 1.00 0.00 strl ATOM 319 02P GUA 11 22.213-12. 381-7.031 1.00 0.00 strl ATOM 320 05'GUA 11 21.849-13. 340-4. 743 1.00 0. 00 strl ATOM 321 C5'GUA 11 21.940-12. 000-4.234 1.00 0.00 strl ATOM 322 H5'GUA 11 20.951-11. 565-4.190 1.00 0.00 strl ATOM 323 H5"GUA 11 22.571-11. 413-4.918 1.00 0.00 strl ATOM 324 C4'GUA 11 22.512-11. 943-2.821 1.00 0.00 strl ATOM 325'H4'GUA 11 22.554-10. 907-2.490 1.00 0.00 strl ATOM 326 04'GUA 11 21.717-12. 700-1.895 1.00 0.00 strl ATOM 327 C1'GUA 11 22.561-13. 590-1.143 1.00 0.00 strl ATOM 328 Hl'GUA 11 22.268-13. 569-0.093 1.00 0.00 strl ATOM 329 N9 GUA 11 22. 445-14. 962-1.662 1.00 0.00 strl ATOM 330 C4 GUA 11 23.280-16. 032-1.421 1.00 0.00 strl ATOM 331 N3 GUA 11 24.386-16. 025-0.641 1.00 0.00 strl ATOM 332 C2 GUA 11 24.985-17. 222-0.607 1.00 0.00 strl ATOM 333 N2 GUA 11 26.089-17. 397 0.119 1.00 0.00 strl ATOM 334 HN'GUA 11 26.540-18. 300 0.143 1.00 0.00 strl ATOM 335 HN"GUA 11 26. 475-16.626 0. 645 1.00 0.00 strl ATOM 336 N1 GUA 11 24.522-18. 330-1.292 1.00 0.00 strl ATOM 337 Hl GUA 11 25.023-19. 201-1.210 1.00 0.00 strl ATOM 338 C6 GUA 11 23.393-18. 356-2.097 1.00 0.00 strl ATOM 339 06 GUA 11 23. 074-19. 385-2. 678 1.00 0.00 strl ATOM 340 C5 GUA 11 22.753-17. 095-2. 137 1.00 0.00 strl ATOM 341 N7 GUA 11 21.601-16. 704-2.821 1.00 0.00 strl ATOM 342 C8 GUA 11 21. 509-15. 466-2. 483 1.00 0.00 strl ATOM 343 H8 GUA 11 20.705-14. 842-2. 841 1.00 0.00 strl ATOM 344 C2'GUA 11 23.972-13. 046-1. 319 1.00 0.00 strl ATOM 345 H2''GUA 11 24.710-13. 847-1.224 1.00 0.00 strl ATOM 346 02'GUA 11 24.244-11. 977-0.405 1.00 0.00 strl ATOM 347 H2'GUA 11 24.470-12. 374 0.440 1.00 0.00 strl ATOM 348 C3'GUA 11 23.908-12. 554-2.751 1.00 0.00 strl ATOM 349 H3'GUA 11 24.040-13. 369-3.466 1.00 0.00 strl ATOM 350 03'GUA 11 24.871-11. 512-2.926 1.00 0.00 strl ATOM 351 P CYT 12 25.887-11. 550-4.176 1.00 0. 00 strl ATOM 352 01P CYT 12 26.553-10. 232-4.272 1.00 0.00 strl ATOM 353 02P CYT 12 25.166-12. 101-5.345 1.00 0.00 strl ATOM 354 05'CYT 12 26.979-12. 634-3.701 1.00 0.00 strl ATOM 355 C5'CYT 12 27.618-12. 492-2.432 1.00 0.00 strl ATOM 356 H5'CYT 12 26. 861-12. 280-1.676 1.00 0.00 strl ATOM 357 H5''CYT 12 28.315-11. 656-2.479 1.00 0.00 strl ATOM 358 C4'CYT 12 28.379-13. 753-2.030 1.00 0.00 strl ATOM 359 H4'CYT 12 29.154-13. 499-1.308 1.00 0.00 strl ATOM 360 04'CYT 12 27.512-14. 745-1.462 1.00 0.00 strl ATOM 361 C1'CYT 12 27. 927-16. 050-1.915 1.00 0.00 strl ATOM 362 Hl'CYT 12 28.121-16. 694-1.061 1.00 0. 00 strl ATOM 363 N1 CYT 12 26.912-16. 673-2.792 1.00 0.00 strl ATOM 364 C6 CYT 12 25.877-15. 943-3.305 1.00 0.00 strl ATOM 365 H6 CYT 12 25.779-14. 889-3.051 1.00 0.00 strl ATOM 366 C2 CYT 12 27.066-18. 020-3.092 1.00 0.00 strl ATOM 367 02 CYT 12 28.007-18. 654-2.617 1.00 0.00 strl ATOM 368 N3 CYT 12 26.158-18. 606-3.919 1.00 0.00 strl ATOM 369 C4 CYT 12 25.139-17. 903-4.431 1.00 0.00 strl ATOM 370 N4 CYT 12 24. 269-18.508-5. 240 1.00 0.00 strl ATOM 371 HN'CYT 12 23.498-17. 988-5.632 1.00 0.00 strl ATOM 372 HN''CYT 12 24.383-19. 487-5.463 1.00 0.00 strl ATOM 373 C5 CYT 12 24. 974-16. 516-4.124 1.00 0.00 strl ATOM 374 H5 CYT 12 24.145-15. 942-4.540 1.00 0.00 strl ATOM 375 C2'CYT 12 29.220-15. 831-2.674 1.00 0.00 strl ATOM 376 H2''CYT 12 29.306-16. 554-3.474 1.00 0.00 strl ATOM 377 02'CYT 12 30.358-15. 882-1.805 1.00 0.00 strl ATOM 378 H2'CYT 12 30.595-16. 806-1.699 1.00 0.00 strl ATOM 379 C3'CYT 12 29.005-14. 443-3.228 1.00 0.00 strl ATOM 380 H3'CYT 12 28.346-14. 443-4.098 1.00 0.00 strl ATOM 381 03'CYT 12 30.283-13. 868-3.501 1.00 0.00 strl ATOM 382 P URI 13 30.855-13. 822-5.009 1.00 0.00 strl ATOM 383 01P URI 13 29.754-13. 408-5.908 1.00 0.00 strl ATOM 384 02P URI 13 32.124-13. 060-4.999 1.00 0.00 strl ATOM 385 05'URI 13 31.199-15. 369-5.313 1.00 0.00 strl ATOM 386 C5'URI 13 32.377-15. 957-4.763 1.00 0.00 strl ATOM 387 H5'URI 13 32.300-15. 931-3. 674 1. 00 0. 00 strl ATOM 388 H5''URI 13 33.242-15. 370-5.071 1.00 0.00 strl ATOM 389 C4'URI 13 32.579-17. 409-5.205 1.00 0. 00 strl ATOM 390 H4'URI 13 33.551-17. 760-4.865 1. 00 0.00 strl ATOM 391 04'URI 13 31.565-18. 274-4.683 1.00 0.00 strl ATOM 392 C1'URI 13 31.297-19. 324-5.640 1.00 0.00 strl ATOM 393 HI'URI 13 31.490-20. 294-5.186 1.00 0.00 strl ATOM 394 N1 URI 13 29.901-19. 268-6.130 1.00 0. 00 strl ATOM 395 C6 URI 13 29.141-18. 146-5.958 1.00 0.00 strl ATOM 396 H6 URI 13 29.587-17. 271-5.501 1.00 0. 00 strl ATOM 397 C2 URI 13 29.397-20. 390-6.762 1.00 0.00 strl ATOM 398 02 URI 13 30.069-21. 405-6.927 1.00 0.00 strl ATOM 399 N3 URI 13 28.087-20. 304-7.200 1.00 0.00 strl ATOM 400 H3 URI 13 27.708-21. 113-7.668 1.00 0.00 strl ATOM 401 C4 URI 13 27.249-19. 210-7.060 1.00 0.00 strl ATOM 402 04 URI 13 26.099-19. 242-7.491 1.00 0.00 strl ATOM 403 C5 URI 13 27.859-18. 084-6.389 1.00 0.00 strl ATOM 404 H5 URI 13 27.275-17. 179-6.211 1.00 0.00 strl ATOM 405 C2'URI 13 32.277-19. 099-6.781 1.00 0.00 strl ATOM 406 H2''URI 13 31. 827-19. 394-7.724 1.00 0.00 strl ATOM 407 02'URI 13 33.508-19. 796-6.557 1.00 0.00 strl ATOM 408 H2'URI 13 33.879-19. 465-5.735 1.00 0.00 strl ATOM 409 C3'URI 13 32.471-17. 594-6.709 1.00 0.00 strl ATOM 410 H3'URI 13 31.633-17. 044-7.140 1.00 0.00 strl ATOM 411 03'URI 13 33.726-17. 275-7.318 1.00 0.00 strl ATOM 412 P CYT 14 33.799-16. 671-8.815 1. OO 0.00 strl ATOM 413 01P CYT 14 35.211-16. 341-9.115 1.00 0. 00 strl ATOM 414 02P CYT 14 32.752-15. 633-8.949 1.00 0.00 strl ATOM 415 05'CYT 14 33.373-17. 939-9.710 1.00 0.00 strl ATOM 416 C5'CYT 14 34.302-18. 994-9.942 1.00 0.00 strl ATOM 417 H5'CYT 14 34.634-19. 391-8.982 1. 00 0.00 strl ATOM 418 H5"CYT 14 35.164-18. 596-10.477 1.00 0.00 strl ATOM 419 C4'CYT 14 33.691-20. 128-10.762 1.00 0.00 strl ATOM 420 H4'CYT 14 34.444-20. 883-10.977 1.00 0.00 strl ATOM 421 04'CYT 14 32.612-20. 730-10. 045 1.00 0.00 strl ATOM 422 Cl'CYT 14 31.626-21. 220-10.974 1.00 0.00 strl ATOM 423 HI'CYT 14 31.565-22. 303-10.886 1.00 0.00 strl ATOM 424 N1 CYT 14 30.288-20. 625-10.749 1.00 0.00 strl ATOM 425 C6 CYT 14 30.132-19. 462-10.053 1.00 0.00 strl ATOM 426 H6 CYT 14 30.997-18. 964-9.637 1.00 0.00 strl ATOM 427 C2 CYT 14 29.202-21. 270-11.323 1.00 0. 00 strl ATOM 428 02 CYT 14 29.366-22. 316-11.947 1.00 0.00 strl ATOM 429 N3 CYT 14 27.967-20. 717-11.176 1.00 0. 00 strl ATOM 430 C4 CYT 14 27.801-19. 578-10.494 1.00 0.00 strl ATOM 431 N4 CYT 14 26.578-19. 064-10.366 1. 00 0.00 strl ATOM 432 HN'CYT 14 25.787-19. 534-10.783 1.00 0.00 strl ATOM 433 HN''CYT 14 26.441-18. 207-9.849 1.00 0.00 strl ATOM 434 C5 CYT 14 28.916-18. 908-9.902 1.00 0.00 strl ATOM 435 H5 CYT 14 28.789-17. 978-9.352 1.00 0.00 strl ATOM 436 C2'CYT 14 32.132-20. 835-12.365 1.00 0.00 strl ATOM 437 H2''CYT 14 31.298-20. 513-12.993 1.00 0.00 strl ATOM 438 02'CYT 14 32.856-21. 908-12.977 1.00 0.00 strl ATOM 439 H2'CYT 14 32.514-22. 728-12. 613 1.00 0.00 strl ATOM 440 C3'CYT 14 33.039-19. 658-12. 049 1.00 0.00 strl ATOM 441 H3'CYT 14 32. 484.-18. 729-11.926 1.00 0.00 strl ATOM 442 03'CYT 14 34.036-19. 571-13.070 1.00 0.00 strl ATOM 443 P URI 15 33.809-18. 613-14.345 1.00 0.00 strl ATOM 444 01P URI 15 35.009-18. 696-15.206 1.00 0.00 strl ATOM 445 02P URI 15 33.339-17. 297-13.858 1.00 0.00 strl ATOM 446 05'URI 15 32.588-19. 331-15.113 1.00 0.00 strl ATOM 447 C5'URI 15 32.843-20. 394-16.034 1. 00 0.00 strl ATOM 448 H5'URI 15 33. 277-21. 233-15.491 1.00 0.00 strl ATOM 449 H5''URI 15 33.555-20. 048-16.782 1.00 0.00 strl ATOM 450 C4'URI 15 31. 567-20. 862-16. 735 1.00 0.00 strl ATOM 451 H4'URI 15 31.801-21. 660-17.440 1.00 0.00 strl ATOM 452 04'URI 15 30.589-21. 325-15.807 1.00 0.00 strl ATOM 453 C1'URI 15 29.282-20. 906-16.233 1.00 0. 00' strl ATOM 454 Hl'URI 15 28.648-21. 783-16.350 1.00 0.00 strl ATOM 455 N1 URI 15 28.689-19. 966-15.247 1.00 0.00 strl ATOM 456 C6 URI 15 29.484-19. 098-14.545 1.00 0.00 strl ATOM 457 H6 URI 15 30.562-19. 107-14.710 1.00 0.00 strl ATOM 458 C2 URI 15 27.314-19. 991-15.062 1.00 0.00 strl ATOM 459 02 URI 15 26.586-20. 762-15.683 1.00 0.00 strl ATOM 460 N3 URI 15 26.808-19. 096-14.136 1. 00 0.00 strl ATOM 461 H3 URI 15 25.810-19. 107-13.986 1.00 0.00 strl ATOM 462 C4 URI 15 27.540-18. 189-13.391 1.00 0.00 strl ATOM 463 04 URI 15 26.982-17. 437-12.595 1.00 0.00 strl ATOM 464 C5 URI 15 28.961-18. 229-13.646 1.00 0.00 strl ATOM 465 H5 URI 15 29.622-17. 547-13.109 1.00 0.00 strl ATOM 466 C2'URI 15 29.470-20. 230-17.592 1. 00 0.00 strl ATOM 467 H2"URI 15 28.785-19. 383-17.689 1.00 0.00 strl ATOM 468 02'URI 15 29.300-21. 158-18.670 1.00 0.00 strl ATOM 469 H2'URI 15 29.462-22. 037-18.318 1. 0-0 0.00 strl ATOM 470 C3'URI 15 30.902-19. 743-17.496 1.00 0.00 strl ATOM 471 H3'URI 15 30.973-18. 783-16.998 1.00 0.00 strl ATOM 472 03'URI 15 31.489-19. 728-18.786 1.00 0.00 strl ATOM 473 P URI 16 31.306-18. 469-19.746 1. 00 0.00 strl ATOM 474 01P URI 16 30. 344-17. 535-19.120 1.00 0.00 strl ATOM 475 02P URI 16 32.645-17. 995-20.162 1. 00 0.00 strl ATOM 476 05'URI 16 30.602-19. 161-20.998 1.00 0.00 strl ATOM 477 C5'URI 16 29.219-18. 961-21. 244 1.00 0. 00 strl ATOM 478 H5'URI 16 28.946-17. 906-21. 269 1.00 0.00 strl ATOM 479 H5"URI 16 28.702-19. 424-20.399 1.00 0.00 strl ATOM 480 C4'URI 16 28.828-19. 626-22.579 1.00 0.00 strl ATOM 481 H4'URI 16 28.373-18. 892-23.242 1.00 0.00 strl ATOM 482 04'URI 16 30.029-20. 110-23.191 1.00 0.00 strl ATOM 483 C1'URI 16 29.997-21. 524-23.425 1.00 0.00 strl ATOM 484 H1'URI 16 30.071-21. 684-24.503 1.00 0.00 strl ATOM 485 N1 URI 16 31.123-22. 243-22.744 1.00 0.00 strl ATOM 486 C6 URI 16 31.595-21. 870-21.498 1.00 0.00 strl ATOM 487 H6 URI 16 31.150-21. 026-20.971 1.00 0.00 strl ATOM 488 C2 URI 16 31.679-23. 324-23.418 1. 00 0.00 strl ATOM 489 02 URI 16 31.278-23. 675-24.526 1.00 0.00 strl ATOM 490 N3 URI 16 32.709-23. 986-22.779 1.00 0.00 strl ATOM 491 H3 URI 16 33.117-24. 773-23.264 1.00 0.00 strl ATOM 492 C4 URI 16 33. 235-23. 677-21. 539 1.00 0.00 strl ATOM 493 04 URI 16 34.156-24. 339-21.067 1. 00 0.00 strl ATOM 494 C5 URI 16 32. 608-22. 544-20. 900 1.00 0.00 strl ATOM 495 H5 URI 16 32. 956-22. 226-19. 918 1.00 0.00 strl ATOM 496 C2'URI 16 28. 647-22. 055-22.958 1.00 0.00 strl ATOM 497 H2"URI 16 28.780-22. 803-22.169 1.00 0.00 strl ATOM 498 02'URI 16 27. 934-22. 636-24.056 1.00 0.00 strl ATOM 499 H2'URI 16 28.396-23. 441-24.302 1.00 0.00 strl ATOM 500 C3'URI 16 27. 893-20. 831-22.423 1.00 0.00 strl ATOM 501 H3'URI 16 27.543-20. 975-21.408 1.00 0.00 strl ATOM 502 03'URI 16 26. 829-20. 598-23. 368 1.00 0.00 strl ATOM 503 P CYT 17 25.760-19. 373-23.252 1.00 0.00 strl ATOM 504 01P CYT 17 26.501-18. 108-23.459 1.00 0.00 strl ATOM 505 02P CYT 17 24.612-19. 692-24.129 1.00 0.00 strl ATOM 506 05'CYT 17 25.236-19. 388-21.737 1.00 0.00 strl ATOM 507 C5'CYT 17 24.103-20. 177-21.405 1.00 0.00 strl ATOM 508 H5'CYT 17 24.455-21. 192-21.288 1.00 0.00 strl ATOM 509 H5''CYT 17 23.360-20. 131-22.220 1.00 0.00 strl ATOM 510 C4'CYT 17 23.434-19. 736-20.104 1.00 0.00 strl ATOM 511 H4'CYT 17 22.789-20. 533-19.756 1.00 0.00 strl ATOM 512 04'CYT 17 24.409-19. 450-19.096 1.00 0.00 strl ATOM 513 C1'CYT 17 24.145-18. 168-18.523 1. 00. 0.00 strl ATOM 514 H1'CYT 17 23.482-18. 289-17.665 1.00 0.00 strl ATOM 515 N1 CYT 17 25.405-17. 498-18.118 1.00 0. 00 strl ATOM 516 C6 CYT 17 26.485-17. 494-18.953 1.00 0.00 strl ATOM 517 H6 CYT 17 26.409-17. 963-19.936 1.00 0.00 strl ATOM 518 C2 CYT 17 25. 458-16. 891-16. 866 1.00 0.00 strl ATOM 519 02 CYT 17 24.471-16. 906-16.134 1.00 0.00 strl ATOM 520 N3 CYT 17 26.619-16. 292-16.486 1.00 0.00 strl ATOM 521 C4 CYT 17 27.686-16. 285-17.294 1.00 0.00 strl ATOM 522 N4 CYT 17 28.808-15. 690-16.891 1.00 0.00 strl ATOM 523 HN'CYT 17 29.619-15. 679-17.493 1.00 0.00 strl ATOM 524 HN"CYT 17 28.848-15. 251-15.982 1.00 0.00 strl ATOM 525 C5 CYT 17 27.637-16. 905-18. 582 1.00 0.00 strl ATOM 526 H5 CYT 17 28.506-16. 910-19.237 1.00 0.00 strl ATOM 527 C2'CYT 17 23.429-17. 386-19. 609 1. 00 0.00 strl ATOM 528 H2"CYT 17 24.152-16. 984-20.324 1.00 0.00 strl ATOM 529 02'CYT 17 22.613-16. 345-19.059 1.00 0.00 strl ATOM 530 H2'CYT 17 22. 200-16. 695-18. 266 1.00 0.00 strl ATOM 531 C3'CYT 17 22.589-18. 468-20. 266 1. 00 0.00 strl ATOM 532 H3'CYT 17 22.362-18. 236-21. 310 1.00 0.00 strl ATOM 533 03'CYT 17 21.403-18. 648-19.478 1.00 0.00 strl ATOM 534 P GUA 18 19.942-18. 421-20.112 1.00 0.00 strl ATOM 535 01P GUA 18 20.072-18. 443-21.587 1.00 0.00 strl ATOM 536 02P GUA 18 19.328-17. 251-19.447 1.00 0.00 strl ATOM 537 05'GUA 18 19.124-19. 742-19.661 1.00 0.00 strl ATOM 538 C5'GUA 18 19.638-20. 665-18.681 1.00 0.00 strl ATOM 539 H5'GUA 18 19.030-20. 615-17.788 1.00 0.00 strl ATOM 540 H5"GUA 18 20.674-20. 390-18.439 1.00 0.00 strl ATOM 541 C4'GUA 18 19.578-22. 107-19.174 1.00 0.00 strl ATOM 542 H4'GUA 18 18.573-22. 330-19.527 1.00 0.00 strl ATOM 543 04'GUA 18 20.507-22. 325-20.237 1.00 0.00 strl ATOM 544 C1'GUA 18 21.029-23. 662-20.165 1.00 0.00 strl ATOM 545 H1'GUA 18 20. 700-24. 223-21.040 1.00 0.00 strl ATOM 546 N9 GUA 18 22.505-23. 663-20.114 1.00 0.00 strl ATOM 547 C4 GUA 18 23.298-23. 038-19.177 1.00 0. 00 strl ATOM 548 N3 GUA 18 22.859-22. 307-18.126 1.00 0.00 strl ATOM 549 C2 GUA 18 23.866-21. 822-17.391 1. 00 0.00 strl ATOM 550 N2 GUA 18 23. 609-21. 076-16.316 1.00 0.00 strl ATOM 551 HN'GUA 18 24.370-20. 711-15.762 1.00 0.00 strl ATOM 552 HN''GUA 18 22.654-20. 876-16.057 1.00 0.00 strl ATOM 553 N1 GUA 18 25.199-22. 045-17.675 1.00 0.00 strl ATOM 554 H1 GUA 18 25.900-21. 638-17.072 1.00 0. 00 strl ATOM 555 C6 GUA 18 25. 674-22. 793-18.746 1.00 0.00 strl ATOM 556 06 GUA 18 26. 883-22. 933-18.912 1.00 0.00 strl ATOM 557 C5 GUA 18 24. 610-23. 311-19.533 1.00 0.00 strl ATOM 558 N7 GUA 18 24. 652-24. 103-20.685 1.00 0. 00 strl ATOM 559 C8 GUA 18 23. 397-24. 255-20. 946 1.00 0.00 strl ATOM 560 H8 GUA 18 23.065-24. 840-21.804 1.00 0.00 strl ATOM 561 C2'GUA 18 20.441-24. 300-18.909 1.00 0.00 strl ATOM 562 H2''GUA 18 21.217-24. 843-18.365 1.00 0.00 strl ATOM 563 02'GUA 18 19.348-25. 167-19.230 1.00 0.00 strl ATOM 564 H2'GUA 18 19.189-25. 089-20.173 1.00 0.00 strl ATOM 565 C3'GUA 18 19.975-23. 103-18.093 1.00 0.00 strl ATOM 566 H3'GUA 18 20.763-22. 717-17.449 1.00 0.00 strl ATOM 567 03'GUA 18 18.805-23. 492-17.352 1.00 0.00 strl ATOM 568 P GUA 19 18.710-23. 253-15.753 1.00 0.00 strl ATOM 569 O1P GUA 19 17.280-23. 136-15.390 1.00 0.00 strl ATOM 570 02P GUA 19 19.650-22. 169-15.393 1.00 0.00 strl ATOM 571 05'GUA 19 19.276-24. 640-15.129 1.00 0.00 strl ATOM 572 C5'GUA 19 19.534-25. 768-15.979 1.00 0.00 strl ATOM 573 H5'GUA 19 19.266-25. 533-16.993 1.00 0.00 strl ATOM 574 H5''GUA 19 18.913-26. 604-15.626 1.00 0.00 strl ATOM 575 C4'GUA 19 21.001-26. 193-15.986 1.00 0.00 strl ATOM 576 H4'GUA 19 21.116-27. 101-16.573 1.00 0.00 strl ATOM 577 04'GUA 19 21.846-25. 168-16.538 1.00 0.00 strl ATOM 578 C1'GUA 19 23.085-25. 113-15.794 1.00 0.00 strl ATOM 579 H1'GUA 19 23.934-25. 214-16.472 1.00 0.00 strl ATOM 580 N9 GUA 19 23.216-23. 861-15.024 1.00 0.00 strl ATOM 581 C4 GUA 19 24.373-23. 366-14.471 1.00 0.00 strl ATOM 582 N3 GUA 19 25.603-23. 918-14.583 1.00 0.00 strl ATOM 583 C2 GUA 19 26.533-23. 214-13.933 1.00 0.00 strl ATOM 584 N2 GUA 19 27.804-23. 615-13.945 1.00 0.00 strl ATOM 585 HN'GUA 19 28.506-23. 082-13.453 1.00 0. 00 strl ATOM 586 HN''GUA 19 28.065-24. 450-14.449 1.00 0.00 strl ATOM 587 N1 GUA 19 26.263-22. 058-13.228 1.00 0.00 strl ATOM 588 Bl GUA 19 27.020-21. 593-12.753 1.00 0.00 strl ATOM 589 C6 GUA 19 25.011-21. 471-13.100 1.00 0.00 strl ATOM 590 06 GUA 19 24.879-20. 434-12.453 1.00 0.00 strl ATOM 591 C5 GUA 19 24.016-22. 213-13.788 1.00 0.00 strl ATOM 592 N7 GUA 19 22.645-21. 976-13.909 1.00 0.00 strl ATOM 593 C8 GUA 19 22.269-22. 974-14.635 1.00 0.00 strl ATOM 594 H8 GUA 19 21.227-23. 107-14. 909 1.00 0. 00 strl ATOM 595 C2'GUA 19 23.045-26. 296-14.844 1.00 0.00 strl ATOM 596 H2"GUA 19 23. 574-26. 058-13.924 1.00 0.00 strl ATOM 597 02'GUA 19 23.570-27. 481-15.453 1. 00 0.00 strl ATOM 598 H2'GUA 19 24.292-27. 791-14.901 1.00 0.00 strl ATOM 599 C3'GUA 19 21.560-26. 410-14. 587 1.00 0.00 strl ATOM 600 H3'GUA 19 21.201-25. 668-13.873 1.00 0.00 strl ATOM 601 03'GUA 19 21.278-27. 752-14.183 1.00 0.00 strl ATOM 602 P ADE 20 21.155-28. 157-12.626 1.00 0.00 strl ATOM 603 OlP ADE 20 20. 366-27.112-11. 936 1.00 0.00 strl ATOM 604 02P ADE 20 20.732-29. 573-12.548 1.00 0.00 strl ATOM 605 05'ADE 20 22. 682-28. 056-12. 116 1.00 0. 00 strl ATOM 606 C5'ADE 20 23.615-29. 086-12. 449 1.00 0.00 strl ATOM 607 H5'ADE 20 23.720-29. 128-13.533 1. 00 0.00 strl ATOM 608 H5"ADE 20 23.227-30. 040-12.095 1.00 0. 00 strl ATOM 609 C4'ADE 20 24.994-28. 853-11.829 1.00 0.00 strl ATOM 610 H4'ADE 20 25.636-29. 709-12.028 1.00 0. 00 strl ATOM 611 04'ADE 20 25.617-27. 668-12.346 1. 00 0. 00 strl ATOM 612 C1'ADE 20 26.421-27. 060-11. 309 1.00 0.00 strl ATOM 613 H1'ADE 20 27. 465-27.038-11. 620 1.00 0.00 strl ATOM 614 N9 ADE 20 25.973-25. 693-10. 979 1.00 0. 00 strl ATOM 615 C4 ADE 20 26.688-24. 748-10.278 1.00 0.00 strl ATOM 616 N3 ADE 20 27.944-24. 883-9.808 1.00 0.00 strl ATOM 617 C2 ADE 20 28.342-23. 787-9.169 1.00 0.00 strl ATOM 618 H2 ADE 20 29.349-23. 810-8.748 1.00 0.00 strl ATOM 619 N1 ADE 20 27.644-22. 666-8.979 1.00 0.00 strl ATOM 620 C6 ADE 20 26.391-22. 555-9.457 1.00 0.00 strl ATOM 621 N6 ADE 20 25. 709-21. 429-9.253 1.00 0.00 strl ATOM 622 HN'ADE 20 26.134-20. 666-8.745 1.00 0.00 strl ATOM 623 HN"ADE 20 24.767-21. 337-9.607 1.00 0.00 strl ATOM 624 C5 ADE 20 25.867-23. 652-10.150 1. 00 0.00 strl ATOM 625 N7 ADE 20 24. 632-23. 882-10.765 1.00 0.00 strl ATOM 626 C8 ADE 20 24.785-25. 083-11.213 1.00 0.00 strl ATOM 627 H8 ADE 20 23.982-25. 594-11.736 1.00 0.00 strl ATOM 628 C2'ADE 20 26.278-27. 952-10. 089 1.00 0.00 strl ATOM 629 H2"ADE 20 26.255-27. 354-9.178 1.00 0.00 strl ATOM 630 02'ADE 20 27. 322-28. 932-10.032 1.00 0.00 strl ATOM 631 H2'ADE 20 26.903-29. 789-9.922 1.00 0.00 strl ATOM 632 C3'ADE 20 24.930-28. 595-10.336 1.00 0.00 strl ATOM 633 H3'ADE 20 24.101-27. 949-10.052 1.00 0.00 strl ATOM 634 03'ADE 20 24.939-29. 832-9.637 1.00 0.00 strl ATOM 635 P GUA 21 24.285-29. 952-8.173 1.00 0.00 strl ATOM 636 01P GUA 21 24.387-31. 359-7.727 1.00 0. 00 strl ATOM 637 02P GUA 21 22.974-29. 267-8. 187 1.00 0.00 strl ATOM 638 05'GUA 21 25.316-29. 067-7.310 1. 00 0.00 strl ATOM 639 C5'GUA 21 26.606-29. 576-6.977 1.00 0.00 strl ATOM 640 H5'GUA 21 27.171-29. 721-7.889 1.00 0.00 strl ATOM 641 H5''GUA 21 26.479-30. 539-6.461 1.00 0.00 strl ATOM 642 C4'GUA 21 27.415-28. 621-6.109 1.00 0.00 strl ATOM 643 H4'GUA 21 28.344-29. 094-5.805 1. 00 0.00 strl ATOM 644 04'GUA 21 27.711-27. 402-6.799 1.00 0.00 strl ATOM 645 Cl'GUA 21 27.779-26. 317-5.847 1.00 0.00 strl ATOM 646 H1'GUA 21 28.789-25. 911-5.824 1.00 0.00 strl ATOM 647 N9 GUA 21 26.820-25. 238-6.163 1.00 0.00 strl ATOM 648 C4 GUA 21 26.847-23. 949-5.670 1.00 0.00 strl ATOM 649 N3 GUA 21 27.792-23. 432-4.851 1.00 0.00 strl ATOM 650 C2 GUA 21 27.548-22. 153-4.540 1.00 0.00 strl ATOM 651 N2 GUA 21 28.380-21. 488-3.738 1.00 0.00 strl ATOM 652 HN'GUA 21 28.194-20. 523-3.505 1.00 0.00 strl ATOM 653 HN''GUA 21 29.197-21. 950-3.363 1.00 0.00 strl ATOM 654 N1 GUA 21 26.456-21. 448-5.005 1.00 0.00 strl ATOM 655 H1 GUA 21 26.342-20. 485-4.721 1.00 0.00 strl ATOM 656 C6 GUA 21 25.474-21. 956-5.846 1.00 0.00 strl ATOM 657 06 GUA 21 24.540-21. 242-6.205 1.00 0.00 strl ATOM 658 C5 GUA 21 25.725-23. 314-6.180 1.00 0.00 strl ATOM 659 N7 GUA 21 24.991-24. 186-6.988 1.00 0.00 strl ATOM 660 C8 GUA 21 25.694-25. 266-6.918 1.00 0.00 strl ATOM 661 H8 GUA 21 25.376-26. 175-7.420 1.00 0.00 strl ATOM 662 C2'GUA 21 27.442-26. 928-4.491 1.00 0.00 strl ATOM 663 H2''GUA 21 26.820-26. 242-3.920 1.00 0.00 strl ATOM 664 02'GUA 21 28.625-27. 281-3.763 1.00 0.00 strl ATOM 665 H2'GUA 21 28.357-27. 485-2.864 1.00 0.00 strl ATOM 666 C3'GUA 21 26.646-28. 156-4.892 1.00 0.00 strl ATOM 667 H3'GUA 21 25.607-27. 918-5.123 1.00 0. 00 strl ATOM 668 03'GUA 21 26.773-29. 142-3.864 1.00 0.00 strl ATOM 669 P ADE 22 25.461-29. 764-3.168 1. 00 0.00 strl ATOM 670 01P ADE 22 25.743-31. 176-2.824 1.00 0.00 strl ATOM 671 02P ADE 22 24.288-29. 429-4.006 1.00 0. 00 strl ATOM 672 05'ADE 22 25.359-28. 922-1.798 1.00 0.00 strl ATOM 673 C5'ADE 22 26.059-29. 348-0. 625 1.00 0.00 strl ATOM 674 H5'ADE 22 26. 886-29. 996-0.918 1.00 0.00 strl ATOM 675 H5''ADE 22 25. 376-29. 912 0.012 1.00 0.00 strl ATOM 676 C4'ADE 22 26.617-28. 160 0.160 1. 00 0.00 strl ATOM 677 H4'ADE 22 27.423-28. 497 0.809 1.00 0.00 strl ATOM 678 04'ADE 22 27.111-27. 138-0.714 1.00 0.00 strl ATOM 679 C1'ADE 22 26.741-25. 843-0.205 1.00 0.00 strl ATOM 680 Hl'ADE 22 27.631-25. 227-0.089 1.00 0.00 strl ATOM 681 N9 ADE 22 25.788-25. 165-1.100 1.00 0.00 strl ATOM 682 C4 ADE 22 25. 442-23.835-1. 068 1.00 0.00 strl ATOM 683 N3 ADE 22 25.928-22. 905-0.224 1.00 0.00 strl ATOM 684 C2 ADE 22 25. 387-21. 713-0.453 1. 00 0.00 strl ATOM 685 H2 ADE 22 25.720-20. 901 0.193 1.00 0.00 strl ATOM 686 N1 ADE 22 24.477-21. 404-1.382 1.00 0.00 strl ATOM 687 C6 ADE 22 24.006-22. 357-2.213 1.00 0.00 strl ATOM 688 N6 ADE 22 23.080-22. 047-3.120 1.00 0.00 strl ATOM 689 HN'ADE 22 22.712-22. 761-3.731 1.00 0.00 strl ATOM 690 HN''ADE 22 22.747-21. 097-3.195 1.00 0. 00 strl ATOM 691 C5 ADE 22 24.509-23. 652-2. 060 1.00 0.00 strl ATOM 692 N7 ADE 22 24.253-24. 851-2.731 1.00 0.00 strl ATOM 693 C8 ADE 22 25.037-25. 667-2.111 1.00 0.00 strl ATOM 694 H8 ADE 22 25.109-26. 714-2.405 1.00 0.00 strl ATOM 695 C2'ADE 22 26.112-26. 084 1.160 1.00 0.00 strl ATOM 696 H2"ADE 22 25.308-25. 365 1.340 1.00 0.00 strl ATOM 697 02'ADE 22 27.093-26. 037 2.201 1. 00 0.00 strl ATOM 698 H2'ADE 22 27.953-26. 148 1.789 1.00 0.00 strl ATOM 699 C3'ADE 22 25.542-27. 477 0.992 1.00 0.00 strl ATOM 700 H3'ADE 22 24.575-27. 465 0.486 1.00 0.00 strl ATOM 701 03'ADE 22 25.483-28. 102 2.277 1.00 0.00 strl ATOM 702 P ADE 23 24.215-27. 859 3.240 1.00 0.00 strl ATOM 703 01P ADE 23 22.984-28. 010 2.432 1.00 0.00 strl ATOM 704 02P ADE 23 24.399-28. 674 4.462 1.00 0. 00. strl ATOM 705 05'ADE 23 24.367-26. 307 3. 642 1.00 0.00 strl ATOM 706 C5'ADE 23 25.554-25. 843 4.290 1.00 0.00 strl ATOM 707 H5'ADE 23 26.420-26. 281 3.795 1.00 0.00 strl ATOM 708 H5''ADE 23 25.541-26. 169 5.331 1.00 0.00 strl ATOM 709 C4'ADE 23 25.672-24. 318 4.238 1.00 0.00 strl ATOM 710 H4'ADE 23 26.711-24. 028 4.388 1.00 0.00 strl ATOM 711 04'ADE 23 25.214-23. 794 2.991 1.00 0.00 strl ATOM 712 C1'ADE 23 24.582-22. 517 3.202 1.00 0.00 strl ATOM 713 H1'ADE 23 25.159-21. 741 2.704 1.00 0.00 strl ATOM 714 N9 ADE 23 23.203-22. 516 2.675 1.00 0.00 strl ATOM 715 C4 ADE 23 22.279-21. 500 2.788 1.00 0.00 strl ATOM 716 N3 ADE 23 22.477-20. 302 3.374 1.00 0.00 strl ATOM 717 C2 ADE 23 21.384-19. 548 3.316 1.00 0.00 strl ATOM 718 H2 ADE 23 21.465-18. 542 3.728 1.00 0.00 strl ATOM 719 N1 ADE 23 20.209-19. 870 2.774 1.00 0.00 strl ATOM 720 C6 ADE 23 20.035-21. 068 2.190 1.00 0.00 strl ATOM 721 N6 ADE 23 18.864-21. 349 1.617 1.00 0.00 strl ATOM 722 HN'ADE 23 18.110-20. 676 1.654 1.00 0.00 strl ATOM 723 HN''ADE 23 18.731-22. 232 1.146 1. 00 0.00 strl ATOM 724 C5 ADE 23 21.125-21. 950 2.187 1.00 0.00 strl ATOM 725 N7 ADE 23 21.300-23. 245 1.687 1.00 0.00 strl ATOM 726 C8 ADE 23 22.528-23. 487 2.013 1.00 0.00 strl ATOM 727 H8 ADE 23 23.006-24. 435 1.758 1.00 0.00 strl ATOM 728 C2'ADE 23 24.591-22. 261 4.711 1.00 0.00 strl ATOM 729 H2''ADE 23 23.624-21. 866 5.030 1.00 0.00 strl ATOM 730 02'ADE 23 25.652-21. 375 5.084 1.00 0.00 strl ATOM 731 H2'ADE 23 25.970-20. 956 4.281 1. 00 0. 00 strl ATOM 732 C3'ADE 23 24. 801-23.651 5.288 1.00 0.00 strl ATOM 733 H3'ADE 23 23.858-24. 178 5.439 1.00 0. 00 strl ATOM 734 03'ADE 23 25.561-23. 533 6.493 1.00 0.00 strl ATOM 735 P GUA 24 25.195-24. 432 7.778 1.00 0.00 strl ATOM 736 01P GUA 24 24.300-25. 526 7.339 1.00 0.00 strl ATOM 737 02P GUA 24 26.451-24. 748 8.495 1.00 0.00 strl ATOM 738 05'GUA 24 24.339-23. 415 8.686 1.00 0.00 strl ATOM 739 C5'GUA 24 24.999-22. 505 9.577 1.00 0.00 strl ATOM 740 H5'GUA 24 25.998-22. 306 9.213 1.00 0.00 strl ATOM 741 H5''GUA 24 25.053-22. 970 10.572 1.00 0.00 strl ATOM 742 C4'GUA 24 24.285-21. 163 9.667 1.00 0. 00 strl ATOM 743 H4'GUA 24 24.944-20. 428 10.128 1.00 0.00 strl ATOM 744 04'GUA 24 23.887-20. 693 8.375 1.00 0.00 strl ATOM 745 C1'GUA 24 22.564-20. 132 8.443 1.00 0.00 strl ATOM 746 H1'GUA 24 22. 582-19. 110 8. 063 1.00 0.00 strl ATOM 747 N9 GUA 24 21.606-20. 931 7.658 1.00 0.00 strl ATOM 748 C4 GUA 24 20.287-20. 622 7.419 1.00 0. 00 strl ATOM 749 N3 GUA 24 19.642-19. 517 7.853 1.00 0.00 strl ATOM 750 C2 GUA 24 18.364-19. 492 7.465 1.00 0.00 strl ATOM 751 N2 GUA 24 17.584-18. 469 7. 808 1.00 0.00 strl ATOM 752 HN'GUA 24 17.958-17. 711 8.361 1.00 0.00 strl ATOM 753 HN"GUA 24 16.618-18. 452 7.516 1.00 0.00 strl ATOM 754 N1 GUA 24 17.774-20. 484 6.707 1. O0 0.00 strl ATOM 755 Hl GUA 24 16.800-20. 392 6.457 1.00 0.00 strl ATOM 756 C6 GUA 24 18.415-21. 628 6.248 1.00 0.00 strl ATOM 757 06 GUA 24 17.799-22. 453 5.577 1.00 0.00 strl ATOM 758 C5 GUA 24 19. 776-21.. 663 6.657 1.00 0.00 strl ATOM 759 N7 GUA 24 20.762-22. 624 6.414 1.00 0.00 strl ATOM 760 C8 GUA 24 21.779-22. 118 7.028 1.00 0.00 strl ATOM 761 H8 GUA 24 22.741-22. 630 7.044 1. 00 0.00 strl ATOM 762 C2'GUA 24 22.174-20. 122 9.917 1.00 0.00 strl ATOM 763 H2"GUA 24 21.108-20. 338 10.023 1.00 0. 00 strl ATOM 764 02'GUA 24 22.512-18. 879 10.543 1.00 0.00 strl ATOM 765 H2'GUA 24 21.876-18. 226 10. 243 1.00 0.00 strl ATOM 766 C3'GUA 24 22.997-21. 268 10.470 1.00 0.00 strl ATOM 767 H3'GUA 24 22. 500-22. 230 10.334 1.00 0.00 strl ATOM 768 03'GUA 24 23.291-20. 995 11.843 1.00 0.00 strl ATOM 769 P ADE 25 22.412-21. 668 13.012 1.00 0.00 strl ATOM 770 O1P ADE 25 21.610-22. 761 12.420 1.00 0.00 strl ATOM 771 02P ADE 25 23.304-21. 944 14. 161 1. 00 0.00 strl ATOM 772 05'ADE 25 21.413-20. 476 13.426 1.00 0.00 strl ATOM 773 C5'ADE 25 21.864-19. 121 13.414 1.00 0.00 strl ATOM 774 H5'ADE 25 22.434-18. 944 12.502 1.00 0.00 strl ATOM 775 H5"ADE 25 22.512-18. 955 14.275 1.00 0.00 strl ATOM 776 C4'ADE 25 20.700-18. 136-13. 471 1.00 0.00 strl ATOM 777 H4'ADE 25 21.058-17. 166 13.811 1.00 0.00 strl ATOM 778 04'ADE 25 20.071-17. 985 12.191 1.00 0.00 strl ATOM 779 C1'ADE 25 18.640-17. 988 12.353 1.00 0.00 strl ATOM 780 Hl'ADE 25 18.210-17. 122 11.851 1.00 0.00 strl ATOM 781 N9 ADE 25 18.043-19. 224 11.812 1.00 0.00 strl ATOM 782 C4 ADE 25 16.734-19. 404 11.427 1.00 0.00 strl ATOM 783 N3 ADE 25 15.759-18. 475 11. 448 1.00 0.00 strl ATOM 784 C2 ADE 25 14.605-18. 973 11.015 1.00 0.00 strl ATOM 785 H2 ADE 25 13. 756-18.289 11.002 1.00 0. 00 strl ATOM 786 N1 ADE 25 14.371-20. 219 10.597 1. 00 0.00 strl ATOM 787 C6 ADE 25 15.361-21. 130 10.586 1.00 0.00 strl ATOM 788 N6 ADE 25 15.107-22. 372 10.173 1.00 0.00 strl ATOM 789 HN'ADE 25 14. 178-22. 623 9. 867 1.00 0.00 strl ATOM 790 HN''ADE 25 15.844-23. 063 10.167 1.00 0.00 strl ATOM 791 C5 ADE 25 16.623-20. 715 11.023 1.00 0.00 strl ATOM 792 N7 ADE 25 17. 849-21.377 11.143 1.00 0.00 strl ATOM 793 C8 ADE 25 18.606-20. 439 11.605 1.00 0.00 strl ATOM 794 H8 ADE 25 19.656-20. 621 11.829 1.00 0.00 strl ATOM 795 C2'ADE 25 18. 390-17.891 13.850 1.00 0.00 strl ATOM 796 H2''ADE 25 17.472-18. 418 14.113 1.00 0.00 strl ATOM 797 02'ADE 25 18.355-16. 529 14. 293 1.00 0.00 strl ATOM 798 H2'ADE 25 18.745-15. 993 13.599 1.00 0.00 strl ATOM 799 C3'ADE 25 19.595-18. 626 14.394 1.00 0.00 strl ATOM 800 H3'ADE 25 19. 468-19.709 14.348 1.00 0.00 strl ATOM 801 03'ADE 25 19.856-18. 162 15.721 1.00 0.00 strl ATOM 802 P CYT 26 19.553-19. 117 16.983 1.00 0.00 strl ATOM 803 O1P CYT 26 19.871-20. 510 16.596 1.00 0.00 strl ATOM 804 02P CYT 26 20.189-18. 519 18.179 1.00 0.00 strl ATOM 805 05'CYT 26 17.954-18. 990 17.145 1.00 0.00 strl ATOM 806 C5'CYT 26 17.385-17. 969 17.971 1.00 0.00 strl ATOM 807 H5'CYT 26 18.117-17. 169 18.100 1.00 0.00 strl ATOM 808 H5"CYT 26 17.155-18. 393 18.951 1.00 0.00 strl ATOM 809 C4'CYT 26 16.108-17. 381 17.352 1. 00 0. 00 strl ATOM 810 H4'CYT 26 16.019-16. 328 17.619 1.00 0.00 strl ATOM 811 04'CYT 26 16. 106-17. 501 15.923 1.00 0.00 strl ATOM 812 C1'CYT 26 14.764-17. 777 15.469 1.00 0.00 strl ATOM 813 H1'CYT 26 14.456-17. 014 14.752 1.00 0.00 strl ATOM 814 N1 CYT 26 14.667-19. 116 14.849 1.00 0.00 strl ATOM 815 C6 CYT 26 15.628-20. 062 15.062 1.00 0.00 strl ATOM 816 H6 CYT 26 16. 494-19.825 15.679 1.00 0.00 strl ATOM 817 C2 CYT 26 13.550-19. 382 14.068 1.00 0.00 strl ATOM 818 02 CYT 26 12.698-18. 513 13.896 1.00 0.00 strl ATOM 819 N3 CYT 26 13.429-20. 618 13.513 1.00 0.00 strl ATOM 820 C4 CYT 26 14.363-21. 557 13. 714 1.00 0.00 strl ATOM 821 N4 CYT 26 14.213-22. 759 13.158 1.00 0.00 strl ATOM 822 HN'CYT 26 13.401-22. 955 12.591 1.00 0.00 strl ATOM 823 HN''CYT 26 14. 912-23. 473 13.303 1.00 0.00 strl ATOM 824 C5 CYT 26 15.516-21. 288 14.517 1.00 0.00 strl ATOM 825 H5 CYT 26 16.273-22. 051 14.688 1.00 0.00 strl ATOM 826 C2'CYT 26 13.879-17. 704 16.709 1.00 0.00 strl ATOM 827 H2''CYT 26 13.062-18. 424 16.633 1.00 0.00 strl ATOM 828 02'CYT 26 13.384-16. 378 16.928 1.00 0.00 strl ATOM 829 H2'CYT 26 12.428-16. 411 16.839 1.00 0.00 strl ATOM 830 C3'CYT 26 14.854-18. 121 17.787 1.00 0.00 strl ATOM 831 H3'CYT 26 15.000-19. 202 17.811 1.00 0.00 strl ATOM 832 03'CYT 26 14.414-17. 596 19.041 1.00 0. 00 strl ATOM 833 P CYT 27 13.844-18. 586 20. 176 1.00 0.00 strl ATOM 834 01P CYT 27 14.640-19. 834 20.145 1.00 0.00 strl ATOM 835 02P CYT 27 13.717-17. 823 21.437 1.00 0. 00 strl ATOM 836 05'CYT 27 12.365-18. 918 19.635 1.00 0.00 strl ATOM 837 C5'CYT 27 11.501-17. 858 19.224 1.00 0.00 strl ATOM 838 H5'CYT 27 12.052-17. 189 18.562 1.00 0.00 strl ATOM 839 H5"CYT 27 11.182-17. 301 20.104 1. 00 0.00 strl ATOM 840 C4'CYT 27 10.267-18. 375 18.490 1.00 0.00 strl ATOM 841 H4'CYT 27 9.549-17. 565 18.372 1.00 0.00 strl ATOM 842 04'CYT 27 10.592-18. 904 17.206 1.00 0.00 strl ATOM 843 C1'CYT 27 9.694-19. 985 16.899 1.00 0.00 strl ATOM 844 HI'CYT 27 9.085-19. 719 16.038 1.00 0.00 strl ATOM 845 Nl CYT 27 10.435-21. 233 16.610 1.00 0.00 strl ATOM 846 C6 CYT 27 11.772-21. 342 16.875 1.00 0.00 strl ATOM 847 H6 CYT 27 12.307-20. 502 17.318 1.00 0.00 strl ATOM 848 C2 CYT 27 9.721-22. 285 16.055 1.00 0.00 strl ATOM 849 02 CYT 27 8. 518-22.164 15.833 1.00 0. 00 strl ATOM 850 N3 CYT 27 10.384-23. 441 15.774 1.00 0.00 strl ATOM 851 C4 CYT 27 11.694-23. 562 16.027 1.00 0. 00 strl ATOM 852 N4 CYT 27 12.314-24. 708 15.737 1.00 0.00 strl ATOM 853 HN'CYT 27 13.301-24. 808 15.922 1.00 0.00 strl ATOM 854 HN''CYT 27 11.795-25. 475 15.334 1.00 0.00 strl ATOM 855 C5 CYT 27 12.436-22. 481 16.600 1.00 0.00 strl ATOM 856 H5 CYT 27 13.502-22. 576 16.806 1.00 0.00 strl ATOM 857 C2'CYT 27 8.790-20. 160 18.116 1.00 0.00 strl ATOM 858 H2''CYT 27 8.642-21. 218 18.300 1.00 0.00 strl ATOM 859 02'CYT 27 7.537-19. 487 17.943 1.00 0.00 strl ATOM 860 H2'CYT 27 7.021-20. 002 17.319 1. 00 0.00 strl ATOM 861 C3'CYT 27 9.615-19. 529 19.228 1.00 0.00 strl ATOM 862 H3'CYT 27 10. 350-20.221 19.641 1. 00 0.00 strl ATOM 863 03'CYT 27 8.746-18. 976 20.232 1.00 0.00 strl ATOM 864 P GUA 28 8.462-19. 748 21.626 1.00 0.00 strl ATOM 865 O1P GUA 28 7.772-18. 808 22.538 1.00 0.00 strl ATOM 866 02P GUA 28 9.722-20. 395 22.056 1.00 0.00 strl ATOM 867 05'GUA 28 7.418-20. 908 21.223 1.00 0.00 strl ATOM 868 C5'GUA 28 6.019-20. 600 21.115 1.00 0.00 strl ATOM 869 H5'GUA 28 5.868-19. 818 20.383 1.00 0.00 strl ATOM 870 H5"GUA 28 5.677-20. 248 22.098 1.00 0.00 strl ATOM 871 C4'GUA 28 5.174-21. 788 20.682 1.00 0.00 strl ATOM 872 H4'GUA 28 4.119-21. 522 20.698 1.00 0.00 strl ATOM 873 04'GUA 28 5.530-22. 229 19.363 1.00 0. 00 strl ATOM 874 C1'GUA 28 5.340-23. 659 19.276 1. 00 0.00 strl ATOM 875 Hl'GUA 28 4. 598-23. 876 18.516 1.00 0.00 strl ATOM 876 N9 GUA 28 6. 584-24. 384 18.971 1.00 0.00 strl ATOM 877 C4 GUA 28 6.680-25. 701 18.584 1.00 0.00 strl ATOM 878 N3 GUA 28 5. 641-26. 538 18.361 1.00 0.00 strl ATOM 879 C2 GUA 28 6.045-27. 760 18.003 1.00 0.00 strl ATOM 880 N2 GUA 28 5.150-28. 715 17.747 1.00 0.00 strl ATOM 881 HN'GUA 28 4.163-28. 515 17.823 1.00 0.00 strl ATOM 882 HN''GUA 28 5.459-29. 637 17.477 1.00 0. 00 strl ATOM 883 N1 GUA 28 7.370-28. 119 17.877 1.00 0.00 strl ATOM 884 H1 GUA 28 7.590-29. 066 17.614 1.00 0.00 strl ATOM 885 C6 GUA 28 8.454-27. 278 18.098 1.00 0.00 strl ATOM 886 06 GUA 28 9.600-27. 698 17.955 1.00 0. 00 strl ATOM 887 C5 GUA 28 8.033-25. 977 18.480 1.00 0.00 strl ATOM 888 N7 GUA 28 8.791-24. 846 18.795 1.00 0.00 strl ATOM 889 C8 GUA 28 7.871-23. 982 19.065 1. 00 0.00 strl ATOM 890 H8 GUA 28 8.118-22. 976 19.382 1. 00 0.00 strl ATOM 891 C2'GUA 28 4.824-24. 092 20.636 1. 00 0. 00 strl ATOM 892 H2''GUA 28 5.213-25. 078 20.906 1.00 0.00 strl ATOM 893 02'GUA 28 3.392-24. 078 20. 679 1. 00 0.00 strl ATOM 894 H2'GUA 28 3.078-24. 467 19.859 1. 00 0.00 strl ATOM 895 C3'GUA 28 5.412-23. 022 21.531 1.00 0. 00 strl ATOM 896 H3'GUA 28 6. 463-23. 191 21.752 1.00 0.00 strl ATOM 897 03'GUA 28 4.594-23. 000 22.688 1.00 0.00 strl ATOM 898 P CYT 29 5.052-23. 769 24. 023 1.00 0.00 strl ATOM 899 01P CYT 29 6.471-23. 443 24.291 1.00 0.00 strl ATOM 900 02P CYT 29 4.026-23. 554 25.067 1.00 0.00 strl ATOM 901 05'CYT 29 4.964-25. 297 23.524 1.00 0.00 strl ATOM 902 C5'CYT 29 3.705-25. 923 23.342 1.00 0.00 strl ATOM 903 H5'CYT 29 3.176-25. 384 22.554 1.00 0.00 strl ATOM 904 H5''CYT 29 3.134-25. 863 24.269 1.00 0.00 strl ATOM 905 C4'CYT 29 3.841-27. 388 22.924 1.00 0.00 strl ATOM 906 H4'CYT 29 2.862-27. 853 22.872 1.00 0.00 strl ATOM 907 04'CYT 29 4.485-27. 503 21.650 1.00 0.00 strl ATOM 908 C1'CYT 29 5.230-28. 741 21.602 1.00 0.00 strl ATOM 909 Hl'CYT 29 4. 828-29. 379 20.813 1.00 0.00 strl ATOM 910 N1 CYT 29 6.680-28. 526 21.388 1.00 0.00 strl ATOM 911 C6 CYT 29 7.270-27. 328 21.666 1.00 0.00 strl ATOM 912 H6 CYT 29 6.663-26. 495 22.014 1.00 0.00 strl ATOM 913 C2 CYT 29 7.426-29. 616 20.962 1.00 0.00 strl ATOM 914 02 CYT 29 6.870-30. 686 20.727 1.00 0.00 strl ATOM 915 N3 CYT 29 8.771-29. 468 20. 822 1.00 0.00 strl ATOM 916 C4 CYT 29 9.364-28. 300 21.090 1.00 0.00 strl ATOM 917 N4 CYT 29 10.682-28. 184 20.932 1.00 0.00 strl ATOM 918 HN'CYT 29 11.139-27. 304 21.126 1.00 0.00 strl ATOM 919 HN''CYT 29 11.225-28. 976 20.619 1.00 0.00 strl ATOM 920 C5 CYT 29 8.603-27. 174 21.534 1.00 0.00 strl ATOM 921 H5 CYT 29 9.089-26. 233 21.783 1. 00 0.00 strl ATOM 922 C2'CYT 29 5.017-29. 397 22.961 1.00 0.00 strl ATOM 923 H2''CYT 29 5.926-29. 905 23.284 1.00 0.00 strl ATOM 924 02'CYT 29 3.900-30. 294 22.944 1.00 0.00 strl ATOM 925 H2'CYT 29 3.712-30. 498 22.025 1.00 0.00 strl ATOM 926 C3'CYT 29 4.747-28. 186 23.834 1.00 0.00 strl ATOM 927 H3'CYT 29 5.659-27. 648 24.097 1.00 0.00 strl ATOM 928 03'CYT 29 4.006-28. 623 24.974 1.00 0. 00 strl ATOM 929 P CYT 30 4.765-29. 016 26.338 1.00 0.00 strl ATOM 930 01P CYT 30 5.806-27. 998 26.602 1.00 0.00 strl ATOM 931 02P CYT 30 3.745-29. 315 27.368 1.00 0.00 strl ATOM 932 05'CYT 30 5.494-30. 393 25.934 1.00 0.00 strl ATOM 933 C5'CYT 30 4. 754-31. 610 25.856 1. 00 0.00 strl ATOM 934 H5'CYT 30 4.013-31. 519 25.059 1.00 0.00 strl ATOM 935 H5''CYT 30 4.240-31. 776 26.802 1.00 0.00 strl ATOM 936 C4'CYT 30 5.658-32. 807 25.561 1.00 0.00 strl ATOM 937 H4'CYT 30 5.057-33. 709 25.466 1.00 0.00 strl ATOM 938 04'CYT 30 6. 408-32. 611 24.367 1.00 0.00 strl ATOM 939 Cl'CYT 30 7.661-33. 310 24.468 1.00 0.00 strl ATOM 940 Hl'CYT 30 7.671-34. 140 23.761 1.00 0.00 strl ATOM 941 N1 CYT 30 8.801-32. 408 24.198 1.00 0.00 strl ATOM 942 C6 CYT 30 8.650-31. 055 24.267 1.00 0.00 strl ATOM 943 H6 CYT 30 7.685-30. 636 24.536 1.00 0.00 strl ATOM 944 C2 CYT 30 10.028-32. 985 23. 897 1. 00 0.00 strl ATOM 945 02 CYT 30 10.140-34. 210 23.839 1.00 0.00 strl ATOM 946 N3 CYT 30 11.088-32. 161 23.664 1.00 0.00 strl ATOM 947 C4 CYT 30 10.951-30. 830 23.724 1.00 0.00 strl ATOM 948 N4 CYT 30 12.005-30. 051 23.484 1.00 0.00 strl ATOM 949 HN'CYT 30 11.911-29. 046 23.525 1.00 0.00 strl ATOM 950 HN''CYT 30 12.897-30. 465 23.254 1.00 0.00 strl ATOM 951 C5 CYT 30 9.691-30. 234 24.037 1. 00 0.00 strl ATOM 952 H5 CYT 30 9.576-29. 151 24. 088 1.00 0.00 strl ATOM 953 C2'CYT 30 7.734-33. 850 25.899 1.00 0.00 strl ATOM 954 H2"CYT 30 8.731-33. 676 26.314 1.00 0.00 strl ATOM 955 02'CYT 30 7.395-35. 241 25.952 1.00 0.00 strl ATOM 956 H2'CYT 30 8.103-35. 690 26.420 1.00 0.00 strl ATOM 957 C3'CYT 30 6.709-32. 999 26.634 1.00 0.00 strl ATOM 958 H3'CYT 30 7.147-32. 035 26.910 1. 00 0.00 strl ATOM 959 03'CYT 30 6.181-33. 677 27.779 1.00 0.00 strl ATOM 960 H3T CYT 30 6.775-34. 404 27.980 1.00 0.00 strl END

Appendix II: co-ordinates of IIIbca. pdb ATOM 1 05'GUA 1 18.030-8. 032 12.035 1.00 0.00 O ATOM 2 C5'GUA 1 18.732-9. 221 11.665 1.00 0.00 C ATOM 3 C4'GUA 1 18.790-10. 222 12.816 1.00 0.00 C ATOM 4 04'GUA 1 19.366-9. 638 13.995 1.00 0. 00 0 ATOM 5 C1'GUA 1 18.567-9. 986 15.143 1.00 0.00 C ATOM 6 N9 GUA 1 17.805-8. 823 15.640 1.00 0.00 N ATOM 7 C4 GUA 1 17.301-8. 653 16.910 1.00 0.00 C ATOM 8 N3 GUA 1 17.418-9. 528 17. 935 1.00 0.00 N ATOM 9 C2 GUA 1 16.824-9. 084 19.047 1.00 0.00 C ATOM 10 N2 GUA 1 16.838-9. 829 20.152 1.00 0.00 N ATOM 11 N1 GUA 1 16.170-7. 872 19.135 1.00 0.00 N ATOM 12 C6 GUA 1 16.037-6. 958 18.099 1.00 0.00 C ATOM 13 06 GUA 1 15.433-5. 904 18.279 1.00 0.00 O ATOM 14 C5 GUA 1 16.664-7. 421 16.912 1.00 0.00 C ATOM 15 N7 GUA 1 16.760-6. 815 15.657 1.00 0.00 N ATOM 16 C8 GUA 1 17.431-7. 693 14.992 1.00 0.00 C ATOM 17 C2'GUA 1 17.632-11. 088 14.671 1.00 0.00 C ATOM 18 02'GUA 1 18.253-12. 376 14.753 1.00 0.00 O ATOM 19 C3'GUA 1 17.397-10. 666 13.235 1.00 0.00 C ATOM 20 03'GUA 1 17.029-11. 819 12.471 1.00 0.00 O ATOM 21 H5'GUA 1 18.637-7. 489 12.543 1.00 0.00 H ATOM 22 1H5'GUA 1 19.748-8. 957 11.373 1.00 0.00 H ATOM 23 2H5'GUA 1 18.227-9. 683 10.816 1.00 0.00 H ATOM 24 H4'GUA 1 19.378-11. 090 12.520 1.00 0.00 H ATOM 25 H1'GUA 1 19.213-10. 368 15.935 1.00 0.00 H ATOM 26 1H2 GUA 1 17.297-10. 729 20.149 1.00 0.00 H ATOM 27 2H2 GUA 1 16.391-9. 493 20.993 1.00 0.00 H ATOM 28 H1 GUA 1 15.751-7. 607 20. 013 1.00 0.00 H ATOM 29 H8 GUA 1 17.681-7. 535 13.944 1.00 0.00 H ATOM 30 H2'GUA 1 16.696-11. 061 15.237 1.00 0.00 H ATOM 31 H02'GUA 1 18.295-12. 613 15.682 1.00 0.00 H ATOM 32 H3'GUA 1 16.667-9. 859 13.160 1.00 0.00 H ATOM 33 P GUA 2 15.492-12. 297 12.404 1.00 0.00 P ATOM 34 01P GUA 2 15.436-13. 572 11.654 1.00 0.00 0 ATOM 35 02P GUA 2 14.667-11. 148 11.968 1. 00 0. 00 0 ATOM 36 05'GUA 2 15.153-12. 604 13.948 1.00 0.00 0 ATOM 37 C5'GUA 2 15.721-13. 740 14.606 1.00 0.00 C ATOM 38 C4'GUA 2 15.361-13. 772 16.088 1.00 0.00 C ATOM 39 04'GUA 2 15.839-12. 617 16. 783 1.00 0.00 0 ATOM 40 C1'GUA 2 14.893-12. 258 17.812 1.00 0.00 C ATOM 41 N9 GUA 2 14.372-10. 890 17.613 1. 00 0.00 N ATOM 42 C4 GUA 2 13.821-10. 073 18.577 1.00 0.00 C ATOM 43 N3 GUA 2 13.660-10. 384 19.883 1. 00 0. 00 N ATOM 44 C2 GUA 2 13.096-9. 389 20.575 1.00 0.00 C ATOM 45 N2 GUA 2 12.865-9. 531 21.880 1. 00 0.00 N ATOM 46 Nl GUA 2 12.723-8. 183 20.015 1.00 0.00 N ATOM 47 C6 GUA 2 12. 876-7.841 18.679 1.00 0.00 C ATOM 48 06 GUA 2 12.508-6. 739 18.279 1.00 0.00 0 ATOM 49 C5 GUA 2 13.475-8. 893 17.935 1.00 0. 00 C ATOM 50 N7 GUA 2 13.802-8. 957 16.578 1.00 0.00 N ATOM 51 C8 GUA 2 14.312-10. 139 16.484 1.00 0.00 C ATOM 52 C2'GUA 2 13.767-13. 290 17.736 1.00 0.00 C ATOM 53 02'GUA 2 13.988-14. 378 18.642 1.00 0.00 0 ATOM 54 C3'GUA 2 13. 862-13. 736 16.291 1.00 0.00 C ATOM 55 03'GUA 2 13.350-15. 067 16.178 1.00 0. 00 0 ATOM 56 1H5'GUA 2 16. 806-13.707 14.503 1.00 0.00 H ATOM 57 2H5'GUA 2 15.347-14. 648 14.131 1.00 0.00 H ATOM 58 H4'GUA 2 15. 774-14. 668 16.549 1.00 0. 00 H

ATOM 59 Hl'GUA 2 15.378-12. 324 18.787 1.00 0.00 H ATOM 60 1H2 GUA 2 13.115-10. 391 22.346 1.00 0.00 H ATOM 61 2H2 GUA 2 12.440-8. 778 22.403 1.00 0.00 H ATOM 62 Hl GUA 2 12.306-7. 479 20.607 1.00 0. 00 H ATOM 63 H8 GUA 2 14.682-10. 519 15.532 1.00 0.00 H ATOM 64 H2'GUA 2 12.803-12. 811 17.924 1.00 0.00 H ATOM 65 H02'GUA 2 13.791-14. 058 19.525 1.00 0.00 H ATOM 66 H3'GUA 2 13.371-13. 036 15.613 1.00 0.00 H ATOM 67 P CYT 3 11.801-15. 315 15.818 1.00 0.00 P ATOM 68 01P CYT 3 11.402-14. 333 14.785 1.00 0. 00 0 ATOM 69 02P CYT 3 11.606-16. 762 15.575 1.00 0.00 0 ATOM 70 05'CYT 3 11.061-14. 928 17.193 1.00 0.00 0 ATOM 71 C5'CYT 3 11.069-15. 832 18.300 1.00 0.00 C ATOM 72 C4'CYT 3 10.419-15. 214 19.534 1.00 0.00 C ATOM 73 04'CYT 3 11.140-14. 063 19.998 1.00 0.00 O ATOM 74 C1'CYT 3 10.202-13. 034 20.375 1.00 0.00 C ATOM 75 N1 CYT 3 10.257-11. 885 19.442 1.00 0.00 N ATOM 76 C6 CYT 3 10.469-12. 074 18.107 1.00 0.00 C ATOM 77 C2 CYT 3 10.070-10. 615 19.972 1.00 0.00 C ATOM 78 02 CYT 3 9.880-10. 468 21.177 1.00 0.00 0 ATOM 79 N3 CYT 3 10.102-9. 551 19.123 1.00 0. 00 N ATOM 80 C4 CYT 3 10.308-9. 724 17.811 1.00 0.00 C ATOM 81 N4 CYT 3 10.332-8. 661 17.007 1.00 0.00 N ATOM 82 C5 CYT 3 10.502-11. 030 17.262 1.00 0.00 C ATOM 83 C2'CYT 3 8.830-13. 697 20.341 1.00 0.00 C ATOM 84 02'CYT 3 8.526-14. 345 21.583 1.00 0.00 0 ATOM 85 C3'CYT 3 9.027-14. 694 19.221 1.00 0.00 C ATOM 86 03'CYT 3 8.086-15. 760 19.372 1.00 0.00 0 ATOM 87 1H5'CYT 3 12.099-16. 098 18.537 1.00 0.00 H ATOM 88 2H5'CYT 3 10.522-16. 734 18.025 1.00 0.00 H ATOM 89 H4'CYT 3 10.365-15. 952 20.332 1.00 0.00 H ATOM 90 H1'CYT 3 10.420-12. 695 21.389 1.00 0. 00 H ATOM 91 H6 CYT 3 10.618-13. 083 17.722 1.00 0.00 H ATOM 92 1H4 CYT 3 10.487-8. 781 16.016 1.00 0.00 H ATOM 93 2H4 CYT 3 10.189-7. 737 17.388 1.00 0. 00 H ATOM 94 H5 CYT 3 10.665-11. 176 16.195 1.00 0.00 H ATOM 95 H2'CYT 3 8.060-12. 968 20.075 1.00 0.00 H ATOM 96 H02'CYT 3 9.255-14. 937 21.781 1.00 0.00 H ATOM 97 H3'CYT 3 8.976-14. 220 18.238 1.00 0.00 H ATOM 98 P GUA 4 6.689-15. 726 18.572 1.00 0.00 P ATOM 99 01P GUA 4 5.928-16. 948 18.915 1.00 0.00 O ATOM 100 02P GUA 4 6.974-15. 408 17.154 1.00 0. 00 O ATOM 101 05'GUA 4 5.940-14. 462 19.232 1.00 0.00 O ATOM 102 C5'GUA 4 5.553-14. 493 20.608 1.00 0.00 C ATOM 103 C4'GUA 4 5. 320-13. 093 21.171 1.00 0.00 C ATOM 104 04'GUA 4 6.451-12. 238 20.987 1.00 0.00 0 ATOM 105 C1'GUA 4 5.984-10. 877 20.863 1.00 0.00 C ATOM 106 N9 GUA 4 6.428-10. 251 19.601 1.00 0.00 N ATOM 107 C4 GUA 4 6.230-8. 941 19.239 1.00 0.00 C ATOM 108 N3 GUA 4 5.631-7. 998 19.998 1.00 0.00 N ATOM 109 C2 GUA 4 5.575-6. 815 19.384 1.00 0.00 C ATOM 110 N2 GUA 4 5.017-5. 775 20.001 1.00 0.00 N ATOM 111 N1 GUA 4 6.073-6. 586 18.117 1.00 0.00 N ATOM 112 C6 GUA 4 6.695-7. 538 17.316 1.00 0. 00 C ATOM 113 06 GUA 4 7.104-7. 231 16.198 1.00 0.00 0 ATOM 114 C5 GUA 4 6.758-8. 802 17.965 1.00 0.00 C ATOM 115 N7 GUA 4 7.291-10. 016 17.521 1.00 0.00 N ATOM 116 C8 GUA 4 7.057-10. 791 18.528 1.00 0.00 C ATOM 117 C2'GUA 4 4.456-10. 946 20.913 1.00 0.00 C ATOM 118 02'GUA 4 3. 966-10. 732 22.241 1.00 0.00 O

ATOM 119 C3'GUA 4 4.207-12. 366 20.449 1.00 0.00 C ATOM 120 03'GUA 4 2.946-12. 806 20.960 1.00 0.00 O ATOM 121 1H5'GUA 4 6. 338-14. 980 21.186 1.00 0.00 H ATOM 122 2H5'GUA 4 4.633-15. 071 20.704 1.00 0.00 H ATOM 123 H4'GUA 4 5.089-13. 157 22.233 1.00 0. 00 H ATOM 124 H1'GUA 4 6.347-10. 291 21.708 1.00 0.00 H ATOM 125 1H2 GUA 4 4.638-5. 884 20. 931 1.00 0.00 H ATOM 126 2H2 GUA 4 4.968-4. 881 19.538 1.00 0.00 H ATOM 127 Hl GUA 4 5.981-5. 663 17. 716 1.00 0.00 H ATOM 128 H8 GUA 4 7.351-11. 840 18.513 1.00 0.00 H ATOM 129 H2'GUA 4 4. 019-10. 232 20.210 1.00 0.00 H ATOM 130 H02'GUA 4 3.119-11. 179 22.307 1.00 0.00 H ATOM 131 H3'GUA 4 4.285-12. 462 19. 364 1.00 0.00 H ATOM 132 P CYT 5 1.579-12. 377 20.223 1.00 0.00 P ATOM 133 01P CYT 5 0.459-13. 103 20.862 1.00 0.00 0 ATOM 134 02P CYT 5 1.786-12. 481 18.761 1.00 0.00 0 ATOM 135 05'CYT 5 1.453-10. 816 20.602 1.00 0.00 0 ATOM 136 C5'CYT 5 0.848-10. 411 21. 834 1.00 0.00 C ATOM 137 C4'CYT 5 0.326-8. 980 21.758 1.00 0.00 C ATOM 138 04'CYT 5 1.383-8. 034 21. 561 1.00 0.00 0 ATOM 139 C1'CYT 5 0. 944-7. 007 20. 649 1.00 0.00 C ATOM 140 Nl CYT 5 1.734-7. 025 19.398 1.00 0.00 N ATOM 141 C6 CYT 5 2.225-8. 195 18.892 1.00 0.00 C ATOM 142 C2 CYT 5 1.945-5. 812 18.753 1.00 0.00 C ATOM 143 02 CYT 5 1.496-4. 771 19.228 1.00 0.00 0 ATOM 144 N3 CYT 5 2.657-5. 814 17.593 1.00 0.00 N ATOM 145 C4 CYT 5 3.143-6. 953 17.086 1.00 0. 00 C ATOM 146 N4 CYT 5 3.833-6. 916 15.947 1.00 0.00 N ATOM 147 C5 CYT 5 2.930-8. 204 17. 746 1.00 0.00 C ATOM 148 C2'CYT 5-0.531-7. 292 20.369 1.00 0.00 C ATOM 149 02'CYT 5-1.386-6. 610 21.294 1.00 0.00 0 ATOM 150 C3'CYT 5-0. 584-8. 794 20.559 1.00 0.00 C ATOM 151 03'CYT 5-1.912-9. 174 20.929 1.00 0.00 O ATOM 152 1H5'CYT 5 1.584-10. 479 22.635 1.00 0.00 H ATOM 153 2H5'CYT 5 0.017-11. 079 22.058 1.00 0.00 H ATOM 154 H4'CYT 5-0.213-8. 734 22.671 1.00 0.00 H ATOM 155 H1'CYT 5 1.041-6. 032 21.127 1.00 0.00 H ATOM 156 H6 CYT 5 2.047-9. 130 19.424 1.00 0.00 H ATOM 157 1H4 CYT 5 3.986-6. 035 15.478 1.00 0.00 H ATOM 158 2H4 CYT 5 4.202-7. 769 15.552 1.00 0.00 H ATOM 159 H5 CYT 5 3.324-9. 134 17.336 1.00 0.00 H ATOM 160 H2'CYT 5-0. 776-7. 030 19.336 1.00 0.00 H ATOM 161 H02'CYT 5-1.110-6. 864 22.178 1.00 0.00 H ATOM 162 H3'CYT 5-0.221-9. 329 19.680 1.00 0. 00 H ATOM 163 P URI 6-2.875-9. 905 19.865 1.00 0.00 P ATOM 164 O1P URI 6-4.024-10. 481 20.599 1.00 0.00 0 ATOM 165 02P URI 6-2. 042-10.772 19.001 1.00 0.00 0 ATOM 166 05'URI 6-3.407-8. 673 18.977 1.00 0.00 0 ATOM 167 C5'URI 6-4. 352-7. 748 19.520 1.00 0.00 C ATOM 168 C4'URI 6-4.478-6. 496 18.658 1.00 0.00 C ATOM 169 04'URI 6-3.229-5. 809 18.528 1.00 0.00 0 ATOM 170 C1'URI 6-3.137-5. 238 17. 206 1.00 0.00 C ATOM 171 N1 URI 6-1.982-5. 784 16.456 1.00 0.00 N ATOM 172 C6 URI 6-1.495-7. 038 16.717 1.00 0.00 C ATOM 173 C2 URI 6-1.414-4. 977 15.484 1.00 0.00 C ATOM 174 02 URI 6-1.842-3. 852 15. 232 1.00 0.00 0 ATOM 175 N3 URI 6-0.336-5. 511 14.804 1.00 0.00 N ATOM 176 C4 URI 6 0.219-6. 762 15.005 1.00 0.00 C ATOM 177 04 URI 6 1.183-7. 133 14.340 1.00 0. 00 O ATOM 178 C5 URI 6-0.435-7. 538 16.036 1.00 0. 00 C

ATOM 179 C2'URI 6-4.454-5. 572 16.508 1. 00 0.00 C ATOM 180 02'URI 6-5.415-4. 524 16.679 1. 00 0.00 0 ATOM 181 C3'URI 6-4.869-6. 836 17.233 1.00 0.00 C ATOM 182 03'URI 6-6.294-6. 968 17.162 1.00 0.00 0 ATOM 183 1H5'URI 6-4.033-7. 458 20.521 1.00 0.00 H ATOM 184 2H5'URI 6-5.326-8. 233 19.585 1.00 0.00 H ATOM 185 H4'URI 6-5.215-5. 822 19.091 1.00 0.00 H ATOM 186 Hl'URI 6-3.038-4. 156 17.287 1.00 0.00 H ATOM 187 H6 URI 6-1.971-7. 647 17.485 1.00 0.00 H ATOM 188 H3 URI 6 0.086-4. 933 14.090 1.00 0.00 H ATOM 189 H5 URI 6-0.070-8. 539 16.268 1.00 0.00 H ATOM 190 H2'URI 6-4.279-5. 777 15.452 1.00 0.00 H ATOM 191 H02'URI 6-5.147-3. 796 16.113 1.00 0.00 H ATOM 192 H3'URI 6-4.342-7. 715 16.859 1.00 0.00 H ATOM 193 P CYT 7-6.986-7. 747 15.932 1. 00 0. 00 P ATOM 194 01P CYT 7-6.193-8. 964 15.648 1.00 0.00 0 ATOM 195 02P CYT 7-8.435-7. 860 16.212 1.00 0.00 0 ATOM 196 05'CYT 7-6.788-6. 721 14.707 1.00 0.00 0 ATOM 197 C5'CYT 7-7.346-5. 405 14.767 1.00 0.00 C ATOM 198 C4'CYT 7-6. 715-4. 476 13. 734 1.00 0.00 C ATOM 199 04'CYT 7-5. 286-4. 471 13.826 1.00 0.00 O ATOM 200 Cl'CYT 7-4.727-4. 333 12.503 1.00 0.00 C ATOM 201 Nl CYT 7-3. 885-5.495 12.134 1.00 0.00 N ATOM 202 C6 CYT 7-3.839-6. 617 12.912 1.00 0.00 C ATOM 203 C2 CYT 7-3.151-5. 400 10.959 1.00 0.00 C ATOM 204 02 CYT 7-3.206-4. 380 10.276 1. 00 0.00 0 ATOM 205 N3 CYT 7-2.379-6. 457 10.591 1.00 0.00 N ATOM 206 C4 CYT 7-2.324-7. 563 11.342 1.00 0.00 C ATOM 207 N4 CYT 7-1.563-8. 581 10.945 1.00 0.00 N ATOM 208 C5 CYT 7-3.075-7. 667 12.556 1.00 0.00 C ATOM 209 C2'CYT 7-5.915-4. 203 11.552 1.00 0.00 C ATOM 210 02'CYT 7-6.261-2. 830 11.332 1.00 0.00 0 ATOM 211 C3'CYT 7-6.997-4. 937 12.318 1.00 0.00 C ATOM 212 03'CYT 7-8. 274-4.435 11.911 1.00 0.00 0 ATOM 213 1H5'CYT 7-7.179-4. 994 15.763 1.00 0. 00 H ATOM 214 2H5'CYT 7-8.419-5. 465 14.583 1.00 0.00 H ATOM 215 H4'CYT 7-7.088-3. 462 13.873 1.00 0.00 H ATOM 216 H1'CYT 7-4.128-3. 422 12.459 1.00 0.00 H ATOM 217 H6 CYT 7-4.432-6. 668 13.823 1.00 0.00 H ATOM 218 1H4 CYT 7-1.516-9. 424 11.500 1.00 0.00 H ATOM 219 2H4 CYT 7-1.036-8. 512 10.084 1.00 0.00 H ATOM 220 H5 CYT 7-3.027-8. 563 13.175 1.00 0.00 H ATOM 221 H2'CYT 7-5.703-4. 712 10.608 1.00 0. 00 H ATOM 222 H02'CYT 7-5.541-2. 430 10.838 1.00 0.00 H ATOM 223 H3'CYT 7-6.912-6. 020 12.211 1.00 0.00 H ATOM 224 P ADE 8-9.044-5. 082 10.652 1.00 0.00 P ATOM 225 01P ADE 8-9.129-6. 544 10.862 1.00 0.00 0 ATOM 226 02P ADE 8-10.276-4. 299 10.409 1.00 0.00 0 ATOM 227 05'ADE 8-8.024-4. 809 9.435 1.00 0.00 0 ATOM 228 C5'ADE 8-7.763-3. 476 8.986 1.00 0.00 C ATOM 229 C4'ADE 8-6.797-3. 459 7.804 1.00 0.00 C ATOM 230 04'ADE 8-5.538-4. 065 8.142 1.00 0.00 0 ATOM 231 Cl'ADE 8-5.153-4. 984 7.102 1.00 0. 00 C ATOM 232 N9 ADE 8-5.327-6. 387 7.533 1.00 0.00 N ATOM 233 C4 ADE 8-4.868-7. 514 6.886 1.00 0. 00 C ATOM 234 N3 ADE 8-4.168-7. 550 5.732 1.00 0.00 N ATOM 235 C2 ADE 8-3.881-8. 801 5.379 1.00 0.00 C ATOM 236 N1 ADE 8-4. 208-9. 918 6.031 1.00 O. 00 N ATOM 237 C6 ADE 8-4.906-9. 857 7.178 1.00 0. 00 C ATOM 238 N6 ADE 8-5.221-10. 985 7.814 1.00 0. 00 N

ATOM 239 C5'ADE 8-5.265-8. 589 7.648 1.00 0.00 C ATOM 240 N7 ADE 8-5.974-8. 164 8.776 1.00 0.00 N ATOM 241 C8 ADE 8-5. 960-6. 883 8. 625 1.00 0.00 C ATOM 242 C2'ADE 8-6. 056-4. 661 5.923 1.00 0.00 C ATOM 243 02'ADE 8-5.539-3. 574 5.145 1.00 0.00 0 ATOM 244 C3'ADE 8-7.332-4. 281 6.642 1.00 0.00 C ATOM 245 03'ADE 8-8. 108-3. 434 5.787 1.00 0.00 0 ATOM 246 1H5'ADE 8-7.333-2. 901 9.806 1.00 0.00 H ATOM 247 2H5'ADE 8-8.703-3. 013 8.683 1. 00 0.00 H ATOM 248 H4'ADE 8-6.628-2. 433 7.482 1.00 0.00 H ATOM 249 H1'ADE 8-4.114-4. 811 6.825 1.00 0.00 H ATOM 250 H2 ADE 8-3.317-8. 929 4.454 1.00 0.00 H ATOM 251 1H6 ADE 8-4.937-11. 876 7.432 1.00 0.00 H ATOM 252 2H6 ADE 8-5.743-10. 949 8.678 1.00 0.00 H ATOM 253 H8 ADE 8-6. 449-6.224 9.341 1.00 0.00 H ATOM 254 H2'ADE 8-6.211-5. 551 5.308 1.00 0.00 H ATOM 255 H02'ADE 8-5.418-2. 830 5.739 1.00 0.00 H ATOM 256 H3'ADE 8-7.885-5. 159 6.979 1.00 0.00 H ATOM 257 P ADE 9-9.699-3. 279 6.001 1.00 0.00 P ATOM 258 O1P ADE 9-9.934-2. 675 7.331 1.00 0.00 0 ATOM 259 02P ADE 9-10.265-2. 641 4.792 1.00 0.00 0 ATOM 260 05'ADE 9-10.204-4. 810 6.046 1.00 0.00 0 ATOM 261 C5'ADE 9-11.604-5. 112 6.020 1.00 0.00 C ATOM 262 C4'ADE 9-11.869-6. 618 6.024 1.00 0.00 C ATOM 263 04'ADE 9-11. 194-7.271 4.944 1.00 0.00 0 ATOM 264 C1'ADE 9-10.055-7. 993 5. 444 1.00 0.00 C ATOM 265 N9 ADE 9-8.850-7. 666 4.662 1.00 0.00 N ATOM 266 C4 ADE 9-8.057-8. 542 3.959 1.00 0.00 C ATOM 267 N3 ADE 9-8.227-9. 873 3.863 1.00 0.00 N ATOM 268 C2 ADE 9-7.286-10. 425 3.107 1.00 0.00 C ATOM 269 N1 ADE 9-6.275-9. 807 2.493 1.00 0.00 N ATOM 270 C6 ADE 9-6. 126-8. 476 2.604 1.00 0. 00 C ATOM 271 N6 ADE 9-5.112-7. 875 1.983 1.00 0.00 N ATOM 272 C5 ADE 9-7. 063-7. 787 3.379 1. 00 0.00 C ATOM 273 N7 ADE 9-7.213-6. 437 3.702 1.00 0.00 N ATOM 274 C8 ADE 9-8.268-6. 465 4. 444 1.00 0.00 C ATOM 275 C2'ADE 9-9.897-7. 575 6.903 1.00 0.00 C ATOM 276 02'ADE 9--9. 336-8.626 7.698 1.00 0.00 0 ATOM 277 C3'ADE 9-11.333-7. 283 7.289 1.00 0. 00 C ATOM 278 03'ADE 9-12.002-8. 542 7.490 1.00 0.00 0 ATOM 279 1H5'ADE 9-12.042-4. 679 5.121 1. 00 0.00 H ATOM 280 2H5'ADE 9-12.080-4. 666 6.895 1.00 0.00 H ATOM 281 H4'ADE 9-12.938-6. 796 5.936 1.00 0.00 H ATOM 282 Hl'ADE 9-10.248-9. 064 5.389 1.00 0.00 H ATOM 283 H2 ADE 9-7.351-11. 501 2.966 1.00 0.00 H ATOM 284 1H6 ADE 9-4.994-6. 874 2.059 1.00 0.00 H ATOM 285 2H6 ADE 9-4.461-8. 419 1.435 1.00 0.00 H ATOM 286 H8 ADE 9-8.677-5. 556 4.878 1.00 0.00 H ATOM 287 H2'ADE 9-9.299-6. 664 6.973 1.00 0. 00 H ATOM 288 H02'ADE 9-9.399-8. 354 8.616 1.00 0.00 H ATOM 289 H3'ADE 9-11.402-6. 629 8.159 1.00 0.00 H ATOM 290 P URI 10-13. 606-8.681 7.381 1.00 0.00 P ATOM 291 01P URI 10-14. 221-7.506 8.037 1.00 0.00 0 ATOM 292 02P URI 10-13.983-10. 047 7.808 1.00 0.00 0 ATOM 293 05'URI 10-13.851-8. 560 5.793 1.00 0.00 0 ATOM 294 C5'URI 10-14. 949-9. 219 5.156 1.00 0. 00 C ATOM 295 C4'URI 10-14.460-10. 208 4.100 1. 00 0. 00 C ATOM 296 04'URI 10-13. 754-11. 308 4.697 1.00 0.00 0 ATOM 297 C1'URI 10-14.516-12. 519 4.541 1. 00 0.00 C ATOM 298 N1 URI 10-14.526-13. 314 5.790 1.00 0.00 N

ATOM 299 C6 URI 10-14.052-12. 790 6.962 1.00 0.00 C ATOM 300 C2 URI 10-15.041-14. 599 5.731 1.00 0.00 C ATOM 301 02 URI 10-15.466-15. 092 4.687 1.00 0.00 O ATOM 302 N3 URI 10-15.047-15. 305 6.920 1.00 0.00 N ATOM 303 C4 URI 10-14.590-14. 849 8.144 1.00 0.00 C ATOM 304 04 URI 10-14.647-15. 567 9.140 1.00 0.00 0 ATOM 305 C5 URI 10-14.069-13. 502 8.112 1.00 0.00 C ATOM 306 C2'URI 10-15.921-12. 070 4.164 1.00 0.00 C ATOM 307 02'URI 10-16.611-13. 063 3.396 1.00 0.00 O ATOM 308 C3'URI 10-15.624-10. 833 3.342 1.00 0.00 C ATOM 309 03'URI 10-15.151-11. 248 2.053 1.00 0.00 0 ATOM 310 1H5'URI 10-15.581-8. 471 4.676 1.00 0.00 H ATOM 311 2H5'URI 10-15.536-9. 752 5.904 1.00 0.00 H ATOM 312 H4'URI 10-13.802-9. 697 3.401 1.00 0. 00 H ATOM 313 Hl'URI 10-14.094-13. 115 3.731 1. 00 0.00 H ATOM 314 H6 URI 10-13.645-11. 779 6.969 1.00 0.00 H ATOM 315 H3 URI 10-15.421-16. 243 6.892 1.00 0.00 H ATOM 316 H5 URI 10-13.687-13. 051 9.027 1.00 0.00 H ATOM 317 H2'URI 10-16.485-11. 799 5.062 1.00 0.00 H ATOM 318 H02'URI 10-16.061-13. 266 2.635 1.00 0.00 H ATOM 319 H3'URI 10-16.481-10. 163 3.275 1.00 0.00 H ATOM 320 P GUA 11-15. 043-10.204 0.829 1.00 0. 0Q P ATOM 321 OlP GUA 11-16. 318-9. 455 0.744 1.00 0. 00 0 ATOM 322 02P GUA 11-14. 538-10.933-0. 355 1.00 0.00 0 ATOM 323 05'GUA 11-13. 890-9.189 1.321 1.00 0.00 0 ATOM 324 C5'GUA 11-14. 181-7.805 1.549 1.00 0.00 C ATOM 325 C4'GUA 11-12. 920-6.942 1.487 1.00 0.00 C ATOM 326 04'GUA 11-11.941-7. 364 2.451 1.00 0.00 0 ATOM 327 Cl'GUA 11-10. 672-7.537 1.795 1.00 0.00 C ATOM 328 N9 GUA 11-10.405-8. 961 1.532 1.00 0.00 N ATOM 329 C4 GUA 11-9. 335-9.483 0.846 1.00 0.00 C ATOM 330 N3 GUA 11-8. 321-8. 773 0.304 1.00 0.00 N ATOM 331 C2 GUA 11-7.427-9. 555-0.302 1.00 0.00 C ATOM 332 N2 GUA 11-6. 355-9. 015-0.882 1.00 0.00 N ATOM 333 N1 GUA 11-7.532-10. 929-0.366 1.00 0.00 N ATOM 334 C6 GUA 11-8.562-11. 681 0.183 1.00 0.00 C ATOM 335 06 GUA 11-8.562-12. 905 0. 070 1.00 0.00 O ATOM 336 C5 GUA 11-9.517-10. 857 0.831 1.00 0.00 C ATOM 337 N7 GUA 11-10.692-11. 204 1.503 1.00 0.00 N ATOM 338 C8 GUA 11-11.132-10. 049 1.871 1.00 0.00 C ATOM 339 C2'GUA 11-10. 793-6.759 0.497 1.00 0.00 C ATOM 340 02'GUA 11-10.585-5. 355 0.698 1.00 0.00 0 ATOM 341 C3'GUA 11-12. 229-7.068 0.135 1.00 0.00 C ATOM 342 03'GUA 11-12.720-6. 044-0.732 1.00 0.00 0 ATOM 343 1H5'GUA 11-14.638-7. 695 2.532 1.00 0.00 H ATOM 344 2H5'GUA 11-14. 884-7.460 0.790 1.00 0.00 H ATOM 345 H4'GUA 11-13. 180-5.901 1.670 1.00 0.00 H ATOM 346 Hl'GUA 11-9.873-7. 120 2.409 1.00 0.00 H ATOM 347 1H2 GUA 11-5. 678-9.607-1. 341 1.00 0.00 H ATOM 348 2H2 GUA 11-6. 221-8.014-0. 862 1.00 0.00 H ATOM 349 H1 GUA 11-6.814-11. 449-0.848 1.00 0.00 H ATOM 350 H8 GUA 11-12.057-9. 949 2.432 1.00 0.00 H ATOM 351 H2'GUA 11-10.108-7. 159-0.256 1.00 0.00 H ATOM 352 H02'GUA 11-10.919-4. 904-0. 080 1.00 0.00 H ATOM 353 H3'GUA 11-12.336-8. 068-0.289 1.00 0.00 H ATOM 354 P CYT 12-13.087-6. 386-2.261 1.00 0.00 P ATOM 355 01P CYT 12-13.611-5. 158-2.899 1.00 0.00 O ATOM 356 02P CYT 12-13. 892-7. 628-2. 278 1.00 0.00 0 ATOM 357 05'CYT 12-11.645-6. 713-2.901 1. 00 0. 00 O ATOM 358 C5'CYT 12-10. 715-5.661-3. 173 1.00 0.00 C

ATOM 359 C4'CYT 12-9.374-6. 204-3.661 1.00 0.00 C ATOM 360 04'CYT 12-8.762-7. 064-2.690 1. 00 0.00 0 ATOM 361 Cl'CYT 12-8.193-8. 210-3. 355 1.00 0.00 C ATOM 362 N1 CYT 12-8.926-9. 451-3. 012 1.00 0.00 N ATOM 363 C6 CYT 12-10.145-9. 405-2.392 1.00 0.00 C ATOM 364 C2 CYT 12-8.322-10. 662-3.330 1.00 0.00 C ATOM 365 02 CYT 12-7.231-10. 682-3.897 1.00 0.00 O ATOM 366 N3 CYT 12-8.973-11. 811-3.004 1. 00 0.00 N ATOM 367 C4 CYT 12-10.165-11. 780-2.395 1.00 0.00 C ATOM 368 N4 CYT 12-10. 763-12.925-2. 075 1.00 0.00 N ATOM 369 C5 CYT 12-10. 794-10. 540-2.070 1.00 0.00 C ATOM 370 C2'CYT 12-8. 283-7.909-4. 847 1.00 0.00 C ATOM 371 02'CYT 12-7.140-7. 179-5. 306 1.00 0.00 0 ATOM 372 C3'CYT 12-9.542-7. 071-4.898 1.00 0.00 C ATOM 373 03'CYT 12-9.496-6. 231-6.055 1.00 0.00 O ATOM 374 1H5'CYT 12-10.553-5. 083-2.263 1.00 0.00 H ATOM 375 2H5'CYT 12-11.133-5. 008-3.940 1.00 0.00 H ATOM 376 H4'CYT 12-8.702-5. 377-3.883 1.00 0.00 H ATOM 377 Hl'CYT 12-7. 145-8. 314-3.068 1.00 0.00 H ATOM 378 H6 CYT 12-10.593-8. 442-2.149 1.00 0.00 H ATOM 379 1H4 CYT 12-11.658-12. 914-1.607 1.00 0.00 H ATOM 380 2H4 CYT 12-10.317-13. 805-2.293 1.00 0.00 H ATOM 381 H5 CYT 12-11.769-10. 514-1.582 1.00 0.00 H ATOM 382 H2'CYT 12-8.415-8. 834-5.413 1.00 0.00 H ATOM 383 H02'CYT 12-7.050-6. 407-4.743 1.00 0.00 H ATOM 384 H3'CYT 12-10.442-7. 686-4.857 1.00 0.00 H ATOM 385 P URI 13-10.213-6. 688-7.422 1.00 0.00 P ATOM 386 01P URI 13-10.080-5. 589-8.404 1.00 0.00 0 ATOM 387 02P URI 13-11. 552-7.223-7. 088 1.00 0.00 0 ATOM 388 05'URI 13-9.288-7. 913-7.903 1.00 0.00 0 ATOM 389 C5'URI 13-7.968-7. 675-8.398 1.00 0.00 C ATOM 390 C4'URI 13-7.193-8. 976-8.575 1.00 0.00 C ATOM 391 04'URI 13-7.045-9. 680-7.337 1.00 0.00 0 ATOM 392 C1'URI 13-7.181-11. 096-7.573 1.00 0.00 C ATOM 393 N1 URI 13-8.363-11. 651-6.873 1.00 0.00 N ATOM 394 C6 URI 13-9.434-10. 859-6.544 1.00 0. 00 C ATOM 395 C2 URI 13-8.340-12. 999-6.557 1.00 0. 00 C ATOM 396 02 URI 13-7.393-13. 726-6.851 1.00 0.00 0 ATOM 397 N3 URI 13-9. 449-13. 487-5.894 1.00 0.00 N ATOM 398 C4 URI 13-10. 565-12. 760-5.523 1.00 0.00 C ATOM 399 04 URI 13-11.491-13. 299-4.921 1.00 0.00 0 ATOM 400 C5 URI 13-10.509-11. 364-5.893 1.00 0.00 C ATOM 401 C2'URI 13-7.310-11. 262-9.086 1.00 0.00 C ATOM 402 02'URI 13-6.031-11. 445-9.705 1.00 0.00 0 ATOM 403 C3'URI 13-7.936-9. 941-9.479 1.00 0.00 C ATOM 404 03'URI 13-7. 597-9. 654-10. 839 1.00 0.00 O ATOM 405 1H5'URI 13-7.432-7. 035-7.696 1.00 0. 00 H ATOM 406 2H5'URI 13-8.036-7. 168-9.361 1.00 0.00 H ATOM 407 H4'URI 13-6.209-8. 766-8.991 1.00 0.00 H ATOM 408 Hl'URI 13-6.282-11. 607-7.229 1.00 0.00 H ATOM 409 H6 URI 13-9.422-9. 802-6.814 1.00 0.00 H ATOM 410 H3 URI 13-9.445-14. 469-5.664 1.00 0.00 H ATOM 411 H5 URI 13-11.345-10. 709-5.647 1.00 0.00 H ATOM 412 H2'URI 13-7.984-12. 089-9.320 1.00 0. 00 H ATOM 413 H02'URI 13-6.137-11. 254-10.640 1.00 0.00 H ATOM 414 H3'URI 13-9.012-9. 928-9.299 1.00 0.00 H ATOM 415 P CYT 14-8.564-10. 128-12.036 1. 00 0.00 P ATOM 416 O1P CYT 14-8.036-9. 577-13.304 1.00 0. 00 0 ATOM 417 02P CYT 14-9.964-9. 854-11.638 1.00 0. 00 O ATOM 418 05'CYT 14-8.349-11. 724-12.047 1.00 0. 00 0

ATOM 419 C5'CYT 14-7. 257-12.309-12. 762 1.00 0.00 C ATOM 420 C4'CYT 14-7.316-13. 833-12.728 1.00 0.00 C ATOM 421 04'CYT 14-7.229-14. 337-11.392 1.00 0. 00 0 ATOM 422 C1'CYT 14-8.110-15. 469-11.246 1.00 0.00 C ATOM 423 N1 CYT 14-9.167-15. 206-10.245 1.00 0.00 N ATOM 424 C6 CYT 14-9.631-13. 941-10.027 1.00 0.00 C ATOM 425 C2 CYT 14-9.672-16. 294-9.544 1.00 0.00 C ATOM 426 02 CYT 14-9. 241-17. 425-9.760 1.00 0.00 0 ATOM 427 N3 CYT 14-10.650-16. 070-8.626 1.00 0.00 N ATOM 428 C4 CYT 14-11. 116-14. 835-8.403 1.00 0.00 C ATOM 429 N4 CYT 14-12. 077-14.653-7. 500 1.00 0.00 N ATOM 430 C5 CYT 14-10.599-13. 713-9.122 1.00 0.00 C ATOM 431 C2'CYT 14-8.717-15. 721-12.624 1.00 0.00 C ATOM 432 02'CYT 14-7.954-16. 678-13. 368 1.00 0.00 0 ATOM 433 C3'CYT 14-8.647-14. 342-13.248 1.00 0.00 C ATOM 434 03'CYT 14-8. 561-14. 482-14.669 1.00 0.00 0 ATOM 435 1H5'CYT 14-6.319-11. 979-12.316 1.00 0.00 H ATOM 436 2H5'CYT 14-7.293-11. 975-13.800 1.00 0.00 H ATOM 437 H4'CYT 14-6. 505-14. 248-13.325 1.00 0.00 H ATOM 438 H1'CYT 14-7. 531-16. 341-10.942 1.00 0.00 H ATOM 439 H6 CYT 14-9. 215-13. 107-10.593 1.00 0.00 H ATOM 440 1H4 CYT 14-12.436-13. 726-7.324 1.00 0.00 H ATOM 441 2H4 CYT 14-12. 449-15. 445-6.994 1.00 0.00 H ATOM 442 H5 CYT 14-10.978-12. 708-8. 947 1.00 0.00 H ATOM 443 H2'CYT 14-9.758-16. 039-12.523 1. 00 0.00 H ATOM 444 H02'CYT 14-7.053-16. 351-13.414 1.00 0.00 H ATOM 445 H3'CYT 14-9. 480-13. 709-12.937 1. 00 0.00 H ATOM 446 P URI 15-9. 888-14. 420-15.578 1. 00 0.00 P ATOM 447 01P URI 15-10. 626-13. 183-15.237 1.00 0.00 0 ATOM 448 02P URI 15-9.503-14. 686-16.981 1.00 0.00 0 ATOM 449 05'URI 15-10.739-15. 677-15.040 1.00 0. 00 0 ATOM 450 C5'URI 15-10. 342-17. 015-15.353 1.00 0.00 C ATOM 451 C4'URI 15-11.115-18. 038-14.526 1.00 0.00 C ATOM 452 04'URI 15-10.874-17. 878-13.121 1.00 0.00 0 ATOM 453 C1'URI 15-12.120-17. 982-12.404 1.00 0.00 C ATOM 454 N1 URI 15-12.533-16. 673-11.851 1.00 0. 00 N ATOM 455 C6 URI 15-12.289-15. 512-12.534 1.00 0. 00 C ATOM 456 C2 URI 15-13.184-16. 668-10.629 1.00 0.00 C ATOM 457 02 URI 15-13.408-17. 699-10.000 1.00 0.00 0 ATOM 458 N3 URI 15-13.569-15. 429-10.151 1.00 0.00 N ATOM 459 C4 URI 15-13.362-14. 212-10.777 1.00 0.00 C ATOM 460 04 URI 15-13.746-13. 168-10.257 1.00 0.00 0 ATOM 461 C5 URI 15-12.676-14. 312-12.045 1.00 0. 00 C ATOM 462 C2'URI 15-13.136-18. 493-13.418 1.00 0. 00 C ATOM 463 02'URI 15-13.129-19. 924-13.499 1.00 0.00 0 ATOM 464 C3'URI 15-12. 616-17.859-14. 690 1. 00 0.00 C ATOM 465 03'URI 15-13.054-18. 636-15.808 1.00 0. 00 0 ATOM 466 1H5'URI 15-9.277-17. 127-15.153 1.00 0. 00 H ATOM 467 2H5'URI 15-10.527-17. 201-16.412 1.00 0.00 H ATOM 468 H4'URI 15-10.831-19. 045-14.829 1. 00 0. 00 H ATOM 469 H1'URI 15-12.015-18. 706-11.595 1.00 0.00 H ATOM 470 H6 URI 15-11.769-15. 554-13.490 1.00 0.00 H ATOM 471 H3 URI 15-14.046-15. 410-9.262 1.00 0. 00 H ATOM 472 H5 URI 15-12. 472-13.409-12. 619 1. 00 0. 00 H ATOM 473 H2'URI 15-14.134-18. 114-13.180 1.00 0.00 H ATOM 474 H02'URI 15-12. 217-20. 198-13.621 1.00 0.00 H ATOM 475 H3'URI 15-12. 899-16.807-14. 768 1.00 0.00 H ATOM 476 P URI 16-14.500-18. 376-16.463 1.00 0. 00 P ATOM 477 O1P URI 16-14.658-19. 291-17.615 1.00 0. 00 0 ATOM 478 02P URI 16-14. 670-16. 917-16.649 1.00 0. 00 0

ATOM 479 05'URI 16-15.503-18. 856-15.296 1.00 0.00 0 ATOM 480 C5'URI 16-16.921-18. 806-15.486 1.00 0.00 C ATOM 481 C4'URI 16-17. 548-20. 189-15. 364 1. 00 0.00 C ATOM 482 04'URI 16-16.883-21. 137-16. 212 1.00 0.00 0 ATOM 483 C1'URI 16-16.452-22. 260-15.437 1.00 0.00 C ATOM 484 N1 URI 16-15.176-22. 806-15.951 1.00 0.00 N ATOM 485 C6 URI 16-14.053-22. 024-16.023 1.00 0.00 C ATOM 486 C2 URI 16-15.160-24. 130-16.354 1.00 0.00 C ATOM 487 02 URI 16-16.158-24. 847-16.295 1.00 0.00 0 ATOM 488 N3 URI 16-13.952-24. 606-16.829 1. 00 0. 00 N ATOM 489 C4 URI 16-12. 775-23.885-16. 935 1. 00 0.00 C ATOM 490 04 URI 16-11.755-24. 413-17.374 1.00 0.00 O ATOM 491 C5 URI 16-12. 882-22.514-16. 493 1.00 0.00 C ATOM 492 C2'URI 16-16. 294-21.734-14. 021 1.00 0.00 C ATOM 493 02'URI 16-16.444-22. 778-13. 051 1.00 0.00 0 ATOM 494 C3'URI 16-17.424-20. 722-13. 936 1.00 0.00 C ATOM 495 03'URI 16-18.637-21. 408-13. 612 1.00 0.00 0 ATOM 496 1H5'URI 16-17.136-18. 400-16.469 1.00 0.00 H ATOM 497 2H5'URI 16-17.360-18. 153-14.735 1.00 0.00 H ATOM 498 H4'URI 16-18.599-20. 136-15. 642 1.00 0.00 H ATOM 499 Hl'URI 16-17.220-23. 034-15.456 1.00 0.00 H ATOM 500 H6 URI 16-14.103-20. 986-15.696 1.00 0.00 H ATOM 501 H3 URI 16-13. 926-25.570-17. 126 1.00 0.00 H ATOM 502 H5 URI 16-12.007-21. 865-16.538 1.00 0.00 H ATOM 503 H2'URI 16-15.331-21. 228-13.910 1.00 0.00 H ATOM 504 H02'URI 16-16. 462-22.363-12. 185 1.00 0.00 H ATOM 505 H3'URI 16-17.204-19. 927-13.224 1.00 0.00 H ATOM 506 P CYT 17-19.962-20. 572-13.235 1.00 0.00 P ATOM 507 O1P CYT 17-20. 379-19.798-14. 427 1.00 0.00 0 ATOM 508 02P CYT 17-20.919-21. 490-12.580 1.00 0.00 0 ATOM 509 05'CYT 17-19. 414-19. 538-12. 128 1.00 0.00 O ATOM 510 C5'CYT 17-18.942-20. 019-10. 868 1.00 0. 00 C ATOM 511 C4'CYT 17-18. 417-18. 895-9.983 1. 00 0. 00 C ATOM 512 04'CYT 17-17. 300-18. 227-10.588 1.00 0.00 0 ATOM 513 C1'CYT 17-17.530-16. 818-10.556 1.00 0.00 C ATOM 514 Nl CYT 17-16.853-16. 134-11.674 1.00 0.00 N ATOM 515 C6 CYT 17-16. 549-16. 808-12.814 1.00 0.00 C ATOM 516 C2 CYT 17-16.535-14. 791-11.518 1.00 0.00 C ATOM 517 02 CYT 17-16.817-14. 203-10.475 1.00 0.00 0 ATOM 518 N3 CYT 17-15.905-14. 156-12.544 1.00 0.00 N ATOM 519 C4 CYT 17-15.600-14. 809-13.672 1.00 0.00 C ATOM 520 N4 CYT 17-14. 979-14.161-14. 658 1.00 0.00 N ATOM 521 C5 CYT 17-15.928-16. 191-13.832 1.00 0.00 C ATOM 522 C2'CYT 17-19.037-16. 679-10.646 1.00 0.00 C ATOM 523 02'CYT 17-19.486-15. 413-10.148 1.00 0.00 0 ATOM 524 C3'CYT 17-19.487-17. 829-9.757 1.00 0.00 C ATOM 525 03'CYT 17-19.412-17. 406-8.391 1.00 0.00 0 ATOM 526 1H5'CYT 17-18.143-20. 734-11.038 1.00 0.00 H ATOM 527 2H5'CYT 17-19. 759-20. 518-10.355 1.00 0.00 H ATOM 528 H4'CYT 17-18.111-19. 306-9.023 1.00 0.00 H ATOM 529 H1'CYT 17-17. 180-16. 413-9.613 1.00 0.00 H ATOM 530 H6 CYT 17-16.809-17. 862-12.900 1.00 0.00 H ATOM 531 1H4 CYT 17-14.743-14. 646-15.512 1. 00 0. 00 H ATOM 532 2H4 CYT 17-14. 745-13.184-14. 551 1.00 0.00 H ATOM 533 H5 CYT 17-15. 687-16.726-14. 746 1.00 0. 00 H ATOM 534 H2'CYT 17-19.371-16. 845-11.674 1.00 0.00 H ATOM 535 H02'CYT 17-20.442-15. 458-10.075 1.00 0.00 H ATOM 536 H3'CYT 17-20.479-18. 192-10.024 1.00 0.00 H ATOM 537 P GUA 18-20. 495-17. 911-7.310 1.00 0.00 P ATOM 538 01P GUA 18-20. 086-17. 413-5.977 1.00 0.00 0

ATOM 539 02P GUA 18-21.846-17. 599-7.828 1.00 0.00 0 ATOM 540 05'GUA 18-20.305-19. 511-7.333 1.00 0.00 0 ATOM 541 C5'GUA 18-19.218-20. 135-6.640 1.00 0.00 C ATOM 542 C4'GUA 18-19.251-21. 653-6.804 1.00 0.00 C ATOM 543 04'GUA 18-19.128-22. 035-8.177 1.00 0.00 0 ATOM 544 C1'GUA 18-18.329-23. 230-8.276 1.00 0.00 C ATOM 545 N9 GUA 18-17. 105-22.996-9. 071 1.00 0.00 N ATOM 546 C4 GUA 18-16.350-21. 843-9. 109 1.00 0.00 C ATOM 547 N3 GUA 18-16.598-20. 707-8.419 1.00 0.00 N ATOM 548 C2 GUA 18-15.689-19. 758-8.664 1.00 0.00 C ATOM 549 N2 GUA 18-15.790-18. 570-8.070 1.00 0.00 N ATOM 550 N1 GUA 18-14.622-19. 925-9.522 1.00 0.00 N ATOM 551 C6 GUA 18-14.344-21. 079-10.240 1.00 0.00 C ATOM 552 06 GUA 18-13.363-21. 125-10.977 1.00 0.00 0 ATOM 553 C5 GUA 18-15.306-22. 093-9.987 1. 00 0.00 C ATOM 554 N7 GUA 18-15.395-23. 389-10.501 1.00 0.00 N ATOM 555 C8 GUA 18-16.458-23. 831-9.920 1.00 0.00 C ATOM 556 C2'GUA 18-17.983-23. 638-6.844 1.00 0.00 C ATOM 557 02'GUA 18-18.922-24. 590-6.330 1.00 0.00 O ATOM 558 C3'GUA 18-18. 074-22.313-6. 110 1.00 0.00 C ATOM 559 03'GUA 18-18.429-22. 572-4. 746 1.00 0.00 O ATOM 560 1H5'GUA 18-19. 284-19.890-5. 580 1.00 0.00 H ATOM 561 2H5'GUA 18-18.277-19. 754-7.036 1.00 0.00 H ATOM 562 H4'GUA 18-20.183-22. 047-6.402 1.00 0.00 H ATOM 563 H1'GUA 18-18.919-24. 019-8.745 1.00 0.00 H ATOM 564 1H2 GUA 18-15. 103-17.853-8. 255 1.00 0.00 H ATOM 565 2H2 GUA 18-16.552-18. 386-7.433 1.00 0.00 H ATOM 566 H1 GUA 18-13.979-19. 156-9.655 1.00 0.00 H ATOM 567 H8 GUA 18-16. 822-24. 842-10.104 1.00 0.00 H ATOM 568 H2'GUA 18-16.963-24. 029-6.798 1.00 0.00 H ATOM 569 H02'GUA 18-18. 808-24.615-5. 377 1.00 0.00 H ATOM 570 H3'GUA 18-17.158-21. 730-6.206 1.00 0.00 H ATOM 571 P GUA 19-17. 582-21.927-3. 535 1.00 0.00 P ATOM 572 01P GUA 19-18.106-22. 472-2. 263 1.00 0.00 0 ATOM 573 02P GUA 19-17. 522-20.463-3. 742 1.00 0.00 0 ATOM 574 05'GUA 19-16.107-22. 530-3.773 1.00 0.00 0 ATOM 575 C5'GUA 19-15. 888-23.945-3. 794 1.00 0.00 C ATOM 576 C4'GUA 19-14.754-24. 323-4. 745 1.00 0.00 C ATOM 577 04'GUA 19-14. 944-23. 741-6.046 1.00 0.00 0 ATOM 578 C1'GUA 19-13. 720-23.115-6. 474 1.00 0.00 C ATOM 579 N9 GUA 19-13.797-21. 644-6.363 1.00 0.00 N ATOM 580 C4 GUA 19-12. 977-20. 729-6. 984 1.00 0.00 C ATOM 581 N3 GUA 19-11. 961-21. 018-7. 829 1. 00 0.00 N ATOM 582 C2 GUA 19-11.344-19. 919-8.271 1.00 0.00 C ATOM 583 N2 GUA l9-10. 316-20.025-9. 113 1.00 0.00 N ATOM 584 NI GUA 19-11. 707-18.638-7. 905 1.00 0.00 N ATOM 585 C6 GUA 19-12.744-18. 317-7.042 1.00 0.00 C ATOM 586 06 GUA 19-12. 990-17.142-6. 783 1.00 0.00 0 ATOM 587 C5 GUA 19-13.405-19. 479-6.566 1.00 0.00 C ATOM 588 N7 GUA 19-14. 486-19.596-5. 689 1. 00 0. 00 N ATOM 589 C8 GUA 19-14. 641-20.875-5. 633 1.00 0.00 C ATOM 590 C2'GUA 19-12.643-23. 666-5.555 1.00 0.00 C ATOM 591 02'GUA 19-12.165-24. 940-6.006 1.00 0.00 0 ATOM 592 C3'GUA 19-13. 417-23. 782-4.258 1.00 0.00 C ATOM 593 03'GUA 19-12.790-24. 771-3.435 1.00 0. 00 0 ATOM 594 1H5'GUA 19-16.802-24. 442-4.116 1.00 0.00 H ATOM 595 2H5'GUA 19-15.636-24. 281-2.788 1.00 0.00 H ATOM 596 H4'GUA 19-14. 700-25.407-4. 840 1.00 0.00 H ATOM 597 H1'GUA 19-13.504-23. 396-7. 505 1.00 0.00 H ATOM 598 1H2 GUA 19-10. 004-20. 937-9.416 1.00 0.00 H

ATOM 599 2H2 GUA 19-9.849-19. 194-9.447 1.00 0. 00 H ATOM 600 Hl GUA 19-11.189-17. 857-8.283 1.00 0. 00 H ATOM 601 H8 GUA 19-15. 420-21.321-5. 018 1.00 0.00 H ATOM 602 H2'GUA 19-11. 825-22. 948-5.452 1.00 0. 00 H ATOM 603 H02'GUA 19-11.693-24. 792-6.829 1.00 0.00 H ATOM 604 H3'GUA 19-13.520-22. 818-3.757 1.00 0.00 H ATOM 605 P ADE 20-11.627-24. 352-2.402 1.00 0. 00 P ATOM 606 O1P ADE 20-12.167-23. 319-1.490 1.00 0. 00 0 ATOM 607 02P ADE 20-11.035-25. 589-1.845 1.00 0.00 0 ATOM 608 05'ADE 20-10.537-23. 657-3.362 1.00 0.00 0 ATOM 609 C5'ADE 20-9.715-24. 450-4.223 1.00 0.00 C ATOM 610 C4'ADE 20-8.786-23. 585-5.070 1.00 0.00 C ATOM 611 04'ADE 20-9.511-22. 685-5.915 1.00 0.00 0 ATOM 612 C1'ADE 20-8. 801-21. 430-5.993 1.00 0.00 C ATOM 613 N9 ADE 20-9.598-20. 323-5.427 1. 00 0.00 N ATOM 614 C4 ADE 20-9.398-18. 976-5.636 1.00 0.00 C ATOM 615 N3 ADE 20-8.432-18. 419-6.393 1.00 0.00 N ATOM 616 C2 ADE 20-8. 516-17. 093-6.386 1.00 0.00 C ATOM 617 Nl ADE 20-9. 412-16. 345-5.739 1.00 0.00 N ATOM 618 C6 ADE 20-10. 368-16. 924-4. 991 1.00 0.00 C ATOM 619 N6 ADE 20-11.262-16. 159-4.365 1.00 0.00 N ATOM 620 C5 ADE 20-10.375-18. 321-4.923 1.00 0.00 C ATOM 621 N7 ADE 20-11. 199-19. 233-4.256 1.00 0.00 N ATOM 622 C8 ADE 20-10.675-20. 360-4.605 1.00 0.00 C ATOM 623 C2'ADE 20-7. 509-21. 627-5.206 1.00 0. 00 C ATOM 624 02'ADE 20-6.446-22. 090-6. 048 1.00 0. 00 0 ATOM 625 C3'ADE 20-7.930-22. 682-4.205 1.00 0.00 C ATOM 626 03'ADE 20-6.773-23. 407-3.778 1.00 0.00 0 ATOM 627 1H5'ADE 20-10.353-25. 039-4. 884 1.00 0.00 H ATOM 628 2H5'ADE 20-9.114-25. 126-3.615 1.00 0.00 H ATOM 629 H4'ADE 20-8.148-24. 220-5.683 1.00 0.00 H ATOM 630 H1'ADE 20-8. 563-21. 213-7.035 1.00 0.00 H ATOM 631 H2 ADE 20-7. 770-16. 557-6. 972 1.00 0.00 H ATOM 632 1H6 ADE 20-11.989-16. 586-3.809 1.00 0.00 H ATOM 633 2H6 ADE 20-11.218-15. 154-4.453 1.00 0.00 H ATOM 634 H8 ADE 20-11. 078-21. 306-4.245 1.00 0.00 H ATOM 635 H2'ADE 20-7.232-20. 702-4.694 1.00 0. 00 H ATOM 636 HO2'ADE 20-6. 751-22. 892-6.478 1.00 0.00 H ATOM 637 H3'ADE 20-8.492-22. 255-3.373 1.00 0.00 H ATOM 638 P GUA 21-5.867-22. 850-2.569 1.00 0. 00 P ATOM 639 01P GUA 21-4. 799-23. 838-2.297 1.00 0.00 0 ATOM 640 02P GUA 21-6.767-22. 417-1. 476 1. 00 0.00 0 ATOM 641 05'GUA 21-5.192-21. 539-3.216 1. 00 0.00 0 ATOM 642 C5'GUA 21-4.156-21. 664-4.193 1.00 0.00 C ATOM 643 C4'GUA 21-3.601-20. 304-4.608 1.00 0.00 C ATOM 644 04'GUA 21-4.587-19. 496-5.259 1.00 0.00 0 ATOM 645 C1'GUA 21-4.412-18. 120-4.863 1.00 0.00 C ATOM 646 N9 GUA 21-5.596-17. 620-4.136 1.00 0. 00 N ATOM 647 C4 GUA 21-5.999-16. 307-4.023 1.00 0.00 C ATOM 648 N3 GUA 21-5. 343-15.231-4. 514 1.00 0.00 N ATOM 649 C2 GUA 21-5.980-14. 086-4.247 1. 00 0. 00 C ATOM 650 N2 GUA 21-5.459-12. 925-4.643 1.00 0.00 N ATOM 651 Nl GUA 21-7.172-14. 018-3. 553 1.00 0. 00 N ATOM 652 C6 GUA 21-7. 863-15. 107-3. 041 1. 00-0. 00 C ATOM 653 06 GUA 21-8.928-14. 940-2.452 1.00 0.00 0 ATOM 654 C5 GUA 21-7.191-16. 327-3.316 1.00 0.00 C ATOM 655 N7 GUA 21-7. 541-17. 637-2.977 1.00 0. 00 N ATOM 656 C8 GUA 21-6.565-18. 309-3.487 1.00 0.00 C ATOM 657 C2'GUA 21-3.166-18. 090-3. 981 1. 00 0. 00 C ATOM 658 02'GUA 21-1. 984-17. 847-4.753 1.00 0. 00 O

ATOM 659 C3'GUA 21-3.177-19. 489-3.402 1.00 0. 00 C ATOM 660 03'GUA 21-1.842-19. 860-3.044 1.00 0.00 0 ATOM 661 1H5'GUA 21-4. 554-22.169-5. 074 1.00 0.00 H ATOM 662 2H5'GUA 21-3.347-22. 264-3. 776 1.00 0.00 H ATOM 663 H4'GUA 21-2.750-20. 442-5.274 1.00 0.00 H ATOM 664 H1'GUA 21-4.244-17. 506-5.748 1.00 0.00 H ATOM 665 1H2 GUA 21-4.583-12. 911-5.146 1. 00 0.00 H ATOM 666 2H2 GUA 21-5.939-12. 060-4.439 1.00 0.00 H ATOM 667 Hl GUA 21-7.596-13. 114-3.399 1.00 0.00 H ATOM 668 H8 GUA 21-6.511-19. 391-3.381 1.00 0.00 H ATOM 669 H2'GUA 21-3. 282-17.347-3. 191 1.00 0.00 H ATOM 670 H02'GUA 21-1.851-16. 896-4.780 1.00 0.00 H ATOM 671 H3'GUA 21-3.880-19. 584-2.572 1.00 0.00 H ATOM 672 P ADE 22-1.234-19. 454-1.608 1. 00 0.00 P ATOM 673 01P ADE 22-0.001-20. 243-1. 388 1. 00 0.00 0 ATOM 674 02P ADE 22-2.326-19. 499-0.610 1.00 0.00 0 ATOM 675 05'ADE 22-0. 816-17. 915-1. 828 1. 00 0.00 0 ATOM 676 C5'ADE 22 0.205-17. 571-2.769 1.00 0.00 C ATOM 677 C4'ADE 22 0.180-16. 085-3.113 1.00 0.00 C ATOM 678 04'ADE 22-1.108-15. 673-3.592 1.00 0.00 0 ATOM 679 C1'ADE 22-1. 426-14. 378-3.045 1. 00 0.00 C ATOM 680 N9 ADE 22-2.551-14. 450-2.092 1. 00 0.00 N ATOM 681 C4 ADE 22-3. 279-13. 387-1. 612 1. 00 0.00 C ATOM 682 N3 ADE 22-3.132-12. 094-1. 964 1. 00 0.00 N ATOM 683 C2 ADE 22-3.990-11. 316-1.314 1.00 0.00 C ATOM 684 N1 ADE 22-4.901-11. 697-0.418 1.00 0.00 N ATOM 685 C6 ADE 22-5.028-12. 993-0.083 1.00 0.00 C ATOM 686 N6 ADE 22-5. 939-13. 350 0.821 1. 00 0.00 N ATOM 687 C5 ADE 22-4.176-13. 906-0.708 1.00 0.00 C ATOM 688 N7 ADE 22-4.035-15. 292-0.605 1.00 0.00 N ATOM 689 C8 ADE 22-3.077-15. 518-1.438 1.00 0. 00 C ATOM 690 C2'ADE 22-0.162-13. 904-2.340 1.00 0.00 C ATOM 691 02'ADE 22 0.717-13. 215-3.238 1. 00 0.00 O ATOM 692 C3'ADE 22 0.420-15. 225-1. 886 1. 00 0.00 C ATOM 693 03'ADE 22 1.828-15. 069-1. 690 1. 00 0. 00 0 ATOM 694 1H5'ADE 22 0.056-18. 148-3.682 1. 00 0.00 H ATOM 695 2H5'ADE 22 1.178-17. 821-2.345 1.00 0.00 H ATOM 696 H4'ADE 22 0. 933-15. 868-3. 868 1. 00 0.00 H ATOM 697 Hl'ADE 22-1.674-13. 690-3.854 1. 00 0.00 H ATOM 698 H2 ADE 22-3. 949-10. 250-1.541 1.00 0.00 H ATOM 699 1H6 ADE 22-6.036-14. 321 1. 083 1.00 0.00 H ATOM 700 2H6 ADE 22-6.531-12. 651 1.244 1. 00 0.00 H ATOM 701 H8 ADE 22-2.706-16. 528-1. 609 1. 00 0.00 H ATOM 702 H2'ADE 22-0.417-13. 280-1.478 1.00 0.00 H ATOM 703 H02'ADE 22 0.320-12. 362-3.428 1.00 0.00 H ATOM 704 H3'ADE 22-0.090-15. 614-1.003 1.00 0.00 H ATOM 705 P CYT 23 2.394-14. 532-0.281 1.00 0.00 P ATOM 706 01P CYT 23 3.871-14. 481-0.363 1.00 0.00 0 ATOM 707 02P CYT 23 1.742-15. 299 0.804 1. 00 0. 00 O ATOM 708 05'CYT 23 1. 838-13.021-0. 233 1. 00 0.00 0 ATOM 709 C5'CYT 23 2.385-12. 020-1.094 1. 00 0.00 C ATOM 710 C4'CYT 23 1.766-10. 649-0.834 1.00 0.00 C ATOM 711 04'CYT 23 0. 357-10-641-1. 067 1.00 0.00 0 ATOM 712 C1'CYT 23-0. 261-9. 696-0. 169 1.00 0.00 C ATOM 713 N1 CYT 23-1. 319-10. 333 0.647 1.00 0.00 N ATOM 714 C6 CYT 23-1. 216-11. 636 1.045 1. 00 0.00 C ATOM 715 C2 CYT 23-2.409-9. 550 1.007 1. 00 0. 00 C ATOM 716 02 CYT 23-2.483-8. 380 0.635 1.00 0.00 O ATOM 717 N3 CYT 23-3.380-10. 112 1.775 1.00 0.00 N ATOM 718 C4 CYT 23-3. 293-11. 386 2.174 1.00 0.00 C

ATOM 719 N4 CYT 23-4.263-11. 901 2.928 1.00 0.00 N ATOM 720 C5 CYT 23-2.175-12. 198 1.805 1.00 0.00 C ATOM 721 C2'CYT 23 0.858-9. 149 0.723 1.00 0.00 C ATOM 722 02'CYT 23 1.355-7. 899 0.231 1.00 0.00 0 ATOM 723 C3'CYT 23 1.901-10. 246 0.619 1.00 0.00 C ATOM 724 03'CYT 23 3.199-9. 680 0.819 1.00 0.00 0 ATOM 725 1H5'CYT 23 2.201-12. 302-2.131 1.00 0.00 H ATOM 726 2H5'CYT 23 3.461-11. 960-0.928 1.00 0.00 H ATOM 727 H4'CYT 23 2.241-9. 903-1.469 1. 00 0.00 H ATOM 728 Hl'CYT 23-0.692-8. 878-0.747 1. 00 0.00 H ATOM 729 H6 CYT 23-0. 351-12.227 0.743 1.00 0.00 H ATOM 730 1H4 CYT 23-4.207-12. 861 3.237 1.00 0.00 H ATOM 731 2H4 CYT 23-5.054-11. 331 3.191 1.00 0.00 H ATOM 732 H5 CYT 23-2.102-13. 235 2.130 1.00 0. 00 H ATOM 733 H2'CYT 23 0. 508-9. 055 1.754 1.00 0.00 H ATOM 734 H02'CYT 23 1.652-8. 044-0.670 1.00 0.00 H ATOM 735 H3'CYT 23 1.692-11. 075 1.297 1.00 0.00 H ATOM 736 P GUA 24 3.766-9. 435 2.307 1.00 0.00 P ATOM 737 01P GUA 24 3. 110-10. 399 3.220 1.00 0.00 0 ATOM 738 02P GUA 24 5.243-9. 374 2.236 1.00 0.00 0 ATOM 739 05'GUA 24 3.216-7. 963 2.652 1.00 0.00 0 ATOM 740 C5'GUA 24 3.576-6. 845 1.836 1.00 0.00 C ATOM 741 C4'GUA 24 2.898-5. 562 2.308 1.00 0.00 C ATOM 742 04'GUA 24 1.470-5. 702 2.344 1.00 0.00 0 ATOM 743 C1'GUA 24 0.965-5. 138 3.568 1.00 0.00 C ATOM 744 N9 GUA 24 0.494-6. 185 4.493 1.00 0.00 N ATOM 745 C4 GUA 24-0.259-5. 987 5.625 1.00 0.00 C ATOM 746 N3 GUA 24-0.700-4. 793 6.078 1.00 0.00 N ATOM 747 C2 GUA 24-1.408-4. 910 7.201 1.00 0.00 C ATOM 748 N2 GUA 24-1.920-3. 825 7.780 1.00 0.00 N ATOM 749 Nl GUA 24-1.658-6. 116 7.826 1.00 0.00 N ATOM 750 C6 GUA 24-1.215-7. 355 7.381 1.00 0.00 C ATOM 751 06 GUA 24-1.490-8. 372 8.016 1.00 0.00 0 ATOM 752 C5 GUA 24-0. 461-7. 239 6.184 1.00 0.00 C ATOM 753 N7 GUA 24 0.160-8. 227 5.412 1.00 0.00 N ATOM 754 C8 GUA 24 0.683-7. 528 4.461 1.00 0.00 C ATOM 755 C2'GUA 24 2.126-4. 363 4.171 1.00 0.00 C ATOM 756 02'GUA 24 2.207-3. 037 3.634 1.00 0.00 0 ATOM 757 C3'GUA 24 3.295-5. 219 3.735 1.00 0.00 C ATOM 758 03'GUA 24 4.477-4. 412 3.706 1.00 0.00 0 ATOM 759 1H5'GUA 24 3.277-7. 046 0.807 1.00 0. zu H ATOM 760 2H5'GUA 24 4.657-6. 710 1.872 1.00 0.00 H ATOM 761 H4'GUA 24 3.163-4. 740 1.645 1.00 0.00 H ATOM 762 Hl'GUA 24 0.146-4. 453 3.349 1.00 0.00 H ATOM 763 1H2 GUA 24-1.771-2. 915 7.366 1.00 0.00 H ATOM 764 2H2 GUA 24-2.458-3. 910 8.629 1.00 0.00 H ATOM 765 H1 GUA 24-2. 203-6. 121 8.673 1.00 0.00 H ATOM 766 H8 GUA 24 1.257-7. 999 3.663 1.00 0.00 H ATOM 767 H2'GUA 24 2.047-4. 345 5.261 1.00 0.00 H ATOM 768 H02'GUA 24 1. 507-2.521 4.040 1.00 0.00 H ATOM 769 H3'GUA 24 3.405-6. 108 4.357 1.00 0.00 H ATOM 770 P ADE 25 5.340-4. 178 5.046 1.00 0.00 P ATOM 771 01P ADE 25 6.546-3. 396 4.691 1.00 0. 00 0 ATOM 772 02P ADE 25 5.482-5. 478 5.740 1.00 0.00 0 ATOM 773 05'ADE 25 4.372-3. 240 5.927 1.00 0.00 O ATOM 774 C5'ADE 25 4.016-1. 933 5.468 1.00 0.00 C ATOM 775 C4'ADE 25 2.943-1. 294 6.345 1.00 0.00 C ATOM 776 04'ADE 25 1.771-2. 113 6.442 1.00 0.00 O ATOM 777 C1'ADE 25 1.245-2. 033 7.784 1. 00 0.00 C ATOM 778 N9 ADE 25 1.315-3. 341 8.468 1.00 0.00 N

ATOM 779 C4 ADE 25 0. 724-3. 674 9.668 1.00 0.00 C ATOM 780 N3 ADE 25-0.048-2. 874 10.429 1.00 0.00 N ATOM 781 C2 ADE 25-0.460-3. 500 11.527 1.00 0.00 C ATOM 782 N1 ADE 25-0. 184-4. 753 11.893 1.00 0.00 N ATOM 783 C6 ADE 25 0.589-5. 533 11.117 1.00 0.00 C ATOM 784 N6 ADE 25 0.857-6. 780 11.502 1.00 0.00 N ATOM 785 C5 ADE 25 1.081-4. 977 9.930 1.00 0.. 00 C ATOM 786 N7 ADE 25 1.892-5. 485 8.911 1.00 0.00 N ATOM 787 C8 ADE 25 1.972-4. 473 8.113 1.00 0.00 C ATOM 788 C2'ADE 25 2.098-0. 994 8.509 1.00 0.00 C ATOM 789 02'ADE 25 1.552 0.323 8.372 1.00 0.00 0 ATOM 790 C3'ADE 25 3.416-1. 133 7.777 1.00 0.00 C ATOM 791 03'ADE 25 4.142 0.094 7.884 1.00 0.00 0 ATOM 792 1H5'ADE 25 3.642-2. 006. 4.446 1.00 0.00 H ATOM 793 2H5'ADE 25 4.904-1. 300 5.476 1.00 0.00 H ATOM 794 H4'ADE 25 2.669-0. 321 5.939 1. 00 0.00 H ATOM 795 Hl'ADE 25 0.209-1. 694 7.749 1. 00 0.00 H ATOM 796 H2 ADE 25-1.095-2. 926 12.202 1. 00 0.00 H ATOM 797 1H6 ADE 25 1.440-7. 371 10.926 1.00 0.00 H ATOM 798 2H6 ADE 25 0.479-7. 133 12.369 1.00 0.00 H ATOM 799 H8 ADE 25 2. 545-4. 527 7.187 1. 00 0.00 H ATOM 800 H2'ADE 25 2.214-1. 267 9.561 1.00 0.00 H ATOM 801 H02'ADE 25 1.446 0.492 7. 433. 1.00 0.00 H ATOM 802 H3'ADE 25 3.987-1. 996 8.125 1.00 0.00 H ATOM 803 P CYT 26 5.120 0.355 9.136 1.00 0.00 P ATOM 804 01P CYT 26 5.907-0. 875 9.376 1. 00 0.00 0 ATOM 805 02P CYT 26 5.813 1. 646 8.923 1.00 0.00 0 ATOM 806 05'CYT 26 4.081 0.532 10.351 1.00 0.00 0 ATOM 807 C5'CYT 26 3.264 1.702 10.443 1.00 0.00 C ATOM 808 C4'CYT 26 2.361 1. 661 11.670 1.00 0.00 C ATOM 809 04'CYT 26 1.413 0.587 11.608 1.00 0.00 0 ATOM 810 C1'CYT 26 1.290-0. 015 12.914 1.00 0.00 C ATOM 811 N1 CYT 26 1. 842-1. 387 12.931 1.00 0.00 N ATOM 812 C6 CYT 26 2.897-1. 727 12.135 1.00 0.00 C ATOM 813 C2 CYT 26 1.268-2. 303 13.805 1.00 0.00 C ATOM 814 02 CYT 26 0. 315-1. 975 14.509 1.00 0.00 0 ATOM 815 N3 CYT 26 1.788-3. 560 13.853 1.00 0.00 N ATOM 816 C4 CYT 26 2.825-3. 905 13.080 1.00 0.00 C ATOM 817 N4 CYT 26 3. 309-5. 145 13.153 1.00 0.00 N ATOM 818 C5 CYT 26 3.417-2. 964 12.179 1.00 0.00 C ATOM 819 C2'CYT 26 2.074 0.891 13.859 1.00 0.00 C ATOM 820 02'CYT 26 1.264 1.963 14.357 1.00 0.00 0 ATOM 821 C3'CYT 26 3.159 1. 389 12.931 1.00 0.00 C ATOM 822 03'CYT 26 3.674 2.627 13.429 1.00 0.00 0 ATOM 823 1H5'CYT 26 2.646 1.777 9. 548 1.00 0.00 H ATOM 824 2H5'CYT 26 3.908 2.579 10.505 1.00 0.00 H ATOM 825 H4'CYT 26 1.829 2.606 11.768 1.00 0.00 H ATOM 826 H1'CYT 26 0.241-0. 035 13.212 1.00 0.00 H ATOM 827 H6 CYT 26 3.318-0. 990 11.450 1.00 0. 00 H ATOM 828 1H4 CYT 26 4.091-5. 417 12.574 1.00 0.00 H ATOM 829 2H4 CYT 26 2.893-5. 813 13.786 1.00 0.00 H ATOM 830 H5 CYT 26 4.270-3. 233 11.561 1.00 0.00 H ATOM 831 H2'CYT 26 2.505 0.305 14.676 1.00 0.00 H ATOM 832 H02'CYT 26 0. 869 2.398 13.598 1.00 0.00 H ATOM 833 H3'CYT 26 3.937 0.637 12.772 1. 00 0. 00 H ATOM 834 P CYT 27 5.188 2.721 13.969 1.00 0.00 P ATOM 835 01P CYT 27 6.061 1. 972 13.037 1.00 0.00 0 ATOM 836 02P CYT 27 5.483 4.137 14.280 1.00 0.00 0 ATOM 837 05'CYT 27 5.113 1.904 15.354 1.00 0. 00 0 ATOM 838 C5'CYT 27 4. 265 2. 354 16.414 1.00 0. 00 C

ATOM 839 C4'CYT 27 3.991 1.247 17.428 1.00 0.00 C ATOM 840 04'CYT 27 3.439 0.083 16.811 1.00 0.00 O ATOM 841 C1'CYT 27 3.878-1. 086 17. 535 1.00 0.00 C ATOM 842 N1 CYT 27 4. 574-2.052 16.653 1.00 0.00 N ATOM 843 C6 CYT 27 4.973-1. 709 15.392 1.00 0. 00 C ATOM 844 C2 CYT 27 4.814-3. 319 17.167 1.00 0.00 C ATOM 845 02 CYT 27 4.449-3. 602 18.305 1.00 0.00 0 ATOM 846 N3 CYT 27 5.461-4. 224 16. 385 1.00 0.00 N ATOM 847 C4 CYT 27 5.859-3. 904 15. 148 1.00 0.00 C ATOM 848 N4 CYT 27 6.489-4. 818 14.411 1.00 0.00 N ATOM 849 C5 CYT 27 5.616-2. 601 14.610 1.00 0.00 C ATOM 850 C2'CYT 27 4.815-0. 583 18.636 1.00 0.00 C ATOM 851 02'CYT 27 4. 122-0.423 19.880 1.00 0.00 0 ATOM 852 C3'CYT 27 5.268 0.750 18.074 1.00 0.00 C ATOM 853 03'CYT 27 5. 608 1.618 19.161 1.00 0.00 0 ATOM 854 1H5'CYT 27 3.318 2.690 15.992 1. 00 0.00 H ATOM 855 2H5'CYT 27 4.745 3.191 16.922 1.00 0.00 H ATOM 856 H4'CYT 27 3.307 1.609 18.194 1.00 0.00 H ATOM 857 H1'CYT 27 3.015-1. 571 17.991 1.00 0.00 H ATOM 858 H6 CYT 27 4.770-0. 706 15.014 1.00 0.00 H ATOM 859 1H4 CYT 27 6.793-4. 591 13.475 1.00 0.00 H ATOM 860 2H4 CYT 27 6.667-5. 737 14.791 1.00 0.00 H ATOM 861 H5 CYT 27 5. 944-2. 337 13.604 1.00 0.00 H ATOM 862 H2'CYT 27 5.667-1. 258 18.745 1.00 0.00 H ATOM 863 H02'CYT 27 3.387 0.176 19.723 1.00 0.00 H ATOM 864 H3'. CYT 27 6.079 0.636 17.353 1.00 0., 00 H ATOM 865 P GUA 28 7.043 1.497 19.886 1.00 0.00 P ATOM 866 01P GUA 28 8.054 1.158 18.860 1.00 0.00 0 ATOM 867 02P GUA 28 7.231 2.691 20.740 1.00 0.00 O ATOM 868 05'GUA 28 6.849 0.215 20.844 1.00 0.00 0 ATOM 869 C5'GUA 28 6.135 0.330 22.079 1.00 0.00 C ATOM 870 C4'GUA 28 6.302-0. 915 22.948 1.00 0.00 C ATOM 871 04'GUA 28 5.791-2. 087 22.301 1.00 0.00 0 ATOM 872 Cl'GUA 28 6.665-3. 202 22.566 1.00 0.00 C ATOM 873 N9 GUA 28 7.299-3. 690 21.324 1.00 0.00 N ATOM 874 C4 GUA 28 7.862-4. 932 21.122 1.00 0.00 C ATOM 875 N3 GUA 28 7.940-5. 926 22.035 1.00 0.00 N ATOM 876 C2 GUA 28 8.540-7. 015 21.547 1.00 0.00 C ATOM 877 N2 GUA 28 8.703-8. 088 22.320 1.00 0.00 N ATOM 878 N1 GUA 28 9.024-7. 111 20.257 1.00 0.00 N ATOM 879 C6 GUA 28 8.956-6. 105 19.302 1.00 0.00 C ATOM 880 06 GUA 28 9.418-6. 291 18.179 1.00 0.00 0 ATOM 881 C5 GUA 28 8.319-4. 943 19.813 1.00 0.00 C ATOM 882 N7 GUA 28 8.051-3. 721 19.188 1.00 0.00 N ATOM 883 C8 GUA 28 7.465-3. 065 20.132 1.00 0.00 C ATOM 884 C2'GUA 28 7.712-2. 694 23.554 1.00 0.00 C ATOM 885 02'GUA 28 7.298-2. 898 24.910 1.00 0.00 O ATOM 886 C3'GUA 28 7.767-1. 221 23.202 1.00 0.00 C ATOM 887 03'GUA 28 8. 197-0. 486 24.353 1.00 0.00 0 ATOM 888 1H5'GUA 28 5.076 0.476 21.866 1.00 0.00 H ATOM 889 2H5'GUA 28 6.510 1.196 22.626 1.00 0.00 H ATOM 890 H4'GUA 28 5.786-0. 774 23.897 1.00 0.00 H ATOM 891 Hl'GUA 28 6. 094-4. 009 23.025 1.00 0.00 H ATOM 892 1H2 GUA 28 8.373-8. 077 23.274 1.00 0.00 H ATOM 893 2H2 GUA 28 9.156-8. 912 21.952 1.00 0. 00 H ATOM 894 H1 GUA 28 9.462-7. 972 19.963 1.00 0.00 H ATOM 895 H8 GUA 28 7.118-2. 043 19.979 1.00 0.00 H ATOM 896 H2'GUA 28 8.676-3. 169 23.360 1.00 0.00 H ATOM 897 H02'GUA 28 7.885-2. 383 25.468 1.00 0.00 H ATOM 898 H3'GUA 28 8.386-1. 033 22.324 1.00 0.00 H

ATOM 899 P CYT 29 9.760-0. 170 24.584 1.00 0.00 P ATOM 900 01P CYT 29 10.361 0.178 23.276 1.00 0.00 0 ATOM 901 02P CYT 29 9.879 0. 768 25.722 1.00 0.00 0 ATOM 902 05'CYT 29 10. 345-1. 599 25.041 1.00 0.00 O ATOM 903 C5'CYT 29 10.201-2. 051 26.392 1.00 0.00 C ATOM 904 C4'CYT 29 10.777-3. 452 26.581 1.00 0.00 C ATOM 905 04'CYT 29 10.136-4. 406 25.722 1.00 0.00 0 ATOM 906 C1'CYT 29 11.129-5. 267 25.131 1.00 0.00 C ATOM 907 N1 CYT 29 11.261-5. 016 23.676 1.00 0.00 N ATOM 908 C6 CYT 29 11.054-3. 770 23.156 1.00 0.00 C ATOM 909 C2 CYT 29 11.590-6. 094 22.862 1.00 0.00 C ATOM 910 02 CYT 29 11.778-7. 207 23.351 1.00 0.00 0 ATOM 911 N3 CYT 29 11.699-5. 880 21.522 1.00 0.00 N ATOM 912 C4 CYT 29 11.497-4. 663 21.000 1.00 0.00 C ATOM 913 N4 CYT 29 11.608-4. 491 19.683 1.00 0.00 N ATOM 914 C5 CYT 29 11.161-3. 551 21.832 1.00 0.00 C ATOM 915 C2'CYT 29 12.430-4. 967 25.866 1.00 0.00 C ATOM 916 02'CYT 29 12.561-5. 767 27.047 1.00 0.00 0 ATOM 917 C3'CYT 29 12.248-3. 501 26.200 1.00 0.00 C ATOM 918 03'CYT 29 13.032-3. 189 27.357 1.00 0.00 0 ATOM 919 1H5'CYT 29 9.143-2. 063 26.653 1. 00 0.00 H ATOM 920 2H5'CYT 29 10.723-1. 360 27.055 1.00 0.00 H ATOM 921 H4'CYT 29 10.656-3. 763 27.618 1.00 0.00 H ATOM 922 H1'CYT 29 10.850-6. 308 25.297 1.00 0.00 H ATOM 923 H6 CYT 29 10.801-2. 944 23.819 1.00 0.00 H ATOM 924 1H4 CYT 29 11.455-3. 578 19.279 1.00 0.00 H ATOM 925 2H4 CYT 29 11.848-5. 273 19.090 1.00 0. 00 H ATOM 926 H5 CYT 29 10.997-2. 560 21.410 1.00 0.00 H ATOM 927 H2'CYT 29 13.283-5. 105 25.199 1.00 0.00 H ATOM 928 H02'CYT 29 13.269-5. 387 27.571 1.00 0.00 H ATOM 929 H3'CYT 29 12.475-2. 856 25.350 1.00 0. 00 H ATOM 930 P CYT 30 14.492-2. 527 27.202 1.00 0.00 P ATOM 931 O1P CYT. 30 14.429-1. 509 26.129 1.00 0.00 0 ATOM 932 02P CYT 30 14.975-2. 149 28.550 1.00 0.00 0 ATOM 933 05'CYT 30 15.384-3. 760 26.673 1.00 0.00 0 ATOM 934 C5'CYT 30 15.719-4. 845 27. 545 1.00 0.00 C ATOM 935 C4'CYT 30 16.121-6. 092 26.761 1.00 0.00 C ATOM 936 04'CYT 30 15.104-6. 483 25.833 1.00 0. 00 0 ATOM 937 C1'CYT 30 15.722-6. 972 24.629 1.00 0.00 C ATOM 938 N1 CYT 30 15.378-6. 129 23.462 1.00 0.00 N ATOM 939 C6 CYT 30 15.160-4. 787 23.599 1.00 0.00 C ATOM 940 C2 CYT 30 15.291-6. 753 22. 224 1.00 0.00 C ATOM 941 02 CYT 30 15.495-7. 962 22.123 1.00 0.00 O ATOM 942 N3 CYT 30 14.982-5. 993 21.139 1.00 0.00 N ATOM 943 C4 CYT 30 14.767-4. 677 21.257 1.00 0.00 C ATOM 944 N4 CYT 30 14.471-3. 963 20.172 1. 00 0.00 N ATOM 945 C5 CYT 30 14.853-4. 028 22. 529 1.00 0.00 C ATOM 946 C2'CYT 30 17.227-6. 959 24.894 1.00 0.00 C ATOM 947 02'CYT 30 17. 672-8. 209 25.433 1.00 0.00 0 ATOM 948 C3'CYT 30 17.350-5. 839 25.906 1.00 0.00 C ATOM 949 03'CYT 30 18.560-5. 935 26.667 1.00 0.00 O ATOM 950 1H5'CYT 30 14.857-5. 081 28.169 1.00 0.00 H ATOM 951 2H5'CYT 30 16.549-4. 544 28.184 1.00 0.00 H ATOM 952 H4'CYT 30 16.315-6. 912 27.450 1.00 0. 00 H ATOM 953 Hl'CYT 30 15.397-7. 996 24.447 1.00 0.00 H ATOM 954 H6 CYT 30 15.235-4. 325 24.583 1.00 0.00 H ATOM 955 lH4 CYT 30 14.308-2. 969 20. 250 1.00 0.00 H ATOM 956 2H4 CYT 30 14. 419-4.413 19.270 1.00 0.00 H ATOM 957 H5 CYT 30 14.678-2. 957 22.629 1.00 0.00 H ATOM 958 H2'CYT 30 17.771-6. 708 23. 979 1.00 0.00 H

ATOM 959 H02'CYT 30 17.087-8. 430 26.161 1.00 0.00 H ATOM 960 H3'CYT 30 17.271-4. 869 25.406 1.00 0.00 H ATOM 961 H03'CYT 30 19.291-5. 796 26.060 1.00 0.00 H TER ATOM 962 05'GUA 1 13.376-5. 482-25.018 1.00 0.00 0 ATOM 963 C5'GUA 1 13.169-6. 356-26.131 1.00 0.00 C ATOM 964 C4'GUA 1 13.834-7. 713-25.913 1.00 0.00 C ATOM 965 04'GUA 1 15. 250-7. 578-25.707 1.00 0.00 0 ATOM 966 C1'GUA 1 15.640-8. 325-24.541 1.00 0.00 C ATOM 967 N9 GUA 1 15.890-7. 430-23.393 1.00 0.00 N ATOM 968 C4 GUA 1 16.591-7. 738-22.247 1.00 0.00 C ATOM 969 N3 GUA 1 17.172-8. 926-21.967 1.00 0.00 N ATOM 970 C2 GUA 1 17.779-8. 923-20.777 1.00 0.00 C ATOM 971 N2 GUA 1 18.393-10. 021-20.338 1.00 0.00 N ATOM 972 N1 GUA 1 17.808-7. 829-19.936 1.00 0.00 N ATOM 973 C6 GUA 1 17.221-6. 599-20.200 1.00 0.00 C ATOM 974 06 GUA 1 17.305-5. 686-19.382 1.00 0.00 0 ATOM 975 C5 GUA 1 16.571-6. 594-21.462 1.00 0.00 C ATOM 976 N7 GUA 1 15.866-5. 571-22.100 1.00 0.00 N ATOM 977 C8 GUA 1 15.512-6. 142-23.201 1.00 0.00 C ATOM 978 C2'GUA 1 14.479-9. 265-24.260 1.00 0.00 C ATOM 979 02'GUA 1 14.554-10. 449-25.063 1.00 0.00 0 ATOM 980 C3'GUA 1 13.307-8. 391-24. 655 1.00 0. 00 C ATOM 981 03'GUA 1 12.205-9. 230-25.011 1.00 0.00 0 ATOM 982 H5'GUA 1 12.953-5. 885-24.257 1.00 0.00 H ATOM 983 1H5'GUA 1 13.586-5. 896-27.027 1.00 0.00 H ATOM 984 2H5'GUA 1 12.098-6. 504-26.273 1.00 0.00 H ATOM 985 H4'GUA 1 13.655-8. 353-26.776 1.00 0.00 H ATOM 986 Hl'GUA 1 16.537-8. 904-24.759 1.00 0.00 H ATOM 987 1H2 GUA 1 18.400-10. 856-20.906 1.00 0.00 H ATOM 988 2H2 GUA 1 18. 852-10.018-19. 438 1. 00 0.00 H ATOM 989 Hl GUA 1 18.289-7. 907-19.054 1.00 0.00 H ATOM 990 H8 GUA 1 14.923-5. 612-23.948 1.00 0.00 H ATOM 991 H2'GUA 1 14.436-9. 509-23.196 1.00 0.00 H ATOM 992 H02'GUA 1 14.644-10. 169-25.977 1.00 0.00 H ATOM 993 H3'GUA 1 13.054-7. 671-23.874 1.00 0.00 H ATOM 994 P GUA 2 11. 130-9. 682-23.899 1.00 0.00 P ATOM 995 01P GUA 2 10.668-8. 473-23.182 1.00 0.00 O ATOM 996 02P GUA 2 10.145-10. 578-24.546 1.00 0.00 0 ATOM 997 05'GUA 2 12.023-10. 559-22.886 1.00 0.00 0 ATOM 998 C5'GUA 2 12.553-11. 824-23.294 1.00 0.00 C ATOM 999 C4'GUA 2 13. 550-12. 373-22.278 1.00 0.00 C ATOM 1000 04'GUA 2 14.649-11. 480-22.073 1.00 0.00 O ATOM 1001 C1'GUA 2 15.040-11. 514-20.686 1.00 0.00 C ATOM 1002 N9 GUA 2 14.883-10. 188-20.051 1.00 0.00 N ATOM 1003 C4 GUA 2 15.460-9. 770-18.870 1.00 0.00 C ATOM 1004 N3 GUA 2 16.258-10. 513-18.070 1.00 0.00 N ATOM 1005 C2 GUA 2 16.669-9. 834-16.994 1.00 0.00 C ATOM 1006 N2 GUA 2 17.460-10. 423-16.097 1.00 0.00 N ATOM 1007 N1 GUA 2 16. 317-8. 525-16.734 1.00 0. 00 N ATOM 1008 C6 GUA 2 15.499-7. 742-17.539 1.00 0.00 C ATOM 1009 06 GUA 2 15.249-6. 583-17.220 1.00 0.00 O ATOM 1010 C5 GUA 2 15.057-8. 456-18.685 1.00 0.00 C ATOM 1011 N7 GUA 2 14.231-8. 042-19.733 1.00 0.00 N ATOM 1012 C8 GUA 2 14.187-9. 101-20.470 1.00 0.00 C ATOM 1013 C2'GUA 2 14.145-12. 557-20.017 1.00 0.00 C ATOM 1014 02'GUA 2 14.760-13. 852-20.012 1.00 0.00 O ATOM 1015 C3'GUA 2 12. 920-12. 525-20.908 1.00 0.00 C ATOM 1016 03'GUA 2 12.264-13. 795-20. 846 1.00 0.00 O ATOM 1017 1H5'GUA 2 13.053-11. 707-24.255 1.00 0. 00 H

ATOM 1018 2H5'GUA 2 11.732-12. 533-23.405 1.00 0.00 H ATOM 1019 H4'GUA 2 13.928-13. 336-22.617 1.00 0.00 H ATOM 1020 Hl'GUA 2 16.081-11. 831-20.613 1.00 0.00 H ATOM 1021 1H2 GUA 2 17.748-11. 381-16.231 1.00 0.00 H ATOM 1022 2H2 GUA 2 17.774-9. 909-15.286 1.00 0.00 H ATOM 1023 Hl GUA 2 16.675-8. 079-15.901 1.00 0.00 H ATOM 1024 H8 GUA 2 13.612-9. 119-21.396 1.00 0.00 H ATOM 1025 H2'GUA 2 13.889-12. 240-19.004 1.00 0.00 H ATOM 1026 H02'GUA 2 14.899-14. 105-20.927 1.00 0.00 H ATOM 1027 H3'GUA 2 12.258-11. 693-20.662 1.00 0.00 H ATOM 1028 P CYT 3 11.115-14. 070-19.751 1.00 0.00 P ATOM 1029 O1P CYT 3 10.464-15. 359-20.077 1.00 0.00 0 ATOM 1030 02P CYT 3 10.296-12. 844-19.619 1.00 0.00 0 ATOM 1031 05'CYT 3 11.963-14. 258-18.396 1.00 0.00 0 ATOM 1032 C5'CYT 3 12.621-15. 496-18. 114 1. 00 0.00 C ATOM 1033 C4'CYT 3 13.348-15. 450-16.773 1.00 0.00 C ATOM 1034 04'CYT 3 14.410-14. 483-16.775 1.00 0.00 0 ATOM 1035 C1'CYT 3 14.364-13. 720-15.553 1.00 0.00 C ATOM 1036 N1 CYT 3 13.898-12. 336-15.801 1.00 0.00 N ATOM 1037 C6 CYT 3 12.968-12. 072-16.766 1.00 0.00 C ATOM 1038 C2 CYT 3 14.438-11. 322-15.021 1.00 0.00 C ATOM 1039 02 CYT 3 15.270-11. 582-14.153 1.00 0.00 0 ATOM 1040 N3 CYT 3 14.017-10. 046-15.242 1.00 0.00 N ATOM 1041 C4 CYT 3 13.107-9. 775-16.186 1.00 0.00 C ATOM 1042 N4 CYT 3 12.722-8. 514-16.381 1.00 0.00 N ATOM 1043 C5 CYT 3 12.547-10. 816-16.989 1.00 0.00 C ATOM 1044 C2'CYT 3 13.399-14. 469-14.642 1.00 0.00 C ATOM 1045 02'CYT 3 14.058-15. 524-13.931 1.00 0.00 0 ATOM 1046 C3'CYT 3 12.415-15. 006-15.658 1.00 0.00 C ATOM 1047 03'CYT 3 11.762-16. 157-15.114 1.00 0.00 0 ATOM 1048 1H5'CYT 3 13.343-15. 705-18.904 1.00 0.00 H ATOM 1049 2H5'CYT 3 11.879-16. 294-18. 088 1.00 0.00 H ATOM 1050 H4'CYT 3 13.755-16. 433-16.542 1.00 0.00 H ATOM 1051 Hl'CYT 3 15.355-13. 698-15.098 1.00 0.00 H ATOM 1052 H6 CYT 3 12. 566-12. 887-17.367 1.00 0.00 H ATOM 1053 1H4 CYT 3 12.039-8. 299-17.093 1.00 0.00 H ATOM 1054 2H4 CYT 3 13. 113-7. 774-15.816 1.00 0.00 H ATOM 1055 H5 CYT 3 11.801-10. 601-17.752 1.00 0.00 H ATOM 1056 H2'CYT 3 12.906-13. 776-13.956 1.00 0.00 H ATOM 1057 H02'CYT 3 14.563-16. 029-14.573 1.00 0.00 H ATOM 1058 H3'CYT 3 11.713-14. 238-15.991 1.00 0.00 H ATOM 1059 P GUA 4 10.300-16. 024-14. 453 1.00 0.00 P ATOM 1060 O1P GUA 4 9.837-17. 378-14.076 1.00 0.00 0 ATOM 1061 02P GUA 4 9.466-15. 178-15.336 1.00 0.00 0 ATOM 1062 05'GUA 4 10.602-15. 198-13.104 1.00 0.00 0 ATOM 1063 C5'GUA 4 11.308-15. 811-12.022 1.00 0.00 C ATOM 1064 C4'GUA 4 11.815-14. 777-11. 020 1.00 0.00 C ATOM 1065 04'GUA 4 12.695-13. 829-11.632 1.00 0.00 0 ATOM 1066 C1'GUA 4 12.476-12. 531-11.043 1.00 0.00 C ATOM 1067 N9 GUA 4 11. 990-11. 558-12. 042 1.00 0.00 N ATOM 1068 C4 GUA 4 12.030-10. 187-11.930 1.00 0.00 C ATOM 1069 N3 GUA 4 12.546-9. 493-10.892 1.00 0.00 N ATOM 1070 C2 GUA 4 12. 439-8. 174-11. 063 1.00 0. 00 C ATOM 1071 N2 GUA 4 12.902-7. 344-10.129 1.00 0.00 N ATOM 1072 N1 GUA 4 11.867-7. 589-12.176 1.00 0.00 N ATOM 1073 C6 GUA 4 11.333-8. 280-13.256 1.00 0.00 C ATOM 1074 06 GUA 4 10.849-7. 665-14.203 1.00 0.00 0 ATOM 1075 C5 GUA 4 11. 441-9. 685-13.081 1.00 0.00 C ATOM 1076 N7 GUA 4 11.031-10. 728-13.918 1.00 0.00 N ATOM 1077 C8 GUA 4 11.387-11. 766-13. 239 1.00 0.00 C

ATOM 1078 C2'GUA 4 11.441-12. 735-9.939 1.00 0.00 C ATOM 1079 02'GUA 4 12. 065-13. 012-8. 679 1.00 0.00 0 ATOM 1080 C3'GUA 4 10. 682-13. 935-10.465 1.00 0.00 C ATOM 1081 03'GUA 4 10.083-14. 626-9.365 1.00 0.00 0 ATOM 1082 1H5'GUA 4 12.158-16. 366-12.419 1.00 0. 00 H ATOM 1083 2H5'GUA 4 10.640-16. 504-11.510 1.00 0.00 H ATOM 1084 H4'GUA 4 12.335-15. 278-10.205 1.00 0.00 H ATOM 1085 Hl'GUA 4 13. 407-12. 169-10.606 1.00 0.00 H ATOM 1086 1H2 GUA 4 13.333-7. 713-9.294 1.00 0.00 H ATOM 1087 2H2 GUA 4 12.813-6. 346-10.252 1.00 0. 00 H ATOM 1088 Hl GUA 4 11.812-6. 583-12.225 1.00 0.00 H ATOM 1089 H8 GUA 4 11.204-12. 773-13.612 1.00 0.00 H ATOM 1090 H2'GUA 4 10.782-11. 866-9. 872 1.00 0.00 H ATOM 1091 H02'GUA 4 12.392-12. 179-8.333 1.00 0.00 H ATOM 1092 H3'GUA 4 9.960-13. 657-11.234 1.00 0.00 H ATOM 1093 P CYT 5 8.693-14. 109-8.737 1.00 0.00 P ATOM 1094 01P CYT 5 8.208-15. 129-7.781 1.00 0.00 0 ATOM 1095 02P CYT 5 7.820-13. 664-9.847 1.00 0.00 0 ATOM 1096 05'CYT 5 9.147-12. 809-7.902 1.00 0.00 0 ATOM 1097 C5'CYT 5 9.903-12. 950-6.695 1.00 0.00 C ATOM 1098 C4'CYT 5 10.280-11. 595-6.104 1.00 0. 00 C ATOM 1099 04'CYT 5 11.077-10. 822-7. 008 1. 00 0.00 O ATOM 1100 Cl'CYT 5 10.687-9. 436-6.927 1.00 0.00 C ATOM 1101 N1 CYT 5 10.119-8. 961-8.209 1.00 0.00 N ATOM 1102 C6 CYT 5 9.405-9. 800-9.016 1.00 0.00 C ATOM 1103 C2 CYT 5 10.337-7. 634-8.558 1.00 0.00 C ATOM 1104 02 CYT 5 10.984-6. 896-7.817 1.00 0.00 0 ATOM 1105 N3 CYT 5 9.820-7. 183-9.734 1.00 0.00 N ATOM 1106 C4 CYT 5 9.118-7. 995-10.534 1.00 0.00 C ATOM 1107 N4 CYT 5 8.629-7. 520-11.680 1.00 0.00 N ATOM 1108 C5 CYT 5 8.891-9. 362-10.179 1.00 0.00 C ATOM 1109 C2'CYT 5 9.655-9. 352-5.804 1.00 0.00 C ATOM 1110 02'CYT 5 10.273-9. 079-4. 540 1.00 0.00 O ATOM 1111 C3'CYT 5 9.052-10. 742-5. 845 1.00 0.00 C ATOM 1112 03'CYT 5 8.535-11. 069-4.551 1.00 0.00 O ATOM 1113 1H5'CYT 5 10.813-13. 510-6.909 1.00 0.00 H ATOM 1114 2H5'CYT 5 9.308-13. 502-5.967 1.00 0.00 H ATOM 1115 H4'CYT 5 10.828-11. 739-5.174 1.00 0.00 H ATOM 1116 H1'CYT 5 11.556-8. 830-6.667 1.00 0.00 H ATOM 1117 H6 CYT 5 9.250-10. 836-8.715 1.00 0.00 H ATOM 1118 1H4 CYT 5 8.788-6. 556-11.935 1.00 0.00 H ATOM 1119 2H4 CYT 5 8. 100-8. 124-12.292 1.00 0.00 H ATOM 1120 H5 CYT 5 8.319-10. 025-10.827 1.00 0.00 H ATOM 1121 H2'CYT 5 8.900-8. 600-6.043 1.00 0.00 H ATOM 1122 H02'CYT 5 10.576-8. 168-4.562 1.00 0.00 H ATOM 1123 H3'CYT 5 8.305-10. 840-6.636 1.00 0.00 H ATOM 1124 P URI 6 6.999-10. 762-4.178 1.00 0.00 P ATOM 1125 01P URI 6 6.169-11. 019-5.376 1.00 0.00 0 ATOM 1126 02P URI 6 6.686-11. 444-2.902 1.00 0.00 0 ATOM 1127 05'URI 6 7.018-9. 176-3.912 1. 00 0.00 0 ATOM 1128 C5'URI 6 7. 758-8. 632-2.815 1.00 0.00 C ATOM 1129 C4'URI 6 7.730-7. 108-2.823 1.00 0.00 C ATOM 1130 04'URI 6 8.296-6. 574-4.029 1.00 0.00 0 ATOM 1131 C1'URI 6 7.473-5. 492-4.507 1.00 0.00 C ATOM 1132 NI URI 6 6.776-5. 856-5.764 1.00 0.00 N ATOM 1133 C6 URI 6 6.548-7. 166-6.095 1. 00 0.00 C ATOM 1134 C2 URI 6 6.375-4. 822-6.595 1.00 0.00 C ATOM 1135 02 URI 6 6.568-3. 641-6.313 1.00 0.00 0 ATOM 1136 N3 URI 6 5. 740-5. 195-7.765 1.00 0.00 N ATOM 1137 C4 URI 6 5.474-6. 490-8.174 1.00 0. 00 C

ATOM 1138 04 URI 6 4.912-6. 705-9.245 1.00 0.00 0 ATOM 1139 C5 URI 6 5.923-7. 505-7.248 1.00 0.00 C ATOM 1140 C2'URI 6 6.479-5. 204-3.389 1.00 0.00 C ATOM 1141 02'URI 6 7.015-4. 278-2.435 1.00 0.00 O ATOM 1142 C3'URI 6 6.305-6. 584-2.793 1.00 0.00 C ATOM 1143 03'URI 6 5.891-6. 456-1.430 1.00 0.00 0 ATOM 1144 1H5'URI 6 8.793-8. 970-2.881 1.00 0.00 H ATOM 1145 2H5'URI 6 7. 325-8. 991-1.881 1.00 0.00 H ATOM 1146 H4'URI 6 8.281-6. 725-1.965 1.00 0.00 H ATOM 1147 Hl'URI 6 8.092-4. 611-4.676 1.00 0.00 H ATOM 1148 H6 URI 6 6.875-7. 953-5.415 1.00 0. 00 H ATOM 1149 H3 URI 6 5.437-4. 450-8.378 1.00 0.00 H ATOM 1150 H5 URI 6 5.754-8. 557-7.481 1.00 0.00 H ATOM 1151 H2'URI 6 5.537-4. 842-3.804 1.00 0.00 H ATOM 1152 H02'URI 6 7.040-3. 416-2.858 1.00 0.00 H ATOM 1153 H3'URI 6 5.627-7. 202-3.385 1.00 0.00 H ATOM 1154 P CYT 7 4.331-6. 542-1.038 1.00 0.00 P ATOM 1155 01P CYT 7 4.224-6. 552 0.438 1.00 0.00 0 ATOM 1156 02P CYT 7 3.713-7. 630-1.830 1.00 0.00 0 ATOM 1157 05'CYT 7 3.758-5. 139-1.579 1.00 0.00 0 ATOM 1158 C5'CYT 7 4.285-3. 904-1.088 1.00 0.00 C ATOM 1159 C4'CYT 7 3.979-2. 744-2.032 1.00 0.00 C ATOM 1160 04'CYT 7 4.430-3. 013-3.367 1.00 0.00 O ATOM 1161 C1'CYT 7 3.454-2. 521-4.309 1.00 0.00 C ATOM 1162 Nl CYT 7 2.811-3. 623-5.062 1.00 0.00 N ATOM 1163 C6 CYT 7 3. 022-4. 931-4.727 1.00 0.00 C ATOM 1164 C2 CYT 7 1.977-3. 273-6.116 1.00 0.00 C ATOM 1165 02 CYT 7 1.800-2. 090-6.399 1.00 0.00 0 ATOM 1166 N3 CYT 7 1.368-4. 268-6.815 1.00 0.00 N ATOM 1167 C4 CYT 7 1.565-5. 552-6.499 1.00 0.00 C ATOM 1168 N4 CYT 7 0.947-6. 498-7.204 1.00 0.00 N ATOM 1169 C5 CYT 7 2.423-5. 921-5. 415. 1.00 0.00 C ATOM 1170 C2'CYT 7 2.424-1. 761-3.481 1.00 0.00 C ATOM 1171 02'CYT 7 2.793-0. 386-3.314 1.00 0.00 O ATOM 1172 C3'CYT 7 2.485-2. 519-2.172 1.00 0.00 C ATOM 1173 03'CYT 7 2.043-1. 656-1.120 1.00 0.00 0 ATOM 1174 1H5'CYT 7 5.366-3. 996-0.980 1.00 0.00 H ATOM 1175 2H5'CYT 7 3.847-3. 693-0.112 1.00 0.00 H ATOM 1176 H4'CYT 7 4.456-1. 836-1.667 1.00 0.00 H ATOM 1177 H1'CYT 7 3.937-1. 836-5.007 1.00 0.00 H ATOM 1178 H6 CYT 7 3.676-5. 175-3.891 1.00 0.00 H ATOM 1179 1H4 CYT 7 1.085-7. 471-6.974 1.00 0.00 H ATOM 1180 2H4 CYT 7 0.340-6. 240-7.969 1.00 0.00 H ATOM 1181 H5 CYT 7 2.588-6. 967-5.156 1.00 0.00 H ATOM 1182 H2'CYT 7 1.432-1. 852-3.931 1.00 0.00 H ATOM 1183 H02'CYT 7 3.677-0. 371-2.941 1.00 0.00 H ATOM 1184 H3'CYT 7 1.928-3. 456-2.215 1.00 0.00 H ATOM 1185 P ADE 8 0.483-1. 583-0.728 1.00 0.00 P ATOM 1186 O1P ADE 8 0.035-2. 944-0.355 1.00 0.00 0 ATOM 1187 02P ADE 8 0.294-0. 460 0.218 1.00 0.00 0 ATOM 1188 05'ADE 8-0.213-1. 190-2.126 1.00 0. 00 0 ATOM 1189 C5'ADE 8-0.092 0.133-2. 658 1.00 0.00 C ATOM 1190 C4'ADE 8-0. 990. 0.331-3. 876 1. 00 0. 00 C ATOM 1191 04'ADE 8-0.623-0. 543-4.955 1.00 0.00 0 ATOM 1192 C1'ADE 8-1.811-1. 144-5.509 1.00 0.00 C ATOM 1193 N9 ADE 8-1.904-2. 576-5.150 1.00 0.00 N ATOM 1194 C4 ADE 8-2.791-3. 502-5. 661 1.00 0.00 C ATOM 1195 N3 ADE 8-3.744-3. 275-6.589 1.00 0.00 N ATOM 1196 C2 ADE 8-4.428-4. 384-6.861 1.00 0.00 C ATOM 1197 N1 ADE 8-4.250-5. 593-6.325 1.00 0.00 N

ATOM 1198 C6 ADE 8-3.294-5. 794-5.402 1.00 0.00 C ATOM 1199 N6 ADE 8-3.134-7. 009-4.880 1.00 0.00 N ATOM 1200 C5 ADE 8-2. 509,-4. 695-5.036 1.00 0.00 C ATOM 1201 N7 ADE 8-1. 453-4.547-4. 132 1.00 0.00 N ATOM 1202 C8 ADE 8-1.170-3. 295-4.264 1.00 0.00 C ATOM 1203 C2'ADE 8-2.975-0. 355-4.929 1.00 0. 00 C ATOM 1204 02'ADE 8-3. 245 0.828-5. 692 1.00 0.00 0 ATOM 1205 C3'ADE 8-2.431-0. 026-3.557 1.00 0.00 C ATOM 1206 03'ADE 8-3.102 1.132-3. 051 1.00 0.00 0 ATOM 1207 1H5'ADE 8 0.944 0.310-2. 946 1. 00 0.00 H ATOM 1208 2H5'ADE 8-0.375 0.852-1. 888 1.00 0.00 H ATOM 1209 H4'ADE 8-0.933 1.365-4. 213 1.00 0.00 H ATOM 1210 H1'ADE 8-1.803-1. 038-6.592 1.00 0.00 H ATOM 1211 H2 ADE 8-5.223-4. 297-7. 604 1.00 0.00 H ATOM 1212 1H6 ADE 8-3.727-7. 769-5.179 1. 00 0.00 H ATOM 1213 2H6 ADE 8-2.418-7. 170-4.185 1.00 0.00 H ATOM 1214 H8 ADE 8-0.372-2. 833-3.684 1.00 0.00 H ATOM 1215 H2'ADE 8-3.862-0. 988-4.850 1.00 0.00 H ATOM 1216 H02'ADE 8-3.642 0. 548-6. 520 1.00 0.00 H ATOM 1217 H3'ADE 8-2. 499-0.878-2. 882 1.00 0.00 H ATOM 1218 P ADE 9-3.160 1.414-1. 465 1.00 0.00 P ATOM 1219 01P ADE 9-1.820 1.855-1. 021 1.00 0.00 0 ATOM 1220 02P ADE 9-4.343 2.260-1. 190 1.00 0.00 0 ATOM 1221 05'ADE 9-3.437-0. 053-0.855 1.00 0.00 0 ATOM 1222 C5'ADE 9-3.661-0. 231 0.548 1.00 0.00 C ATOM 1223 C4'ADE 9-4.041-1. 674 0.885 1.00 0.00 C ATOM 1224 04'ADE 9-5.153-2. 115 0.100 1.00 0.00 0 ATOM 1225 C1'ADE 9-4.704-3. 029-0.915 1.00 0.00 C ATOM 1226 N9 ADE 9-5.249-2. 654-2.234 1.00 0.00 N ATOM 1227 C4 ADE 9-5.978-3. 456-3.079 1.00 0.00 C ATOM 1228 N3 ADE 9-6.315-4. 740-2.864 1.00 0.00 N ATOM 1229 C2 ADE 9-7.024-5. 227-3.874 1.00 0.00 C ATOM 1230 N1 ADE 9-7.390-4. 589-4.986 1.00 0.00 N ATOM 1231 C6 ADE 9-7.042-3. 305-5.178 1.00 0.00 C ATOM 1232 N6 ADE 9-7.421-2. 683-6.294 1.00 0.00 N ATOM 1233 C5 ADE 9-6.291-2. 686-4.175 1.00 0.00 C ATOM 1234 N7 ADE 9-5.769-1. 397-4.041 1.00 0.00 N ATOM 1235 C8 ADE 9-5. 186-1.473-2. 892 1.00 0. 00 C ATOM 1236 C2'ADE 9-3.181-2. 959-0.899 1.00 0.00 C ATOM 1237 02'ADE 9-2.588-4. 203-1. 291 1.00 0.00 0 ATOM 1238 C3'ADE 9-2.914-2. 644 0.558 1.00 0.00 C ATOM 1239 03'ADE 9-3.110-3. 847 1.314 1.00 0.00 0 ATOM 1240 1H5'ADE 9-4.468 0.431 0.864 1.00 0.00 H ATOM 1241 2H5'ADE 9-2.752 0.033 1.090 1.00 0.00 H ATOM 1242 H4'ADE 9-4.296-1. 746 1.941 1.00 0.00 H ATOM 1243 Hl'ADE 9-5.022-4. 040-0.664 1. 00' 0.00 H ATOM 1244 H2 ADE 9-7.352-6. 257-3. 777 1. 00 0.00 H ATOM 1245 1H6 ADE 9-7. 166-1. 718-6.445 1.00 0.00 H ATOM 1246 2H6 ADE 9-7.963-3. 178-6. 989 1.00 0.00 H ATOM 1247 H8 ADE 9-4. 666-0.617-2. 468 1.00 0.00 H ATOM 1248 H2'ADE 9-2.832-2. 139-1.527 1.00 0.00 H ATOM 1249 H02'ADE 9-2.887-4. 869-0.668 1.00 0.00 H ATOM 1250 H3'ADE 9-1.929-2. 205 0.716 1.00 0.00 H ATOM 1251 P URI 10-2.955-3. 870 2.919 1.00 0.00 P ATOM 1252 01P URI 10-1.594-4. 351 3.245 1.00 0.00 0 ATOM 1253 02P URI 10-3.430-2. 576 3.460 1.00 0.00 0 ATOM 1254 05'URI 10-4.007-5. 016 3.340 1.00 0.00 0 ATOM 1255 C5'URI 10-5.114-4. 735 4. 205 1.00 0.00 C ATOM 1256 C4'URI 10-6.453-5. 023 3.519 1. 00 0.00 C ATOM 1257 04'URI 10-6.387-6. 195 2.707 1. 00 0. 00 O

ATOM 1258 C1'URI 10-6.859-7. 329 3.461 1.00 0.00 C ATOM 1259 N1 URI 10-5.797-8. 353 3.589 1.00 0.00 N ATOM 1260 C6 URI 10-4.509-8. 078 3.215 1.00 0.00 C ATOM 1261 C2 URI 10-6.151-9. 590 4.104 1.00 0.00 C ATOM 1262 02 URI 10-7.303-9. 858 4.441 1.00 0.00 0 ATOM 1263 N3 URI 10-5.129-10. 515 4.215 1.00 0.00 N ATOM 1264 C4 URI 10-3.805-10. 318 3.862 1.00 0.00 C ATOM 1265 04 URI 10-2.978-11. 215 4.006 1.00 0.00 0 ATOM 1266 C5 URI 10-3.527-9. 001 3.335 1.00 0.00 C ATOM 1267 C2'URI 10-7.276-6. 791 4. 834'1. 00 0.00 C ATOM 1268 02'URI 10-8.451-7. 446 5.326 1.00 0.00 0 ATOM 1269 C3'URI 10-7.538-5. 325 4.533 1.00 0.00 C ATOM 1270 03'URI 10-8.813-5. 218 3.883 1.00 0.00 0 ATOM 1271 1H5'URI 10-5.084-3. 687 4.503 1.00 0.00 H ATOM 1272 2H5'URI 10-5.030-5. 358 5.096 1.00 0.00 H ATOM 1273 H4'URI 10-6.745-4. 172 2.907 1.00 0.00 H ATOM 1274 H1'URI 10-7.726-7. 763 2.962 1.00 0.00 H ATOM 1275 H6 URI 10-4.269-7. 096 2.807 1.00 0.00 H ATOM 1276 H3 URI 10-5.372-11. 421 4.588 1.00 0.00 H ATOM 1277 H5 URI 10-2.513-8. 745 3.030 1.00 0.00 H ATOM 1278 H2'URI 10-6.447-6. 884 5.541 1.00 0.00 H ATOM 1279 H02'URI 10-9.142-7. 324 4.670 1.00 0.00 H ATOM 1280 H3'URI 10-7. 464-4.696 5.421 1.00 0.00 H ATOM 1281 P GUA 11-9.629-3. 828 3.883 1.00 0.00 P ATOM 1282 01P GUA 11-9.288-3. 088 5.120 1.00 0.00 0 ATOM 1283 02P GUA 11-11.045-4. 125 3.571 1.00 0.00 0 ATOM 1284 05'GUA 11-8.995-3. 040 2.629 1.00 0.00 0 ATOM 1285 C5'GUA 11-8.673-1. 649 2.729 1.00 0.00 C ATOM 1286 C4'GUA 11-8.546-0. 997 1.354 1.00 0.00 C ATOM 1287 04'GUA 11-7.609-1. 700 0. 523 1.00 0.00 0 ATOM 1288 C1'GUA 11-8.190-1. 912-0.776 1.00 0.00 C ATOM 1289 N9 GUA 11-8.632-3. 308-0.942 1.00 0.00 N ATOM 1290 C4 GUA 11-9.246-3. 841-2.049 1.00 0.00 C ATOM 1291 N3 GUA 11-9.535-3. 175-3.188 1.00 0.00 N ATOM 1292 C2 GUA 11-10. 133-3.954-4. 089 1.00 0.00 C ATOM 1293 N2 GUA 11-10.480-3. 454-5.274 1.00 0.00 N ATOM 1294 N1 GUA 11-10. 423-5.287-3. 877 1.00 0.00 N ATOM 1295 C6 GUA 11-10.135-5. 994-2.717 1.00 0.00 C ATOM 1296 06 GUA 11-10.436-7. 181-2.628 1.00 0.00 0 ATOM 1297 C5 GUA 11-9.497-5. 171-1.752 1.00 0.00 C ATOM 1298 N7 GUA 11-9.045-5. 481-0.466 1.00 0.00 N ATOM 1299 C8 GUA 11-8.562-4. 348-0.078 1.00 0.00 C ATOM 1300 C2'GUA 11-9.373-0. 959-0.841 1.00 0.00 C ATOM 1301 02'GUA 11-8.964 0.370-1. 187 1.00 0.00 O ATOM 1302 C3'GUA 11-9.861-1. 042 0.589 1.00 0.00 C ATOM 1303 03'GUA 11-10.616 0.135 0.891 1.00 0.00 0 ATOM 1304 1H5'GUA 11-7.727-1. 542 3.261 1.00 0.00 H ATOM 1305 2H5'GUA 11-9.456-1. 141 3.292 1.00 0.00 H ATOM 1306 H4'GUA 11-8.222 0.037 1.466 1.00 0.00 H ATOM 1307 H1'GUA 11-7.467-1. 663-1.553 1.00 0.00 H ATOM 1308 1H2 GUA 11-10.933-4. 043-5.957 1.00 0.00 H ATOM 1309 2H2 GUA 11-10.288-2. 486-5.490 1.00 0.00 H ATOM 1310 H1 GUA 11-10.885-5. 806-4.608 1.00 0.00 H ATOM 1311 H8 GUA 11-8.117-4. 231 0.908 1.00 0.00 H ATOM 1312 H2'GUA 11-10.132-1. 336-1.533 1.00 0.00 H ATOM 1313 H02'GUA 11-9. 686 0.959-0. 956 1.00 0.00 H ATOM 1314 H3'GUA 11-10.416-1. 963 0.778 1.00 0.00 H ATOM 1315 P CYT 12-12. 222 0.064 1.004 1.00 0.00 P ATOM 1316 01P CYT 12-12.576-1. 108 1.835 1.00 0. 00 0 ATOM 1317 02P CYT 12-12.720 1.408 1.372 1. 00 0. 00 O

ATOM 1318 05'CYT 12-12.665-0. 242-0.513 1.00 0.00 0 ATOM 1319 C5'CYT 12-12.513 0. 754-1. 528 1.00 0.00 C ATOM 1320 C4'CYT 12-12.862 0.210-2. 910 1.00 0.00 C ATOM 1321 04'CYT 12-12.029-0. 897-3.273 1.00 0.00 0 ATOM 1322 Cl'CYT 12-12.825-1. 898-3.940 1.00 0.00 C ATOM 1323 N1 CYT 12-12.906-3. 143-3.142 1.00 0.00 N ATOM 1324 C6 CYT 12-12.522-3. 169-1.830 1.00 0.00 C ATOM 1325 C2 CYT 12-13.367-4. 287-3.783 1.00 0.00 C ATOM 1326 02 CYT 12-13.720-4. 240-4. 960 1.00 0.00 O ATOM 1327 N3 CYT 12-13.422-5. 446-3.073 1.00 0.00 N ATOM 1328 C4 CYT 12-13. 046-5. 486-1.789 1.00 0.00 C ATOM 1329 N4 CYT 12-13.097-6. 643-1.131 1.00 0.00 N ATOM 1330 C5 CYT 12-12.577-4. 313-1.121 1.00 0.00 C ATOM 1331 C2'CYT 12-14. 203-1.274-4. 138 1.00 0.00 C ATOM 1332 02'CYT 12-14.282-0. 561-5.377 1.00 0.00 O ATOM 1333 C3'CYT 12-14.277-0. 340-2.949 1.00 0.00 C ATOM 1334 03'CYT 12-15.175 0.731-3. 253 1.00 0. 00 0 ATOM 1335 1H5'CYT 12-11.480 1.101-1. 534 1.00 0.00 H ATOM 1336 2H5'CYT 12-13.169 1. 594-1. 301 1.00 0.00 H ATOM 1337 H4'CYT 12-12.756 0.999-3. 653 1.00 0.00 H ATOM 1338 Hl'CYT 12-12.387-2. 118-4.914 1.00 0.00 H ATOM 1339 H6 CYT 12-12.161-2. 258-1.353 1.00 0.00 H ATOM 1340 1H4 CYT 12-12.807-6. 688-0.165 1.00 0.00 H ATOM 1341 2H4 CYT 12-13. 418-7.477-1. 602 1.00 0.00 H ATOM 1342 H5 CYT 12-12.279-4. 343-0.073 1.00 0.00 H ATOM 1343 H2'CYT 12-14.979-2. 040-4.073 1.00 0.00 H ATOM 1344 H02'CYT 12-13. 529 0.034-5. 411 1.00 0.00 H ATOM 1345 H3'CYT 12-14.543-0. 869-2.032 1.00 0.00 H ATOM 1346 P URI 13-16.713 0.662-2. 785 1.00 0.00 P ATOM 1347 01P URI 13-16.749 0.222-1. 372 1.00 0.00 O ATOM 1348 02P URI 13-17.376 1.924-3. 182 1.00 0.00 O ATOM 1349 05'URI 13-17.298-0. 527-3.697 1.00 0.00 O ATOM 1350 C5'URI 13-17.516-0. 330-5.096 1.00 0.00 C ATOM 1351 C4'URI 13-17.914-1. 629-5.787 1.00 0.00 C ATOM 1352 04'URI 13-16.883-2. 616-5.699 1.00 0.00 0 ATOM 1353 C1'URI 13-17.480-3. 916-5.516 1.00 0.00 C ATOM 1354 N1 URI 13-17.076-4. 523-4.227 1. 00 0. 00 N ATOM 1355 C6 URI 13-16.680-3. 748-3.167 1.00 0.00 C ATOM 1356 C2 URI 13-17.109-5. 904-4.137 1.00 0. 00 C ATOM 1357 02 URI 13-17. 467-6. 615-5.074 1.00 0.00 0 ATOM 1358 N3 URI 13-16.718-6. 444-2.928 1.00 0.00 N ATOM 1359 C4 URI 13-16.302-5. 739-1.813 1.00 0. 00 C ATOM 1360 04 URI 13-15.963-6. 329-0.790 1.00 0.00 O ATOM 1361 C5 URI 13-16.301-4. 304-1.991 1.00 0.00 C ATOM 1362 C2'URI 13-18.992-3. 702-5.573 1.00 0.00 C ATOM 1363 02'URI 13-19.497-3. 872-6.904 1.00 0.00 0 ATOM 1364 C3'URI 13-19.110-2. 266-5.108 1.00 0.00 C ATOM 1365 03'URI 13-20.306-1. 698-5.649 1.00 0.00 0 ATOM 1366 1H5'URI 13-16.600 0.049-5. 551 1.00 0.00 H ATOM 1367 2H5'URI 13-18.311 0.404-5. 232 1.00 0.00 H ATOM 1368 H4'URI 13-18.143-1. 436-6.834 1.00 0.00 H ATOM 1369 H1'URI 13-17. 177-4.569-6. 335 1.00 0.00 H ATOM 1370 H6 URI 13-16.671-2. 662-3.270 1.00 0.00 H ATOM 1371 H3 URI 13-16. 742-7. 450-2. 850 1. 00 0.00 H ATOM 1372 H5 URI 13-15.991-3. 661-1.167 1.00 0.00 H ATOM 1373 H2'URI 13-19.495-4. 372-4.873 1.00 0. 00 H ATOM 1374 H02'URI 13-19. 390-4. 798-7. 133 1.00 0.00 H ATOM 1375 H3'URI 13-19. 058-2. 184-4. 021 1.00 0.00 H ATOM 1376 P CYT 14-21. 686-1. 767-4. 822 1.00 0.00 P ATOM 1377 01P CYT 14-21. 387-1. 490-3.398 1.00 0.00 0

ATOM 1378 02P CYT 14-22.696-0. 952-5.535 1.00 0. 00 O ATOM 1379 05'CYT 14-22.097-3. 317-4.956 1.00 0.00 0 ATOM 1380 C5'CYT 14-22.683-3. 814-6.163 1.00 0.00 C ATOM 1381 C4'CYT 14-22. 927-5. 319-6.090 1.00 0.00 C ATOM 1382 04'CYT 14-21.708-6. 045-5.913 1.00 0.00 O ATOM 1383 C1'CYT 14-21.939-7. 166-5.037 1.00 0.00 C ATOM 1384 N1 CYT 14-21.115-7. 076-3.813 1.00 0.00 N ATOM 1385 C6 CYT 14-20.759-5. 866-3.292 1.00 0.00 C ATOM 1386 C2 CYT 14-20.715-8. 265-3.220 1.00 0.00 C ATOM 1387 02 CYT 14-21.056-9. 344-3.702 1.00 0.00 0 ATOM 1388 N3 CYT 14-19.951-8. 201-2.097 1.00 0. 00 N ATOM 1389 C4 CYT 14-19.593-7. 021-1.576 1.00 0.00 C ATOM 1390 N4 CYT 14-18. 841-6. 995-0.477 1.00 0.00 N ATOM 1391 C5 CYT 14-20.004-5. 793-2.182 1.00 0.00 C ATOM 1392 C2'CYT 14-23. 427-7. 147-4.697 1.00 0.00 C ATOM 1393 02'CYT 14-24. 178-7. 981-5.588 1.00 0.00 O ATOM 1394 C3'CYT 14-23.770-5. 682-4.883 1.00 0.00 C ATOM 1395 03'CYT 14-25. 152-5. 576-5.237 1.00 0.00 0 ATOM 1396 1H5'CYT 14-22.016-3. 602-6.999 1.00 0.00 H ATOM 1397 2H5'CYT 14-23.635-3. 308-6.330 1.00 0.00 H ATOM 1398 H4'CYT 14-23. 421-5.658-6. 999 1.00 0.00 H ATOM 1399 H1'CYT 14-21.703-8. 090-5.566 1.00 0.00 H ATOM 1400 H6 CYT 14-21.095-4. 949-3.777 1.00 0.00 H ATOM 1401 1H4 CYT 14-18.563-6. 111-0.075 1.00 0.00 H ATOM 1402 2H4 CYT 14-18.555-7. 860-0.041 1.00 0.00 H ATOM 1403 H5 CYT 14-19.719-4. 832-1.758 1.00 0.00 H ATOM 1404 H2'CYT 14-23.580-7. 445-3. 656 1.00 0.00 H ATOM 1405 H02'CYT 14-25. 060-7. 608-5.651 1.00 0.00 H ATOM 1406 H3'CYT 14-23.511-5. 087-4.005 1.00 0.00 H ATOM 1407 P URI 15-26.266-5. 315-4.104 1.00 0.00 P ATOM 1408 01P URI 15-25.912-4. 072-3.383 1.00 0.00 0 ATOM 1409 02P URI 15-27.602-5. 451-4.728 1.00 0.00 0 ATOM 1410 05'URI 15-26.046-6. 558-3.103 1.00 0.00 0 ATOM 1411 C5'URI 15-26.511-7. 868-3.447 1.00 0.00 C ATOM 1412 C4'URI 15-25. 992-8. 922-2.472 1.00 0.00 C ATOM 1413 04'URI 15-24.558-8. 989-2.475 1.00 0.00 O ATOM 1414 C1'URI 15-24.077-9. 065-1.118 1.00 0.00 C ATOM 1415 N1 URI 15-23.406-7. 809-0.716 1.00 0.00 N ATOM 1416 C6 URI 15-23.852-6. 596-1.169 1.00 0.00 C ATOM 1417 C2 URI 15-22.326-7. 903 0.145 1.00 0.00 C ATOM 1418 02 URI 15-21.906-8. 982 0.556 1.00 0.00 0 ATOM 1419 N3 URI 15-21.738-6. 708 0.514 1.00 0.00 N ATOM 1420 C4 URI 15-22.127-5. 445 0.104 1.00 0.00 C ATOM 1421 04 URI 15-21. 527-4. 447 0.497 1.00 0.00 O ATOM 1422 C5 URI 15-23.260-5. 441-0.793 1.00 0.00 C ATOM 1423 C2'URI 15-25.309-9. 325-0.259 1.00 0.00 C ATOM 1424 02'URI 15-25.606-10. 724-0.167 1.00 0.00 O ATOM 1425 C3'URI 15-26. 368-8. 578-1.040 1.00 0.00 C ATOM 1426 03'URI 15-27.647-9. 152-0.752 1.00 0.00 O ATOM 1427 1H5'URI 15-26.170-8. 116-4.452 1.00 0.00 H ATOM 1428 2H5'URI 15-27. 601-7. 873-3.429 1.00 0.00 H ATOM 1429 H4'URI 15-26. 399-9. 897-2. 734 1.00 0.00 H ATOM 1430 H1'URI 15-23. 381-9. 900-1. 024 1.00 0.00 H ATOM 1431 H6 URI 15-24.700-6. 561-1.853 1.00 0.00 H ATOM 1432 H3 URI 15-20.950-6. 761 1.143 1.00 0.00 H ATOM 1433 H5 URI 15-23. 647-4. 495-1.167 1.00 0.00 H ATOM 1434 H2'URI 15-25. 180-8. 882 0.733 1.00 0.00 H ATOM 1435 H02'URI 15-25. 544-11. 088-1.053 1.00 0.00 H ATOM 1436 H3'URI 15-26. 334-7. 503-0.851 1.00 0.00 H ATOM 1437 P URI 16-28. 500-8. 652 0.517 1. 00 0.00 P

ATOM 1438 O1P URI 16-29.825-9. 308 0.471 1.00 0.00 0 ATOM 1439 02P URI 16-28.409-7. 176 0.586 1.00 0.00 O ATOM 1440 05'URI 16-27.676-9. 267 1.758 1.00 0.00 0 ATOM 1441 C5'URI 16-28.147-9. 098 3.099 1.00 0.00 C ATOM 1442 C4'URI 16-28. 416-10.439 3.770 1.00 0.00 C ATOM 1443 04'URI 16-29.275-11. 259 2.964 1.00 0.00 0 ATOM 1444 C1'URI 16-28.666-12. 536 2.757 1.00 0.00 C ATOM 1445 N1 URI 16-29.011-13. 081 1.425 1.00 0.00 N ATOM 1446 C6 URI 16-28.697-12. 396 0.280 1.00 0.00 C ATOM 1447 C2 URI 16-29.659-14. 304 1.379 1.00 0.00 C ATOM 1448 02 URI 16-29.948-14. 933 2.395 1.00 0.00 O ATOM 1449 N3 URI 16-29.966-14. 781 0.118 1.00 0.00 N ATOM 1450 C4 URI 16-29.686-14. 154-1.084 1.00 0.00 C ATOM 1451 04 URI 16-30.007-14. 673-2.151 1.00 0.00 O ATOM 1452 C5 URI 16-29.009-12. 885-0. 943 1.00 0.00 C ATOM 1453 C2'URI 16-27. 172-12.294 2.882 1.00 0.00 C ATOM 1454 02'URI 16-26.475-13. 481 3.277 1.00 0.00 0 ATOM 1455 C3'URI 16-27.119-11. 225 3.961 1.00 0.00 C ATOM 1456 03'URI 16-27.170-11. 857 5.242 1.00 0.00 O ATOM 1457 1H5'URI 16-29.060-8. 515 3.086 1.00 0.00 H ATOM 1458 2H5'URI 16-27.398-8. 561 3.677 1.00 0.00 H ATOM 1459 H4'URI 16-28. 885-10.272 4.738 1.00 0.00 H ATOM 1460 Hl'URI 16-28.991-13. 228 3.535 1.00 0.00 H ATOM 1461 H6 URI 16-28.186-11. 436 0.356 1. 00 0.00 H ATOM 1462 H3 URI 16-30.439-15. 671 0.069 1.00 0.00 H ATOM 1463 H5 URI 16-28. 745-12.315-1. 834 1.00 0.00 H ATOM 1464 H2'URI 16-26.774-11. 897 1.944 1.00 0.00 H ATOM 1465 H02'URI 16-25. 558-13. 239 3.421 1.00 0.00 H ATOM 1466 H3'URI 16-26.240-10. 589 3.857 1.00 0.00 H ATOM 1467 P CYT 17-26.857-11. 005 6.573 1.00 0.00 P ATOM 1468 01P CYT 17-27. 882-9.945 6.700 1.00 0.00 0 ATOM 1469 02P CYT 17-26.631-11. 951 7.688 1.00 0.00 0 ATOM 1470 05'CYT 17-25.451-10. 308 6.207 1.00 0.00 0 ATOM 1471 C5'CYT 17-24. 296-11.112 5.960 1.00 0.00 C ATOM 1472 C4'CYT 17-23.110-10. 284 5.482 1.00 0.00 C ATOM 1473 04'CYT 17-23.414-9. 586 4.264 1.00 0.00 0 ATOM 1474 C1'CYT 17-23.047-8. 215 4.414 1.00 0.00 C ATOM 1475 N1 CYT 17-23. 874-7.334 3.567 1.00 0.00 N ATOM 1476 C6 CYT 17-25.118-7. 717 3.179 1.00 0.00 C ATOM 1477 C2 CYT 17-23.338-6. 110 3.186 1.00 0.00 C ATOM 1478 02 CYT 17-22.207-5. 788 3.546 1.00 0.00 0 ATOM 1479 N3 CYT 17-24.096-5. 291 2.406 1.00 0.00 N ATOM 1480 C4 CYT 17-25.324-5. 657 2.017 1.00 0.00 C ATOM 1481 N4 CYT 17-26.040-4. 835 1.250 1.00 0.00 N ATOM 1482 C5 CYT 17-25.873-6. 916 2.410 1.00 0.00 C ATOM 1483 C2'CYT 17-23.253-7. 927 5.887 1.00 0. 00 C ATOM 1484 02'CYT 17-22.498-6. 789 6.318 1.00 0.00 0 ATOM 1485 C3'CYT 17-22.737-9. 216 6.509 1.00 0.00 C ATOM 1486 03'CYT 17-21.307-9. 143 6.577 1.00 0.00 0 ATOM 1487 1H5'CYT 17-24.535-11. 853 5.204 1.00 0. 00 H ATOM 1488 2H5'CYT 17-24.022-11. 621 6.879 1.00 0. 00 H ATOM 1489 H4'CYT 17-22.257-10. 939 5.316 1.00 0.00 H ATOM 1490 Hl'CYT 17-22. 000-8.090 4.158 1.00 0.00 H ATOM 1491 H6 CYT 17-25.502-8. 687 3.490 1.00 0.00 H ATOM 1492 1H4 CYT 17-26.967-5. 104 0.950 1.00 0.00 H ATOM 1493 2H4 CYT 17-25.658-3. 944 0.969 1. 00 0.00 H ATOM 1494 H5 CYT 17-26.871-7. 216 2.104 1.00 0.00 H ATOM 1495 H2'CYT 17-24.318-7. 805 6.105 1.00 0.00 H ATOM 1496 H02'CYT 17-21.586-6. 935 6.054 1.00 0. 00 H ATOM 1497 H3'CYT 17-23.188-9. 415 7.480 1.00 0.00 H

ATOM 1498 P GUA 18-20.507-9. 815 7.803 1.00 0.00 P ATOM 1499 O1P GUA 18-19.057-9. 633 7.564 1.00 0.00 0 ATOM 1500 02P GUA 18-21.110-9. 336 9.067 1.00 0.00 0 ATOM 1501 05'GUA 18-20.855-11. 380 7.641 1.00 0. 00 0 ATOM 1502 C5'GUA 18-20.186-12. 184 6.663 1.00 0.00 C ATOM 1503 C4'GUA 18-20.716-13. 617 6.662 1.00 0.00 C ATOM 1504 04'GUA 18-22.103-13. 663 6.308 1.00 0.00 0 ATOM 1505 C1'GUA 18-22.349-14. 801 5.459 1.00 0.00 C ATOM 1506 N9 GUA 18-22.798-14. 387 4.114 1.00 0.00 N ATOM 1507 C4 GUA 18-22.424-13. 249 3.429 1.00 0.00 C ATOM 1508 N3 GUA 18-21.574-12. 297 3.875 1.00 0.00 N ATOM 1509 C2 GUA 18-21.409-11. 312 2.987 1.00 0. 00 C ATOM 1510 N2 GUA 18-20.605-10. 287 3.269 1.00 0.00 N ATOM 1511 N1 GUA 18-22.036-11. 277 1.758 1.00 0.00 N ATOM 1512 C6 GUA 18-22.909-12. 241 1.277 1. 00 0.00 C ATOM 1513 06 GUA 18-23.407-12. 120 0. 161 1.00 0.00 0 ATOM 1514 C5 GUA 18-23. 092-13.292 2.215 1.00 0.00 C ATOM 1515 N7 GUA 18-23.882-14. 441 2.126 1.00 0.00 N ATOM 1516 C8 GUA 18-23.649-15. 009 3.261 1.00 0. 00 C ATOM 1517 C2'GUA 18-21.031-15. 570 5.385 1.00 0.00 C ATOM 1518 02'GUA 18-20.954-16. 578 6.400 1.00 0.00 0 ATOM 1519 C3'GUA 18-20.018-14. 466 5.614 1.00 0.00 C ATOM 1520 03'GUA 18-18.840-15. 039 6.194 1.00 0. 00 0 ATOM 1521 1H5'GUA 18-19.119-12. 200 6.885 1.00 0.00 H ATOM 1522 2H5'GUA 18-20. 338-11.747 5.677 1.00 0.00 H ATOM 1523 H4'GUA 18-20.580-14. 061 7.646 1.00 0.00 H ATOM 1524 H1'GUA 18-23.111-15. 433 5.917 1.00 0.00 H ATOM 1525 1H2 GUA 18-20. 481-9.543 2.598 1.00 0.00 H ATOM 1526 2H2 GUA 18-20. 122-10.254 4.155 1.00 0.00 H ATOM 1527 H1 GUA 18-21.862-10. 493 1.144 1.00 0.00 H ATOM 1528 H8 GUA 18-24. 121-15.955 3.526 1.00 0.00 H ATOM 1529 H2'GUA 18-20.903-16. 004 4.389 1.00 0.00 H ATOM 1530 H02'GUA 18-21.617-17. 241 6.195 1.00 0.00 H ATOM 1531 H3'GUA 18-19.811-13. 907 4.701 1.00 0.00 H ATOM 1532 P GUA 19-17.387-14. 764 5.554 1.00 0.00 P ATOM 1533 01P GUA 19-17.197-13. 300 5.449 1.00 0.00 0 ATOM 1534 02P GUA 19-16.395-15. 585 6.285 1. 00 0.00 0 ATOM 1535 05'GUA 19-17.536-15. 360 4.064 1.00 0.00 0 ATOM 1536 C5'GUA 19-17.856-16. 740 3.856 1.00 0.00 C ATOM 1537 C4'GUA 19-18.676-16. 941 2.582 1.00 0.00 C ATOM 1538 04'GUA 19-19.828-16. 080 2.558 1.00 0.00 0 ATOM 1539 C1'GUA 19-19.908-15. 423 1.279 1.00 0.00 C ATOM 1540 N9 GUA 19-19.489-14. 010 1.373 1.00 0.00 N ATOM 1541 C4 GUA 19-19. 761-13. 010 0.467 1.00 0.00 C ATOM 1542 N3 GUA 19-20.478-13. 144-0.672 1.00 0.00 N ATOM 1543 C2 GUA 19-20.571-11. 994-1.348 1.00 0.00 C ATOM 1544 N2 GUA 19-21.242-11. 951-2.498 1.00 0.00 N ATOM 1545 N1 GUA 19-20.000-10. 810-0. 926 1.00 0.00 N ATOM 1546 C6 GUA 19-19.262-10. 649 0.238 1.00 0.00 C ATOM 1547 06 GUA 19-18.799-9. 548 0.527 1.00 0.00 0 ATOM 1548 C5 GUA 19-19.156-11. 864 0.961 1.00 0.00 C ATOM 1549 N7 GUA 19-18.506-12. 132 2.168 1.00 0.00 N ATOM 1550 C8 GUA 19-18.751-13. 388 2.325 1.00 0.00 C ATOM 1551 C2'GUA 19-18.977-16. 203 0.367 1.00 0.00 C ATOM 1552 02'GUA 19-19.619-17. 363-0.175 1.00 0.00 0 ATOM 1553 C3'GUA 19-17.877-16. 572 1.340 1.00 0.00 C ATOM 1554 03'GUA 19-17.210-17. 743 0.856 1.00 0.00 0 ATOM 1555 1H5'GUA 19-18.429-17. 105 4.708 1.00 0.00 H ATOM 1556 2H5'GUA 19-16.932-17. 312 3.778 1. 00 0. 00 H ATOM 1557 H4'GUA 19-19.001-17. 978 2.515 1.00 0.00 H

ATOM 1558 H1'GUA 19-20.929-15. 480 0.900 1.00 0.00 H ATOM 1559 1H2 GUA 19-21.680-12. 786-2.859 1.00 0.00 H ATOM 1560 2H2 GUA 19-21. 311-11. 083-3.010 1.00 0.00 H ATOM 1561 Hl GUA 19-20.114-9. 984-1.495 1.00 0. 00 H ATOM 1562 H8 GUA 19-18.374-13. 932 3.189 1.00 0.00 H ATOM 1563 H2'GUA 19-18.590-15. 557-0.425 1.00 0.00 H ATOM 1564 H02'GUA 19-19.960-17. 872 0.564 1.00 0.00 H ATOM 1565 H3'GUA 19-17.193-15. 740 1.520 1. 00 0.00 H ATOM 1566 P ADE 20-15.950-17. 613-0.140 1.00 0.00 P ATOM 1567 O1P ADE 20-15. 576-18. 973-0.591 1.00 0.00 O ATOM 1568 02P ADE 20-14.937-16. 747 0.503 1.00 0.00 0 ATOM 1569 05'ADE 20-16. 572-16.817-1. 394 1.00 0.00 0 ATOM 1570 C5'ADE 20-17.473-17. 468-2.294 1.00 0.00 C ATOM 1571 C4'ADE 20-18.046-16. 496-3.323 1.00 0.00 C ATOM 1572 04'ADE 20-18.757-15. 418-2.704 1.00 0. 00 O ATOM 1573 C1'ADE 20--18. 509-14.200-3. 437 1.00 0.00 C ATOM 1574 N9 ADE 20-17.792-13. 209-2.609 1.00 0.00 N ATOM 1575 C4 ADE 20-17. 673-11.861-2. 861 1.00 0.00 C ATOM 1576 N3 ADE 20-18.179-11. 197-3.919 1.00 0.00 N ATOM 1577 C2 ADE 20-17.884-9. 902-3.865 1.00 0.00 C ATOM 1578 N1 ADE 20-17.186-9. 274-2.917 1.00 0.00 N ATOM 1579 C6 ADE 20-16.692-9. 957-1.870 1.00 0.00 C ATOM 1580 N6 ADE 20-16.013-9. 307-0.925 1.00 0.00 N ATOM 1581 C5 ADE 20-16. 939-11.333-1. 824 1.00 0.00 C ATOM 1582 N7 ADE 20-16. 585-12. 329-0.909 1.00 0.00 N ATOM 1583 C8 ADE 20-17.118-13. 376-1.444 1.00 0.00 C ATOM 1584 C2'ADE 20-17.675-14. 602-4. 650 1.00 0.00 C ATOM 1585 02'ADE 20-18.504-14. 928-5.772 1.00 0.00 0 ATOM 1586 C3'ADE 20-16. 947-15. 818-4.117 1.00 0.00 C ATOM 1587 03'ADE 20-16.583-16. 657-5.216 1.00 0.00 O ATOM 1588 1H5'ADE 20-18.293-17. 905-1.724 1.00 0.00 H ATOM 1589 2H5'ADE 20-16.940-18. 263-2.816 1.00 0. 00 H ATOM 1590 H4'ADE 20-18.714-17. 027-4.000 1.00 0.00 H ATOM 1591 H1'ADE 20-19.457-13. 778-3.771 1.00 0.00 H ATOM 1592 H2 ADE 20-18.253-9. 285-4.684 1.00 0.00 H ATOM 1593 1H6 ADE 20-15.648-9. 811-0.129 1.00 0.00 H ATOM 1594 2H6 ADE 20-15. 868-8. 310-1.002 1.00 0. 0. 0 H ATOM 1595 H8 ADE 20-17.023-14. 357-0.982 1.00 0.00 H ATOM 1596 H2'ADE 20-16.965-13. 810-4.900 1.00 0.00 H ATOM 1597 H02'ADE 20-19.110-15. 616-5.488 1.00 0. 00 H ATOM 1598 H3'ADE 20-16.095-15. 544-3.493 1. 00 0. 00 H ATOM 1599 P GUA 21-15.218-16. 387-6.026 1. 00 0.00 P ATOM 1600 O1P GUA 21-15.091-17. 422-7.077 1.00 0. 00 0 ATOM 1601 02P GUA 21-14.127-16. 193-5.046 1.00 0. 00 0 ATOM 1602 05'GUA 21-15.511-14. 973-6. 740 1.00 0.00 0 ATOM 1603 C5'GUA 21-16.362-14. 901-7.888 1.00 0.00 C ATOM 1604 C4'GUA 21-16.357-13. 507-8.508 1.00 0.00 C ATOM 1605 04'GUA 21-16. 916-12.525-7. 629 1.00 0.00 0 ATOM 1606 Cl'GUA 21-16.175-11. 293-7.758 1.00 0.00 C ATOM 1607 N9 GUA 21-15. 509-10. 938-6.488 1.00 0.00 N ATOM 1608 C4 GUA 21-15.117-9. 679-6. 090 1.00 0.00 C ATOM 1609 N3 GUA 21-15.222-8. 545-6.821 1.00 0.00 N ATOM 1610 C2 GUA 21-14.757-7. 477-6.165 1. 00'0. 00 C ATOM 1611 N2 GUA 21-14.766-6. 279-6.750 1.00 0.00 N ATOM 1612 N1 GUA 21-14. 236-7.529-4. 888 1.00 0.00 N ATOM 1613 C6 GUA 21-14.119-8. 679-4.119 1.00 0.00 C ATOM 1614 06 GUA 21-13.655-8. 615-2.983 1.00 0.00 0 ATOM 1615 C5 GUA 21-14.606-9. 820-4.809 1.00 0.00 C ATOM 1616 N7 GUA 21-14.666-11. 155-4.399 1.00 0.00 N ATOM 1617 C8 GUA 21-15.196-11. 722-5. 429 1.00 0.00 C

ATOM 1618 C2'GUA 21-15.157-11. 528-8.870 1.00 0.00 C ATOM 1619 02'GUA 21-15.683-11. 156-10.150 1.00 0.00 0 ATOM 1620 C3'GUA 21-14.944-13. 024-8.767 1.00 0.00 C ATOM 1621 03'GUA 21-14.510-13. 525-10.035 1.. 00 0.00 0 ATOM 1622 1H5'GUA 21-17.380-15. 157-7.595 1.00 0.00 H ATOM 1623 2H5'GUA 21-16.015-15. 620-8.631 1.00 0.00 H ATOM 1624 H4'GUA 21-16. 918-13.517-9. 441 1.00 0.00 H ATOM 1625 Hl'GUA 21-16.853-10. 490-8.049 1.00 0.00 H ATOM 1626 1H2 GUA 21-15.124-6. 178-7.689 1.00 0.00 H ATOM 1627 2H2 GUA 21-14.412-5. 472-6.255 1.00 0.00 H ATOM 1628 H1 GUA 21-13.912-6. 675-4.458 1.00 0.00 H ATOM 1629 H8 GUA 21-15.367-12. 796-5.455 1.00 0.00 H ATOM 1630 H2'GUA 21-14.230-10. 994-8.653 1.00 0.00 H ATOM 1631 H02'GUA 21-16.501-11. 641-10.274 1.00 0.00 H ATOM 1632 H3'GUA 21-14.264-13. 286-7.954 1.00 0.00 H ATOM 1633 P ADE 22-12.946-13. 531-10.419 1.00 0.00 P ATOM 1634 01P ADE 22-12.766-14. 376-11.620 1.00 0.00 0 ATOM 1635 02P ADE 22-12.168-13. 818-9.192 1.00 0.00 0 ATOM 1636 05'ADE 22-12.684-11. 998-10.834 1.00 0.00 0 ATOM 1637 C5'ADE 22-13.324-11. 442-11.986 1.00 0.00 C ATOM 1638 C4'ADE 22-13.187-9. 923-12.029 1.00 0.00 C ATOM 1639 04'ADE 22-13.722-9. 308-10.850 1.00 0.00 0 ATOM 1640 C1'ADE 22-12.871-8. 213-10.457 1.00 0.00 C ATOM 1641 N9 ADE 22-12.208-8. 477-9.165 1.00 0.00 N ATOM 1642 C4 ADE 22-11.597-7. 545-8.358 1.00 0.00 C ATOM 1643 N3 ADE 22-11.532-6. 217-8.579 1.00 0.00 N ATOM 1644 C2 ADE 22-10.870-5. 597-7.609 1.00 0.00 C ATOM 1645 N1 ADE 22-10.315-6. 152-6.531 1.00 0.00 N ATOM 1646 C6 ADE 22-10.393-7. 480-6.333 1.00 0.00 C ATOM 1647 N6 ADE 22-9.824-8. 016-5.254 1.00 0.00 N ATOM 1648 C5 ADE 22-11.071-8. 236-7.292 1.00 0.00 C ATOM 1649 N7 ADE 22-11.340-9. 603-7.403 1.00 0.00 N ATOM 1650 C8 ADE 22-11.999-9. 649-8.511 1.00 0.00 C ATOM 1651 C2'ADE 22-11.837-8. 067-11.569 1.00 0.00 C ATOM 1652 02'ADE 22-12.297-7. 188-12.603 1.00 0.00 0 ATOM 1653 C3'ADE 22-11.732-9. 496-12.054 1.00 0.00 C ATOM 1654 03'ADE 22-11.270-9. 494-13.408 1.00 0.00 0 ATOM 1655 1H5'ADE 22-14.382-11. 702-11.967 1.00 0.00 H ATOM 1656 2H5'ADE 22-12.870-11. 865-12. 883 1.00 0.00 H ATOM 1657 H4'ADE 22-13.701-9. 532-12.905 1.00 0.00 H ATOM 1658 H1'ADE 22-13.462-7. 299-10.386 1.00 0.00 H ATOM 1659 H2 ADE 22-10.772-4. 515-7.703 1.00 0.00 H ATOM 1660 1H6 ADE 22-9.873-9. 013-5.101 1.00 0.00 H ATOM 1661 2H6 ADE 22-9.344-7. 426-4.591 1.00 0.00 H ATOM 1662 H8 ADE 22-12.375-10. 593-8.904 1.00 0.00 H ATOM 1663 H2'ADE 22-10.881-7. 730-11.159 1.00 0. 00 H ATOM 1664 H02'ADE 22-13.138-7. 529-12.916 1.00 0.00 H ATOM 1665 H3'ADE 22-11.111-10. 107-11.396 1.00 0.00 H ATOM 1666 P CYT 23-9.692-9. 457-13.727 1.00 0.00 P ATOM 1667 01P CYT 23-9.015-10. 428-12.839 1.00 0.00 0 ATOM 1668 02P CYT 23-9.514-9. 550-15.194 1.00 0.00 0 ATOM 1669 05'CYT 23-9.274-7. 973-13.260 1.00 0.00 0 ATOM 1670 C5'CYT 23-9.654-6. 834-14.037 1.00 0.00 C ATOM 1671 C4'CYT 23-9.097-5. 538-13.453 1.00 0.00 C ATOM 1672 04'CYT 23-9.581-5. 292-12.132 1.00 0.00 0 ATOM 1673 C1'CYT 23-8.568-4. 587-11.385 1.00 0.00 C ATOM 1674 N1 CYT 23-8.219-5. 302-10.137 1.00 0.00 N ATOM 1675 C6 CYT 23-8.216-6. 666-10.081 1.00 0.00 C ATOM 1676 C2 CYT 23-7.878-4. 532-9.032 1.00 0.00 C ATOM 1677 02 CYT 23-7.890-3. 304-9.105 1. 00 0.00 0

ATOM 1678 N3 CYT 23-7.533-5. 171-7.882 1.00 0.00 N ATOM 1679 C4 CYT 23-7. 524-6.507-7. 813 1.00 0.00 C ATOM 1680 N4 CYT 23-7.178-7. 098-6.670 1.00 0.00 N ATOM 1681 C5 CYT 23-7.876-7. 305-8. 945 1.00 0.00 C ATOM 1682 C2'CYT 23-7.350-4. 473-12.307 1.00 0.00 C ATOM 1683 02'CYT 23-7.309-3. 201-12. 965 1.00 0.00 0 ATOM 1684 C3'CYT 23-7.593-5. 603-13.289 1.00 0.00 C ATOM 1685 03'CYT 23-6. 979-5. 277-14.539 1.00 0.00 0 ATOM 1686 1H5'CYT 23-10. 742-6.770-14. 068 1.00 0.00 H- ATOM 1687 2H5'CYT 23-9.276-6. 956-15.053 1.00 0.00 H ATOM 1688 H4'CYT 23-9.362-4. 699-14.096 1.00 0.00 H ATOM 1689 H1'CYT 23-8.931-3. 588-11.141 1.00 0.00 H ATOM 1690 H6 CYT 23-8.493-7. 244-10.963 1.00 0.00 H ATOM 1691 1H4 CYT 23-7. 165-8.106-6. 606 1.00 0.00 H ATOM 1692 2H4 CYT 23-6.927-6. 538-5.868 1.00 0.00 H ATOM 1693 H5 CYT 23-7.866-8. 393-8.892 1.00 0.00 H ATOM 1694 H2'CYT 23-6.431-4. 652-11.742 1.00 0.00 H ATOM 1695 H02'CYT 23-7.034-2. 551-12.314 1.00 0.00 H ATOM 1696 H3'CYT 23-7.264-6. 566-12.895 1.00 0.00 H ATOM 1697 P GUA 24-5.393-5. 472-14.749 1.00 0.00 P ATOM 1698 01P GUA 24-5.130-5. 611-16.198 1.00 0.00 0 ATOM 1699 02P GUA 24-4. 924-6. 517-13.811 1.00 0.00 0 ATOM 1700 05'GUA 24-4.799-4. 058-14.261 1.00 0.00 0 ATOM 1701 C5'GUA 24-5.067-2. 863-15.002 1.00 0.00 C ATOM 1702 C4'GUA 24-4.330-1. 661-14.418 1.00 0.00 C ATOM 1703 04'GUA 24-4.699-1. 429-13.049 1.00 0.00 O ATOM 1704 C1'GUA 24-3.512-1. 233-12. 261 1.00 0.00 C ATOM 1705 N9 GUA 24-3.218-2. 414-11. 428 1.00 0.00 N ATOM 1706 C4 GUA 24-2.314-2. 479-10.395 1.00 0.00 C ATOM 1707 N3 GUA 24-1.532-1. 463-9.966 1.00 0.00 N ATOM 1708 C2 GUA 24-0.753-1. 824-8. 944 1.00 0.00 C ATOM 1709 N2 GUA 24 0.082-0. 940-8. 399 1.00 0. 00 N ATOM 1710 N1 GUA 24-0.752-3. 090-8.394 1.00 0.00 N ATOM 1711 C6 GUA 24-1.545-4. 149-8.816 1.00 0.00 C ATOM 1712 06 GUA 24-1.468-5. 240-8.256 1.00 0.00 0 ATOM 1713 C5 GUA 24-2. 376-3.773-9. 904 1.00 0.00 C ATOM 1714 N7 GUA 24-3.312-4. 526-10.619 1.00 0.00 N ATOM 1715 C8 GUA 24-3.745-3. 663-11.474 1.00 0.00 C ATOM 1716 C2'GUA 24-2.398-0. 981-13.264 1.00 0.00 C ATOM 1717 02'GUA 24-2.361 0.391-13. 677 1.00 0.00 0 ATOM 1718 C3'GUA 24-2.825-1. 896-14.392 1.00 0.00 C ATOM 1719 03'GUA 24-2.260-1. 418-15.617 1.00 0.00 0 ATOM 1720 1H5'GUA 24-6.139-2. 666-14.983 1.00 0.00 H ATOM 1721 2H5'GUA 24-4.751-3. 007-16.036 1.00 0.00 H ATOM 1722 H4'GUA 24-4. 552-0.773-15. 007 1.00 0.00 H ATOM 1723 H1'GUA 24-3.632-0. 358-11.621 1.00 0.00 H ATOM 1724 1H2 GUA 24 0.125 0.002-8. 759 1.00 0.00 H ATOM 1725 2H2 GUA 24 0.671-1. 212-7. 625 1.00 0.00 H ATOM 1726 H1 GUA 24-0.134-3. 283-7.623 1.00 0. 00 H ATOM 1727 H8 GUA 24-4.504-3. 928-12.209 1.00 0.00 H ATOM 1728 H2'GUA 24-1.438-1. 298-12.853 1.00 0.00 H ATOM 1729 H02'GUA 24-3.239 0.617-13. 993 1.00 0.00 H ATOM 1730 H3'GUA 24-2. 575-2. 938-14.189 1. 00 0.00 H ATOM 1731 P ADE 25-0.799-1. 907-16.092 1.00 0.00 P ATOM 1732 OlP ADE 25-0.680-3. 355-15.808 1.00 0.00 0 ATOM 1733 02P ADE 25-0.565-1. 404-17. 464 1.00 0.00 0 ATOM 1734 05'ADE 25 0.182-1. 116-15.089 1.00 0.00 0 ATOM 1735 C5'ADE 25 0.239 0.314-15. 110 1.00 0.00 C ATOM 1736 C4'ADE 25 0.971 0.870-13. 892 1.00 0.00 C ATOM 1737 04'ADE 25 0.399 0.394-12. 667 1.00 0.00 0

ATOM 1738 C1'ADE 25 1.451 0.052-11. 745 1.00 0.00 C ATOM 1739 N9 ADE 25 1.507-1. 406-11.513 1.00 0.00 N ATOM 1740 C4 ADE 25 2.223-2. 057-10.533 1.00 0.00 C ATOM 1741 N3 ADE 25 3.017-1. 482-9.608 1.00 0.00 N ATOM 1742 C2 ADE 25 3.565-2. 392-8.808 1.00 0.00 C ATOM 1743 N1 ADE 25 3.396-3. 715-8.856 1.00 0.00 N ATOM 1744 C6 ADE 25 2.597-4. 264-9.788 1.00 0.00 C ATOM 1745 N6 ADE 25 2.432-5. 586-9.815 1.00 0.00 N ATOM 1746 C5 ADE 25 1.967-3. 399-10. 688 1.00 0.00 C ATOM 1747 N7 ADE 25 1.094-3. 618-11.758 1.00 0.00 N ATOM 1748 C8 ADE 25 0.884-2. 415-12.172 1.00 0.00 C ATOM 1749 C2'ADE 25 2.742 0.559-12. 380 1.00 0.00 C ATOM 1750 02'ADE 25 2.999 1.923-12. 026 1.00 0.00 0 ATOM 1751 C3'ADE 25 2.420 0.413-13. 853 1.00 0.00 C ATOM 1752 03'ADE 25 3. 210 1.346-14. 598 1.00 0.00 0 ATOM 1753 lH5'ADE 25-0.777 0.709-15. 123 1.00 0.00 H ATOM 1754 2H5'ADE 25 0.757 0.635-16. 013 1.00 0.00 H ATOM 1755 H4'ADE 25 0.932 1.958-13. 907 1.00 0.00 H ATOM 1756 H1'ADE 25 1.285 0.566-10. 798 1.00 0.00 H ATOM 1757 H2 ADE 25 4.225-2. 016-8.026 1.00 0.00 H ATOM 1758 1H6 ADE 25 1.828-6. 006-10.507 1.00 0.00 H ATOM 1759 2H6 ADE 25 2.912-6. 168-9.143 1.00 0.00 H ATOM 1760 H8 ADE 25 0.236-2. 217-13.025 1.00 0.00 H ATOM 1761 H2'ADE 25 3.580-0. 087-12.104 1.00 0.00 H ATOM 1762 H02'ADE 25 2.221 2.432-12. 265 1.00 0.00 H ATOM 1763 H3'ADE 25 2.542-0. 615-14.197 1.00 0.00 H ATOM 1764 P CYT 26 4.697 0.961-15. 082 1.00 0.00 P ATOM 1765 01P CYT 26 5.181 2.029-15. 986 1.00 0.00 O ATOM 1766 02P CYT 26 4.688-0. 446-15.541 1.00 0. 00 O ATOM 1767 05'CYT 26 5.538 1.038-13. 714 1.00 0.00 O ATOM 1768 C5'CYT 26 5.668 2.276-13. 008 1.00 0.00 C ATOM 1769 C4'CYT 26 6.300 2.073-11. 636 1.00 0.00 C ATOM 1770 04'CYT 26 5.516 1.194-10. 815 1.00 0.00 0 ATOM 1771 C1'CYT 26 6.386 0.256-10. 152 1.00 0.00 C ATOM 1772 N1 CYT 26 6.236-1. 106-10.709 1.00 0.00 N ATOM 1773 C6 CYT 26 5.920-1. 294-12.023 1.00 0.00 C ATOM 1774 C2 CYT 26 6.458-2. 179-9.856 1.00 0.00 C ATOM 1775 02 CYT 26 6.739-1. 985-8.675 1.00 0.00 O ATOM 1776 N3 CYT 26 6.356-3. 438-10.364 1.00 0.00 N ATOM 1777 C4 CYT 26 6.051-3. 636-11.653 1.00 0.00 C ATOM 1778 N4 CYT 26 5.960-4. 881-12. 119 1.00 0.00 N ATOM 1779 C5 CYT 26 5.821-2. 531-12.532 1.00 0.00 C ATOM 1780 C2'CYT 26 7.800 0.775-10. 381 1. 00 0.00 C ATOM 1781 02'CYT 26 8.175 1.742-9. 392 1.00 0.00 O ATOM 1782 C3'CYT 26 7.655 1.399-11. 753 1.00 0.00 C ATOM 1783 03'CYT 26 8.656 2.409-11. 915 1.00 0.00 O ATOM 1784 1H5'CYT 26 4.680 2.721-12. 883 1.00 0.00 H ATOM 1785 2H5'CYT 26 6.293 2.953-13. 591 1.00 0.00 H ATOM 1786 H4'CYT 26 6.409 3.034-11. 135 1.00 0.00 H ATOM 1787 H1'CYT 26 6.167 0.244-9. 085 1.00 0.00 H ATOM 1788 H6 CYT 26 5.735-0. 432-12.664 1.00 0.00 H ATOM 1789 1H4 CYT 26 5.729-5. 041-13.089 1.00 0.00 H ATOM 1790 2H4 CYT 26 6.120-5. 664-11.501 1.00 0.00 H ATOM 1791 H5 CYT 26 5.591-2. 685-13.583 1.00 0.00 H ATOM 1792 H2'CYT 26 8.507-0. 058-10.411 1.00 0.00 H ATOM 1793 H02'CYT 26 8.212 1.286-8. 547 1.00 0.00 H ATOM 1794 H3'CYT 26 7.675 0.648-12. 547 1.00 0.00 H ATOM 1795 P CYT 27 9.957 2.136-12. 823 1.00 0.00 P ATOM 1796 01P CYT 27 9.518 1.502-14. 086 1.00 0.00 O ATOM 1797 02P CYT 27 10.763 3.377-12. 862 1.00 0.00 O

ATOM 1798 05'CYT 27 10.760 1.038-11. 962 1.00 0.00 O ATOM 1799 C5'CYT 27 11. 173 1.328-10. 623 1.00 0.00 C ATOM 1800 C4'CYT 27 11.573 0.063-9. 868 1.00 0.00 C ATOM 1801 04'CYT 27 10.530-0. 919-9.884 1.00 0.00 O ATOM 1802 C1'CYT 27 11.120-2. 235-9.962 1. 00 0. 00 C ATOM 1803 N1 CYT 27 10.713-2. 952-11.193 1.00 0.00 N ATOM 1804 C6 CYT 27 10.015-2. 323-12.186 1.00 0.00 C ATOM 1805 C2 CYT 27 11.081-4. 287-11.301 1.00 0.00 C ATOM 1806 02 CYT 27 11.715-4. 829-10.399 1.00 0.00 0 ATOM 1807 N3 CYT 27 10.730-4. 965-12.426 1.00 0.00 N ATOM 1808 C4 CYT 27 10.047-4. 365-13.407 1.00 0.00 C ATOM 1809 N4 CYT 27 9.722-5. 065-14.494 1.00 0.00 N ATOM 1810 C5 CYT 27 9.663-2. 990-13.304 1.00 0.00 C ATOM 1811 C2'CYT 27 12.632-2. 023-9.938 1.00 0.00 C ATOM 1812 02'CYT 27 13.151-2. 081-8.604 1.00 0.00 0 ATOM 1813 C3'CYT 27 12.748-0. 633-10.526 1.00 0.00 C ATOM 1814 03'CYT 27 13.964-0. 035-10.062 1.00 0.00 0 ATOM 1815 1H5'CYT 27 10.351 1.811-10. 094 1.00 0.00 H ATOM 1816 2H5'CYT 27 12.024 2.008-10. 653 1.00 0.00 H ATOM 1817 H4'CYT 27 11.820 0.310-8. 837 1.00 0.00 H ATOM 1818 H1'CYT 27 10. 823-2. 816-9.088 1.00 0.00 H ATOM 1819 H6 CYT 27 9.746-1. 273-12.075 1.00 0.00 H ATOM 1820 1H4 CYT 27 9.207-4. 625-15.243 1.00 0.00 H ATOM 1821 2H4 CYT 27 9.994-6. 035-14.569 1.00 0.00 H ATOM 1822 H5 CYT 27 9.109-2. 499-14.105 1.00 0.00 H ATOM 1823 H2'CYT 27 13.126-2. 752-10.585 1.00 0.00 H ATOM 1824 H02'CYT 27 12.664-1. 440-8.080 1.00 0.00 H ATOM 1825 H3'CYT 27 12.666-0. 640-11.614 1.00 0.00 H ATOM 1826 P GUA 28 15.382-0. 468-10.695 1.00 0.00 P ATOM 1827 01P GUA 28 15.189-0. 713-12.142 1.00 0.00 0 ATOM 1828 02P GUA 28 16.406 0.500-10. 243 1.00 0.00 0 ATOM 1829 05'GUA 28 15. 673-1. 884-9.982 1.00 0.00 O ATOM 1830 C5'GUA 28 16. 182-1. 938-8. 644 1.00 0.00 C ATOM 1831 C4'GUA 28 16.813-3. 295-8.335 1.00 0.00 C ATOM 1832 04'GUA 28 15.846-4. 355-8.391 1.00 0.00 O ATOM 1833 C1'GUA 28 16.370-5. 445-9.172 1.00 0.00 C ATOM 1834 N9 GUA 28 15.717-5. 508-10.495 1.00 0.00 N ATOM 1835 C4 GUA 28 15.610-6. 614-11.312 1.00 0.00 C ATOM 1836 N3 GUA 28 16.111-7. 844-11.055 1.00 0.00 N ATOM 1837 C2 GUA 28 15.844-8. 712-12.036 1.00 0.00 C ATOM 1838 N2 GUA 28 16.273-9. 971-11.948 1.00 0.00 N ATOM 1839 N1 GUA 28 15.138-8. 385-13.177 1.00 0.00 N ATOM 1840 C6 GUA 28 14.615-7. 132-13.462 1.00 0.00 C ATOM 1841 06 GUA 28 13.996-6. 944-14.506 1.00 0.00 0 ATOM 1842 C5 GUA 28 14. 894-6. 203-12. 426 1.00 0.00 C ATOM 1843 N7 GUA 28 14.552-4. 852-12.322 1.00 0.00 N ATOM 1844 C8 GUA 28 15.067-4. 538-11.182 1.00 0.00 C ATOM 1845 C2'GUA 28 17.861-5. 171-9.305 1. 00 0.00 C ATOM 1846 02'GUA 28 18.589-5. 659-8.171 1.00 0.00 O ATOM 1847 C3'GUA 28 17.869-3. 658-9.368 1.00 0.00 C ATOM 1848 03'GUA 28 19.139-3. 182-8.913 1.00 0.00 O ATOM 1849 1H5'GUA 28 15.366-1. 757-7.944 1.00 0.00 H ATOM 1850 2H5'GUA 28 16.937-1. 160-8.520 1.00 0.00 H ATOM 1851 H4'GUA 28 17.264-3. 271-7.344 1.00 0.00 H ATOM 1852 H1'GUA 28 16.215-6. 384-8. 640 1.00 0. 00 H ATOM 1853 1H2 GUA 28 16.799-10. 269-11.140 1.00 0.00 H ATOM 1854 2H2 GUA 28 16.069-10. 627-12. 689 1.00 0. 00 H ATOM 1855 H1 GUA 28 14.972-9. 101-13.869 1.00 0.00 H ATOM 1856 H8 GUA 28 14.987-3. 525-10.788 1.00 0.00 H ATOM 1857 H2'GUA 28 18.244-5. 597-10. 235 1.00 0.00 H

ATOM 1858 H02'GUA 28 18.189-5. 275-7.388 1.00 0.00 H ATOM 1859 H3'GUA 28 17.614-3. 290-10. 364 1.00 0.00 H ATOM 1860 P CYT 29 20.303-2. 830-9.968 1.00 0.00 P ATOM 1861 01P CYT 29 19.712-2. 020-11.057 1.00 0.00 0 ATOM 1862 02P CYT 29 21.470-2. 316-9.216 1.00 0.00 0 ATOM 1863 05'CYT 29 20.682-4. 276-10.566 1.00 0.00 0 ATOM 1864 C5'CYT 29 21.412-5. 222-9.779 1.00 0.00 C ATOM 1865 C4'CYT 29 21.458-6. 593-10.448 1.00 0.00 C ATOM 1866 04'CYT 29 20.144-7. 137-10.628 1.00 0.00 0 ATOM 1867 C1'CYT 29 20.044-7. 738-11.933 1.00 0.00 C ATOM 1868 N1 CYT 29 19.115-6. 982-12.805 1.00 0.00 N ATOM 1869 C6 CYT 29 18.941-5. 636-12.648 1.00 0.00 C ATOM 1870 C2 CYT 29 18.421-7. 692-13.777 1.00 0.00 C ATOM 1871 02 CYT 29 18.597-8. 903-13.905 1.00 0.00 0 ATOM 1872 N3 CYT 29 17.554-7. 012-14.576 1.00 0.00 N ATOM 1873 C4 CYT 29 17.373-5. 693-14.431 1.00 0.00 C ATOM 1874 N4 CYT 29 16.510-5. 061-15.225 1.00 0.00 N ATOM 1875 C5 CYT 29 18.086-4. 957-13.434 1.00 0.00 C ATOM 1876 C2'CYT 29 21.459-7. 739-12.502 1.00 0.00 C ATOM 1877 02'CYT 29 22.174-8. 925-12.133 1.00 0.00 0 ATOM 1878 C3'CYT 29 22.043-6. 505-11.847 1.00 0.00 C ATOM 1879 03'CYT 29 23.464-6. 655-11.761 1.00 0.00 0 ATOM 1880 1H5'CYT 29 20.935-5. 318-8.804 1.00 0.00 H ATOM 1881 2H5'CYT 29 22.431-4. 859-9. 642 1.00 0.00 H ATOM 1882 H4'CYT 29 22.053-7. 277-9.844 1.00 0.00 H ATOM 1883 H1'CYT 29 19.694-8. 766-11.832 1.00 0.00 H ATOM 1884 H6 CYT 29 19.503-5. 105-11.879 1.00 0.00 H ATOM 1885 1H4 CYT 29 16.362-4. 068-15.121 1.00 0.00 H ATOM 1886 2H4 CYT 29 16.004-5. 576-15.933 1.00 0.00 H ATOM 1887 H5 CYT 29 17.941-3. 883-13.315 1.00 0.00 H ATOM 1888 H2'CYT 29 21.430-7. 619-13.587 1.00 0.00 H ATOM 1889 H02'CYT 29 21.866-9. 632-12.704 1.00 0.00 H ATOM 1890 H3'CYT 29 21.747-5. 589-12.361 1.00 0.00 H ATOM 1891 P CYT 30 24.419-6. 084-12.925 1.00 0.00 P ATOM 1892 O1P CYT 30 23.956-4. 723-13.279 1.00 0.00 0 ATOM 1893 02P CYT 30 25.826-6. 302-12.518 1.00 0.00 O ATOM 1894 05'CYT 30 24.093-7. 064-14.161 1.00 0.00 0 ATOM 1895 C5'CYT 30 24.527-8. 427-14.145 1.00 0.00 C ATOM 1896 C4'CYT 30 23.795-9. 260-15. 195 1.00 0.00 C ATOM 1897 04'CYT 30 22.378-9. 216-15.007 1.00 0.00 0 ATOM 1898 C1'CYT 30 21.729-9. 178-16.290 1.00 0.00 C ATOM 1899 N1 CYT 30 20.970-7. 921-16.478 1.00 0.00 N ATOM 1900 C6 CYT 30 21.370-6. 756-15.885 1.00 0.00 C ATOM 1901 C2 CYT 30 19.837-7. 973-17.275 1.00 0.00 C ATOM 1902 02 CYT 30 19.501-9. 030-17.807 1.00 0.00 0 ATOM 1903 N3 CYT 30 19.121-6. 831-17.457 1.00 0.00 N ATOM 1904 C4 CYT 30 19.499-5. 682-16 883 1 : 00 0.00 C ATOM 1905 N4 CYT 30 18.773-4. 583-17.085 1.00 0.00 N ATOM 1906 C5 CYT 30 20.667-5. 621-16.059 1.00 0.00 C ATOM 1907 C2'CYT 30 22.841-9. 315-17.328 1.00 0.00 C ATOM 1908 02'CYT 30 23.074-10. 688-17. 665 1.00 0.00 0 ATOM 1909 C3'CYT 30 24.020-8. 712-16.593 1.00 0.00 C ATOM 1910 03'CYT 30 25.271-9. 142-17. 143 1. 00 0.00 0 ATOM 1911 1H5'CYT 30 24.335-8. 852-13.160 1.00 0. 00 H ATOM 1912 2H5'CYT 30 25.598-8. 462-14.346 1.00 0.00 H ATOM 1913 H4'CYT 30 24.134-10. 293-15.147 1.00 0.00 H ATOM 1914 H1'CYT 30 21.050-10. 028-16.375 1.00 0.00 H ATOM 1915 H6 CYT 30 22.267-6. 744-15. 267 1.00 0.00 H ATOM 1916 1H4 CYT 30 19. 048-3. 710-16.657 1. 00 0.00 H ATOM 1917 2H4 CYT 30 17. 953-4. 621-17.674 1.00 0.00 H

ATOM 1918 H5 CYT 30 20.977-4. 687-15.589 1.00 0.00 H ATOM 1919 H2'CYT 30 22.604-8. 726-18.219 1.00 0.00 H ATOM 1920 H02'CYT 30 22.292-11. 006-18.122 1.00 0.00 H ATOM 1921 H3'CYT 30 23.942-7. 621-16.590 1.00 0.00 H ATOM 1922 H03'CYT 30 25.964-8. 816-16.565 1.00 0.00 H TER ATOM 1923 05'GUA 1-9.413 4.825 19.728 1.00 0.00 0 ATOM 1924 C5'GUA 1-8.783 3.566 19.979 1.00 0.00 C ATOM 1925 C4'GUA 1-9.082 2.556 18.874 1.00 0.00 C ATOM 1926 04'GUA 1-10.494 2.325 18.741 1.00 0.00 O ATOM 1927 C1'GUA 1-10.863 2.394 17.351 1.00 0.00 C ATOM 1928 N9 GUA 1-11.582 3.648 17.050 1.00 0.00 N ATOM 1929 C4 GUA 1-12.451 3.868 16.004 1.00 0.00 C ATOM 1930 N3 GUA 1-12.808 2.963 15.064 1.00 0.00 N ATOM 1931 C2 GUA 1-13.669 3.470 14.176 1.00 0.00 C ATOM 1932 N2 GUA 1-14.122 2.712 13.178 1.00 0.00 N ATOM 1933 N1 GUA 1-14.137 4.769 14.219 1.00 0.00 N ATOM 1934 C6 GUA 1-13.786 5.715 15.172 1.00 0.00 C ATOM 1935 06 GUA 1-14.258 6.848 15.120 1.00 0.00 0 ATOM 1936 C5 GUA 1-12. 871 5.185 16.120 1.00 0.00 C ATOM 1937 N7 GUA 1-12.276 5.796 17.227 1.00 0.00 N ATOM 1938 C8 GUA 1-11.552 4.839 17.699 1.00 0.00 C ATOM 1939 C2'GUA 1-9.554 2.318 16.581 1.00 0.00 C ATOM 1940 02'GUA 1-9.128 0.962 16.396 1.00 0.00 0 ATOM 1941 C3'GUA 1-8.634 3.075 17.515 1.00 0.00 C ATOM 1942 03'GUA 1-7.286 2.654 17.279 1.00 0.00 0 ATOM 1943 H5'GUA 1-9.017 5.189 18.933 1.00 0.00 H ATOM 1944 1H5'GUA 1-9.144 3.171 20.929 1.00 0.00 H ATOM 1945 2H5'GUA 1-7.705 3.714 20.043 1.00 0.00 H ATOM 1946 H4'GUA 1-8.581 1.614 19.091 1.00 0.00 H ATOM 1947 H1'GUA 1-11.490 1.539 17.095 1.00 0.00 H ATOM 1948 1H2 GUA 1-13.815 1.754 13.093 1.00 0.00 H ATOM 1949 2H2 GUA 1-14.774 3.095 12.508 1.00 0.00 H ATOM 1950 H1 GUA 1-14.787 5.075 13.511 1.00 0.00 H ATOM 1951 H8 GUA 1-10.937 4.982 18.586 1.00 0.00 H ATOM 1952 H2'GUA 1-9.645 2.839 15.625 1.00 0.00 H ATOM 1953 H02'GUA 1-9.660 0.591 15.688 1.00 0.00 H ATOM 1954 H3'GUA 1-8.760 4.155 17.424 1.00 0.00 H ATOM 1955 P GUA 2-6.380 3.399 16.175 1.00 0.00 P ATOM 1956 O1P GUA 2-6.479 4.858 16.401 1.00 0.00 O ATOM 1957 02P GUA 2-5.053 2.745 16.146 1.00 0.00 0 ATOM 1958 05'GUA 2-7.145 3.050 14.801 1.00 0.00 O ATOM 1959 C5'GUA 2-7.159 1.711 14.299 1.00 0.00 C ATOM 1960 C4'GUA 2-8.181 1.539 13.178 1.00 0.00 C ATOM 1961 04'GUA 2-9.504 1.884 13.605 1.00 0.00 0 ATOM 1962 C1'GUA 2-10.192 2.556 12.530 1.00 0.00 C ATOM 1963 N9 GUA 2-10.517 3.953 12.885 1.00 0.00 N ATOM 1964 C4 GUA 2-11.478 4.744 12.295 1.00 0.00 C ATOM 1965 N3 GUA 2-12.299 4.375 11.286 1.00 0.00 N ATOM 1966 C2 GUA 2-13.127 5.359 10.923 1.00 0.00 C ATOM 1967 N2 GUA 2-14.001 5.165 9.935 1.00 0.00 N ATOM 1968 N1 GUA 2-13.139 6. 607 11.514 1.00 0.00 N ATOM 1969 C6 GUA 2-12.306 7.009 12.550 1.00 0.00 C ATOM 1970 06 GUA 2-12.398 8.144 13.009 1.00 0.00 0 ATOM 1971 C5 GUA 2-11.422 5.969 12.942 1.00 0.00 C ATOM 1972 N7 GUA 2-10. 436 5.959 13.933 1.00 0.00 N ATOM 1973 C8 GUA 2-9.969 4.761 13.828 1.00 0.00 C ATOM 1974 C2'GUA 2-9.248 2. 505 11.332 1.00 0.00 C ATOM 1975 02'GUA 2-9.464 1.328 10.543 1.00 0.00 O ATOM 1976 C3'GUA 2-7.900 2.478 12.021 1.00 0.00 C

ATOM 1977 03'GUA 2-6.944 1.867 11.148 1.00 0.00 O ATOM 1978 1H5'GUA 2-7. 407 1.028 15.112 1.00 0.00 H ATOM 1979 2H5'GUA 2-6.168 1.465 13.918 1.00 0.00 H ATOM 1980 H4'GUA 2-8.172 0.509 12.827 1.00 0.00 H ATOM 1981 Hl'GUA 2-11.109 2.016 12.293 1.00 0.00 H ATOM 1982 1H2 GUA 2-14.037 4.274 9.461 1.00 0.00 H ATOM 1983 2H2 GUA 2-14.625 5.910 9.659 1.00 0.00 H ATOM 1984 H1 GUA 2-13.797 7.298 11.182 1.00 0.00 H ATOM 1985 H8 GUA 2-9.162 4.412 14.472 1.00 0.00 H ATOM 1986 H2'GUA 2-9.353 3. 409 10.728 1.00 0.00 H ATOM 1987 H02'GUA 2-10.302 1.439 10. 088 1.00 0.00 H ATOM 1988 H3'GUA 2-7.593 3.470 12.358 1.00 0.00 H ATOM 1989 P CYT 3-6.113 2. 759 10.096 1.00 0.00 P ATOM 1990 01P CYT 3-5.204 1. 864 9.346 1.00 0.00 0 ATOM 1991 02P CYT 3-5.566 3.933 10.813 1.00 0.00 0 ATOM 1992 05'CYT 3-7.260 3.274 9.089 1.00 0.00 0 ATOM 1993 C5'CYT 3-7.910 2.360 8.202 1.00 0.00 C ATOM 1994 C4'CYT 3-9.148 2.978 7.558 1.00 0.00 C ATOM 1995 04'CYT 3-10.109 3.401 8.538 1.00 0.00 0 ATOM 1996 Cl'CYT 3-10.653 4.679 8. 145 1.00 0.00 C ATOM 1997 N1 CYT 3-10.188 5.765 9.034 1.00 0.00 N ATOM 1998 C6 CYT 3-8.983 5.685 9.668 1.00 0.00 C ATOM 1999 C2 CYT 3-11.009 6.875 9.177 1.00 0.00 C ATOM 2000 02 CYT 3-12.088 6.926 8.591 1.00 0.00 0 ATOM 2001 N3 CYT 3-10.583 7. 894 9. 971 1.00 0.00 N ATOM 2002 C4 CYT 3-9.402 7.829 10.598 1.00 0.00 C ATOM 2003 N4 CYT 3-9.015 8.846 11.366 1.00 0.00 N ATOM 2004 C5 CYT 3-8.553 6.686 10.453 1.00 0.00 C ATOM 2005 C2'CYT 3-10.163 4.907 6.722 1.00 0.00 C ATOM 2006 02'CYT 3-11.017 4.272 5.763 1.00 0.00 0 ATOM 2007 C3'CYT 3-8.807 4.243 6.792 1.00 0.00 C ATOM 2008 03'CYT 3-8.393 3.892 5.468 1.00 0.00 0 ATOM 2009 1H5'CYT 3-8.207 1.472 8.760 1.00 0.00 H ATOM 2010 2. H5' CYT 3-7.211 2.069 7.418 1.00 0.00 H ATOM 2011 H4'CYT 3-9.613 2.257 6.888 1.00 0.00 H ATOM 2012 H1'CYT 3-11.743 4.633 8.156 1.00 0.00 H ATOM 2013 H6 CYT 3-8. 361 4. 800 9.536 1.00 0.00 H ATOM 2014 1H4 CYT 3-8.126 8.808 11.845 1.00 0.00 H ATOM 2015 2H4 CYT 3-9.607 9.658 11.464 1.00 0.00 H ATOM 2016 H5 CYT 3-7.587 6.632 10.951 1.00 0.00 H ATOM 2017 H2'CYT 3-10.061 5.977 6.519 1.00 0.00 H ATOM 2018 H02'CYT 3-10.453 3.786 5.156 1.00 0.00 H ATOM 2019 H3'CYT 3-8.074 4.862 7.319 1.00 0.00 H ATOM 2020 P GUA 4-7.565 4.940 4.567 1.00 0.00 P ATOM 2021 01P GUA 4-7.293 4.309 3.256 1.00 0.00 0 ATOM 2022 02P GUA 4-6. 445 5.467 5.378 1.00 0.00 0 ATOM 2023 05'GUA 4-8.628 6.130 4.344 1.00 0.00 0 ATOM 2024 C5'GUA 4-9.822 5.905 3. 589 1.00 0.00 C ATOM 2025 C4'GUA 4-10.781 7.090 3.675 1.00 0.00 C ATOM 2026 04'GUA 4-11.100 7.429 5.026 1.00 0.00 0 ATOM 2027 Cl'GUA 4-11.327 8.851 5.111 1.00 0.00 C ATOM 2028 N9 GUA 4-10.438 9.489 6.104 1.00 0.00 N ATOM 2029 C4 GUA 4-10.391 10. 829 6.410 1.00 0.00 C ATOM 2030 N3 GUA 4-11.157 11.791 5.852 1.00 0.00 N ATOM 2031 C2 GUA 4-10.889 13.001 6.345 1.00 0.00 C ATOM 2032 N2 GUA 4-11.558 14. 061 5.895 1.00 0. 00 N ATOM 2033 N1 GUA 4-9.935 13.240 7.317 1.00 0.00 N ATOM 2034 C6 GUA 4-9.135 12.268 7.. 906 1.00 0.00 C ATOM 2035 06 GUA 4-8.314 12.584 8.765 1.00 0. 00 0 ATOM 2036 C5 GUA 4-9.416 10.975 7.384 1.00 0. 00 C

ATOM 2037 N7 GUA 4-8. 846 9.736 7.697 1.00 0.00 N ATOM 2038 C8 GUA 4-9.496 8.941 6.912 1.00 0. 00 C ATOM 2039 C2'GUA 4-11.066 9.413 3.712 1.00 0.00 C ATOM 2040 02'GUA 4-12.281 9. 544 2.964 1. 00 0.00 O ATOM 2041 C3'GUA 4-10.158 8.353 3.120 1.00 0.00 C ATOM 2042 03'GUA 4-10.309 8.358 1.697 1.00 0.00 0 ATOM 2043 1H5'GUA 4-10.323 5.016 3.973 1.00 0.00 H ATOM 2044 2H5'GUA 4-9.556 5.738 2.545 1.00 0.00 H ATOM 2045 H4'GUA 4-11.698 6.863 3.134 1.00 0.00 H ATOM 2046 H1'GUA 4-12.366 9.035 5.384 1.00 0.00 H ATOM 2047 1H2 GUA 4-12.265 13.946 5.183 1.00 0.00 H ATOM 2048 2H2 GUA 4-11.358 14.978 6.263 1.00 0.00 H ATOM 2049 H1 GUA 4-9.790 14.186 7.637 1.00 0.00 H ATOM 2050 H8 GUA 4-9.289 7.872 6.894 1.00 0.00 H ATOM 2051 H2'GUA 4-10.541 10.369 3.779 1.00 0.00 H ATOM 2052 H02'GUA 4-12.650 8.663 2.862 1.00 0.00 H ATOM 2053 H3'GUA 4-9.122 8.477 3.437 1.00 0.00 H ATOM 2054 P CYT 5-9.537 9.450 0.800 1.00 0.00 P ATOM 2055 01P CYT 5-8.148 9.563 1.300 1.00 0.00 0 ATOM 2056 02P CYT 5-9.784 9.137-0. 626 1.00 0.00 0 ATOM 2057 05'CYT 5-10.313 10.815 1.162 1. 00 0.00 0 ATOM 2058 C5'CYT 5-11.458 11.227 0.407 1.00 0.00 C ATOM 2059 C4'CYT 5-11.594 12.746 0.383 1.00 0.00 C ATOM 2060 04'CYT 5-11.873 13.277 1.684 1.00 0.00 0 ATOM 2061 C1'CYT 5-11.107 14.481 1.888 1.00 0.00 C ATOM 2062 N1 CYT 5-10.093 14. 299 2.950 1.00 0.00 N ATOM 2063 C6 CYT 5-9.497 13.087 3.150 1.00 0.00 C ATOM 2064 C2 CYT 5-9.768 15.404 3.727 1.00 0.00 C ATOM 2065 02 CYT 5-10.318 16.486 3.528 1.00 0.00 0 ATOM 2066 N3 CYT 5-8.833 15.251 4.704 1.00 0.00 N ATOM 2067 C4 CYT 5-8.241 14.069 4.912 1.00 0.00 C ATOM 2068 N4 CYT 5-7.337 13.954 5.883 1. 00 0.00 N ATOM 2069 C5 CYT 5-8. 571 12.929 4.113 1.00 0. 00 C ATOM 2070 C2'CYT 5-10.447 14.792 0.548 1.00 0.00 C ATOM 2071 02'CYT 5-11.279 15.624-0. 270 1.00 0.00 0 ATOM 2072 C3'CYT 5-10.292 13. 404-0. 037 1.00 0.00 C ATOM 2073 03'CYT 5-10.264 13.499-1. 465 1.00 0.00 O ATOM 2074 1H5'CYT 5-12.355 10.795 0. 852 1.00 0.00 H ATOM 2075 2H5'CYT 5-11.358 10.864-0. 617 1.00 0.00 H ATOM 2076 H4'CYT 5-12.389 13.035-0. 304 1.00 0.00 H ATOM 2077 Hl'CYT 5-11.778 15.297 2. 160 1. 00 0.00 H ATOM 2078 H6 CYT 5-9.777 12.237 2. 528 1. 00 0.00 H ATOM 2079 1H4 CYT 5-7.101 14.755 6.450 1. 00 0.00 H ATOM 2080 2H4 CYT 5-6.887 13.065 6.052 1.00 0.00 H ATOM 2081 H5 CYT 5-8.087 11.968 4.276 1.00 0.00 H ATOM 2082 H2'CYT 5-9.467 15.250 0.708 1.00 0.00 H ATOM 2083 H02'CYT 5-11.318 16.488 0.148 1.00 0.00 H ATOM 2084 H3'CYT 5-9.421 12.886 0. 367 1.00 0.00 H ATOM 2085 P URI 6-8.859 13.540-2. 251 1.00 0.00 P ATOM 2086 01P URI 6-7.931 12.591-1. 594 1.00 0.00 0 ATOM 2087 02P URI 6-9.135 13.417-3. 700 1.00 0.00 0 ATOM 2088 05'URI 6-8.339 15.035-1. 959 1.00 0.00 0 ATOM 2089 C5'URI 6-8.955 16.154-2. 603 1.00 0. 00 C ATOM 2090 C4'URI 6-8.518 17.476-1. 979 1.00 0.00 C ATOM 2091 04'URI 6-8.852 17. 541-0. 587 1. 00 0.00 O ATOM 2092 C1'URI 6-7.776 18.177 0.134 1.00 0.00 C ATOM 2093 N1 URI 6-7.129 17.240 1.081 1.00 0.00 N ATOM 2094 C6 URI 6-6.986 15.911 0.779 1.00 0.00 C ATOM 2095 C2 URI 6-6. 673 17.760 2.281 1.00 0.00 C ATOM 2096 02 URI 6-6.789 18.950 2.568 1.00 0. 00 O

ATOM 2097 N3 URI 6-6.074 16.861 3.144 1.00 0.00 N ATOM 2098 C4 URI 6-5.891 15.509 2.918 1.00 0.00 C ATOM 2099 04 URI 6-5.345 14.801 3.761 1.00 0.00 O ATOM 2100 C5 URI 6-6.394 15.051 1.643 1.00 0.00 C ATOM 2101 C2'URI 6-6.791 18.660-0. 925 1.00 0.00 C ATOM 2102 02'URI 6-7.102 19.988-1. 365 1.00 0.00 O ATOM 2103 C3'URI 6-7.009 17.641-2. 023 1.00 0.00 C ATOM 2104 03'URI 6-6. 644 18.226-3. 277 1.00 0.00 O ATOM 2105 1H5'URI 6-10.038 16.062-2. 518 1.00 0.00 H ATOM 2106 2H5'URI 6-8.679 16.152-3. 658 1.00 0.00 H ATOM 2107 H4'URI 6-8.994 18.304-2. 502 1.00 0.00 H ATOM 2108 Hl'URI 6-8.164 19.036 0.680 1.00 0.00 H ATOM 2109 H6 URI 6-7.359 15.536-0. 174 1.00 0.00 H ATOM 2110 H3 URI 6-5.737 17.228 4.023 1.00 0.00 H ATOM 2111 H5 URI 6-6.290 14.000 1.370 1.00 0.00 H ATOM 2112 H2'URI 6-5.771 18.601-0. 544 1.00 0.00 H ATOM 2113 H02'URI 6-8.024 19.991-1. 633 1.00 0.00 H ATOM 2114 H3'URI 6-6.485 16.705-1. 824 1.00 0.00 H ATOM 2115 P CYT 7-5. 146 18.065-3. 853 1.00 0.00 P ATOM 2116 01P CYT 7-5.124 18.589-5. 237 1.00 0.00 O ATOM 2117 02P CYT 7-4.691 16.683-3. 580 1.00 0.00 0 ATOM 2118 05'CYT 7-4.298 19. 066-2. 919 1.00 0.00 0 ATOM 2119 C5'CYT 7-4.490 20.481-3. 007 1.00 0.00 C ATOM 2120 C4'CYT 7-3.936 21.205-1. 782 1.00 0.00 C ATOM 2121 04'CYT 7-4.485 20.680-0. 568 1.00 0.00 O ATOM 2122 C1'CYT 7-3.466 20.672 0.452 1.00 0.00 C ATOM 2123 N1 CYT 7-3.153 19.300 0.906 1.00 0.00 N ATOM 2124 C6 CYT 7-3.441 18.211 0.133 1.00 0.00 C ATOM 2125 C2 CYT 7-2.536 19.167 2.141 1.00 0.00 C ATOM 2126 02 CYT 7-2.287 20.162 2.818 1.00 0.00 0 ATOM 2127 N3 CYT 7-2. 218 17.919 2. 573 1.00 0.00 N ATOM 2128 C4 CYT 7-2.492 16.842 1.828 1.00 0.00 C ATOM 2129 N4 CYT 7-2.161 15.636 2.286 1.00 0.00 N ATOM 2130 C5 CYT 7-3.130 16.970 0.554 1.00 0.00 C ATOM 2131 C2'CYT 7-2.237 21. 325-0. 172 1.00 0.00 C ATOM 2132 02'CYT 7-2.220 22.738 0.063 1.00 0.00 0 ATOM 2133 C3'CYT 7-2.438 21.005-1. 639 1.00 0.00 C ATOM 2134 03'CYT 7-1.758 21.994-2. 420 1.00 0.00 O ATOM 2135 1H5'CYT 7-5.557 20.690-3. 089 1.00 0.00 H ATOM 2136 2H5'CYT 7-3.985 20.854-3. 899 1.00 0.00 H ATOM 2137 H4'CYT 7-4.160 22. 268-1.849 1. 00 0.00 H ATOM 2138 H1'CYT 7-3.800 21.267 1.302 1.00 0.00 H ATOM 2139 H6 CYT 7-3.927 18.348-0. 833 1.00 0.00 H ATOM 2140 1H4 CYT 7-2.361 14.814 1.736 1.00 0.00 H ATOM 2141 2H4 CYT 7-1.706 15. 547 3.184 1.00 0.00 H ATOM 2142 H5 CYT 7-3.356 16.095-0. 055 1.00 0.00 H ATOM 2143 H2'CYT 7-1.325 20.851 0.201 1.00 0.00 H ATOM 2144 H02'CYT 7-3. 043 23. 094-0. 279 1.00 0.00 H ATOM 2145 H3'CYT 7-2.131 19.986-1. 883 1.00 0.00 H ATOM 2146 P ADE 8-0.211 21. 797-2. 832 1.00 0.00 P ATOM 2147 O1P ADE 8 0.258 23.043-3. 479 1.00 0.00 O ATOM 2148 02P ADE 8-0.082 20.505-3. 543 1.00 0.00 O ATOM 2149 05'ADE 8 0.527 21.660-1. 405 1.00 0.00 O ATOM 2150 C5'ADE 8 0.525 22. 744-0.470 1. 00 0.00 C ATOM 2151 C4'ADE 8 1.115 22.327 0.876 1.00 0.00 C ATOM 2152 04'ADE 8 0.462 21.157 1.396 1.00 0.00 O ATOM 2153 C1'ADE 8 1.452 20.196 1.810 1.00 0.00 C ATOM 2154 N9 ADE 8 1.561 19.085 0. 843 1.00 0.00 N ATOM 2155 C4 ADE 8 2.239 17.896 1.020 1. 00 0.00 C ATOM 2156 N3 ADE 8 2.915 17. 512 2.124 1.00 0.00 N

ATOM 2157 C2 ADE 8 3.456 16.306 1.965 1.00 0.00 C ATOM 2158 N1 ADE 8 3. 382 15. 525 0.886 1.00 0. 00' N ATOM 2159 C6 ADE 8 2.703 15.930-0. 202 1.00 0.00 C ATOM 2160 N6 ADE 8 2.643 15.137-1. 271 1.00 0.00 N ATOM 2161 C5 ADE 8 2.090 17.186-0. 149 1.00 0.00 C ATOM 2162 N7 ADE 8 1.324 17.904-1. 072 1.00 0.00 N ATOM 2163 C8 ADE 8 1.065 18.982-0. 414 1.00 0.00 C ATOM 2164 C2'ADE 8 2.755 20.971 1.891 1.00 0.00 C ATOM 2165 02'ADE 8 2.887 21.651 3.145 1.00 0.00 0 ATOM 2166 C3'ADE 8 2.581 21.939 0.740 1.00 0.00 C ATOM 2167 03'ADE 8 3.393 23.093 0.986 1.00 0.00 0 ATOM 2168 1H5'ADE 8-0.500 23.082-0. 319 1.00 0.00 H ATOM 2169 2H5'ADE 8 1.113 23.567-0. 877 1.00 0.00 H ATOM 2170 H4'ADE 8 1.015 23.143 1.589 1.00 0.00 H ATOM 2171 Hl'ADE 8 1.195 19.804 2.793 1.00 0.00 H ATOM 2172 H2 ADE 8 4.026 15.913 2.809 1.00 0.00 H ATOM 2173 1H6 ADE 8 3.104 14.239-1. 260 1.00 0.00 H ATOM 2174 2H6 ADE 8 2.138 15.436-2. 093 1.00 0.00 H ATOM 2175 H8 ADE 8 0.475 19.785-0. 854 1.00 0.00 H ATOM 2176 H2'ADE 8 3.602 20.307 1.708 1.00 0.00 H ATOM 2177 H02'ADE 8 2.112 22.207 3.252 1.00 0.00 H ATOM 2178 H3'ADE 8 2.795 21.470-0. 221 1.00 0.00 H ATOM 2179 P ADE 9 3.873 24.038-0. 229 1.00 0.00 P ATOM 2180 01P ADE 9 4.969 24.901 0.264 1.00 0.00 0 ATOM 2181 02P ADE 9 2. 674 24.649-0. 845 1.00 0.00 0 ATOM 2182 05'ADE 9 4.495 22. 982-1. 274 1.00 0.00 O ATOM 2183 C5'ADE 9 5.240 23.437-2. 409 1.00 0.00 C ATOM 2184 C4'ADE 9 5.783 22.274-3. 240 1.00 0.00 C ATOM 2185 04'ADE 9 6.541 21.365-2. 434 1.00 0.00 0 ATOM 2186 C1'ADE 9 5. 807 20.141-2. 260 1.00 0.00 C ATOM 2187 N9 ADE 9 5.823 19.716-0. 850 1.00 0.00 N ATOM 2188 C4 ADE 9 6.220 18.494-0. 363 1.00 0.00 C ATOM 2189 N3 ADE 9 6.657 17.450-1. 090 1.00 0.00 N ATOM 2190 C2 ADE 9 6.964 16.418-0. 315 1.00 0.00 C ATOM 2191 N1 ADE 9 6.874 16.350 1. 014 1.00 0.00 N ATOM 2192 C6 ADE 9 6.434 17.406 1. 720 1.00 0.00 C ATOM 2193 N6 ADE 9 6.355 17.319 3.047 1.00 0.00 N ATOM 2194 C5 ADE 9 6.082 18.555 1.005 1.00 0.00 C ATOM 2195 N7 ADE 9 5.599 19.806 1.398 1.00 0.00 N ATOM 2196 C8 ADE 9 5.481 20.406 0.261 1.00 0.00 C ATOM 2197 C2'ADE 9 4.389 20.437-2. 731 1.00 0.00 C ATOM 2198 02'ADE 9 3.734 19.260-3. 220 1.00 0.00 O ATOM 2199 C3'ADE 9 4.654 21.434-3. 839 1.00 0.00 C ATOM 2200 03'ADE 9 5.145 20.704-4. 981 1.00 0. 00. 0 ATOM 2201 1ADE 9 6.076 24.044-2. 062 1.00 0.00 H ATOM 2202 2H5'ADE 9 4.592 24.049-3. 036 1.00 0.00 H ATOM 2203 H4'ADE 9 6.417 22.664-4. 032 1. 00 0.00 H ATOM 2204 Hl'ADE 9 6. 244 19.360-2. 883 1.00 0.00 H ATOM 2205 H2 ADE 9 7.336 15.531-0. 820 1.00 0.00 H ATOM 2206 1H6 ADE 9 6.027 18.108 3.586 1.00 0.00 H ATOM 2207 2H6 ADE 9 6.625 16.465 3.515 1.00 0.00 H ATOM 2208 H8 ADE 9 5.117 21. 430 0.197 1. 00 0.00 H ATOM 2209 H2'ADE 9 3.814 20. 909-1. 932 1.00 0.00 H ATOM 2210 H02'ADE 9 4.288 18.891-3. 911 1.00 0.00 H ATOM 2211 H3'ADE 9 3.774 22.033-4. 071 1.00 0.00 H ATOM 2212 P URI 10 6.118 21.379-6. 079 1.00 0.00 P ATOM 2213 01P URI 10 6.251 20.445-7. 219 1.00 0.00 0 ATOM 2214 02P URI 10 5.665 22.769-6. 312 1.00 0.00 O ATOM 2215 05'URI 10 7. 528 21.431-5. 300 1.00 0.00 0 ATOM 2216 C5'URI 10 8.760 21.610-6. 006 1.00 0.00 C

ATOM 2217 C4'URI 10 9.798 20.573-5. 582 1.00 0.00 C ATOM 2218 04'URI 10 9.379 19.243-5. 919 1.00 0.00 0 ATOM 2219 C1'URI 10 10.194 18.730-6. 989 1.00 0.00 C ATOM 2220 N1 URI 10 9.366 18.077-8. 028 1.00 0.00 N ATOM 2221 C6 URI 10 8.001 18.179-8. 004 1.00 0.00 C ATOM 2222 C2 URI 10 10.020 17.371-9. 025 1.00 0.00 C ATOM 2223 02 URI 10 11.245 17.267-9. 064 1.00 0.00 0 ATOM 2224 N3 URI 10 9.213 16.784-9. 982 1.00 0.00 N ATOM 2225 C4 URI 10 7.831 16.840-10. 030 1.00 0.00 C ATOM 2226 04 URI 10 7.213 16.278-10. 932 1.00 0.00 0 ATOM 2227 C5 URI 10 7.234 17.596-8. 953 1.00 0.00 C ATOM 2228 C2'URI 10 10.934 19.935-7. 555 1.00 0.00 C ATOM 2229 02'URI 10 12.190 19.563-8. 137 1.00 0.00 0 ATOM 2230 C3'URI 10 11.119 20.779-6. 310 1.00 0.00 C ATOM 2231 03'URI 10 12.165 20.201-5. 519 1.00 0.00 0 ATOM 2232 1H5'URI 10 9.147 22.607-5. 797 1.00 0.00 H ATOM 2233 2H5'URI 10 8.578 21.517-7. 077 1.00 0.00 H ATOM 2234 H4'URI 10 9.958 20.638-4. 508 1.00 0.00 H ATOM 2235 H1'URI 10 10.914 18.014-6. 590 1.00 0.00 H ATOM 2236 H6 URI 10 7.522 18.738-7. 202 1.00 0.00 H ATOM 2237 H3 URI 10 9.676 16.265-10. 714 1.00 0.00 H ATOM 2238 H5 URI 10 6.151 17.702-8. 905 1.00 0.00 H ATOM 2239 H2'URI 10 10.302 20.461-8. 276 1.00 0.00 H ATOM 2240 H02'URI 10 12.014 18. 864-8. 773 1.00 0.00 H ATOM 2241 H3'URI 10 11.303 21.829-6. 544 1.00 0.00 H ATOM 2242 P GUA 11 12.784 20.990-4. 257 1.00 0.00 P ATOM 2243 01P GUA 11 13.799 20.121-3. 622 1.00 0.00 0 ATOM 2244 02P GUA 11 13.154 22.354-4. 698 1.00 0.00 0 ATOM 2245 05'GUA 11 11.525 21.104-3. 255 1.00 0.00 0 ATOM 2246 C5'GUA 11 10.994 22.383-2. 890 1.00 0.00 C ATOM 2247 C4'GUA 11 10.205 22.315-1. 585 1.00 0.00 C ATOM 2248 04'GUA 11 9.085 21.422-1. 685 1.00 0.00 0 ATOM 2249 C1'GUA 11 9.056 20.560-0. 532 1.00 0.00 C ATOM 2250 N9 GUA 11 9.495 19.197-0. 880 1.00 0.00 N ATOM 2251 C4 GUA 11 9.649 18.137-0. 018 1.00 0.00 C ATOM 2252 N3 GUA 11 9.441 18.166 1.316 1.00 0.00 N ATOM 2253 C2 GUA 11 9.672 16.981 1.888 1.00 0.00 C ATOM 2254 N2 GUA 11 9.515 16.836 3.203 1.00 0.00 N ATOM 2255 N1 GUA 11 10.076 15.860 1.191 1.00 0.00 N ATOM 2256 C6 GUA 11 10.296 15.807-0. 179 1.00 0.00 C ATOM 2257 06 GUA 11 10.657 14.757-0. 706 1.00 0.00 O ATOM 2258 C5 GUA 11 10.054 17.062-0. 794 1.00 0.00 C ATOM 2259 N7 GUA 11 10.157 17.436-2. 137 1.00 0.00 N ATOM 2260 C8 GUA 11 9.817 18.680-2. 088 1.00 0.00 C ATOM 2261 C2'GUA 11 9.998 21.204 0.474 1. 00 0.00 C ATOM 2262 02'GUA 11 9.349 22.245 1.215 1.00 0.00 O ATOM 2263 C3'GUA 11 11.056 21. 754-0. 457 1.00 0.00 C ATOM 2264 03'GUA 11 11.733 22.833 0.192 1.00 0.00 O ATOM 2265 1H5'GUA 11 10.336 22.737-3. 684 1.00 0.00 H ATOM 2266 2H5'GUA 11 11.817 23.088-2. 770 1.00 0.00 H ATOM 2267 H4'GUA 11 9.851 23.309-1. 317 1.00 0.00 H ATOM 2268 H1'GUA 11 8.046 20.525-0. 123 1.00 0.00 H ATOM 2269 1H2 GUA 11 9.689 15.941 3.637 1.00 0. 00 H ATOM 2270 2H2 GUA 11 9.221 17.622 3.766 1. 00 0.00 H ATOM 2271 Hl GUA 11 10.230 15.001 1.698 1.00 0.00 H ATOM 2272 H8 GUA 11 9.793 19.295-2. 984 1.00 0.00 H ATOM 2273 H2'GUA 11 10.424 20.448 1.140 1.00 0.00 H ATOM 2274 H02'GUA 11 8.946 22.839 0.578 1. 00 0.00 H ATOM 2275 H3'GUA 11 11. 738 20.975-0. 804 1.00 0.00 H ATOM 2276 P CYT 12 13.283 22.688 0.601 1.00 0.00 P

ATOM 2277 O1P CYT 12 13.730 23. 972 1.187 1.00 0. 00 O ATOM 2278 02P CYT 12 14.014 22.107-0. 547 1.00 0.00 0 ATOM 2279 05'CYT 12 13.231 21.588 1.775 1.00 0.00 0 ATOM 2280 C5'CYT 12 12.734 21.935 3.070 1.00 0.00 C ATOM 2281 C4'CYT 12 12.678 20.725 3.997 1.00 0.00 C ATOM 2282 04'CYT 12 11.815 19.702 3.491 1.00 0.00 0 ATOM 2283 Cl'CYT 12 12.386 18.410 3.784 1.00 0.00 C ATOM 2284 Nl CYT 12 12.720 17.672 2.544 1.00 0.00 N ATOM 2285 C6 CYT 12 12.725 18.299 1.329 1.00 0.00 C ATOM 2286 C2 CYT 12 13. 003 16.316 2.659 1.00 0.00 C ATOM 2287 02 CYT 12 13. 016 15.776 3.764 1.00 0.00 0 ATOM 2288 N3 CYT 12 13.280 15.617 1.525 1.00 0.00 N ATOM 2289 C4 CYT 12 13.284 16.218 0.329 1.00 0.00 C ATOM 2290 N4 CYT 12 13.535 15. 497-0. 763 1.00 0.00 N ATOM 2291 C5 CYT-12 13.001 17.613 0.205 1.00 0.00 C ATOM 2292 C2'CYT 12 13.636 18.681 4.618 1. 00 0. 00 C ATOM 2293 02'CYT 12 13.337 18.690 6.019 1.00 0.00 0 ATOM 2294 C3'CYT 12 14.033 20.053 4.119 1.00 0.00 C ATOM 2295 03'CYT 12 14.786 20.722 5.134 1.00 0.00 0 ATOM 2296 1H5'CYT 12 11. 731 22.350 2.968 1.00 0.00 H ATOM 2297 2H5'CYT 12 13. 388 22. 689 3.510 1.00 0.00 H ATOM 2298 H4'CYT 12 12.332 21.033 4.983 1.00 0.00 H ATOM 2299 Hl'CYT 12 11.678 17.828 4.373 1.00 0.00 H ATOM 2300 H6 CYT 12 12.502 19. 364 1.269 1.00 0.00 H ATOM 2301 1H4 CYT 12 13.526 15.937-1. 672 1.00 0.00 H ATOM 2302 2H4 CYT 12 13.727 14.509-0. 682 1.00 0.00 H ATOM 2303 H5 CYT 12 13. 013 18.105-0. 767 1.00 0.00 H ATOM 2304 H2'CYT 12 14.411 17.949 4.386 1.00 0.00 H ATOM 2305 H02'CYT 12 13.048 17.805 6.252 1.00 0.00 H ATOM 2306 H3'CYT 12 14.560 20.002 3.165 1.00 0.00 H ATOM 2307 P URI 13 16.392 20.790 5.043 1.00 0.00 P ATOM 2308 01P URI 13 16.874 21.746 6.065 1.00 0.00 0 ATOM 2309 02P URI 13 16.769 20.976 3.624 1.00 0. 00 0 ATOM 2310 05'URI 13 16.827 19.307 5.490 1.00 0.00 0 ATOM 2311 C5'URI 13 16.695 18.891 6.852 1.00 0.00 C ATOM 2312 C4'URI 13 16.845 17.380 6.995 1.00 0.00 C ATOM 2313 04'URI 13 15.863 16. 675 6.227 1.00 0.00 0 ATOM 2314 C1'URI 13 16. 464 15.497 5.651 1. 00 0.00 C ATOM 2315 N1 URI 13 16. 466 15.558 4.171 1.00 0.00 N ATOM 2316 C6 URI 13 16. 369 16.754 3.506 1.00 0.00 C ATOM 2317 C2 URI 13 16. 554 14.358 3.485 1.00 0.00 C ATOM 2318 02 URI 13 16.653 13.277 4.063 1. 00 0. 00 O ATOM 2319 N3 URI 13 16. 534 14.443 2. 107 1.00 0.00 N ATOM 2320 C4 URI 13 16.433 15.603 1.361 1.00 0.00 C ATOM 2321 04 URI 13 16.409 15.557 0.133 1.00 0. 00 0 ATOM 2322 C5 URI 13 16.350 16.808 2.153 1.00 0.00 C ATOM 2323 C2'URI 13 17. 886 15.435 6.202 1.00 0.00 C ATOM 2324 02'URI 13 17.944 14. 675 7.415 1.00 0. 00 0 ATOM 2325 C3'URI 13 18. 175 16.901 6.447 1. 00 0.00 C ATOM 2326 03'URI 13 19.166 17.013 7.474 1.00 0.00 0 ATOM 2327 1H5'URI 13 15.713 19.187 7.222 1.00 0.00 H ATOM 2328 2H5'URI 13 17.463 19.383 7. 449 1.00 0.00 H ATOM 2329 H4'URI 13 16.755 17. 098 8.043 1.00 0. 00 H ATOM 2330 H1'URI 13 15.912 14.615 5. 977 1.00 0.00 H ATOM 2331 H6 URI 13 16.309 17.681 4.077 1.00 0.00 H ATOM 2332 H3 URI 13 16.602 13.576 1.596 1.00 0.00 H ATOM 2333 H5 URI 13 16.271 17.774 1.656 1.00 0.00 H ATOM 2334 H2'URI 13 18.567 15.031 5.450 1.00 0.00 H ATOM 2335 H02'URI 13 18.767 14.901 7.854 1. 00 0. 00 H ATOM 2336 H3'URI 13 18.455 17.422 5.530 1.00 0. 00 H

ATOM 2337 P CYT 14 20.726 17.130 7.093 1.00 0.00 P ATOM 2338 01P CYT 14 21.486 17.401 8.334 1.00 0.00 0 ATOM 2339 02P CYT 14 20.854 18.044 5.936 1.00 0.00 0 ATOM 2340 05'CYT 14 21.079 15.639 6.598 1.00 0.00 0 ATOM 2341 C5'CYT 14 21.309 14.590 7.544 1.00 0.00 C ATOM 2342 C4'CYT 14 21.522 13.246 6.852 1.00 0.00 C ATOM 2343 04'CYT 14 20.396 12.887 6.044 1.00 0.00 0 ATOM 2344 Cl'CYT 14 20.853 12.291 4.814 1.00 0.00 C ATOM 2345 N1 CYT 14 20.469 13.107 3.642 1.00 0.00 N ATOM 2346 C6 CYT 14 20.323 14.460 3.742 1.00 0.00 C ATOM 2347 C2 CYT 14 20.274 12.445 2.437 1.00 0.00 C ATOM 2348 02 CYT 14 20.417 11.225 2.369 1.00 0.00 0 ATOM 2349 N3 CYT 14 19.929 13.180 1.346 1.00 0.00 N ATOM 2350 C4 CYT 14 19.782 14.508 1.430 1.00 0.00 C ATOM 2351 N4 CYT 14 19.445 15.197 0.342 1.00 0.00 N ATOM 2352 C5 CYT 14 19.983 15.194 2.669 1.00 0.00 C ATOM 2353 C2'CYT 14 22.370 12.181 4.926 1.00 0.00 C ATOM 2354 02'CYT 14 22.766 10.906 5.447 1.00 0.00 0 ATOM 2355 C3'CYT 14 22.694 13.306 5.889 1.00 0.00 C ATOM 2356 03'CYT 14 23.888 12.970 6.601 1.00 0.00 0 ATOM 2357 1H5'CYT 14 20. 449 14.514 8.210 1.00 0.00 H ATOM 2358 2H5'CYT 14 22.195 14.830 8.133 1.00 0.00 H ATOM 2359 H4'CYT 14 21.697 12.471 7.596 1.00 0.00 H ATOM 2360 H1'CYT 14 20.425 11.293 4.716 1.00 0.00 H ATOM 2361 H6 CYT 14 20.482 14.951 4.702 1.00 0.00 H ATOM 2362 1H4 CYT 14 19.331 16.199 0.393 1.00 0.00 H ATOM 2363 2H4 CYT 14 19.309 14.717-0. 537 1.00 0.00 H ATOM 2364 H5 CYT 14 19.872 16.274 2.739 1.00 0.00 H ATOM 2365 H2'CYT 14 22.831 12.370 3.953 1.00 0.00 H ATOM 2366 H02'CYT 14 22.576 10.251 4.771 1.00 0.00 H ATOM 2367 H3'CYT 14 22.763 14.270 5.382 1.00 0.00 H ATOM 2368 P URI 15 25.325 13.458 6.064 1.00 0.00 P ATOM 2369 01P URI 15 25.290 14.931 5.919 1.00 0.00 0 ATOM 2370 02P URI 15 26. 371 12.824 6.896 1.00 0.00 0 ATOM 2371 05'URI 15 25.389 12.811 4.590 1.00 0.00 0 ATOM 2372 C5'URI 15 25.636 11.412 4.413 1.00 0.00 C ATOM 2373 C4'URI 15 25.449 10.991 2.957 1.00 0.00 C ATOM 2374 04'URI 15 24. 104 11.217 2.508 1.00 0. 00 0 ATOM 2375 C1'URI 15 24. 129 11.822 1.200 1.00 0.00 C ATOM 2376 N1 URI 15 23.701 13.239 1.256 1.00 0.00 N ATOM 2377 C6 URI 15 24.026 14.031 2.324 1.00 0.00 C ATOM 2378 C2 URI 15 22.974 13.733 0. 187 1.00 0.00 C ATOM 2379 02 URI 15 22.671 13.038-0. 778 1.00 0.00 0 ATOM 2380 N3 URI 15 22.604 15.062 0.267 1.00 0.00 N ATOM 2381 C4 URI 15 22.892 15.929 1.306 1.00 0.00 C ATOM 2382 04 URI 15 22.510 17.096 1.272 1.00 0.00 0 ATOM 2383 C5 URI 15 23.653 15.330 2.378 1.00 0.00 C ATOM 2384 C2'URI 15 25.570 11.702 0.720 1.00 0. 00 C ATOM 2385 02'URI 15 25.813 10.441 0.083 1.00 0.00 0 ATOM 2386 C3'URI 15 26.321 11.821 2.029 1.00 0.00 C ATOM 2387 03'URI 15 27.592 11.179 1.895 1.00 0.00 0 ATOM 2388 1H5'URI 15 24.946 10.845 5.039 1.00 0.00 H ATOM 2389 2H5'URI 15 26.658 11.191 4.718 1.00 0.00 H ATOM 2390 H4'URI 15 25.695 9.936 2.845 1.00 0.00 H ATOM 2391 H1'URI 15 23.473 11.267 0.529 1.00 0.00 H ATOM 2392 H6 URI 15 24. 592 13.605 3.152 1.00 0.00 H ATOM 2393 H3 URI 15 22.072 15.436-0. 505 1.00 0.00 H ATOM 2394 H5 URI 15 23.936 15.932 3.240 1.00 0.00 H ATOM 2395 H2'URI 15 25.821 12.535 0.057 1.00 0.00 H ATOM 2396 H02'URI 15 25.259 10.406-0. 701 1.00 0.00 H

ATOM 2397 H3'URI 15 26.404 12.859 2.359 1.00 0.00 H ATOM 2398 P URI 16 28.874 12.007 1.379 1.00 0.00 P ATOM 2399 01P URI 16 30.069 11.146 1.524 1.00 0.00 0 ATOM 2400 02P URI 16 28.847 13.345 2.012 1.00 0.00 O ATOM 2401 05'URI 16 28.567 12.186-0. 192 1.00 0.00 O ATOM 2402 C5'URI 16 29.484 12.888-1. 038 1.00 0.00 C ATOM 2403 C4'URI 16 30.009 11.994-2. 154 1.00 0.00 C ATOM 2404 04'URI 16 30.522 10.758-1. 632 1.00 0.00 0 ATOM 2405 C1'URI 16 29.861 9.656-2. 263 1.00 0.00 C ATOM 2406 N1 URI 16 29.684 8.529-1. 320 1. 00 0.00 N ATOM 2407 C6 URI 16 28.941 8.675-0. 178 1.00 0.00 C ATOM 2408 C2 URI 16 30.294 7.327-1. 636 1.00 0.00 C ATOM 2409 02 URI 16 30.964 7.177-2. 656 1.00 0.00 O ATOM 2410 N3 URI 16 30.106 6.296-0. 733 1.00 0.00 N ATOM 2411 C4 URI 16 29.373 6.360 0. 440 1.00 0.00 C ATOM 2412 04 URI 16 29.274 5.376 1.170 1.00 0.00 0 ATOM 2413 C5 URI 16 28.773 7.650 0.690 1.00 0.00 C ATOM 2414 C2'URI 16 28. 522 10.203-2. 726 1.00 0.00 C ATOM 2415 02'URI 16 27.999 9.459-3. 833 1.00 0.00 0 ATOM 2416 C3'URI 16 28.891 11.620-3. 127 1.00 0.00 C ATOM 2417 03'URI 16 29.440 11.599-4. 447 1.00 0.00 0 ATOM 2418 1H5'URI 16 30.318 13.246-0. 444 1.00 0.00 H ATOM 2419 2H5'URI 16 28.980 13.743-1. 482 1.00 0.00 H ATOM 2420 H4'URI 16 30.802 12.512-2. 692 1.00 0.00 H ATOM 2421 H1'URI 16 30.440 9.328-3. 126 1.00 0.00 H ATOM 2422 H6 URI 16 28.475 9.636 0.037 1.00 0.00 H ATOM 2423 H3 URI 16 30.544 5.413-0. 951 1.00 0.00 H ATOM 2424 H5 URI 16 28.175 7.799 1.589 1.00 0.00 H ATOM 2425 H2'URI 16 27.812 10.224-1. 895 1.00 0.00 H ATOM 2426 H02'URI 16 28. 641 9. 520-4.545 1.00 0.00 H ATOM 2427 H3'URI 16 28.042 12.299-3. 050 1.00 0.00 H ATOM 2428 P CYT 17 29.697 12.980-5. 235 1.00 0.00 P ATOM 2429 O1P CYT 17 29.894 12.667-6. 669 1.00 0.00 O ATOM 2430 02P CYT 17 30.724 13.752-4. 501 1.00 0.00 0 ATOM 2431 05'CYT 17 28.284 13.735-5. 071 1.00 0.00 0 ATOM 2432 C5'CYT 17 27.107 13.200-5. 682 1.00 0.00 C ATOM 2433 C4'CYT 17 25.864 14.012-5. 340 1.00 0.00 C ATOM 2434 04'CYT 17 25.604 14.006-3. 928 1.00 0. 00 0 ATOM 2435 C1'CYT 17 25.409 15.349-3. 487 1.00 0.00 C ATOM 2436 N1 CYT 17 25.799 15.518-2. 073 1.00 0.00 N ATOM 2437 C6 CYT 17 26.702 14.681-1. 501 1.00 0.00 C ATOM 2438 C2 CYT 17 25.208 16.551-1. 355 1.00 0.00 C ATOM 2439 02 CYT 17 24.391 17.295-1. 895 1.00 0.00 O ATOM 2440 N3 CYT 17 25. 559 16.708-0. 049 1.00 0.00 N ATOM 2441 C4 CYT 17 26.448 15.890 0.527 1.00 0.00 C ATOM 2442 N4 CYT 17 26.769 16.067 1.808 1.00 0.00 N ATOM 2443 C5 CYT 17 27.055 14.829-0. 214 1.00 0.00 C ATOM 2444 C2'CYT 17 26.275 16.180-4. 411 1.00 0.00 C ATOM 2445 02'CYT 17 25. 852 17.548-4. 452 1.00 0.00 0 ATOM 2446 C3'CYT 17 26.041 15.476-5. 740 1.00 0.00 C ATOM 2447 03'CYT 17 24.802 15.943-6. 290 1.00 0.00 0 ATOM 2448 1H5'CYT 17 26.964 12.179-5. 342 1.00 0.00 H ATOM 2449 2H5'CYT 17 27. 241 13.198-6. 759 1.00 0.00 H ATOM 2450 H4'CYT 17 25. 006 13.596-5. 864 1.00 0.00 H ATOM 2451 H1'CYT 17 24. 368 15.626-3. 614 1.00 0. 00 H ATOM 2452 H6 CYT 17 27.141 13. 880-2. 093 1.00 0.00 H ATOM 2453 1H4 CYT 17 27. 438 15.454 2.251 1.00 0.00 H ATOM 2454 2H4 CYT 17 26. 344 16.816 2.337 1.00 0.00 H ATOM 2455 H5 CYT 17 27. 780 14.163 0.246 1.00 0.00 H ATOM 2456 H2'CYT 17 27.327 16.097-4. 121 1.00 0. 00 H

ATOM 2457 H02'CYT 17 26.302 17.964-5. 191 1.00 0.00 H ATOM 2458 H3'CYT 17 26.875 15.607-6. 428 1.00 0.00 H ATOM 2459 P GUA 18 24.627 16.149-7. 879 1.00 0.00 P ATOM 2460 01P GUA 18 23.304 16.766-8. 123 1.00 0.00 0 ATOM 2461 02P GUA 18 25.850 16.800-8. 400 1.00 0.00 0 ATOM 2462 05'GUA 18 24.588 14.637-8. 435 1.00 0.00 0 ATOM 2463 C5'GUA 18 23.471 13.783-8. 164 1.00 0.00 C ATOM 2464 C4'GUA 18 23.708 12.372-8. 696 1.00 0.00 C ATOM 2465 04'GUA 18 24.881 11.786-8. 116 1.00 0.00 0 ATOM 2466 C1'GUA 18 24.622 10.412-7. 776 1.00 0.00 C ATOM 2467 N9 GUA 18 24.639 10.207-6. 313 1.00 0.00 N ATOM 2468 C4 GUA 18 24.087 11.032-5. 356 1.00 0.00 C ATOM 2469 N3 GUA 18 23.432 12.191-5. 588 1.00 0.00 N ATOM 2470 C2 GUA 18 23.012 12.770-4. 461 1.00 0.00 C ATOM 2471 N2 GUA 18 22.350 13.925-4. 512 1.00 0.00 N ATOM 2472 N1 GUA 18 23.223 12.240-3. 204 1.00 0.00 N ATOM 2473 C6 GUA 18 23.891 11.052-2. 939 1.00 0.00 C ATOM 2474 06 GUA 18 24.021 10.664-1. 782 1.00 0.00 0 ATOM 2475 C5 GUA 18 24.342 10.431-4. 133 1.00 0.00 C ATOM 2476 N7 GUA 18 25.048 9.238-4. 308 1.00 0.00 N ATOM 2477 C8 GUA 18 25.173 9.191-5. 591 1.00 0.00 C ATOM 2478 C2'GUA 18 23.251 10.083-8. 361 1.00 0.00 C ATOM 2479 02'GUA 18 23.358 9.589-9. 702 1.00 0.00 0 ATOM 2480 C3'GUA 18 22.569 11.436-8. 317 1.00 0.00 C ATOM 2481 03'GUA 18 21.572 11.480-9. 346 1.00 0.00 0 ATOM 2482 1H5'GUA 18 22.581 14.198-8. 637 1.00 0.00 H ATOM 2483 2H5'GUA 18 23.312 13.736-7. 087 1.00 0.00 H ATOM 2484 H4'GUA 18 23.816 12.399-9. 779 1.00 0.00 H ATOM 2485 Hl'GUA 18 25.378 9.777-8. 240 1.00 0.00 H ATOM 2486 1H2 GUA 18 22.031 14.364-3. 660 1.00 0.00 H ATOM 2487 2H2 GUA 18 22. 166 14.363-5. 404 1.00 0.00 H ATOM 2488 H1 GUA 18 22.874 12.740-2. 398 1.00 0.00 H ATOM 2489 H8 GUA 18 25.690 8.365-6. 078 1.00 0.00 H ATOM 2490 H2'GUA 18 22.726 9.370-7. 719 1.00 0.00 H ATOM 2491 H02'GUA 18 23.847 10.242-10. 208 1.00 0.00 H ATOM 2492 H3'GUA 18 22.166 11.658-7. 328 1.00 0.00 H ATOM 2493 P GUA 19 20.030 11.787-8. 990 1.00 0. 00 P ATOM 2494 01P GUA 19 19.230 11.635-10. 226 1.00 0.00 0 ATOM 2495 02P GUA 19 19.975 13.055-8. 227 1.00 0.00 0 ATOM 2496 05'GUA 19 19.647 10.582-7. 989 1.00 0.00 0 ATOM 2497 C5'GUA 19 19.677 9.222-8. 435 1.00 0.00 C ATOM 2498 C4'GUA 19 20.043 8.266-7. 300 1.00 0.00 C ATOM 2499 04'GUA 19 21.210 8.715-6. 586 1.00 0.00 0 ATOM 2500 C1'GUA 19 20.946 8.666-5. 170 1.00 0.00 C ATOM 2501 N9 GUA 19 20. 654 10.008-4. 625 1.00 0.00 N ATOM 2502 C4 GUA 19 20.581 10.356-3. 294 1.00 0.00 C ATOM 2503 N3 GUA 19 20.815 9. 537-2. 244 1.00 0.00 N ATOM 2504 C2 GUA 19 20.663 10.161-1. 073 1.00 0.00 C ATOM 2505 N2 GUA 19 20.860 9.498 0.067 1.00 0.00 N ATOM 2506 N1 GUA 19 20.307 11.490-0. 954 1. 00 0.00 N ATOM 2507 C6 GUA 19 20.061 12.350-2. 016 1.00 0.00 C ATOM 2508 06 GUA 19 19.747 13.518-1. 803 1.00 0.00 0 ATOM 2509 C5 GUA 19 20.221 11.695-3. 264 1. 00 0. 00 C ATOM 2510 N7 GUA 19 20.070 12.194-4. 561 1.00 0.00 N ATOM 2511 C8 GUA 19 20.340 11.155-5. 275 1.00 0.00 C ATOM 2512 C2'GUA 19 19.733 7.765-5. 031 1. 00 0. 00 C ATOM 2513 02'GUA 19 20.092 6.379-5. 092 1.00 0.00 0 ATOM 2514 C3'GUA 19 18.945 8.199-6. 247 1. 00 0.00 C ATOM 2515 03'GUA 19 18.021 7.164-6. 596 1.00 0.00 0 ATOM 2516 1H5'GUA 19 20.413 9.125-9. 232 1.00 0.00 H

ATOM 2517 2H5'GUA 19 18.695 8. 952-8. 824 1.00 0.00 H ATOM 2518 H4'GUA 19 20.228 7.271-7. 702 1.00 0. 00 H ATOM 2519 Hl'GUA 19 21.797 8.228-4. 647 1.00 0.00 H ATOM 2520 1H2 GUA 19 21.125 8.524 0.044 1.00 0. 00 H ATOM 2521 2H2 GUA 19 20.745 9.970 0.952 1.00 0.00 H ATOM 2522 Hl GUA 19 20.211 11.889-0. 032 1.00 0.00 H ATOM 2523 H8 GUA 19 20.314 11.197-6. 363 1.00 0.00 H ATOM 2524 H2'GUA 19 19.188 7.997-4. 113 1.00 0.00 H ATOM 2525 H02'GUA 19 20.623 6.257-5. 882 1.00 0.00 H ATOM 2526 H3'GUA 19 18.460 9.165-6. 096 1.00 0.00 H ATOM 2527 P ADE 20 16.555 7.126-5. 930 1.00 0.00 P ATOM 2528 01P ADE 20 15.829 5.955-6. 471 1.00 0.00 O ATOM 2529 02P ADE 20 15.960 8.477-6. 039 1.00 0.00 0 ATOM 2530 05'ADE 20 16.882 6.845-4. 379 1.00 0.00 0 ATOM 2531 C5'ADE 20 17.393 5.576-3. 961 1.00 0.00 C ATOM 2532 C4'ADE 20 17.651 5.544-2. 457 1.00 0.00 C ATOM 2533 04'ADE 20 18.626 6.524-2. 066 1.00 0.00 0 ATOM 2534 C1'ADE 20 18.149 7.239-0. 911 1.00 0.00 C ATOM 2535 N9 ADE 20 17.723 8.608-1. 268 1.00 0. 00 N ATOM 2536 C4 ADE 20 17.556 9.669-0. 406 1.00 0. 00 C ATOM 2537 N3 ADE 20 17.731 9.649 0.930 1.00 0.00 N ATOM 2538 C2 ADE 20 17.488 10.841 1.466 1.00 0.00 C ATOM 2539 N1 ADE 20 17.118 11.952 0.827 1.00 0.00 N ATOM 2540 C6 ADE 20 16.951 11.946-0. 506 1.00 0.00 C ATOM 2541 N6 ADE 20 16.597 13.070-1. 127 1.00 0.00 N ATOM 2542 C5 ADE 20 17.177 10.742-1. 178 1.00 0.00 C ATOM 2543 N7 ADE 20 17.097 10.382-2. 526 1.00 0.00 N ATOM 2544 C8 ADE 20 17.427 9.136-2. 481 1.00 0.00 C ATOM 2545 C2'ADE 20 16.980 6.423-0. 383 1.00 0.00 C ATOM 2546 02'ADE 20 17.422 5.360 0.470 1.00 0.00 0 ATOM 2547 C3'ADE 20 16.396 5.901-1. 677 1.00 0.00 C ATOM 2548 03'ADE 20 15.663 4.704-1. 405 1.00 0.00 0 ATOM 2549 1H5'ADE 20 18.327 5.377-4. 486 1.00 0.00 H ATOM 2550 2H5'ADE 20 16.670 4.801-4. 214 1.00 0.00 H ATOM 2551 H4'ADE 20 17.997 4.554-2. 165 1.00 0.00 H ATOM 2552 H1'ADE 20 18.936 7.284-0. 158 1.00 0.00 H ATOM 2553 H2 ADE 20 17.603 10.918 2.547 1.00 0.00 H ATOM 2554 1H6 ADE 20 16.479 13. 077-2. 130 1.00 0.00 H ATOM 2555 2H6 ADE 20 16.450 13.917-0. 596 1.00 0.00 H ATOM 2556 H8 ADE 20 17.453 8.527-3. 383 1.00 0. DO H ATOM 2557 H2'ADE 20 16. 264 7.071 0. 129 1.00 0.00 H ATOM 2558 H02'ADE 20 18.089 4.866-0. 012 1.00 0.00 H ATOM 2559 H3'ADE 20 15.796 6.656-2. 188 1.00 0.00 H ATOM 2560 P GUA 21 14.110 4.785-0. 990 1. 00 0. 00 P ATOM 2561 01P GUA 21 13.421 5.687-1. 941 1.00 0.00 0 ATOM 2562 02P GUA 21 13. 611 3.406-0. 788 1.00 0.00 0 ATOM 2563 05'GUA 21 14.170 5.515 0.443 1.00 0.00 O ATOM 2564 C5'GUA 21 14.560 4.791 1.614 1.00 0.00 C ATOM 2565 C4'GUA 21 14.376 5.627 2.876 1.00 0.00 C ATOM 2566 04'GUA 21 15.233 6.777 2.884 1.00 0.00 0 ATOM 2567 C1'GUA 21 14.500 7.917 3.373 1.00 0.00 C ATOM 2568 N9 GUA 21 14.294 8.915 2.303 1.00 0.00 N ATOM 2569 C4 GUA 21 14.121 10.272 2.466 1.00 0.00 C ATOM 2570 N3 GUA 21 14.061 10.928 3.646 1.00 0.00 N ATOM 2571 C2 GUA 21 13.884 12.243 3.486 1.00 0.00 C ATOM 2572 N2 GUA 21 13.782 13.037 4.551 1.00 0.00 N ATOM 2573 N1 GUA 21 13.781 12. 856 2.253 1. 00 0. 00 N ATOM 2574 C6 GUA 21 13.841 12.205 1.028 1.00 0. 00 C ATOM 2575 06 GUA 21 13. 753 12. 847-0. 015 1.00 0.00 0 ATOM 2576 C5 GUA 21 14.023 10.807 1.190 1.00 0.00 C

ATOM 2577 N7 GUA 21 14.129 9.801 0.225 1.00 0. 00 N ATOM 2578 C8 GUA 21 14.280 8.749 0.957 1.00 0.00 C ATOM 2579 C2'GUA 21 13.172 7.369 3.885 1.00 0.00 C ATOM 2580 02'GUA 21 13.267 6.958 5.254 1.00 0.00 0 ATOM 2581 C3'GUA 21 12.968 6.189 2 : 959 1.00 0.00 C ATOM 2582 03'GUA 21 12.128 5.226 3.603 1.00 0.00 0 ATOM 2583 1H5'GUA 21 15.609 4.506 1.525 1.00 0.00 H ATOM 2584 2H5'GUA 21 13.951 3.891 1.693 1.00 0.00 H ATOM 2585 H4'GUA 21 14.582 5.017 3.754 1.00 0.00 H ATOM 2586 Hl'GUA 21 15.048 8.375 4.197 1.00 0.00 H ATOM 2587 1H2 GUA 21 13.839 12.645 5.480 1.00 0.00 H ATOM 2588 2H2 GUA 21 13.642 14.031 4.430 1.00 0.00 H ATOM 2589 H1 GUA 21 13.651 13.857 2.216 1.00 0.00 H ATOM 2590 H8 GUA 21 14.376 7.761 0.511 1.00 0.00 H ATOM 2591 H2'GUA 21 12.379 8.107 3.747 1.00 0.00 H ATOM 2592 H02'GUA 21 12.403 6.632 5.514 1.00 0.00 H ATOM 2593 H3'GUA 21 12.589 6.496 1.983 1.00 0.00 H ATOM 2594 P ADE 22 10.561 5.132 3.239 1.00 0.00 P ATOM 2595 01P ADE 22 10.071 3.796 3.644 1.00 0.00 0 ATOM 2596 02P ADE 22 10.378 5.594 1.845 1.00 0.00 0 ATOM 2597 05'ADE 22 9.910 6.228 4.222 1. 00. 0.00 O ATOM 2598 C5'ADE 22 9.946 6.040 5.639 1.00 0.00 C ATOM 2599 C4'ADE 22 9.968 7.371 6.385 1.00 0.00 C ATOM 2600 04'ADE 22 11.035 8.213 5.927 1.00 0.00 0 ATOM 2601 C1'ADE 22 10.556 9.564 5.790 1.00 0.00 C ATOM 2602 N9 ADE 22 10.487 9.973 4.371 1.00 0.00 N ATOM 2603 C4 ADE 22 10.601 11.254 3. 881 1.00 0.00 C ATOM 2604 N3 ADE 22 10.793 12.373 4.606 1.00 0.00 N ATOM 2605 C2 ADE 22 10.860 13.448 3.828 1.00 0.00 C ATOM 2606 N1 ADE 22 10.760 13.487 2.498 1.00 0.00 N ATOM 2607 C6 ADE 22 10.569 12.356 1.796 1.00 0.00 C ATOM 2608 N6 ADE 22 10.474 12.415 0.469 1.00 0.00 N ATOM 2609 C5 ADE 22 10.482 11.161 2.514 1.00 0.00 C ATOM 2610 N7 ADE 22 10.291 9.834 2.120 1.00 0.00 N ATOM 2611 C8 ADE 22 10.307 9.221 3.255 1.00 0.00 C ATOM 2612 C2'ADE 22 9.175 9.578 6.431 1.00 0.00 C ATOM 2613 02'ADE 22 9.259 9.821 7.841 1.00 0.00 0 ATOM 2614 C3'ADE 22 8.702 8.172 6.133 1.00 0.00 C ATOM 2615 03'ADE 22 7.719 7.796 7.104 1.00 0.00 0 ATOM 2616 1H5'ADE 22 10.840 5.474 5.901 1.00 0.00 H ATOM 2617 2H5'ADE 22 9.066 5.476 5.946 1.00 0.00 H ATOM 2618 H4'ADE 22 10.083 7.192 7.452 1.00 0.00 H ATOM 2619 H1'ADE 22 11.216 10.241 6.333 1.00 0.00 H ATOM 2620 H2 ADE 22 11.013 14.402 4.331 1.00 0.00 H ATOM 2621 1H6 ADE 22 10.332 11.570-0. 066 1.00 0.00 H ATOM 2622 2H6 ADE 22 10.544 13.306-0. 004 1.00 0.00 H ATOM 2623 H8 ADE 22 10.184 8.141 3.314 1.00 0.00 H ATOM 2624 H2'ADE 22 8.533 10.313 5.939 1.00 0.00 H ATOM 2625 H02'ADE 22 9.899 9.202 8.200 1.00 0.00 H ATOM 2626 H3'ADE 22 8.345 8.069 5.107 1.00 0.00 H ATOM 2627 P CYT 23 6.184 8.259 6.942 1.00 0.00 P ATOM 2628 01P CYT 23 5.805 8.120 5.517 1.00 0.00 0 ATOM 2629 02P CYT 23 5.383 7.582 7.987 1.00 0.00 0 ATOM 2630 05'CYT 23 6. 249 9.830 7.293 1. 00 0.00 0 ATOM 2631 C5'CYT 23 6.629 10.268 8.601 1.00 0.00 C ATOM 2632 C4'CYT 23 6.935 11.763 8.630 1.00 0.00 C ATOM 2633 04'CYT 23 7.945 12.117 7.682 1.00 0.00 0 ATOM 2634 C1'CYT 23 7.666 13.427 7.150 1.00 0.00 C ATOM 2635 N1 CYT 23 7.526 13.393 5.676 1.00 0.00 N ATOM 2636 C6 CYT 23 6.955 12.324 5.045 1.00 0.00 C

ATOM 2637 C2 CYT 23 8.000 14.486 4.961 1.00 0.00 C ATOM 2638 02 CYT 23 8.512 15.436 5.551 1.00 0.00 0 ATOM 2639 N3 CYT 23 7.884 14.471 3.606 1.00 0.00 N ATOM 2640 C4 CYT 23 7.327 13.431 2.974 1.00 0.00 C ATOM 2641 N4 CYT 23 7.230 13.451 1.645 1.00 0.00 N ATOM 2642 C5 CYT 23 6.836 12.303 3.703 1.00 0.00 C ATOM 2643 C2'CYT 23 6.373 13.899 7.820 1.00 0.00 C ATOM 2644 02'CYT 23 6.649 14.725 8.957 1.00 0.00 0 ATOM 2645 C3'CYT 23 5.728 12.585 8.225 1.00 0.00 C ATOM 2646 03'CYT 23 4.919 12.801 9.387 1.00 0.00 0 ATOM 2647 1H5'CYT 23 7.516 9.718 8.916 1.00 0.00 H ATOM 2648 2H5'CYT 23 5.815 10.058 9.296 1.00 0.00 H ATOM 2649 H4'CYT 23 7.260 12.054 9.628 1.00 0.00 H ATOM 2650 H1'CYT 23 8.478 14.104 7.420 1.00 0.00 H ATOM 2651 H6 CYT 23 6.590 11.481 5.632 1.00 0.00 H ATOM 2652 1H4 CYT 23 6.812 12.671 1.157 1.00 0.00 H ATOM 2653 2H4 CYT 23 7.573 14.246 1.125 1.00 0.00 H ATOM 2654 H5 CYT 23 6.383 11.456 3.190 1.00 0.00 H ATOM 2655 H2'CYT 23 5.743 14.425 7.097 1.00 0.00 H ATOM 2656 H02'CYT 23 7.190 14.209 9.560 1.00 0.00 H ATOM 2657 H3'CYT 23 5.175 12.129 7.403 1.00 0.00 H ATOM 2658 P GUA 24 3.442 13.432 9.259 1.00 0.00 P ATOM 2659 O1P GUA 24 2.825 12.921 8.014 1.00 0.00 0 ATOM 2660 02P GUA 24 2. 74. 7 13.255 10.553 1.00 0.00 0 ATOM 2661 05'GUA 24 3.749 14.999 9.062 1.00 0.00 0 ATOM 2662 C5'GUA 24 4.358 15.761 10.109 1.00 0.00 C ATOM 2663 C4'GUA 24 3.999 17.239 10.002 1.00 0.00 C ATOM 2664 04'GUA 24 4.451 17. 803 8. 757 1.00 0.00 0 ATOM 2665 C1'GUA 24 3.352 18.462 8.109 1.00 0.00 C ATOM 2666 N9 GUA 24 2.785 17.629 7.034 1.00 0.00 N ATOM 2667 C4 GUA 24 1.802 18. 003 6.154 1.00 0.00 C ATOM 2668 N3 GUA 24 1.186 19.205 6.127 1.00 0.00 N ATOM 2669 C2 GUA 24 0.272 19.279 5.160 1.00 0.00 C ATOM 2670 N2 GUA 24-0.429 20.400 4.991 1.00 0.00 N ATOM 2671 N1 GUA 24-0.006 18.243 4.291 1.00 0.00 N ATOM 2672 C6 GUA 24 0.613 17.001 4.299 1.00 0.00 C ATOM 2673 06 GUA 24 0.292 16.145 3.479 1.00 0.00 0 ATOM 2674 C5 GUA 24 1.587 16.914 5.325 1.00 0.00 C ATOM 2675 N7 GUA 24 2.428 15.854 5.676 1.00 0.00 N ATOM 2676 C8 GUA 24 3.081 16.357 6.669 1.00 0.00 C ATOM 2677 C2'GUA 24 2.332 18.705 9.206 1.00 0.00 C ATOM 2678 02'GUA 24 2.652 19. 869 9.979 1.00 0.00 0 ATOM 2679 C3'GUA 24 2.488 17.433 10.012 1.00 0.00 C ATOM 2680 03'GUA 24 2.063 17.678 11.356 1.00 0.00 0 ATOM 2681 1H5'GUA 24 5.441 15.652 10.046 1.00 0.00 H ATOM 2682 2H5'GUA 24 4.017 15.381 11.072 1.00 0.00 H ATOM 2683 H4'GUA 24 4.446 17.787 10.830 1.00 0.00 H ATOM 2684 H1'GUA 24 3.678 19.415 7.694 1.00 0.00 H ATOM 2685 1H2 GUA 24-0.267 21.192 5.597 1.00 0.00 H ATOM 2686 2H2 GUA 24-1.122 20.458 4.260 1.00 0.00 H ATOM 2687 H1 GUA 24-0.711 18.378 3.588 1.00 0.00 H ATOM 2688 H8 GUA 24 3.841 15.780 7.195 1.00 0.00 H ATOM 2689 H2'GUA 24 1.327 18.772 8.784 1.00 0.00 H ATOM 2690 H02'GUA 24 3.554 19.765 10.289 1.00 0. 00 H ATOM 2691 H3'GUA 24 1.964 16.594 9.552 1.00 0.00 H ATOM 2692 P ADE 25 0.528 17.439 11.779 1. 00 0.00 P ATOM 2693 O1P ADE 25 0.408 17.670 13.236 1.00 0.00 O ATOM 2694 02P ADE 25 0.078 16.156 11. 195 1.00 0.00 0 ATOM 2695 05'ADE 25-0. 231 18.634 11.014 1.00 0.00 0 ATOM 2696 C5'ADE 25-0.030 19. 993 11.411 1.00 0.00 C

ATOM 2697 C4'ADE 25-0.839 20.956 10.549 1.00 0.00 C ATOM 2698 04'ADE 25-0.449 20.890 9.169 1.00 0.00 0 ATOM 2699 C1'ADE 25-1.626 20.860 8.339 1.00 0.00 C ATOM 2700 N9 ADE 25-1.821 19.526 7.736 1.00 0. 00 N ATOM 2701 C4 ADE 25-2.654 19.210 6.685 1.00 0.00 C ATOM 2702 N3 ADE 25-3.446 20.065 6.008 1.00 0.00 N ATOM 2703 C2 ADE 25-4. 124 19.439 5.050 1.00 0.00 C ATOM 2704 N1 ADE 25-4.076 18. 141 4.745 1.00 0.00 N ATOM 2705 C6 ADE 25-3. 277 17.309 5.436 1.00 0.00 C ATOM 2706 N6 ADE 25-3.241 16.017 5.116 1.00 0.00 N ATOM 2707 C5 ADE 25-2.514 17.859 6.470 1.00 0.00 C ATOM 2708 N7 ADE 25-1.601 17.303 7.371 1.00 0.00 N ATOM 2709 C8 ADE 25-1.254 18.337 8.060 1.00 0.00 C ATOM 2710 C2'ADE 25-2. 785 21.216 9.260 1.00 0.00 C ATOM 2711 02'ADE 25-2.948 22. 635 9.379 1.00 0.00 0 ATOM 2712 C3'ADE 25-2.315 20.594 10.557 1.00 0.00 C ATOM 2713 03'ADE 25-2.948 21.264 11.651 1.00 0.00 0 ATOM 2714 iH5'ADE 25 1.029 20. 238 11.321 1.00 0.00 H ATOM 2715 2H5'ADE 25-0.334 20.107 12.452 1.00 0.00 H ATOM 2716 H4'ADE 25-0. 708 21.974 10.912 1.00 0.00 H ATOM 2717 Hl'ADE 25-1.539 21.610 7.552 1.00 0. 00 H ATOM 2718 H2 ADE 25-4.793 20.054 4.448 1.00 0.00 H ATOM 2719 1H6 ADE 25-2.642 15.386 5.630 1.00 0.00 H ATOM 2720 2H6 ADE 25-3.813 15.667 4.361 1.00 0.00 H ATOM 2721 H8 ADE 25-0.534 18.257 8.873 1.00 0.00 H ATOM 2722 H2'ADE 25-3.706 20.738 8.917 1.00 0.00 H ATOM 2723 H02'ADE 25-2.092 23.001 9.615 1.00 0.00 H ATOM 2724 H3'ADE 25-2.476 19.515 10.573 1.00 0.00 H ATOM 2725 P CYT 26-4.392 20.781 12.174 1.00 0. 00 P ATOM 2726 O1P CYT 26-4.380 19.303 12.271 1.00 0.00 0 ATOM 2727 02P CYT 26-4.754 21.596 13.355 1.00 0.00 0 ATOM 2728 05'CYT 26-5.357 21.196 10.955 1.00 0. 00 O ATOM 2729 C5'CYT 26-5.653 22.571 10.699 1.00 0.00 C ATOM 2730 C4'CYT 26-6.575 22.734 9.495 1.00 0.00 C ATOM 2731 04'CYT 26-5.962 22.272 8.282 1.00 0. 00 0 ATOM 2732 C1'CYT 26-6.925 21.521 7.516 1.00 0.00 C ATOM 2733 N1 CYT 26-6.586 20. 082 7.493 1.00 0.00 N ATOM 2734 C6 CYT 26-5.999 19.485 8.570 1.00 0.00 C ATOM 2735 C2 CYT 26-6.890 19.364 6.344 1.00 0.00 C ATOM 2736 02 CYT 26-7.419 19.924 5.385 1.00 0.00 0 ATOM 2737 N3 CYT 26-6.586 18.038 6.313 1.00 0.00 N ATOM 2738 C4 CYT 26-6.009 17.441 7.364 1.00 0. 00 C ATOM 2739 N4 CYT 26-5.713 16.143 7.296 1.00 0.00 N ATOM 2740 C5 CYT 26-5.698 18.177 8.549 1.00 0.00 C ATOM 2741 C2'CYT 26-8. 267 21.754 8.201 1.00 0.00 C ATOM 2742 02'CYT 26-8.902 22.947 7.725 1.00 0.00 0 ATOM 2743 C3'CYT 26-7.827 21.887 9.643 1.00 0.00 C ATOM 2744 03'CYT 26-8.805 22.641 10.366 1.00 0.00 0 ATOM 2745 1H5'CYT 26-4. 723 23.108 10.510 1. 00 0.00 H ATOM 2746 2H5'CYT 26-6.138 22.998 11.577 1.00 0.00 H ATOM 2747 H4'CYT 26-6.852 23. 781 9.383 1.00 0.00 H ATOM 2748 H1'CYT 26-6.963 21.905 6.497 1.00 0.00 H ATOM 2749 H6 CYT 26-5. 766 20.076 9.456 1.00 0.00 H ATOM 2750 1H4 CYT 26-5.272 15. 684 8.080 1.00 0.00 H ATOM 2751 2H4 CYT 26-5.926 15.620 6.459 1.00 0.00 H ATOM 2752 H5 CYT 26-5.245 17.695 9.412 1.00 0.00 H ATOM 2753 H2'CYT 26-8.914 20.882 8.074 1.00 0.00 H ATOM 2754 H02'CYT 26-8.273 23.665 7.828 1.00 0.00 H ATOM 2755 H3'CYT 26-7.616 20.916 10.098 1.00 0. 00 H ATOM 2756 P CYT 27-9. 497 22. 032 11.688 1.00 0.00 P

ATOM 2757 01P CYT 27-8.529 21.123 12.343 1.00 0.00 0 ATOM 2758 02P CYT 27-10.097 23.148 12.453 1.00 0.00 0 ATOM 2759 05'CYT 27-10.689 21.140 11.075 1.00 0.00 0 ATOM 2760 C5'CYT 27-11.652 21.727 10.195 1. 00 0.00 C ATOM 2761 C4'CYT 27-11.994 20.799 9.034 1.00 0.00 C ATOM 2762 04'CYT 27-10.820 20.341 8.357 1.00 0.00 O ATOM 2763 C1'CYT 27-11.037 18.992 7.894 1.00 0.00 C ATOM 2764 N1 CYT 27-10.058 18.043 8.473 1.00 0.00 N ATOM 2765 C6 CYT 27-9.326 18.359 9.584 1.00 0. 00 C ATOM 2766 C2 CYT 27-9.938 16.805 7.858 1.00 0.00 C ATOM 2767 02 CYT 27-10.603 16.548 6.859 1.00 0.00 O ATOM 2768 N3 CYT 27-9.074 15.899 8.388 1.00 0.00 N ATOM 2769 C4 CYT 27-8.354 16.190 9.477 1.00 0.00 C ATOM 2770 N4 CYT 27-7.524 15.272 9.971 1.00 0.00 N ATOM 2771 C5 CYT 27-8. 467 17.465 10.117 1.00 0.00 C ATOM 2772 C2'CYT 27-12.460 18. 622 8.314 1.00 0.00 C ATOM 2773 02'CYT 27-13.403 18.899 7.271 1.00 0.00 0 ATOM 2774 C3'CYT 27-12.667 19.527 9.511 1.00 0.00 C ATOM 2775 03'CYT 27-14.069 19.774 9.668 1.00 0.00 0 ATOM 2776 1H5'CYT 27-11.249 22.659 9.796 1.00 0.00 H ATOM 2777 2H5'CYT 27-12.561 21.946 10.756 1.00 0.00 H ATOM 2778 H4'CYT 27-12.640 21.315 8.326 1.00 0.00 H ATOM 2779 H1'CYT 27-10.965 18.969 6.806 1.00 0.00 H ATOM 2780 H6 CYT 27-9.434 19.344 10.040 1.00 0.00 H ATOM 2781 1H4 CYT 27-6.975 15.478 10.794 1.00 0. 00 H ATOM 2782 2H4 CYT 27-7.452 14.367 9.528 1.00 0.00 H ATOM 2783 H5 CYT 27-7.885 17.701 11. 009 1.00 0.00 H ATOM 2784 H2'CYT 27-12. 505 17.573 8.617 1.00 0.00 H ATOM 2785 H02'CYT 27-13.236 18.275 6.561 1.00 0.00 H ATOM 2786 H3'CYT 27-12.203 19.127 10.413 1.00 0.00 H ATOM 2787 P GUA 28-14.986 18.776 10.541 1.00 0. 00 P ATOM 2788 01P GUA 28-16.322 19.392 10.697 1.00 0.00 O ATOM 2789 02P GUA 28-14. 218 18.369 11.740 1.00 0.00 O ATOM 2790 05'GUA 28-15.130 17.492 9.578 1.00 0.00 0 ATOM 2791 C5'GUA 28-15.904 17.570 8.377 1.00 0.00 C ATOM 2792 C4'GUA 28-15.888 16.254 7.602 1.00 0.00 C ATOM 2793 04'GUA 28-14.558 15.831 7.298 1.00 0.00 0 ATOM 2794 C1'GUA 28-14.506 14.391 7.303 1.00 0.00 C ATOM 2795 N9 GUA 28-13.498 13.887 8.258 1.00 0.00 N ATOM 2796 C4 GUA 28-13.153 12.570 8.461 1.00 0.00 C ATOM 2797 N3 GUA 28-13.688 11.506 7.823 1.00 0.00 N ATOM 2798 C2 GUA 28-13.153 10.352 8.227 1. 00 0.00 C ATOM 2799 N2 GUA 28-13.572 9.204 7. 696 1.00 0.00 N ATOM 2800 N1 GUA 28-12.165 10.261 9.188 1.00 0.00 N ATOM 2801 C6 GUA 28-11.600 11.338 9.858 1.00 0.00 C ATOM 2802 06 GUA 28-10.723 11.150 10.699 1.00 0.00 0 ATOM 2803 C5 GUA 28-12.165 12.571 9.433 1.00 0.00 C ATOM 2804 N7 GUA 28-11.883 13.877 9.846 1.00 0.00 N ATOM 2805 C8 GUA 28-12.698 14.565 9.117 1.00 0.00 C ATOM 2806 C2'GUA 28-15.908 13.910 7.684 1.00 0.00 C ATOM 2807 02'GUA 28-16.686 13.595 6.523 1.00 0.00 0 ATOM 2808 C3'GUA 28-16.463 15.114 8.419 1.00 0.00 C ATOM 2809 03'GUA 28-17.889 15.119 8.282 1.00 0.00 O ATOM 2810 1H5'GUA 28-15.497 18.359 7.743 1. 00 0. 00 H ATOM 2811 2H5'GUA 28-16.934 17.818 8.633 1.00 0. 00 H ATOM 2812 H4'GUA 28-16.451 16. 364 6. 677 1.00 0. 00 H ATOM 2813 Hl'GUA 28-14.264 14.036 6.301 1.00 0.00 H ATOM 2814 1H2 GUA 28-14.293 9.209 6.990 1.00 0.00 H ATOM 2815 2H2 GUA 28-13.168 8.331 7.999 1. 00 0. 00 H ATOM 2816 H1 GUA 28-11.808 9.350 9.435 1.00 0.00 H

ATOM 2817 H8 GUA 28-12.742 15.651 9.192 1.00 0.00 H ATOM 2818 H2'GUA 28-15.842 13.051 8.357 1.00 0.00 H ATOM 2819 H02'GUA 28-16.709 14.382 5.973 1.00 0.00 H ATOM 2820 H3'GUA 28-16.138 15.146 9.460 1.00 0.00 H ATOM 2821 P CYT 29-18.810 14.216 9.249 1.00 0.00 P ATOM 2822 01P CYT 29-20.227 14.554 8.986 1.00 0.00 O ATOM 2823 02P CYT 29-18.272 14.315 10.625 1.00 0.00 O ATOM 2824 05'CYT 29-18.537 12.722 8.710 1.00 0.00 0 ATOM 2825 C5'CYT 29-19.179 12.245 7.523 1.00 0.00 C ATOM 2826 C4'CYT 29-18.943 10.750 7.316 1.00 0.00 C ATOM 2827 04'CYT 29-17.546 10.445 7.208 1.00 0.00 O ATOM 2828 C1'CYT 29-17.248 9.260 7.972 1.00 0.00 C ATOM 2829 N1 CYT 29-16.409 9.575 9.151 1. 00 0.00 N ATOM 2830 C6 CYT 29-16.395 10.831 9.688 1.00 0.00 C ATOM 2831 C2 CYT 29-15.628 8.554 9.679 1.00 0.00 C ATOM 2832 02 CYT 29-15.662 7.428 9.185 1.00 0.00 O ATOM 2833 N3 CYT 29-14.838 8.835 10.751 1.00 0.00 N ATOM 2834 C4 CYT 29-14.812 10.063 11.285 1.00 0.00 C ATOM 2835 N4 CYT 29-14.022 10.306 12.329 1.00 0.00 N ATOM 2836 C5 CYT 29-15.616 11.116 10.747 1.00 0.00 C ATOM 2837 C2'CYT 29-18.594 8.685 8.392 1.00 0.00 C ATOM 2838 02'CYT 29-19.115 7.791 7.400 1.00 0.00 O ATOM 2839 C3'CYT 29-19.431 9.942 8.508 1.00 0.00 C ATOM 2840 03'CYT 29-20.807 9.601 8.302 1.00 0.00 0 ATOM 2841 1H5'CYT 29-18. 787 12.789 6.663 1.00 0.00 H ATOM 2842 2H5'CYT 29-20.251 12.427 7.601 1.00 0.00 H ATOM 2843 H4'CYT 29-19.455 10.418 6.414 1.00 0.00 H ATOM 2844 H1'CYT 29-16.728 8.542 7.337 1.00 0.00 H ATOM 2845 H6 CYT 29-17.023 11.609 9.255 1.00 0.00 H ATOM 2846 1H4 CYT 29-13.992 11.230 12.736 1.00 0.00 H ATOM 2847 2H4 CYT 29-13.448 9.567 12.711 1.00 0.00 H ATOM 2848 H5 CYT 29-15.598 12.116 11.180 1.00 0.00 H ATOM 2849 H2'CYT 29-18.510 8.192 9.362 1.00 0.00 H ATOM 2850 H02'CYT 29-18.617 6.972 7.466 1.00 0.00 H ATOM 2851 H3'CYT 29-19.263 10.460 9.454 1.00 0.00 H ATOM 2852 P CYT 30-21.710 9.063 9.523 1.00 0.00 P ATOM 2853 O1P CYT 30-23.085 8.849 9.021 1.00 0.00 0 ATOM 2854 02P CYT 30-21.481 9.942 10.692 1.00 0.00 O ATOM 2855 05'CYT 30-21.058 7.624 9.841 1.00 0. 00 O ATOM 2856 C5'CYT 30-21.273 6.515 8.962 1.00 0.00 C ATOM 2857 C4'CYT 30-20.383 5.328 9.325 1.00 0.00 C ATOM 2858 04'CYT 30-18.996 5.680 9.299 1.00 0.00 0 ATOM 2859 C1'CYT 30-18.320 5.030 10.391 1.00 0.00 C ATOM 2860 N1 CYT 30-17.793 6.015 11.362 1.00 0.00 N ATOM 2861 C6 CYT 30-18.443 7.194 11.596 1.00 0.00 C ATOM 2862 C2 CYT 30-16.610 5.700 12. 018 1.00 0.00 C ATOM 2863 02 CYT 30-16.047 4.629 11.801 1.00 0.00 0 ATOM 2864 N3 CYT 30-16.104 6.600 12.905 1.00 0.00 N ATOM 2865 C4 CYT 30-16.730 7.759 13.143 1.00 0.00 C ATOM 2866 N4 CYT 30-16.205 8.617 14.018 1.00 0.00 N ATOM 2867 C5 CYT 30-17.949 8.089 12.472 1.00 0.00 C ATOM 2868 C2'CYT 30-19.355 4.112 11.036 1.00 0. 00 C ATOM 2869 02'CYT 30-19.349 2.813 10.432 1.00 0.00 O ATOM 2870 C3'CYT 30-20. 642 4.856 10.745 1.00 0.00 C ATOM 2871 03'CYT 30-21.786 3.998 10. 825 1.00 0.00 O ATOM 2872 1H5'CYT 30-21.054 6.823 7.939 1.00 0.00 H ATOM 2873 2H5'CYT 30-22.317 6.209 9.025 1.00 0.00 H ATOM 2874 H4'CYT 30-20.560 4.510 8.629 1.00 0.00 H ATOM 2875 H1'CYT 30-17.498 4. 429 9.999 1.00 0.00 H ATOM 2876 H6 CYT 30-19. 372 7.412 11.070 1.00 0. 00 H

ATOM 2877 1H4 CYT 30-16.669 9.494 14.205 1.00 0.00 H ATOM 2878 2H4 CYT 30-15.348 8.385 14.500 1.00 0.00 H ATOM 2879 H5 CYT 30-18.461 9.032 12.664 1.00 0.00 H ATOM 2880 H2'CYT 30-19.186 4.047 12.114 1.00 0.00 H ATOM 2881 H02'CYT 30-19.327 2.940 9.481 1.00 0.00 H ATOM 2882 H3'CYT 30-20.741 5.713 11.418 1.00 0.00 H ATOM 2883 H03'CYT 30-21.591 3.215 10.305 1.00 0.00 H TER ATOM 2884 05'GUA 1 14.109-6. 671-15.597 1.00 0.00 O ATOM 2885 C5'GUA 1 13.162-5. 812-16.238 1.00 0.00 C ATOM 2886 C4'GUA 1 11.726-6. 241-15.947 1.00 0.00 C ATOM 2887 04'GUA 1 11.484-7. 591-16.376 1.00 0.00 0 ATOM 2888 Cl'GUA 1 10.833-8. 322-15.322 1.00 0.00 C ATOM 2889 N9 GUA 1 11.766-9. 258-14.663 1.00 0.00 N ATOM 2890 C4 GUA 1 11.434-10. 413-13.992 1.00 0.00 C ATOM 2891 N3 GUA 1 10.183-10. 892-13.808 1.00 0.00 N ATOM 2892 C2 GUA 1 10.177-12. 035-13.116 1.00 0.00 C ATOM 2893 N2 GUA 1 9.023-12. 640-12.838 1.00 0.00 N ATOM 2894 N1 GUA 1 11.319-12. 651-12.646 1.00 0.00 N ATOM 2895 C6 GUA 1 12.613-12. 179-12.820 1.00 0.00 C ATOM 2896 06 GUA 1 13.565-12. 803-12.359 1.00 0.00 0 ATOM 2897 C5 GUA 1 12.629-10. 964-13.554 1.00 0.00 C ATOM 2898 N7 GUA 1 13.710-10. 168-13.942 1.00 0.00 N ATOM 2899 C8 GUA 1 13.118-9. 211-14.573 1.00 0.00 C ATOM 2900 C2'GUA 1 10.337-7. 269-14.345 1.00 0.00 C ATOM 2901 02'GUA 1 9.070-6. 734-14.746 1.00 0.00 0 ATOM 2902 C3'GUA 1 11.443-6. 240-14.451 1.00 0.00 C ATOM 2903 03'GUA 1 10.918-4. 961-14.082 1.00 0.00 0 ATOM 2904 H5'GUA 1 14.984-6. 330-15.797 1.00 0.00 H ATOM 2905 1H5'GUA 1 13. 329-5. 838-17.315 1.00 0.00 H ATOM 2906 2H5'GUA 1 13.308-4. 792-15.880 1.00 0.00 H ATOM 2907 H4'GUA 1 11.032-5. 572-16.452 1.00 0.00 H ATOM 2908 Hl'GUA 1 9.985-8. 874-15.728 1.00 0.00 H ATOM 2909 1H2 GUA 1 8. 152-12.235-13. 150 1.00 0.00 H ATOM 2910 2H2 GUA 1 9.019-13. 507-12.319 1.00 0.00 H ATOM 2911 H1 GUA 1 11.230-13. 516-12.136 1.00 0.00 H ATOM 2912 H8 GUA 1 13.684-8. 390-15.011 1.00 0.00 H ATOM 2913 H2'GUA 1 10.291-7. 681-13.333 1.00 0.00 H ATOM 2914 H02'GUA 1 8.411-7. 415-14.590 1.00 0.00 H ATOM 2915 H3'GUA 1 12.320-6. 520-13.865 1.00 0.00 H,, ATOM 2916 P GUA 2 10.885-4. 507-12.537 1.00 0.00 P ATOM 2917 01P GUA 2 12.247-4. 663-11. 978 1.00 0.00 0 ATOM 2918 02P GUA 2 10.199-3. 198-12.453 1.00 0.00 0 ATOM 2919 05'GUA 2 9.935-5. 620-11. 865 1.00 0.00 0 ATOM 2920 C5'GUA 2 8.529-5. 627-12.128 1.00 0.00 C ATOM 2921 C4'GUA 2 7.845-6. 846-11.514 1.00 0.00 C ATOM 2922 04'GUA 2 8. 368-8.073-12. 034 1.00 0.00 0 ATOM 2923 Cl'GUA 2 8.385-9. 064-10.986 1.00 0.00 C ATOM 2924 N9 GUA 2 9.759-9. 542-10.723 1.00 0.00 N ATOM 2925 C4 GUA 2 10.114-10. 757-10.176 1.00 0.00 C ATOM 2926 N3 GUA 2 9.261-11. 727-9.776 1.00 0.00 N ATOM 2927 C2 GUA 2 9.902-12. 794-9.286 1.00 0.00 C ATOM 2928 N2 GUA 2 9.210-13. 843-8.844 1.00 0.00 N ATOM 2929 N1 GUA 2 11.277-12. 889-9.202 1.00 0. 00 N ATOM 2930 C6 GUA 2 12.172-11. 907-9.604 1.00 0.00 C ATOM 2931 06 GUA 2 13.381-12. 089-9.484 1.00 0.00 0 ATOM 2932 C5 GUA 2 11.500-10. 769-10.125 1.00 0.00 C ATOM 2933 N7 GUA 2 12.022-9. 577-10.634 1.00 0.00 N ATOM 2934 C8 GUA 2 10.950-8. 933-10.953 1.00 0.00 C ATOM 2935 C2'GUA 2 7.791-8. 388-9.750 1.00 0.00 C

ATOM 2936 02'GUA 2 6.380-8. 621-9.651 1.00 0.00 0 ATOM 2937 C3'GUA 2 8.099-6. 930-10.023 1.00 0.00 C ATOM 2938 03'GUA 2 7.138-6. 114-9.349 1.00 0.00 0 ATOM 2939 1H5'GUA 2 8.367-5. 635-13.206 1.00 0.00 H ATOM 2940 2H5'GUA 2 8.085-4. 724-11.708 1.00 0.00 H ATOM 2941 H4'GUA 2 6.774-6. 802-11.703 1.00 0.00 H ATOM 2942 H1'GUA 2 7.756-9. 906-11.275 1.00 0.00 H ATOM 2943 1H2 GUA 2 8.201-13. 833-8.878 1.00 0.00 H ATOM 2944 2H2 GUA 2 9.695-14. 651-8.478 1.00 0.00 H ATOM 2945 H1 GUA 2 11.685-13. 733-8.826 1.00 0.00 H ATOM 2946 H8 GUA 2 11.000-7. 937-11.393 1.00 0.00 H ATOM 2947 H2'GUA 2 8.309-8. 725-8.849 1.00 0.00 H ATOM 2948 H02'GUA 2 6.260-9. 538-9.393 1.00 0.00 H ATOM 2949 H3'GUA 2 9.128-6. 675-9.764 1.00 0.00 H ATOM 2950 P CYT 3 7.419-5. 590-7.853 1.00 0.00 P ATOM 2951 01P CYT 3 6.368-4. 609-7.500 1.00 0.00 0 ATOM 2952 02P CYT 3 8.847-5. 211-7.753 1.00 0.00 O ATOM 2953 05'CYT 3 7.189-6. 918-6.974 1.00 0.00 O ATOM 2954 C5'CYT 3 5.868-7. 393-6.706 1.00 0.00 C ATOM 2955 C4'CYT 3 5.894-8. 702-5.924 1.00 0.00 C ATOM 2956 04'CYT 3 6.494-9. 762-6.681 1.00 0.00 0 ATOM 2957 C1'CYT 3 7.378-10. 517-5.830 1.00 0.00 C ATOM 2958 N1 CYT 3 8.795-10. 309-6.209 1.00 0.00 N ATOM 2959 C6 CYT 3 9.242-9. 083-6.612 1.00 0.00 C ATOM 2960 C2 CYT 3 9.648-11. 402-6.137 1.00 0.00 C ATOM 2961 02 CYT 3 9.223-12. 496-5.770 1.00 0.00 0 ATOM 2962 N3 CYT 3 10.954-11. 225-6.480 1.00 0.00 N ATOM 2963 C4 CYT 3 11.405-10. 027-6.876 1.00 0.00 C ATOM 2964 N4 CYT 3 12.688-9. 889-7.208 1.00 0.00 N ATOM 2965 C5 CYT 3 10.529-8. 899-6.951 1.00 0.00 C ATOM 2966 C2'CYT 3 7.109-10. 023-4.412 1.00 0.00 C ATOM 2967 02'CYT 3 6.026-10. 736-3. 802 1.00 0.00 0 ATOM 2968 C3'CYT 3 6.751-8. 577-4.677 1.00 0.00 C ATOM 2969 03'CYT 3 5.937-8. 090-3.606 1.00 0. 00 0 ATOM 2970 1H5'CYT 3 5.345-7. 552-7.650 1.00 0.00 H ATOM 2971 2H5'CYT 3 5.332-6. 643-6.124 1.00 0.00 H ATOM 2972 H4'CYT 3 4.880-8. 986-5.646 1.00 0.00 H ATOM 2973 H1'CYT 3 7.132-11. 578-5.900 1.00 0.00 H ATOM 2974 H6 CYT 3 8.547-8. 246-6.668 1.00 0.00 H ATOM 2975 1H4 CYT 3 13.037-8. 991-7.511 1.00 0.00 H ATOM 2976 2H4 CYT 3 13.313-10. 681-7.154 1.00 0.00 H ATOM 2977 H5 CYT 3 10.892-7. 922-7.264 1.00 0.00 H ATOM 2978 H2'CYT 3 8.017-10. 090-3.808 1.00 0.00 H ATOM 2979 H02'CYT 3 6.333-11. 631-3.634 1.00 0.00 H ATOM 2980 H3'CYT 3 7.638-7. 961-4.848 1.00 0.00 H ATOM 2981 P GUA 4 6.556-7. 104-2.495 1.00 0.00 P ATOM 2982 01P GUA 4 7.439-6. 131-3.178 1.00 0.00 0 ATOM 2983 02P GUA 4 5.452-6. 622-1.635 1.00 0. 00 0 ATOM 2984 05'GUA 4 7.478-8. 096-1.626 1.00 0.00 0 ATOM 2985 C5'GUA 4 6.883-9. 085-0.783 1.00 0.00 C ATOM 2986 C4'GUA 4 7. 884-10. 167-0. 388 1.00 0.00 C ATOM 2987 04'GUA 4 8.421-10. 838-1.529 1. 00 0.00 0 ATOM 2988 C1'GUA 4 9.782-11. 225-1.251 1.00 0.00 C ATOM 2989 N9 GUA 4 10.718-10. 668-2.249 1. 00 0.00 N ATOM 2990 C4 GUA 4 12.000-11. 104-2.494 1.00 0.00 C ATOM 2991 N3 GUA 4 12.625-12. 115-1. 852 1.00 0.00 N ATOM 2992 C2 GUA 4 13.866-12. 309-2.303 1.00 0.00 C ATOM 2993 N2 GUA 4 14.623-13. 266-1.770 1.00 0.00 N ATOM 2994 N1 GUA 4 14.441-11. 561-3.311 1.00 0.00 N ATOM 2995 C6 GUA 4 13.820-10. 518-3.986 1.00 0.00 C

ATOM 2996 06 GUA 4 14.419-9. 916-4.875 1.00 0.00 O ATOM 2997 C5 GUA 4 12.498-10. 304-3.510 1.00 0.00 C ATOM 2998 N7 GUA 4 11.541-9. 365-3.908 1.00 0.00 N ATOM 2999 C8 GUA 4 10.552-9. 649-3.129 1.00 0.00 C ATOM 3000 C2'GUA 4 10.103-10. 702 0.150 1.00 0.00 C ATOM 3001 02'GUA 4 9.913-11. 718 1.143 1.00 0.00 O ATOM 3002 C3'GUA 4 9.097-9. 578 0.302 1.00 0.00 C ATOM 3003 03'GUA 4 8.800-9. 406 1.690 1.00 0.00 0 ATOM 3004 1H5'GUA 4 6. 049-9. 549-1.309 1.00 0.00 H ATOM 3005 2H5'GUA 4 6.509-8. 602 0.120 1.00 0.00 H ATOM 3006 H4'GUA 4 7.404-10. 894 0.266 1.00 0.00 H ATOM 3007 H1'GUA 4 9.855-12. 313-1.255 1.00 0.00 H ATOM 3008 1H2 GUA 4 14.257-13. 843-1.026 1.00 0.00 H ATOM 3009 2H2 GUA 4 15.561-13. 412-2. 107 1.00 0.00 H ATOM 3010 H1 GUA 4 15.387-11. 771-3.595 1.00 0.00 H ATOM 3011 H8 GUA 4 9.620-9. 086-3.171 1.00 0.00 H ATOM 3012 H2'GUA 4 11.122-10. 307 0.182 1.00 0.00 H ATOM 3013 H02'GUA 4 9.014-12. 041 1.053 1.00 0.00 H ATOM 3014 H3'GUA 4 9.436-8. 657-0.175 1.00 0.00 H ATOM 3015 P CYT 5 9.781-8. 546 2.633 1. 00 0.00 P ATOM 3016 01P CYT 5 10.174-7. 322 1.899 1.00 0.00 0 ATOM 3017 02P CYT 5 9.157-8. 434 3.971 1.00 0.00 0 ATOM 3018 05'CYT 5 11.074-9. 498 2.755 1.00 0.00 O ATOM 3019 C5'CYT 5 11.077-10. 611 3.654 1.00 0.00 C ATOM 3020 C4'CYT 5 12.469-11. 221 3.786 1.00 0.00 C ATOM 3021 04'CYT 5 12.930-11. 771 2.548 1.00 0.00 0 ATOM 3022 C1'CYT 5 14.341-11. 515 2.403 1.00 0.00 C ATOM 3023 N1 CYT 5 14.613-10. 666 1.220 1.00 0.00 N ATOM 3024 C6 CYT 5 13.739-9. 688 0.838 1.00 0.00 C ATOM 3025 C2 CYT 5 15.786-10. 905 0.513 1.00 0.00 C ATOM 3026 02 CYT 5 16.559-11. 790 0.875 1.00 0.00 0 ATOM 3027 N3 CYT 5 16.048-10. 137-0.580 1.00 0.00 N ATOM 3028 C4 CYT 5 15.199-9. 176-0.966 1.00 0.00 C ATOM 3029 N4 CYT 5 15.489-8. 444-2.041 1.00 0.00 N ATOM 3030 C5 CYT 5 13.992-8. 925-0.242 1.00 0.00 C ATOM 3031 C2'CYT 5 14.785-10. 825 3.694 1.00 0.00 C ATOM 3032 02'CYT 5 15.262-11. 772 4.658 1.00 0.00 0 ATOM 3033 C3'CYT 5 13.497-10. 166 4.145 1.00 0.00 C ATOM 3034 03'CYT 5 13.522-10. 019 5.568 1.00 0.00 0 ATOM 3035 1H5'CYT 5 10.389-11. 371 3.285 1.00 0.00 H ATOM 3036 2H5'CYT 5 10.743-10. 274 4.636 1.00 0.00 H ATOM 3037 H4'CYT 5 12.460-12. 000 4.547 1.00 0.00 H ATOM 3038 H1'CYT 5 14.871-12. 462 2.300 1.00 0.00 H ATOM 3039 H6 CYT 5 12.827-9. 524 1.413 1.00 0.00 H ATOM 3040 1H4 CYT 5 16.340-8. 617-2.555 1.00 0.00 H ATOM 3041 2H4 CYT 5 14. 857-7. 715-2.342 1.00 0.00 H ATOM 3042 H5 CYT 5 13.299-8. 144-0.555 1.00 0.00 H ATOM 3043 H2'CYT 5 15.544-10. 070 3.477 1.00 0.00 H ATOM 3044 H02'CYT 5 16.125-12. 071 4.363 1.00 0.00 H ATOM 3045 H3'CYT 5 13.317-9. 223 3.627 1.00 0.00 H ATOM 3046 P URI 6 14.008-8. 637 6.235 1.00 0.00 P ATOM 3047 O1P URI 6 13.801-8. 730 7.697 1.00 0.00 O ATOM 3048 02P URI 6 13.408-7. 518 5.474 1.00 0.00 O ATOM 3049 05'URI 6 15.591-8. 651 5. 945 1. 00 0.00 0 ATOM 3050 C5'URI 6 16.454-9. 530 6.672 1.00 0.00 C ATOM 3051 C4'URI 6 17.880-9. 491 6.132 1.00 0.00 C ATOM 3052 04'URI 6 17.947-9. 933 4.770 1. 00 0. 00 0 ATOM 3053 C1'URI 6 18.880-9. 105 4.045 1.00 0.00 C ATOM 3054 N1 URI 6 18.196-8. 307 3.000 1.00 0.00 N ATOM 3055 C6 URI 6 16.922-7. 839 3.187 1.00 0.00 C

ATOM 3056 C2 URI 6 18.892-8. 055 1.830 1.00 0.00 C ATOM 3057 02 URI 6 20. 038-8. 460 1.647 1.00 0.00 O ATOM 3058 N3 URI 6 18.225-7. 312 0.874 1.00 0.00 N ATOM 3059 C4 URI 6 16.942-6. 805 0.981 1.00 0.00 C ATOM 3060 04 URI 6 16.446-6. 158 0.061 1.00 0. 00 0 ATOM 3061 C5 URI 6 16.290-7. 112 2.233 1.00 0.00 C ATOM 3062 C2'URI 6 19.533-8. 204 5.087 1.00 0.00 C ATOM 3063 02'URI 6 20. 697-8. 816 5.656 1.00 0.00 0 ATOM 3064 C3'URI 6 18.417-8. 073 6.100 1.00 0.00 C ATOM 3065 03'URI 6 18.981-7. 759 7.376 1.00 0.00 0 ATOM 3066 1H5'URI 6 16.072-10. 549 6.596 1.00 0.00 H ATOM 3067 2H5'URI 6 16.463-9. 231 7.720 1.00 0.00 H ATOM 3068 H4'URI 6 18.525-10. 115 6.747 1.00 0.00 H ATOM 3069 H1'URI 6 19. 641-9. 734 3.583 1.00 0. 00 H ATOM 3070 H6 URI 6 16.407-8. 053 4.122 1.00 0.00 H ATOM 3071 H3 URI 6 18.721-7. 122 0.015 1.00 0.00 H ATOM 3072 H5 URI 6 15.277-6. 754 2.414 1.00 0.00 H ATOM 3073 H2'URI 6 19.771-7. 233 4.651 1.00 0.00 H ATOM 3074 H02'URI 6 21.422-8. 677 5.041 1.00 0.00 H ATOM 3075 H3'URI 6 17.661-7. 352 5.784 1.00 0.00 H ATOM 3076 P CYT 7 19.187-6. 223 7.819 1.00 0.00 P ATOM 3077 O1P CYT 7 17.996-5. 454 7.393 1.00 0.00 0 ATOM 3078 02P CYT 7 19.611-6. 203 9.237 1.00 0.00 0 ATOM 3079 05'CYT 7 20.434-5. 762 6.910 1.00 0.00 0 ATOM 3080 C5'CYT 7 21.733-6. 321 7.126 1.00 0.00 C ATOM 3081 C4'CYT 7 22.648-6. 109 5.924 1.00 0.00 C ATOM 3082 04'CYT 7 22.079-6. 634 4.720 1.00 0.00 0 ATOM 3083 C1'CYT 7 22.460-5. 793 3.612 1.00 0.00 C ATOM 3084 N1 CYT 7 21.283-5. 198 2.938 1.00 0.00 N ATOM 3085 C6 CYT 7 20.097-5. 030 3.594 1.00 0.00 C ATOM 3086 C2 CYT 7 21.441-4. 805 1.617 1.00 0.00 C ATOM 3087 02 CYT 7 22.519-4. 965 1.049 1.00 0.00 0 ATOM 3088 N3 CYT 7 20.381-4. 240 0.980 1.00 0.00 N ATOM 3089 C4 CYT 7 19.213-4. 068 1.608 1.00 0.00 C ATOM 3090 N4 CYT 7 18.197-3. 510 0.952 1.00 0.00 N ATOM 3091 C5 CYT 7 19.042-4. 472 2.970 1.00 0.00 C ATOM 3092 C2'CYT 7 23.354-4. 701 4.197 1.00 0.00 C ATOM 3093 02'CYT 7 24.738-5. 070 4.137 1.00 0.00 0 ATOM 3094 C3'CYT 7 22.852-4. 638 5.624 1.00 0. 00 C ATOM 3095 03'CYT 7 23.898-4. 129 6.459 1.00 0.00 0 ATOM 3096 1H5'CYT 7 21.633-7. 391 7.311 1.00 0.00 H ATOM 3097 2H5'CYT 7 22.181-5. 850 8. 002 1.00 0.00 H ATOM 3098 H4'CYT 7 23.611-6. 586 6.104 1.00 0.00 H ATOM 3099 H1'CYT 7 23. 032-6. 381 2.893 1.00 0. 00 H ATOM 3100 H6 CYT 7 20.002-5. 348 4.632 1.00 0.00 H ATOM 3101 1H4 CYT 7 17.310-3. 374 1.415 1.00 0. 00 H ATOM 3102 2H4 CYT 7 18.316-3. 221-0.009 1.00 0.00 H ATOM 3103 H5 CYT 7 18.091-4. 333 3.485 1.00 0.00 H ATOM 3104 H2'CYT 7 23.177-3. 752 3.685 1.00 0.00 H ATOM 3105 H02'CYT 7 24. 992-5. 073 3.212 1.00 0.00 H ATOM 3106 H3'CYT 7 21.926-4. 067 5.709 1.00 0.00 H ATOM 3107 P ADE 8 24. 034-2. 544 6.719 1.00 0. 00 P ATOM 3108 O1P ADE 8 22.749-2. 053 7.264 1.00 0.00 0 ATOM 3109 02P ADE 8 25.291-2. 302 7.461 1.00 0.00 0 ATOM 3110 05'ADE 8 24.205-1. 957 5.228 1.00 0.00 0 ATOM 3111 C5'ADE 8 25. 394-2.213 4.474 1.00 0.00 C ATOM 3112 C4'ADE 8 25. 284-1. 676 3.048 1.00 0.00 C ATOM 3113 04'ADE 8 24.196-2. 284 2.332 1. 00 0.00 0 ATOM 3114 C1'ADE 8 23.450-1. 262 1.640 1.00 0.00 C ATOM 3115 N9 ADE 8 22. 146-1. 017 2.290 1.00 0. 00 N

ATOM 3116 C4 ADE 8 21.076-0. 325 1.763 1.00 0.00 C ATOM 3117 N3 ADE 8 21.018 0.263 0.550 1.00 0.00 N ATOM 3118 C2 ADE 8 19.839 0.849 0.351 1.00 0.00 C ATOM 3119 N1 ADE 8 18. 807 0.888 1.194 1.00 0.00 N ATOM 3120 C6 ADE 8 18.887 0.294 2.397 1.00 0.00 C ATOM 3121 N6 ADE 8 17.842 0.344 3.222 1.00 0.00 N ATOM 3122 C5 ADE 8 20.084-0. 355 2.717 1.00 0. 00 C ATOM 3123 N7 ADE 8 20. 505-1. 057 3.850 1.00 0.00 N ATOM 3124 C8 ADE 8 21.703-1. 400 3.514 1.00 0.00 C ATOM 3125 C2'ADE 8 24.328-0. 022 1.683 1.00 0.00 C ATOM 3126 02'ADE 8 25.301-0. 027 0.632 1.00 0.00 0 ATOM 3127 C3'ADE 8 24. 969-0.188 3.042 1.00 0.00 C ATOM 3128 03'ADE 8 26.191 0.553 3.076 1.00 0.00 0 ATOM 3129 1H5'ADE 8 25.569-3. 288 4.436 1.00 0.00 H ATOM 3130 2H5'ADE 8 26.239-1. 733 4.970 1.00 0.00 H ATOM 3131 H4'ADE 8 26.214-1. 857 2.513 1.00 0.00 H ATOM 3132 H1'ADE 8 23.294-1. 559 0.606 1.00 0.00 H ATOM 3133 H2 ADE 8 19.703 1.357-0. 604 1.00 0.00 H ATOM 3134 1H6 ADE 8 17.000 0.826 2.942 1.00 0.00 H ATOM 3135 2H6 ADE 8 17.893-0. 101 4.128 1.00 0.00 H ATOM 3136 H8 ADE 8 22.337-1. 972 4.191 1.00 0.00 H ATOM 3137 H2'ADE 8 23. 713 0.881 1.653 1.00 0. 00 H ATOM 3138 H02'ADE 8 25.976 0.614 0.866 1.00 0.00 H ATOM 3139 H3'ADE 8 24. 288 0.087 3.845 1.00 0.00 H ATOM 3140 P ADE 9 26.790 1.070 4.480 1.00 0.00 P ATOM 3141 O1P ADE 9 27.633 2. 257 4.213 1.00 0.00 0 ATOM 3142 02P ADE 9 27.359-0. 092 5.199 1.00 0.00 O ATOM 3143 05'ADE 9 25.470 1.556 5.270 1.00 0.00 0 ATOM 3144 C5'ADE 9 25.577 2.169 6.560 1.00 0.00 C ATOM 3145 C4'ADE 9 24.209 2.555 7.128 1.00 0.00 C ATOM 3146 04'ADE 9 23.477 3. 378 6.215 1.00 0.00 0 ATOM 3147 C1'ADE 9 22.414 2.619 5.613 1.00 0.00 C ATOM 3148 N9 ADE 9 22.421 2. 790 4.148 1.00 0.00 N ATOM 3149 C4 ADE 9 21.363 3.177 3.359 1.00 0.00 C ATOM 3150 N3 ADE 9 20.113 3.445 3.777 1.00 0.00 N ATOM 3151 C2 ADE 9 19.331 3.796 2.764 1.00 0.00 C ATOM 3152 N1 ADE 9 19.669 3.891 1. 477 1.00 0.00 N ATOM 3153 C6 ADE 9 20. 924 3.618 1.083 1.00 0.00 C ATOM 3154 N6 ADE 9 21.244 3.724-0. 207 1.00 0.00 N ATOM 3155 C5 ADE 9 21.839 3. 238 2.069 1.00 0.00 C ATOM 3156 N7 ADE 9 23.191 2.891 2.023 1.00 0.00 N ATOM 3157 C8 ADE 9 23.438 2.650 3. 266 1.00 0.00 C ATOM 3158 C2'ADE 9 22.656 1.165 6.009 1.00 0.00 C ATOM 3159 02'ADE 9 21.429 0.433 6.113 1.00 0.00 0 ATOM 3160 C3'ADE 9 23.327 1.329 7.358 1.00 0.00 C ATOM 3161 03'ADE 9 22.307 1.643 8.324 1.00 0.00 0 ATOM 3162 lH5'ADE 9 26.189 3.068 6.474 1.00 0.00 H ATOM 3163 2H5'ADE 9 26.063 1. 474 7.245 1.00 0.00 H ATOM 3164 H4'ADE 9 24.347 3.093 8.063 1.00 0.00 H ATOM 3165 Hl'ADE 9 21.455 2.950 6.013 1.00 0.00 H ATOM 3166 H2 ADE 9 18.303 4.040 3.013 1.00 0.00 H ATOM 3167 1H6 ADE 9 22.186 3.524-0. 512 1.00 0.00 H ATOM 3168 2H6 ADE 9 20.544 4.005-0. 879 1.00 0.00 H ATOM 3169 H8 ADE 9 24.429 2.348 3.596 1.00 0.00 H ATOM 3170 H2'ADE 9 23.342 0.691 5.306 1.00 0.00 H ATOM 3171 H02'ADE 9 21.088 0.317 5.223 1.00 0.00 H ATOM 3172 H3'ADE 9 23.909 0.451 7.638 1.00 0.00 H ATOM 3173 P URI 10 22. 646 2.407 9.704 1.00 0.00 P ATOM 3174 01P URI 10 21.458 2. 327 10.583 1.00 0.00 0 ATOM 3175 02P URI 10 23.959 1.928 10.192 1. 00 0.00 0

ATOM 3176 05'URI 10 22.814 3.932 9. 214 1.00 0.00 O ATOM 3177 C5'URI 10 22.446 5.027 10.056 1.00 0.00 C ATOM 3178 C4'URI 10 21.357 5.879 9.409 1.00 0.00 C ATOM 3179 04'URI 10 20.122 5.153 9.294 1.00 0.00 O ATOM 3180 C1'URI 10 19.121 5.755 10.134 1.00 0.00 C ATOM 3181 N1 URI 10 18.318 4.728 10.838 1.00 0.00 N ATOM 3182 C6 URI 10 18.710 3.415 10.857 1.00 0.00 C ATOM 3183 C2 URI 10 17.162 5.144 11.479 1.00 0.00 C ATOM 3184 02 URI 10 16.788 6.316 11.468 1.00 0.00 0 ATOM 3185 N3 URI 10 16.442 4.160 12.132 1.00 0.00 N ATOM 3186 C4 URI 10 16.768 2.818 12.200 1.00 0.00 C ATOM 3187 04 URI 10 16.051 2.029 12.812 1.00 0.00 0 ATOM 3188 C5 URI 10 17.986 2.472 11.504 1.00 0.00 C ATOM 3189 C2'URI 10 19.890 6.625 11.119 1.00 0.00 C ATOM 3190 02'URI 10 19.096 7.716 11.598 1.00 0.00 O ATOM 3191 C3'URI 10 21.039 7.106 10.254 1.00 0.00 C ATOM 3192 03'URI 10 20.554 8.137 9.385 1.00 0.00 O ATOM 3193 1H5'URI 10 23.324 5.648 10.233 1.00 0.00 H ATOM 3194 2H5'. URI 10 22.083 4.644 11.010 1.00 0.00 H ATOM 3195 H4'URI 10 21.681 6.192 8.419 1.00 0.00 H ATOM 3196 H1'URI 10 18.465 6.382 9.530 1.00 0.00 H ATOM 3197 H6 URI 10 19.620 3.123 10.335 1.00 0.00 H ATOM 3198 H3 URI 10 15.597 4.450 12.604 1.00 0.00 H ATOM 3199 H5 URI 10 18.327 1.437 11.499 1.00 0.00 H ATOM 3200 H2'URI 10 20.271 6.017 11.945 1.00 0.00 H ATOM 3201 H02'URI 10 18.771 8.191 10.830 1.00 0.00 H ATOM 3202 H3'URI 10 21.895 7.431 10.847 1.00 0.00 H ATOM 3203 P GUA 11 21.577 9.061 8. 547 1.00 0.00 P ATOM 3204 01P GUA 11 22.635 9.534 9.468 1.00 0.00 0 ATOM 3205 02P GUA 11 20.783 10.041 7.773 1.00 0.00 O ATOM 3206 05'GUA 11 22.236 8.017 7.507 1.00 0.00 0 ATOM 3207 C5'GUA 11 23.638 7.720 7.553 1.00 0.00 C ATOM 3208 C4'GUA 11 24.144 7.166 6.222 1.00 0.00 C ATOM 3209 04'GUA 11 23.445 5.968 5.845 1.00 0.00 0 ATOM 3210 C1'GUA 11 23.005 6.082 4.480 1.00 0.00 C ATOM 3211 N9 GUA 11 21.567 6.388 4.411 1.00 0.00 N ATOM 3212 C4 GUA 11 20.827 6.592 3.273 1.00 0.00 C ATOM 3213 N3 GUA 11 21.294 6.541 2.007 1.00 0.00 N ATOM 3214 C2 GUA 11 20.338 6.783 1.108 1. 00 0. 00 C ATOM 3215 N2 GUA 11 20.627 6.769-0. 193 1.00 0.00 N ATOM 3216 N1 GUA 11 19.027 7.054 1.440 1.00 0.00 N ATOM 3217 C6 GUA 11 18.523 7.113 2.733 1.00 0.00 C ATOM 3218 06 GUA 11 17.337 7.366 2.921 1.00 0.00 0 ATOM 3219 C5 GUA 11 19.533 6.856 3.695 1.00 0.00 C ATOM 3220 N7 GUA 11 19.455 6.819 5.091 1.00 0.00 N ATOM 3221 C8 GUA 11 20.674 6.543 5.412 1.00 0.00 C ATOM 3222 C2'GUA 11 23.827 7.216 3.891 1.00 0.00 C ATOM 3223 02'GUA 11 25.128 6.773 3.486 1.00 0.00 0 ATOM 3224 C3'GUA 11 23. 893 8.146 5.084 1.00 0.00 C ATOM 3225 03'GUA 11 25.032 8.998 4.947 1.00 0.00 O ATOM 3226 1H5'GUA 11 23.820 6.984 8.336 1.00 0.00 H ATOM 3227 2H5'GUA 11 24.187 8.633 7.789 1.00 0.00 H ATOM 3228 H4'GUA 11 25.209 6.954 6.294 1. 00 0.00 H ATOM 3229 H1'GUA 11 23. 207 5.155 3.944 1.00 0.00 H ATOM 3230 1H2 GUA 11 19.904 6.952-0. 874 1.00 0.00 H ATOM 3231 2H2 GUA 11 21. 570 6.576-0. 498 1.00 0.00 H ATOM 3232 H1 GUA 11 18. 364 7.227 0.700 1.00 0. 00 H ATOM 3233 H8 GUA 11 20.978 6.442 6.451 1.00 0.00 H ATOM 3234 H2'GUA 11 23. 291 7.688 3.063 1.00 0. 00 H ATOM 3235 H02'GUA 11 25. 013 6.227 2.705 1.00 0.00 H

ATOM 3236 H3'GUA 11 22.963 8.702 5.219 1.00 0.00 H ATOM 3237 P CYT 12 24.843 10.534 4.506 1.00 0.00 P ATOM 3238 01P CYT 12 23.780 11.129 5.347 1.00 0.00 0 ATOM 3239 02P CYT 12 26.179 11.167 4.449 1.00 0.00 O ATOM 3240 05'CYT 12 24.280 10.400 3. 003 1.00 0.00 0 ATOM 3241 C5'CYT 12 25.131 9.940 1.950 1.00 0.00 C ATOM 3242 C4'CYT 12 24.395 9.875 0.615 1.00 0.00 C ATOM 3243 04'CYT 12 23. 279 8.979 0.664 1.00 0.00 O ATOM 3244 C1'CYT 12 22.182 9. 538-0. 0B9 1.00 0.00 C ATOM 3245 N1 CYT 12 21.024 9.839 0.787 1.00 0.00 N ATOM 3246 C6 CYT 12 21.132 9.768 2.148 1.00 0.00 C ATOM 3247 C2 CYT 12 19.817 10.161 0.174 1.00 0.00 C ATOM 3248 02 CYT 12 19.745 10.240-1. 051 1.00 0.00 O ATOM 3249 N3 CYT 12 18.735 10.397 0.965 1.00 0.00 N ATOM 3250 C4 CYT 12 18.827 10.325 2.299 1.00 0.00 C ATOM 3251 N4 CYT 12 17.742 10.540 3.043 1.00 0.00 N ATOM 3252 C5 CYT 12 20.067 10.002 2.935 1.00 0.00 C ATOM 3253 C2'CYT 12 22.728 10.802-0. 747 1.00 0.00 C ATOM 3254 02'CYT 12 23.289 10.519-2. 035 1.00 0.00 0 ATOM 3255 C3'CYT 12 23.793 11.219 0.246 1.00 0.00 C ATOM 3256 03'CYT 12 24.785 11.996-0. 432 1. 00 0.00 0 ATOM 3257 1H5'CYT 12 25.501 8.945 2.199 1.00 0.00 H ATOM 3258 2H5'CYT 12 25.978 10.620 1.855 1.00 0.00 H ATOM 3259 H4'CYT 12 25.080 9.554-0. 168 1.00 0.00 H ATOM 3260 H1'CYT 12 21. 879 8. 832-0. 862 1.00 0.00 H ATOM 3261 H6 CYT 12 22. 091 9. 517 2.601 1.00 0.00 H ATOM 3262 1H4 CYT 12 17.799 10.477 4.049 1.00 0.00 H ATOM 3263 2H4 CYT 12 16.861 10.759 2.599 1.00 0.00 H ATOM 3264 H5 CYT 12 20.146 9.950 4.020 1.00 0.00 H ATOM 3265 H2'CYT 12 21.948 11.561-0. 816 1.00 0.00 H ATOM 3266 H02'CYT 12 23.854 9.750-1. 935 1.00 0. 00 H ATOM 3267 H3'CYT 12 23.367 11.734 1.109 1.00 0.00 H ATOM 3268 P URI 13 24.702 13. 604-0. 437 1.00 0.00 P ATOM 3269 01P URI 13 24.341 14.054 0.926 1.00 0.00 O ATOM 3270 02P URI 13 25. 922 14. 130-1. 090 1.00 0.00 O ATOM 3271 05'URI 13 23.448 13.883-1. 406 1.00 0.00 0 ATOM 3272 C5'URI 13 23.523 13.574-2. 800 1.00 0.00 C ATOM 3273 C4'URI 13 22.157 13.684-3. 469 1.00 0.00 C ATOM 3274 04'URI 13 21.213 12.771-2. 898 1.00 0.00 O ATOM 3275 C1'URI 13 19.927 13.414-2. 794 1.00 0.00 C ATOM 3276 N1 URI 13 19.505 13.560-1. 381 1.00 0.00 N ATOM 3277 C6 URI 13 20.414 13.496-0. 356 1.00 0.00 C ATOM 3278 C2 URI 13 18.155 13.738-1. 134 1.00 0.00 C ATOM 3279 02 URI 13 17.326 13.816-2. 039 1.00 0.00 0 ATOM 3280 N3 URI 13 17.787 13.836 0.194 1.00 0.00 N ATOM 3281 C4 URI 13 18.636 13.775 1.284 1.00 0.00 C ATOM 3282 04 URI 13 18.193 13.858 2.427 1.00 0.00 O ATOM 3283 C5 URI 13 20.027 13. 594 0.938 1.00 0.00 C ATOM 3284 C2'URI 13 20.077 14.774-3. 469 1.00 0.00 C ATOM 3285 02'URI 13 19.750 14.708-4. 863 1.00 0.00 0 ATOM 3286 C3'URI 13 21.548 15. 056-3. 251 1.00 0.00 C ATOM 3287 03'URI 13 22.011 15.934-4. 282 1.00 0.00 0 ATOM 3288 1H5'URI 13 23.897 12.557-2. 922 1.00 0.00 H ATOM 3289 2H5'URI 13 24.212 14.267-3. 282 1.00 0.00 H ATOM 3290 H4'URI 13 22.250 13.488-4. 536 1.00 0.00 H ATOM 3291 H1'URI 13 19.185 12.823-3. 334 1.00 0.00 H ATOM 3292 H6 URI 13 21.471 13. 373-0. 586 1. 00 0.00 H ATOM 3293 H3 URI 13 16.806 13.969 0.386 1.00 0.00 H ATOM 3294 H5 URI 13 20.774 13. 536 1.729 1.00 0.00 H ATOM 3295 H2'URI 13 19.465 15-519-2-. 957 1.00 0.00 H

ATOM 3296 H02'URI 13 18.797 14.607-4. 928 1.00 0.00 H ATOM 3297 H3'URI 13 21. 747 15.440-2. 249 1.00 0.00 H ATOM 3298 P CYT 14 21.984 17. 529-4. 065 1.00 0.00 P ATOM 3299 O1P CYT 14 22.449 17.817-2. 689 1.00 0.00 0 ATOM 3300 02P CYT 14 22.658 18.165-5. 220 1.00 0.00 0 ATOM 3301 05'CYT 14 20.412 17. 866-4. 146 1. 00 0.00 0 ATOM 3302 C5'CYT 14 19.721 17.817-5. 398 1.00 0.00 C ATOM 3303 C4'CYT 14 18.214 17.972-5. 212 1.00 0.00 C ATOM 3304 04'CYT 14 17.673 16.926-4. 399 1.00 0.00 O ATOM 3305 C1'CYT 14 16. 664 17.468-3. 524 1.00 0.00 C ATOM 3306 N1 CYT 14 17. 050 17.332-2. 102 1.00 0.00 N ATOM 3307 C6 CYT 14 18.361 17.333-1. 724 1.00 0.00 C ATOM 3308 C2 CYT 14 16.028 17.211-1. 170 1.00 0.00 C ATOM 3309 02 CYT 14 14.853 17.222-1. 533 1.00 0.00 O ATOM 3310 N3 CYT 14 16. 363 17.090 0.143 1.00 0.00 N ATOM 3311 C4 CYT 14 17.645 17.090 0. 528 1.00 0.00 C ATOM 3312 N4 CYT 14 17.937 16.968 1.821 1.00 0.00 N ATOM 3313 C5 CYT 14 18. 700 17.216-0. 428 1.00 0.00 C ATOM 3314 C2'CYT 14 16.511 18. 937-3. 905 1.00 0.00 C ATOM 3315 02'CYT 14 15. 480 19.121-4. 883 1.00 0.00 O ATOM 3316 C3'CYT 14 17.881 19.253-4. 469 1.00 0.00 C ATOM 3317 03'CYT 14 17.753 20.315-5. 420 1. 00 0.00 O ATOM 3318 lH5'CYT 14 19. 923 16. 860-5. 880 1.00 0.00 H ATOM 3319 2H5'CYT 14 20.085 18. 621-6. 037 1.00 0.00 H ATOM 3320 H4'CYT 14 17.720 17.970-6. 182 1.00 0.00 H ATOM 3321 H1'CYT 14 15.720 16.949-3. 695 1.00 0.00 H ATOM 3322 H6 CYT 14 19.143 17.427-2. 478 1.00 0.00 H ATOM 3323 1H4 CYT 14 18. 901 16.964 2.124 1.00 0.00 H ATOM 3324 2H4 CYT 14 17.194 16.884 2.500 1.00 0.00 H ATOM 3325 H5 CYT 14 19. 743 17.224-0. 118 1.00 0.00 H ATOM 3326 H2'CYT 14 16. 320 19. 538-3. 013 1.00 0.00 H ATOM 3327 H02'CYT 14 15.693 18.559-5. 632 1.00 0.00 H ATOM 3328 H3'CYT 14 18. 606 19.475-3. 684 1.00 0.00 H ATOM 3329 P URI 15 17. 898 21.850-4. 953 1.00 0.00 P ATOM 3330 01P URI 15 17.585 22. 718-6. 111 1.00 0.00 0 ATOM 3331 02P URI 15 19.191 22.000-4. 248 1.00 0.00 0 ATOM 3332 05'URI 15 16.714 22.002-3. 872 1.00 0.00 0 ATOM 3333 C5'URI 15 15.348 22.088-4. 291 1.00 0.00 C ATOM 3334 C4'URI 15 14.391 22.063-3. 101 1. 00 0.00 C ATOM 3335 04'URI 15 14.499 20.842-2. 355 1.00 0.00 0 ATOM 3336 C1'URI 15 14.487 21.138-0. 944 1.00 0.00 C ATOM 3337 N1 URI 15 15.808 20. 882-0. 330 1.00 0.00 N ATOM 3338 C6 URI 15 16.964 21.133-1. 020 1.00 0.00 C ATOM 3339 C2 URI 15 15.832 20.393 0.964 1. 00 0.00 C ATOM 3340 02 URI 15 14.806 20.168 1.601 1. 00 0.00 O ATOM 3341 N3 URI 15 17.084 20.177 1.508 1. 00 0.00 N ATOM 3342 C4 URI 15 18.297 20.405 0.882 1.00 0.00 C ATOM 3343 04 URI 15 19.354 20.175 1.464 1.00 0.00 0 ATOM 3344 C5 URI 15 18.177 20.915-0. 464 1.00 0.00 C ATOM 3345 C2'URI 15 14.111 22.612-0. 833 1.00 0.00 C ATOM 3346 02'URI 15 12.690 22.795-0. 804 1.00 0.00 0 ATOM 3347 C3'URI 15 14.723 23.161-2. 105 1.00 0.00 C ATOM 3348 03'URI 15 14.024 24.350-2. 482 1.00 0.00 0 ATOM 3349 1H5'URI 15 15.122 21.246-4. 946 1.00 0.00 H ATOM 3350 2H5'URI 15 15. 204 23.017-4. 843 1.00 0.00 H ATOM 3351 H4'URI 15 13.367 22.183-3. 451 1.00 0.00 H ATOM 3352 H1'URI 15 13.729 20. 529-0.450 1.00 0.00 H ATOM 3353 H6 URI 15 16.906 21. 514-2. 039 1.00 0.00 H ATOM 3354 H3 URI 15 17.117 19.820 2.452 1.00 0. 00 H ATOM 3355 H5 URI 15 19.075 21.133-1. 040 1.00 0. 00 H

ATOM 3356 H2'URI 15 14.585 23.058 0.045 1.00 0.00 H ATOM 3357 H02'URI 15 12.310 22.180-1. 435 1.00 0.00 H ATOM 3358 H3'URI 15 15.801 23.316-2. 006 1.00 0.00 H ATOM 3359 P URI 16 14.423 25.772-1. 842 1.00 0.00 P ATOM 3360 01P URI 16 15.899 25.841-1. 747 1.00 0.00 0 ATOM 3361 02P URI 16 13.678 26.829-2. 562 1.00 0.00 O ATOM 3362 05'URI 16 13.826 25.661-0. 349 1.00 0.00 0 ATOM 3363 C5'URI 16 13.856 26.786 0.534 1.00 0.00 C ATOM 3364 C4'URI 16 12.452 27.195 0.964 1.00 0.00 C ATOM 3365 04'URI 16 11.586 27.352-0. 172 1.00 0.00 0 ATOM 3366 C1'URI 16 10.440 26.505-0. 024 1.00 0.00 C ATOM 3367 N1 URI 16 9.988 25.981-1. 332 1.00 0.00 N ATOM 3368 C6 URI 16 10.813 25.208-2. 107 1.00 0.00 C ATOM 3369 C2 URI 16 8.705 26.301-1. 742 1.00 0.00 C ATOM 3370 02 URI 16 7.951 26.994-1. 061 1.00 0.00 O ATOM 3371 N3 URI 16 8.315 25.795-2. 968 1.00 0.00 N ATOM 3372 C4 URI 16 9.083 25.010-3. 810 1.00 0.00 C ATOM 3373 04 URI 16 8.632 24.615-4. 883 1.00 0.00 O ATOM 3374 C5 URI 16 10.407 24.725-3. 305 1.00 0.00 C ATOM 3375 C2'URI 16 10.889 25.383 0.896 1.00 0.00 C ATOM 3376 02'URI 16 9.783 24. 787 1.583 1.00 0.00 0 ATOM 3377 C3'URI 16 11.811 26.124 1.847 1.00 0.00 C ATOM 3378 03'URI 16 11.015 26.780 2.840 1.00 0.00 0 ATOM 3379 1H5'URI 16 14.335 27.623 0.033 1.00 0.00 H ATOM 3380 2H5'URI 16 14.435 26.530 1.420 1.00 0.00 H ATOM 3381 H4'URI 16 12.500 28.136 1.510 1.00 0.00 H ATOM 3382 H1'URI 16 9.632 27.063 0.450 1.00 0.00 H ATOM 3383 H6 URI 16 11.816 24.975-1. 751 1.00 0.00 H ATOM 3384 H3 URI 16 7.381 26.020-3. 279 1.00 0.00 H ATOM 3385 H5 URI 16 11.088 24.114-3. 897 1.00 0.00 H ATOM 3386 H2'URI 16 11.456 24.635 0.334 1.00 0.00 H ATOM 3387 H02'URI 16 10.144 24.168 2.222 1.00 0.00 H ATOM 3388 H3'URI 16 12.555 25.463 2.292 1.00 0.00 H ATOM 3389 P CYT 17 11.721 27.546 4.068 1. 00 0.00 P ATOM 3390 01P CYT 17 10.705 27.767 5.123 1.00 0.00 0 ATOM 3391 02P CYT 17 12.483 28.693 3.526 1.00 0.00 0 ATOM 3392 05'CYT 17 12.772 26.447 4.600 1.00 0.00 O ATOM 3393 C5'CYT 17 12.314 25.290 5.303 1.00 0.00 C ATOM 3394 C4'CYT 17 13.468 24.413 5.772 1.00 0.00 C ATOM 3395 04'CYT 17 14.183 23.848 4.664 1.00 0.00 0 ATOM 3396 C1'CYT 17 15.577 24.107 4.830 1.00 0.00 C ATOM 3397 N1 CYT 17 16.267 24.197 3.528 1.00 0.00 N ATOM 3398 C6 CYT 17 15.585 24.546 2.404 1.00 0.00 C ATOM 3399 C2 CYT 17 17.625 23.906 3.492 1.00 0.00 C ATOM 3400 02 CYT 17 18.220 23.593 4.523 1.00 0.00 0 ATOM 3401 N3 CYT 17 18.267 23.976 2.294 1.00 0.00 N ATOM 3402 C4 CYT 17 17.607 24.318 1.180 1.00 0.00 C ATOM 3403 N4 CYT 17 18.263 24.376 0.022 1.00 0.00 N ATOM 3404 C5 CYT 17 16.210 24.620 1.218 1.00 0.00 C ATOM 3405 C2'CYT 17 15.632 25.418 5.587 1.00 0.00 C ATOM 3406 02'CYT 17 16.886 25.593 6.259 1.00 0.00 0 ATOM 3407 C3'CYT 17 14.485 25.232 6.568 1.00 0.00 C ATOM 3408 03'CYT 17 14.948 24.434 7.664 1.00 0.00 O ATOM 3409 1H5'CYT 17 11.672 24.708 4.650 1.00 0.00 H ATOM 3410 2H5'CYT 17 11.740 25.610 6.168 1.00 0.00 H ATOM 3411 H4'CYT 17 13.082 23.610 6.396 1.00 0.00 H ATOM 3412 H1'CYT 17 16.026 23.320 5.429 1.00 0.00 H ATOM 3413 H6 CYT 17 14.520 24.765 2.467 1.00 0.00 H ATOM 3414 1H4 CYT 17 17.774 24.632-0. 824 1.00 0.00 H ATOM 3415 2H4 CYT 17 19.251 24.165-0. 011 1.00 0.00 H

ATOM 3416 H5 CYT 17 15.669 24.902 0.320 1.00 0.00 H ATOM 3417 H2'CYT 17 15.421 26.254 4.914 1.00 0.00 H ATOM 3418 H02'CYT 17 17.566 25.655 5.584 1.00 0.00 H ATOM 3419 H3'CYT 17 14.066 26.183 6.896 1. 00 0. 00 H ATOM 3420 P GUA 18 14.433 24.716 9.164 1.00 0. 00 P ATOM 3421 01P GUA 18 14.492 26.174 9. 408 1.00 0.00 O ATOM 3422 02P GUA 18 15.136 23.787 10.077 1.00 0.00 O ATOM 3423 05'GUA 18 12.883 24.280 9.094 1.00 0.00 0 ATOM 3424 C5'GUA 18 12.517 22.908 8.917 1.00 0.00 C ATOM 3425 C4'GUA 18 11.025 22.761 8. 632 1.00 0.00 C ATOM 3426 04'GUA 18 10.641 23.480 7.461 1.00 0.00 0 ATOM 3427 C1'GUA 18 9.582 22.775 6.789 1.00 0.00 C ATOM 3428 N9 GUA 18 9.931 22.506 5.379 1.00 0.00 N ATOM 3429 C4 GUA 18 11.109 21.966 4.906 1.00 0.00 C ATOM 3430 N3 GUA 18 12.164 21.578 5.658 1.00 0.00 N ATOM 3431 C2 GUA 18 13.163 21.094 4.915 1. 00 0.00 C ATOM 3432 N2 GUA 18 14.283 20.669 5.500 1.00 0.00 N ATOM 3433 N1 GUA 18 13.119 21.002 3.538 1.00 0.00 N ATOM 3434 C6 GUA 18 12. 049 21.393 2.745 1.00 0.00 C ATOM 3435 06 GUA 18 12.108 21.268 1.524 1.00 0.00 O ATOM 3436 C5 GUA 18 10.982 21.910 3.526 1.00 0. 00 C ATOM 3437 N7 GUA 18 9.739 22.407 3.125 1.00 0.00 N ATOM 3438 C8 GUA 18 9.205 22.725 4.256 1.00 0.00 C ATOM 3439 C2'GUA 18 9.357 21. 474 7.566 1.00 0.00 C ATOM 3440 02'GUA 18 8.234 21.581 8.449 1.00 0.00 0 ATOM 3441 C3'GUA 18 10.658 21.320 8.336 1.00 0.00 C ATOM 3442 03'GUA 18 10.380 20.657 9.576 1.00 0.00 O ATOM 3443 1H5'GUA 18 12.763 22.354 9.823 1.00 0.00 H ATOM 3444 2H5'GUA 18 13. 081 22.493 8.082 1.00 0.00 H ATOM 3445 H4'GUA 18 10.448 23.121 9.483 1.00 0.00 H ATOM 3446 H1'GUA 18 8.673 23.376 6.827 1.00 0.00 H ATOM 3447 1H2 GUA 18 15.038 20.302 4.940 1.00 0.00 H ATOM 3448 2H2 GUA 18 14.375 20.713 6.505 1.00 0.00 H ATOM 3449 H1 GUA 18 13.917 20.623 3.047 1.00 0.00 H ATOM 3450 H8 GUA 18 8.204 23.155 4.305 1.00 0.00 H ATOM 3451 H2'GUA 18 9.228 20.639 6.871 1.00 0.00 H ATOM 3452 H02'GUA 18 8.232 20.797 9.003 1.00 0.00 H ATOM 3453 H3'GUA 18 11.423 20.811 7.748 1.00 0.00 H ATOM 3454 P GUA 19 10.384 19.049 9.669 1.00 0.00 P ATOM 3455 O1P GUA 19 11.651 18.554 9.083 1.00 0.00 0 ATOM 3456 02P GUA 19 10.010 18.665 11.049 1.00 0.00 0 ATOM 3457 05'GUA 19 9. 175 18.637 8.687 1.00 0.00 0 ATOM 3458 C5'GUA 19 9.292 17.506 7. 817 1.00 0.00 C ATOM 3459 C4'GUA 19 8.736 17.808 6.428 1.00 0. 00 C ATOM 3460 04'GUA 19 9.406 18.930 5.826 1.00 0.00 0 ATOM 3461 C1'GUA 19 9.853 18. 568 4. 509 1.00 0.00 C ATOM 3462 N9 GUA 19 11.297 18.260 4.501 1.00 0.00 N ATOM 3463 C4 GUA 19 12.085 18.030 3.395 1.00 0.00 C ATOM 3464 N3 GUA 19 11.674 18.062 2. 107 1.00 0.00 N ATOM 3465 C2 GUA 19 12.667 17.797 1.253 1.00 0.00 C ATOM 3466 N2 GUA 19 12.433 17.784-0. 059 1.00 0.00 N ATOM 3467 N1 GUA 19 13.962 17.523 1.646 1.00 0.00 N ATOM 3468 C6 GUA 19 14.407 17.484 2.960 1.00 0.00 C ATOM 3469 06 GUA 19 15.583 17.230 3.205 1.00 0.00 0 ATOM 3470 C5 GUA 19 13.358 17.765 3.874 1.00 0.00 C ATOM 3471 N7 GUA 19 13.382 17.825 5.270 1.00 0.00 N ATOM 3472 C8 GUA 19 12.155 18.115 5.541 1.00 0.00 C ATOM 3473 C2'GUA 19 9.034 17.345 4. 136 1.00 0.00 C ATOM 3474 02'GUA 19 7. 732 17. 706 3.657 1.00 0. 00 0 ATOM 3475 C3'GUA 19 8.968 16.641 5.475 1.00 0.00 C

ATOM 3476 03'GUA 19 7.818 15.791 5.494 1.00 0.00 0 ATOM 3477 1H5'GUA 19 8.743 16.668 8.246 1.00 0.00 H ATOM 3478 2H5'GUA 19 10.344 17. 233 7.727 1.00 0. 00 H ATOM 3479 H4'GUA 19 7.671 18.019 6.497 1. 00 0.00 H ATOM 3480 Hl'GUA 19 9.644 19.380 3.812 1.00 0.00 H ATOM 3481 1H2 GUA 19 11.505 17.975-0. 408 1.00 0.00 H ATOM 3482 2H2 GUA 19 13.184 17.584-0. 705 1.00 0. 00 H ATOM 3483 H1 GUA 19 14.657 17.335 0.939 1.00 0. 00 H ATOM 3484 H8 GUA 19 11.818 18.237 6.570 1.00 0.00 H ATOM 3485 H2'GUA 19 9.572 16.735 3.405 1.00 0.00 H ATOM 3486 H02'GUA 19 7.848 18.115 2.797 1.00 0.00 H ATOM 3487 H3'GUA 19 9.892 16.105 5.699 1.00 0.00 H ATOM 3488 P ADE 20 7.937 14.248 5.045 1.00 0.00 P ATOM 3489 01P ADE 20 6.609 13.614 5.207 1.00 0.00 O ATOM 3490 02P ADE 20 9.121 13.662 5.711 1.00 0.00 0 ATOM 3491 05'ADE 20 8.253 14.365 3.471 1.00 0.00 0 ATOM 3492 C5'ADE 20 7.248 14.809 2.555 1.00 0.00 C ATOM 3493 C4'ADE 20 7.801 14.944 1.139 1.00 0.00 C ATOM 3494 04'ADE 20 8.880 15.889 1.080 1.00 0. 00 0 ATOM 3495 C1'ADE 20 9.956 15.340 0.295 1.00 0.00 C ATOM 3496 N9 ADE 20 11.107 14.971 1.145 1.00 0.00 N ATOM 3497 C4 ADE 20 12.397 14.731 0.727 1.00 0.00 C ATOM 3498 N3 ADE 20 12.848 14.771-0. 543 1.00 0.00 N ATOM 3499 C2 ADE 20 14.146 14.490-0. 603 1.00 0.00 C ATOM 3500 N1 ADE 20 14.956 14.200 0.416 1.00 0.00 N ATOM 3501 C6 ADE 20 14.484 14.167 1.673 1.00 0.00 C ATOM 3502 N6 ADE 20 15.314 13.888 2.678 1.00 0.00 N ATOM 3503 C5 ADE 20 13.127 14.445 1.858 1.00 0.00 C ATOM 3504 N7 ADE 20 12.319 14.497 2.997 1.00 0.00 N ATOM 3505 C8 ADE 20 11.174 14.805 2.490 1.00 0.00 C ATOM 3506 C2'ADE 20 9.374 14.116-0. 396 1.00 0.00 C ATOM 3507 02'ADE 20 8.709 14.466-1. 617 1.00 0.00 O ATOM 3508 C3'ADE 20 8.401 13.633 0.657 1.00 0.00 C ATOM 3509 03'ADE 20 7.377 12.860 0. 026 1.00 0.00 0 ATOM 3510 1H5'ADE 20 6.869 15.778 2.882 1.00 0.00 H ATOM 3511 2H5'ADE 20 6.429 14.090 2.550 1.00 0.00 H ATOM 3512 H4'ADE 20 7.008 15.257 0.462 1.00 0.00 H ATOM 3513 H1'ADE 20 10.271 16.068-0. 453 1.00 0.00 H ATOM 3514 H2 ADE 20 14.599 14.500-1. 594 1.00 0.00 H ATOM 3515 1H6 ADE 20 14.969 13.870 3.627 1.00 0.00 H ATOM 3516 2H6 ADE 20 16.289 13.703 2.491 1.00 0.00 H ATOM 3517 H8 ADE 20 10.291 14.919 3.117 1.00 0.00 H ATOM 3518 H2'ADE 20 10.154 13.373-0. 569 1.00 0.00 H ATOM 3519 H02'ADE 20 9.384 14.562-2. 293 1.00 0.00 H ATOM 3520 H3'ADE 20 8.904 13.092 1.460 1.00 0.00 H ATOM 3521 P GUA 21 7. 585 11.282-0. 220 1.00 0.00 P ATOM 3522 O1P GUA 21 8.148 10.690 1.014 1.00 0.00 0 ATOM 3523 02P GUA 21 6.339 10. 734-0.800 1.00 0.00 0 ATOM 3524 05'GUA 21 8.725 11.256-1. 356 1.00 0.00 0 ATOM 3525 C5'GUA 21 8.434 11.697-2. 685 1.00 0.00 C ATOM 3526 C4'GUA 21 9.670 11.647-3. 577 1.00 0.00 C ATOM 3527 04'GUA 21 10.707 12.515-3. 097 1.00 0.00 0 ATOM 3528 Cl'GUA 21 11.975 11.837-3. 175 1.00 0. 00 C ATOM 3529 N9 GUA 21 12.499 11.532-1. 827 1. 00 0.00 N ATOM 3530 C4 GUA 21 13.818 11.324-1. 483 1.00 0.00 C ATOM 3531 N3 GUA 21 14.868 11. 308-2. 336 1.00 0.00 N ATOM 3532 C2 GUA 21 16. 026 11.082-1. 707 1.00 0. 00 C ATOM 3533 N2 GUA 21 17.160 11.011-2. 402 1.00 0.00 N ATOM 3534 N1 GUA 21 16.132 10.892-0. 344 1.00 0.00 N ATOM 3535 C6 GUA 21 15.072 10. 906 0.551 1.00 0.00 C

ATOM 3536 06 GUA 21 15.275 10.742 1.751 1.00 0.00 0 ATOM 3537 C5 GUA 21 13.836 11.140-0. 109 1.00 0.00 C ATOM 3538 N7 GUA 21 12.545 11.225 0.417 1.00 0. 00 N ATOM 3539 C8 GUA 21 11.844 11.449-0. 643 1.00 0.00 C ATOM 3540 C2'GUA 21 11.716 10.565-3. 973 1.00 0.00 C ATOM 3541 02'GUA 21 11.841 10.794-5. 382 1.00 0.00 0 ATOM 3542 C3'GUA 21 10.287 10.260-3. 579 1.00 0.00 C ATOM 3543 03'GUA 21 9.672 9.488-4. 615 1.00 0.00 0 ATOM 3544 1H5'GUA 21 8.063 12.722-2. 648 1.00 0.00 H ATOM 3545 2H5'GUA 21 7.662 11.055-3. 111 1.00 0.00 H ATOM 3546 H4'GUA 21 9.402 11.932-4. 593 1.00 0.00 H ATOM 3547 H1'GUA 21 12.690 12.462-3. 711 1.00 0.00 H ATOM 3548 1H2 GUA 21 17.144 11.128-3. 405 1.00 0.00 H ATOM 3549 2H2 GUA 21 18. 034 10.834-1. 928 1.00 0.00 H ATOM 3550 H1 GUA 21 17.046 10.731 0.056 1.00 0.00 H ATOM 3551 H8 GUA 21 10.761 11.550-0. 590 1.00 0.00 H ATOM 3552 H2'GUA 21 12.384 9.768-3. 642 1.00 0.00 H ATOM 3553 H02'GUA 21 12.777 10.771-5. 593 1.00 0.00 H ATOM 3554 H3'GUA 21 10.226 9.780-2. 601 1.00 0.00 H ATOM 3555 P ADE 22 9.750 7.879-4. 595 1.00 0.00 P ATOM 3556 O1P ADE 22 8.800 7.356-5. 603 1.00 0.00 0 ATOM 3557 02P ADE 22 9.656 7.426-3. 189 1.00 0.00 0 ATOM 3558 05'ADE 22 11.246 7.595-5. 117 1.00 0.00 0 ATOM 3559 C5'ADE 22 11.622 7.933-6. 455 1.00 0.00 C ATOM 3560 C4'ADE 22 13.138 7.997-6. 614 1.00 0.00 C ATOM 3561 04'ADE 22 13.725 8.928-5. 696 1.00 0.00 0 ATOM 3562 C1'ADE 22 14.940 8.370-5. 161 1.00 0.00 C ATOM 3563 N9 ADE 22 14.812 8.079-3. 719 1.00 0.00 N ATOM 3564 C4 ADE 22 15.839 7.987-2. 811 1.00 0.00 C ATOM 3565 N3 ADE 22 17.152 8.137-3. 075 1.00 0.00 N ATOM 3566 C2 ADE 22 17.885 7.987-1. 978 1.00 0.00 C ATOM 3567 N1 ADE 22 17.446 7.722-0. 746 1.00 0.00 N ATOM 3568 C6 ADE 22 16.130 7.576-0. 508 1.00 0.00 C ATOM 3569 N6 ADE 22 15.712 7.312 0.729 1.00 0.00 N ATOM 3570 C5 ADE 22 15.262 7.713-1. 593 1.00 0.00 C ATOM 3571 N7 ADE 22 13.872 7.626-1. 710 1.00 0. 00 N ATOM 3572 C8 ADE 22 13.703 7.850-2. 969 1.00 0.00 C ATOM 3573 C2'ADE 22 15.201 7.096-5. 953 1.00 0.00 C ATOM 3574 02'ADE 22 15.967 7.362-7. 134 1.00 0.00 0 ATOM 3575 C3'ADE 22 13.788 6.665-6. 285 1.00 0.00 C ATOM 3576 03'ADE 22 13.815 5.860-7. 468 1.00 0.00 0 ATOM 3577 1H5'ADE 22 11.197 8. 904-6.711 1.00 0.00 H ATOM 3578 2H5'ADE 22 11.225 7.180-7. 137 1.00 0.00 H ATOM 3579 H4'ADE 22 13.389 8.288-7. 633 1.00 0. 00 H ATOM 3580 H1'ADE 22 15.761 9.071-5. 319 1.00 0.00 H ATOM 3581 H2 ADE 22 18.964 8.087-2. 100 1.00 0.00 H ATOM 3582 1H6 ADE 22 14.726 7.200 0.916 1.00 0.00 H ATOM 3583 2H6 ADE 22 16.382 7.225 1.482 1.00 0.00 H ATOM 3584 H8 ADE 22 12.708 7.851-3. 413 1.00 0.00 H ATOM 3585 H2'ADE 22 15.692 6.349-5. 322 1.00 0.00 H ATOM 3586 H02'ADE 22 16.866 7.552-6. 855 1.00 0.00 H ATOM 3587 H3'ADE 22 13.304 6.166-5. 444 1.00 0.00 H ATOM 3588 P CYT 23 14.193 4.297-7. 385 1.00 0.00 P ATOM 3589 O1P CYT 23 13.450 3.698-6. 254 1.00 0.00 0 ATOM 3590 02P CYT 23 14.066 3.717-8. 740 1.00 0.00 0 ATOM 3591 05'CYT 23 15.755 4.335-6. 996 1.00 0.00 0 ATOM 3592 C5'CYT 23 16.725 4.817-7. 931 1.00 0.00 C ATOM 3593 C4'CYT 23 18.129 4.824-7. 334 1.00 0.00 C ATOM 3594 04'CYT 23 18. 210 5.640-6. 167 1.00 0.00 0 ATOM 3595 Cl'CYT 23 19.199 5.090-5. 273 1.00 0.00 C

ATOM 3596 N1 CYT 23 18.640 4.878-3. 919 1.00 0.00 N ATOM 3597 C6 CYT 23 17.335 4.515-3. 743 1.00 0.00 C ATOM 3598 C2 CYT 23 19.493 5.062-2. 837 1.00 0.00 C ATOM 3599 02 CYT 23 20.665 5.387-3. 019 1.00 0.00 0 ATOM 3600 N3 CYT 23 18.995 4.873-1. 585 1.00 0.00 N ATOM 3601 C4 CYT 23 17.719 4.519-1. 396 1.00 0.00 C ATOM 3602 N4 CYT 23 17.267 4.344-0. 155 1.00 0.00 N ATOM 3603 C5 CYT 23 16.837 4.326-2. 506 1.00 0.00 C ATOM 3604 C2'CYT 23 19.663 3.767-5. 896 1.00 0.00 C ATOM 3605 02'CYT 23 20. 909 3.924-6. 587 1.00 0.00 0 ATOM 3606 C3'CYT 23 18.528 3.446-6. 854 1.00 0.00 C ATOM 3607 03'CYT 23 19.047 2.715-7. 970 1.00 0.00 0 ATOM 3608 1H5'CYT 23 16.460 5.832-8. 228 1.00 0.00 H ATOM 3609 2H5'CYT 23 16.717 4.175-8. 813 1.00 0.00 H ATOM 3610 H4'CYT 23 18.844 5.178-8. 074 1.00 0.00 H ATOM 3611 H1'CYT 23 20.045 5.775-5. 211 1. 00 0.00 H ATOM 3612 H6 CYT 23 16.691 4.378-4. 611 1.00 0.00 H ATOM 3613 1H4 CYT 23 16.305 4.077 0.000 1.00 0.00 H ATOM 3614 2H4 CYT 23 17.887 4.477 0.631 1.00 0.00 H ATOM 3615 H5 CYT 23 15.799 4.034-2. 355 1.00 0.00 H ATOM 3616 H2'CYT 23 19.738 2.994-5. 126 1.00 0.00 H ATOM 3617 H02'CYT 23 21.575 4.137-5. 929 1.00 0.00 H ATOM 3618 H3'CYT 23 17.707 2.928-6. 357 1.00 0.00 H ATOM 3619 P GUA 24 19.154 1.109-7. 926 1.00 0.00 P ATOM 3620 01P GUA 24 18.119 0.598-6. 999 1.00 0.00 0 ATOM 3621 02P GUA 24 19.208 0.610-9. 318 1.00 0.00 0 ATOM 3622 05'GUA 24 20.595 0.878-7. 249 1.00 0.00 0 ATOM 3623 C5'GUA 24 21.791 1.259-7. 936 1.00 0.00 C ATOM 3624 C4'GUA 24 23.028 0.660-7. 277 1.00 0.00 C ATOM 3625 04'GUA 24 23.180 1.123-5. 925 1.00 0.00 0 ATOM 3626 Cl'GUA 24 23.404-0. 001-5.057 1.00 0.00 C ATOM 3627 N9 GUA 24 22.197-0. 324-4.275 1.00 0.00 N ATOM 3628 C4 GUA 24 22.131-1. 176-3.200 1.00 0.00 C ATOM 3629 N3 GUA 24 23.168-1. 865-2.676 1.00 0.00 N ATOM 3630 C2 GUA 24 22. 801-2.613-1. 636 1.00 0.00 C ATOM 3631 N2 GUA 24 23.706-3. 360-1.003 1.00 0.00 N ATOM 3632 N1 GUA 24 21.508-2. 674-1.155 1.00 0.00 N ATOM 3633 C6 GUA 24 20.426-1. 977-1.677 1.00 0.00 C ATOM 3634 06 GUA 24 19.312-2. 103-1.176 1.00 0.00 0 ATOM 3635 C5 GUA 24 20.809-1. 177-2.785 1.00 0.00 C ATOM 3636 N7 GUA 24 20.039-0. 331-3.588 1.00 0.00 N ATOM 3637 C8 GUA 24 20.922 0.116-4. 418 1.00 0.00 C ATOM 3638 C2'GUA 24 23.784-1. 152-5.974 1.00 0.00 C ATOM 3639 02'GUA 24 25.177-1. 122-6.309 1.00 0.00 0 ATOM 3640 C3'GUA 24 22.911-0. 855-7.174 1.00 0.00 C ATOM 3641 03'GUA 24 23.502-1. 444-8.335 1.00 0.00 0 ATOM 3642 1H5'GUA 24 21.875 2.346-7. 931 1.00 0.00 H ATOM 3643 2H5'GUA 24 21.734 0.911-8. 968 1.00 0. 00 H ATOM 3644 H4'GUA 24 23.915 0.922-7. 852 1.00 0.00 H ATOM 3645 H1'GUA 24 24.230 0.215-4. 379 1.00 0.00 H ATOM 3646 1H2 GUA 24 24.667-3. 357-1.313 1.00 0.00 H ATOM 3647 2H2 GUA 24 23.431-3. 927-0.215 1.00 0.00 H.

ATOM 3648 H1 GUA 24 21.312-3. 264-0.363 1.00 0.00 H ATOM 3649 H8 GUA 24 20.652 0.821-5. 204 1.00 0.00 H ATOM 3650 H2'GUA 24 23.504-2. 108-5.523 1. 00 0.00 H ATOM 3651 H02'GUA 24 25.361-0. 259-6.685 1.00 0. 00 H ATOM 3652 H3'GUA 24 21.880-1. 177-7.017 1.00 0.00 H ATOM 3653 P ADE 25 23.050-2. 910-8.824 1.00 0.00 P ATOM 3654 01P ADE 25 21.571-2. 947-8.873 1.00 0.00 O ATOM 3655 02P ADE 25 23.838-3. 261-10.027 1.00 0.00 0

ATOM 3656 05'ADE 25 23.538-3. 848-7.608 1.00 0.00 0 ATOM 3657 C5'ADE 25 24.932-3. 999-7. 326 1.00 0.00 C ATOM 3658 C4'ADE 25 25.168-4. 687-5.984 1.00 0.00 C ATOM 3659 04'ADE 25 24.555-3. 978-4.903 1.00 0.00 O ATOM 3660 C1'ADE 25 24.067-4. 926-3.931 1. 00 0.00 C ATOM 3661 N9 ADE 25 22.602-4. 827-3.770 1.00 0.00 N ATOM 3662 C4 ADE 25 21.843-5. 424-2.788 1.00 0.00 C ATOM 3663 N3 ADE 25 22.299-6. 210-1.793 1.00 0.00 N ATOM 3664 C2 ADE 25 21.307-6. 626-1.012 1.00 0.00 C ATOM 3665 N1 ADE 25 20.009-6. 344-1.138 1.00 0. 00 N ATOM 3666 C6 ADE 25 19. 578-5.558-2. 139 1.00 0.00 C ATOM 3667 N6 ADE 25 18.277-5. 288-2.245 1.00 0.00 N ATOM 3668 C5 ADE 25 20. 538-5.059-3. 027 1.00 0.00 C ATOM 3669 N7 ADE 25 20. 451-4. 234-4.152 1.00 0.00 N ATOM 3670 C8 ADE 25 21.688-4. 155-4.514 1. 00 0. 00 C ATOM 3671 C2'ADE 25 24. 467-6.308-4. 447 1.00 0. 00 C ATOM 3672 02'ADE 25 25.736-6. 718-3.921 1.00 0.00 O ATOM 3673 C3'ADE 25 24.533-6. 062-5.940 1.00 0.00 C ATOM 3674 03'ADE 25 25.433-7. 003-6.531 1.00 0. 00 0 ATOM 3675 1H5'ADE 25 25. 400-3. 015-7.307 1.00 0.00 H ATOM 3676 2H5'ADE 25 25.391-4. 596-8.115 1.00 0. 00 H ATOM 3677 H4'ADE 25 26.238-4. 771-5.798 1.00 0. 00 H ATOM 3678. H1'ADE 25 24.552-4. 744-2.972 1.00 0.00 H ATOM 3679 H2 ADE 25 21.585-7. 268-0.176 1.00 0.00 H ATOM 3680 1H6 ADE 25 17.943-4. 698-2.993 1.00 0. 00 H ATOM 3681 2H6 ADE 25 17.625-5. 673-1.576 1.00 0.00 H ATOM 3682 H8 ADE 25 21.987-3. 570-5.384 1.00 0. 00 H ATOM 3683 H2'ADE 25 23.689-7. 039-4.214 1.00 0. 00 H ATOM 3684 H02'ADE 25 25.596-6. 975-3.007 1.00 0.00 H ATOM 3685 H3'ADE 25 23. 543-6. 078-6.399 1.00 0.00 H ATOM 3686 P CYT 26 24.918-8. 468-6.951 1.00 0.00 P ATOM 3687 01P CYT 26 23.594-8. 329-7.597 1.00 0. 00 0 ATOM 3688 02P CYT 26 26.017-9. 161-7.661 1.00 0.00 0 ATOM 3689 05'CYT 26 24.708-9. 182-5.525 1.00 0.00 0 ATOM 3690 C5'CYT 26 25.832-9. 540-4.716 1.00 0. 00 C ATOM 3691 C4'CYT 26 25.393-10. 208-3.417 1.00 0.00 C ATOM 3692 04'CYT 26 24.634-9. 316-2.587 1.00 0.00 0 ATOM 3693 C1'CYT 26 23.484-10. 012-2.066 1.00 0. 00 C ATOM 3694 N1 CYT 26 22.234-9. 531-2.695 1.00 0. 00 N ATOM 3695 C6 CYT 26 22.221-9. 104-3.991 1.00 0.00 C ATOM 3696 C2 CYT 26 21.077-9. 545-1.926 1.00 0.00 C ATOM 3697 02 CYT 26 21.112-9. 933-0.760 1.00 0.00 0 ATOM 3698 N3 CYT 26 19.917-9. 121-2.499 1.00 0.00 N ATOM 3699 C4 CYT 26 19.893-8. 702-3.771 1.00 0.00 C ATOM 3700 N4 CYT 26 18.742-8. 288-4.300 1.00 0.00 N ATOM 3701 C5 CYT 26 21.082-8. 687-4. 564 1.00 0. 00 C ATOM 3702 C2'CYT 26 23.718-11. 483-2.381 1.00 0.00 C ATOM 3703 02'CYT 26 24.509-12. 121-1.371 1.00 0.00 0 ATOM 3704 C3'CYT 26 24.461-11. 374-3.694 1.00 0.00 C ATOM 3705 03'CYT 26 25.244-12. 554-3.891 1.00 0.00 0 ATOM 3706 1H5'CYT 26 26.404-8. 642-4.479 1.00 0.00 H ATOM 3707 2H5'CYT 26 26.466-10. 229-5.274 1. 00 0.00 H ATOM 3708 H4'CYT 26 26. 267-10.558-2. 869 1.00 0.00 H ATOM 3709 H1'CYT 26 23.429-9. 873-0.987 1.00 0.00 H ATOM 3710 H6 CYT 26 23.148-9. 091-4.566 1.00 0.00 H ATOM 3711 1H4 CYT 26 18.713-7. 967-5.258 1.00 0. 00 H ATOM 3712 2H4 CYT 26 17.899-8. 296-3.745 1. 00 0.00 H ATOM 3713 H5 CYT 26 21.065-8. 365-5.601 1.00 0.00 H ATOM 3714 H2'CYT 26 22. 764-11. 997-2.522 1.00 0.00 H ATOM 3715 H02'CYT 26 24.002-12. 100-0. 556 1.00 0. 00 H

ATOM 3716 H3'CYT 26 23.785-11. 170-4.529 1.00 0.00 H ATOM 3717 P CYT 27 24.817-13. 637-5.002 1.00 0.00 P ATOM 3718 01P CYT 27 25.843-14. 703-5.030 1.00 0.00 0 ATOM 3719 02P CYT 27 24.470-12. 914-6.247 1.00 0.00 0 ATOM 3720 05'CYT 27 23.465-14. 252-4.382 1.00 0.00 0 ATOM 3721 C5'CYT 27 23.507-15. 005-3.168 1.00 0.00 C ATOM 3722 C4'CYT 27 22.111-15. 243-2.600 1.00 0.00 C ATOM 3723 04'CYT 27 21.423-14. 023-2.336 1.00 0.00 0 ATOM 3724 Cl'CYT 27 20.005-14. 265-2.434 1.00 0.00 C ATOM 3725 N1 CYT 27 19.332-13. 266-3.297 1.00 0.00 N ATOM 3726 C6 CYT 27 20.016-12. 573-4.256 1.00 0.00 C ATOM 3727 C2 CYT 27 17.971-13. 073-3.097 1.00 0.00 C ATOM 3728 02 CYT 27 17.378-13. 715-2.234 1.00 0.00 0 ATOM 3729 N3 CYT 27 17.324-12. 169-3.881 1.00 0.00 N ATOM 3730 C4 CYT 27 17.979-11. 482-4.825 1.00 0.00 C ATOM 3731 N4 CYT 27 17.313-10. 602-5.571 1.00 0.00 N ATOM 3732 C5 CYT 27 19.380-11. 677-5.039 1.00 0.00 C ATOM 3733 C2'CYT 27 19.843-15. 680-3. 007 1.00 0.00 C ATOM 3734 02'CYT 27 19.514-16. 624-1.980 1.00 0.00 0 ATOM 3735 C3'CYT 27 21.216-15. 951-3.594 1.00 0.00 C ATOM 3736 03'CYT 27 21.476-17. 356-3.534 1.00 0.00 0 ATOM 3737 1H5'CYT 27 24.101-14. 463-2.432 1.00 0.00 H ATOM 3738 2H5'CYT 27 23.978-15. 968-3.364 1.00 0.00 H ATOM 3739 H4'CYT 27 22.178-15. 826-1.683 1.00 0.00 H ATOM 3740 H1'CYT 27 19.568-14. 232-1.436 1.00 0.00 H ATOM 3741 H6 CYT 27 21.087-12. 739-4.384 1.00 0.00 H ATOM 3742 1H4 CYT 27 17.797-10. 076-6.285 1.00 0.00 H ATOM 3743 2H4 CYT 27 16.324-10. 458-5.421 1.00 0.00 H ATOM 3744 H5 CYT 27 19.911-11. 126-5.816 1.00 0.00 H ATOM 3745 H2'CYT 27 19.088-15. 682-3.796 1.00 0.00 H ATOM 3746 H02'CYT 27 20.219-16. 596-1.330 1.00 0.00 H ATOM 3747 H3'CYT 27 21.318-15. 544-4.602 1.00 0.00 H ATOM 3748 P GUA 28 21.033-18. 318-4.748 1.00 0.00 P ATOM 3749 O1P GUA 28 21.472-19. 695-4.431 1.00 0.00 0 ATOM 3750 02P GUA 28 21.454-17. 684-6. 018 1.00 0.00 0 ATOM 3751 05'GUA 28 19.425-18. 267-4.669 1.00 0.00 O ATOM 3752 C5'GUA 28 18.711-19. 144-3.793 1.00 0.00 C ATOM 3753 C4'GUA 28 17.200-18. 966-3.923 1. 00 0.00 C ATOM 3754 04'GUA 28 16.781-17. 655-3.551 1.00 0.00 0 ATOM 3755 Cl'GUA 28 15.592-17. 318-4.291 1.00 0.00 C ATOM 3756 N9 GUA 28 15.726-16. 008-4. 960 1.00 0.00 N ATOM 3757 C4 GUA 28 14.704-15. 136-5.263 1.00 0.00 C ATOM 3758 N3 GUA 28 13.392-15. 334-5.004 1.00 0.00 N ATOM 3759 C2 GUA 28 12. 636-14.313-5. 415 1.00 0.00 C ATOM 3760 N2 GUA 28 11.316-14. 351-5.243 1.00 0.00 N ATOM 3761 N1 GUA 28 13.141-13. 186-6.032 1.00 0.00 N ATOM 3762 C6 GUA 28 14.483-12. 959-6.309 1.00 0.00 C ATOM 3763 06 GUA 28 14.831-11. 919-6.864 1.00 0.00 0 ATOM 3764 C5 GUA 28 15.295-14. 042-5.876 1.00 0.00 C ATOM 3765 N7 GUA 28 16.679-14. 216-5.964 1.00 0.00 N ATOM 3766 C8 GUA 28 16.835-15. 373-5.413 1.00 0.00 C ATOM 3767 C2'GUA 28 15.381-18. 437-5.316 1.00 0.00 C ATOM 3768 02'GUA 28 14.363-19. 351-4.889 1. 00 0.00 0 ATOM 3769 C3'GUA 28 16.746-19. 101-5.361 1.00 0. 00 C ATOM 3770 03'GUA 28 16.577-20. 490-5.663 1.00 0.00 0 ATOM 3771 1H5'GUA 28 19.005-18. 938-2.764 1.00 0.00 H ATOM 3772 2H5'GUA 28 18.968-20. 175-4.037 1.00 0.00 H ATOM 3773 H4'GUA 28 16.686-19. 699-3.303 1.00 0.00 H ATOM 3774 Hl'GUA 28 14.741-17. 290-3.610 1.00 0.00 H

ATOM 3775 1H2 GUA 28 10.888-15. 152-4.802 1.00 0.00 H ATOM 3776 2H2 GUA 28 10.744-13. 578-5.552 1.00 0.00 H ATOM 3777 Hl GUA 28 12.502-12. 455-6.310 1.00 0.00 H ATOM 3778 H8 GUA 28 17.821-15. 826-5.323 1.00 0.00 H ATOM 3779 H2'GUA 28 15.139-18. 011-6.291 1.00 0.00 H ATOM 3780 H02'GUA 28 14.232-19. 983-5.599 1.00 0.00 H ATOM 3781 H3'GUA 28 17.422-18. 598-6.054 1.00 0.00 H ATOM 3782 P CYT 29 16.412-20. 981-7.189 1.00 0.00 P ATOM 3783 01P CYT 29 17.247-20. 112-8.048 1.00 0.00 0 ATOM 3784 02P CYT 29 16.594-22. 449-7.226 1.00 0.00 0 ATOM 3785 05'CYT 29 14.865-20. 654-7.498 1.00 0.00 0 ATOM 3786 C5'CYT 29 13.832-21. 565-7.106 1.00 0.00 C ATOM 3787 C4'CYT 29 12.446-21. 029-7.456 1.00 0.00 C ATOM 3788 04'CYT 29 12.184-19. 777-6.808 1.00 0.00 0 ATOM 3789 C1'CYT 29 11.532-18. 882-7.731 1.00 0.00 C ATOM 3790 N1 CYT 29 12.405-17. 734-8.073 1.00 0.00 N ATOM 3791 C6 CYT 29 13.748-17. 901-8.253 1.00 0.00 C ATOM 3792 C2 CYT 29 11.810-16. 482-8.188 1.00 0.00 C ATOM 3793 02 CYT 29 10.597-16. 354-8.029 1.00 0.00 0 ATOM 3794 N3 CYT 29 12.604-15. 416-8.484 1.00 0.00 N ATOM 3795 C4 CYT 29 13.923-15. 568-8.662 1.00 0.00 C ATOM 3796 N4 CYT 29 14.671-14. 503-8.946 1.00 0.00 N ATOM 3797 C5 CYT 29 14.538-16. 852-8.547 1.00 0.00 C ATOM 3798 C2'CYT 29 11.205-19. 718-8. 964 1.00 0.00 C ATOM 3799 02'CYT 29 9.921-20. 343-8.848 1.00 0.00 0 ATOM 3800 C3'CYT 29 12.326-20. 736-8.942 1.00 0.00 C ATOM 3801 03'CYT 29 11.888-21. 924-9.610 1.00 0.00 0 ATOM 3802 1H5'CYT 29 13.889-21. 727-6.029 1.00 0.00 H ATOM 3803 2H5'CYT 29 13.985-22. 516-7.617 1.00 0.00 H ATOM 3804 H4'CYT 29 11.687-21. 753-7.162 1.00 0.00 H ATOM 3805 H1'CYT 29 10.606-18. 516-7.286 1.00 0.00 H ATOM 3806 H6 CYT 29 14.186-18. 894-8.156 1.00 0.00 H ATOM 3807 1H4 CYT 29 15.667-14. 606-9.079 1.00 0.00 H ATOM 3808 2H4 CYT 29 14.242-13. 593-9.032 1.00 0.00 H ATOM 3809 H5 CYT 29 15.611-16. 978-8.693 1.00 0.00 H ATOM 3810 H2'CYT 29 11.264-19. 104-9.865 1.00 0.00 H ATOM 3811 H02'CYT 29 9.836-20. 958-9.580 1.00 0.00 H ATOM 3812 H3'CYT 29 13.251-20. 335-9.359 1.00 0.00 H ATOM 3813 P CYT 30 12.303-22. 200-11.142 1.00 0.00 P ATOM 3814 01P CYT 30 13.701-21. 753-11.332 1.00 0. 00 0 ATOM 3815 02P CYT 30 11.920-23. 589-11.483 1.00 0.00 0 ATOM 3816 05'CYT 30 11.340-21. 195-11.953 1.00 0.00 0 ATOM 3817 C5'CYT 30 9.934-21. 450-12.048 1.00 0.00 C ATOM 3818 C4'CYT 30 9.152-20. 175-12.353 1.00 0.00 C ATOM 3819 04'CYT 30 9.412-19. 153-11.385 1.00 0.00 0 ATOM 3820 C1'CYT 30 9.474-17. 877-12.046 1.00 0.00 C ATOM 3821 N1 CYT 30 10.823-17. 275-11.938 1.00 0.00 N ATOM 3822 C6 CYT 30 11.948-18. 049-11.980 1.00 0.00 C ATOM 3823 C2 CYT 30 10.900-15. 895-11.803 1.00 0.00 C ATOM 3824 02 CYT 30 9.874-15. 216-11.767 1.00 0.00 0 ATOM 3825 N3 CYT 30 12.131-15. 323-11.716 1.00 0.00 N ATOM 3826 C4 CYT 30 13.242-16. 068-11.758 1.00 0.00 C ATOM 3827 N4 CYT 30 14.431-15. 473-11.678 1.00 0.00 N ATOM 3828 C5 CYT 30 13.170-17. 490-11.894 1.00 0.00 C ATOM 3829 C2'CYT 30 9.103-18. 141-13.504 1.00 0.00 C ATOM 3830 02'CYT 30 7.691-18. 019-13.714 1. 00 0.00 O ATOM 3831 C3'CYT 30 9.570-19. 571-13.682 1.00 0.00 C ATOM 3832 03'CYT 30 8.924-20. 211-14.788 1.00 0.00 O ATOM 3833 1H5'CYT 30 9.582-21. 865-11.104 1.00 0.00 H

ATOM 3834 2H5'CYT 30 9.758-22. 174-12.843 1.00 0.00 H ATOM 3835 H4'CYT 30 8.085-20. 393-12.368 1.00 0.00 H ATOM 3836 H1'CYT 30 8.739-17. 204-11.602 1.00 0.00 H ATOM 3837 H6 CYT 30 11.857-19. 130-12. 082 1.00 0.00 H ATOM 3838 1H4 CYT 30 15.276-16. 025-11.711 1.00 0.00 H ATOM 3839 2H4 CYT 30 14.488-14. 468-11.593 1.00 0.00 H ATOM 3840 H5 CYT 30 14.073-18. 100-11.926 1.00 0.00 H ATOM 3841 H2'CYT 30 9.660-17. 472-14. 165 1.00 0.00 H ATOM 3842 H02'CYT 30 7.465-17. 093-13.598 1.00 0.00 H ATOM 3843 H3'CYT 30 10.658-19. 600-13.787 1.00 0.00 H ATOM 3844 H03'CYT 30 7.982-20. 045-14.703 1.00 0.00 H TER ATOM 3845 05'GUA 1 23.943-1. 222-1.905 1.00 0.00 O ATOM 3846 C5'GUA 1 24.844-1. 478-0.824 1.00 0.00 C ATOM 3847 C4'GUA 1 25.682-0. 247-0. 487 1.00 0.00 C ATOM 3848 04'GUA 1 26.411 0.219-1. 633 1.00 0.00 O ATOM 3849 C1'GUA 1 26.258 1.643-1. 760 1.00 0.00 C ATOM 3850 N9 GUA 1 25.385 1.987-2. 902 1.00 0.00 N ATOM 3851 C4 GUA 1 25.609 2.971-3. 840 1.00 0.00 C ATOM 3852 N3 GUA 1 26.663 3.817-3. 863 1.00 0.00 N ATOM 3853 C2 GUA 1 26. 610 4.662-4. 897 1.00 0.00 C ATOM 3854 N2 GUA 1 27.572 5.569-5. 066 1.00 0.00 N ATOM 3855 N1 GUA 1 25.593 4.666-5. 832 1.00 0.00 N ATOM 3856 C6 GUA 1 24.501 3.809-5. 829 1.00 0.00 C ATOM 3857 06. GUA 1 23.649 3. 892-6. 712 1.00 0.00 O ATOM 3858 C5 GUA 1 24. 550 2.907-4. 732 1.00 0.00 C ATOM 3859 N7 GUA 1 23.658 1.895-4. 366 1.00 0.00 N ATOM 3860 C8 GUA 1 24.219 1.421-3. 304 1.00 0.00 C ATOM 3861 C2'GUA 1 25.659 2. 113-0. 442 1.00 0.00 C ATOM 3862 02'GUA 1 26.675 2.364 0.536 1.00 0.00 0 ATOM 3863 C3'GUA 1 24.802 0.921-0. 066 1.00 0.00 C ATOM 3864 03'GUA 1 24.655 0.890 1.359 1.00 0. 00 O ATOM 3865 H5'GUA 1 24.475-1. 086-2.693 1.00 0.00 H ATOM 3866 1H5'GUA 1 25.509-2. 296-1.102 1.00 0.00 H ATOM 3867 2H5'GUA 1 24.270-1. 770 0.055 1.00 0.00 H ATOM 3868 H4'GUA 1 26.382-0. 486 0.312 1.00 0.00 H ATOM 3869 H1'GUA 1 27.237 2.103-1. 898 1.00 0.00 H ATOM 3870 1H2 GUA 1 28.340 5.617-4. 413 1.00 0.00 H ATOM 3871 2H2 GUA 1 27.535 6.204-5. 850 1.00 0.00 H ATOM 3872 H1 GUA 1 25.629 5.333-6. 588 1.00 0.00 H ATOM 3873 H8 GUA 1 23.771 0.596-2. 750 1.00 0.00 H ATOM 3874 H2'GUA 1 25.037 2.996-0. 601 1.00 0.00 H ATOM 3875 H02'GUA 1 26.233 2.517 1. 374 1.00 0.00 H ATOM 3876 H3'GUA 1 23.844 0.925-0. 588 1.00 0.00 H ATOM 3877 P GUA 2 23.400 1.609 2.070 1.00 0.00 P ATOM 3878 O1P GUA 2 22.190 1.337 1.261 1.00 0.00 0 ATOM 3879 02P GUA 2 23.420 1.258 3.508 1. 00 0.00 O ATOM 3880 05'GUA 2 23.762 3.171 1.924 1. 00 0.00 O ATOM 3881 C5'GUA 2 24.711 3.786 2.801 1. 00 0. 00 C ATOM 3882 C4'GUA 2 25.097 5. 183 2.323 1.00 0.00 C ATOM 3883 04'GUA 2 25.638 5.156 0.996 1.00 0.00 0 ATOM 3884 C1'GUA 2 25.131 6.277 0.247 1.00 0.00 C ATOM 3885 N9 GUA 2 24. 253 5.831-0. 856 1. 00 0.00 N ATOM 3886 C4 GUA 2 24.149 6.403-2. 104 1.00 0.00 C ATOM 3887 N3 GUA 2 24.834 7.484-2. 542 1.00 0.00 N ATOM 3888 C2 GUA 2 24.519 7.806-3. 800 1.00 0.00 C ATOM 3889 N2 GUA 2 25.103 8.852-4. 386 1.00 0.00 N ATOM 3890 N1 GUA 2 23.600 7.112-4. 562 1.00 0.00 N ATOM 3891 C6 GUA 2 22.885 6.001-4. 136 1.00 0.00 C

ATOM 3892 06 GUA 2 22. 086 5.455-4. 892 1.00 0.00 0 ATOM 3893 C5 GUA 2 23.213 5.651-2. 799 1.00 0.00 C ATOM 3894 N7 GUA 2 22.727 4.611-2. 001 1.00 0.00 N ATOM 3895 C8 GUA 2 23.380 4.794-0. 903 1.00 0.00 C ATOM 3896 C2'GUA 2 24.364 7. 138 1.246 1.00 0.00 C ATOM 3897 02'GUA 2 25.219 8.103 1.871 1.00 0.00 0 ATOM 3898 C3'GUA 2 23.884 6.093 2.231 1.00 0.00 C ATOM 3899 03'GUA 2 23.679 6.715 3.504 1.00 0.00 0 ATOM 3900 1H5'GUA 2 25.606 3.166 2.849 1.00 0.00 H ATOM 3901 2H5'GUA 2 24.276 3.860 3.799 1.00 0.00 H ATOM 3902 H4'GUA 2 25.830 5.615 3.003 1.00 0.00 H ATOM 3903 H1'GUA 2 25.965 6.849-0. 161 1.00 0.00 H ATOM 3904 1H2 GUA 2 25.783 9.400-3. 878 1.00 0.00 H ATOM 3905 2H2 GUA 2 24.865 9.097-5. 337 1.00 0.00 H ATOM 3906 H1 GUA 2 23.419 7. 420-5. 507 1.00 0.00 H ATOM 3907 H8 GUA 2 23.234 4.139-0. 044 1.00 0.00 H ATOM 3908 H2'GUA 2 23.515 7.622 0.756 1.00 0. 00 H ATOM 3909 H02'GUA 2 24. 723 8.498 2.592 1.00 0.00 H ATOM 3910 H3'GUA 2 23.000 5.565 1.870 1.00 0.00 H ATOM 3911 P CYT 3 22.206 7.185 3.956 1.00 0.00 P ATOM 3912 01P CYT 3 22.278 7.650 5.360 1.00 0.00 O ATOM 3913 02P CYT 3 21.244 6.125 3.579 1.00 0.00 O ATOM 3914 05'CYT 3 21.941 8.463 3.012 1.00 0.00 0 ATOM 3915 C5'CYT 3 22.518 9.733 3.328 1.00 0.00 C ATOM 3916 C4'CYT 3 22.371 10.723 2.175 1.00 0.00 C ATOM 3917 04'CYT 3 23.008 10.249 0.981 1.00 0.00 0 ATOM 3918 Cl'CYT 3 22.168 10.538-0. 156 1.00 0. 00 C ATOM 3919 N1 CYT 3 21.614 9.298-0. 747 1.00 0.00 N ATOM 3920 C6 CYT 3 21.235 8.251 0.043 1.00 0.00 C ATOM 3921 C2 CYT 3 21.479 9.248-2. 128 1.00 0.00 C ATOM 3922 02 CYT 3 21.828 10.202-2. 819 1.00 0.00 O ATOM 3923 N3 CYT 3 20.953 8.123-2. 684 1.00 0.00 N ATOM 3924 C4 CYT 3 20.575 7.089-1. 921 1.00 0.00 C ATOM 3925 N4 CYT 3 20.062 6.003-2. 498 1.00 0.00 N ATOM 3926 C5 CYT 3 20.713 7.137-0. 498 1.00 0.00 C ATOM 3927 C2'CYT 3 21.053 11.434 0.372 1.00 0.00 C ATOM 3928 02'CYT 3 21.432 12.815 0.352 1.00 0.00 0 ATOM 3929 C3'CYT 3 20.914 10.911 1.786 1.00 0.00 C ATOM 3930 03'CYT 3 20.342 11.934 2.605 1.00 0.00 0 ATOM 3931 1H5'CYT 3 23.577 9.600 3.548 1.00 0.00 H ATOM 3932 2H5'CYT 3 22.021 10.139 4.210 1.00 0.00 H ATOM 3933 H4'CYT 3 22. 802 11.683 2.457 1.00 0.00 H ATOM 3934 H1'CYT 3 22.745 11. 077-0. 908 1.00 0.00 H ATOM 3935 H6 CYT 3 21.359 8.317 1.124 1.00 0.00 H ATOM 3936 1H4 CYT 3 19.774 5.218-1. 932 1.00 0.00 H ATOM 3937 2H4 CYT 3 19.956 5.968-3. 502 1.00 0.00 H ATOM 3938 H5 CYT 3 20. 402 6.302 0.128 1.00 0.00 H ATOM 3939 H2'CYT 3 20.132 11.267-0. 191 1.00 0.00 H ATOM 3940 H02'CYT 3 22.252 12.894 0. 846 1.00 0.00 H ATOM 3941 H3'CYT 3 20.353 9.974 1.822 1. 00 0. 00 R ATOM 3942 P GUA 4 18.808 11.830 3.084 1.00 0.00 P ATOM 3943 01P GUA 4 18.531 12.961 3.998 1.00 0.00 0 ATOM 3944 02P GUA 4 18.557 10.442 3.532 1.00 0. 00 O ATOM 3945 05'GUA 4 17.993 12.071 1.715 1.00 0.00 O ATOM 3946 C5'GUA 4 17.727 13.399 1. 253 1.00 0.00 C ATOM 3947 C4'GUA 4 17.031 13.399-0. 107 1. 00 0.00 C ATOM 3948 04'GUA 4 17.810 12. 744-1. 108 1.00 0.00 0 ATOM 3949 C1'GUA 4 16.923 12.128-2. 064 1.00 0.00 C ATOM 3950 N9 GUA 4 17.185 10.681-2. 197 1.00 0.00 N ATOM 3951 C4 GUA 4 16.678 9.848-3. 167 1.00 0. 00 C

ATOM 3952 N3 GUA 4 15.844 10.215-4. 165 1. 00 0.00 N ATOM 3953 C2 GUA 4 15.519 9.189-4. 955 1.00 0.00 C ATOM 3954 N2 GUA 4 14.692 9.381-5. 982 1.00 0.00 N ATOM 3955 N1 GUA 4 15.986 7.902-4. 771 1.00 0.00 N ATOM 3956 C6 GUA 4 16.842 7.501-3. 753 1.00 0.00 C ATOM 3957 06 GUA 4 17.199 6.328-3. 674 1.00 0.00 0 ATOM 3958 C5 GUA 4 17.191 8.588-2. 907 1.00 0.00 C ATOM 3959 N7 GUA 4 18.017 8.618-1. 779 1.00 0.00 N ATOM 3960 C8 GUA 4 17.953 9.861-1. 438 1. 00 0.00 C ATOM 3961 C2'GUA 4 15.501 12.378-1. 556 1.00 0.00 C ATOM 3962 02'GUA 4 14.919 13.527-2. 182 1.00 0.00 O ATOM 3963 C3'GUA 4 15.737 12.611-0. 077 1.00 0.00 C ATOM 3964 03'GUA 4 14.690 13.446 0.429 1.00 0.00 0 ATOM 3965 1H5'GUA 4 18.668 13.942 1.169 1.00 0.00 H ATOM 3966 2H5'GUA 4 17.088 13.904 1.978 1.00 0.00 H ATOM 3967 H4'GUA 4 16.831 14.423-0. 419 1.00 0.00 H ATOM 3968 H1'GUA 4 17.048 12.610-3. 034 1.00 0.00 H ATOM 3969 1H2 GUA 4 14.314 10.301-6. 160 1.00 0.00 H ATOM 3970 2H2 GUA 4 14.443 8.610-6. 581 1.00 0.00 H ATOM 3971 H1 GUA 4 15.700 7.180-5. 418 1.00 0.00 H ATOM 3972 H8 GUA 4 18. 491 10.236-0. 569 1.00 0.00 H ATOM 3973 H2'GUA 4 14.882 11.491-1. 709 1.00 0.00 H ATOM 3974 H02'GUA 4 14.305 13.913-1. 554 1.00 0.00 H ATOM 3975 H3'GUA 4 15.837 11.674 0.474 1. 00 0.00 H ATOM 3976 P CYT 5 13.274 12.806 0.859 1.00 0.00 P ATOM 3977 O1P CYT 5 13.539 11.579 1.642 1.00 0.00 0 ATOM 3978 02P CYT 5 12.437 13.882 1.435 1.00 0.00 0 ATOM 3979 05'CYT 5 12.638 12.371-0. 557 1.00 0.00 0 ATOM 3980 C5'CYT 5 11.940 13.321-1. 369 1.00 0.00 C ATOM 3981 C4'CYT 5 11.229 12.647-2. 540 1.00 0.00 C ATOM 3982 04'CYT 5 12.148 11.967-3. 404 1.00 0.00 0 ATOM 3983 Cl'CYT 5 11.575 10.710-3. 821 1.00 0.00 C ATOM 3984 N1 CYT 5 12.334 9.563-3. 273 1.00 0.00 N ATOM 3985 C6 CYT 5 12.939 9. 643-2. 052 1. 00 0.00 C ATOM 3986 C2 CYT 5 12.400 8.405-4. 040 1.00 0.00 C ATOM 3987 02 CYT 5 11.847 8.355-5. 137 1.00 0.00 0 ATOM 3988 N3 CYT 5 13.087 7.340-3. 542 1. 00 0.00 N ATOM 3989 C4 CYT 5 13.684 7.406-2. 345 1.00 0.00 C ATOM 3990 N4 CYT 5 14.346 6.345-1. 884 1.00 0.00 N ATOM 3991 C5 CYT 5 13.619 8.595-1. 554 1. 00 0.00 C ATOM 3992 C2'CYT 5 10.141 10.712-3. 301 1.00 0.00 C ATOM 3993 02'CYT 5 9.238 11.296-4. 248 1.00 0.00 0 ATOM 3994 C3'CYT 5 10.280 11.565-2. 058 1.00 0.00 C ATOM 3995 03'CYT 5 9.015 12.163-1. 758 1.00 0.00 O ATOM 3996 1H5'CYT 5 12. 650 14.050-1. 758 1.00 0.00 H ATOM 3997 2H5'CYT 5 11.201 13.837-0. 756 1.00 0.00 H ATOM 3998 H4'CYT 5 10.677 13.390-3. 114 1.00 0.00 H ATOM 3999 H1'CYT 5 11.567 10.657-4. 910 1.00 0.00 H ATOM 4000 H6 CYT 5 12.872 10.565-1. 475 1.00 0.00 H ATOM 4001 1H4 CYT 5 14.397 5.502-2. 437 1.00 0.00 H ATOM 4002 2H4 CYT 5 14.797 6.385-0. 981 1.00 0.00 H ATOM 4003 H5 CYT 5 14.100 8.650-0. 578 1. 00 0.00 H ATOM 4004 H2'CYT 5 9.834 9.698-3. 037 1.00 0.00 H ATOM 4005 H02'CYT 5 8.386 11.383-3. 813 1. 00 0.00 H ATOM 4006 H3'CYT 5 10.690 11.001-1. 219 1.00 0. 00 H ATOM 4007 P URI 6 8. 083 11.555-0. 593 1.00 0.00 P ATOM 4008 O1P URI 6 8.959 11.059 0.492 1.00 0.00 0 ATOM 4009 02P URI 6 7.019 12. 538-0. 291 1. 00 0. 00 0 ATOM 4010 05'URI 6 7.408 10.285-1. 316 1.00 0.00 O ATOM 4011 C5'URI 6 6.399 10.468-2. 313 1.00 0.00 C

ATOM 4012 C4'URI 6 6.226 9.222-3. 177 1.00 0.00 C ATOM 4013 04'URI 6 7.452 8.847-3. 821 1.00 0.00 0 ATOM 4014 C1'URI 6 7.594 7.413-3. 778 1.00 0.00 C ATOM 4015 N1 URI 6 8.712 7.002-2. 896 1. 00 0.00 N ATOM 4016 C6 URI 6 9.034 7.723-1. 775 1.00 0.00 C ATOM 4017 C2 URI 6 9.411 5.859-3. 243 1.00 0.00 C ATOM 4018 02 URI 6 9.138 5.199-4. 244 1.00 0.00 0 ATOM 4019 N3 URI 6 10.440 5.496-2. 396 1.00 0.00 N ATOM 4020 C4 URI 6 10.828 6.163-1. 248 1.00 0.00 C ATOM 4021 04 URI 6 11. 760 5.745-0. 566 1. 00 0.00 0 ATOM 4022 C5 URI 6 10.047 7. 343-0.960 1.00 0.00 C ATOM 4023 C2'URI 6 6.264 6.884-3. 257 1.00 0.00 C ATOM 4024 02'URI 6 5.323 6.691-4. 320 1.00 0.00 0 ATOM 4025 C3'URI 6 5.847 8.012-2. 340 1.00 0.00 C ATOM 4026 03'URI 6 4.425 7. 978-2.182 1.00 0.00 0 ATOM 4027 1H5'URI 6 6.678 11.306-2. 952 1.00 0.00 H ATOM 4028 2H5'URI 6 5.452 10.695-1. 823 1.00 0.00 H ATOM 4029 H4'URI 6 5.462 9.400-3. 932 1.00 0.00 H ATOM 4030 Hl'URI 6 7.764 7.032-4. 784 1.00 0.00 H ATOM 4031 H6 URI 6 8.466 8.622-1. 537 1.00 0.00 H ATOM 4032 H3 URI 6 10.957 4. 664-2.638 1.00 0. 00 H ATOM 4033 H5 URI 6 10.275 7.935-0. 073 1.00 0.00 H ATOM 4034 H2'URI 6 6.417 5.964-2. 693 1.00 0.00 H ATOM 4035 H02'URI 6 4. 447 6.698-3. 930 1.00 0. 00 H ATOM 4036 H3'URI 6 6.380 7.984-1. 388 1.00 0.00 H ATOM 4037 P CYT 7 3. 765 7.213-0. 926 1. 00 0. 00 P ATOM 4038 O1P CYT 7 2.303 7.446-0. 959 1.00 0.00 0 ATOM 4039 02P CYT 7 4.540 7.560 0.287 1.00 0.00 0 ATOM 4040 05'CYT 7 4.039 5.664-1. 272 1.00 0.00 0 ATOM 4041 C5'CYT 7 3.311 5.012-2. 318 1.00 0.00 C ATOM 4042 C4'CYT 7 3.983 3.711-2. 749 1.00 0.00 C ATOM 4043 04'CYT 7 5.348 3.920-3. 135 1.00 0.00 0 ATOM 4044 C1'CYT 7 6.154 2.822-2. 659 1. 00 0.00 C ATOM 4045 N1 CYT 7 7.123 3.259-1. 628 1.00 0.00 N ATOM 4046 C6 CYT 7 6.918 4.398-0. 903 1.00 0.00 C ATOM 4047 C2 CYT 7 8.239 2.459-1. 418 1.00 0.00 C ATOM 4048 02 CYT 7 8.403 1.435-2. 080 1.00 0.00 0 ATOM 4049 N3 CYT 7 9.133 2.836-0. 465 1.00 0.00 N ATOM 4050 C4 CYT 7 8. 944 3. 949 0.254 1.00 0.00 C ATOM 4051 N4 CYT 7 9.839 4.286 1.181 1.00 0.00 N ATOM 4052 C5 CYT 7 7.798 4.777 0.042 1.00 0.00 C ATOM 4053 C2'CYT 7 5.174 1.807-2. 082 1.00 0.00 C ATOM 4054 02'CYT 7 4.718 0.888-3. 084 1.00 0.00 O ATOM 4055 C3'CYT 7 4.059 2.714-1. 606 1.00 0.00 C ATOM 4056 03'CYT 7 2.842 1.962-1. 559 1.00 0.00 0 ATOM 4057 1H5'CYT 7 3.249 5.680-3. 177 1.00 0.00 H ATOM 4058 2H5'CYT 7 2.303 4.792-1. 966 1.00 0.00 H ATOM 4059 H4'CYT 7 3.436 3.273-3. 583 1. 00 0.00 H ATOM 4060 H1'CYT 7 6.689 2.374-3. 497 1.00 0.00 H ATOM 4061 H6 CYT 7 6.035 5.006-1. 092 1.00 0.00 H ATOM 4062 1H4 CYT 7 9.707 5.123 1.731 1.00 0.00 H ATOM 4063 2H4 CYT 7 10.650 3.703 1.334 1.00 0.00 H ATOM 4064 H5 CYT 7 7.642 5.685 0.625 1.00 0.00 H ATOM 4065 H2'CYT 7 5.626 1.279-1. 238 1. 00 0.00 H ATOM 4066 H02'CYT 7 4.409 1.408-3. 829 1.00 0.00 H ATOM 4067 H3'CYT 7 4.299 3.194-0. 656 1.00 0.00 H ATOM 4068 P ADE 8 2.393 1.221-0. 200 1.00 0.00 P ATOM 4069 01P ADE 8 2.305 2.236 0.874 1.00 0.00 0 ATOM 4070 02P ADE 8 1.224 0.365-0. 503 1. 00 0. 00 0 ATOM 4071 05'ADE 8 3.652 0.265 0.115 1.00 0.00 0

ATOM 4072 C5'ADE 8 3.953-0. 850-0.729 1.00 0.00 C ATOM 4073 C4'ADE 8 5.329-1. 437-0.417 1.00 0.00 C ATOM 4074 04'ADE 8 6.371-0. 460-0.576 1.00 0.00 0 ATOM 4075 C1'ADE 8 7.254-0. 514 0.561 1.00 0.00 C ATOM 4076 N9 ADE 8 7.054 0.647 1.454 1.00 0.00 N ATOM 4077 C4 ADE 8 7.902 1.075 2.453 1.00 0.00 C ATOM 4078 N3 ADE 8 9.079 0.516 2.800 1.00 0.00 N ATOM 4079 C2 ADE 8 9.649 1.175 3.806 1.00 0.00 C ATOM 4080 N1 ADE 8 9.178 2.252 4.434 1.00 0.00 N ATOM 4081 C6 ADE 8 8.002 2.792 4.070 1.00 0.00 C ATOM 4082 N6 ADE 8 7.549 3.868 4.712 1.00 0.00 N ATOM 4083 C5 ADE 8 7.310 2.181 3.019 1.00 0.00 C ATOM 4084 N7 ADE 8 6.092 2.467 2.395 1.00 0.00 N ATOM 4085 C8 ADE 8 6.027 1.532 1.509 1.00 0.00 C ATOM 4086 C2'ADE 8 6.918-1. 815 1.270 1.00 0.00 C ATOM 4087 02'ADE 8 7.598-2. 930 0.680 1.00 0.00 0 ATOM 4088 C3'ADE 8 5.426-1. 877 1.035 1.00 0.00 C ATOM 4089 03'ADE 8 4.991-3. 236 1.147 1.00 0.00 0 ATOM 4090 lH5'ADE 8 3.933-0. 527-1.770 1.00 0.00 H ATOM 4091 2H5'ADE 8 3.197-1. 621-0.583 1.00 0.00 H ATOM 4092 H4'ADE 8 5.526-2. 284-1.072 1.00 0.00 H ATOM 4093 H1'ADE 8 8.286-0. 542 0.223 1.00 0.00 H ATOM 4094 H2 ADE 8 10.606 0.790 4.159 1.00 0.00 H ATOM 4095 1H6 ADE 8 8.088 4.271 5.465 1.00 0.00 H ATOM 4096 2H6 ADE 8 6.666 4.280 4.446 1.00 0.00 H ATOM 4097 H8 ADE 8 5.177 1.454 0.832 1.00 0.00 H ATOM 4098 H2'ADE 8 7.138-1. 734 2.337 1.00 0.00 H ATOM 4099 H02'ADE 8 8.528-2. 850 0.907 1.00 0.00 H ATOM 4100 H3'ADE 8 4.885-1. 207 1.700 1.00 0.00 H ATOM 4101 P ADE 9 3.463-3. 576 1.533 1.00 0.00 P ATOM 4102 01P ADE 9 2.605-3. 228 0.378 1.00 0.00 0 ATOM 4103 02P ADE 9 3.423-4. 943 2.097 1. 00 0.00 0 ATOM 4104 05'. ADE 9 3.158-2. 530 2.722 1.00 0.00 0 ATOM 4105 C5'ADE 9 1.922-2. 585 3.444 1.00 0.00 C ATOM 4106 C4'ADE 9 1.827-1. 482 4.501 1.00 0.00 C ATOM 4107 04'ADE 9 2.942-1. 522 5.398 1.00 0.00 0 ATOM 4108 C1'ADE 9 3.855-0. 454 5.090 1.00 0.00 C ATOM 4109 N9 ADE 9 5.233-0. 968 4.967 1.00 0. 00 N ATOM 4110 C4 ADE 9 6.340-0. 515 5.644 1.00 0.00 C ATOM 4111 N3 ADE 9 6.374 0.500 6.524 1.00 0.00 N ATOM 4112 C2 ADE 9 7.598 0.680 7.003 1.00 0.00 C ATOM 4113 N1 ADE 9 8.697-0. 011 6.697 1.00 0.00 N ATOM 4114 C6 ADE 9 8.638-1. 022 5.814 1.00 0.00 C ATOM 4115 N6 ADE 9 9.745-1. 704 5.523 1.00 0.00 N ATOM 4116 C5 ADE 9 7.393-1. 305 5.244 1. 00 0.00 C ATOM 4117 N7 ADE 9 6.972-2. 259 4.315 1.00 0.00 N ATOM 4118 C8 ADE 9 5.714-1. 988 4.217 1.00 0.00 C ATOM 4119 C2'ADE 9 3.367 0.156 3.779 1.00 0.00 C ATOM 4120 02'ADE 9 3.666 1.554 3.700 1.00 0.00 O ATOM 4121 C3'ADE 9 1. 875-0. 093 3.870 1.00 0.00 C ATOM 4122 03'ADE 9 1.322 0.869 4.786 1.00 0.00 0 ATOM 4123 1H5'ADE 9 1.842-3. 554 3.937 1.00 0.00 H ATOM 4124 2H5'ADE 9 1.095-2. 476 2.742 1.00 0.00 H ATOM 4125 H4'ADE 9 0.907-1. 602 5.067 1. 00 0.00 H ATOM 4126 H1'ADE 9 3.815 0.299 5.878 1.00 0.00 H ATOM 4127 H2 ADE 9 7.715 1.474 7.733 1.00 0.00 H ATOM 4128 1H6 ADE 9 9.710-2. 466 4.861 1.00 0.00 H ATOM 4129 2H6 ADE 9 10.620-1. 460 5.966 1.00 0.00 H ATOM 4130 H8 ADE 9 5.065-2. 555 3.554 1. 00 0.00 H ATOM 4131 H2'ADE 9 3.783-0. 387 2.930 1.00 0.00 H

ATOM 4132 H02'ADE 9 3.237 1.980 4.446 1.00 0.00 H ATOM 4133 H3'ADE 9 1.392-0. 066 2.893 1.00 0.00 H ATOM 4134 P URI 10-0. 105 0.636 5.501 1.00 0.00 P ATOM 4135 O1P URI 10-0.540 1.919 6.098 1.00 0. 00 0 ATOM 4136 02P URI 10-0.991-0. 075 4.553 1.00 0.00 0 ATOM 4137 05'URI 10 0.275-0. 377 6.695 1.00 0.00 0 ATOM 4138 C5'URI 10-0.439-0. 362 7.934 1.00 0.00 C ATOM 4139 C4'URI 10 0.491-0. 053 9.105 1.00 0.00 C ATOM 4140 04'URI 10 1.001 1.288 9.030 1.00 0.00 0 ATOM 4141 C1'URI 10 0.490 2.066 10.126 1.00 0.00 C ATOM 4142 N1 URI 10 0.091 3.422 9.685 1.00 0.00 N ATOM 4143 C6 URI 10 0.010 3.735 8.354 1.00 0.00 C ATOM 4144 C2 URI 10-0.200 4.358 10.665 1.00 0.00 C ATOM 4145 02 URI 10-0.132 4.097 11.865 1.00 0.00 0 ATOM 4146 N3 URI 10-0.574 5. 611 10.216 1.00 0.00 N ATOM 4147 C4 URI 10-0.681 6.007 8.894 1.00 0.00 C ATOM 4148 04 URI 10-1.023 7.153 8.609 1.00 0.00 O ATOM 4149 C5 URI 10-0.359 4.969 7.941 1.00 0.00 C ATOM 4150 C2'URI 10-0.704 1.287 10.657 1.00 0.00 C ATOM 4151 02'URI 10-0.945 1.559 12.042 1.00 0. 00 0 ATOM 4152 C3'URI 10-0.245-0. 141 10. 437 1.00 0.00 C ATOM 4153 03'URI 10 0.708-0. 474 11.456 1.00 0.00 O ATOM 4154 1H5'URI 10-0.896-1. 339 8.091 1.00 0.00 H ATOM 4155 2H5'URI 10-1. 223 0.395 7.891 1.00 0.00 H ATOM 4156 H4'URI 10 1.323-0. 753 9.101 1.00 0.00 H ATOM 4157 H1'URI 10 1.249 2.144 10.906 1.00 0.00 H ATOM 4158 H6 URI 10 0.252 2.974 7.612 1.00 0.00 H ATOM 4159 H3 URI 10-0.789 6.303 10.919 1.00 0.00 H ATOM 4160 H5 URI 10-0.415 5.182 6.874 1.00 0.00 H ATOM 4161 H2'URI 10-1.591 1.493 10.050 1.00 0.00 H ATOM 4162 H02'URI 10-0.950 2.514 12.149 1.00 0.00 H ATOM 4163 H3'URI 10-1.078-0. 843 10.402 1.00 0.00 H ATOM 4164 P GUA 11 1.214-1. 992 11.653 1.00 0.00 P ATOM 4165 01P GUA 11 0.024-2. 871 11.727 1.00 0.00 0 ATOM 4166 02P GUA 11 2.210-2. 007 12.747 1.00 0.00 0 ATOM 4167 05'GUA 11 1.984-2. 293 10.268 1.00 0.00 0 ATOM 4168 C5'GUA 11 1.535-3. 333 9.390 1.00 0.00 C ATOM 4169 C4'GUA 11 2. 671-3. 868 8.521 1.00 0.00 C ATOM 4170 04'GUA 11 3.214-2. 851 7.665 1.00 0.00 0 ATOM 4171 C1'GUA 11 4.651-2. 865 7.759 1.00 0.00 C ATOM 4172 N9 GUA 11 5.137-1. 739 8.573 1.00 0.00 N ATOM 4173 C4 GUA 11 6.438-1. 494 8.937 1.00 0.00 C ATOM 4174 N3 GUA 11 7.506-2. 256 8.613 1.00 0.00 N ATOM 4175 C2 GUA 11 8.643-1. 766 9.108 1.00 0.00 C ATOM 4176 N2 GUA 11 9.794-2. 397 8.882 1.00 0.00 N ATOM 4177 N1 GUA 11 8.713-0. 613 9. 863 1.00 0.00 N ATOM 4178 C6 GUA 11 7.632 0.186 10.209 1.00 0.00 C ATOM 4179 06 GUA 11 7.803 1.196 10.887 1.00 0.00 0 ATOM 4180 C5 GUA 11 6.419-0. 329 9.686 1.00 0.00 C ATOM 4181 N7 GUA 11 5.115 0.162 9.798 1.00 0.00 N ATOM 4182 C8 GUA 11 4.448-0. 715 9.127 1.00 0.00 C ATOM 4183 C2'GUA 11 4.996-4. 197 8.408 1.00 0.00 C ATOM 4184 02'GUA 11 5.017-5. 262 7.449 1.00 0.00 O ATOM 4185 C3'GUA 11 3.841-4. 333 9.375 1.00 0.00 C ATOM 4186 03'GUA 11 3.658-5. 713 9.695 1.00 0.00 0 ATOM 4187 1H5'GUA 11 0.749-2. 942 8.746 1.00 0. 00 H ATOM 4188 2H5'GUA 11 1.131-4. 152 9.987 1.00 0.00 H ATOM 4189 H4'GUA 11 2.309-4. 696 7.914 1. 00 0.00 H ATOM 4190 H1'GUA 11 5.091-2. 811 6.763 1.00 0.00 H ATOM 4191 1H2 GUA 11 10.655-2. 026 9.256 1. 00 0. 00 H

ATOM 4192 2H2 GUA 11 9.805-3. 246 8.336 1.00 0.00 H ATOM 4193 H1 GUA 11 9.613-0. 309 10.202 1.00 0.00 H ATOM 4194 H8 GUA 11 3. 370-0.-637 9.010 1.00 0. 00 H ATOM 4195 H2'GUA 11 5.945-4. 126 8.947 1.00 0.00 H ATOM 4196 H02'GUA 11 4.181-5. 239 6.978 1.00 0. 00 H ATOM 4197 H3'GUA 11 3.976-3. 708 10. 260 1.00 0.00 H ATOM 4198 P CYT 12 3.911-6. 232 11.196 1.00 0. 00 P ATOM 4199 01P CYT 12 3.275-5. 277 12.130 1.00 0. 00 0 ATOM 4200 02P CYT 12 3.559-7. 668 11.254 1.00 0. 00 0 ATOM 4201 05'CYT 12 5. 508-6. 094 11.342 1.00 0. 00 0 ATOM 4202 C5'CYT 12 6.378-6. 994 10.650 1.00 0.00 C ATOM 4203 C4'CYT 12 7.846-6. 634 10.855 1.00 0.00 C ATOM 4204 04'CYT 12 8.156-5. 334 10.343 1.00 0. 00 0 ATOM 4205 C1'CYT 12 9.102-4. 690 11.222 1.00 0. 00 C ATOM 4206 N1 CYT 12 8.526-3. 472 11.838 1.00 0.00 N ATOM 4207 C6 CYT 12 7.190-3. 197 11.740 1.00 0.00 C ATOM 4208 C2 CYT 12 9.394-2. 618 12.509 1.00 0.00 C ATOM 4209 02 CYT 12 10.590-2. 890 12.596 1.00 0. 00 0 ATOM 4210 N3 CYT 12 8.882-1. 489 13.068 1.00 0.00 N ATOM 4211 C4 CYT 12 7.576-1. 206 12. 979 1.00 0. 00 C ATOM 4212 N4 CYT 12 7.112-0. 085 13.528 1.00 0.00 N ATOM 4213 C5 CYT 12 6.678-2. 083 12.293 1.00 0.00 C ATOM 4214 C2'CYT 12 9.463-5. 726 12.284 1.00 0.00 C ATOM 4215 02'CYT 12 10.596-6. 507 11.890 1.00 0.00 0 ATOM 4216 C3'CYT 12 8.199-6. 558 12.327 1.00 0.00 C ATOM 4217 03'CYT 12 8.518-7. 872 12.791 1.00 0.00 O ATOM 4218 1H5'CYT 12 6.149-6. 961 9. 584 1.00 0.00 H ATOM 4219 2H5'CYT 12 6.206-8. 006 11.019 1. 00 0. 00 H ATOM 4220 H4'CYT 12 8.477-7. 373 10.364 1.00 0.00 H ATOM 4221 H1'CYT 12 9.996-4. 424 10.657 1.00 0.00 H ATOM 4222 H6 CYT 12 6.534-3. 883 11.204 1.00 0.00 H ATOM 4223 1H4 CYT 12 6.130 0.143 13. 461 1.00 0.00 H ATOM 4224 2H4 CYT 12 7.744 0.541 14.008 1.00 0. 00 H ATOM 4225 H5 CYT 12 5.614-1. 857 12.222 1.00 0.00 H ATOM 4226 H2'CYT 12 9.635-5. 239 13.246 1.00 0.00 H ATOM 4227 H02'CYT 12 10.423-6. 831 11.003 1.00 0.00 H ATOM 4228 H3'CYT 12 7. 415-6. 078 12. 917 1.00 0.00 H ATOM 4229 P URI 13 8.259-8. 281 14.326 1.00 0.00 P ATOM 4230 O1P URI 13 6.960-7. 707 14.747 1.00 0.00 0 ATOM 4231 02P URI 13 8. 505-9. 733 14. 467 1.00 0.00 0 ATOM 4232 05'URI 13 9.431-7. 490 15.096 1.00 0.00 O ATOM 4233 C5'URI 13 10.795-7. 891 14.945 1.00 0.00 C ATOM 4234 C4'URI 13 11.753-6. 852 15.519 1.00 0. 00 C ATOM 4235 04'URI 13 11.617-5. 585 14.867 1.00 0.00 O ATOM 4236 C1'URI 13 11.765-4. 529 15.838 1.00 0.00 C ATOM 4237 N1 URI 13 10.529-3. 721 15.956 1.00 0.00 N ATOM 4238 C6 URI 13 9. 314-4. 220 15.565 1.00 0.00 C ATOM 4239 C2 URI 13 10.653-2. 440 16.465 1.00 0.00 C ATOM 4240 02 URI 13 11.733-1. 980 16. 831 1. 00 0. 00 0 ATOM 4241 N3 URI 13 9.487-1. 704 16.547 1.00 0.00 N ATOM 4242 C4 URI 13 8.225-2. 126 16.172 1.00 0.00 C ATOM 4243 04 URI 13 7. 258-1. 376 16.276 1.00 0.00 O ATOM 4244 C5 URI 13 8.185-3. 476 15.655 1.00 0.00 C ATOM 4245 C2'URI 13 12.103-5. 212 17.161 1.00 0.00 C ATOM 4246 02'URI 13 13.519-5. 329 17.345 1.00 0.00 O ATOM 4247 C3'URI 13 11. 449-6. 565 16.977 1.00 0.00 C ATOM 4248 03'URI 13 12.132-7. 525 17.788 1.00 0.00 O ATOM 4249 1H5'URI 13 11.013-8. 027 13.885 1.00 0.00 H ATOM 4250 2H5'URI 13 10.946-8. 838 15.464 1.00 0. 00 H ATOM 4251 H4'URI 13 12. 780-7. 201 15.419 1.00 0.00 H

ATOM 4252 Hl'URI 13 12.594-3. 883 15.543 1.00 0.00 H ATOM 4253 H6 URI 13 9. 252-5. 237 15.179 1.00 0.00 H ATOM 4254 H3 URI 13 9.564-0. 769 16.921 1.00 0.00 H ATOM 4255 H5 URI 13 7.234-3. 901 15.335 1.00 0.00 H ATOM 4256 H2'URI 13 11.641-4. 675 17.991 1.00 0.00 H ATOM 4257 H02'URI 13 13.871-5. 784 16.577 1.00 0.00 H ATOM 4258 H3'URI 13 10.376-6. 531 17.175 1.00 0.00 H ATOM 4259 P CYT 14 11.670-7. 781 19.308 1.00 0.00 P ATOM 4260 01P CYT 14 12.486-8. 886 19.861 1.00 0.00 0 ATOM 4261 02P CYT 14 10.192-7. 871 19.335 1.00 0.00 0 ATOM 4262 05'CYT 14 12.103-6. 414 20.041 1.00 0.00 0 ATOM 4263 C5'CYT 14 13.466-6. 184 20.410 1.00 0.00 C ATOM 4264 C4'CYT 14 13.636-4. 843 21.118 1.00 0.00 C ATOM 4265 04'CYT 14 13.283-3. 748 20.269 1.00 0.00 0 ATOM 4266 C1'CYT 14 12.629-2. 727 21.048 1.00 0.00 C ATOM 4267 N1 CYT 14 11.252-2. 480 20. 570 1.00 0.00 N ATOM 4268 C6 CYT 14 10.531-3. 465 19.961 1.00 0.00 C ATOM 4269 C2 CYT 14 10.723-1. 212 20.767 1.00 0.00 C ATOM 4270 02 CYT 14 11.389-0. 342 21.326 1.00 0.00 O ATOM 4271 N3 CYT 14 9.458-0. 966 20.333 1.00 0.00 N ATOM 4272 C4 CYT 14 8.739-1. 923 19.733 1.00 0.00 C ATOM 4273 N4 CYT 14 7.504-1. 647 19.318 1.00 0.00 N ATOM 4274 C5 CYT 14 9.279-3. 231 19.530 1.00 0.00 C ATOM 4275 C2'CYT 14 12.620-3. 224 22.492 1.00 0.00 C ATOM 4276 02'CYT 14 13.742-2. 721 23. 227 1.00 0.00 0 ATOM 4277 C3'CYT 14 12.699-4. 726 22.304 1.00 0. 00 C ATOM 4278 03'CYT 14 13.334-5. 300 23.450 1.00 0.00 O ATOM 4279 1H5'CYT 14 14.086-6. 194 19.513 1.00 0.00 H ATOM 4280 2H5'CYT 14 13.792-6. 982 21.078 1.00 0.00 H ATOM 4281 H4'CYT 14 14.667-4. 727 21.449 1.00 0.00 H ATOM 4282 H1'CYT 14 13.205-1. 803 20.988 1.00 0.00 H ATOM 4283 H6 CYT 14 10.971-4. 453 19.827 1.00 0.00 H ATOM 4284 1H4 CYT 14 6.954-2. 360 18.861 1.00 0.00 H ATOM 4285 2H4 CYT 14 7.116-0. 726 19.465 1.00 0.00 H ATOM 4286 H5 CYT 14 8.695-4. 013 19.049 1.00 0.00 H ATOM 4287 H2'CYT 14 11. 678-2. 952 22.976 1.00 0.00 H ATOM 4288 H02'CYT 14 13.600-1. 780 23.354 1.00 0.00 H ATOM 4289 H3'CYT 14 11.721-5. 165 22.101 1.00 0.00 H ATOM 4290 P URI 15 12.455-5. 803 24.702 1.00 0.00 P ATOM 4291 O1P URI 15 11.468-6. 789 24.208 1.00 0.00 0 ATOM 4292 02P URI 15 13.378-6. 169 25.800 1.00 0.00 0 ATOM 4293 05'URI 15 11.661-4. 468 25.130 1.00 0.00 0 ATOM 4294 C5'URI 15 12.323-3. 419 25.842 1.00 0.00 C ATOM 4295 C4'URI 15 11.422-2. 199 26.014 1.00 0.00 C ATOM 4296 04'URI 15 11.065-1. 617 24.751 1.00 0.00 O ATOM 4297 C1'URI 15 9.665-1. 270 24.760 1.00 0.00 C ATOM 4298 N1 URI 15 8.894-2. 141 23. 847 1.00 0.00 N ATOM 4299 C6 URI 15 9.209-3. 466 23.705 1.00 0.00 C ATOM 4300 C2 URI 15 7.842-1. 572 23.150 1.00 0.00 C ATOM 4301 02 URI 15 7.543-0. 386 23.266 1.00 0.00 O ATOM 4302 N3 URI 15 7.139-2. 418 22.313 1.00 0.00 N ATOM 4303 C4 URI 15 7.391-3. 764 22.114 1.00 0.00 C ATOM 4304 04 URI 15 6.700-4. 422 21.340 1.00 0.00 0 ATOM 4305 C5 URI 15 8.506-4. 273 22. 880 1.00 0.00 C ATOM 4306 C2'URI 15 9.206-1. 442 26.205 1.00 0.00 C ATOM 4307 02'URI 15 9.431-0. 253 26.974 1.00 0.00 O ATOM 4308 C3'URI 15 10.099-2. 578 26.657 1.00 0.00 C ATOM 4309 03'URI 15 10.247-2. 516 28.078 1.00 0.00 O ATOM 4310 1H5'URI 15 13.220-3. 125 25.296 1.00 0.00 H ATOM 4311 2H5'URI 15 12.612-3. 787 26.827 1.00 0. 00 H

ATOM 4312 H4'URI 15 11.926-1. 452 26.625 1.00 0. 00 H ATOM 4313 H1'URI 15 9.547-0. 228 24.461 1.00 0.00 H ATOM 4314 H6 URI 15 10.047-3. 878 24.265 1.00 0.00 H ATOM 4315 H3 URI 15 6.368-2. 016 21.799 1.00 0.00 H ATOM 4316 H5 URI 15 8.780-5. 324 22.798 1.00 0.00 H ATOM 4317 H2'URI 15 8.153-1. 743 26.241 1.00 0.00 H ATOM 4318 H02'URI 15 8.871 0.435 26.605 1.00 0.00 H ATOM 4319 H3'URI 15 9.734-3. 547 26.311 1.00 0.00 H ATOM 4320 P URI 16 9.058-3. 007 29.045 1.00 0.00 P ATOM 4321 O1P URI 16 8.420-4. 195 28.432 1.00 0.00 0 ATOM 4322 02P URI 16 9.586-3. 084 30.425 1.00 0.00 0 ATOM 4323 05'URI 16 8.017-1. 781 28.969 1.00 0.00 0 ATOM 4324 C5'URI 16 6.940-1. 683 29.904 1.00 0.00 C ATOM 4325 C4'URI 16 7.018-0. 399 30.716 1.00 0.00 C ATOM 4326 04'URI 16 8.341-0. 185 31.229 1.00 0.00 0 ATOM 4327 C1'URI 16 8.787 1.125 30.868 1.00 0.00 C ATOM 4328 N1 URI 16 10.251 1.152 30.657 1.00 0.00 N ATOM 4329 C6 URI 16 10. 850 0.295 29.771 1.00 0.00 C ATOM 4330 C2 URI 16 10.989 2.069 31.385 1.00 0.00 C ATOM 4331 02 URI 16 10.468 2.846 32.184 1.00 0.00 0 ATOM 4332 N3 URI 16 12.354 2.064 31.163 1.00 0.00 N ATOM 4333 C4 URI 16 13.037 1.235 30.290 1.00 0.00 C ATOM 4334 04 URI 16 14.257 1.318 30.173 1.00 0.00 0 ATOM 4335 C5 URI 16 12.190 0.310 29.571 1.00 0.00 C ATOM 4336 C2'URI 16 8.040 1.460 29.590 1.00 0.00 C ATOM 4337 02'URI 16 7.926 2. 874 29.398 1.00 0.00 0 ATOM 4338 C3'URI 16 6.687 0.816 29.847 1.00 0.00 C ATOM 4339 03'URI 16 5.887 1.711 30.625 1.00 0.00 0 ATOM 4340 1H5'URI 16 6.970-2. 533 30.575 1.00 0.00 H ATOM 4341 2H5'URI 16 5.999-1. 698 29.366 1.00 0.00 H ATOM 4342 H4'URI 16 6.316-0. 453 31.547 1.00 0.00 H ATOM 4343 H1'URI 16 8.513 1.835 31.649 1.00 0.00 H ATOM 4344 H6 URI 16 10.237-0. 413 29.214 1.00 0.00 H ATOM 4345 H3 URI 16 12.905 2.727 31.688 1. 00 0.00 H ATOM 4346 H5 URI 16 12.635-0. 384 28.859 1.00 0.00 H ATOM 4347 H2'URI 16 8.523 0.983 28.733 1.00 0.00 H ATOM 4348 H02'URI 16 7.362 3.015 28.634 1.00 0.00 H ATOM 4349 H3'URI 16 6.192 0.527 28. 918 1.00 0.00 H ATOM 4350 P CYT 17 4.360 1.336 30. 978 1.00 0.00 P ATOM 4351 01P CYT 17 4.349 0.045 31.702 1.00 0.00 O ATOM 4352 02P CYT 17 3.719 2.526 31.583 1.00 0.00 0 ATOM 4353 05'CYT 17 3.718 1.102 29.520 1. 00 0.00 0 ATOM 4354 C5'CYT 17 3.432 2.220 28.679 1.00 0.00 C ATOM 4355 C4'CYT 17 3.029 1.797 27.273 1.00 0.00 C ATOM 4356 04'CYT 17 4.045 0.989 26.662 1.00 0.00 0 ATOM 4357 Cl'CYT 17 3.440-0. 178 26.114 1.00 0.00 C ATOM 4358 N1 CYT 17 4.390-1. 306 26.064 1.00 0.00 N ATOM 4359 C6 CYT 17 4.916-1. 821 27.205 1.00 0.00 C ATOM 4360 C2 CYT 17 4.735-1. 807 24.815 1.00 0.00 C ATOM 4361 02 CYT 17 4.247-1. 321 23.795 1.00 0.00 0 ATOM 4362 N3 CYT 17 5.621-2. 838 24.757 1.00 0.00 N ATOM 4363 C4 CYT 17 6.148-3. 353 25.874 1.00 0.00 C ATOM 4364 N4 CYT 17 7.016-4. 361 25.784 1.00 0.00 N ATOM 4365 C5 CYT 17 5.793-2. 837 27.158 1.00 0.00 C ATOM 4366 C2'CYT 17 2.267-0. 463 27.033 1.00 0.00 C ATOM 4367 02'CYT 17 1. 276-1. 275 26. 392 1.00 0.00 0 ATOM 4368 C3'CYT 17 1.759 0.946 27.298 1.00 0.00 C ATOM 4369 03'CYT 17 0.936 1.344 26.196 1.00 0. 00 O ATOM 4370 1H5'CYT 17 4.313 2.851 28.617 1.00 0.00 H ATOM 4371 2H5'CYT 17 2.620 2.789 29.121 1.00 0.00 H

ATOM 4372 H4'CYT 17 2.858 2.682 26.662 1.00 0.00 H ATOM 4373 H1'CYT 17 3.076 0.036 25.117 1. 00 0.00 H ATOM 4374 H6 CYT 17 4.617-1. 409 28.168 1.00 0.00 H ATOM 4375 1H4 CYT 17 7.420-4. 756 26. 622 1.00 0.00 H ATOM 4376 2H4 CYT 17 7.269-4. 731 24.879 1.00 0. 00 H ATOM 4377 H5 CYT 17 6.227-3. 242 28.068 1.00 0.00 H ATOM 4378 H2'CYT 17 2.614-0. 919 27.964 1.00 0.00 H ATOM 4379 H02'CYT 17 0.479-1. 227 26.926 1.00 0.00 H ATOM 4380 H3'CYT 17 1.240 1.025 28.252 1.00 0.00 H ATOM 4381 P GUA 18-0.152 2.521 26.370 1.00 0.00 P ATOM 4382 01P GUA 18-1.488 1.895 26.487 1.00 0.00 0 ATOM 4383 02P GUA 18 0.319 3.444 27.426 1.00 0.00 0 ATOM 4384 05'GUA 18-0.084 3.288 24.952 1.00 0.00 0 ATOM 4385 C5'GUA 18 1.162 3.724 24. 388 1.00 0.00 C ATOM 4386 C4'GUA 18 1. 695 4.981 25.077 1. 00 0.00 C ATOM 4387 04'GUA 18 2.333 4.668 26.321 1. 00 0.00 0 ATOM 4388 C1'GUA 18 3.527 5.461 26.470 1.00 0.00 C ATOM 4389 N9 GUA 18 4.741 4.617 26.466 1.00 0.00 N ATOM 4390 C4 GUA 18 5.016 3.564 25.619 1.00 0.00 C ATOM 4391 N3 GUA 18 4.213 3.111 24.629 1.00 0.00 N ATOM 4392 C2 GUA 18 4.749 2.073 23.979 1.00 0.00 C ATOM 4393 N2 GUA 18 4.084 1.502 22.975 1.00 0.00 N ATOM 4394 N1 GUA 18 5.980 1.531 24.286 1.00 0.00 N ATOM 4395 C6 GUA 18 6.823 1.978 25.295 1.00 0. 00 C ATOM 4396 06 GUA 18 7.902 1.424 25.488 1.00 0.00 0 ATOM 4397 C5 GUA 18 6.261 3.081 25.992 1.00 0.00 C ATOM 4398 N7 GUA 18 6.774 3.817 27.063 1.00 0. 00 N ATOM 4399 C8 GUA 18 5.834 4.677 27.267 1.00 0.00 C ATOM 4400 C2'GUA 18 3.535 6.437 25.298 1.00 0.00 C ATOM 4401 02'GUA 18 2.866 7.660 25.628 1.00 0.00 0 ATOM 4402 C3'GUA 18 2.777 5.653 24.245 1.00 0.00 C ATOM 4403 03'GUA 18 2.155 6. 578 23.345 1.00 0.00 O ATOM 4404 1H5'GUA 18 1.010 3.940 23.331 1.00 0.00 H ATOM 4405 2H5'GUA 18 1.898 2.926 24.484 1.00 0.00 H ATOM 4406 H4'GUA 18 0.879 5.680 25.254 1.00 0.00 H ATOM 4407 Hl'GUA 18 3.476 6.017 27.407 1.00 0.00 H ATOM 4408 1H2 GUA 18 4.488 0.718 22.483 1.00 0.00 H ATOM 4409 2H2 GUA 18 3.177 1.855 22.705 1.00 0. 00 H ATOM 4410 H1 GUA 18 6.316 0.745 23.746 1.00 0.00 H ATOM 4411 H8 GUA 18 5.915 5.425 28.055 1.00 0.00 H ATOM 4412 H2'GUA 18 4. 560 6.626 24.968 1.00 0.00 H ATOM 4413 H02'GUA 18 2.692 8.122 24.805 1. 00 0. 00 H ATOM 4414 H3'GUA 18 3.415 4.930 23.735 1.00 0.00 H ATOM 4415 P GUA 19 2.426 6.498 21.758 1.00 0.00 P ATOM 4416 01P GUA 19 1.635 7.561 21.098 1. 00 0.00 0 ATOM 4417 02P GUA 19 2.269 5.090 21.332 1.00 0.00 0 ATOM 4418 05'GUA 19 3.987 6.887 21.643 1.00 0.00 0 ATOM 4419 C5'GUA 19 4.474 8.125 22.171 1.00 0.00 C ATOM 4420 C4'GUA 19 5.876 7.974 22. 760 1.00 0.00 C ATOM 4421 04'GUA 19 5.956 6.842 23.644 1.00 0.00 0 ATOM 4422 C1'GUA 19 7.111 6.051 23.305 1.00 0.00 C ATOM 4423 N9 GUA 19 6.731 4.834 22.559 1.00 0.00 N ATOM 4424 C4 GUA 19 7.540 3.754 22.281 1.00 0.00 C ATOM 4425 N3 GUA 19 8.823 3.600 22.680 1. 00 0. 00 N ATOM 4426 C2 GUA 19 9.349 2.448 22.253 1.00 0.00 C ATOM 4427 N2 GUA 19 10.609 2.139 22.557 1.00 0.00 N ATOM 4428 N1 GUA 19 8.657 1.525 21.494 1. 00 0.00 N ATOM 4429 C6 GUA 19 7.341 1.660 21.074 1. 00 0. 00 C ATOM 4430 06 GUA 19 6.815 0.780 20.399 1.00 0.00 0 ATOM 4431 C5 GUA 19 6.774 2.882 21. 523 1. 00 0. 00 C

ATOM 4432 N7 GUA 19 5.493 3.399 21.321 1.00 0.00 N ATOM 4433 C8 GUA 19 5.560 4.521 21.952 1.00 0.00 C ATOM 4434 C2'GUA 19 7.976 6.957 22.446 1.00 0.00 C ATOM 4435 02'GUA 19 8.773 7.840 23.245 1.00 0.00 O ATOM 4436 C3'GUA 19 6.909 7.704 21.674 1.00 0.00 C ATOM 4437 03'GUA 19 7.450 8.953 21.231 1.00 0.00 O ATOM 4438 1H5'GUA 19 3.797 8.471 22.951 1.00 0.00 H ATOM 4439 2H5'GUA 19 4.502 8.866 21.371 1.00 0.00 H ATOM 4440 H4'GUA 19 6.145 8.877 23.305 1.00 0.00 H ATOM 4441 H1'GUA 19 7.649 5.776 24.212 1.00 0.00 H ATOM 4442 1H2 GUA 19 11.165 2.775 23.109 1.00 0.00 H ATOM 4443 2H2 GUA 19 11.008 1.269 22.234 1.00 0.00 H ATOM 4444 Hl GUA 19 9.127 0.678 21.208 1.00 0.00 H ATOM 4445 H8 GUA 19 4.707 5.195 21.995 1.00 0.00 H ATOM 4446 H2'GUA 19 8.596 6.363 21.770 1.00 0.00 H ATOM 4447 H02'GUA 19 8.176 8.322 23.821 1.00 0.00 H ATOM 4448 H3'GUA 19 6.502 7.106 20.857 1.00 0.00 H ATOM 4449 P ADE 20 8.142 9.073 19.781 1.00 0.00 P ATOM 4450 01P ADE 20 8.669 10.448 19.633 1.00 0.00 0 ATOM 4451 02P ADE 20 7.204 8.530 18.774 1.00 0.00 O ATOM 4452 05'ADE 20 9.390 8.062 19. 904' 1.00 0.00 O ATOM 4453 C5'ADE 20 10.508 8.387 20.736 1.00 0.00 C ATOM 4454 C4'ADE 20 11.511 7.239 20.808 1.00 0.00 C ATOM 4455 04'ADE 20 10.919 6.043 21.333 1.00 0.00 0 ATOM 4456 C1'ADE 20 11.407 4.905 20.593 1.00 0.00 C ATOM 4457 N9 ADE 20 10.329 4.275 19.803 1.00 0.00 N ATOM 4458 C4 ADE 20 10.362 3.033 19.209 1.00 0.00 C ATOM 4459 N3 ADE 20 11.394 2.165 19.225 1.00 0.00 N ATOM 4460 C2 ADE 20 11.102 1.054 18.557 1.00 0.00 C ATOM 4461 N1 ADE. 20 9.960 0.767 17.930 1.00 0.00 N ATOM 4462 C6 ADE 20 8.944 1.647 17.929 1.00 0.00 C ATOM 4463 N6 ADE 20 7.806 1.333 17.312 1.00 0.00 N ATOM 4464 C5 ADE 20 9.140 2.857 18.602 1.00 0.00 C ATOM 4465 N7 ADE 20 8.323 3.975 18.798 1.00 0.00 N ATOM 4466 C8 ADE 20 9.092 4.739 19.499 1.00 0.00 C ATOM 4467 C2'ADE 20 12.506 5.442 19.685 1.00 0.00 C ATOM 4468 02'ADE 20 13.776 5.448 20.346 1.00 0.00 0 ATOM 4469 C3'ADE 20 12.003 6.845 19.427 1.00 0.00 C ATOM 4470 03'ADE 20 13.111 7.677 19.072 1.00 0.00 O ATOM 4471 lH5'ADE 20 10.151 8.609 21.742 1.00 0.00 H ATOM 4472 2H5'ADE 20 11.006 9.269 20.333 1.00 0.00 H ATOM 4473 H4'ADE 20 12.356 7.526 21.431 1.00 0.00 H ATOM 4474 H1'ADE 20 11.829 4.175 21.284 1.00 0.00 H ATOM 4475 H2 ADE 20 11.882 0.294 18.515 1.00 0.00 H ATOM 4476 1H6 ADE 20 7.034 1.984 17.315 1. 00 0.00 H ATOM 4477 2H6 ADE 20 7.713 0.441 16.846 1.00 0.00 H ATOM 4478 H8 ADE 20 8.764 5.725 19.823 1.00 0.00 H ATOM 4479 H2'ADE 20 12.545 4.870 18.756 1.00 0.00 H ATOM 4480 H02'ADE 20 14.290 6.166 19.970 1.00 0.00 H ATOM 4481 H3'ADE 20 11.204 6.863 18.684 1.00 0.00 H ATOM 4482 P GUA 21 13.549 7.829 17.530 1.00 0.00 P ATOM 4483 01P GUA 21 14.635 8.831 17.453 1.00 0.00 0 ATOM 4484 02P GUA 21 12.326 8.002 16.714 1.00 0.00 0 ATOM 4485 05'GUA 21 14.172 6.381 17.200 1.00 0.00 0 ATOM 4486 C5'GUA 21 15.482 6.033 17.657 1.00 0.00 C ATOM 4487 C4'GUA 21 15.898 4.647 17.175 1.00 0.00 C ATOM 4488 04'GUA 21 15.016 3.626 17.657 1.00 0.00 O ATOM 4489 C1'GUA 21 14.796 2.653 16.616 1.00 0.00 C ATOM 4490 N9 GUA 21 13.386 2.648 16.177 1.00 0.00 N ATOM 4491 C4 GUA 21 12.737 1.629 15.515 1.00 0.00 C

ATOM 4492 N3 GUA 21 13.294 0.465 15.110 1.00 0.00 N ATOM 4493 C2 GUA 21 12.414-0. 328 14.492 1.00 0.00 C ATOM 4494 N2 GUA 21 12.801-1. 510 14.014 1.00 0.00 N ATOM 4495 Nl GUA 21 11.090 0.007 14.295 1.00 0.00 N ATOM 4496 C6 GUA 21 10.495 1.193 14.701 1.00 0.00 C ATOM 4497 06 GUA 21 9.300 1.388 14.490 1.00 0.00 0 ATOM 4498 C5 GUA 21 11.424 2.044 15.356 1.00 0.00 C ATOM 4499 N7 GUA 21 11.239 3.315 15.908 1.00 0.00 N ATOM 4500 C8 GUA 21 12.419 3.582 16.354 1.00 0.00 C ATOM 4501 C2'GUA 21 15.728 3.042 15.473 1.00 0.00 C ATOM 4502 02'GUA 21 17.009 2.412 15.601 1.00 0.00 0 ATOM 4503 C3'GUA 21 15.820 4.542 15.663 1.00 0.00 C ATOM 4504 03'GUA 21 17.052 5.011 15.106 1.00 0.00 0 ATOM 4505 1H5'GUA 21 15.496 6.048 18.747 1.00 0.00 H ATOM 4506 2H5'GUA 21 16.195 6.767 17.282 1.00 0.00 H ATOM 4507 H4'GUA 21 16.913 4.431 17.505 1.00 0.00 H ATOM 4508 H1'GUA 21 15.065 1.662 16.982 1.00 0.00 H ATOM 4509 1H2 GUA 21 13.761-1. 808 14.121 1.00 0.00 H ATOM 4510 2H2 GUA 21 12.137-2. 107 13.542 1.00 0.00 H ATOM 4511 H1 GUA 21 10.487-0. 650 13.822 1.00 0.00 H ATOM 4512 H8 GUA 21 12.636 4.532 16.841 1.00 0.00 H ATOM 4513 H2'GUA 21 15.267 2.806 14.514 1.00 0.00 H ATOM 4514 H02'GUA 21 16.921 1.517 15.265 1.00 0.00 H ATOM 4515 H3'GUA 21 14.948 5.059 15.259 1.00 0.00 H ATOM 4516 P ADE 22 17.115 5.545 13.586 1.00 0.00 P ATOM 4517 O1P ADE 22 15.824 6.196 13.268 1.00 0.00 0 ATOM 4518 02P ADE 22 18.380 6.291 13.410 1.00 0.00 0 ATOM 4519 05'ADE 22 17.211 4.179 12.740 1.00 0.00 0 ATOM 4520 C5'ADE 22 18.368 3.344 12.839 1.00 0.00 C ATOM 4521 C4'ADE 22 18.076 1.921 12.374 1.00 0.00 C ATOM 4522 04'ADE 22 16.979 1.348 13.096 1.00 0. 00 0 ATOM 4523 C1'ADE 22 16.131 0.622 12.187 1.00 0.00 C ATOM 4524 N9 ADE 22 14.813 1.271 12.039 1.00 0.00 N ATOM 4525 C4 ADE 22 13.654 0.670 11.611 1.00 0.00 C ATOM 4526 N3 ADE 22 13.512-0. 619 11.246 1.00 0.00 N ATOM 4527 C2 ADE 22 12.263-0. 883 10.885 1.00 0.00 C ATOM 4528 N1 ADE 22 11.235-0. 033 10.862 1.00 0.00 N ATOM 4529 C6 ADE 22 11.401 1.248 11.231 1.00 0.00 C ATOM 4530 N6 ADE 22 10.361 2.080 11.202 1.00 0.00 N ATOM 4531 C5 ADE 22 12. 680 1.640 11.632 1.00 0.00 C ATOM 4532 N7 ADE 22 13.203 2.861 12.068 1.00 0.00 N ATOM 4533 C8 ADE 22 14.437 2.553 12.279 1.00 0.00 C ATOM 4534 C2'ADE 22 16.873 0.588 10.857 1.00 0.00 C ATOM 4535 02'ADE 22 17.746-0. 544 10.772 1.00 0.00 0 ATOM 4536 C3'ADE 22 17.646 1.889 10.917 1.00 0.00 C ATOM 4537 03'ADE 22 18.812 1.768 10.095 1.00 0.00 0 ATOM 4538 lH5'ADE 22 18.699 3.316 13.878 1.00 0.00 H ATOM 4539 2H5'ADE 22 19.164 3.763 12.224 1.00 0.00 H ATOM 4540 H4'ADE 22 18.960 1.300 12.510 1.00 0.00 H ATOM 4541 Hl'ADE 22 15.996-0. 396 12.552 1.00 0.00 H ATOM 4542 H2 ADE 22 12.055-1. 906 10.570 1.00 0.00 H ATOM 4543 1H6 ADE 22 10.478 3.044 11.478 1.00 0.00 H ATOM 4544 2H6 ADE 22 9.455 1.746 10.905 1.00 0.00 H ATOM 4545 H8 ADE 22 15.150 3.296 12.635 1.00 0.00 H ATOM 4546 H2'ADE 22 16.163 0.603 10.025 1.00 0.00 H ATOM 4547 H02'ADE 22 18.319-0. 521 11.542 1.00 0.00 H ATOM 4548 H3'ADE 22 17.027 2.747 10.649 1.00 0.00 H ATOM 4549 P CYT 23 18.723 2.020 8.506 1.00 0.00 P ATOM 4550 01P CYT 23 20.077 1.847 7.934 1.00 0.00 0 ATOM 4551 02P CYT 23 17.981 3.280 8.276 1.00 0.00 0

ATOM 4552 05'CYT 23 17.803 0.797 8.003 1.00 0.00 0 ATOM 4553 C5'CYT 23 18.312-0. 541 7.982 1.00 0.00 C ATOM 4554 C4'CYT 23 17.284-1. 526 7.433 1.00 0.00 C ATOM 4555 04'CYT 23 16.083-1. 520 8.200 1.00 0.00 0 ! ATOM 4556 C1'CYT 23 14.970-1. 835 7.343 1.00 0.00 C ATOM 4557 N1 CYT 23 13.884-0. 839 7.488 1.00 0.00 N ATOM 4558 C6 CYT 23 14.163 0.480 7.710 1.00 0.00 C ATOM 4559 C2 CYT 23 12.575-1. 296 7.395 1.00 0.00 C ATOM 4560 02 CYT 23 12.347-2. 488 7.193 1.00 0.00 0 ATOM 4561 N3 CYT 23 11.566-0. 394 7. 531 1.00 0.00 N ATOM 4562 C4 CYT 23 11.824 0.901 7.749 1.00 0.00 C ATOM 4563 N4 CYT 23 10.810 1.755 7.877 1.00 0.00 N ATOM 4564 C5 CYT 23 13.169 1.378 7.845 1.00 0.00 C ATOM 4565 C2'CYT 23 15.510-1. 861 5.907 1.00 0.00 C ATOM. 4566 02'CYT 23 15.682-3. 203 5.438 1.00 0.00 O ATOM 4567 C3'CYT 23 16.843-1. 138 6.036 1.00 0.00 C ATOM 4568 03'CYT 23 17.772-1. 702 5.102 1.00 0.00 0 ATOM 4569 1H5'CYT 23 18.580-0. 836 8.997 1.00 0.00 H ATOM 4570 2H5'CYT 23 19.204-0. 572 7.356 1.00 0.00 H ATOM 4571 H4'CYT 23 17.702-2. 531 7.422 1.00 0.00 H ATOM 4572 H1'CYT 23 14.589-2. 823 7.600 1.00 0.00 H ATOM 4573 H6 CYT 23 15.200 0.808 7.777 1.00 0.00 H ATOM 4574 1H4 CYT 23 10.992 2.735 8.042 1.00 0.00 H ATOM 4575 2H4 CYT 23 9.858 1.423 7.809 1.00 0.00 H ATOM 4576 H5 CYT 23 13.382 2.432 8.021 1.00 0.00 H ATOM 4577 H2'CYT 23 14.842-1. 301 5.246 1.00 0.00 H ATOM 4578 H02'CYT 23 15.946-3. 151 4.517 1.00 0.00 H ATOM 4579 H3'CYT 23 16.736-0. 059 5.922 1.00 0.00 H ATOM 4580 P GUA 24 17.867-1. 149 3.592 1.00 0.00 P ATOM 4581 01P GUA 24 17.389 0.252 3.577 1.00 0.00 0 ATOM 4582 02P GUA 24 19.212-1. 475 3.065 1.00 0.00 0 ATOM 4583 05'GUA 24 16.787-2. 058 2.819 1.00 0.00 0 ATOM 4584 C5'GUA 24 17.035-3. 449 2.590 1.00 0.00 C ATOM 4585 C4'GUA 24 15.936-4. 084 1.744 1.00 0.00 C ATOM 4586 04'GUA 24 14.644-3. 941 2.359 1.00 0.00 0 ATOM 4587 C1'GUA 24 13.709-3. 433 1.391 1.00 0.00 C ATOM 4588 N9 GUA 24 13.437-2. 001 1.608 1.00 0.00 N ATOM 4589 C4 GUA 24 12.486-1. 248 0.965 1.00 0.00 C ATOM 4590 N3 GUA 24 11.633-1. 696 0.016 1.00 0.00 N ATOM 4591 C2 GUA 24 10.823-0. 733-0.427 1.00 0.00 C ATOM 4592 N2 GUA 24 9.924-1. 002-1.373 1.00 0.00 N ATOM 4593 N1 GUA 24 10.857 0.566 0.036 1.00 0.00 N ATOM 4594 C6 GUA 24 11.722 1.050 1.007 1.00 0.00 C ATOM 4595 06 GUA 24 11.674 2.230 1.344 1.00 0.00 0 ATOM 4596 C5 GUA 24 12.588 0.033 1.483 1.00 0.00 C ATOM 4597 N7 GUA 24 13.597 0.094 2.449 1.00 0.00 N ATOM 4598 C8 GUA 24 14.029-1. 121 2.453 1.00 0.00 C ATOM 4599 C2'GUA 24 14.367-3. 663 0.041 1.00 0.00 C ATOM 4600 02'GUA 24 14.173-5. 006-0.420 1.00 0.00 0 ATOM 4601 C3'GUA 24 15.813-3. 393 0.393 1.00 0.00 C ATOM 4602 03'GUA 24 16.654-4. 066-0.548 1.00 0.00 0 ATOM 4603 1H5'GUA 24 17.089-3. 965 3.549 1.00 0.00 H ATOM 4604 2H5'GUA 24 17.989-3. 559 2.073 1.00 0.00 H ATOM 4605 H4'GUA 24 16.150-5. 142 1.596 1.00 0.00 H ATOM 4606 Hl'GUA 24 12.775-3. 993 1.445 1.00 0.00 H ATOM 4607 1H2 GUA 24 9.857-1. 934-1.755 1.00 0.00 H ATOM 4608 2H2 GUA 24 9.310-0. 273-1.709 1.00 0.00 H ATOM 4609 H1 GUA 24 10.207 1.233-0. 346 1.00 0. 00 H ATOM 4610 H8 GUA 24 14.842-1. 429 3.110 1. 00 0.00 H ATOM 4611 H2'GUA 24 14.004-2. 936-0.688 1.00 0. 00 H

ATOM 4612 H02'GUA 24 14.504-5. 593 0.263 1.00 0.00 H ATOM 4613 H3'GUA 24 16.024-2. 324 0.458 1.00 0.00 H ATOM 4614 P ADE 25 17.244-3. 276-1.821 1.00 0.00 P ATOM 4615 O1P ADE 25 18.159-4. 185-2.547 1.00 0.00 0 ATOM 4616 02P ADE 25 17.727-1. 954-1.364 1.00 0.00 0 ATOM 4617 05'ADE 25 15.934-3. 047-2.728 1.00 0.00 0 ATOM 4618 C5'ADE 25 15.342-4. 140-3.435 1.00 0. 00 C ATOM 4619 C4'ADE 25 14.042-3. 734-4.123 1.00 0.00 C ATOM 4620 04'ADE 25 13.068-3. 256-3.185 1.00 0.00 0 ATOM 4621 C1'ADE 25 12.420-2. 088-3.727 1.00 0.00 C ATOM 4622 N9 ADE 25 12.825-0. 866-3.005 1.00 0.00 N ATOM 4623 C4 ADE 25 12.229 0.372-3. 088 1.00 0.00 C ATOM 4624 N3 ADE 25 11.160 0.695-3. 842 1.00 0.00 N ATOM 4625 C2 ADE 25 10.835 1.975-3. 696 1.00 0.00 C ATOM 4626 N1 ADE 25 11.442 2.877-2. 923 1.00 0.00 N ATOM 4627 C6 ADE 25 12.508 2.530-2. 180 1.00 0.00 C ATOM 4628 N6 ADE 25 13.101 3.446-1. 417 1.00 0.00 N ATOM 4629 C5 ADE 25 12.941 1.204-2. 256 1.00 0.00 C ATOM 4630 N7 ADE 25 13.988 0.514-1. 638 1.00 0.00 N ATOM 4631 C8 ADE 25 13.844-0. 670-2.131 1.00 0.00 C ATOM 4632 C2'ADE 25 12.852-2. 021-5.184 1.00 0.00 C ATOM 4633 02'ADE 25 12.021-2. 836-6. 020 1.00 0.00 0 ATOM 4634 C3'ADE 25 14. 256-2. 572-5.079 1.00 0.00 C ATOM 4635 03'ADE 25 14.653-3. 081-6.354 1.00 0.00 O ATOM 4636 1H5'ADE 25 15.134-4. 947-2.732 1.00 0.00 H ATOM 4637 2H5'ADE 25 16.045-4. 498-4.187 1.00 0.00 H ATOM 4638 H4'ADE 25 13.633-4. 584-4.666 1.00 0.00 H ATOM 4639 Hl'ADE 25 11.338-2. 208-3. 669 1.00 0.00 H ATOM 4640 H2 ADE 25 9.981 2.328-4. 275 1.00 0.00 H ATOM 4641 1H6 ADE 25 13.903 3.194-0. 858 1.00 0.00 H ATOM 4642 2H6 ADE 25 12.748 4.392-1. 396 1.00 0.00 H ATOM 4643 H8 ADE 25 14.520-1. 480-1.860 1.00 0.00 H ATOM 4644 H2'ADE 25 12.870-0. 984-5.530 1.00 0.00 H ATOM 4645 H02'ADE 25 12.019-3. 720-5.646 1.00 0.00 H ATOM 4646 H3'ADE 25 14.954-1. 832-4.683 1.00 0.00 H ATOM 4647 P CYT 26 15.286-2. 092-7.455 1.00 0.00 P ATOM 4648 01P CYT 26 15.586-2. 880-8.671 1.00 0.00 0 ATOM 4649 02P CYT 26 16.354-1. 298-6.807 1.00 0.00 0 ATOM 4650 05'CYT 26 14.055-1. 106-7.780 1.00 0.00 0 ATOM 4651 C5'CYT 26 12.948-1. 564-8.561 1.00 0.00 C ATOM 4652 C4'CYT 26 11.994-0. 425-8.907 1.00 0.00 C ATOM 4653 04'CYT 26 11.338 0.106-7. 748 1.00 0.00 0 ATOM 4654 C1'CYT 26 11.247 1.541-7. 873 1.00 0.00 C ATOM 4655 N1 CYT 26 12.084 2.221-6. 864 1.00 0.00 N ATOM 4656 C6 CYT 26 13.232 1.646-6. 406 1.00 0.00 C ATOM 4657 C2 CYT 26 11.674 3.474-6. 425 1.00 0.00 C ATOM 4658 02 CYT 26 10.633 3.971-6. 853 1.00 0.00 0 ATOM 4659 N3 CYT 26 12.451 4.125-5. 519 1.00 0.00 N ATOM 4660 C4 CYT 26 13.582 3.573-5. 063 1.00 0.00 C ATOM 4661 N4 CYT 26 14.320 4.239-4. 177 1.00 0.00 N ATOM 4662 C5 CYT 26 14.006 2.282-5. 514 1.00 0.00 C ATOM 4663 C2'CYT 26 11.734 1.867-9. 281 1.00 0.00 C ATOM 4664 02'CYT 26 10.668 1.808-10. 237 1.00 0.00 0 ATOM 4665 C3'CYT 26 12.741 0.758-9. 492 1.00 0.00 C ATOM 4666 03'CYT 26 12.918 0.540-10. 894 1.00 0.00 0 ATOM 4667 1H5'CYT 26 12.405-2. 325-8.001 1.00 0.00 H ATOM 4668 2H5'CYT 26 13.325-2. 002-9.485 1.00 0.00 H ATOM 4669 H4'CYT 26 11.246-0. 774-9.617 1.00 0.00 H ATOM 4670 Hl'CYT 26 10.211 1.855-7. 761 1.00 0.00 H ATOM 4671 H6 CYT 26 13. 522 0.656-6. 761 1. 00 0.00 H

ATOM 4672 1H4 CYT 26 15.176 3.834-3. 825 1.00 0.00 H ATOM 4673 2H4 CYT 26 14.024 5.151-3. 859 1.00 0.00 H ATOM 4674 H5 CYT 26 14.933 1.837-5. 166 1.00 0.00 H ATOM 4675 H2'CYT 26 12.228 2.843-9. 296 1.00 0.00 H ATOM 4676 H02'CYT 26 10.242 0.953-10. 136 1. 00 0.00 H ATOM 4677 H3'CYT 26 13.681 0.953-8. 966 1.00 0.00 H ATOM 4678 P CYT 27 14.369 0.713-11. 570 1.00 0.00 P ATOM 4679 01P CYT 27 14.296 0.208-12. 960 1.00 0.00 0 ATOM 4680 02P CYT 27 15.384 0. 170-10. 639 1.00 0.00 0 ATOM 4681 05'CYT 27 14.538 2.313-11. 622 1.00 0.00 0 ATOM 4682 C5'CYT 27 13.633 3.111-12. 391 1.00 0.00 C ATOM 4683 C4'CYT 27 13.441 4.496-11. 781 1.00 0.00 C ATOM 4684 04'CYT 27 13.031 4.423-10. 411 1.00 0.00 0 ATOM 4685 C1'CYT 27 13.623 5.520-9. 682 1.00 0.00 C ATOM 4686 N1 CYT 27 14.517 5.048-8. 601 1.00 0.00 N ATOM 4687 C6 CYT 27 15.061 3.795-8. 621 1.00 0.00 C ATOM 4688 C2 CYT 27 14.809 5.946-7. 583 1.00 0.00 C ATOM 4689 02 CYT 27 14.306 7.067-7. 587 1.00 0. 00. O ATOM 4690 N3 CYT 27 15.659 5.554-6. 598 1.00 0.00 N ATOM 4691 C4 CYT 27 16.204 4.332-6. 605 1.00 0.00 C ATOM 4692 N4 CYT 27 17.031 3.984-5. 620 1.00 0.00 N ATOM 4693 C5 CYT 27 15.907 3.399-7. 648 1.00 0.00 C ATOM 4694 C2'CYT 27 14.409 6.335-10. 709 1.00 0.00 C ATOM 4695 02'CYT 27 13.612 7.385-11. 269 1.00 0.00 0 ATOM 4696 C3'CYT 27 14.741 5.275-11. 737 1.00 0.00 C ATOM 4697 03'CYT 27 14.951 5.911-13. 002 1.00 0.00 O ATOM 4698 1H5'CYT 27 12.666 2.608-12. 437 1.00 0.00 H ATOM 4699 2H5'CYT 27 14.026 3.219-13. 402 1. 00 0.00 H ATOM 4700 H4'CYT 27 12.698 5.052-12. 350 1.00 0.00 H ATOM 4701 Hl'CYT 27 12.832 6.140-9. 257 1.00 0.00 H ATOM 4702 H6 CYT 27 14.800 3.106-9. 425 1.00 0.00 H ATOM 4703 1H4 CYT 27 17.447 3.064-5. 610 1.00 0.00 H ATOM 4704 2H4 CYT 27 17.240 4.642-4. 882 1.00 0.00 H ATOM 4705 H5 CYT 27 16.356 2.404-7. 659 1.00 0.00 H ATOM 4706 H2'CYT 27 15.323 6.730-10. 259 1.00 0.00 H ATOM 4707 H02'CYT 27 14.103 7.752-12. 008 1. 00 0. 00 H ATOM 4708 H3'CYT 27 15.584 4.655-11. 429 1.00 0.00 H ATOM 4709 P GUA 28 16.407 6.479-13. 393 1.00 0.00 P ATOM 4710 01P GUA 28 16.339 7.017-14. 770 1.00 0.00 O ATOM 4711 02P GUA 28 17.413 5.448-13. 054 1.00 0.00 O ATOM 4712 05'GUA 28 16.588 7.714-12. 372 1.00 0.00 O ATOM 4713 C5'GUA 28 16.388 9. 061-12. 812 1.00 0.00 C ATOM 4714 C4'GUA 28 17.229 10.049-12. 006 1.00 0.00 C ATOM 4715 04'GUA 28 16.841 10.087-10. 631 1.00 0.00 O ATOM 4716 C1'GUA 28 18.010 10.295-9. 812 1.00 0.00 C ATOM 4717 N9 GUA 28 18.198 9.182-8. 859 1.00 0.00 N ATOM 4718 C4 GUA 28 18.915 9.221-7. 683 1.00 0.00 C ATOM 4719 N3 GUA 28 19. 590 10.289-7. 201 1.00 0.00 N ATOM 4720 C2 GUA 28 20.191 10.025-6. 038 1.00 0.00 C ATOM 4721 N2 GUA 28 20.907 10.970-5. 429 1.00 0.00 N ATOM 4722 N1 GUA 28 20.126 8.801-5. 403 1.00 0.00 N ATOM 4723 C6 GUA 28 19.441 7.690-5. 877 1.00 0.00 C ATOM 4724 06 GUA 28 19.448 6.642-5. 236 1.00 0.00 0 ATOM 4725 C5 GUA 28 18.800 7.962-7. 116 1.00 0. 00 C ATOM 4726 N7 GUA 28 18.018 7.128-7. 922 1.00 0.00 N ATOM 4727 C8 GUA 28 17.718 7.915-8. 900 1. 00 0.00 C ATOM 4728 C2'GUA 28 19.195 10.406-10. 772 1.00 0.00 C ATOM 4729 02'GUA 28 19.479 11.772-11. 100 1.00 0.00 O ATOM 4730 C3'GUA 28 18.688 9. 637-11.976 1.00 0.00 C ATOM 4731 03'GUA 28 19.332 10.137-13. 152 1.00 0.00 O

ATOM 4732 1H5'GUA 28 15.334 9.320-12. 703 1.00 0.00 H ATOM 4733 2H5'GUA 28 16.665 9.136-13. 864 1. 00 0.00 H ATOM 4734 H4'GUA 28 17.138 11.046-12. 435 1.00 0.00 H ATOM 4735 H1'GUA 28 17.903 11.230-9. 261 1.00 0.00 H ATOM 4736 1H2 GUA 28 20.995 11.885-5. 848 1.00 0.00 H ATOM 4737 2H2 GUA 28 21.359 10.773-4. 548 1.00 0.00 H ATOM 4738 H1 GUA 28 20.603 8.683-4. 521 1.00 0.00 H ATOM 4739 H8 GUA 28 17.103 7.572-9. 731 1.00 0.00 H ATOM 4740 H2'GUA 28 20.073 9.913-10. 348 1.00 0.00 H ATOM 4741 H02'GUA 28 18.670 12.157-11. 445 1.00 0.00 H ATOM 4742 H3'GUA 28 18. 809 8.559-11. 854 1.00 0.00 H ATOM 4743 P CYT 29 20.646 9.410-13. 735 1.00 0.00 P ATOM 4744 01P CYT 29 20.965 10.013-15. 049 1.00 0.00 0 ATOM 4745 02P CYT 29 20.455 7.947-13. 622 1.00 0.00 0 ATOM 4746 05'CYT 29 21.785 9.851-12. 685 1.00 0.00 O ATOM 4747 C5'CYT 29 22.455 11.107-12. 822 1.00 0.00 C ATOM 4748 C4'CYT 29 23.539 11.286-11. 762 1.00 0.00 C ATOM 4749 04'CYT 29 22.989 11.290-10. 440 1. 00 0.00 O ATOM 4750 C1'CYT 29 23.846 10.540-9. 558 1. 00 0.00 C ATOM 4751 N1 CYT 29 23.167 9.322-9. 057 1.00 0.00 N ATOM 4752 C6 CYT 29 22. 255 8.657-9. 827 1.00 0.00 C ATOM 4753 C2 CYT 29 23.484 8. 889-7.776 1. 00 0.00 C ATOM 4754 02 CYT 29 24.312 9.501-7. 103 1.00 0.00 O ATOM 4755 N3 CYT 29 22.860 7.779-7. 296. 1.00 0.00 N ATOM 4756 C4 CYT 29 21. 964 7. 118-8. 039 1.00 0.00 C ATOM 4757 N4 CYT 29 21. 372 6.034-7. 537 1.00 0.00 N ATOM 4758 C5 CYT 29 21.634 7.558-9. 359 1.00 0.00 C ATOM 4759 C2'CYT 29 25.089 10. 187-10. 373 1.00 0.00 C ATOM 4760 02'CYT 29 26.100 11. 195-10. 252 1.00 0.00 O ATOM 4761 C3'CYT 29 24.522 10.129-11. 777 1.00 0.00 C ATOM 4762 03'CYT 29 25.563 10.428-12. 713 1.00 0.00 O ATOM 4763 1H5'CYT 29 21.727 11.913-12. 726 1.00 0.00 H ATOM 4764 2H5'CYT 29 22.914 11.159-13. 810 1.00 0.00 H ATOM 4765 H4'CYT 29 24.070 12.221-11. 935 1.00 0. 00 H ATOM 4766 Hl'CYT 29 24.134 11.168-8. 714 1.00 0.00 H ATOM 4767 H6 CYT 29 22.028 9.019-10. 830 1.00 0.00 H ATOM 4768 1H4 CYT 29 20.695 5.527-8. 088 1.00 0.00 H ATOM 4769 2H4 CYT 29 21.600 5.721-6. 604 1.00 0.00 H ATOM 4770 H5 CYT 29 20.904 7.021-9. 966 1.00 0.00 H ATOM 4771 H2'CYT 29 25.471 9.208-10. 075 1.00 0.00 H ATOM 4772 H02'CYT 29 25.714 12.023-10. 550 1.00 0.00 H ATOM 4773 H3'CYT 29 24.033 9.175-11. 981 1.00 0.00 H ATOM 4774 P CYT 30 25.823 9.476-13. 988 1.00 0.00 P ATOM 4775 01P CYT 30 26.268 10.324-15. 116 1.00 0. 00 O ATOM 4776 02P CYT 30 24.651 8.586-14. 151 1.00 0.00 O ATOM 4777 05'CYT 30 27.072 8.580-13. 506 1.00 0.00 O ATOM 4778 C5'CYT 30 28.340 9.185-13. 232 1.00 0.00 C ATOM 4779 C4'CYT 30 28.905 8.723-11. 891 1.00 0.00 C ATOM 4780 04'CYT 30 27.971 8.929-10. 827 1.00 0. 00 0 ATOM 4781 C1'CYT 30 28.055 7.830-9. 902 1.00 0.00 C ATOM 4782 N1 CYT 30 26.785 7.070-9. 846 1.00 0.00 N ATOM 4783 C6 CYT 30 26.019 6.888-10. 963 1.00 0.00 C ATOM 4784 C2 CYT 30 26.408 6.543-8. 618 1. 00 0. 00 C ATOM 4785 02 CYT 30 27.112 6.721-7. 625 1.00 0.00 O ATOM 4786 N3 CYT 30 25.250 5.833-8. 547 1.00 0.00 N ATOM 4787 C4 CYT 30 24.490 5.644-9. 633 1.00 0.00 C ATOM 4788 N4 CYT 30 23.367 4.936-9. 527 1.00 0.00 N ATOM 4789 C5 CYT 30 24.871 6.186-10. 901 1.00 0.00 C ATOM 4790 C2'CYT 30 29.203 6. 952-10.398 1.00 0. 00 C ATOM 4791 02'CYT 30 30.450 7.342-9. 810 1.00 0.00 0

ATOM 4792 C3'CYT 30 29.177 7.229-11. 887 1.00 0.00 C ATOM 4793 03'CYT 30 30.426 6.910-12. 513 1.00 0.00 O ATOM 4794 1H5'CYT 30 28.222 10.269-13. 211 1.00 0.00 H ATOM 4795 2H5'CYT 30 29.040 8.919-14. 024 1.00 0.00 H ATOM 4796 H4'CYT 30 29.825 9.264-11. 673 1.00 0.00 H ATOM 4797 H1'CYT 30 28.295 8.212-8. 909 1.00 0.00 H ATOM 4798 H6 CYT 30 26.337 7.316-11. 913 1. 00 0.00 H ATOM 4799 1H4 CYT 30 22.787 4.783-10. 340 1.00 0.00 H ATOM 4800 2H4 CYT 30 23.097 4.547-8. 634 1.00 0.00 H ATOM 4801 H5 CYT 30 24.253 6. 036-11. 787 1.00 0.00 H ATOM 4802 H2'CYT 30 28.987 5.898-10. 201 1.00 0.00 H ATOM 4803 H02'CYT 30 30.392 7.158-8. 870 1.00 0.00 H ATOM 4804 H3'CYT 30 28.348 6.691-12. 355 1.00 0.00 H ATOM 4805 H03'CYT 30 30.551 5.961-12. 433 1.00 0.00 H TER ATOM 4806 05'GUA 1-7.009 7.326-5. 619 1.00 0.00 0 ATOM 4807 C5'GUA 1-6. 866 8.278-4. 560 1.00 0.00 C ATOM 4808 C4'GUA 1-7.122 7.644-3. 195 1.00 0.00 C ATOM 4809 04'GUA 1-8.439 7.075-3. 120 1.00 0.00 O ATOM 4810 C1'GUA 1-8. 359 5.739-2. 593 1.00 0.00 C ATOM 4811 N9 GUA 1-8.558 4.732-3. 653 1.00 0.00 N ATOM 4812 C4 GUA 1-8.822 3.393-3. 475 1.00 0.00 C ATOM 4813 N3 GUA 1-8.950 2.761-2. 286 1.00 0.00 N ATOM 4814 C2 GUA 1-9.204 1.458-2. 431 1.00 0.00 C ATOM 4815 N2 GUA 1-9.351 0.684-1. 356 1.00 0.00 N ATOM 4816 N1 GUA 1-9.321 0.833-3. 657 1.00 0.00 N ATOM 4817 C6 GUA 1-9.194 1.459-4. 890 1.00 0.00 C ATOM 4818 06 GUA 1-9.313 0.809-5. 926 1.00 0.00 O ATOM 4819 C5 GUA 1-8.923 2.845-4. 744 1.00 0.00 C ATOM 4820 N7 GUA 1-8.726 3.826-5. 720 1.00 0.00 N ATOM 4821 C8 GUA 1-8.522 4.876-4. 999 1.00 0.00 C ATOM 4822 C2'GUA 1-6.970 5.625-1. 987 1.00 0.00 C ATOM 4823 02'GUA 1-6.935 6.138-0. 650 1.00 0.00 0 ATOM 4824 C3'GUA 1-6.167 6.486-2. 939 1.00 0.00 C ATOM 4825 03'GUA 1-5. 016 6.982-2. 248 1.00 0.00 0 ATOM 4826 H5'GUA 1-6.820 7.784-6. 441 1.00 0. 00 H ATOM 4827 1H5'GUA 1-7.576 9.090-4. 714 1.00 0.00 H ATOM 4828 2H5'GUA 1-5.853 8.682-4. 580 1.00 0.00 H ATOM 4829 H4'GUA 1-7.007 8.394-2. 414 1.00 0. 00 H ATOM 4830 Hl'GUA 1-9.110 5.607-1. 814 1.00 0.00 H ATOM 4831 1H2 GUA 1-9.271 1.083-0. 432 1.00 0. 00 H ATOM 4832 2H2 GUA 1-9.542-0. 302-1.466 1.00 0. 00 H ATOM 4833 H1 GUA 1-9.514-0. 157-3.682 1.00 0.00 H ATOM 4834 H8 GUA 1-8.320 5.844-5. 456 1.00 0.00 H ATOM 4835 H2'GUA 1-6.624 4.589-2. 023 1.00 0.00 H ATOM 4836 H02'GUA 1-6.093 6.584-0. 538 1.00 0.00 H ATOM 4837 H3'GUA 1-5.911 5.952-3. 856 1.00 0.00 H ATOM 4838 P GUA 2-3.623 6.173-2. 294 1.00 0.00 P ATOM 4839 01P GUA 2-3.277 5.926-3. 712 1.00 0.00 0 ATOM 4840 02P GUA 2-2.658 6.863-1. 409 1.00 0.00 0 ATOM 4841 05'GUA 2-4.011 4.763-1. 619 1.00 0.00 0 ATOM 4842 C5'GUA 2-4.257 4.674-0. 212 1.00 0.00 C ATOM 4843 C4'GUA 2-4.748 3.286 0.191 1.00 0.00 C ATOM 4844 04'GUA 2-5.934 2.913-0. 510 1.00 0.00 0 ATOM 4845 C1'GUA 2-5.929 1.487-0. 725 1.00 0.00 C ATOM 4846 N9 GUA 2-6.047 1.159-2. 162 1.00 0.00 N ATOM 4847 C4 GUA 2-6.356-0. 071-2.700 1.00 0.00 C ATOM 4848 N3 GUA 2-6.583-1. 207-2.002 1. 00 0.00 N ATOM 4849 C2 GUA 2-6.862-2. 243-2.799 1.00 0.00 C ATOM 4850 N2 GUA 2-7.105-3. 442-2. 271 1.00 0. 00 N

ATOM 4851 N1 GUA 2-6.913-2. 159-4.177 1.00 0. 00 N ATOM 4852 C6 GUA 2-6. 684-1. 006-4. 916 1.00 0.00 C ATOM 4853 06 GUA 2-6.758-1. 035-6.142 1.00 0.00 O ATOM 4854 C5 GUA 2-6.385 0.101-4. 075 1.00 0.00 C ATOM 4855 N7 GUA 2-6.094 1. 428-4.410 1.00 0.00 N ATOM 4856 C8 GUA 2-5.914 1.960-3. 249 1.00 0.00 C ATOM 4857 C2'GUA 2-4.610 0.967-0. 146 1. 00 0.00 C ATOM 4858 02'GUA 2-4.782 0.474 1.189 1. 00 0.00 0 ATOM 4859 C3'GUA 2-3.744 2.212-0. 174 1.00 0.00 C ATOM 4860 03'GUA 2-2.770 2.126 0.870 1. 00 0.00 O ATOM 4861 1H5'GUA 2-5.011 5.411 0.065 1. 00 0.00 H ATOM 4862 2H5'GUA 2-3.333 4.893 0.323 1.00 0.00 H ATOM 4863 H4'GUA 2-4.940 3.261 1.263 1.00 0.00 H ATOM 4864 H1'GUA 2-6.761 1.038-0. 182 1.00 0.00 H ATOM 4865 1H2 GUA 2-7.078-3. 568-1.269 1.00 0.00 H ATOM 4866 2H2 GUA 2-7.317-4. 225-2. 872 1.00 0.00 H ATOM 4867 H1 GUA 2-7.137-2. 988-4.708 1.00 0.00 H ATOM 4868 H8 GUA 2-5.666 3. 017-3. 145 1.00 0.00 H ATOM 4869 H2'GUA 2-4.190 0.198-0. 797 1.00 0. 00 H ATOM 4870 H02'GUA 2-3.908 0.286 1.537 1.00 0.00 H ATOM 4871 H3'GUA 2-3.298 2.376-1. 156 1.00 0.00 H ATOM 4872 P CYT 3-1.326 1.474 0.588 1.00 0.00 P ATOM 4873 01P CYT 3-0.456 1.755 1.753 1.00 0.00 O ATOM 4874 02P CYT 3-0.892 1.871-0. 770 1. 00 0.00 O ATOM 4875 05'CYT 3-1. 655-0. 101 0.570 1. 00 0.00 O ATOM 4876 C5'CYT 3-1.652-0. 862 1.780 1.00 0.00 C ATOM 4877 C4'CYT 3-1.782-2. 355 1.499 1.00 0.00 C ATOM 4878 04'CYT 3-3. 045-2. 674 0.897 1.00 0. 00 0 ATOM 4879 C1'CYT 3-2.837-3. 583-0.201 1.00 0.00 C ATOM 4880 N1 CYT 3-3. 066-2. 914-1.503 1.00 0.00 N ATOM 4881 C6 CYT 3-2.749-1. 598-1.682 1. 00 0.00 C ATOM 4882 C2 CYT 3-3.608-3. 674-2.531 1.00 0.00 C ATOM 4883 02 CYT 3-3. 880-4. 859-2.348 1.00 0. 00 O ATOM 4884 N3 CYT 3-3. 820-3. 074-3.734 1.00 0.00 N ATOM 4885 C4 CYT 3-3.513-1. 784-3. 923 1.00 0.00 C ATOM 4886 N4 CYT 3-3.735-1. 227-5.113 1.00 0.00 N ATOM 4887 C5 CYT 3-2. 953-0. 999-2.867 1.00 0.00 C ATOM 4888 C2'CYT 3-1.394-4. 055-0.075 1.00 0.00 C ATOM 4889 02'CYT 3-1. 280-5. 171 0.817 1.00 0.00 O ATOM. 4890 C3'CYT 3-0.739-2. 814 0. 493 1. 00 0.00 C ATOM 4891 03'CYT 3 0.447-3. 192 1.199 1. 00 0.00 O ATOM 4892 1H5'CYT 3-2.485-0. 543 2.407 1.00 0.00 H ATOM 4893 2H5'CYT 3-0.717-0. 681 2. 311 1.00 0.00 H ATOM 4894 H4'CYT 3-1.671-2. 916 2.425 1.00 0.00 H ATOM 4895 H1'CYT 3-3. 510-4. 435-0. 102 1. 00 0.00 H ATOM 4896 H6 CYT 3-2.334-1. 022-0. 855 1.00 0.00 H ATOM 4897 1H4 CYT 3-3.508-0. 255-5.266 1.00 0.00 H ATOM 4898 2H4 CYT 3-4.130-1. 778-5.862 1.00 0.00 H ATOM 4899 H5 CYT 3-2. 691 0. 047-3. 018 1.00 0.00 H ATOM 4900 H2'CYT 3-0.982-4. 290-1.059 1.00 0. 00 H ATOM 4901 H02'CYT 3-1.670-5. 929 0.375 1.00 0.00 H ATOM 4902 H3'CYT 3-0.552-2. 062-0.279 1.00 0.00 H ATOM 4903 P GUA 4 1.890-3. 061 0.498 1.00 0. 00 P ATOM 4904 01P GUA 4 1.972-1. 734-0.153 1.00 0.00 O ATOM 4905 02P GUA 4 2.921-3. 466 1.481 1.00 0.00 O ATOM 4906 05'GUA 4 1.821-4. 183-0.654 1.00 0.00 O ATOM 4907 C5'GUA 4 1.846-5. 573-0.316 1.00 0.00 C ATOM 4908 C4'GUA 4 1.437-6. 448-1.497 1.00 0.00 C ATOM 4909 04'GUA 4 0.118-6. 147-1.953 1.00 0.00 0 ATOM 4910 C1'GUA 4 0.048-6. 384-3.374 1.00 0. 00 C

ATOM 4911 N9 GUA 4-0.415-5. 186-4.102 1.00 0.00 N ATOM 4912 C4 GUA 4-0.928-5. 159-5.378 1. 00 0.00 C ATOM 4913 N3 GUA 4-1. 101-6. 230-6.182 1.00 0.00 N ATOM 4914 C2 GUA 4-1.616-5. 897-7.366 1.00 0.00 C ATOM 4915 N2 GUA 4-1.842-6. 839-8. 279 1.00 0.00 N ATOM 4916 N1 GUA 4-1.938-4. 602-7.725 1.00 0.00 N ATOM 4917 C6 GUA 4-1.771-3. 484-6.916 1.00 0.00 C ATOM 4918 06 GUA 4-2.094-2. 372-7.328 1.00 0.00 0 ATOM 4919 C5 GUA 4-1.220-3. 832-5.653 1.00 0.00 C ATOM 4920 N7 GUA 4-0.894-3. 021-4.561 1.00 0.00 N ATOM 4921 C8 GUA 4-0.439-3. 886-3.717 1.00 0.00 C ATOM 4922 C2'GUA 4 1.459-6. 780-3.817 1.00 0.00 C ATOM 4923 02'GUA 4 1.600-8. 203-3. 898 1.00 0.00 0 ATOM 4924 C3'GUA 4 2.311-6. 195-2.708 1.00 0.00 C ATOM 4925 03'GUA 4 3.508-6. 971-2.584 1.00 0.00 0 ATOM 4926 1H5'GUA 4 1.161-5. 751 0.512 1.00 0.00 H ATOM 4927 2H5'GUA 4 2.856-5. 844-0.007 1.00 0.00 H ATOM 4928 H4'GUA 4 1.491-7. 498-1.215 1. 00 0.00 H ATOM 4929 H1'GUA 4-0.635-7. 211-3.567 1.00 0.00 H ATOM 4930 1H2 GUA 4-1.624-7. 803-8.074 1.00 0.00 H ATOM 4931 2H2 GUA 4-2.227-6. 590-9.177 1.00 0.00 H ATOM 4932 H1 GUA 4-2.322-4. 431-8.643 1.00 0.00 H ATOM 4933 H8 GUA 4-0.083-3. 581-2.734 1.00 0.00 H ATOM 4934 H2'GUA 4 1.701-6. 307-4. 772 1.00 0.00 H ATOM 4935 H02'GUA 4 2. 538-8.392-3. 964 1.00 0.00 H ATOM 4936 H3'GUA 4 2.509-5. 133-2.859 1.00 0.00 H ATOM 4937 P CYT 5 4.798-6. 633-3.489 1.00 0.00 P ATOM 4938 01P CYT 5 5.950-7. 391-2.952 1.00 0.00 O ATOM 4939 02P CYT 5 4.888-5. 163-3.640 1.00 0.00 0 ATOM 4940 05'CYT 5 4.400-7. 262-4.917 1.00 0.00 O ATOM 4941 C5'CYT 5 4.546-8. 664-5.160 1.00 0.00 C ATOM 4942 C4'CYT 5 4.098-9. 042-6. 569 1.00 0.00 C ATOM 4943 04'CYT 5 2.727-8. 697-6.803 1.00 0.00 O ATOM 4944 C1'CYT 5 2.583-8. 176-8.139 1.00 0.00 C ATOM 4945 N1 CYT 5 2.183-6. 750-8.120 1.00 0.00 N ATOM 4946 C6 CYT 5 2.652-5. 900-7.159 1.00 0.00 C ATOM 4947 C2 CYT 5 1.315-6. 311-9.113 1.00 0.00 C ATOM 4948 02 CYT 5 0.904-7. 094-9.968 1. 00 0. 00 0 ATOM 4949 N3 CYT 5 0.938-5. 003-9.107 1.00 0.00 N ATOM 4950 C4 CYT 5 1.389-4. 159-8.171 1.00 0.00 C ATOM 4951 N4 CYT 5 0.998-2. 886-8.196 1.00 0.00 N ATOM 4952 C5 CYT 5 2.283-4. 605-7.147 1.00 0.00 C ATOM 4953 C2'CYT 5 3.942-8. 359-8.811 1.00 0.00 C ATOM 4954 02'CYT 5 4. 038-9. 630-9.465 1.00 0.00 0 ATOM 4955 C3'CYT 5 4.875-8. 271-7.620 1.00 0.00 C ATOM 4956 03'CYT 5 6.078-8. 988-7.915 1.00 0.00 O ATOM 4957 1H5'CYT 5 3.946-9. 217-4.437 1.00 0.00 H ATOM 4958 2H5'CYT 5 5.594-8. 939-5.036 1.00 0.00 H ATOM 4959 H4'CYT 5 4.232-10. 111-6.724 1.00 0.00 H ATOM 4960 Hl'CYT 5 1.834-8. 757-8.676 1.00 0.00 H ATOM 4961 H6 CYT 5 3.330-6. 274-6.392 1.00 0.00 H ATOM 4962 1H4 CYT 5 0.367-2. 566-8.917 1.00 0.00 H ATOM 4963 2H4 CYT 5 1.333-2. 241-7.495 1. 00 0.00 H ATOM 4964 H5 CYT 5 2.652-3. 921-6.384 1.00 0.00 H ATOM 4965 H2'CYT 5 4.133-7. 541-9.509 1.00 0. 00 H ATOM 4966 H02'CYT 5 3.857-10. 305-8.807 1.00 0.00 H ATOM 4967 H3'CYT 5 5. 062-7.238-7. 322 1.00 0.00 H ATOM 4968 P URI 6 7.383-8. 211-8.450 1. 00 0.00 P ATOM 4969 O1P URI 6 7.439-6. 887-7.790 1.00 0.00 0 ATOM 4970 02P URI 6 8.540-9. 131-8.358 1.00 0.00 O

ATOM 4971 05'URI 6 7.039-7. 984-10.005 1.00 0.00 O ATOM 4972 C5'URI 6 6.999-9. 093-10.907 1.00 0.00 C ATOM 4973 C4'URI 6 6.468-8. 684-12.278 1.00 0.00 C ATOM 4974 04'URI 6 5.138-8. 153-12.196 1.00 0.00 0 ATOM 4975 C1'URI 6 5.025-7. 010-13. 068 1.00 0. 00 C ATOM 4976 N1 URI 6 4.849-5. 755-12.300 1.00 0.00 N ATOM 4977 C6 URI 6 5.341-5. 626-11.027 1.00 0.00 C ATOM 4978 C2 URI 6 4.171-4. 717-12.919 1.00 0.00 C ATOM 4979 02 URI 6 3.726-4. 812-14.062 1.00 0.00 0 ATOM 4980 N3 URI 6 4. 024-3.560-12. 178 1.00 0.00 N ATOM 4981 C4 URI 6 4.488-3. 347-10.893 1.00 0.00 C ATOM 4982 04 URI 6 4.298-2. 272-10.329 1.00 0.00 0 ATOM 4983 C5 URI 6 5.184-4. 478-10.323 1.00 0.00 C ATOM 4984 C2'URI 6 6.316-6. 982-13.878 1.00 0.00 C ATOM 4985 02'URI 6 6.216-7. 793-15.055 1.00 0.00 O ATOM 4986 C3'URI 6 7.294-7. 561-12. 880 1.00 0.00 C ATOM 4987 03'URI 6 8.402-8. 124-13.588 1.00 0.00 O ATOM 4988 1H5'URI 6 6.352-9. 867-10.492 1.00 0.00 H ATOM 4989 2H5'URI 6 8. 006-9. 495-11.022 1.00 0.00 H ATOM 4990 H4'URI 6 6.473-9. 544-12.946 1.00 0.00 H ATOM 4991 Hl'URI 6 4.180-7. 148-13.741 1.00 0.00 H ATOM 4992 H6 URI 6 5.867-6. 464-10. 570 1.00 0.00 H ATOM 4993 H3 URI 6 3.532-2. 796-12.618 1.00 0.00 H ATOM 4994 H5 URI 6 5.593-4. 404-9.315 1.00 0.00 H ATOM 4995 H2'URI 6 6.584-5. 954-14.128 1.00 0.00 H ATOM 4996 H02'URI 6 5.978-8. 679-14. 772 1.00 0. 00 H ATOM 4997 H3'URI 6 7.598-6. 827-12.132 1.00 0.00 H ATOM 4998 P CYT 7 9.734-7. 253-13.840 1.00 0.00 P ATOM 4999 O1P CYT 7 10.076-6. 553-12.581 1.00 0.00 0 ATOM 5000 02P CYT 7 10.737-8. 121-14.497 1.00 0.00 O ATOM 5001 05'CYT 7 9.238-6. 155-14.909 1.00 0.00 0 ATOM 5002 C5'CYT 7 8.929-6. 538-16.252 1.00 0.00 C ATOM 5003 C4'CYT 7 8.079-5. 487-16.961 1.00 0. 00 C ATOM 5004 04'CYT 7 6.883-5. 187-16. 232 1.00 0.00 O ATOM 5005 C1'CYT 7 6.578-3. 784-16.379 1.00 0.00 C ATOM 5006 N1 CYT 7 6.613-3. 071-15. 083 1.00 0.00 N ATOM 5007 C6 CYT 7 7.313-3. 565-14.019 1.00 0. 00 C ATOM 5008 C2 CYT 7 5.922-1. 870-15.000 1.00 0. 00 C ATOM 5009 02 CYT 7 5.299-1. 444-15.971 1.00 0. 00 O ATOM 5010 N3 CYT 7 5.958-1. 185-13.826 1.00 0.00 N ATOM 5011 C4 CYT 7 6.641-1. 654-12.776 1.00 0.00 C ATOM 5012 N4 CYT 7 6.656-0. 952-11.646 1.00 0.00 N ATOM 5013 C5 CYT 7 7. 353-2. 892-12. 854 1.00 0.00 C ATOM 5014 C2'CYT 7 7.633-3. 224-17.329 1.00 0. 00 C ATOM 5015 02'CYT 7 7.202-3. 298-18.693 1.00 0.00 0 ATOM 5016 C3'CYT 7 8.796-4. 154-17.060 1.00 0. 00 C ATOM 5017 03'CYT 7 9.652-4. 162-18.208 1.00 0.00 0 ATOM 5018 1H5'CYT 7 8.383-7. 482-16.235 1.00 0.00 H ATOM 5019 2H5'CYT 7 9.859-6. 675-16.805 1. 00 0.00 H ATOM 5020 H4'CYT 7 7.815-5. 837-17.957 1.00 0.00 H ATOM 5021 H1'CYT 7 5.590-3. 673-16.829 1.00 0. 00 H ATOM 5022 H6 CYT 7 7.846-4. 511-14.114 1.00 0. 00 H ATOM 5023 1H4 CYT 7 7.169-1. 292-10.846 1.00 0.00 H ATOM 5024 2H4 CYT 7 6.154-0. 076-11.591 1.00 0. 00 H ATOM 5025 H5 CYT 7 7.909-3. 277-11.999 1.00 0.00 H ATOM 5026 H2'CYT 7 7.889-2. 198-17. 050 1.00 0.00 H ATOM 5027 H02'CYT 7 7.943-3. 627-19.208 1.00 0.00 H ATOM 5028 H3'CYT 7 9.323-3. 898-16.139 1.00 0.00 H ATOM 5029 P ADE 8 10.882-3. 124-18. 317 1.00 0.00 P ATOM 5030 01P ADE 8 11.722-3. 273-17.108 1.00 0.00 0

ATOM 5031 02P ADE 8 11.489-3. 265-19.660 1.00 0.00 0 ATOM 5032 05'ADE 8 10.147-1. 691-18.244 1.00 0.00 0 ATOM 5033 C5'ADE 8 9.244-1. 277-19.275 1. 00 0. 00 C ATOM 5034 C4'ADE 8 8. 373-0. 105-18. 827 1.00 0.00 C ATOM 5035 04'ADE 8 7.693-0. 391-17. 593 1.00 0.00 O ATOM 5036 C1'ADE 8 7.801 0.746-16. 715 1.00 0.00 C ATOM 5037 N9 ADE 8 8.735 0.483-15. 600 1.00 0.00 N ATOM 5038 C4 ADE 8 8.817 1.176-14. 410 1.00 0. 00 C ATOM 5039 N3 ADE 8 8.047 2.218-14. 033 1.00 0.00 N ATOM 5040 C2 ADE 8 8.387 2. 659-12. 823 1.00 0.00 C ATOM 5041 N1 ADE 8 9.351 2. 183-12. 034 1.00 0.00 N ATOM 5042 C6 ADE 8 10.105 1.144-12. 432 1.00 0.00 C ATOM 5043 N6 ADE 8 11.067 0.689-11. 630 1.00 0.00 N ATOM 5044 C5 ADE 8 9.836 0.596-13. 691 1.00 0.00 C ATOM 5045 N7 ADE 8 10.408-0. 462-14.404 1.00 0.00 N ATOM 5046 C8 ADE 8 9.710-0. 453-15.490 1.00 0.00 C ATOM 5047 C2'ADE 8 8.299 1.885-17. 588 1.00 0.00 C ATOM 5048 02'ADE 8 7.223 2.524-18. 286 1. 00 0.00 0 ATOM 5049 C3'ADE 8 9.209 1.129-18. 530 1.00 0.00 C ATOM 5050 03'ADE 8 9.371 1.887-19. 733 1.00 0.00 0 ATOM 5051 1H5'ADE 8 8. 600-2. 114-19. 541 1.00 0.00 H ATOM 5052 2H5'ADE 8 9.819-0. 979-20.152 1.00 0.00 H ATOM 5053 H4'ADE 8 7.639 0.125-19. 598 1.00 0.00 H ATOM 5054 H1'ADE 8 6.822 0.996-16. 318 1.00 0.00 H ATOM 5055 H2 ADE 8 7.815 3.502-12. 433 1.00 0.00 H ATOM 5056 1H6 ADE 8 11.220 1.121-10. 730 1.00 0.00 H ATOM 5057 2H6 ADE 8 11.644-0. 087-11.922 1.00 0.00 H ATOM 5058 H8 ADE 8 9.896-1. 171-16.288 1. 00 0.00 H ATOM 5059 H2'ADE 8 8.867 2.601-16. 991 1.00 0.00 H ATOM 5060 H02'ADE 8 7.613 3.072-18. 972 1.00 0.00 H ATOM 5061 H3'ADE 8 10.158 0.875-18. 060 1.00 0.00 H ATOM 5062 P ADE 9 10.713 1.745-20. 614 1.00 0.00 P ATOM 5063 01P ADE 9 10.767 2.881-21. 561 1.00 0.00 O ATOM 5064 02P ADE 9 10.791 0.357-21. 124 1.00 0.00 0 ATOM 5065 05'ADE 9 11.877 1.946-19. 516 1.00 0.00 0 ATOM 5066 C5'ADE 9 13.255 2.002-19. 907 1.00 0.00 C ATOM 5067 C4'ADE 9 14.192 1.947-18. 698 1.00 0.00 C ATOM 5068 04'ADE 9 13.897 2.986-17. 760 1.00 0.00 O ATOM 5069 C1'ADE 9 13.214 2.434-16. 620 1.00 0. 00 C ATOM 5070 N9 ADE 9 11.996 3.210-16. 315 1.00 0.00 N ATOM 5071 C4 ADE 9 11.657 3.764-15. 105 1.00 0.00 C ATOM 5072 N3 ADE 9 12.367 3.682-13. 967 1.00 0. 00 N ATOM 5073 C2 ADE 9 11.766 4.329-12. 977 1.00 0. 00 C ATOM 5074 N1 ADE 9 10.611 4.994-13. 028 1. 00 0.00 N ATOM 5075 C6 ADE 9 9.919 5.062-14. 177 1. 00 0. 00 C ATOM 5076 N6 ADE 9 8.766 5.731-14. 210 1.00 0.00 N ATOM 5077 C5 ADE 9 10.460 4.415-15. 292 1.00 0. 00 C ATOM 5078 N7 ADE 9 10.025 4.281-16. 613 1.00 0.00 N ATOM 5079 C8 ADE 9 10.973 3. 572-17. 127 1.00 O*00 C ATOM 5080 C2'ADE 9 12. 878 0.993-16. 986 1. 00 0. 00 C ATOM 5081 02'ADE 9 12.859 0.143-15. 833 1.00 0.00 0 ATOM 5082 C3'ADE 9 14.020 0.648-17. 918 1.00 0. 00 C ATOM 5083 03'ADE 9 15.189 0.412-17. 115 1. 00 0.00 0 ATOM 5084 1H5'ADE 9 13.431 2.932-20. 449 1.00 0. 00 H ATOM 5085 2H5'ADE 9 13.473 1.161-20. 565 1.00 0.00 H ATOM 5086 H4'ADE 9 15. 223 2.046-19. 033 1.00 0.00 H ATOM 5087 H1'ADE 9 13.880 2.442-15. 756 1.00 0.00 H ATOM 5088 H2 ADE 9 12.279 4.325-12. 021 1.00 0.00 H ATOM 5089 1H6 ADE 9 8.239 5. 787-15. 069 1.00 0. 00 H ATOM 5090 2H6 ADE 9 8.420 6.182-13. 375 1.00 0. 00 H

ATOM 5091 H8 ADE 9 10.944 3.265-18. 171 1.00 0.00 H ATOM 5092 H2'ADE 9 11.932 0.950-17. 525 1.00 0.00 H ATOM 5093 H02'ADE 9 13.735 0.174-15. 441 1.00 0.00 H ATOM 5094 H3'ADE 9 13.782-0. 194-18.567 1.00 0.00 H ATOM 5095 P URI 10 16.670 0.408-17. 753 1.00 0.00 P ATOM 5096 01P URI 10 17.580-0. 273-16.806 1.00 0.00 O ATOM 5097 02P URI 10 16.575-0. 062-19.154 1.00 0.00 0 ATOM 5098 05'URI 10 17.038 1.975-17. 771 1.00 0.00 O ATOM 5099 C5'URI 10 18.385 2.420-17. 586 1.00 0.00 C ATOM 5100 C4'URI 10 18.508 3.321-16. 361 1.00 0.00 C ATOM 5101 04'URI 10 18.259 2. 594-15.147 1.00 0.00 0 ATOM 5102 CAURI 10 19.452 2.561-14. 345 1.00 0.00 C ATOM 5103 N1 URI 10 19.644 1.235-13. 717 1.00 0.00 N ATOM 5104 C6 URI 10 18.909 0.151-14. 118 1.00 0.00 C ATOM 5105 C2 URI 10 20.593 1.131-12. 714 1.00 0.00 C ATOM 5106 02 URI 10 21. 261 2.094-12. 338 1.00 0.00 0 ATOM 5107 N3 URI 10 20.749-0. 122-12.152 1.00 0.00 N ATOM 5108 C4 URI 10 20.050-1. 266-12.499 1.00 0.00 C ATOM 5109 04 URI 10 20.274-2. 332-11.930 1.00 0.00 O ATOM 5110 C5 URI 10 19.081-1. 067-13.552 1. 00 0.00 C ATOM 5111 C2'URI 10 20.589 2.891-15. 299 1.00 0.00 C ATOM 5112 02'URI 10 21.705 3.472-14. 614 1.00 0.00 0 ATOM 5113 C3'URI 10 19.919 3.886-16. 226 1.00 0.00 C ATOM 5114 03'URI 10 19.834 5.150-15. 555 1.00 0.00 0 ATOM 5115 1H5'URI 10 18.698 2.977-18. 470 1.00 0.00 H ATOM 5116 2H5'URI 10 19.037 1.555-17. 462 1.00 0.00 H ATOM 5117 H4'URI 10 17.794 4.139-16. 440 1. 00 0.00 H ATOM 5118 H1'URI 10 19.394 3.327-13. 570 1.00 0.00 H ATOM 5119 H6 URI 10 18.168 0.271-14. 908 1.00 0.00 H ATOM 5120 H3 URI 10 21.439-0. 213-11.420 1.00 0.00 H ATOM 5121 H5 URI 10 18.479-1. 908-13.895 1.00 0.00 H ATOM 5122 H2'URI 10 20.886 1.998-15. 857 1.00 0.00 H ATOM 5123 H02'URI 10 21.926 2.891-13. 882 1.00 0.00 H ATOM 5124 H3'URI 10 20.426 3.961-17. 189 1.00 0.00 H ATOM 5125 P GUA 11 19.305 6.461-16. 331 1.00 0.00 P ATOM 5126 O1P GUA 11 20.079 6.599-17. 587 1.00 0.00 0 ATOM 5127 02P GUA 11 19.260 7.582-15. 367 1.00 0.00 0 ATOM 5128 05'GUA 11 17.789 6.061-16. 708 1.00 0.00 0 ATOM 5129 C5'GUA 11 17.339 6.091-18. 067 1.00 0.00 C ATOM 5130 C4'GUA 11 15.851 6.413-18. 160 1.00 0.00 C ATOM 5131 04'GUA 11 15.043 5.400-17. 540 1.00 0.00 0 ATOM 5132 C1'GUA 11 14.041 6.027-16. 716 1.00 0.00 C ATOM 5133 N9 GUA 11 14.360 5.871-15. 286 1. 00 0.00 N ATOM 5134 C4 GUA 11 13.686 6.436-14. 230 1.00 0.00 C ATOM 5135 N3 GUA 11 12.614 7.252-14. 323 1.00 0.00 N ATOM 5136 C2 GUA 11 12.174 7.644-13. 126 1.00 0.00 C ATOM 5137 N2 GUA 11 11.124 8.457-13. 038 1.00 0. 00 N ATOM 5138 N1 GUA 11 12.751 7.257-11. 933 1.00 0.00 N ATOM 5139 C6 GUA 11 13.852 6.420-11. 812 1.00 0.00 C ATOM 5140 06 GUA 11 14.289 6.132-10. 701 1.00 0.00 0 ATOM 5141 C5 GUA 11 14.328 5.999-13. 081 1.00 0.00 C ATOM 5142 N7 GUA 11 15.401 5.165-13. 406 1.00 0.00 N ATOM 5143 C8 GUA 11 15.340 5.151-14. 694 1. 00 0.00 C ATOM 5144 C2'GUA 11 14.047 7.495-17. 121 1.00 0.00 C ATOM 5145 02'GUA 11 13.243 7.727-18. 284 1. 00 0.00 O ATOM 5146 C3'GUA 11 15.519 7.690-17. 407 1.00 0.00 C ATOM 5147 03'GUA 11 15. 686 8. 802-18. 290 1.00 0.00 0 ATOM 5148 1H5'GUA 11 17. 522 5.119-18. 526 1.00 0.00 H ATOM 5149 2H5'GUA 11 17.901 6.852-18. 610 1. 00 0.00 H ATOM 5150 H4'GUA 11 15.561 6.517-19. 204 1. 00 0. 00 H

ATOM 5151 Hl'GUA 11 13.063 5.588-16. 922 1.00 0.00 H ATOM 5152 1H2 GUA 11 10.789 8.754-12. 133 1.00 0. 00 H ATOM 5153 2H2 GUA 11 10.662 8.777-13. 877 1.00 0.00 H ATOM 5154 H1 GUA 11 12.357 7.597-11. 068 1.00 0.00 H ATOM 5155 H8 GUA 11 16.053 4.585-15. 288 1.00 0.00 H ATOM 5156 H2'GUA 11 13. 730 8.125-16. 284 1.00 0.00 H ATOM 5157 H02'GUA 11 13.431 8.618-18. 587 1.00 0.00 H ATOM 5158 H3'GUA 11 16.102 7.789-16. 490 1.00 0.00 H ATOM 5159 P CYT 12 16.543 10.081-17. 822 1.00 0.00 P ATOM 5160 O1P CYT 12 16.691 10.990-18. 980 1.00 0.00 0 ATOM 5161 02P CYT 12 17.745 9.598-17. 104 1.00 0.00 0 ATOM 5162 05'CYT 12 15.563 10.776-16. 753 1.00 0.00 0 ATOM 5163 C5'CYT 12 14.365 11.425-17. 189 1.00 0.00 C ATOM 5164 C4'CYT 12 13. 502 11.872-16. 014 1.00 0.00 C ATOM 5165 04'CYT 12 13.064 10.766-15. 219 1.00 0.00 0 ATOM 5166 C1'CYT 12 13.059 11.152-13. 829 1. 00 0. 00 C ATOM 5167 N1 CYT 12 14. 013 10.341-13. 038 1.00 0.00 N ATOM 5168 C6 CYT 12 14.931 9.534-13. 650 1.00 0.00 C ATOM 5169 C2 CYT 12 13.929 10.419-11. 653 1.00 0.00 C ATOM 5170 02 CYT 12 13.108 11.165-11. 123 1.00 0.00 0 ATOM 5171 N3 CYT 12 14.782 9.663-10. 912 1.00 0.00 N ATOM 5172 C4 CYT 12 15.684 8.866-11. 499 1.00 0.00 C ATOM 5173 N4 CYT 12 16.493 8.127-10. 741 1.00 0.00 N ATOM 5174 C5 CYT 12 15.779 8.786-12. 923 1.00 0.00 C ATOM 5175 C2'CYT 12 13.437 12. 632-13.802 1.00 0.00 C ATOM 5176 02'CYT 12 12.279 13.471-13. 868 1.00 0.00 0 ATOM 5177 C3'CYT 12 14.283 12.745-15. 052 1.00 0.00 C ATOM 5178 03'CYT 12 14.245 14.094-15. 525 1.00 0.00 0 ATOM 5179 1H5'CYT 12 13.792 10.736-17. 809 1.00 0.00 H ATOM 5180 2H5'CYT 12 14.633 12.299-17. 784 1.00 0.00 H ATOM 5181 H4'CYT 12 12.634 12.416-16. 381 1.00 0.00 H ATOM 5182 H1'CYT 12 12. 054 11.029-13. 424 1.00 0.00 H ATOM 5183 H6 CYT 12 14.976 9.494-14. 738 1. 00 0.00 H ATOM 5184 1H4 CYT 12 17.170 7.515-11. 173 1.00 0.00 H ATOM 5185 2H4 CYT 12 16.426 8.176-9. 734 1.00 0.00 H ATOM 5186 H5 CYT 12 1. 6. 515 8.142-13. 403 1.00 0.00 H ATOM 5187 H2'CYT 12 14.034 12.854-12. 915 1.00 0.00 H ATOM 5188 H02'CYT 12 11.730 13.142-14. 583 1. 00 0.00 H ATOM 5189 H3'CYT 12 15.299 12. 380-14.892 1.00 0.00 H ATOM 5190 P URI 13 15.495 15.079-15. 279 1.00 0.00 P ATOM 5191 01P URI 13 16.741 14.292-15. 419 1.00 0.00 0 ATOM 5192 02P URI 13 15.294 16.295-16. 097 1.00 0.00 0 ATOM 5193 05'URI 13 15.322 15.475-13. 730 1. 00 0.00 O ATOM 5194 C5'URI 13 14. 279 16.364-13. 319 1.00 0.00 C ATOM 5195 C4'URI 13 14.141 16.401-11. 801 1.00 0.00 C ATOM 5196 04'URI 13 13.789 15. 120-11. 269 1.00 0.00 0 ATOM 5197 C1'URI 13 14. 492 14.908-10. 029 1.00 0.00 C ATOM 5198 N1 URI 13 15.423 13.759-10. 123 1.00 0.00 N ATOM 5199 C6 URI 13 15.893 13.319-11. 334 1.00 0.00 C ATOM 5200 C2 URI 13 15.792 13.143-8. 940 1.00 0.00 C ATOM 5201 02 URI 13 15.385 13.525-7. 845 1.00 0.00 0 ATOM 5202 N3 URI 13 16.650 12.068-9. 058 1.00 0.00 N ATOM 5203 C4 URI 13 17.167 11.557-10. 235 1.00 0. 00 C ATOM 5204 04 URI 13 17.916 10.584-10. 220 1.00 0.00 O ATOM 5205 C5 URI 13 16.733 12.260-11. 421 1.00 0.00 C ATOM 5206 C2'URI 13 15.243 16.205-9. 739 1.00 0. 00 C ATOM 5207 02'URI 13 14.458 17.101-8. 942 1.00 0.00 O ATOM 5208 C3'URI 13 15.460 16. 745-11.137 1.00 0.00 C ATOM 5209 03'URI 13 15.586 18. 168-11.071 1.00 0.00 O ATOM 5210 1H5'URI 13 13.335 16. 033-13.754 1.00 0. 00 H

ATOM 5211 2H5'URI 13 14.505 17.367-13. 681 1.00 0.00 H ATOM 5212 H4'URI 13 13.384 17.131-11. 517 1.00 0.00 H ATOM 5213 H1'URI 13 13.769 14.724-9. 233 1.00 0.00 H ATOM 5214 H6 URI 13 15.586 13.830-12. 247 1.00 0.00 H ATOM 5215 H3 URI 13 16.930 11.614-8. 201 1.00 0.00 H ATOM 5216 H5 URI 13 17.089 11.935-12. 399 1.00 0.00 H ATOM 5217 H2'URI 13 16.201 15.989-9. 260 1.00 0.00 H ATOM 5218 H02'URI 13 14.890 17. 958-8. 968 1.00 0.00 H ATOM 5219 H3'URI 13 16.308 16. 268-11. 632 1. 00 0.00 H ATOM 5220 P CYT 14 17.040 18.860-11. 096 1.00 0.00 P ATOM 5221 01P CYT 14 16.856 20.318-11. 272 1.00 0.00 0 ATOM 5222 02P CYT 14 17.897 18.105-12. 039 1.00 0.00 0 ATOM 5223 05'CYT 14 17.581 18.592-9. 603 1. 00 0.00 O ATOM 5224 C5'CYT 14 17.229 19.469-8. 528 1.00 0.00 C ATOM 5225 C4'CYT 14 17.834 19. 004-7.207 1.00 0.00 C ATOM 5226 04'CYT 14 17.368 17. 702-6.844 1.00 0.00 O ATOM 5227 C1'CYT 14 18.441 16.954-6. 242 1.00 0.00 C ATOM 5228 N1 CYT 14 18.756 15.736-7. 017 1.00 0.00 N ATOM 5229 C6 CYT 14 18.550 15. 683-8.365 1.00 0.00 C ATOM 5230 C2 CYT 14 19.285 14.657-6. 322 1.00 0.00 C ATOM 5231 02 CYT 14 19.461 14.729-5. 107 1.00 0.00 0 ATOM 5232 N3 CYT 14 19.600 13.533-7. 018 1.00 0.00 N ATOM 5233 C4 CYT 14 19.406 13.467-8. 339 1. 00 0.00 C ATOM 5234 N4 CYT 14 19.740 12. 356-8.991 1.00 0.00 N ATOM 5235 C5 CYT 14 18.858 14.574-9. 060 1.00 0.00 C ATOM 5236 C2'CYT 14 19.647 17.890-6. 191 1. 00 0.00 C ATOM 5237 02'CYT 14 19.742 18.557-4. 926 1.00 0.00 O ATOM 5238 C3'CYT 14 19.341 18. 861-7.315 1.00 0.00 C ATOM 5239 03'CYT 14 19.946 20.120-7. 006 1.00 0.00 O ATOM 5240 1H5'CYT 14 16. 143 19.498-8. 432 1.00 0.00 H ATOM 5241 2H5'CYT 14 17.593 20.471-8. 754 1.00 0.00 H ATOM 5242 H4'CYT 14 17.586 19.711-6. 417 1.00 0.00 H ATOM 5243 H1'CYT 14 18.159 16.674-5. 227 1.00 0.00 H ATOM 5244 H6 CYT 14 18. 133 16.546-8. 883 1.00 0.00 H ATOM 5245 1H4 CYT 14 19.606 12.296-9. 990 1.00 0.00 H ATOM 5246 2H4 CYT 14 20.134 11.574-8. 486 1.00 0.00 H ATOM 5247 H5 CYT 14 18.699 14.523-10. 136 1.00 0.00 H ATOM 5248 H2'CYT 14 20.563 17.334-6. 411 1.00 0.00 H ATOM 5249 H02'CYT 14 18.912 19.016-4. 783 1.00 0.00 H ATOM 5250 H3'CYT 14 19.650 18.472-8. 286 1.00 0.00 H ATOM 5251 P URI 15 21.367 20.522-7. 649 1.00 0.00 P ATOM 5252 O1P URI 15 21.893 21.694-6. 914 1. 00 0.00 O ATOM 5253 02P URI 15 21.208 20.584-9. 119 1.00 0.00 O ATOM 5254 05'URI 15 22. 287 19.247-7. 297 1.00 0.00 O ATOM 5255 C5'URI 15 22.850 19. 085-5. 991 1.00 0.00 C ATOM 5256 C4'URI 15 23.496 17.711-5. 826 1.00 0.00 C ATOM 5257 04'URI 15 22.539 16.652-5. 987 1.00 0.00 0 ATOM 5258 C1'URI 15 23.094 15.627-6. 834 1.00 0.00 C ATOM 5259 N1 URI 15 22.451 15.626-8. 168 1. 00 0.00 N ATOM 5260 C6 URI 15 21.995 16.789-8. 726 1.00 0. 00 C ATOM 5261 C2 URI 15 22.345 14.416-8. 833 1.00 0.00 C ATOM 5262 02 URI 15 22.744 13.360-8. 347 1.00 0. 00 0 ATOM 5263 N3 URI 15 21.756 14.462-10. 084 1.00 0.00 N ATOM 5264 C4 URI 15 21. 272 15.593-10. 718 1.00 0.00 C ATOM 5265 04 URI 15 20.765 15.515-11. 834 1.00 0.00 O ATOM 5266 C5 URI 15 21.424 16.808-9. 951 1.00 0.00 C ATOM 5267 C2'URI 15 24.580 15.948-6. 942 1.00 0.00 C ATOM 5268 02'URI 15 25.317 15.405-5. 839 1.00 0.00 0 ATOM 5269 C3'URI 15 24.544 17.461-6. 900 1.00 0. 00 C ATOM 5270 03'URI 15 25.807 17.943-6. 432 1.00 0. 00 O

ATOM 5271 1H5'URI 15 22.063 19.199-5. 245 1.00 0.00 H ATOM 5272 2H5'URI 15 23.606 19.854-5. 832 1.00 0.00 H ATOM 5273 H4'URI 15 23.954 17.636-4. 842 1.00 0.00 H ATOM 5274 H1'URI 15 22.963 14.653-6. 362 1.00 0.00 H ATOM 5275 H6 URI 15 22.088 17.721-8. 169 1.00 0. 00 H ATOM 5276 H3 URI 15 21.674 13.588-10. 582 1.00 0.00 H ATOM 5277 H5 URI 15 21.078 17.753-10. 365 1.00 0.00 H ATOM 5278 H2'URI 15 24.982 15.597-7. 899 1.00 0.00 H ATOM 5279 H02'URI 15 25.187 14.453-5. 851 1.00 0.00 H ATOM 5280 H3'URI 15 24.257 17.889-7. 864 1.00 0.00 H ATOM 5281 P URI 16 27.089 17.958-7. 406 1.00 0.00 P ATOM 5282 O1P URI 16 28.147 18.772-6. 766 1.00 0.00 0 ATOM 5283 02P URI 16 26.630 18.288-8. 775 1.00 0.00 0 ATOM 5284 05'URI 16 27.559 16.419-7. 391 1.00 0.00 0 ATOM 5285 C5'URI 16 28.742 16.012-8. 084 1.00 0.00 C ATOM 5286 C4'URI 16 29.765 15.404-7. 136 1.00 0.00 C ATOM 5287 04'URI 16 30.012 16. 264-6. 014 1.00 0.00 0 ATOM 5288 Cl'URI 16 29.772 15.550-4. 798 1.00 0.00 C ATOM 5289 N1 URI 16 29.212 16.442-3. 758 1.00 0.00 N ATOM 5290 C6 URI 16 27.986 17.033-3. 921 1.00 0.00 C ATOM 5291 C2 URI 16 29.971 16.657-2. 620 1.00 0.00 C ATOM 5292 02 URI 16 31.074 16.136-2. 457 1.00 0.00 0 ATOM 5293 N3 URI 16 29.418 17.497-1. 671 1.00 0.00 N ATOM 5294 C4 URI 16 28.191 18.131-1. 756 1.00 0.00 C ATOM 5295 04 URI 16 27.798 18.859-0. 847 1.00 0.00 O ATOM 5296 C5 URI 16 27.466 17.851-2. 975 1.00 0.00 C ATOM 5297 C2'URI 16 28.793 14.447-5. 166 1.00 0.00 C ATOM 5298 02'URI 16 28.886 13.336-4. 268 1.00 0.00 O ATOM 5299 C3'URI 16 29.256 14.080-6. 565 1.00 0.00 C ATOM 5300 03'URI 16 30.365 13.181-6. 464 1.00 0.00 O ATOM 5301 1H5'URI 16 29.179 16.869-8. 582 1.00 0.00 H ATOM 5302 2H5'URI 16 28.480 15.274-8. 831 1.00 0.00 H ATOM 5303 H4'URI 16 30.699 15.235-7. 671 1.00 0.00 H ATOM 5304 H1'URI 16 30.703 15.108-4. 442 1.00 0.00 H ATOM 5305 H6 URI 16 27.417 16.842-4. 830 1.00 0.00 H ATOM 5306 H3 URI 16 29.961 17.663-0. 836 1.00 0.00 H ATOM 5307 H5 URI 16 26.487 18.303-3. 135 1.00 0.00 H ATOM 5308 H2'URI 16 27.774 14.841-5. 203 1.00 0.00 H ATOM 5309 H02'URI 16 28.354 12.627-4. 636 1.00 0.00 H ATOM 5310 H3'URI 16 28.445 13.664-7. 165 1.00 0.00 H ATOM 5311 P CYT 17 31.002 12.522-7. 791 1.00 0.00 P ATOM 5312 O1P CYT 17 31.479 13.612-8. 671 1.00 0.00 0 ATOM 5313 02P CYT 17 31.934 11.450-7. 374 1.00 0.00 O ATOM 5314 05'CYT 17 29.721 11.836-8. 486 1.00 0.00 0 ATOM 5315 C5'CYT 17 29.084 10.715-7. 870 1.00 0.00 C ATOM 5316 C4'CYT 17 27.803 10.313-8. 592 1.00 0.00 C ATOM 5317 04'CYT 17 26.872 11.405-8. 646 1.00 0.00 0 ATOM 5318 C1'CYT 17 26.402 11.542-9. 984 1.00 0.00 C ATOM 5319 N1 CYT 17 25.992 12.928-10. 275 1.00 0.00 N ATOM 5320 C6 CYT 17 26.821 13.967-10. 000 1.00 0.00 C ATOM 5321 C2 CYT 17 24.730 13.130-10. 819 1.00 0.00 C ATOM 5322 02 CYT 17 23.996 12.172-11. 058 1.00 0.00 O ATOM 5323 N3 CYT 17 24.335 14.408-11. 071 1.00 0.00 N ATOM 5324 C4 CYT 17 25.140 15. 442-10. 802 1.00 0.00 C ATOM 5325 N4 CYT 17 24.719 16.681-11. 054 1.00 0.00 N ATOM 5326 C5 CYT 17 26.440 15.233-10. 243 1.00 0.00 C ATOM 5327 C2'CYT 17 27.573 11.106-10. 842 1.00 0.00 C ATOM 5328 02'CYT 17 27.155 10. 722-12.157 1.00 0.00 0 ATOM 5329 C3'CYT 17 28.090 9. 919-10. 042 1.00 0.00 C ATOM 5330 03'CYT 17 27.286 8.777-10. 365 1.00 0.00 O

ATOM 5331 1H5'CYT 17 28.843 10.965-6. 842 1.00 0.00 H ATOM 5332 2H5'CYT 17 29.771 9.873-7. 879 1.00 0.00 H ATOM 5333 H4'CYT 17 27.343 9.475-8. 073 1.00 0.00 H ATOM 5334 H1'CYT 17 25.564 10.873-10. 144 1.00 0.00 H ATOM 5335 H6 CYT 17 27.807 13.768-9. 585 1.00 0.00 H ATOM 5336 1H4 CYT 17 25.317 17.469-10. 850 1.00 0.00 H ATOM 5337 2H4 CYT 17 23.802 16.832-11. 449 1.00 0.00 H ATOM 5338 H5 CYT 17 27.096 16.069-10. 015 1.00 0.00 H ATOM 5339 H2'CYT 17 28.331 11.894-10. 879 1.00 0.00 H ATOM 5340 H02'CYT 17 26.499 10.028-12. 055 1.00 0.00 H ATOM 5341 H3'CYT 17 29.151 9.740-10. 209 1.00 0.00 H ATOM 5342 P GUA 18 27.920 7.295-10. 364 1.00 0.00 P ATOM 5343 01P GUA 18 26.878 6.347-10. 821 1.00 0.00 0 ATOM 5344 02P GUA 18 29.224 7.347-11. 062 1.00 0.00 O ATOM 5345 05'GUA 18 28.196 7.025-8. 800 1.00 0.00 0 ATOM 5346 C5'GUA 18 27.112 6.816-7. 889 1.00 0.00 C ATOM 5347 C4'GUA 18 27.590 6.840-6. 439 1.00 0.00 C ATOM 5348 04'GUA 18 28.194 8.095-6. 110 1.00 0.00 0 ATOM 5349 C1'GUA 18 27.801 8.492-4. 784 1.00 0.00 C ATOM 5350 N9 GUA 18 27.012 9.741-4. 806 1.00 0.00 N ATOM 5351 C4 GUA 18 26.044 10.094-5. 722 1.00 0.00 C ATOM 5352 N3 GUA 18 25.635 9.350-6. 775 1. 00 0.00 N ATOM 5353 C2 GUA 18 24. 681 9.960-7. 485 1.00 0.00 C ATOM 5354 N2 GUA 18 24.164 9.362-8. 559 1.00 0.00 N ATOM 5355 N1 GUA 18 24.173 11.205-7. 174 1.00 0.00 N ATOM 5356 C6 GUA 18 24.574 11.986-6. 099 1. 00 0.00 C ATOM 5357 06 GUA 18 24.050 13.078-5. 901 1.00 0.00 O ATOM 5358 C5 GUA 18 25.588 11.347-5. 340 1. 00 0.00 C ATOM 5359 N7 GUA 18 26.258 11.787-4. 195 1. 00 0.00 N ATOM 5360 C8 GUA 18 27.055 10.800-3. 961 1.00 0.00 C ATOM 5361 C2'GUA 18 26.985 7.334-4. 213 1.00 0.00 C ATOM 5362 02'GUA 18 27.811 6.421-3. 481 1. 00 0.00 0 ATOM 5363 C3'GUA 18 26.427 6.696-5. 472 1.00 0.00 C ATOM 5364 03'GUA 18 26.209 5.302-5. 219 1. 00 0.00 0 ATOM 5365 1H5'GUA 18 26.653 5.850-8. 097 1.00 0.00 H ATOM 5366 2H5'GUA 18 26.370 7.602-8. 032 1.00 0.00 H ATOM 5367 H4'GUA 18 28.308 6.038-6. 274 1.00 0.00 H ATOM 5368 Hl'GUA 18 28.695 8.640-4. 175 1.00 0.00 H ATOM 5369 1H2 GUA 18 23. 443 9.823-9. 095 1.00 0.00 H ATOM 5370 2H2 GUA 18 24.494 8.449-8. 836 1.00 0.00 H ATOM 5371 H1 GUA 18 23.454 11.600-7. 764 1.00 0.00 H ATOM 5372 H8 GUA 18 27.740 10.818-3. 113 1.00 0.00 H ATOM 5373 H2'GUA 18 26.172 7.716-3. 589 1.00 0.00 H ATOM 5374 H02'GUA 18 27.301 5.618-3. 350 1.00 0.00 H ATOM 5375 H3'GUA 18 25.531 7.206-5. 827 1.00 0.00 H ATOM 5376 P GUA 19 24.717 4.692-5. 185 1.00 0.00 P ATOM 5377 01P GUA 19 24.808 3. 265-4. 803 1.00 0.00 0 ATOM 5378 02P GUA 19 24.032 5.077-6. 440 1.00 0.00 0 ATOM 5379 05'GUA 19 24.030 5.498-3. 970 1.00 0.00 0 ATOM 5380 C5'GUA 19 24.397 5.231-2. 612 1. 00 0.00 C ATOM 5381 C4'GUA 19 24.080 6.415-1. 701 1. 00 0.00 C ATOM 5382 04'GUA 19 24.676 7.630-2. 188 1.00 0.00 O ATOM 5383 C1'GUA 19 23.687 8.678-2. 195 1. 00 0.00 C ATOM 5384 N9 GUA 19 23.194 8.943-3. 561 1.00 0.00 N ATOM 5385 C4 GUA 19 22.475 10.041-3. 978 1. 00 0.00 C ATOM 5386 N3 GUA 19 22.115 11.095-3. 210 1. 00 0.00 N ATOM 5387 C2 GUA 19 21.419 12.006-3. 897 1.00 0.00 C ATOM 5388 N2 GUA 19 20. 985 13.109-3. 288 1.00 0.00 N ATOM 5389 N1 GUA 19 21.105 11.880-5. 236 1.00 0.00 N ATOM 5390 C6 GUA 19 21.464 10.810-6. 043 1.00 0.00 C

ATOM 5391 06 GUA 19 21.138 10.793-7. 227 1.00 0.00 O ATOM 5392 C5 GUA 19 22.203 9.837-5. 322 1.00 0.00 C ATOM 5393 N7 GUA 19 22.744 8.625-5. 756 1.00 0.00 N ATOM 5394 C8 GUA 19 23.294 8.182-4. 677 1.00 0.00 C ATOM 5395 C2'GUA 19 22.564 8.170-1. 308 1.00 0.00 C ATOM 5396 02'GUA 19 22. 844 8.391 0.080 1.00 0. 00 0 ATOM 5397 C3'GUA 19 22.584 6.697-1. 659 1.00 0.00 C ATOM 5398 03'GUA 19 22. 001 5.958-0. 583 1.00 0.00 0 ATOM 5399 1H5'GUA 19 25.465 5.022-2. 565 1.00 0.00 H ATOM 5400 2H5'GUA 19 23.848 4.356-2. 261 1.00 0. 00 H ATOM 5401 H4'GUA 19 24.443 6.213-0. 695 1.00 0.00 H ATOM 5402 H1'GUA 19 24.111 9.589-1. 770 1.00 0.00 H ATOM 5403 1H2 GUA 19 21.183 13.256-2. 309 1.00 0.00 H ATOM 5404 2H2 GUA 19 20.458 13.798-3. 806 1.00 0.00 H ATOM 5405 H1 GUA 19 20.571 12.611-5. 684 1.00 0.00 H ATOM 5406 H8 GUA 19 23.817 7.228-4. 663 1.00 0.00 H ATOM 5407 H2'GUA 19 21.613 8.623-1. 599 1.00 0.00 H ATOM 5408 H02'GUA 19 23.714 8.026 0.257 1.00 0.00 H ATOM 5409 H3'GUA 19 22.101 6.500-2. 618 1.00 0.00 H ATOM 5410 P ADE 20 20.428 5.612-0. 596 1.00 0.00 P ATOM 5411 01P ADE 20 20.110 4.942-1. 877 1.00 0.00 0 ATOM 5412 02P ADE 20 20.088 4.953 0.685 1.00 0.00 0 ATOM 5413 05'ADE 20 19.750 7.072-0. 610 1.00 0.00 0 ATOM 5414 C5'ADE 20 19.742 7.883 0.569 1.00 0.00 C ATOM 5415 C4'ADE 20 19.031 9.212 0.330 1.00 0.00 C ATOM 5416 04'ADE 20 19.699 10.002-0. 660 1.00 0.00 0 ATOM 5417 C1'ADE 20 18.723 10.617-1. 524 1.00 0.00 C ATOM 5418 N9 ADE 20 18.812 10.081-2. 897 1.00 0.00 N ATOM 5419 C4 ADE 20 18.285 10.647-4. 037 1.00 0.00 C ATOM 5420 N3 ADE 20 17.575 11.790-4. 108 1.00 0.00 N ATOM 5421 C2 ADE 20 17.213 12.058-5. 359 1.00 0.00 C ATOM 5422 N1 ADE 20 17.483 11.336-6. 447 1.00 0.00 N ATOM 5423 C6 ADE 20 18.195 10.199-6. 352 1.00 0.00 C ATOM 5424 N6 ADE 20 18.467 9.503-7. 455 1.00 0.00 N ATOM 5425 C5 ADE 20 18.628 9.816-5. 079 1.00 0.00 C ATOM 5426 N7 ADE 20 19.368 8.722-4. 620 1.00 0.00 N ATOM 5427 C8 ADE 20 19.423 8.959-3. 353 1.00 0.00 C ATOM 5428 C2'ADE 20 17. 362 10.316-0. 903 1.00 0.00 C ATOM 5429 02'ADE 20 16.977 11.328 0.036 1.00 0.00 0 ATOM 5430 C3'ADE 20 17.635 8.992-0. 221 1.00 0.00 C ATOM 5431 03'ADE 20 16.729 8.839 0.874 1.00 0.00 0 ATOM 5432 1H5'ADE 20 20.770 8.079 0.875 1.00 0.00 H ATOM 5433 2H5'ADE 20 19.230 7.344 1.366 1.00 0.00 H ATOM 5434 H4'ADE 20 18.975 9.772 1.262 1.00 0.00 H ATOM 5435 H1'ADE 20 18.883 11.696-1. 543 1.00 0.00 H ATOM 5436 H2 ADE 20 16.631 12.967-5. 513 1.00 0.00 H ATOM 5437 1H6 ADE 20 19.010 8.653-7. 395 1.00 0.00 H ATOM 5438 2H6 ADE 20 18.134 9.827-8. 352 1.00 0.00 H ATOM 5439 H8 ADE 20 19.937 8.280-2. 674 1.00 0.00 H ATOM 5440 H2'ADE 20 16.607 10.195-1. 685 1.00 0.00 H ATOM 5441 H02'ADE 20 17.666 11.377 0.702 1.00 0.00 H ATOM 5442 H3'ADE 20 17.596 8.156-0. 921 1.00 0.00 H ATOM 5443 P GUA 21 15.341 8. 051 0.676 1.00 0.00 P ATOM 5444 O1P GUA 21 14.651 7.993 1.985 1. 00 0.00 O ATOM 5445 02P GUA 21 15.618 6.801-0. 068 1.00 0.00 0.

ATOM 5446 05'GUA 21 14.515 9.039-0. 289 1.00 0.00 O ATOM 5447 C5'GUA 21 13.874 10.203 0.241 1.00 0.00 C ATOM 5448 C4'GUA 21 13.087 10.948-0. 832 1.00 0.00 C ATOM 5449 04'GUA 21 13.938 11.459-1. 862 1.00 0.00 O ATOM 5450 C1'GUA 21 13.263 11.357-3. 132 1.00 0.00 C

ATOM 5451 N9 GUA 21 14.006 10.483-4. 063 1.00 0.00 N ATOM 5452 C4 GUA 21 13.970 10.532-5. 439 1.00 0.00 C ATOM 5453 N3 GUA 21 13.216 11. 374-6.182 1.00 0.00 N ATOM 5454 C2 GUA 21 13.393 11.187-7. 493 1.00 0.00 C ATOM 5455 N2 GUA 21 12.714 11. 927-8.368 1.00 0.00 N ATOM 5456 N1 GUA 21 14. 250 10.243-8. 024 1.00 0.00 N ATOM 5457 C6 GUA 21 15.034 9.369-7. 283 1.00 0.00 C ATOM 5458 06 GUA 21 15.773 8.570-7. 854 1. 00 0.00 O ATOM 5459 C5 GUA 21 14.850 9.559-5. 887 1.00 0.00 C ATOM 5460 N7 GUA 21 15.439 8.894-4. 807 1.00 0.00 N ATOM 5461 C8 GUA 21 14.893 9. 491-3. 800 1.00 0.00 C ATOM 5462 C2'GUA 21 11.873 10. 794-2.833 1.00 0.00 C ATOM 5463 02'GUA 21 10.914 11.840-2. 634 1.00 0.00 0 ATOM 5464 C3'GUA 21 12.129 10.021-1. 554 1.00 0.00 C ATOM 5465 03'GUA 21 10.913 9.941-0. 804 1.00 0.00 O ATOM 5466 1H5'GUA 21 14.630 10.870 0.656 1.00 0.00 H ATOM 5467 2H5'GUA 21 13.192 9.901 1.036 1.00 0.00 H ATOM 5468 H4'GUA 21 12.533 11.770-0. 380 1.00 0.00 H ATOM 5469 Hl'GUA 21 13.165 12.351-3. 570 1.00 0.00 H ATOM 5470 1H2 GUA 21 12.067 12.630-8. 040 1.00 0.00 H ATOM 5471 2H2 GUA 21 12.843 11.784-9. 360 1.00 0.00 H ATOM 5472 H1 GUA 21 14.329 10.166-9. 028 1.00 0.00 H ATOM 5473 H8 GUA 21 15.129 9.202-2. 777 1.00 0.00 H ATOM 5474 H2'GUA 21 11.558 10.117-3. 630 1.00 0.00 H ATOM 5475 H02'GUA 21 10.616 12.122-3. 502 1.00 0.00 H ATOM 5476 H3'GUA 21 12.572 9.043-1. 750 1.00 0.00 H ATOM 5477 P ADE 22 9.930 8.675-0. 971 1.00 0.00 P ATOM 5478 O1P ADE 22 8.948 8.703 0.136 1.00 0.00 0 ATOM 5479 02P ADE 22 10.757 7.469-1. 193 1.00 0.00 O ATOM 5480 05'ADE 22 9.155 9.014-2. 340 1.00 0.00 O ATOM 5481 C5'ADE 22 8.237 10.109-2. 400 1.00 0.00 C ATOM 5482 C4'ADE 22 7.996 10.564-3. 836 1.00 0.00 C ATOM 5483 04'ADE 22 9. 222 10. 895-4.498 1.00 0.00 O ATOM 5484 C1'ADE 22 9.162 10.448-5. 867 1.00 0.00 C ATOM 5485 N9 ADE 22 10.160 9.394-6. 137 1.00 0.00 N ATOM 5486 C4 ADE 22 10.772 9.138-7. 342 1.00 0.00 C ATOM 5487 N3 ADE 22 10.567 9.801-8. 496 1.00 0.00 N ATOM 5488 C2 ADE 22 11.313 9.307-9. 476 1.00 0.00 C ATOM 5489 N1 ADE 22 12. 175 8.290-9. 401 1.00 0.00 N ATOM 5490 C6 ADE 22 12. 362 7.643-8. 237 1.00 0.00 C ATOM 5491 N6 ADE 22 13.229 6.631-8. 183 1.00 0.00 N ATOM 5492 C5 ADE 22 11.625 8.079-7. 132 1.00 0.00 C ATOM 5493 N7 ADE 22 11.567 7.651-5. 802 1.00 0.00 N ATOM 5494 C8 ADE 22 10.697 8.466-5. 305 1.00 0.00 C ATOM 5495 C2'ADE 22 7.743 9.929-6. 077 1.00 0.00 C ATOM 5496 02'ADE 22 6.868 10.973-6. 518 1.00 0.00 O ATOM 5497 C3'ADE 22 7.391 9.457-4. 681 1.00 0.00 C ATOM 5498 03'ADE 22 5.966 9. 484-4. 529 1.00 0.00 O ATOM 5499 1H5'ADE 22 8.642 10.944-1. 827 1.00 0.00 H ATOM 5500 2H5'ADE 22 7.289 9.802-1. 960 1.00 0.00 H ATOM 5501 H4'ADE 22 7.338 11.432-3. 842 1.00 0.00 H ATOM 5502 H1'ADE 22 9. 338 11.295-6. 531 1.00 0. 00 H ATOM 5503 H2 ADE 22 11.209 9.784-10. 451 1.00 0.00 H ATOM 5504 1H6 ADE 22 13.379 6.140-7. 313 1.00 0.00 H ATOM 5505 2H6 ADE 22 13.737 6.357-9. 012 1.00 0. 00 H ATOM 5506 H8 ADE 22 10.401 8.406-4. 258 1.00 0.00 H ATOM 5507, H2' ADE 22 7.744 9.090-6. 777 1.00 0.00 H ATOM 5508 H02'ADE 22 6.906 10.991-7. 477 1. 00 0.00 H ATOM 5509 H3'ADE 22 7.823 8.481-4. 456 1.00 0.00 H ATOM 5510 P CYT 23 5.052 8.294-5. 121 1.00 0. 00 P

ATOM 5511 01P CYT 23 3.662 8.504-4. 657 1.00 0. 00 O ATOM 5512 02P CYT 23 5.732 7.007-4. 850 1.00 0. 00 0 ATOM 5513 05'CYT 23 5.102 8.563-6. 709 1.00 0.00 0 ATOM 5514 C5'CYT 23 4.518 9.746-7. 265 1.00 0.00 C ATOM 5515 C4'CYT 23 4.947 9.963-8. 715 1.00 0.00 C ATOM 5516 04'CYT 23 6.369 9.983-8. 850 1.00 0.00 0 ATOM 5517 C1'CYT 23 6.738 9.408-10. 119 1.00 0.00 C ATOM 5518 N1 CYT 23 7.662 8.264-9. 947 1.00 0.00 N ATOM 5519 C6 CYT 23 7.539 7.405-8. 892 1.00 0.00 C ATOM 5520 C2 CYT 23 8.658 8.100-10. 900 1.00 0.00 C ATOM 5521 02 CYT 23 8.745 8.885-11. 842 1.00 0.00 0 ATOM 5522 N3 CYT 23 9.521 7.058-10. 761 1.00 0.00 N ATOM 5523 C4 CYT 23 9.414 6.208-9. 733 1.00 0.00 C ATOM 5524 N4 CYT 23 10.278 5.199-9. 627 1.00 0.00 N ATOM 5525 C5 CYT 23 8.389 6.370-8. 748 1.00 0.00 C ATOM 5526 C2'CYT 23 5.434 8.971-10. 791 1.00 0.00 C ATOM 5527 02'CYT 23 4.964 9.963-11. 711 1.00 0.00 0 ATOM 5528 C3'CYT 23 4.499 8.821-9. 605 1.00 0.00 C ATOM 5529 03'CYT 23 3.158 9. 081-10, 036 1.00 0.00 0 ATOM 5530 1H5'CYT 23 4.828 10.607-6. 672 1.00 0.00 H ATOM 5531 2H5'CYT 23 3. 432 9.660-7. 224 1.00 0. 00 H ATOM 5532 H4'CYT 23 4.536 10.901-9. 085 1.00 0.00 H ATOM 5533 Hl'CYT 23 7.219 10.171-10. 731 1.00 0.00 H ATOM 5534 H6 CYT 23 6.747 7.559-8. 159 1.00 0.00 H ATOM 5535 1H4 CYT 23 10.209 4.553-8. 854 1.00 0.00 H ATOM 5536 2H4 CYT 23 11.003 5.081-10. 320 1.00 0.00 H ATOM 5537 H5 CYT 23 8.298 5.677-7. 912 1.00 0.00 H ATOM 5538 H2'CYT 23 5.572 8.007-11. 291 1.00 0.00 H ATOM 5539 H02'CYT 23 4.849 10.778-11. 217 1.00 0.00 H ATOM 5540 H3'CYT 23 4.605 7.850-9. 118 1.00 0.00 H ATOM 5541 P GUA 24 2.282 7.927-10. 737 1.00 0.00 P ATOM 5542 01P GUA 24 0.900 8.430-10. 904 1.00 0.00 O ATOM 5543 02P GUA 24 2.521 6.657-10. 015 1.00 0.00 0 ATOM 5544 05'GUA 24 2.955 7.809-12. 194 1.00 0.00 0 ATOM 5545 C5'GUA 24 2.730 8.813-13. 189 1.00 0.00 C ATOM 5546 C4'GUA 24 2.787 8.223-14. 593 1.00 0.00 C ATOM 5547 04'GUA 24 4.082 7.671-14. 882 1.00 0.00 0 ATOM 5548 C1'GUA 24 3.935 6.330-15. 376 1.00 0.00 C ATOM 5549 N9 GUA 24 4.289 5.339-14. 343 1.00 0.00 N ATOM 5550 C4 GUA 24 4.502 3.997-14. 543 1.00 0.00 C ATOM 5551 N3 GUA 24 4.413 3.352-15. 727 1.00 0. 00 N ATOM 5552 C2 GUA 24 4.673 2.049-15. 612 1.00 0.00 C ATOM 5553 N2 GUA 24 4.617 1.262-16. 686 1.00 0.00 N ATOM 5554 N1 GUA 24 4.996 1.436-14. 417 1.00 0.00 N ATOM 5555 C6 GUA 24 5.092 2.076-13. 189 1.00 0.00 C ATOM 5556 06 GUA 24 5.382 1.437-12. 181 1.00 0.00 O ATOM 5557 C5 GUA 24 4.816 3.463-13. 303 1.00 0.00 C ATOM 5558 N7 GUA 24 4.804 4.458-12. 322 1.00 0.00 N ATOM 5559 C8 GUA 24 4.491 5.503-13. 012 1. 00 0.00 C ATOM 5560 C2'GUA 24 2.476 6.205-15. 784 1.00 0.00 C ATOM 5561 02'GUA 24 2.253 6.714-17. 105 1.00 0.00 0 ATOM 5562 C3'GUA 24 1.809 7.064-14. 730 1.00 0.00 C ATOM 5563 03'GUA 24 0.575 7.566-15. 252 1.00 0. 00 O ATOM 5564 1H5'GUA 24 3.492 9.586-13. 095 1.00 0.00 H ATOM 5565 2H5'GUA 24 1.747 9.259-13. 030 1.00 0.00 H ATOM 5566 H4'GUA 24 2. 549 8.992-15. 326 1.00 0.00 H ATOM 5567 H1'GUA 24 4.571 6.186-16. 249 1.00 0.00 H ATOM 5568 1H2 GUA 24 4.378 1.653-17. 586 1.00 0. 00 H ATOM 5569 2H2 GUA 24 4. 813 0.275-16. 600 1.00 0.00 H ATOM 5570 H1 GUA 24 5. 182 0.447-14. 413 1. 00 0.00 H

ATOM 5571 H8 GUA 24 4.393 6.481-12. 542 1.00 0.00 H ATOM 5572 H2'GUA 24 2.144 5.167-15. 699 1.00 0.00 H ATOM 5573 H02'GUA 24 2.639 6.086-17. 721 1.00 0.00 H ATOM 5574 H3'GUA 24 1.678 6. 525-13. 790 1.00 0.00 H ATOM 5575 P ADE 25-0.813 6.819-14. 924 1.00 0.00 P ATOM 5576 01P ADE 25-1.908 7.566-15. 583 1.00 0.00 0 ATOM 5577 02P ADE 25-0.868 6. 561-13.467 1.00 0.00 0 ATOM 5578 05'ADE 25-0.634 5.409-15. 680 1.00 0.00 0 ATOM 5579 C5'ADE 25-0.527 5.361-17. 105 1.00 0.00 C ATOM 5580 C4'ADE 25 0.015 4.018-17. 586 1.00 0.00 C ATOM 5581 04'ADE 25 1.295 3.726-17. 019 1.00 0.00 0 ATOM 5582 C1'ADE 25 1.393 2.309-16. 767 1.00 0.00 C ATOM 5583 N9 ADE 25 1.601 2.030-15. 332 1.00 0.00 N ATOM 5584 C4 ADE 25 2. 003 0.834-14. 781 1.00 0.00 C ATOM 5585 N3 ADE 25 2.278-0. 302-15.452 1.00 0.00 N ATOM 5586 C2 ADE 25 2.642-1. 277-14.625 1.00 0.00 C ATOM 5587 N1 ADE 25 2.742-1. 211-13.296 1.00 0.00 N ATOM 5588 C6 ADE 25 2.461-0. 067-12.648 1.00 0.00 C ATOM 5589 N6 ADE 25 2.569-0. 023-11.320 1.00 0.00 N ATOM 5590 C5 ADE 25 2.067 1.031-13. 421 1.00 0. 00 C ATOM 5591 N7 ADE 25 1.709 2.344-13. 093 1.00 0.00 N ATOM 5592 C8 ADE 25 1.458 2. 844-14. 257 1.00 0.00 C ATOM 5593 C2'ADE 25 0.083 1.696-17. 258 1.00 0.00 C ATOM 5594 02'ADE 25 0.193 1.239-18. 612 1.00 0.00 O ATOM 5595 C3'ADE 25-0.867 2.870-17. 138 1.00 0.00 C ATOM 5596 03'ADE 25-1.927 2.709-18. 086 1.00 0.00 0 ATOM 5597 1H5'ADE 25 0.142 6.154-17. 440 1.00 0.00 H ATOM 5598 2H5'ADE 25-1.513 5. 521-17. 541 1.00 0.00 H ATOM 5599 H4'ADE 25 0.094 4.020-18. 672 1.00 0.00 H ATOM 5600 H1'ADE 25 2.222 1.897-17. 341 1.00 0.00 H ATOM 5601 H2 ADE 25 2.888-2. 236-15.084 1.00 0.00 H ATOM 5602 1H6 ADE 25 2.361 0.833-10. 825 1.00 0.00 H ATOM 5603 2H6 ADE 25 2.860-0. 845-10.809 1.00 0. 00 H ATOM 5604 H8 ADE 25 1.150 3.883-14. 371 1. 00 0.00 H ATOM 5605 H2'ADE 25-0.228 0.885-16. 594 1.00 0.00 H ATOM 5606 H02'ADE 25 0.750 0.457-18. 604 1.00 0.00 H ATOM 5607 H3'ADE 25-1.230 3.001-16. 118 1.00 0.00 H ATOM 5608 P CYT 26-3.236 1. 854-17.707 1.00 0.00 P ATOM 5609 01P CYT 26-3.688 2.270-16. 361 1.00 0.00 O ATOM 5610 02P CYT 26-4.174 1.911-18. 851 1.00 0.00 0 ATOM 5611 05'CYT 26-2.655 0.356-17. 602 1.00 0.00 O ATOM 5612 C5'CYT 26-2. 357-0. 395-18.783 1.00 0.00 C ATOM 5613 C4'CYT 26-1.898-1. 810-18.444 1.00 0.00 C ATOM 5614 04'CYT 26-0. 658-1. 813-17.721 1.00 0.00 O ATOM 5615 Cl'CYT 26-0. 736-2. 767-16.642 1.00 0.00 C ATOM 5616 N1 CYT 26-0. 776-2. 087-15.327 1.00 0.00 N ATOM 5617 C6 CYT 26-1. 435-0. 902-15.172 1.00 0.00 C ATOM 5618 C2 CYT 26-0. 128-2. 699-14.261 1.00 0.00 C ATOM 5619 02 CYT 26 0.460-3. 767-14.423 1.00 0.00 O ATOM 5620 N3 CYT 26-0.165-2. 086-13.046 1.00 0.00 N ATOM 5621 C4 CYT 26-0.809-0. 923-12.881 1.00 0.00 C ATOM 5622 N4 CYT 26-0.820-0. 346-11.680 1.00 0.00 N ATOM 5623 C5 CYT 26-1. 477-0.291-13. 976 1.00 0. 00 C ATOM 5624 C2'CYT 26-2. 015-3. 560-16. 887 1.00 0.00 C ATOM 5625 02'CYT 26-1. 790-4.665-17. 772 1.00 0. 00 O ATOM 5626 C3'CYT 26-2.888-2. 500-17.523 1.00 0.00 C ATOM 5627 03'CYT 26-3. 894-3. 133-18. 319 1. 00 0. 00 0 ATOM 5628 1H5'CYT 26-1.569 0.112-19. 341 1.00 0.00 H ATOM 5629 2H5'CYT 26-3.252-0. 451-19. 402 1.00 0.00 H ATOM 5630 H4'CYT 26-1. 783-2.388-19. 360 1.00 0.00 H

ATOM 5631 H1 CYT 26 0.123-3. 437-16.684 1.00 0.00 H ATOM 5632 H6 CYT 26-1.928-0. 442-16.027 1.00 0.00 H ATOM 5633 1H4 CYT 26-1.299 0.533-11. 546 1.00 0. 00 H ATOM 5634 2H4 CYT 26-0.349-0. 788-10.903 1.00 0.00 H ATOM 5635 H5 CYT 26-2. 011 0.648-13. 845 1.00 0.00 H ATOM 5636 H2'CYT 26-2.444-3. 894-15.939 1.00 0.00 H ATOM 5637 H02'CYT 26-1.382-4. 314-18.568 1.00 0.00 H ATOM 5638 H3'CYT 26-3.304-1. 815-16.780 1.00 0.00 H ATOM 5639 P CYT 27-5.407-3. 241-17.780 1.00 0.00 P ATOM 5640 01P CYT 27-5. 800-1.924-17. 230 1.00 0.00 0 ATOM 5641 02P CYT 27-6.230-3. 878-18.832 1.00 0.00 0 ATOM 5642 05'CYT 27-5.262-4. 276-16.556 1.00 0.00 0 ATOM 5643 C5'CYT 27-4.825-5. 616-16.793 1.00 0.00 C ATOM 5644 C4'CYT 27-4.390-6. 307-15.504 1.00 0.00 C ATOM 5645 04'CYT 27-3.352-5. 599-14.835 1.00 0.00 0 ATOM 5646 C1'CYT 27-3.411-5. 923-13.432 1.00 0.00 C ATOM 5647 N1 CYT 27-3.335-4. 715-12.578 1.00 0.00 N ATOM 5648 C6 CYT 27-3.747-3. 493-13.031 1.00 0.00 C ATOM 5649 C2. CYT 27-2.844-4. 881-11.291 1.00 0.00 C ATOM 5650 02 CYT 27-2.485-5. 991-10.907 1.00 0.00 0 ATOM 5651 N3 CYT 27-2.779-3. 794-10.477 1.00 0.00 N ATOM 5652 C4 CYT 27-3.179-2. 590-10.904 1.00 0.00 C ATOM 5653 N4 CYT 27-3.100-1. 547-10.079 1.00 0.00 N ATOM 5654 C5 CYT 27-3.687-2. 410-12. 229 1.00 0.00 C ATOM 5655 C2'CYT 27-4.738-6. 661-13. 211 1. 00 0.00 C ATOM 5656 02'CYT 27-4.530-8. 071-13.060 1.00 0.00 0 ATOM 5657 C3'CYT 27-5. 505-6.343-14. 483 1.00 0.00 C ATOM 5658 03'CYT 27-6.377-7. 438-14.784 1.00 0.00 0 ATOM 5659 1H5'CYT 27-3.984-5. 599-17.487 1.00 0.00 H ATOM 5660 2H5'CYT 27-5.643-6. 182-17.240 1.00 0.00 H ATOM 5661 H4'CYT 27-4.055-7. 320-15. 721 1.00 0.00 H ATOM 5662 H1'CYT 27-2. 586-6. 592-13.185 1.00 0.00 H ATOM 5663 H6 CYT 27-4. 127-3.392-14. 048 1.00 0.00 H ATOM 5664 1H4 CYT 27-3.399-0. 634-10.390 1.00 0. 00 H ATOM 5665 2H4 CYT 27-2.744-1. 671-9.142 1.00 0.00 H ATOM 5666 H5 CYT 27-4.019-1. 430-12.576 1.00 0.00 H ATOM 5667 H2'CYT 27-5.258-6. 247-12.345 1.00 0.00 H ATOM 5668 H02'CYT 27-4.108-8. 208-12.209 1.00 0.00 H ATOM 5669 H3'CYT 27-6.032-5. 390-14. 415 1.00 0. 00 H ATOM 5670 P GUA 28-7.770-7. 610-13.994 1. 00 0.00 P ATOM 5671 01P GUA 28-8.545-8. 686-14.653 1.00 0.00 O ATOM 5672 02P GUA 28-8.373-6. 270-13. 818 1.00 0.00 0 ATOM 5673 05'GUA 28-7.293-8. 141-12.549 1.00 0.00 0 ATOM 5674 C5'GUA 28-7.116-9. 540-12.310 1.00 0.00 C ATOM 5675 C4'GUA 28-6.967-9. 848-10.822 1.00 0.00 C ATOM 5676 04'GUA 28-5.772-9. 287-10.271 1.00 0.00 0 ATOM 5677 C1'GUA 28-6.024-8. 885-8.908 1.00 0.00 C ATOM 5678 N9 GUA 28-5.787-7. 439-8. 724 1.00 0.00 N ATOM 5679 C4 GUA 28-5.414-6. 809-7.557 1.00 0.00 C ATOM 5680 N3 GUA 28-5.204-7. 410-6.364 1.00 0.00 N.

ATOM 5681 C2 GUA 28-4.853-6. 538-5.413 1.00 0.00 C ATOM 5682 N2 GUA 28-4.617-6. 966-4.173 1.00 0.00 N ATOM 5683 N1 GUA 28-4.721-5. 181-5.630 1.00 0. 00 N ATOM 5684 C6 GUA 28-4.931-4. 541-6.844 1.00 0.00 C ATOM 5685 06 GUA 28-4.789-3. 323-6.932 1.00 0.00 O ATOM 5686 C5 GUA 28-5.305-5. 461-7.861 1.00 0.00 C ATOM 5687 N7 GUA 28-5.606-5. 234-9.207 1.00 0.00 N ATOM 5688 C8 GUA 28-5. 871-6. 427-9.622 1.00 0.00 C ATOM 5689 C2'GUA 28-7. 484-9. 244-8. 620 1.00 0.00 C ATOM 5690 02'GUA 28-7.597-10. 541-8. 021 1.00 0.00 0

ATOM 5691 C3'GUA 28-8.081-9. 218-10.012 1.00 0.00 C ATOM 5692 03'GUA 28-9.223-10. 079-10.047 1.00 0.00 0 ATOM 5693 1H5'GUA 28-6.224-9. 882-12.835 1.00 0.00 H ATOM 5694 2H5'GUA 28-7.983-10. 077-12.697 1.00 0.00 H ATOM 5695 H4'GUA 28-6.964-10. 926-10.667 1.00 0.00 H ATOM 5696 H1'GUA 28-5.374-9. 449-8. 238 1.00 0.00 H ATOM 5697 1H2 GUA 28-4.703-7. 948-3.954 1.00 0.00 H ATOM 5698 2H2 GUA 28-4. 354-6. 309-3.454 1.00 0.00 H ATOM 5699 H1 GUA 28-4.449-4. 588-4.859 1.00 0. 00 H ATOM 5700 H8 GUA 28-6.160-6. 614-10.655 1.00 0.00 H ATOM 5701 H2'GUA 28-7.945-8. 478-7.992 1.00 0.00 H ATOM 5702 H02'GUA 28-7.150-11. 163-8.599 1.00 0.00 H ATOM 5703 H3'GUA 28-8.306-8. 202-10.342 1.00 0.00 H ATOM 5704 P CYT 29-10.704-9. 469-9.879 1.00 0.00 P ATOM 5705 O1P CYT 29-10.796-8. 241-10.700 1.00 0.00 0 ATOM 5706 02P CYT 29-11.681-10. 563-10.077 1.00 0.00 0 ATOM 5707 05'CYT 29-10.730-9. 041-8.328 1.00 0.00 0 ATOM 5708 C5'CYT 29-10.812-10. 035-7.302 1.00 0.00 C ATOM 5709 C4'CYT 29-10.496-9. 454-5.927 1.00 0.00 C ATOM 5710 04'CYT 29-9.178-8. 896-5.877 1.00 0.00 0 ATOM 5711 C1'CYT 29-9.198-7. 691-5.085 1.00 0.00 C ATOM 5712 N1 CYT 29-8.846-6. 503-5.896 1.00 0.00 N ATOM 5713 C6 CYT 29-9.176-6. 428-7.220 1.00 0.00 C ATOM 5714 C2 CYT 29-8.168-5. 471-5.260 1.00 0.00 C ATOM 5715 02 CYT 29-7.883-5. 560-4.068 1.00 0.00 0 ATOM 5716 N3 CYT 29-7.836-4. 371-5.989 1.00 0.00 N ATOM 5717 C4 CYT 29-8.152-4. 283-7.287 1.00 0.00 C ATOM 5718 N4 CYT 29-7.803-3. 194-7.971 1.00 0.00 N ATOM 5719 C5 CYT 29-8.850-5. 342-7.948 1.00 0.00 C ATOM 5720 C2'CYT 29-10.614-7. 575-4. 527 1.00 0.00 C ATOM 5721 02'CYT 29-10.731-8. 218-3.252 1.00 0.00 0 ATOM 5722 C3'CYT 29-11.416-8. 295-5.591 1.00 0.00 C ATOM 5723 03'CYT 29-12.612-8. 811-4.999 1.00 0.00 0 ATOM 5724 1H5'CYT 29-10.104-10. 834-7.521 1.00 0.00 H ATOM 5725 2H5'CYT 29-11.821-10. 448-7.289 1.00 0.00 H ATOM 5726 H4'CYT 29-10.590-10. 229-5.169 1.00 0.00 H ATOM 5727 H1'CYT 29-8.492-7. 790-4.260 1.00 0.00 H ATOM 5728 H6 CYT 29-9.709-7. 253-7.692 1.00 0.00 H ATOM 5729 1H4 CYT 29-8.032-3. 119-8.952 1.00 0.00 H ATOM 5730 2H4 CYT 29-7.314-2. 441-7.507 1.00 0.00 H ATOM 5731 H5 CYT 29-9.109-5. 274-9.005 1.00 0.00 H ATOM 5732 H2'CYT 29-10.913-6. 526-4.468 1.00 0.00 H ATOM 5733 H02'CYT 29-10.461-9. 132-3.368 1.00 0.00 H ATOM 5734 H3'CYT 29-11.612-7. 659-6.456 1.00 0.00 H ATOM 5735 P CYT 30-13.956-7. 923-4.972 1.00 0.00 P ATOM 5736 01P CYT 30-14.126-7. 298-6. 303 1.00 0.00 0 ATOM 5737 02P CYT 30-15.043-8. 749-4.400 1.00 0.00 0 ATOM 5738 05'CYT 30-13.591-6. 764-3.914 1.00 0.00 0 ATOM 5739 C5'CYT 30-13.557-7. 044-2.511 1.00 0.00 C ATOM 5740 C4'CYT 30-12.958-5. 884-1.719 1.00 0.00 C ATOM 5741 04'CYT 30-11.632-5. 575-2. 152 1.00 0.00 0 ATOM 5742 C1'CYT 30-11.424-4. 154-2.055 1.00 0.00 C ATOM 5743 N1 CYT 30-11.105-3. 562-3.374 1.00 0.00 N ATOM 5744 C6 CYT 30-11.600-4. 100-4.528 1.00 0.00 C ATOM 5745 C2 CYT 30-10.285-2. 443-3.391 1.00 0.00 C ATOM 5746 02 CYT 30-9.858-1. 971-2.339 1.00 0.00 0 ATOM 5747 N3 CYT 30-9.979-1. 885-4.594 1.00 0.00 N ATOM 5748 C4 CYT 30-10.456-2. 400-5.733 1.00 0.00 C ATOM 5749 N4 CYT 30-10.138-1. 826-6.893 1.00 0.00 N ATOM 5750 C5 CYT 30-11.302-3. 554-5.722 1.00 0.00 C

ATOM 5751 C2'CYT 30-12.721-3. 574-1.487 1.00 0.00 C ATOM 5752 02'CYT 30-12.666-3. 473-0.059 1.00 0.00 O ATOM 5753 C3'CYT 30-13.740-4. 602-1.932 1.00 0.00 C ATOM 5754 03'CYT 30-14.928-4. 558-1.133 1.00 0.00 0 ATOM 5755 1H5'CYT 30-12.956-7. 937-2.341 1.00 0.00 H ATOM 5756 2H5'CYT 30-14.573-7. 227-2.161 1.00 0.00 H ATOM 5757 H4'CYT 30-12.943-6. 132-0.659 1.00 0.00 H ATOM 5758 Hl'CYT 30-10.607-3. 956-1.361 1.00 0.00 H ATOM 5759 H6 CYT 30-12.247-4. 976-4.482 1.00 0.00 H ATOM 5760 1H4 CYT 30-10.492-2. 207-7.759 1.00 0.00 H ATOM 5761 2H4 CYT 30-9.550-1. 006-6.905 1.00 0.00 H ATOM 5762 H5 CYT 30-11.691-3. 977-6.648 1.00 0.00 H ATOM 5763 H2'CYT 30-12.933-2. 603-1.943 1.00 0.00 H ATOM 5764 H02'CYT 30-13.562-3. 324 0.250 1.00 0.00 H ATOM 5765 H3'CYT 30-13.970-4. 469-2.994 1.00 0.00 H ATOM 5766 H03'CYT 30-15.395-3. 750-1.358 1.00 0.00 H TER ATOM 5767 05'GUA 1-1.024 13.976 10.610 1.00 0.00 0 ATOM 5768 C5'GUA 1-2.326 13.976 11.203 1.00 0.00 C ATOM 5769 C4'GUA 1-3.350 14.676 10.312 1.00 0.00 C ATOM 5770 04'GUA 1-2.976 16.039 10.054 1.00 0.00 O ATOM 5771 C1'GUA 1-3.067 16.305 8.643 1.00 0.00 C ATOM 5772 N9 GUA 1-1.730 16.356 8.020 1.00 0.00 N ATOM 5773 C4 GUA 1-1.427 16.812 6.756 1.00 0.00 C ATOM 5774 N3 GUA 1-2.308 17.304 5.857 1.00 0.00 N ATOM 5775 C2 GUA 1-1.715 17.665 4.715 1.00 0.00 C ATOM 5776 N2 GUA 1-2.442 18.161 3.714 1.00 0.00 N ATOM 5777 N1 GUA 1-0.359 17.548 4.486 1. 00 0.00 N ATOM 5778 C6 GUA 1 0.566 17.048 5.393 1.00 0.00 C ATOM 5779 06 GUA 1 1.755 16.986 5.090 1.00 0.00 0 ATOM 5780 C5 GUA 1-0.056 16.660 6.609 1.00 0.00 C ATOM 5781 N7 GUA 1 0.505 16.113 7.767 1.00 0.00 N ATOM 5782 C8 GUA 1-0.533 15.972 8.520 1.00 0.00 C ATOM 5783 C2'GUA 1-3.889 15.164 8.069 1.00 0.00 C ATOM 5784 02'GUA 1-5.295 15.407 8.201 1.00 0. 00 O ATOM 5785 C3'GUA 1-3.433 14.015 8.943 1.00 0.00 C ATOM 5786 03'GUA 1-4.465 13.023 8.971 1.00 0.00 O ATOM 5787 H5'GUA 1-1.078 13.461 9.802 1.00 0.00 H ATOM 5788 1H5'GUA 1-2.280 14.489 12.163 1.00 0.00 H ATOM 5789 2H5'GUA 1-2.642 12.945 11.365 1.00 0.00 H ATOM 5790 H4'GUA 1-4.328 14.654 10.789 1.00 0.00 H ATOM 5791 H1'GUA 1-3.586 17.250 8.479 1.00 0.00 H ATOM 5792 1H2 GUA 1-3.441 18.265 3.818 1. 00 0.00 H ATOM 5793 2H2 GUA 1-1.993 18.430 2.849 1.00 0.00 H ATOM 5794 Hl GUA 1 0.011 17.842 3.596 1.00 0.00 H ATOM 5795 H8 GUA 1-0.452 15.547 9.518 1.00 0.00 H ATOM 5796 H2'GUA 1-3.612 14.986 7.028 1.00 0.00 H ATOM 5797 H02'GUA 1-5.714 14.564 8.386 1.00 0.00 H ATOM 5798 H3'GUA 1-2.471 13.613 8.620 1. 00-0. 00 H ATOM 5799 P GUA 2-4.457 11.804 7.918 1.00 0.00 P ATOM 5800 01P GUA 2-3. 122 11.165 7.958 1.00 0. 00 O ATOM 5801 02P GUA 2-5.672 10.990 8.144 1.00 0.00 0 ATOM 5802 05'GUA 2-4.610 12.559 6.503 1. 00 0.00 O ATOM 5803 C5'GUA 2-5.857 13.148 6.122 1.00 0.00 C ATOM 5804 C4'GUA 2-5.735 13. 940 4. 823 1.00 0.00 C ATOM 5805 04'GUA 2-4.737 14.961 4.916 1. 00 0.00 O ATOM 5806 C1'GUA 2-4.059 15.084 3.649 1.00 0.00 C ATOM 5807 N9 GUA 2-2.615 14.801 3. 781 1. 00 0.00 N ATOM 5808 C4 GUA 2-1.645 15.025 2. 828 1.00 0. 00 C ATOM 5809 N3 GUA 2-1.853 15.521 1.587 1. 00 0. 00 N

ATOM 5810 C2 GUA 2-0.718 15.627 0.889 1. 00 0.00 C ATOM 5811 N2 GUA 2-0.748 16.089-0. 361 1.00 0.00 N ATOM 5812 N1 GUA 2 0. 521 15.271 1.382 1.00 0. 00 N ATOM 5813 C6 GUA 2 0.760 14.761 2.651 1.00 0.00 C ATOM 5814 06 GUA 2 1.905 14.481 2.998 1.00 0.00 0 ATOM 5815 C5 GUA 2-0.442 14.642 3.400 1.00 0.00 C ATOM 5816 N7 GUA 2-0.642 14.176 4.703 1.00 0.00 N ATOM 5817 C8 GUA 2-1.920 14.304 4.835 1.00 0.00 C ATOM 5818 C2'GUA 2-4.732 14.088 2.705 1.00 0.00 C ATOM 5819 02'GUA 2-5.781 14.708 1.951 1.00 0.00 0 ATOM 5820 C3'GUA 2-5.274 13.061 3.678 1.00 0.00 C ATOM 5821 03'GUA 2-6.419 12.431 3.094 1.00 0.00 0 ATOM 5822 1H5'GUA 2-6.193 13.815 6.915 1.00 0.00 H ATOM 5823 2H5'GUA 2-6.596 12.357 5.987 1.00 0.00 H ATOM 5824 H4'GUA 2-6.693 14.394 4.577 1.00 0.00 H ATOM 5825 H1'GUA 2-4.196 16.095 3.264 1.00 0.00 H ATOM 5826 1H2 GUA 2-1.627 16.359-0. 778 1.00 0.00 H ATOM 5827 2H2 GUA 2 0. 108 16.168-0. 890 1.00 0.00 H ATOM 5828 H1 GUA 2 1.333 15.386 0.792 1.00 0.00 H ATOM 5829 H8 GUA 2-2.421 14.019 5.759 1.00 0.00 H ATOM 5830 H2'GUA 2-3.989 13.634 2.045 1. 00 0. 00 H ATOM 5831 H02'GUA 2-6.392 15.097 2.580 1.00 0.00 H ATOM 5832 H3'GUA 2-4.510 12.346 3.987 1.00 0.00 H ATOM 5833 P CYT 3-6.251 11.113 2.184 1.00 0.00 P ATOM 5834 O1P CYT 3-7.601 10. 596. 1.865 1.00 0.00 0 ATOM 5835 02P CYT 3-5.256 10.227 2.830 1.00 0.00 0 ATOM 5836 05'CYT 3-5.599 11.699 0.833 1.00 0.00 0 ATOM 5837 C5'CYT 3-6.427 12. 193-0. 224 1.00 0.00 C ATOM 5838 C4'CYT 3-5.619 12.455-1. 493 1.00 0.00 C ATOM 5839 04'CYT 3-4.644 13.493-1. 302 1.00 0.00 0 ATOM 5840 C1'CYT 3-3.391 13.083-1. 889 1.00 0. 00 C ATOM 5841 N1 CYT 3-2.394 12.750-0. 846 1.00 0.00 N ATOM 5842 C6 CYT 3-2.785 12.241 0.358 1.00 0.00 C ATOM 5843 C2 CYT 3-1.052 12.967-1. 137 1.00 0.00 C ATOM 5844 02 CYT 3-0.719 13.417-2. 233 1.00 0.00 0 ATOM 5845 N3 CYT 3-0. 128 12.659-0. 185 1.00 0.00 N ATOM 5846 C4 CYT 3-0.502 12.159 1.001 1.00 0.00 C ATOM 5847 N4 CYT 3 0.426 11.871 1.912 1.00 0.00 N ATOM 5848 C5 CYT 3-1.881 11.934 1.302 1.00 0.00 C ATOM 5849 C2'CYT 3-3.723 11.862-2. 735 1.00 0.00 C ATOM 5850 02'CYT 3-4.200 12.233-4. 034 1.00 0.00 0 ATOM 5851 C3'CYT 3-4.812 11.232-1. 895 1.00 0.00 C ATOM 5852 03'CYT 3-5.617 10.393-2. 727 1.00 0.00 0 ATOM 5853 1H5'CYT 3-6.900 13.122 0.096 1.00 0.00 H ATOM 5854 2H5'CYT 3-7.201 11.457-0. 443 1. 00 0.00 H ATOM 5855 H4'CYT 3-6.290 12.735-2. 305 1.00 0.00 H ATOM 5856 Hl'CYT 3-3.007 13.879-2. 527 1.00 0.00 H ATOM 5857 H6 CYT 3-3.845 12.084 0.558 1.00 0.00 H ATOM 5858 1H4 CYT 3 0.153 11.496 2.809 1.00 0. 00 H ATOM 5859 2H4 CYT 3 1.402 12.028 1.707 1.00 0.00 H ATOM 5860 H5 CYT 3-2.189 11.520 2.261 1.00 0.00 H ATOM 5861 H2'CYT 3-2.857 11.200-2. 805 1.00 0.00 H ATOM 5862 H02'CYT 3-3.440 12.518-4. 547 1.00 0.00 H ATOM 5863 H3'CYT 3-4.405 10. 705-1. 028 1.00 0.00 H ATOM 5864 P GUA 4-5.291 8. 821-2.858 1.00 0. 00 P ATOM 5865 O1P GUA 4-6. 282 8.217-3. 776 1.00 0.00 0 ATOM 5866 02P GUA 4-5.115 8. 269-1. 496 1.00 0.00 0 ATOM 5867 05'GUA 4-3.856 8.820-3. 591 1.00 0.00 O ATOM 5868 C5'GUA 4-3.730 9.277-4. 942 1. 00 0.00 C ATOM 5869 C4'GUA 4-2.279 9.585-5. 302 1. O0 0.00 C

ATOM 5870 04'GUA 4-1.704 10.547-4. 413 1.00 0.00 O ATOM 5871 Cl'GUA 4-0.315 10.225-4. 197 1.00 0.00 C ATOM 5872 N9 GUA 4-0.037 9.951-2. 772 1.00 0.00 N ATOM 5873 C4 GUA 4 1.205 9.867-2. 186 1.00 0.00 C ATOM 5874 N3 GUA 4 2.390 10.005-2. 822 1.00 0.00 N ATOM 5875 C2 GUA 4 3.427 9.870-1. 991 1.00 0.00 C ATOM 5876 N2 GUA 4 4.670 9.967-2. 461 1.00 0.00 N ATOM 5877 N1 GUA 4 3.298 9.621-0. 639 1.00 0.00 N ATOM 5878 C6 GUA 4 2.093 9.478 0.036 1.00 0.00 C ATOM 5879 06 GUA 4 2.085 9.273 1.247 1.00 0.00 0 ATOM 5880 C5 GUA 4 0.985 9.616-0. 841 1.00 0.00 C ATOM 5881 N7 GUA 4-0.385 9.539-0. 573 1.00 0.00 N ATOM 5882 C8 GUA 4-0.893 9.743-1. 741 1.00 0.00 C ATOM 5883 C2'GUA 4-0.023 8.997-5. 055 1.00 0.00 C ATOM 5884 02'GUA 4 0.487 9.368-6. 341 1.00 0.00 0 ATOM 5885 C3'GUA 4-1.395 8.362-5. 156 1.00 0.00 C ATOM 5886 03'GUA 4-1.463 7.596-6. 364 1.00 0.00 0 ATOM 5887 lH5'GUA 4-4.327 10.180-5. 069 1.00 0.00 H ATOM 5888 2H5'GUA 4-4.107 8.505-5. 614 1.00 0.00 H ATOM 5889 H4'GUA 4-2.224 9.960-6. 323 1.00 0.00 H ATOM 5890 H1'GUA 4 0.304 11.056-4. 534 1.00 0.00 H ATOM 5891 1H2 GUA 4 4.826 10.144-3. 443 1.00 0.00 H ATOM 5892 2H2 GUA 4 5.456 9.861-1. 837 1.00 0.00 H ATOM 5893 H1 GUA 4 4.131 9.534-0. 076 1.00 0.00 H ATOM 5894 H8 GUA 4-1.971 9.735-1. 895 1.00 0.00 H ATOM 5895 H2'GUA 4 0.669 8.328-4. 535 1.00 0.00 H ATOM 5896 H02'GUA 4 1.393 9.659-6. 216 1.00 0.00 H ATOM 5897 H3'GUA 4-1.643 7.777-4. 269 1.00 0.00 H ATOM 5898 P CYT 5-0.764 6.147-6. 451 1.00 0.00 P ATOM 5899 01P CYT 5-1.008 5.436-5. 176 1.00 0.00 0 ATOM 5900 02P CYT 5-1.158 5.517-7. 732 1.00 0.00 0 ATOM 5901 05'CYT 5 0.803 6.514-6. 529 1.00 0.00 0 ATOM 5902 C5'CYT 5 1.371 7.051-7. 728 1.00 0.00 C ATOM 5903 C4'CYT 5 2.890 7.170-7. 625 1.00 0.00 C ATOM 5904 04'CYT 5 3.282 8.056-6. 570 1.00 0.00 0 ATOM 5905 C1'CYT 5. 4.405 7.497-5. 860 1.00 0.00 C ATOM 5906 N1 CYT 5 4.042 7.144-4. 471 1.00 0.00 N ATOM 5907 C6 CYT 5 2.770 6.766-4. 155 1.00 0.00 C ATOM 5908 C2 CYT 5 5.042 7.203-3. 509 1.00 0.00 C ATOM 5909 02 CYT 5 6.181 7.549-3. 818 1.00 0.00 0 ATOM 5910 N3 CYT 5 4.723 6.872-2. 229 1.00 0.00 N ATOM 5911 C4 CYT 5 3.479 6.500-1. 905 1.00 0.00 C ATOM 5912 N4 CYT 5 3.203 6.181-0. 642 1.00 0.00 N ATOM 5913 C5 CYT 5 2.448 6.438-2. 892 1.00 0.00 C ATOM 5914 C2'CYT 5 4.829 6.259-6. 643 1.00 0.00 C ATOM 5915 02'CYT 5 5.817 6.573-7. 633 1.00 0.00 0 ATOM 5916 C3'CYT 5 3.519 5.833-7. 273 1.00 0.00 C ATOM 5917 03'CYT 5 3.796 5.127-8. 486 1.00 0.00 0 ATOM 5918 1H5'CYT 5 0.948 8.040-7. 911 1.00 0.00 H ATOM 5919 2H5'CYT 5 1.121 6.397-8. 564 1.00 0.00 H ATOM 5920 H4'CYT 5 3.296 7.530-8. 569 1.00 0.00 H ATOM 5921 H1'CYT 5 5.223 8.219-5. 849 1.00 0.00 H ATOM 5922 H6 CYT 5 2.009 6.728-4. 933 1.00 0.00 H ATOM 5923 1H4 CYT 5 3.929 6.223 0.060 1.00 0.00 H ATOM 5924 2H4 CYT 5 2.268 5.896-0. 386 1.00 0.00 H ATOM 5925 H5 CYT 5 1.436 6.133-2. 633 1.00 0.00 H ATOM 5926 H2'CYT 5 5.189 5.486-5. 957 1.00 0.00 H ATOM 5927 H02'CYT 5 5.469 7.294-8. 163 1.00 0.00 H ATOM 5928 H3'CYT 5 2.902 5.258-6. 582 1.00 0.00 H ATOM 5929 P URI 6 3.489 3.550-8. 602 1.00 0.00 P

ATOM 5930 O1P URI 6 2.188 3.282-7. 947 1.00 0.00 O ATOM 5931 02P URI 6 3.705 3.138-10. 007 1.00 0.00 O ATOM 5932 05'URI 6 4.652 2.900-7. 698 1.00 0.00 0 ATOM 5933 C5'URI 6 5.989 2.793-8. 196 1.00 0.00 C ATOM 5934 C4'URI 6 6.976 2.431-7. 089 1.00 0.00 C ATOM 5935 04'URI 6 6.998 3.425-6. 053 1.00 0.00 0 ATOM 5936 C1'URI 6 6.997 2.778-4. 766 1.00 0.00 C ATOM 5937 N1 URI 6 5.704 2.963-4. 067 1.00 0.00 N ATOM 5938 C6 URI 6 4.551 3.204-4. 767 1.00 0.00 C ATOM 5939 C2 URI 6 5.705 2.882-2. 685 1.00 0.00 C ATOM 5940 02 URI 6 6.729 2.664-2. 039 1.00 0.00 O ATOM 5941 N3 URI 6 4.482 3. 057-2. 066 1.00 0.00 N ATOM 5942 C4 URI 6 3.275 3. 302-2. 696 1.00 0.00 C ATOM 5943 04 URI 6 2.244 3.438-2. 042 1.00 0.00 O ATOM 5944 C5 URI 6 3.366 3.372-4. 136 1.00 0.00 C ATOM 5945 C2'URI 6 7.263 1.306-5. 049 1. 00 0.00 C ATOM 5946 02'URI 6 8.667 1.032-5. 138 1.00 0.00 O ATOM 5947 C3'URI 6 6.575 1.143-6. 387 1.00 0.00 C ATOM 5948 03'URI 6 7.161 0.035-7. 077 1.00 0.00 0 ATOM 5949 1H5'URI 6 6.283 3.747-8. 636 1.00 0.00 H ATOM 5950 2H5'URI 6 6.021 2.022-8. 966 1.00 0.00 H ATOM 5951 H4'URI 6 7.975 2.325-7. 508 1.00 0.00 H ATOM 5952 HOURI 6 7.804 3.180-4. 155 1.00 0.00 H ATOM 5953 H6 URI 6 4.589 3.262-5. 854 1.00 0.00 H ATOM 5954 H3 URI 6 4.468 3.000-1. 059 1.00 0.00 H ATOM 5955 H5 URI 6 2.467 3.562-4. 723 1.00 0.00 H ATOM 5956 H2'URI 6 6.786 0. 681-4.292 1. 00 0.00 H ATOM 5957 H02'URI 6 9.034 1.632-5. 791 1. 00 0.00 H ATOM 5958 H3'URI 6 5.492 1.051-6. 282 1.00 0.00 H ATOM 5959 P CYT 7 6.490-1. 428-6.989 1. 00 0.00 P ATOM 5960 01P CYT 7 5.043-1. 292-7.267 1.00 0.00 0 ATOM 5961 02P CYT 7 7.310-2. 363-7.792 1.00 0.00 0 ATOM 5962 05'CYT 7 6. 669-1. 805-5. 433 1.00 0.00 O ATOM 5963 C5'CYT 7 7.965-2. 088-4.898 1.00 0.00 C ATOM 5964 C4'CYT 7 7.980-1. 996-3.374 1. 00 0.00 C ATOM 5965 04'CYT 7 7.527-0. 716-2.916 1.00 0.00 0 ATOM 5966 C1'CYT 7 6.729-0. 890-1.727 1.00 0.00 C ATOM 5967 N1 CYT 7 5.319-0. 496-1.947 1.00 0.00 N ATOM 5968 C6 CYT 7 4.786-0. 438-3.203 1.00 0.00 C ATOM 5969 C2 CYT 7 4.556-0. 207-0. 824 1.00 0.00 C ATOM 5970 02 CYT 7 5.056-0. 268 0.297 1.00 0.00 O ATOM 5971 N3 CYT 7 3.252 0.136-1. 000 1.00 0.00 N ATOM 5972 C4 CYT 7 2.715 0.195-2. 224 1.00 0.00 C ATOM 5973 N4 CYT 7 1.434 0.531-2. 357 1.00 0.00 N ATOM 5974 C5 CYT 7 3.496-0. 100-3.386 1.00 0.00 C ATOM 5975 C2'CYT 7 6.823-2. 370-1.374 1.00 0.00 C ATOM 5976 02'CYT 7 7.935-2. 634-0.510 1.00 0.00 O ATOM 5977 C3'CYT 7 7. 017-2. 986-2. 743 1.00 0.00 C ATOM 5978 03'CYT 7 7.675-4. 248-2.589 1.00 0.00 O ATOM 5979 1H5'CYT 7 8. 681-1. 373-5.303 1.00 0.00 H ATOM 5980 2H5'CYT 7 8.260-3. 095-5.197 1.00 0.00 H ATOM 5981 H4'CYT 7 8.988-2. 176-3.004 1.00 0.00 H ATOM 5982 H1'CYT 7 7.152-0. 295-0.916 1. 00 0.00 H ATOM 5983 H6 CYT 7 5.411-0. 669-4. 066 1. 00 0.00 H ATOM 5984 1H4 CYT 7 1.015 0.578-3. 275 1.00 0.00 H ATOM 5985 2H4 CYT 7 0.881 0.740-1. 537 1.00 0.00 H ATOM 5986 H5 CYT 7 3.062-0. 052-4.385 1.00 0.00 H ATOM 5987 H2'CYT 7 5.885-2. 714-0.928 1.00 0.00 H ATOM 5988 H02'CYT 7 8.716-2. 262-0.927 1.00 0.00 H ATOM 5989 H3'CYT 7 6.079-3. 061-3.296 1.00 0.00 H

ATOM 5990 P ADE 8 6. 814-5. 600-2. 412 1. 00 0. 00 P ATOM 5991 01P ADE 8 5. 917-5. 734-3. 581 1. 00 0. 00 O ATOM 5992 02P ADE 8 7. 744-6. 699-2. 067 1. 00 0. 00 0 ATOM 5993 05'ADE 8 5. 909-5. 278-1. 117 1. 00 0. 00 O ATOM 5994 C5'ADE 8 6. 508-5. 124 0. 173 1. 00 0. 00 C ATOM 5995 C4'ADE 8 5. 519-4. 559 1. 193 1. 00 0. 00 C ATOM 5996 04'ADE 8 4. 974-3. 301 0. 764 1. 00 0. 00 0 ATOM 5997 CLADE 8 3. 553-3. 287 1. 009 1. 00 0. 00 C ATOM 5998 N9 ADE 8 2. 787-3. 371-0. 253 1. 00 0. 00 N ATOM 5999 C4 ADE 8 1. 436-3. 144-0. 413 1. 00 0. 00 C ATOM 6000 N3 ADE 8 0. 562-2. 792 0. 552 1. 00 0. 00 N ATOM 6001 C2 ADE 8-0. 668-2. 653 0. 064 1. 00 0. 00 C ATOM 6002 N1 ADE 8-1. 057-2. 823-1. 200 1. 00 0. 00 N ATOM 6003 C6 ADE 8-0. 168-3. 175-2. 145 1. 00 0. 00 C ATOM 6004 N6 ADE 8-0. 580-3. 344-3. 401 1. 00 0. 00 N ATOM 6005 C5 ADE 8 1. 162-3. 350-1. 746 1. 00 0. 00 C ATOM 6006 N7 ADE 8 2. 321-3. 704-2. 443 1. 00 0. 00 N ATOM 6007 C8 ADE 8 3. 205-3. 691-1. 503 1. 00 0. 00 C ATOM 6008 C2'ADE 8 3. 281-4. 495 1. 891 1. 00 0. 00 C ATOM 6009 02'ADE 8 3. 498 -4. 196 3. 276 1. 00 0. 00 O ATOM 6010 C3'ADE 8 4. 310-5. 465 1. 357 1. 00 0. 00 C ATOM 6011 03'ADE 8 4. 589-6. 445 2. 362 1. 00 0. 00 0 ATOM 6012 1H5'ADE 8 7. 359-4. 447 0. 093 1. 00 0. 00 H ATOM 6013 2H5'ADE 8 6. 860-6. 095 0. 520 1. 00 0. 00 H ATOM 6014 H4'ADE 8 6. 014-4. 429 2. 153 1. 00 0. 00 H ATOM 6015 Hl'ADE 8 3. 281-2. 380 1. 542 1. 00 0. 00 H ATOM 6016 H2 ADE 8-1. 445-2. 372 0. 775 1. 00 0. 00 H ATOM 6017 1H6 ADE 8-1. 552-3. 205-3. 636 1. 00 0. 00 H ATOM 6018 2H6 ADE 8 0. 080-3. 613-4. 117 1. 00 0. 00 H ATOM 6019 H8 ADE 8 4. 249-3. 930-1. 706 1. 00 0. 00 H ATOM 6020 H2'ADE 8 2. 269-4. 871 1. 720 1. 00 0. 00 H ATOM 6021 H02'ADE 8 3. 554-5. 033 3. 742 1. 00 0. 00 H ATOM 6022 H3'ADE 8 3. 999-5. 908 0. 412 1. 00 0. 00 H ATOM 6023 P ADE 9 5. 142-7. 902 1. 951 1. 00 0. 00 P ATOM 6024 01P ADE 9 4. 836-8. 839 3. 055 1. 00 0. 00 0 ATOM 6025 02P ADE 9 6. 536-7. 753 1. 476 1. 00 0. 00 0 ATOM 6026 05'ADE 9 4. 217-8. 289 0. 689 1. 00 0. 00 0 ATOM 6027 C5'ADE 9 4. 318-9. 581 0. 082 1. 00 0. 00 C ATOM 6028 C4'ADE 9 3. 351-9. 741-1. 093 1. 00 0. 00 C ATOM 6029 04'ADE 9 2. 001-9. 466-0. 700 1. 00 0. 00 0 ATOM 6030 CL'AXE 9 1. 581-8. 202-1. 240 1. 00 0. 00 C ATOM 6031 N9 ADE 9 0. 950-7. 375-0. 194 1. 00 0. 00 N ATOM 6032 C4 ADE 9-0. 298 -6. 797-0. 239 1. 00 0. 00 C ATOM 6033 N3 ADE 9-1. 172-6. 860-1. 261 1. 00 0. 00 N ATOM 6034 C2 ADE 9-2. 288-6. 195-0. 982 1. 00 0. 00 C ATOM 6035 N1 ADE 9-2. 574-5. 529 0. 137 1. 00 0. 00 N ATOM 6036 C6 ADE 9-1. 685-5. 479 1. 143 1. 00 0. 00 C ATOM 6037 N6 ADE 9-1. 989-4. 811 2. 254 1. 00 0. 00 N ATOM 6038 C5 ADE 9-0. 470-6. 147 0. 961 1. 00 0. 00 C ATOM 6039 N7 ADE 9 0. 654-6. 303 1. 776 1. 00 0. 00 N ATOM 6040 C8 ADE 9 1. 417-7. 024 1. 026 1. 00 0. 00 C ATOM 6041 C2'ADE 9 2. 841-7. 539-1. 788 1. 00 0. 00 C ATOM 6042 02'ADE 9 2. 549-6. 681-2. 897 1. 00 0. 00 O ATOM 6043 C3'ADE 9 3. 654-8. 747-2. 212 1. 00 0. 00 C ATOM 6044 03'ADE 9 3. 104-9. 237-3. 449 1. 00 0. 00 0 ATOM 6045 1H5'ADE 9 4. 093-10. 342 0. 830 1. 00 0. 00 H ATOM 6046 2H5'ADE 9 5. 338-9. 727-0. 276 1. 00 0. 00 H ATOM 6047 H4'ADE 9 3. 412-10. 758-1. 473 1. 00 0. 00 H ATOM 6048 HO'AXE 9 0. 873-8. 367-2. 052 1. 00 0. 00 H ATOM 6049 H2 ADE 9-3. 056-6. 199-1. 751 1. 00 0. 00 H

ATOM 6050 1H6 ADE 9-1.327-4. 770 3.016 1.00 0.00 H ATOM 6051 2H6 ADE 9-2.881-4. 344 2.334 1.00 0.00 H ATOM 6052 H8 ADE 9 2.400-7. 344 1.364 1.00 0.00 H ATOM 6053 H2'ADE 9 3.361-6. 999-0.996 1.00 0.00 H ATOM 6054 H02'ADE 9 2.149-7. 225-3.580 1.00 0.00 H ATOM 6055 H3'ADE 9 4.719-8. 524-2.289 1.00 0.00 H ATOM 6056 P URI 10 3.326-10. 760-3.933 1.00 0.00 P ATOM 6057 01P URI 10 2.843-10. 878-5. 327 1.00 0.00 0 ATOM 6058 02P URI 10 4.710-11. 161-3.594 1.00 0.00 0 ATOM 6059 05'URI 10 2.315-11. 569-2.974 1.00 0.00 0 ATOM 6060 C5'URI 10 1.680-12. 773-3.411 1.00 0.00 C ATOM 6061 C4'URI 10 0.160-12. 633-3.397 1.00 0.00 C ATOM 6062 04'URI 10-0.289-11. 679-4.374 1.00 0.00 0 ATOM 6063 C1'URI 10-1.028-12. 351-5.409 1.00 0.00 C ATOM 6064 N1 URI 10-0.665-11. 839-6.751 1.00 0.00 N ATOM 6065 C6 URI 10 0.420-11. 022-6.924 1.00 0.00 C ATOM 6066 C2 URI 10-1. 457-12. 223-7.821 1.00 0.00 C ATOM 6067 02 URI 10-2.440-12. 950-7.686 1.00 0.00 0 ATOM 6068 N3 URI 10-1.082-11. 735-9. 059 1.00 0.00 N ATOM 6069 C4 URI 10-0.003-10. 909-9.320 1.00 0.00 C ATOM 6070 04 URI 10 0.237-10. 536-10.466 1.00 0.00 0 ATOM 6071 C5 URI 10 0.765-10. 558-8.148 1.00 0.00 C ATOM 6072 C2'URI 10-0.676-13. 825-5.267 1.00 0.00 C ATOM 6073 02'URI 10-1.719-14. 674-5.761 1.00 0.00 0 ATOM 6074 C3'URI 10-0.519-13. 946-3.764 1.00 0.00 C ATOM 6075 03'URI 10-1.822-13. 959-3.167 1.00 0.00 0 ATOM 6076 1H5'URI 10 1.968-13. 587-2.745 1.00 0.00 H ATOM 6077 2H5'URI 10 2.010-13. 009-4.423 1.00 0. 00 H ATOM 6078 H4'URI 10-0.168-12. 315-2.409 1.00 0.00 H ATOM 6079 H1'URI 10-2. 098-12. 215-5.243 1.00 0.00 H ATOM 6080 H6 URI 10 1.015-10. 734-6.058 1.00 0.00 H ATOM 6081 H3 URI 10-1.650-12. 008-9.849 1.00 0.00 H ATOM 6082 H5 URI 10 1.637-9. 912-8. 250 1. 00 0.00 H ATOM 6083 H2'URI 10 0.276-14. 036-5.762 1. 00 0.00 H ATOM 6084 H02'URI 10-2.531-14. 416-5.317 1.00 0.00 H ATOM 6085 H3'URI 10 0.078-14. 812-3.478 1.00 0.00 H ATOM 6086 P GUA 11-2.023-14. 397-1.628 1.00 0.00 P ATOM 6087 01P GUA 11-1.231-15. 625-1.389 1.00 0.00 0 ATOM 6088 02P GUA 11-3.473-14. 388-1.332 1.00 0.00 0 ATOM 6089 05'GUA 11-1.338-13. 183-0.815 1.00 0.00 0 ATOM 6090 C5'GUA 11-0. 166-13.405-0. 020 1.00 0.00 C ATOM 6091 C4'GUA 11 0.048-12. 290 1. 004 1.00 0. 00 C ATOM 6092 04'GUA 11 0.193-11. 007 0.374 1.00 0.00 0 ATOM 6093 C1'GUA 11-0.660-10. 054 1.035 1.00 0.00 C ATOM 6094 N9 GUA 11-1.866-9. 782 0.235 1.00 0.00 N ATOM 6095 C4 GUA 11-2.923-8. 980 0.589 1.00 0.00 C ATOM 6096 N3 GUA 11-3.032-8. 279 1.738 1.00 0.00 N ATOM 6097 C2 GUA 11-4.173-7. 591 1.803 1.00 0.00 C ATOM 6098 N2 GUA 11-4. 436-6.840 2.870 1.00 0.00 N ATOM 6099 N1 GUA 11-5.130-7. 600 0.808 1.00 0.00 N ATOM 6100 C6 GUA 11-5.042-8. 311-0. 382 1.00 0. 00 C ATOM 6101 06 GUA 11-5. 952-8.253-1. 205 1.00 0.00 0 ATOM 6102 C5 GUA 11-3.829-9. 045-0.458 1.00 0.00 C ATOM 6103 N7 GUA 11-3.348-9. 882-1. 470 1. 00 0. 00 N ATOM 6104 C8 GUA 11-2.214-10. 258-0. 981 1.00 0.00 C ATOM 6105 C2'GUA 11-1.022-10. 701 2. 362 1. 00 0.00 C ATOM 6106 02'GUA 11 0.017-10. 532 3.334 1.00 0.00 0 ATOM 6107 C3'GUA 11-1.155-12. 144 l.-924 1.00 0.00 C ATOM 6108 03'GUA 11-0.978-12. 995 3.058 1.00 0.00 0 ATOM 6109 lH5'GUA 11 0.704-13. 455-0. 675 1.00 0.00 H

ATOM 6110 2H5'GUA 11-0.268-14. 354 0.507 1. 00 0. 00 H ATOM 6111 H4'GUA 11 0.937-12. 502 1.596 1.00 0.00 H ATOM 6112 H1'GUA 11-0.118-9. 124 1.209 1.00 0.00 H ATOM 6113 1H2 GUA 11-5.299-6. 320 2.920 1.00 0.00 H ATOM 6114 2H2 GUA 11-3. 771-6. 792 3.629 1.00 0.00 H ATOM 6115 H1 GUA 11-5.971-7. 058 0.937 1.00 0. 00 H ATOM 6116 H8 GUA 11-1.558-10. 935-1.523 1.00 0. 00 H ATOM 6117 H2'GUA 11-1. 978-10.317 2.728 1.00 0. 00 H ATOM'6118 H02'GUA 11 0.032-9. 603 3.576 1.00 0. 00 H ATOM 6119 H3'GUA 11-2.096-12. 326 1.402 1.00 0.00 H ATOM 6120 P CYT 12-2. 219-13. 841 3.637 1.00 0. 00 P ATOM 6121 01P CYT 12-2.961-14. 417 2.493 1.00 0.00 O ATOM 6122 02P CYT 12-1.717-14. 726 4.711 1.00 0.00 0 ATOM 6123 05'CYT 12-3.136-12. 700 4.307 1.00 0.00 0 ATOM 6124 C5'CYT 12-2.699-12. 019 5.487 1.00 0.00 C ATOM 6125 C4'CYT 12-3. 595-10. 829 5.817 1.00 0.00 C ATOM 6126 04'CYT 12-3.641-9. 884 4.740 1.00 0.00 0 ATOM 6127 C1'CYT 12-4.991-9. 405 4.581 1.00 0.00 C ATOM 6128 N1 CYT 12-5.575-9. 852 3.294 1.00 0.00 N ATOM 6129 C6 CYT 12-4.954-10. 799 2.528 1.00 0.00 C ATOM 6130 C2 CYT 12-6.769-9. 264 2.891 1.00 0. 00 C ATOM 6131 02 CYT 12-7.318-8. 419 3.598 1.00 0.00 0 ATOM 6132 N3 CYT 12-7.309-9. 653 1.704 1.00 0.00 N ATOM 6133 C4 CYT 12-6.710-10. 578 0.944 1.00 0.00 C ATOM 6134 N4 CYT 12-7.259-10. 923-0.218 1.00 0.00 N ATOM 6135 C5 CYT 12-5.485-11. 189 1.355 1.00 0. 00 C ATOM 6136 C2'CYT 12-5.774-9. 960 5.766 1.00 0.00 C ATOM 6137 02'CYT 12-5.707-9. 081 6.895 1.00 0.00 O ATOM 6138 C3'CYT 12-5.038-11. 257 6.021 1.00 0.00 C ATOM 6139 03'CYT 12-5.215-11. 630 7.391 1.00 0.00 0 ATOM 6140 1H5'CYT 12-1.679-11. 664 5.336 1.00 0.00 H ATOM 6141 2H5'CYT 12-2.712-12. 716 6.325 1.00 0.00 H ATOM 6142 H4'CYT 12-3.230-10. 333 6.715 1.00 0.00 H ATOM 6143 Hl'CYT 12-4.996-8. 316 4.624 1.00 0.00 H ATOM 6144 H6 CYT 12-4.015-11. 239 2.866 1.00 0.00 H ATOM 6145 1H4 CYT 12-6.811-11. 614-0.803 1.00 0.00 H ATOM 6146 2H4 CYT 12-8.119-10. 488-0.519 1.00 0.00 H ATOM 6147 H5 CYT 12-5.001-11. 948 0.740 1.00 0.00 H ATOM 6148 H2'CYT 12-6.809-10. 155 5.478 1.00 0.00 H ATOM 6149 H02'CYT 12-4.781-8. 871 7.036 1.00 0.00 H ATOM 6150 H3'CYT 12-5.342-12. 042 5.326 1. 00 0.00 H ATOM 6151 P URI 13-6.398-12. 635 7.816 1.00 0.00 P ATOM 6152 O1P URI 13-6.301-12. 875 9.273 1.00 0.00 0 ATOM 6153 02P URI 13-6.395-13. 779 6.878 1.00 0.00 O ATOM 6154 05'URI 13-7.717-11. 757 7.535 1.00 0.00 0 ATOM 6155 C5'URI 13-8.031-10. 634 8.363 1.00 0.00 C ATOM 6156 C4'URI 13-9.213-9. 844 7.811 1.00 0.00 C ATOM 6157 04'URI 13-8.938-9. 314 6.510 1.00 0. 00 0 ATOM 6158 C1'URI 13-10.126-9. 403 5.697 1.00 0.00 C ATOM 6159 N1 URI 13-9.924-10. 301 4.536 1.00 0.00 N ATOM 6160 C6 URI 13-8.942-11. 258 4.540 1.00 0.00 C ATOM 6161 C2 URI 13-10.757-10. 128 3.444 1.00 0.00 C ATOM 6162 02 URI 13-11.650-9. 282 3.425 1.00 0.00 0 ATOM 6163 N3 URI 13-10.534-10. 967 2.370 1.00 0.00 N ATOM 6164 C4 URI 13-9.565-11. 952 2.289 1.00 0.00 C ATOM 6165 04 URI 13-9.448-12. 633 1.274 1.00 0. 00 O ATOM 6166 C5 URI 13-8.744-12. 068 3.473 1.00 0.00 C ATOM 6167 C2'URI 13-11.228-9. 928 6.615 1.00 0.00 C ATOM 6168 02'URI 13-11.939-8. 857 7.248 1.00 0.00 0

ATOM 6169 C3'URI 13-10.424-10. 734 7.613 1.00 0. 00 C ATOM 6170 03'URI 13-11.149-10. 805 8.844 1.00 0.00 O ATOM 6171 1H5'URI 13-7.162-9. 979 8.423 1.00 0.00 H ATOM 6172 2H5'URI 13-8.279-10. 990 9.363 1.00 0.00 H ATOM 6173 H4'URI 13-9.461-9. 029 8.488 1.00 0.00 H ATOM 6174 Hl'URI 13-10.396-8. 407 5.343 1.00 0. 00 H ATOM 6175 H6 URI 13-8.313-11. 376 5.422 1.00 0.00 H ATOM 6176 H3 URI 13-11.138-10. 854 1.569 1.00 0.00 H ATOM 6177 H5 URI 13-7.953-12. 817 3.507 1.00 0.00 H ATOM 6178 H2'URI 13-11.906-10. 577 6.058 1.00 0.00 H ATOM 6179 H02'URI 13-11.288-8. 296 7.676 1.00 0.00 H ATOM 6180 H3'URI 13-10.155-11. 716 7.224 1.00 0.00 H ATOM 6181 P CYT 14-12.186-12. 008 9.110 1.00 0.00 P ATOM 6182 O1P CYT 14-12.663-11. 908 10.508 1.00 0.00 O ATOM 6183 02P CYT 14-11.572-13. 265 8.627 1.00 0.00 O ATOM 6184 05'CYT 14-13.408-11. 636 8.131 1.00 0.00 O ATOM 6185 C5'CYT 14-14.274-10. 538 8.430 1.00 0.00 C ATOM 6186 C4'CYT 14-15.287-10. 303 7.314 1.00 0.00 C ATOM 6187 04'CYT 14-14.644-9. 988 6.076 1.00 0.00 O ATOM 6188 C1'CYT 14-15.367-10. 597 4.988 1.00 0.00 C ATOM 6189 N1 CYT 14-14.514-11. 542 4.235 1.00 0.00 N ATOM 6190 C6 CYT 14-13.475-12. 188 4.839 1.00 0.00 C ATOM 6191 C2 CYT 14-14.811-11. 744 2.894 1.00 0.00 C ATOM 6192 02 CYT 14-15.758-11. 157 2.373 1.00 0.00 O ATOM 6193 N3 CYT 14-14.034-12. 606 2.184 1.00 0.00 N ATOM 6194 C4 CYT 14-13. 010-13.245 2.762 1.00 0.00 C ATOM 6195 N4 CYT 14-12.268-14. 079 2.036 1.00 0.00 N ATOM 6196 C5 CYT 14-12.703-13. 042 4.144 1.00 0.00 C ATOM 6197 C2'CYT 14-16.563-11. 315 5.609 1.00 0.00 C ATOM 6198 02'CYT 14-17.739-10. 498 5.579 1.00 0.00 O ATOM 6199 C3'CYT 14-16.087-11. 559 7.028 1. 00 0.00 C ATOM 6200 03'CYT 14-17. 224-11. 583 7.895 1.00 0.00 O ATOM 6201 1H5'CYT 14-13.675-9. 636 8.563 1.00 0.00 H ATOM 6202 2H5'CYT 14-14.809-10. 749 9.356 1.00 0.00 H ATOM 6203 H4'CYT 14-15.960-9. 492 7.589 1.00 0.00 H ATOM 6204 H1'CYT 14-15. 725-9. 818 4.315 1.00 0.00 H ATOM 6205 H6 CYT 14-13.270-12. 014 5.895 1.00 0.00 H ATOM 6206 1H4 CYT 14-11.491-14. 564 2.461 1.00 0.00 H ATOM 6207 2H4 CYT 14-12.488-14. 231 1.061 1.00 0.00 H ATOM 6208 H5 CYT 14-11.876-13. 566 4.620 1.00 0.00 H ATOM 6209 H2'CYT 14-16.733-12. 266 5.098 1.00 0.00 H ATOM 6210 H02'CYT 14-17.529-9. 680 6.036 1.00 0.00 H ATOM 6211 H3'CYT 14-15.478-12. 462 7.106 1.00 0.00 H ATOM 6212 P URI 15-17.970-12. 971 8.226 1.00 0.00 P ATOM 6213 01P URI 15-16.973-13. 910 8.788 1.00 0.00 O ATOM 6214 02P URI 15-19.205-12. 667 8.982 1.00 0.00 O ATOM 6215 05'URI 15-18.389-13. 500 6.763 1.00 0.00 O ATOM 6216 C5'URI 15-19.480-12. 905 6.052 1.00 0.00 C ATOM 6217 C4'URI 15-19.582-13. 450 4.630 1.00 0.00 C ATOM 6218 04'URI 15-18.422-13. 123 3.852 1.00 0. 00 0 ATOM 6219 C1'URI 15-17. 983-14.284 3.123 1.00 0.00 C ATOM 6220 N1 URI 15-16.710-14. 807 3.669 1.00 0.00 N ATOM 6221 C6 URI 15-16.471-14. 806 5.016 1.00 0.00 C ATOM 6222 C2 URI 15-15.779-15. 299 2.772 1.00 0.00 C ATOM 6223 02 URI 15-15.974-15. 307 1.558 1.00 0. 00 O ATOM 6224 N3 URI 15-14.606-15. 785 3.320 1.00 0.00 N ATOM 6225 C4 URI 15-14.288-15. 821 4.666 1.00 0.00 C ATOM 6226 04 URI 15-13.210-16. 275 5.043 1.00 0.00 O ATOM 6227 C5 URI 15-15.317-15. 287 5.528 1.00 0.00 c

ATOM 6228 C2'URI 15-19.104-15. 309 3.260 1.00 0. 00 C ATOM 6229 02'URI 15-20.097-15. 144 2.240 1.00 0.00 0 ATOM 6230 C3'URI 15-19.648-14. 969 4.632 1.00 0.00 C ATOM 6231 03'URI 15-21.022-15. 363 4.696 1.00 0.00 O ATOM 6232 1H5'URI 15-19.334-11. 825 6. 010 1.00 0.00 H ATOM 6233 2H5'URI 15-20.408-13. 119 6.583 1.00 0.00 H ATOM 6234 H4'URI 15-20.469-13. 045 4.144 1.00 0.00 H ATOM 6235 Hl'URI 15-17.851-14. 026 2.072 1.00 0.00 H ATOM 6236 H6 URI 15-17.224-14. 402 5.692 1.00 0.00 H ATOM 6237 H3 URI 15-13.918-16. 150 2.678 1.00 0.00 H ATOM 6238 H5 URI 15-15.166-15. 277 6.607 1.00 0.00 H ATOM 6239 H2'URI 15-18.696-16. 325 3.253 1.00 0.00 H ATOM 6240 H02'URI 15-19. 659-15.261 1.393 1.00 0.00 H ATOM 6241 H3'URI 15-19.045-15. 407 5.431 1.00 0.00 H ATOM 6242 P URI 16-21.424-16. 877 5.060 1.00 0.00 P ATOM 6243 01P URI 16-22. 880-16.918 5.326 1.00 0.00 0 ATOM 6244 02P URI 16-20.474-17. 379 6.079 1.00 0.00 0 ATOM 6245 05'URI 16-21.141-17. 657 3.679 1.00 0.00 0 ATOM 6246 C5'URI 16-21. 567-19. 013 3.510 1.00 0.00 C ATOM 6247 C4'URI 16-22.543-19. 155 2.350 1.00 0. 00 C ATOM 6248 04'URI 16-23.634-18. 231 2.472 1.00 0.00 O ATOM 6249 C1'URI 16-23.764-17. 482 1.262 1.00 0.00 C ATOM 6250 N1 URI 16-24.252-16. 112 1.531 1.00 0.00 N ATOM 6251 C6 URI 16-23.598-15. 292 2.414 1.00 0.00 C ATOM 6252 C2 URI 16-25.389-15. 692 0.863 1. 00 0.00 C ATOM 6253 02 URI 16-25.988-16. 414 0.068 1.00 0. 00 0 ATOM 6254 N3 URI 16-25.817-14. 407 1.142 1.00 0.00 N ATOM 6255 C4 URI 16-25.218-13. 517 2.016 1.00 0.00 C ATOM 6256 04 URI 16-25.688-12. 395 2.186 1.00 0.00 0 ATOM 6257 C5 URI 16-24.038-14. 037 2.669 1.00 0.00 C ATOM 6258 C2'URI 16-22. 373-17.462 0.654 1.00 0.00 C ATOM 6259 02'URI 16-22.419-17. 272-0.765 1. 00 0.00 0 ATOM 6260 C3'URI 16-21.856-18. 843 1.019 1.00 0.00 C ATOM 6261 03'URI 16-22.326-19. 783 0.049 1.00 0. 00 0 ATOM 6262 1H5'URI 16-22.043-19. 352 4. 421 1.00 0.00 H ATOM 6263 2H5'URI 16-20.702-19. 639 3.318 1.00 0.00 H ATOM 6264 H4'URI 16-22.934-20. 171 2.328 1.00 0.00 H ATOM 6265 H1'URI 16-24.451-17. 993 0.586 1.00 0.00 H ATOM 6266 H6 URI 16-22.705-15. 657 2.921 1.00 0.00 H ATOM 6267 H3 URI 16-26.646-14. 088 0.662 1.00 0.00 H ATOM 6268 H5 URI 16-23.496-13. 411 3.377 1.00 0. 00 H ATOM 6269 H2'URI 16-21.761-16. 695 1.136 1.00 0.00 H ATOM 6270 H02'URI 16-22.923-18. 001-1. 134 1.00 0.00 H ATOM 6271 H3'URI 16-20.769-18. 860 1.109 1.00 0.00 H ATOM 6272 P CYT 17-21.746-21. 286 0.038 1.00 0. 00 P ATOM 6273 01P CYT 17-22. 073-21.922 1.334 1.00 0.00 0 ATOM 6274 02P CYT 17-22.160-21. 934-1.227 1.00 0. 00 0 ATOM 6275 05'CYT 17-20.155-21. 038-0.017 1. 00 0. 00 0 ATOM 6276 C5'CYT 17-19.558-20. 473-1.185 1.00 0.00 C ATOM 6277 C4'CYT 17-18.092-20. 116-0.970 1.00 0.00 C ATOM 6278 04'CYT 17-17.933-19. 185 0.112 1.00 0.00 0 ATOM 6279 C1'CYT 17-16.905-19. 663 0.976 1.00 0.00 C ATOM 6280 N1 CYT 17-17.083-19. 179 2.356 1.00 0. 00 N ATOM 6281 C6 CYT 17-18.289-19. 269 2.968 1.00 0.00 C ATOM 6282 C2 CYT 17-15.982-18. 625 2.997 1.00 0.00 C ATOM 6283 02 CYT 17-14.899-18. 554 2.420 1.00 0.00 0 ATOM 6284 N3 CYT 17-16.142-18. 167 4.269 1. 00 0. 00 N ATOM 6285 C4 CYT 17-17.328-18. 248 4.883 1.00 0. 00 C ATOM 6286 N4 CYT 17-17.454-17. 786 6.128 1.00 0.00 N

ATOM 6287 C5 CYT 17-18.459-18. 819 4.222 1.00 0.00 C ATOM 6288 C2'CYT 17-17. 015-21. 172 0.891 1.00 0.00 C ATOM 6289 02'CYT 17-15.804-21. 818 1.303 1.00 0.00 0 ATOM 6290 C3'CYT 17-17.274-21. 354-0.596 1.00 0.00 C ATOM 6291 03'CYT 17-16.016-21. 284-1.279 1.00 0.00 0 ATOM 6292 1H5'CYT 17-20.101-19. 575-1.461 1.00 0.00 H ATOM 6293 2H5'CYT 17-19.629-21. 192-1.996 1.00 0.00 H ATOM 6294 H4'CYT 17-17. 689-19.678-1. 882 1.00 0. 00 H ATOM 6295 H1'CYT 17-15.940-19. 346 0.601 1.00 0.00 H ATOM 6296 H6 CYT 17-19.127-19. 714 2.433 1.00 0.00 H ATOM 6297 1H4 CYT 17-16.657-17. 382 6.600 1.00 0.00 H ATOM 6298 2H4 CYT 17-18.346-17. 839 6.598 1.00 0.00 H ATOM 6299 H5 CYT 17-19.425-18. 883 4.712 1.00 0.00 H ATOM 6300 H2'CYT 17-17.873-21. 525 1.469 1.00 0.00 H ATOM 6301 H02'CYT 17-15.092-21. 451 0.774 1.00 0.00 H ATOM 6302 H3'CYT 17-17. 813-22.275-0. 812 1.00 0.00 H ATOM 6303 P GUA 18-15.715-22. 220-2.556 1.00 0.00 P ATOM 6304 O1P GUA 18-14.294-22. 044-2.933 1.00 0.00 0 ATOM 6305 02P GUA 18-16.240-23. 574-2.273 1.00 0.00 0 ATOM 6306 05'GUA 18-16. 628-21.555-3. 705 1.00 0.00 0 ATOM 6307 C5'GUA 18-16. 323-20.256-4. 221 1.00 0.00 C ATOM 6308 C4'GUA 18-17.452-19. 727-5.101 1.00 0.00 C ATOM 6309 04'GUA 18-18.680-19. 622-4.370 1.00 0.00 0 ATOM 6310 C1'GUA 18-19.359-18. 406-4.735 1.00 0.00 C ATOM 6311 N9 GUA 18-19.436-17. 469-3.595 1.00 0.00 N ATOM 6312 C4 GUA 18-18.449-17. 208-2.668 1.00 0.00 C ATOM 6313 N3 GUA 18-17.219-17. 770-2.637 1. 00 0.00 N ATOM 6314 C2 GUA 18-16.482-17. 319-1.618 1.00 0.00 C ATOM 6315 N2 GUA 18-15.243-17. 776-1.440 1.00 0.00 N ATOM 6316 N1 GUA 18-16.929-16. 386-0.705 1.00 0.00 N ATOM 6317 C6 GUA 18-18.184-15. 794-0. 716 1.00 0.00 C ATOM 6318 06 GUA 18-18.484-14. 969 0.143 1.00 0.00 0 ATOM 6319 C5 GUA 18-18. 975-16.268-1. 795 1.00 0.00 C ATOM 6320 N7 GUA 18-20. 281-15. 933-2. 161 1.00 0.00 N ATOM 6321 C8 GUA 18-20.460-16. 671-3.204 1.00 0.00 C ATOM 6322 C2'GUA 18-18. 558-17. 806-5. 889 1.00 0.00 C ATOM 6323 02'GUA 18-19.032-18. 275-7.157 1.00 0.00 0 ATOM 6324 C3'GUA 18-17.163-18. 317-5. 588 1.00 0.00 C ATOM 6325 03'GUA 18-16.427-18. 393-6. 815 1.00 0.00 0 ATOM 6326 1H5'GUA 18-15.407-20. 312-4.811 1.00 0.00 H ATOM 6327 2H5'GUA 18-16.168-19. 569-3.389 1.00 0.00 H ATOM 6328 H4'GUA 18-17.595-20. 389-5.953 1.00 0.00 H ATOM 6329 H1'GUA 18-20.367-18. 646-5.077 1. 00 0.00 H ATOM 6330 1H2 GUA 18-14.685-17. 435-0.670 1.00 0.00 H ATOM 6331 2H2 GUA 18-14.861-18. 462-2.076 1.00 0.00 H ATOM 6332 H1 GUA 18-16.310-16. 097 0.041 1.00 0.00 H ATOM 6333 H8 GUA 18-21.403-16. 654-3.752 1.00 0.00 H ATOM 6334 H2'GUA 18-18.584-16. 713-5.839 1.00 0.00 H ATOM 6335 H02'GUA 18-19.906-17. 901-7.292 1.00 0.00 H ATOM 6336 H3'GUA 18-16.662-17. 713-4.830 1.00 0.00 H ATOM 6337 P GUA 19-15.023-17. 618-6. 986 1.00 0.00 P ATOM 6338 01P GUA 19-14.170-17. 942-5.820 1.00 0.00 0 ATOM 6339 02P GUA 19-14.521-17. 864-8.357 1.00 0.00 0 ATOM 6340 05'GUA 19-15. 454-16. 069-6. 877 1. 00 0.00 0 ATOM 6341 C5'GUA 19-16.425-15. 517-7.773 1. 00 0.00 C ATOM 6342 C4'GUA 19-17. 329-14.508-7. 067 1.00 0.00 C ATOM 6343 04'GUA 19-17. 828-15.029-5. 824 1.00 0.00 0 ATOM 6344 C1'GUA 19-17. 664-14.040-4. 789 1.00 0.00 C ATOM 6345 N9 GUA 19-16.546-14. 382-3.885 1.00 0. 00 N

ATOM 6346 C4 GUA 19-16.298-13. 837-2.645 1.00 0.00 C ATOM 6347 N3 GUA 19-17.060-12. 911-2.019 1.00 0.00 N ATOM 6348 C2 GUA 19-16.564-12. 573-0.825 1.00 0.00 C ATOM 6349 N2 GUA 19-17.194-11. 671-0.073 1.00 0.00 N ATOM 6350 N1 GUA 19-15.407-13. 111-0.296 1.00 0.00 N ATOM 6351 C6 GUA 19-14.610-14. 062-0.919 1.00 0.00 C ATOM 6352 06 GUA 19-13.597-14. 477-0.362 1.00 0.00 0 ATOM 6353 C5 GUA 19-15.130-14. 426-2.189 1.00 0.00 C ATOM 6354 N7 GUA 19-14.639-15. 338-3.127 1. 00 0.00 N ATOM 6355 C8 GUA 19-15.517-15. 245-4.067 1.00 0.00 C ATOM 6356 C2'GUA 19-17.383-12. 738-5.520 1.00 0.00 C ATOM 6357 02'GUA 19-18.594-12. 103-5.950 1.00 0.00 0 ATOM 6358 C3'GUA 19-16.567-13. 247-6.690 1.00 0.00 C ATOM 6359 03'GUA 19-16.665-12. 309.-7. 765 1.00 0.00 O ATOM 6360 lH5'GUA 19-17.038-16. 323-8.174 1. 00 0. 00 H ATOM 6361 2H5'GUA 19-15.910-15. 020-8.595 1.00 0.00 H ATOM 6362 H4'GUA 19-18.168-14. 251-7.713 1.00 0.00 H ATOM 6363 Hl'GUA 19-18.587-13. 950-4.216 1.00 0.00 H ATOM 6364 1H2 GUA 19-18.046-11. 243-0.407 1.00 0.00 H ATOM 6365 2H2 GUA 19-16.820-11. 415 0.829 1.00 0.00 H ATOM 6366 H1 GUA 19-15.097-12. 802 0.614 1.00 0.00 H ATOM 6367 H8 GUA 19-15.434-15. 839-4.976 1.00 0.00 H ATOM 6368 H2'GUA 19-16.785-12. 071-4.895 1.00 0.00 H ATOM 6369 H02'GUA 19-19.051-11. 798-5.163 1.00 0.00 H ATOM 6370 H3'GUA 19-15.534-13. 459-6.406 1.00 0.00 H ATOM 6371 P ADE 20-15.620-11. 089-7.882 1.00 0.00 P ATOM 6372 01P ADE 20-14.250-11. 644-7.810 1.00 0.00 O ATOM 6373 02P ADE 20-16.015-10. 248-9.034 1.00 0.00 0 ATOM 6374 05'ADE 20-15.899-10. 259-6.530 1.00 0.00 0 ATOM 6375 C5'ADE 20-17.126-9. 546-6.357 1.00 0.00 C ATOM 6376 C4'ADE 20-17.252-8. 970-4.950 1.00 0.00 C ATOM 6377 04'ADE 20-17.197-9. 990-3.944 1.00 0.00 0 ATOM 6378 C1'ADE 20-16.432-9. 507-2.819 1.00 0.00 C ATOM 63.79 N9 ADE 20-15.172-10. 260-2.659 1.00 0.00 N ATOM 6380 C4 ADE 20-14.373-10. 298-1.537 1.00 0.00 C ATOM 6381 N3 ADE 20-14.594-9. 650-0.376 1.00 0.00 N ATOM 6382 C2 ADE 20-13.631-9. 898 0.506 1.00 0.00 C ATOM 6383 N1 ADE 20-12.561-10. 675 0.335 1.00 0.00 N ATOM 6384 C6 ADE 20-12.363-11. 313-0.832 1.00 0.00 C ATOM 6385 N6 ADE 20-11.293-12. 094-0.978 1.00 0.00 N ATOM 6386 C5 ADE 20-13.315-11. 123-1.839 1.00 0.00 C ATOM 6387 N7 ADE 20-13.425-11. 614-3.144 1.00 0.00 N ATOM 6388 C8 ADE 20-14.523-11. 062-3.538 1.00 0.00 C ATOM 6389 C2'ADE 20-16.151-8. 038-3.109 1.00 0.00 C ATOM 6390 02'ADE 20-17.204-7. 194-2.627 1.00 0.00 O ATOM 6391 C3'ADE 20-16.090-8. 053-4.621 1.00 0.00 C ATOM 6392 03'ADE 20-16.376-6. 742-5.114 1.00 0.00 0 ATOM 6393 lH5'ADE 20-17.961-10. 223-6.539 1.00 0.00 H ATOM 6394 2H5'ADE 20-17.167-8. 730-7.080 1.00 0.00 H ATOM 6395 H4'ADE 20-18.189-8. 423-4.858 1.00 0.00 H ATOM 6396 H1'ADE 20-17.028-9. 592-1.910 1.00 0.00 H ATOM 6397 H2 ADE 20-13.727-9. 412 1.477 1.00 0.00 H ATOM 6398 1H6 ADE 20-11.140-12. 583-1.849 1.00 0.00 H ATOM 6399 2H6 ADE 20-10. 638-12.201-0. 217 1.00 0.00 H ATOM 6400 H8 ADE 20-14. 907-11. 223-4. 543 1.00 0.00 H ATOM 6401 H2'ADE 20-15.186-7. 748-2.690 1.00 0.00 H ATOM 6402 H02'ADE 20-17.134-7. 170-1.670 1.00 0.00 H ATOM 6403 H3'ADE 20-15.140-8. 445-4.988 1.00 0.00 H ATOM 6404 P GUA 21-15. 204-5. 644-5.224 1.00 0.00 P

ATOM 6405 01P GUA 21-14.001-6. 302-5.783 1.00 0.00 O ATOM 6406 02P GUA 21-15.758-4. 438-5.881 1.00 0.00 0 ATOM 6407 05'GUA 21-14. 913-5.291-3. 681 1.00 0. 00 ATOM 6408 C5'GUA 21-15.885-4. 587-2.904 1.00 0.00 C ATOM 6409 C4'GUA 21-15.398-4. 344-1.479 1.00 0.00 C ATOM 6410 04'GUA 21-15.168-5. 572-0.776 1.00 0.00 O ATOM 6411 Cl'GUA 21-13.967-5. 456 0.012 1.00 0.00 C ATOM 6412 N9 GUA 21-12.914-6. 364-0.486 1.00 0.00 N ATOM 6413 C4 GUA 21-11.816-6. 812 0.215 1.00 0.00 C ATOM 6414 N3 GUA 21-11.471-6. 448 1.472 1.00 0.00 N ATOM 6415 C2 GUA 21-10.352-7. 052 1.884 1.00 0.00 C ATOM 6416 N2 GUA 21-9. 857-6. 789 3.093 1.00 0.00 N ATOM 6417 N1 GUA 21-9.638-7. 948 1.113 1.00 0.00 N ATOM 6418 C6 GUA 21-9.972-8. 337-0. 176 1.00 0.00 C ATOM 6419 06 GUA 21-9.277-9. 154-0.773 1.00 0.00 0 ATOM 6420 C5 GUA 21-11.156-7. 697-0.624 1.00 0.00 C ATOM 6421 N7 GUA 21-11.822-7. 806-1.847 1.00 0.00 N ATOM 6422 C8 GUA 21-12.817-7. 004-1. 677 1.00 0.00 C ATOM 6423 C2'GUA 21-13.539-3. 996-0.092 1.00 0.00 C ATOM 6424 02'GUA 21-14.152-3. 198 0.928 1.00 0.00 0 ATOM 6425 C3'GUA 21-14. 056-3. 635-1.469 1.00 0.00 C ATOM 6426 03'GUA 21-14. 284-2.223-1. 529 1.00 0.00 0 ATOM 6427 1H5'GUA 21-16.806-5. 171-2.870 1.00 0.00 H ATOM 6428 2H5'GUA 21-16. 090-3.627-3. 377 1.00 0.00 H ATOM 6429 H4'GUA 21-16.131-3. 750-0.936 1.00 0.00 H ATOM 6430 H1'GUA 21-14.189-5. 697 1.052 1.00 0.00 H ATOM 6431 1H2 GUA 21-10.328-6. 132 3.700 1.00 0. 00 H ATOM 6432 2H2 GUA 21-9. 009-7.244 3.403 1.00 0.00 H ATOM 6433 H1 GUA 21-8.807-8. 369 1.500 1.00 0.00 H ATOM 6434 H8 GUA 21-13.541-6. 830-2.470 1.00 0.00 H ATOM 6435 H2'GUA 21-12. 451-3.917-0. 056 1.00 0.00 H ATOM 6436 H02'GUA 21-15.102-3. 306 0.843 1.00 0.00 H ATOM 6437 H3'GUA 21-13.395-3. 992-2.261 1.00 0.00 H ATOM 6438 P ADE 22-13. 106-1. 219-1.976 1.00 0.00 P ATOM 6439 01P ADE 22-13.708 0. 104-2. 258 1.00 0.00 0 ATOM 6440 02P ADE 22-12.286-1. 892-3. 008 1.00 0.00 0 ATOM 6441 05'ADE 22-12.225-1. 095-0.634 1.00 0.00 0 ATOM 6442 C5'ADE 22-12.809-0. 587 0.568 1.00 0.00 C ATOM 6443 C4'ADE 22-11.995-0. 976 1.799 1.00 0.00 C ATOM 6444 04'ADE 22-11.782-2. 392 1.865 1.00 0.00 0 ATOM 6445 C1'ADE 22-10.435-2. 652 2.306 1.00 0.00 C ATOM 6446 N9 ADE 22-9.623-3. 273 1.240 1.00 0.00 N ATOM 6447 C4 ADE 22-8.380-3. 839 1.392 1.00 0.00 C ATOM 6448 N3 ADE 22-7.694-3. 955 2.545 1.00 0.00 N ATOM 6449 C2 ADE 22-6.523-4. 547 2.352 1.00 0.00 C ATOM 6450 N1 ADE 22-6.026-4. 994 1.197 1.00 0.00 N ATOM 6451 C6 ADE 22-6.730-4. 866 0.058 1.00 0.00 C ATOM 6452 N6 ADE 22-6.215-5. 316-1.084 1.00 0.00 N ATOM 6453 C5 ADE 22-7.984-4. 255 0.143 1.00 0.00 C ATOM 6454 N7 ADE 22-8.963-3. 964-0.812 1.00 0.00 N ATOM 6455 C8 ADE 22-9.871-3. 399-0.089 1.00 0.00 C ATOM 6456 C2'ADE 22-9.858-1. 298 2.704 1.00 0.00 C ATOM 6457 02'ADE 22-10.137-0. 989 4.075 1.00 0.00 0 ATOM 6458 C3'ADE 22-10.601-0. 378 1.758 1.00 0.00 C ATOM 6459 03'ADE 22-10.642 0.935 2.327 1.00 0. 00 0 ATOM 6460 lH5'ADE 22-13.817-0. 988 0.670 1.00 0.00 H ATOM 6461 2H5'ADE 22-12. 863 0.500 0.506 1.00 0.00 H ATOM 6462 H4'ADE 22-12.510-0. 647 2.700 1.00 0.00 H ATOM 6463 H1'ADE 22-10.458-3. 308 3.177 1.00 0.00 H ATOM 6464 H2 ADE 22-5.898-4. 685 3.234 1. 00 0. 00 H

ATOM 6465 1H6 ADE 22-6.736-5. 224-1.945 1.00 0.00 H ATOM 6466 2H6 ADE 22-5.302-5. 750-1.091 1.00 0.00 H ATOM 6467 H8 ADE 22-10.798-3. 036-0.531 1.00 0.00 H ATOM 6468 H2'ADE 22-8.783-1. 269 2.502 1.00 0. 00 H ATOM 6469 H02'ADE 22-11.090-1. 018 4.186 1.00 0.00 H ATOM 6470 H3'ADE 22-10.175-0. 392 0. 754 1.00 0.00 H ATOM 6471 P CYT 23-9.415 1.957 2.112 1.00 0. 00 P ATOM 6472 01P CYT 23-9.777 3.251 2.733 1.00 0.00 O ATOM 6473 02P CYT 23-9.016 1.909 0.688 1.00 0.00 0 ATOM 6474 05'CYT 23-8.240 1.287 2.986 1.00 0.00 0 ATOM 6475 C5'CYT 23-8.324 1.252 4.414 1.00 0.00 C ATOM 6476 C4'CYT 23-7.122 0.542 5.032 1.00 0.00 C ATOM 6477 04'CYT 23-6. 993-0.796 4.547 1.00 0.00 0 ATOM 6478 C1'CYT 23-5.597-1. 131 4.424 1.00 0.00 C ATOM 6479 N1 CYT 23-5.258-1. 523 3.038 1.00 0.00 N ATOM 6480 C6 CYT 23-5.957-1. 028 1.975 1.00 0.00 C ATOM 6481 C2 CYT 23-4.207-2. 415 2.861 1.00 0. 00 C ATOM 6482 02 CYT 23-3.591-2. 849 3.833 1.00 0.00 0 ATOM 6483 N3 CYT 23-3.887-2. 791 1.593 1.00 0.00 N ATOM 6484 C4 CYT 23-4. 565-2.315 0.541 1.00 0.00 C ATOM 6485 N4 CYT 23-4.224-2. 706-0.686 1.00 0.00 N ATOM 6486 C5 CYT 23-5.647-1. 396 0.717 1.00 0. 00 C ATOM 6487 C2'CYT 23-4.810 0.109 4.853 1.00 0.00 C ATOM 6488 02'CYT 23-4.397 0.016 6.221 1.00 0.00 0 ATOM 6489 C3'CYT 23-5.823 1.222 4.647 1.00 0.00 C ATOM 6490 03'CYT 23-5.563 2.266 5.593 1.00 0.00 0 ATOM 6491 1H5'CYT 23-9.235 0.727 4.704 1.00 0.00 H ATOM 6492 2H5'CYT 23-8.366 2.274 4.793 1.00 0.00 H ATOM 6493 H4'CYT 23-7.221 0.525 6.116 1.00 0. 00 H ATOM 6494 H1'CYT 23-5.365-1. 955 5.099 1.00 0.00 H ATOM 6495 H6 CYT 23-6.770-0. 323 2.147 1.00 0.00 H ATOM 6496 1H4 CYT 23-4.728-2. 354-1.487 1.00 0.00 H ATOM 6497 2H4 CYT 23-3.461-3. 355-0.815 1.00 0.00 H ATOM 6498 H5 CYT 23-6.204-1. 012-0.137 1.00 0.00 H ATOM 6499 H2'CYT 23-3.952 0.253 4.193 1.00 0.00 H ATOM 6500 H02'CYT 23-3.632-0. 563 6.250 1.00 0.00 H ATOM 6501 H3'CYT 23-5.834 1.579 3.616 1.00 0.00 H ATOM 6502 P GUA 24-4.403 3.355 5.330 1.00 0.00 P ATOM 6503 01P GUA 24-4.250 3.529 3.868 1.00 0.00 0 ATOM 6504 02P GUA 24-4. 672 4.531 6.188 1.00 0.00 0 ATOM 6505 05'GUA 24-3.087 2.612 5.890 1.00 0.00 0 ATOM 6506 C5'GUA 24-2.967 2.289 7.279 1.00 0.00 C ATOM 6507 C4'GUA 24-1.654 1.569 7.579 1.00 0.00 C ATOM 6508 04'GUA 24-1.514 0.380 6.784 1.00 0.00 O ATOM 6509 C1'GUA 24-0. 225 0.375 6.149 1.00 0.00 C ATOM 6510 N9 GUA 24-0.331 0.720 4.717 1.00 0.00 N ATOM 6511 C4 GUA 24 0.639 0.540 3.760 1.00 0.00 C ATOM 6512 N3 GUA 24 1.875 0.036 3.973 1.00 0.00 N ATOM 6513 C2 GUA 24 2.596-0. 020 2.851 1.00 0.00 C ATOM 6514 N2 GUA 24 3.844-0. 486 2.886 1.00 0.00 N ATOM 6515 N1 GUA 24 2.127 0.390 1.618 1.00 0.00 N ATOM 6516 C6 GUA 24 0.864 0.910 1.375 1.00 0.00 C ATOM 6517 06 GUA 24 0.543 1.245 0.238 1.00 O-OID 0 ATOM 6518 C5 GUA 24 0.090 0.974 2.564 1.00 0.00 C ATOM 6519 N7 GUA 24-1.217 1.429 2.758 1.00 0. 00 N ATOM 6520 C8 GUA 24-1.372 1.245 4.026 1.00 0. 00 C ATOM 6521 C2'GUA 24 0.602 1.400 6.904 1.00 0.00 C ATOM 6522 02'GUA 24 1.177 0.840 8.091 1. 00 0. 00 0 ATOM 6523 C3'GUA 24-0.452 2.438 7.227 1. 00 0. 00 C ATOM 6524 03'GUA 24-0.046 3. 154 8.400 1.00 0. 00 O

ATOM 6525 1H5'GUA 24-3.799 1.644 7.566 1.00 0.00 H ATOM 6526 2H5'GUA 24-3.011 3.208 7.864 1.00 0.00 H ATOM 6527 H4'GUA 24-1. 616 1.302 8.635 1.00 0.00 H ATOM 6528 Hl'GUA 24 0. 234-0. 607 6.252 1.00 0.00 H ATOM 6529 1H2 GUA 24 4.243-0. 796 3.760 1.00 0.00 H ATOM 6530 2H2 GUA 24 4.392-0. 529 2.038 1.00 0.00 H ATOM 6531 H1 GUA 24 2.732 0.311 0.817 1.00 0.00 H ATOM 6532 H8 GUA 24-2.306 1.505 4. 523 1.00 0.00 H ATOM 6533 H2'GUA 24 1.369 1.819 6.253 1.00 0.00 H ATOM 6534 H02'GUA 24 1.562 1.565 8.589 1.00 0.00 H ATOM 6535 H3'GUA 24-0.652 3.096 6.380 1. 00 0.00 H ATOM 6536 P ADE 25 0.780 4. 532 8.277 1.00 0.00 P ATOM 6537 01P ADE 25 0.912 5.113 9.633 1.00 0.00 0 ATOM 6538 02P ADE 25 0.185 5.336 7.187 1.00 0.00 0 ATOM 6539 05'ADE 25 2.235 4. 033 7.798 1.00 0.00 0 ATOM 6540 C5'ADE 25 3.172 3.500 8.740 1.00 0.00 C ATOM 6541 C4'ADE 25 4.421 2. 958 8.048 1.00 0.00 C ATOM 6542 04'ADE 25 4.086 1.966 7.066 1.00 0.00 0 ATOM 6543 C1'ADE 25 4.820 2.219 5.854 1.00 0.00 C ATOM 6544 N9 ADE 25 3.935 2.727 4.786 1.00 0.00 N ATOM 6545 C4 ADE 25 4.188 2.709 3.434 1.00 0.00 C ATOM 6546 N3 ADE 25 5.296 2.231 2.834 1.00 0.00 N ATOM 6547 C2 ADE 25 5.225 2.363 1.514 1.00 0.00 C ATOM 6548 N1 ADE 25 4.221 2. 888 0.808 1.00 0.00 N ATOM 6549 C6 ADE 25 3.125 3.358 1.431 1.00 0.00 C ATOM 6550 N6 ADE 25 2.132 3.874 0.709 1.00 0.00 N ATOM 6551 C5 ADE 25 3.091 3.272 2.825 1.00 0.00 C ATOM 6552 N7 ADE 25 2.136 3.653 3.772 1.00 0.00 N ATOM 6553 C8 ADE 25 2.710 3.300 4.873 1.00 0.00 C ATOM 6554 C2'ADE 25 5.879 3.249 6.221 1.00 0.00 C ATOM 6555 02'ADE 25 7.059 2.629 6.746 1. 00 0.00 0 ATOM 6556 C3'ADE 25 5.149 4.051 7.278 1.00 0.00 C ATOM 6557 03'ADE 25 6.116 4.658 8.142 1.00 0.00 O ATOM 6558 1H5'ADE 25 2.697 2.693 9.297 1. 00 0.00 H ATOM 6559 2H5'ADE 25 3.464 4.287 9.435 1.00 0.00 H ATOM 6560 H4'ADE 25 5.090 2.522 8.787 1.00 0.00 H ATOM 6561 H1'ADE 25 5.304 1.300 5.522 1.00 0.00 H ATOM 6562 H2 ADE 25 6.082 2.004 0.944 1.00 0.00 H ATOM 6563 1H6 ADE 25 1.304 4.226 1.169 1.00 0.00 H ATOM 6564 2H6 ADE 25 2.205 3.912-0. 298 1.00 0.00 H ATOM 6565 H8 ADE 25 2.227 3.459 5.837 1.00 0.00 H ATOM 6566 H2'ADE 25 6.113 3.876 5.358 1.00 0.00 H ATOM 6567 H02'ADE 25 7.494 2.181 6.017 1.00 0.00 H ATOM 6568 H3'ADE 25 4.460 4. 776 6. 839 1.00 0.00 H ATOM 6569 P CYT 26 6.766 6.085 7.771 1.00 0.00 P ATOM 6570 01P CYT 26 5.668 7.036 7.486 1.00 0.00 0 ATOM 6571 02P CYT 26 7.777 6.414 8.801 1.00 0.00 0 ATOM 6572 05'CYT 26 7.534 5.777 6.387 1.00 0.00 0 ATOM 6573 C5'CYT 26 8.842 5.196 6.387 1.00 0.00 C ATOM 6574 C4'CYT 26 9.410 5.086 4.973 1.00 0.00 C ATOM 6575 04'CYT 26 8.607 4.231 4.143 1.00 0.00 0 ATOM 6576 C1'CYT 26 8.390 4.866 2.867 1.00 0.00 C ATOM 6577 N1 CYT 26 6.997 5.350 2.741 1.00 0.00 N ATOM 6578 C6 CYT 26 6. 325 5.829 3. 826 1.00 0.00 C ATOM 6579 C2 CYT 26 6.402 5.299 1.486 1.00 0.00 C ATOM 6580 02 CYT 26 7.026 4.863 0.520 1.00 0.00 0 ATOM 6581 N3 CYT 26 5.120 5.742 1.364 1.00 0.00 N ATOM 6582 C4 CYT 26 4.451 6. 214 2.423 1.00 0. 00 C ATOM 6583 N4 CYT 26 3.196 6.638 2.271 1.00 0. 00 N ATOM 6584 C5 CYT 26 5.062 6.268 3.713 1.00 0.00 C

ATOM 6585 C2'CYT 26 9.381 6. 019 2.814 1.00 0.00 C ATOM 6586 02'CYT 26 10.670 5.587 2.361 1.00 0.00 O ATOM 6587 C3'CYT 26 9.409 6.436 4.270 1.00 0.00 C ATOM 6588 03'CYT 26 10.650 7.096 4.542 1.00 0.00 0 ATOM 6589 1H5'CYT 26 8.790 4.200 6.828 1.00 0.00 H ATOM 6590 2H5'CYT 26 9.506 5.817 6.989 1.00 0.00 H ATOM 6591 H4'CYT 26 10.425 4.696 5.015 1.00 0.00 H ATOM 6592 Hl'CYT 26 8.608 4.162 2.066 1.00 0.00 H ATOM 6593 H6 CYT 26 6.818 5.855 4.797 1.00 0.00 H ATOM 6594 1H4 CYT 26 2.683 6.995 3.065 1.00 0.00 H ATOM 6595 2H4 CYT 26 2.757 6.603 1.362 1.00 0.00 H ATOM 6596 H5 CYT 26 4.530 6.664 4.574 1.00 0.00 H ATOM 6597 H2'CYT 26 8.991 6.824 2.187 1.00 0.00 H ATOM 6598 H02'CYT 26 11.286 6.304 2.529 1.00 0.00 H ATOM 6599 H3'CYT 26 8.541 7.040 4.539 1.00 0.00 H ATOM 6600 P CYT 27 10.692 8.426 5.454 1.00 0.00 P ATOM 6601 01P CYT 27 9.471 8.454 6.292 1.00 0.00 O ATOM 6602 02P CYT 27 12.025 8.508 6.090 1.00 0.00 0 ATOM 6603 05'CYT 27 10.580 9.606 4.361 1.00 0.00 0 ATOM 6604 C5'CYT 27 11.555 9.725 3.321 1.00 0.00 C ATOM 6605 C4'CYT 27 10.907 9.750 1.938 1.00 0.00 C ATOM 6606 04'CYT 27 9.925 8.720 1.798 1.00 0.00 0 ATOM 6607 C1'CYT 27 8.855 9.196 0.955 1.00 0.00 C ATOM 6608 N1 CYT 27 7.546 9.181 1.648 1.00 0.00 N ATOM 6609 C6 CYT 27 7.457 9.091 3.009 1.00 0.00 C ATOM 6610 C2 CYT 27 6.413 9.299 0.855 1.00 0.00 C ATOM 6611 02 CYT 27 6.518 9.387-0. 366 1.00 0.00 O ATOM 6612 N3 CYT 27 5.199 9.325 1.464 1.00 0.00 N ATOM 6613 C4 CYT 27 5.093 9.241 2.794 1.00 0.00 C ATOM 6614 N4 CYT 27 3.883 9.257 3.350 1.00 0.00 N ATOM 6615 C5 CYT 27 6.254 9.121 3.622 1.00 0.00 C ATOM 6616 C2'CYT 27 9.227 10.621 0.558 1.00 0.00 C ATOM 6617 02'CYT 27 9.909 10.655-0. 702 1.00 0.00 0 ATOM 6618 C3'CYT 27 10.134 11.033 1.699 1.00 0.00 C ATOM 6619 03'CYT 27 11.035 12.043 1.228 1.00 0.00 0 ATOM 6620 1H5'CYT 27 12.238 8.877 3.375 1.00 0.00 H ATOM 6621 2H5'CYT 27 12.121 10.646 3.466 1.00 0.00 H ATOM 6622 H4'CYT 27 11.668 9. 630' 1.170 1.00 0.00 H ATOM 6623 H1'CYT 27 8.799 8.575 0.060 1.00 0.00 H ATOM 6624 H6 CYT 27 8.364 8.979 3.603 1.00 0.00 H ATOM 6625 1H4 CYT 27 3.786 9.186 4.352 1.00 0.00 H ATOM 6626 2H4 CYT 27 3.062 9.338 2.765 1.00 0.00 H ATOM 6627 H5 CYT 27 6.168 9.074 4.710 1.00 0.00 H ATOM 6628 H2'CYT 27 8.335 11.250 0.538 1.00 0.00 H ATOM 6629 H02'CYT 27 10.147 11.569-0. 872 1.00 0.00 H ATOM 6630 H3'CYT 27 9.569 11.346 2.579 1.00 0.00 H ATOM 6631 P GUA 28 10.520 13.553 0.986 1.00 0.00 P ATOM 6632 01P GUA 28 11.705 14.425 0.821 1.00 0.00 0 ATOM 6633 02P GUA 28 9.511 13.871 2.023 1.00 0.00 0 ATOM 6634 05'GUA 28 9.763 13.451-0. 434 1.00 0.00 0 ATOM 6635 C5'GUA 28 10.472 13.669-1. 660 1.00 0.00 C ATOM 6636 C4'GUA 28 9.524 14.006-2. 810 1.00 0.00 C ATOM 6637 04'GUA 28 8.590 12.943-3. 057 1.00 0.00 0 ATOM 6638 Cl'GUA 28 7.265 13.490-3. 203 1.00 0.00 C ATOM 6639 N9 GUA 28 6.432 13.183-2. 022 1.00 0.00 N ATOM 6640 C4 GUA 28 5.055 13.161-1. 964 1.00 0.00 C ATOM 6641 N3 GUA 28 4.210 13.437-2. 984 1.00 0.00 N ATOM 6642 C2 GUA 28 2.927 13.333-2. 621 1.00 0.00 C ATOM 6643 N2 GUA 28 1.960 13. 584-3. 503 1.00 0.00 N ATOM 6644 N1 GUA 28 2.518 12.981-1. 350 1.00 0.00 N

ATOM 6645 C6 GUA 28 3.364 12.693-0. 288 1.00 0.00 C ATOM 6646 06 GUA 28 2.899 12.384 0.805 1.00 0.00 0 ATOM 6647 C5 GUA 28 4.729 12.803-0. 664 1.00 0.00 C ATOM 6648 N7 GUA 28 5.884 12.602 0.096 1.00 0.00 N ATOM 6649 C8 GUA 28 6.811 12.844-0. 767 1.00 0.00 C ATOM 6650 C2'GUA 28 7.458 14.990-3. 365 1.00 0.00 C ATOM 6651 02'GUA 28 7.720 15.344-4. 728 1.00 0.00 O ATOM 6652 C3'GUA 28 8.667 15.220-2. 483 1. 00 0. 00 C ATOM 6653 03'GUA 28 9.347 16.397-2. 931 1.00 0.00 O ATOM 6654 1H5'GUA 28 11.032 12.769-1. 913 1.00 0.00 H ATOM 6655 2H5'GUA 28 11.170 14.495-1. 524 1.00 0.00 H ATOM 6656 H4'GUA 28 10.099 14.197-3. 715 1.00 0.00 H ATOM 6657 H1'GUA 28 6.796 13.081-4. 099 1.00 0.00 H ATOM 6658 1H2 GUA 28 2.196 13.852-4. 448 1.00 0.00 H ATOM 6659 2H2 GUA 28 0.991 13.509-3. 227 1.00 0.00 H ATOM 6660 H1 GUA 28 1.529 12.922-1. 155 1.00 0.00 H ATOM 6661 H8 GUA 28 7.864 12.789-0. 495 1.00 0.00 H ATOM 6662 H2'GUA 28 6.590 15.528-2. 976 1.00 0.00 H ATOM 6663 H02'GUA 28 8.476 14.827-5. 017 1.00 0.00 H ATOM 6664 H3'GUA 28 8.400 15.263-1. 426 1.00 0.00 H ATOM 6665 P CYT 29 9.029 17.827-2. 263 1.00 0.00 P ATOM 6666 O1P CYT 29 9. 854 18.850-2. 943 1.00 0.00 0 ATOM 6667 02P CYT 29 9.102 17.678-0. 792 1.00 0.00 0 ATOM 6668 05'CYT 29 7.489 18.068-2. 667 1.00 0.00 0 ATOM 6669 C5'CYT 29 7.134 18.448-4. 000 1.00 0.00 C ATOM 6670 C4'CYT 29 5.620 18.478-4. 191 1. 00 0.00 C ATOM 6671 04'CYT 29 5.034 17.188-3. 965 1. 00 0.00 0 ATOM 6672 C1'CYT 29 3.838 17.331-3. 175 1.00 0.00 C ATOM 6673 N1 CYT 29 4.018 16.764-1. 819 1.00 0.00 N ATOM 6674 C6 CYT 29 5.252 16.711-1. 235 1.00 0.00 C ATOM 6675 C2 CYT 29, 2.891 16.274-1. 172 1.00 0.00 C ATOM 6676 02 CYT 29 1.789 16.340-1. 713 1.00 0.00 0 ATOM 6677 N3 CYT 29 3.043 15.729 0.065 1.00 0.00 N ATOM 6678 C4 CYT 29 4.247 15.668 0.647 1.00 0.00 C ATOM 6679 N4 CYT 29 4.362 15.115 1.854 1.00 0.00 N ATOM 6680 C5 CYT 29 5.410 16.174-0. 011 1.00 0.00 C ATOM 6681 C2'CYT 29 3. 554 18. 827-3. 117 1.00 0.00 C ATOM 6682 02'CYT 29 2.758 19.255-4. 228 1.00 0.00 0 ATOM 6683 C3'CYT 29 4.955 19.397-3. 178 1.00 0.00 C ATOM 6684 03'CYT 29 4.894 20.716-3. 728 1. 00 0.00 0 ATOM 6685 1H5'CYT 29 7.567 17.736-4. 702 1.00 0.00 H ATOM 6686 2H5'CYT 29 7.537 19.440-4. 206 1.00 0.00 H ATOM 6687 H4'CYT 29 5.382 18.811-5. 200 1. 00 0.00 H ATOM 6688 H1'CYT 29 3.012 16.824-3. 675 1.00 0.00 H ATOM 6689 H6 CYT 29 6.117 17.111-1. 763 1.00 0.00 H ATOM 6690 1H4 CYT 29 5.267 15.056 2.298 1.00 0.00 H ATOM 6691 2H4 CYT 29 3.544 14.758 2.326 1.00 0. 00 H ATOM 6692 H5 CYT 29 6.391 16.126 0.461 1.00 0. 00 H ATOM 6693 H2'CYT 29 3.077 19.085-2. 168 1.00 0.00 H ATOM 6694 H02'CYT 29 3.216 18.986-5. 028 1.00 0. 00 H ATOM 6695 H3'CYT 29 5.452 19.368-2. 207 1.00 0.00 H ATOM 6696 P CYT 30 4.816 22.002-2. 761 1.00 0.00 P ATOM 6697 O1P CYT 30 5.844 21.851-1. 706 1.00 0.00 O ATOM 6698 02P CYT 30 4.800 23.216-3. 607 1.00 0.00 O ATOM 6699 05'CYT 30 3.367 21.841-2. 079 1.00 0.00 O ATOM 6700 C5'CYT 30 2.176 22.117-2. 822 1.00 0.00 C ATOM 6701 C4'CYT 30 0.927 21.669-2. 068 1.00 0.00 C ATOM 6702 04'CYT 30 0.958 20.269-1. 778 1.00 0.00 0 ATOM 6703 C1'CYT 30 0.362 20.040-0. 489 1.00 0.00 c ATOM 6704 N1 CYT 30 1.331 19.444 0.458 1. 00 0.00 N

ATOM 6705 C6 CYT 30 2.676 19.625 0.303 1.00 0.00 C ATOM 6706 C2 CYT 30 0.820 18.685 1. 502 1.00 0.00 C ATOM 6707 02 CYT 30-0.396 18.546 1.629 1.00 0.00 0 ATOM 6708 N3 CYT 30 1.693 18.117 2.376 1.00 0.00 N ATOM 6709 C4 CYT 30 3.014 18.285 2.237 1.00 0.00 C ATOM 6710 N4 CYT 30 3.839 17.712 3.112 1.00 0.00 N ATOM 6711 C5 CYT 30 3.548 19.066 1.165 1.00 0.00 C ATOM 6712 C2'CYT 30-0.123 21.404 0.001 1.00 0.00 C ATOM 6713 02'CYT 30-1.484 21.643-0. 382 1.00 0.00 0 ATOM 6714 C3'CYT 30 0.827 22.343-0. 712 1.00 0. 00 C ATOM 6715 03'CYT 30 0.296 23.670-0. 810 1.00 0.00 0 ATOM 6716 1H5'CYT 30 2.222 21.592-3. 777 1.00 0.00 H ATOM 6717 2H5'CYT 30 2.113 23.189-3. 009 1.00 0.00 H ATOM 6718 H4'CYT 30 0. 040 21.896-2. 657 1.00 0.00 H ATOM 6719 Hl'CYT 30-0.493 19.373-0. 602 1.00 0.00 H ATOM 6720 H6 CYT 30 3.048 20.234-0. 521 1.00 0.00 H ATOM 6721 1H4 CYT 30 4. 838 17.830 3.017 1.00 0.00 H ATOM 6722 2H4 CYT 30 3.466 17.165 3.875 1.00 0.00 H ATOM 6723 H5 CYT 30 4.623 19.204 1.048 1.00 0.00 H ATOM 6724 H2'CYT 30 0. 001 21.485 1.084 1.00 0.00 H ATOM 6725 H02'CYT 30-2.026 20.997 0.077 1.00 0.00 H ATOM 6726 H3'CYT 30 1.801 22.340-0. 215 1.00 0.00 H ATOM 6727 H03'CYT 30-0.611 23.591-1. 116 1.00 0.00 H TER ATOM 6728 05'GUA 1 0.156 13.589-13. 799 1.00 0.00 0 ATOM 6729 C5'GUA 1-0.058 14.672-14. 708 1.00 0.00 C ATOM 6730 C4'GUA 1-0.981 14.270-15. 856 1.00 0.00 C ATOM 6731 04'GUA 1-0.438 13.173-16. 609 1.00 0.00 0 ATOM 6732 C1'GUA 1-1.455 12.174-16. 803 1.00 0.00 C ATOM 6733 N9 GUA 1-1.226 11.003-15. 931 1.00 0.00 N ATOM 6734 C4 GUA 1-1.597 9.701-16. 186 1.00 0.00 C ATOM 6735 N3 GUA 1-2.251 9.262-17. 286 1.00 0.00 N ATOM 6736 C2 GUA 1-2.471 7.944-17. 249 1.00 0.00 C ATOM 6737 N2 GUA 1-3.111 7.347-18. 254 1.00 0.00 N ATOM 6738 N1 GUA 1-2.074 7.130-16. 207 1.00 0.00 N ATOM 6739 C6 GUA 1-1.403 7.557-15. 069 1.00 0.00 C ATOM 6740 06 GUA 1-1.096 6.750-14. 195 1.00 0.00 O ATOM 6741 C5 GUA 1-1.166 8.956-15. 099 1.00 0.00 C ATOM 6742 N7 GUA 1-0.529 9.775-14. 162 1.00 0.00 N ATOM 6743 C8 GUA 1-0.612 10.932-14. 725 1.00 0.00 C ATOM 6744 C2'GUA 1-2.767 12.861-16. 463 1.00 0.00 C ATOM 6745 02'GUA 1-3. 279 13.600-17. 579 1.00 0.00 0 ATOM 6746 C3'GUA 1-2.324 13.774-15. 339 1.00 0.00 C ATOM 6747 03'GUA 1-3.227 14.881-15. 260 1.00 0.00 0 ATOM 6748 H5'GUA 1-0.680 13.413-13. 362 1.00 0.00 H ATOM 6749 1H5'GUA 1 0.901 14.988-15. 117 1.00 0. 00 H ATOM 6750 2H5'GUA 1-0.506 15.505-14. 166 1.00 0.00 H ATOM 6751 H4'GUA 1-1.135 15.120-16. 519 1.00 0.00 H ATOM 6752 H1'GUA 1-1.465 11.859-17. 847 1.00 0.00 H ATOM 6753 1H2 GUA 1-3.431 7.890-19. 043 1.00 0.00 H ATOM 6754 2H2 GUA 1-3.271 6.350-18. 230 1.00 0.00 H ATOM 6755 H1 GUA 1-2.272 6.142-16. 258 1.00 0. 00 H ATOM 6756 H8 GUA 1-0.207 11.822-14. 245 1.00 0.00 H ATOM 6757 H2'GUA 1-3.496 12.132-16. 103 1.00 0. 00 H ATOM 6758 H02'GUA 1-3. 642 12.964-18. 199 1.00 0.00 H ATOM 6759 H3'GUA 1-2.229 13.239-14. 393 1.00 0.00 H ATOM 6760 P GUA 2-4.559 14.786-14. 359 1.00 0.00 P ATOM 6761 01P GUA 2-5.279 16.075-14. 458 1.00 0. 00 0 ATOM 6762 02P GUA 2-4.183 14.251-13. 030 1.00 0.00 0 ATOM 6763 05'GUA 2-5.423 13. 663-15. 126 1.00 0.00 0

ATOM 6764 C5'GUA 2-6. 003 13.940-16. 404 1.00 0.00 C ATOM 6765 C4'GUA 2-6.514 12.670-17. 079 1.00 0.00 C ATOM 6766 04'GUA 2-5.472 11.703-17. 252 1.00 0.00 0 ATOM 6767 C1'GUA 2-5.991 10.384-16. 989 1.00 0.00 C ATOM 6768 N9 GUA 2-5.352 9.781-15. 800 1.00 0. 00 N ATOM 6769 C4 GUA 2-5.220 8.436-15. 532 1.00 0.00 C ATOM 6770 N3 GUA 2-5.667 7.425-16. 312 1.00 0.00 N ATOM 6771 C2 GUA 2-5.391 6.225-15. 791 1.00 0.00 C ATOM 6772 N2 GUA 2-5.766 5.118-16. 434 1.00 0.00 N ATOM 6773 N1 GUA 2-4.726 6.043-14. 595 1.00 0.00 N ATOM 6774 C6 GUA 2-4.259 7.063-13. 778 1.00 0.00 C ATOM 6775 06 GUA 2-3.675 6.795-12. 730 1.00 0.00 0 ATOM 6776 C5 GUA 2-4.548 8.343-14. 323 1.00 0.00 C ATOM 6777 N7 GUA 2-4.255 9.616-13. 824 1.00 0.00 N ATOM 6778 C8 GUA 2-4.754 10.379-14. 737 1.00 0.00 C ATOM 6779 C2'GUA 2-7.493 10.558-16. 778 1.00 0.00 C ATOM 6780 02'GUA 2-8.214 10. 441-18. 010 1 : 00 0.00 O ATOM 6781 C3'GUA 2-7.554 11.967-16. 225 1.00 0.00 C ATOM 6782 03'GUA 2-8.839 12. 526-16.515 1.00 0.00 O ATOM 6783 1H5'GUA 2-5.252 14.404-17. 044 1.00 0.00 H ATOM 6784 2H5'GUA 2-6.835 14.632-16. 273 1.00 0.00 H ATOM 6785 H4'GUA 2-6.942 12.916-18. 049 1.00 0.00 H ATOM 6786 H1'GUA 2-5. 819 9.748-17. 857 1.00 0.00 H ATOM 6787 1H2 GUA 2-6.259 5.187-17. 313 1.00 0.00 H ATOM 6788 2H2 GUA 2-5.555 4.211-16. 043 1.00 0.00 H ATOM 6789 H1 GUA 2-4.551 5.102-14. 272 1.00 0.00 H ATOM 6790 H8 GUA 2-4.698 11.464-14. 657 1.00 0.00 H ATOM 6791 H2'GUA 2-7.856 9.842-16. 038 1.00 0.00 H ATOM 6792 H02'GUA 2-7.851 11.091-18. 616 1.00 0.00 H ATOM 6793 H3'GUA 2-7.308 12.001-15. 162 1.00 0.00 H ATOM 6794 P CYT 3-10.054 12.364-15. 471 1.00 0.00 P ATOM 6795 01P CYT 3-9.517 12.536-14. 103 1.00 0.00 O ATOM 6796 02P CYT 3-11. 178 13. 208-15.933 1.00 0.00 O ATOM 6797 05'CYT 3-10.471 10.819-15. 657 1.00 0.00 O ATOM 6798 C5'CYT 3-11.289 10.412-16. 758 1.00 0.00 C ATOM 6799 C4'CYT 3-11.566 8.911-16. 726 1.00 0.00 C ATOM 6800 04'CYT 3-10.362 8.144-16. 878 1.00 0.00 O ATOM 6801 Cl'CYT 3-10.359 7.061-15. 927 1.00 0.00 C ATOM 6802 N1 CYT 3-9.359 7.289-14. 858 1.00 0.00 N ATOM 6803 C6 CYT 3-9.107 8.547-14. 391 1.00 0.00 C ATOM 6804 C2 CYT 3-8.691 6.182-14. 350 1.00 0.00 C ATOM 6805 02 CYT 3-8.938 5.056-14. 782 1.00 0.00 O ATOM 6806 N3 CYT 3-7.769 6.379-13. 368 1.00 0.00 N ATOM 6807 C4 CYT 3-7.513 7.609-12. 902 1.00 0.00 C ATOM 6808 N4 CYT 3-6.600 7.768-11. 945 1.00 0.00 N ATOM 6809 C5 CYT 3-8.200 8.750-13. 421 1.00 0.00 C ATOM 6810 C2'CYT 3-11.771 7.015-15. 356 1.00 0.00 C ATOM 6811 02'CYT 3-12.647 6.234-16. 179 1.00 0.00 0 ATOM 6812 C3'CYT 3-12.135 8.484-15. 383 1.00 0.00 C ATOM 6813 03'CYT 3-13.559 8.613-15. 421 1.00 0.00 O ATOM 6814 1H5'CYT 3-10.784 10.661-17. 691 1. 00 0.00 H ATOM 6815 2H5'CYT 3-12.237 10.948-16. 712 1.00 0.00 H ATOM 6816 H4'CYT 3-12.264 8.648-17. 520 1.00 0.00 H ATOM 6817 H1'CYT 3-10.141 6.124-16. 440 1.00 0.00 H ATOM 6818 H6 CYT 3-9.642 9.397-14. 812 1. 00 0.00 H ATOM 6819 1H4 CYT 3-6.396 8.692-11. 590 1.00 0.00 H ATOM 6820 2H4 CYT 3-6.113 6.965-11. 573 1., 00 0.00 H ATOM 6821 H5 CYT 3-8.001 9.751-13. 040 1.00 0.00 H ATOM 6822 H2'CYT 3-11.754 6.641-14. 331 1. 00 0. 00 H ATOM 6823 H02'CYT 3-12. 403 5.313-16. 063 1. 00 0.00 H

ATOM 6824 H3'CYT 3-11.683 9.031-14. 552 1.00 0.00 H ATOM 6825 P GUA 4-14.383 8.935-14. 076 1.00 0. 00 P ATOM 6826 O1P GUA 4-13.652 9.979-13. 323 1.00 0.00 0 ATOM 6827 02P GUA 4-15.802 9.146-14. 441 1.00 0.00 0 ATOM 6828 05'GUA 4-14.270 7.553-13. 258 1.00 0.00 0 ATOM 6829 C5'GUA 4-15.034 6.410-13. 654 1.00 0.00 C ATOM 6830 C4'GUA 4-14.537 5.135-12. 979 1.00 0.00 C ATOM 6831 04'GUA 4-13.166 4.865-13. 296 1.00 0.00 0 ATOM 6832 C1'GUA 4-12.505 4.330-12. 131 1.00 0.00 C ATOM 6833 N9 GUA 4-11.441 5.233-11. 649 1.00 0.00 N ATOM 6834 C4 GUA 4-10.381 4.887-10. 843 1.00 0.00 C ATOM 6835 N3 GUA 4-10.119 3.648-10. 369 1.00 0.00 N ATOM 6836 C2 GUA 4-9.023 3.621-9. 607 1.00 0.00 C ATOM 6837 N2 GUA 4-8.625 2.476-9. 054 1.00 0.00 N ATOM 6838 N1 GUA 4-8.249 4.734-9. 340 1.00 0.00 N ATOM 6839 C6 GUA 4-8.497 6.014-9. 817 1.00 0.00 C ATOM 6840 06 GUA 4-7.742 6.937-9. 525 1.00 0.00 0 ATOM 6841 C5 GUA 4-9.662 6. 051-10. 626 1.00 0.00 C ATOM 6842 N7 GUA 4-10.258 7.129-11. 289 1.00 0.00 N ATOM 6843 C8 GUA 4-11.273 6.564-11. 849 1.00 0.00 C ATOM 6844 C2'GUA 4-13.590 4.163-11. 071 1.00 0.00 C ATOM 6845 02'GUA 4-14.197 2.867-11. 140 1.00 0.00 0 ATOM 6846 C3'GUA 4-14.557 5. 258-11. 467 1.00 0.00 C ATOM 6847 03'GUA 4-15.862 4.919-10. 987 1.00 0.00 0 ATOM 6848 1H5'GUA 4-14. 962 6.291-14. 735 1. 00 0.00 H ATOM 6849 2H5'GUA 4-16.078 6.571-13. 383 1.00 0.00 H ATOM 6850 H4'GUA 4-15.151 4.291-13. 288 1.00 0.00 H ATOM 6851 H1'GUA 4-12.077 3.356-12. 370 1.00 0.00 H ATOM 6852 1H2 GUA 4-9. 152 1.629-9. 213 1.00 0.00 H ATOM 6853 2H2 GUA 4-7.803 2.456-8. 469 1.00 0.00 H ATOM 6854 H1 GUA 4-7.440 4.634-8. 744 1.00 0.00 H ATOM 6855 H8 GUA 4-11.976 7.138-12. 453 1.00 0.00 H ATOM 6856 H2'GUA 4-13.181 4.356-10. 076 1. 00 0.00 H ATOM 6857 H02'GUA 4-14.520 2.750-12. 036 1.00 0.00 H ATOM 6858 H3'GUA 4-14.224 6.241-11. 129 1.00 0.00 H ATOM 6859 P CYT 5-16. 274 5.234-9. 462 1.00 0.00 P ATOM 6860 01P CYT 5-17.714 4.934-9. 300 1.00 0.00 0 ATOM 6861 02P CYT 5-15.756 6.575-9. 108 1.00 0.00 0 ATOM 6862 05'CYT 5-15.432 4.137-8. 637 1.00 0.00 0 ATOM 6863 C5'CYT 5-15.813 2.759-8. 662 1.00 0.00 C ATOM 6864 C4'CYT 5-14.902 1.908-7. 782 1.00 0.00 C ATOM 6865 04'CYT 5-13.545 1.941-8. 235 1.00 0.00 0 ATOM 6866 C1'CYT 5-12.660 1.963-7. 098 1.00 0.00 C ATOM 6867 N1 CYT 5-11. 853. 3.205-7. 071 1.00 0.00 N ATOM 6868 C6 CYT 5-12.374 4.393-7. 500 1.00 0.00 C ATOM 6869 C2 CYT 5-10. 549 3.115-6. 599 1.00 0.00 C ATOM 6870 02 CYT 5-10.101 2.035-6. 218 1.00 0.00 0 ATOM 6871 N3 CYT 5-9.793 4.247-6. 572 1.00 0.00 N ATOM 6872 C4 CYT 5-10.290 5.417-6. 990 1.00 0.00 C ATOM 6873 N4 CYT 5-9.519 6.504-6. 952 1.00 0.00 N ATOM 6874 C5 CYT 5-11. 631 5.517-7. 477 1.00 0.00 C ATOM 6875 C2'CYT 5-13.550 1.852-5. 860 1.00 0.00 C ATOM 6876 02'CYT 5-13.713 0.488-5. 454 1.00 0.00 0 ATOM 6877 C3'CYT 5-14.851 2.445-6. 364 1.00 0. 00 C ATOM 6878 03'CYT 5-15.940 1. 881-5. 626 1.00 0.00 O ATOM 6879 1H5'CYT 5-15.760 2.392-9. 687 1.00 0.00 H ATOM 6880 2H5'CYT 5-16.839 2.668-8. 304 1.00 0.00 H ATOM 6881 H4'CYT 5-15.255 0.878-7. 773 1.00 0.00 H ATOM 6882 Hl'CYT 5-11.995 1.100-7. 143 1.00 0.00 H ATOM 6883 H6 CYT 5-13.400 4.433-7. 864 1. 00 0. 00 H

ATOM 6884 1H4 CYT 5-8.571 6.438-6. 609 1.00 0.00 H ATOM 6885 2H4 CYT 5-9.881 7. 392-7. 268 1.00 0.00 H ATOM 6886 H5 CYT 5-12.039 6.469-7. 817 1.00 0.00 H ATOM 6887 H2'CYT 5-13.144 2.459-5. 047 1.00 0.00 H ATOM 6888 H02'CYT 5-14.416 0.467-4. 800 1.00 0.00 H ATOM 6889 H3'CYT 5-14.842 3.535-6. 336 1.00 0.00 H ATOM 6890 P URI 6-16.678 2.729-4. 472 1.00 0. 00 P ATOM 6891 01P URI 6-16.613 4.164-4. 834 1.00 0.00 0 ATOM 6892 02P URI 6-17.988 2.096-4. 198 1.00 0.00 0 ATOM 6893 05'URI 6-15.724 2.487-3. 200 1.00 0.00 0 ATOM 6894 C5'URI 6-15.581 1.178-2. 640 1.00 0.00 C ATOM 6895 C4'URI 6-14.338 1.077-1. 761 1.00 0.00 C ATOM 6896 04'URI 6-13.148 1.424-2. 484 1.00 0.00 0 ATOM 6897 C1'URI 6-12.311 2.256-1. 656 1.00 0.00 C ATOM 6898 N1 URI 6-12.252 3.646-2. 166 1.00 0.00 N ATOM 6899 C6 URI 6-13.213 4.130-3. 013 1.00 0.00 C ATOM 6900 C2 URI 6-11.187 4.432-1. 759 1.00 0.00 C ATOM 6901 02 URI 6-10.319 4.017-0. 994 1.00 0.00 0 ATOM 6902 N3 URI 6-11.156 5.720-2. 261 1.00 0.00 N ATOM 6903 C4 URI 6-12.082 6.285-3. 120 1.00 0.00 C ATOM 6904 04 URI 6-11.952 7.444-3. 506 1.00 0.00 0 ATOM 6905 C5 URI 6-13.160 5.397-3. 491 1.00 0.00 C ATOM 6906 C2'URI 6-12.928 2.205-0. 265 1.00 0.00 C ATOM 6907 02'URI 6-12.446 1.082 0.483 1.00 0.00 0 ATOM 6908 C3'URI 6-14.396 2.062-0. 607 1.00 0.00 C ATOM 6909 03'URI 6-15.073 1.444 0.493 1.00 0.00 0 ATOM 6910 1H5'URI 6-15.505 0.451-3. 448 1.00 0.00 H ATOM 6911 2H5'URI 6-16.461 0.951-2. 039 1.00 0.00 H ATOM 6912 H4'URI 6-14.243 0.063-1. 375 1.00 0.00 H ATOM 6913 H1'URI 6-11.305 1.839-1. 620 1.00 0.00 H ATOM 6914 H6 URI 6-14.040 3.484-3. 309 1.00 0.00 H ATOM 6915 H3 URI 6-10.384 6.304-1. 973 1.00 0.00 H ATOM 6916 H5 URI 6-13.941 5.751-4. 164 1.00 0.00 H ATOM 6917 H2'URI 6-12.745 3.140 0. 266 1.00 0.00 H ATOM 6918 H02'URI 6-11.545 1.282 0.749 1.00 0.00 H ATOM 6919 H3'URI 6-14.843 3.014-0. 898 1.00 0.00 H ATOM 6920 P CYT 7-15.778 2.343 1.629 1.00 0. 00 P ATOM 6921 01P CYT 7-16.436 1.436 2.596 1.00 0.00 0 ATOM 6922 02P CYT 7-16.563 3.405 0.961 1.00 0.00 0 ATOM 6923 05'CYT 7-14.520 3.033 2.360 1.00 0.00 0 ATOM 6924 C5'CYT 7-13.514 2.231 2.985 1.00 0.00 C ATOM 6925 C4'CYT 7-12.240 3.029 3.250 1.00 0.00 C ATOM 6926 04'CYT 7-11.755 3.666 2.. 060 1.00 0.00 0 ATOM 6927 C1'CYT 7-11. 260 4.981 2.390 1.00 0.00 C ATOM 6928 N1 CYT 7-12.077 6.049 1.765 1.00 0.00 N ATOM 6929 C6 CYT 7-13.195 5.756 1.038 1.00 0.00 C ATOM 6930 C2 CYT 7-11.658 7.361 1.948 1.00 0.00 C ATOM 6931 02 CYT 7-10.652 7.602 2.610 1.00 0.00 O ATOM 6932 N3 CYT 7-12.389 8.358 1.382 1.00 0.00 N ATOM 6933 C4 CYT 7-13.486 8.085 0.665 1.00 0.00 C ATOM 6934 N4 CYT 7-14.178 9.089 0.129 1.00 0.00 N ATOM 6935 C5 CYT 7-13.923 6.736 0.473 1.00 0.00 C ATOM 6936 C2'CYT 7-11.315 5.076 3.911 1.00 0. 00 C ATOM 6937 02'CYT 7-10.106 4.597 4.512 1.00 0.00 0 ATOM 6938 C3'CYT 7-12.489 4.172 4.216 1.00 0.00 C ATOM 6939 03'CYT 7-12.360 3. 688 5.555 1.00 0.00 0 ATOM 6940 1H5'CYT 7-13.275 1.389 2.335 1.00 0.00 H ATOM 6941 2H5'CYT 7-13.899 1.851 3.932 1.00 0.00 H ATOM 6942 H4'CYT 7-11.468 2.372 3. 647 1.00 0.00 H ATOM 6943 H1'CYT 7-10.226 5.073 2.057 1.00 0.00 H

ATOM 6944 H6 CYT 7-13.507 4.720 0.922 1.00 0.00 H ATOM 6945 1H4 CYT 7-15.009 8.897-0. 412 1.00 0.00 H ATOM 6946 2H4 CYT 7-13.872 10.042 0.265 1.00 0.00 H ATOM 6947 H5 CYT 7-14.811 6. 509-0. 117 1.00 0.00 H ATOM 6948 H2'CYT 7-11.531 6.102 4.220 1.00 0. 00 H ATOM 6949 H02'CYT 7-9.423 5.248 4.336 1.00 0.00 H ATOM 6950 H3'CYT 7-13.445 4.666 4.033 1.00 0.00 H ATOM 6951 P ADE 8-13.051 4.483 6.772 1.00 0.00 P ATOM 6952 O1P ADE 8-14.498 4.596 6.485 1.00 0.00 0 ATOM 6953 02P ADE 8-12.597 3.873 8.043 1. 00 0.00 0 ATOM 6954 05'ADE 8-12.395 5.949 6.650 1. 00 0.00 0 ATOM 6955 C5'ADE 8-11. 044 6.180 7.060 1.00 0.00 C ATOM 6956 C4'ADE 8-10.690 7.665 7.022 1.00 0.00 C ATOM 6957 04'ADE 8-10.722 8.189 5.685 1.00 0.00 0 ATOM 6958 C1'ADE 8-11.420 9.451 5.684 1.00 0.00 C ATOM 6959 N9 ADE 8-12. 750 9.324 5.050 1.00 0.00 N ATOM 6960 C4 ADE 8-13.567 10.350 4.618 1.00 0.00 C ATOM 6961 N3 ADE 8-13.311 11.673 4.700 1.00 0.00 N ATOM 6962 C2 ADE 8-14.309 12.392 4.189 1.00 0.00 C ATOM 6963 N1 ADE 8-15.441 11.933 3.653 1. 00 0.00 N ATOM 6964 C6 ADE 8-15. 673 10.611 3.583 1. 00 0.00 C ATOM 6965 N6 ADE 8-16. 810 10.173 3.042 1.00 0.00 N ATOM 6966 C5 ADE 8-14.691 9.755 4.090 1.00 0.00 C ATOM 6967 N7 ADE 8-14.605 8.362 4. 178 1.00 0.00 N ATOM 6968 C8 ADE 8-13.456 8.207 4.744 1.00 0.00 C ATOM 6969 C2'ADE 8-11.540 9.850 7.146 1.00 0.00 C ATOM 6970 02'ADE 8-10.359 10.515 7.610 1.00 0.00 O ATOM 6971 C3'ADE 8-11. 709 8.492 7.788 1.00 0.00 C ATOM 6972 03'ADE 8-11.319 8.568 9.163 1.00 0.00 0 ATOM 6973 1H5'ADE 8-10.371 5.637 6.396 1.00 0.00 H ATOM 6974 2H5'ADE 8-10.914 5.811 8.077 1.00 0.00 H ATOM 6975 H4'ADE 8-9.699 7.818 7.446 1.00 0.00 H ATOM 6976 H1'ADE 8-10.831 10.194 5.153 1.00 0.00 H ATOM 6977 H2 ADE 8-14. 190 13.478 4.211 1.00 0.00 H ATOM 6978 1H6 ADE 8-17.488 10.833 2.690 1.00 0.00 H ATOM 6979 2H6 ADE 8-16.993 9.182 2.983 1. 00 0.00 H ATOM 6980 H8 ADE 8-13.070 7.214 4.973 1.00 0.00 H ATOM 6981 H2'ADE 8-12.429 10.464 7. 301 1.00 0.00 H ATOM 6982 H02'ADE 8-10.407 10.545 8.569 1.00 0.00 H ATOM 6983 H3'ADE 8-12.719 8.110 7.660 1.00 0.00 H ATOM 6984 P ADE 9-11.916 7.525 10.239 1.00 0.00 P ATOM 6985 O1P ADE 9-11.866 8.160 11.574 1.00 0.00 0 ATOM 6986 02P ADE 9-11.267 6.212 10.022 1.00 0.00 0 ATOM 6987 05'ADE 9-13.463 7.404 9.796 1.00 0.00 O ATOM 6988 C5'ADE 9-14.390 6.637 10.575 1.00 0.00 C ATOM 6989 C4'ADE 9-15.803 6.666 9.984 1.00 0.00 C ATOM 6990 04'ADE 9-16.271 8.007 9.813 1.00 0.00 0 ATOM 6991 C1'ADE 9-16.218 8.371 8.422 1.00 0.00 C ATOM 6992 N9 ADE 9-15.514 9.656 8.248 1.00 0.00 N ATOM 6993 C4 ADE 9-15.974 10.767 7.580 1.00 0.00 C ATOM 6994 N3 ADE 9-17.152 10.882 6.941 1.00 0.00 N ATOM 6995 C2 ADE 9-17.290 12.087 6.402 1.00 0.00 C ATOM 6996 N1 ADE 9-16.421 13.098 6.446 1.00 0.00 N ATOM 6997 C6 ADE 9-15.251 12.958 7.091 1.00 0. 00 C ATOM 6998 N6 ADE 9-14.394 13.979 7.124 1.00 0.00 N ATOM 6999 C5 ADE 9-14.997 11.727 7.700 1.00 0.00 C ATOM 7000 N7 ADE 9-13. 914 11.244 8.437 1.00 0.00 N ATOM 7001 C8 ADE 9-14.302 10. 044 8.708 1. 00 0. 00 C ATOM 7002 C2'ADE 9-15.484 7.235 7.713 1.00 0.00 C ATOM 7003 02'ADE 9-15.950 7.061 6. 369 1.00 0.00 0

ATOM 7004 C3'ADE 9-15.842 6.050 8.588 1. 00 0.00 C ATOM 7005 03'ADE 9-17.189 5.659 8.269 1.00 0.00 0 ATOM 7006 1H5'ADE 9-14.423 7.044 11.586 1.00 0.00 H ATOM 7007 2H5'ADE 9-14.046 5. 603 10.621 1.00 0.00 H ATOM 7008 H4'ADE 9-16.481 6.131 10.645 1.00 0.00 H ATOM 7009 Hl'ADE 9-17.230 8.453 8.026 1.00 0.00 H ATOM 7010 H2 ADE 9-18.220 12.272 5.873 1.00 0.00 H ATOM 7011 1H6 ADE 9-13.512 13.881 7.606 1.00 0.00 H ATOM 7012 2H6 ADE 9-14.627 14.849 6.668 1.00 0.00 H ATOM 7013 H8 ADE 9-13.676 9.368 9.283 1.00 0.00 H ATOM 7014 H2'ADE 9-14.408 7.404 7.740 1.00 0.00 H ATOM 7015 H02'ADE 9-16.897 6.910 6.413 1.00 0.00 H ATOM 7016 H3'ADE 9-15.133 5.229 8.481 1.00 0.00 H ATOM 7017 P URI 10-18.102 4.825 9.306 1.00 0.00 P ATOM 7018 O1P URI 10-17.226 3.904 10.064 1.00 0.00 O ATOM 7019 02P URI 10-19. 272 4.296 8.570 1.00 0.00 0 ATOM 7020. 05'URI 10-18.610 5.979 10.307 1.00 0.00 O ATOM 7021 C5'URI 10-19.923 5.947 10.871 1.00 0.00 C ATOM 7022 C4'URI 10-20.724 7.182 10.468 1.00 0.00 C ATOM 7023 04'URI 10-21.019 7.177 9.061 1.00 0.00 O ATOM 7024 C1'URI 10-22.439 7.064 8.861 1.00 0.00 C ATOM 7025 N1 URI 10-22.759 6.143 7.744 1.00 0.00 N ATOM 7026 C6 URI 10-21. 800 5.326 7.204 1.00 0.00 C ATOM 7027 C2 URI 10-24.061 6.136 7.271 1.00 0.00 C ATOM 7028 02 URI 10-24.935 6.864 7.737 1.00 0.00 0 ATOM 7029 N3 URI 10-24.326 5.260 6.234 1.00 0.00 N ATOM 7030 C4 URI 10-23.419 4.403 5.636 1.00 0.00 C ATOM 7031 04 URI 10-23.768 3.665 4.717 1.00 0.00 O ATOM 7032 C5 URI 10-22. 087 4.477 6.189 1.00 0.00 C ATOM 7033 C2'URI 10-22.992 6.543 10.180 1.00 0.00 C ATOM 7034 02'URI 10-24. 358 6.928 10.373 1.00 0.00 O ATOM 7035 C3'URI 10-22.073 7.225 11.174 1.00 0.00 C ATOM 7036 03'URI 10-22.470 8.597 11.296 1.00 0.00 O ATOM 7037 1H5'URI 10-19. 841 5.916 11.958 1.00 0.00 H ATOM 7038 2H5'URI 10-20.443 5.052 10.529 1.00 0.00 H ATOM 7039 H4'URI 10-20.157 8.077 10.711 1.00 0.00 H ATOM 7040 H1'URI 10-22.859 8.049 8.654 1.00 0.00 H ATOM 7041 H6 URI 10-20.784 5.364 7.595 1.00 0.00 H ATOM 7042 H3 URI 10-25.272 5.244 5.880 1.00 0.00 H ATOM 7043 H5 URI 10-21.301 3.839 5.785 1.00 0.00 H ATOM 7044 H2'URI 10-22.872 5.458 10.239 1.00 0.00 H ATOM 7045 H02'URI 10-24.391 7.887 10.345 1.00 0.00 H ATOM 7046 H3'URI 10-22.051 6.712 12.136 1.00 0.00 H ATOM 7047 P GUA 11-21.897 9.522 12.486 1.00 0.00 P ATOM 7048 01P GUA 11-22.023 8.774 13.757 1.00 0.00 O ATOM 7049 02P GUA 11-22.507 10.865 12.359 1.00 0.00 0 ATOM 7050 05'GUA 11-20.329 9.649 12.123 1. 00 0.00 0 ATOM 7051 C5'GUA 11-19.326 9.113 12.996 1.00 0.00 C ATOM 7052 C4'GUA 11-17.969 9.782 12.780 1. 00 0.00 C ATOM 7053 04'GUA 11-17.515 9.637 11.423 1.00 0.00 0 ATOM 7054 C1'GUA 11-17.124 10.924 10.912 1.00 0.00 C ATOM 7055 N9 GUA 11-18.167 11.485 10.040 1.00 0.00 N ATOM 7056 C4 GUA 11-18. 137 12.702 9.404 1.00 0.00 C ATOM 7057 N3 GUA 11-17.131 13.602 9.469 1.00 0. 00 N ATOM 7058 C2 GUA 11-17.385 14.693 8.744 1.00 0.00 C ATOM 7059 N2 GUA 11-16.493 15.681 8.695 1.00 0.00 N ATOM 7060 N1 GUA 11-18.543 14.875 8.015 1.00 0.00 N ATOM 7061 C6 GUA 11-19. 589 13.965 7.934 1.00 0. 00 C ATOM 7062 06 GUA 11-20.580 14.221 7.255 1.00 0. 00 0 ATOM 7063 C5 GUA 11-19.327 12. 801 8.702 1.00 0.00 C

ATOM 7064 N7 GUA 11-20.106 11.656 8.891 1.00 0.00 N ATOM 7065 C8 GUA 11-19.356 10.958 9.675 1.00 0.00 C ATOM 7066 C2'GUA 11-16.921 11.791 12.141 1.00 0.00 C ATOM 7067 02'GUA 11-15.639 11.566 12.742 1.00 0.00 0 ATOM 7068 C3'GUA 11-18.049 11.284 13.014 1.00 0.00 C ATOM 7069 03'GUA 11-17.735 11.557 14.382 1.00 0.00 0 ATOM 7070 1H5'GUA 11-19.228 8.043 12.812 1.00 0.00 H ATOM 7071 2H5'GUA 11-19.636 9.268 14.030 1.00 0.00 H ATOM 7072 H4'GUA 11-17.234 9.345 13.454 1.00 0.00 H ATOM 7073 H1'GUA 11-16.191 10.837 10.355 1.00 0.00 H ATOM 7074 1H2 GUA 11-16.684 16.508 8.147 1.00 0.00 H ATOM 7075 2H2 GUA 11-15. 626 15.604 9.207 1.00 0.00 H ATOM 7076 H1 GUA 11-18.660 15.731 7.494 1.00 0.00 H ATOM 7077 H8 GUA 11-19.667 9.980 10.035 1.00 0.00 H ATOM 7078 H2'GUA 11-17.067 12.846 11.895 1.00 0.00 H ATOM 7079 H02'GUA 11-15.551 10.620 12.878 1.00 0.00 H ATOM 7080 H3'GUA 11-19.014 11.696 12.713 1.00 0.00 H ATOM 7081 P CYT 12-18.431 12.794 15.142 1.00 0.00 P ATOM 7082 O1P CYT 12-19.895 12. 693 14.947 1.00 0.00 0 ATOM 7083 02P CYT 12-17. 872 12.868 16.511 1.00 0.00 O ATOM 7084 05'CYT 12-17.897 14.063 14.307 1.00 0.00 O ATOM 7085 C5'CYT 12-16.536 14.488 14.424 1.00 0.00 C ATOM 7086 C4'CYT 12-16.260 15.739 13.595 1.00 0.00 C ATOM 7087 04'CYT 12-16.493 15.518 12.200 1.00 0.00 0 ATOM 7088 C1'CYT 12-17.116 16.686 11.628 1.00 0.00 C ATOM 7089 N1 CYT 12-18.489 16.389 11.158 1.00 0.00 N ATOM 7090 C6 CYT 12-19.099 15.204 11.464 1.00 0.00 C ATOM 7091 C2 CYT 12-19.127 17.351 10.384 1.00 0.00 C ATOM 7092 02 CYT 12-18.566 18.416 10.130 1.00 0.00 0 ATOM 7093 N3 CYT 12-20.381 17.086 9.929 1.00 0.00 N ATOM 7094 C4 CYT 12-20.989 15.929 10.220 1.00 0.00 C ATOM 7095 N4 CYT 12-22.214 15.699 9.752 1.00 0.00 N ATOM 7096 C5 CYT 12-20.340 14.936 11.019 1.00 0.00 C ATOM 7097 C2'CYT 12-17.123 17.740 12.732 1.00 0.00 C ATOM 7098 02'CYT 12-15. 927 18.527 12.710 1.00 0.00 0 ATOM 7099 C3'CYT 12-17.199 16.871 13.969 1.00 0.00 C ATOM 7100 03'CYT 12-16.637 17.584 15.075 1.00 0.00 0 ATOM 7101 1H5'CYT 12-15.882 13.685 14.084 1.00 0.00 H ATOM 7102 2H5'CYT 12-16.320 14.702 15.472 1.00 0.00 H ATOM 7103 H4'CYT 12-15.228 16.056 13.742 1.00 0.00 H ATOM 7104 H1'CYT 12-16.514 17.043 10.792 1.00 0.00 H ATOM 7105 H6 CYT 12-18.574 14.466 12.071 1. 00 0.00 H ATOM 7106 1H4 CYT 12-22. 680. 14.828 9.962 1.00 0.00 H ATOM 7107 2H4 CYT 12-22.676 16.395 9.185 1.00 0.00 H ATOM 7108 H5 CYT 12-20. 834 13.996 11.261 1.00 0.00 H ATOM 7109 H2'CYT 12-18.011 18.369 12.649 1.00 0.00 H ATOM 7110 H02'CYT 12-15.187 17.917 12.674 1.00 0.00 H ATOM 7111 H3'CYT 12-18.215 16.521 14.161 1.00 0.00 H ATOM 7112 P URI 13-17.589 18.365 16.112 1.00 0.00 P ATOM 7113 01P URI 13-18. 739 17.491 16.437 1.00 0.00 0 ATOM 7114 02P URI 13-16.744 18.907 17.199 1.00 0.00 0 ATOM 7115 05'URI 13-18.128 19.596 15.227 1.00 0.00 0 ATOM 7116 C5'URI 13-17.266 20.690 14.903 1.00 0.00 C ATOM 7117 C4'URI 13-17.937 21.666 13.942 1.00 0.00 C ATOM 7118 04'URI 13-18. 266 21. 043 12.695 1.00 0.00 O ATOM 7119 C1'URI 13-19.539 21.539 12.235 1.00 0.00 C ATOM 7120 N1 URI 13-20.550 20.459 12.167 1.00 0.00 N ATOM 7121 C6 URI 13-20.397 19.295 12.876 1.00 0.00 C ATOM 7122 C2 URI 13-21.646 20.663 11.347 1.00 0.00 C ATOM 7123 02 URI 13-21.806 21.702 10.710 1.00 0.00 0

ATOM 7124 N3 URI 13-22.560 19.629 11.285 1.00 0.00 N ATOM 7125 C4 URI 13-22.479 18.425 11.961 1.00 0.00 C ATOM 7126 04 URI 13-23.347 17.567 11.816 1.00 0.00 O ATOM 7127 C5 URI 13-21.308 18.296 12.797 1.00 0.00 C ATOM 7128 C2'URI 13-19.955 22.623 13.227 1.00 0.00 C ATOM 7129 02'URI 13-19.486 23.914 12.820 1.00 0. 00 0 ATOM 7130 C3'URI 13-19.265 22.151 14.489 1.00 0.00 C ATOM 7131 03'URI 13-19.031 23. 278 15.339 1.00 0.00 O ATOM 7132 1H5'URI 13-16.356 20.305 14.442 1.00 0.00 H ATOM 7133 2H5'URI 13-17.004 21.219 15.820 1.00 0.00 H ATOM 7134 H4'URI 13-17.281 22.516 13.760 1.00 0.00 H ATOM 7135 H1'URI 13-19.416 21.984 11.247 1.00 0.00 H ATOM 7136 H6 URI 13-19.528 19. 172 13. 522 1.00 0.00 H ATOM 7137 H3 URI 13-23.366 19.768 10.694 1.00 0.00 H ATOM 7138 H5 URI 13-21.156 17.383 13.372 1.00 0.00 H ATOM 7139 H2'URI 13-21.039 22.621 13.360 1.00 0.00 H ATOM 7140 H02'URI 13-19.410 24.452 13.611 1.00 0.00 H ATOM 7141 H3'URI 13-19.822 21.355 14.986 1.00 0.00 H ATOM 7142 P CYT 14-20.096 23.669 16.481 1.00 0.00 P ATOM 7143 O1P CYT 14-19.530 24.778 17.282 1.00 0.00 O ATOM 7144 02P CYT 14-20. 535 22.425 17.151 1.00 0.00 O ATOM 7145 05'CYT 14-21.332 24.242 15.624 1.00 0.00 ci ATOM 7146 C5'CYT 14-21.282 25. 558 15.064 1.00 0.00 C ATOM 7147 C4'CYT 14-22.522 25.858 14.227 1.00 0.00 C ATOM 7148 04'CYT 14-22.654 24.948 13.130 1.00 0.00 O ATOM 7149 C1'CYT 14-24.049 24.646 12.924 1.00 0.00 C ATOM 7150 N1 CYT 14-24.325 23.204 13.104 1.00 0.00 N ATOM 7151 C6 CYT 14-23.562 22.440 13.939 1.00 0.00 C ATOM 7152 C2 CYT 14-25.389 22.661 12.396 1.00 0.00 C ATOM 7153 02 CYT 14-26.069 23.371 11.657 1.00 0.00 O ATOM 7154 N3 CYT 14-25.659 21.337 12.552 1.00 0.00 N ATOM 7155 C4 CYT 14-24.919 20.576 13.366 1.00 0.00 C ATOM 7156 N4 CYT 14-25. 209 19. 282 13.492 1.00 0.00 N ATOM 7157 C5 CYT 14-23.823 21.130 14.099 1.00 0.00 C ATOM 7158 C2'CYT 14-24.823 25. 477 13.945 1.00 0.00 C ATOM 7159 02'CYT 14-25.248 26.728 13.390 1.00 0.00 0 ATOM 7160 C3'CYT 14-23.789 25.669 15.036 1.00 0.00 C ATOM 7161 03'CYT 14-24.075 26.884 15.735 1.00 0.00 0 ATOM 7162 1H5'CYT 14-20.397 25.646 14.434 1.00 0.00 H ATOM 7163 2H5'CYT 14-21.216 26.286 15.873 1.00 0.00 H ATOM 7164 H4'CYT 14-22.475 26.878 13.848 1.00 0.00 H ATOM 7165 H1'CYT 14-24.339 24.949 11.918 1.00 0.00 H ATOM 7166 H6 CYT 14-22.735 22.896 14.484 1.00 0.00 H ATOM 7167 1H4 CYT 14-24.656 18.696 14.102 1.00 0.00 H ATOM 7168 2H4 CYT 14-25.986 18.887 12.980 1.00 0.00 H ATOM 7169 H5 CYT 14-23.223 20.516 14.767 1.00 0.00 H ATOM 7170 H2'CYT 14-25.674 24.905 14.325 1.00 0.00 H ATOM 7171 H02'CYT 14-25.962 26.540 12.776 1.00 0.00 H ATOM 7172 H3'CYT 14-23.729 24.804 15.699 1.00 0. 00 H ATOM 7173 P URI 15-25.039 26.874 17.024 1.00 0.00 P ATOM 7174 01P URI 15-24.522 25.870 17.982 1.00 0.00 0 ATOM 7175 02P URI 15-25.243 28.274 17.461 1.00 0.00 0 ATOM 7176 05'URI 15-26.427 26.325 16.420 1.00 0.00 0' ATOM 7177 C5'URI 15-27.219 27.142 15.554 1.00 0.00 C ATOM 7178 C4'URI 15-28.348 26.345 14.905 1.00 0.00 C ATOM 7179 04'URI 15-27.845 25.275 14.089 1.00 0.00 0 ATOM 7180 C1'URI 15-28.626 24.086 14.324 1.00 0.00 C ATOM 7181 N1 URI 15-27.840 23.062 15.049 1.00 0.00 N ATOM 7182 C6 URI 15-26.921 23.421 15.998 1.00 0.00 C ATOM 7183 C2 URI 15-28.073 21.733 14.738 1.00 0.00 C

ATOM 7184 02 URI 15-28. 899 21.391 13.895 1.00 0. 00 ATOM 7185 N3 URI 15-27.326 20.806 15.439 1.00 0.00 N ATOM 7186 C4 URI 15-26.382 21.084 16.411 1. 00 0.00 C ATOM 7187 04 URI 15-25.773 20.175 16.971 1.00 0.00 0 ATOM 7188 C5 URI 15-26. 204 22.494 16. 672 1.00 0.00 C ATOM 7189 C2'URI 15-29.826 24.536 15.148 1.00 0.00 C ATOM 7190 02'URI 15-30.896 24.998 14.314 1.00 0.00 0 ATOM 7191 C3'URI 15-29.213 25.665 15.951 1.00 0. 00 C ATOM 7192 03'URI 15-30.247 26.569 16.350 1.00 0.00 0 ATOM 7193 1H5'URI 15-26.582 27.557 14.772 1.00 0.00 H ATOM 7194 2H5'URI 15-27.650 27.959 16.133 1.00 0.00 H ATOM 7195 H4'URI 15-28.961 27.006 14.294 1.00 0.00 H ATOM 7196 Hl'URI 15-28.968 23.680 13.371 1.00 0.00 H ATOM 7197 H6 URI 15-26.763 24.477 16.214 1.00 0.00 H ATOM 7198 H3 URI 15-27.485 19.832 15.222 1.00 0.00 H ATOM 7199 H5 URI 15-25.488 22.817 17.425 1.00 0.00 H ATOM 7200 H2'URI 15-30.157 23.731 15.807 1.00 0.00 H ATOM 7201 H02'URI 15-31.226 24.238 13.826 1.00 0.00 H ATOM 7202 H3'URI 15-28.626 25.294 16.794 1.00 0.00 H ATOM 7203 P URI 16-31.140 26.265 17.654 1.00 0. 00 P ATOM 7204 01P URI 16-31.973 27.457 17.933 1.00 0.00 0 ATOM 7205 02P URI 16-30.254 25.719 18.707 1. 00 0. 00 0 ATOM 7206 05'URI 16-32.105 25.081 17.143 1.00 0.00 0 ATOM 7207 C5'URI 16-33.203 24.636 17.945 1. 00 0.00 C ATOM 7208 C4'URI 16-34.532 24.822 17.221 1.00 0.00 C ATOM 7209 04'URI 16-34.674 26.165 16.734 1.00 0.00 0 ATOM 7210 C1'URI 16-34.914 26.143 15.323 1.00 0.00 C ATOM 7211 N1 URI 16-34.288 27.305 14.652 1.00 0.00 N ATOM 7212 C6 URI 16-32.937 27.522 14.731 1.00 0.00 C ATOM 7213 C2 URI 16-35.116 28.160 13.945 1.00 0.00 C ATOM 7214 02 URI 16-36.330 27.980 13.863 1.00 0.00 0 ATOM 7215 N3 URI 16-34.498 29.234 13.332 1.00 0.00 N ATOM 7216 C4 URI 16-33.146 29. 525 13.362 1.00 0.00 C ATOM 7217 04 URI 16-32.705 30.512 12.777 1.00 0. 00 0 ATOM 7218 C5 URI 16-32.357 28.582 14.121 1.00 0.00 C ATOM 7219 C2'URI 16-34.312 24.836 14.836 1.00 0.00 C ATOM 7220 02'URI 16-34.926 24.393 13.621 1.00 0. 00 0 ATOM 7221 C3'URI 16-34.626 23.909 15.997 1.00 0.00 C ATOM 7222 03'URI 16-35.980 23. 461 15.873 1.00 0.00 0 ATOM 7223 1H5'URI 16-33.220 25.199 18.875 1.00 0.00 H ATOM 7224 2H5'URI 16-33.071 23.580 18.176 1.00 0.00 H ATOM 7225 H4'URI 16-35.351 24.600 17.904 1.00 0. 00 H ATOM 7226 H1'URI 16-35.988 26.143 15.134 1.00 0.00 H ATOM 7227 H6 URI 16-32.317 26.827 15.295 1.00 0.00 H ATOM 7228 H3 URI 16-35.090 29.865 12.812 1.00 0. 00 H ATOM 7229 H5 URI 16-31.279 28.727 14.204 1.00 0. 00 H ATOM 7230 H2'URI 16-33.230 24.936 14.720 1.00 0.00 H ATOM 7231 H02'URI 16-34.605 23.505 13.445 1.00 0.00 H ATOM 7232 H3'URI 16-33.924 23. 076 16.054 1.00 0.00 H ATOM 7233 P CYT 17-36.581 22.389 16.914 1.00 0.00 P ATOM 7234 01P CYT 17-36.618 23.012 18.256 1.00 0.00 0 ATOM 7235 02P CYT 17-37.817 21. 820 16.331 1.00 0.00 O ATOM 7236 05'CYT 17-35.450 21.241 16.922 1.00 0.00 0 ATOM 7237 C5'CYT 17-35.318 20.349 15.813 1.00 0. 00 C ATOM 7238 C4'CYT 17-34.248 19.292 16.055 1.00 0.00 C ATOM 7239 04'CYT 17-32.942 19.878 16.156 1.00 0. 00 0 ATOM 7240 Cl'CYT 17-32.311 19.406 17.346 1.00 0.00 C ATOM 7241 N1 CYT 17-31.355 20.397 17.877 1.00 0. 00 N ATOM 7242 C6 CYT 17-31.498 21.720 17. 592 1.00 0. 00 C ATOM 7243 C2 CYT 17-30.306 19.933 18. 661 1. 00 0. 00 C

ATOM 7244 02 CYT 17-30.199 18.733 18. 905 1.00 0.00 0 ATOM 7245 N3 CYT 17-29.413 20.841 19.143 1.00 0.00 N ATOM 7246 C4 CYT 17-29.543 22.145 18.869 1.00 0.00 C ATOM 7247 N4 CYT 17-28.650 23.008 19.354 1.00 0.00 N ATOM 7248 C5 CYT 17-30.623 22.622 18.063 1.00 0.00 C ATOM 7249 C2'CYT 17-33.454 19.157 18.309 1.00 0.00 C ATOM 7250 02'CYT 17-33.085 18.244 19.350 1.00 0.00 O ATOM 7251 C3'CYT 17-34.494 18.559 17.373 1.00 0.00 C ATOM 7252 03'CYT 17-34.189 17.173 17.180 1.00 0.00 O ATOM 7253 1H5'CYT 17-35.056 20.920 14.929 1.00 0.00 H ATOM 7254 2H5'CYT 17-36.271 19.854 15.646 1.00 0.00 H ATOM 7255 H4'CYT 17-34.257 18.576 15.236 1.00 0.00 H ATOM 7256 H1'CYT 17-31.796 18.471 17.141 1.00 0.00 H ATOM 7257 H6 CYT 17-32.331 22.049 16.972 1.00 0.00 H ATOM 7258 1H4 CYT 17-28.739 23.994 19.151 1.00 0.00 H ATOM 7259 2H4 CYT 17-27. 885 22. 677 19.924 1.00 0.00 H ATOM 7260 H5 CYT 17-30.737 23.679 17.840 1.00 0.00 H ATOM 7261 H2'CYT 17-33.817 20.104 18.719 1.00 0.00 H ATOM 7262 H02'CYT 17-32.363 18.646 19.839 1.00 0.00 H ATOM 7263 H3'CYT 17-35.510 18.714 17.735 1.00 0.00 H ATOM 7264 P GUA 18-35.366 16.078 17.064 1.00 0.00 P ATOM 7265 01P GUA 18-34.744 14.745 16.900 1.00 0.00 0 ATOM 7266 02P GUA 18-36.327 16. 313 18.165 1.00 0.00 0 ATOM 7267 05'GUA 18-36.083 16.474 15.677 1.00 0.00 O ATOM 7268 C5'GUA 18-35.410 16.295 14.427 1.00 0.00 C ATOM 7269 C4'GUA 18-36.146 17.000 13.291 1.00 0.00 C ATOM 7270 04'GUA 18-36.271 18.399 13.537 1.00 0.00 O ATOM 7271 C1'GUA 18-36.231 19.111 12.288 1.00 0.00 C ATOM 7272 N9 GUA 18-35.200 20.170 12.313 1.00 0.00 N ATOM 7273 C4 GUA 18-33.890 20.043 12.725 1.00 0.00 C ATOM 7274 N3 GUA 18-33.302 18.908 13.166 1. 00 0.00 N ATOM 7275 C2 GUA 18-32.021 19.099 13.497 1.00 0.00 C ATOM 7276 N2 GUA 18-31.293 18.080 13.955 1.00 0.00 N ATOM 7277 N1 GUA 18-31.377 20.316 13.399 1.00 0.00 N ATOM 7278 C6 GUA 18-31.958 21.494 12.949 1.00 0.00 C ATOM 7279 06 GUA 18-31.298 22.530 12.903 1.00 0.00 0 ATOM 7280 C5 GUA 18-33.320 21.301 12.595 1.00 0.00 C ATOM 7281 N7 GUA 18-34. 254 22.217 12.104 1.00 0.00 N ATOM 7282 C8 GUA 18-35.303 21.479 11.972 1. 00 0.00 C ATOM 7283 C2'GUA 18-35.941 18.075 11.197 1.00 0.00 C ATOM 7284 02'GUA 18-37.137 17.706 10.500 1.00 0.00 O ATOM 7285 C3'GUA 18-35. 375 16.907 11.989 1. 00 0. 00 C ATOM 7286 03'GUA 18-35.741 15.687 11.332 1.00 0.00 0 ATOM 7287 1H5'GUA 18-35.348 15.230 14.204 1.00 0.00 H ATOM 7288 2H5'GUA 18-34. 401 16.701 14.504 1.00 0.00 H ATOM 7289 H4'GUA 18-37.136 16.565 13.165 1.00 0.00 H ATOM 7290 H1'GUA 18-37. 206 19.562 12.101 1.00 0.00 H ATOM 7291 1H2 GUA 18-30. 325 18.223 14.206 1.00 0.00 H ATOM 7292 2H2 GUA 18-31.709 17.165 14.051 1.00 0.00 H ATOM 7293 H1 GUA 18-30.406 20.379 13.670 1.00 0.00 H ATOM 7294 H8 GUA 18-36. 240 21.892 11.599 1.00 0.00 H ATOM 7295 H2'GUA 18-35.189 18.461 10.503 1.00 0. 00 H ATOM 7296 H02'GUA 18-36.911 16.981 9.912 1.00 0.00 H ATOM 7297 H3'GUA 18-34. 298 16.997 12.139 1.00 0.00 H ATOM 7298 P GUA 19-34. 871 15.120 10.101 1.00 0.00 P ATOM 7299 O1P GUA 19-35. 515 13.882 9.610 1.00 0.00 0 ATOM 7300 02P GUA 19-33. 448 15.099 10.512 1.00 0.00 0 ATOM 7301 05'GUA 19-35. 058 16.264 8.981 1.00 0.00 O ATOM 7302 C5'GUA 19-33.953 16.687 8.177 1.00 0.00 C ATOM 7303 C4'GUA 19-33.932 18.204 8.004 1.00 0.00 C

ATOM 7304 04'GUA 19-33.877 18.875 9.274 1.00 0.00 O ATOM 7305 Cl'GUA 19-32.789 19.814 9.276 1.00 0.00 C ATOM 7306 N9 GUA 19-31.628 19.281 10.015 1.00 0.00 N ATOM 7307 C4 GUA 19-30.500 19.978 10.391 1.00 0.00 C ATOM 7308 N3 GUA 19-30. 258 21.287 10.149 1.00 0.00 N ATOM 7309 C2 GUA 19-29.077 21.680 10.637 1.00 0.00 C ATOM 7310 N2 GUA 19-28. 679 22.942 10.482 1.00 0.00 N ATOM 7311 N1 GUA 19-28.209 20.843 11.309 1.00 0.00 N ATOM 7312 C6 GUA 19-28.436 19.498 11.570 1.00 0.00 C ATOM 7313 06 GUA 19-27.598 18.839 12.181 1.00 0.00 O ATOM 7314 C5 GUA 19-29.688 19.071 11.055 1.00 0.00 C ATOM 7315 N7 GUA 19-30.291 17.811 11. 101 1.00 0.00 N ATOM 7316 C8 GUA 19-31.400 18.027 10.480 1.00 0.00 C ATOM 7317 C2'GUA 19-32.452 20.040 7.811 1.00 0.00 C ATOM 7318 02'GUA 19-33.320 21.011 7.215 1.00 0.00 0 ATOM 7319 C3'GUA 19-32.687 18.652 7.248 1.00 0.00 C ATOM 7320 03'GUA 19-33.012 18.769 5.858 1.00 0.00 0 ATOM 7321 1H5'GUA 19-34.026 16.218 7.196 1. 00 0.00 H ATOM 7322 2H5'GUA 19-33.024 16.371 8.653 1.00 0.00 H ATOM 7323 H4'GUA 19-34.823 18.524 7.465 1.00 0.00 H ATOM 7324 Hl'GUA 19-33.114 20.751 9.727 1.00 0.00 H ATOM 7325 1H2 GUA 19-29.270 23. 602 9.997 1.00 0.00 H ATOM 7326 2H2 GUA 19-27.786 23.239 10.850 1.00 0.00 H ATOM 7327 H1 GUA 19-27. 335 21.217 11.647 1.00 0.00 H ATOM 7328 H8 GUA 19-32.128 17.230 10.332 1.00 0.00 H ATOM 7329 H2'GUA 19-31.403 20.326 7.703 1.00 0.00 H ATOM 7330 H02'GUA 19-33.111 21.861 7.609 1.00 0.00 H ATOM 7331 H3'GUA 19-31.837 17.991 7.427 1.00 0.00 H ATOM 7332 P ADE 20-31.876 18.582 4.731 1.00 0. 00 P ATOM 7333 01P ADE 20-31.146 17.327 5.014 1.00 0. 00 0 ATOM 7334 02P ADE 20-32.502 18.788 3.405 1.00 0.00 0 ATOM 7335 05'ADE 20-30.885 19.819 5.021 1.00 0.00 0 ATOM 7336 C5'ADE 20-31.273 21.156 4.690 1.00 0.00 C ATOM 7337 C4'ADE 20-30.276 22.182 5.222 1.00 0.00 C ATOM 7338 04'ADE 20-30.140 22. 101 6.646 1.00 0.00 0 ATOM 7339 C1'ADE 20-28.756 22.291 7.007 1.00 0.00 C ATOM 7340 N9 ADE 20-28.185 21.071 7.612 1.00 0.00 N ATOM 7341 C4 ADE 20-27.012 20.982 8.330 1.00 0.00 C ATOM 7342 N3 ADE 20-26.160 21.992 8.596 1.00 0.00 N ATOM 7343 C2 ADE 20-25.123 21.573 9.313 1.00 0.00 C ATOM 7344 N1 ADE 20-24.892 20.333 9.748 1.00 0.00 N ATOM 7345 C6 ADE 20-25.757 19.342 9.471 1.00 0.00 C ATOM 7346 N6 ADE 20-25.515 18.115 9.930 1.00 0.00 N ATOM 7347 C5 ADE 20-26.890 19.668 8.717 1.00 0.00 C ATOM 7348 N7 ADE 20-27.970 18.910 8.253 1.00 0.00 N ATOM 7349 C8 ADE 20-28.663 19. 802 7.627 1.00 0.00 C ATOM 7350 C2'ADE 20-28.031 22.651 5. 716 1.00 0.00 C ATOM 7351 02'ADE 20-28.024 24.066 5.495 1.00 0.00 O ATOM 7352 C3'ADE 20-28.877 21.929 4.689 1.00 0.00 C ATOM 7353 03'ADE 20-28.733 22.588 3.428 1.00 0.00 0 ATOM 7354 lH5'ADE 20-32.255 21.358 5.119 1.00 0.00 H ATOM 7355 2H5'ADE 20-31.334 21.249 3.605 1.00 0.00 H ATOM 7356 H4'ADE 20-30.597 23.185 4.947 1.00 0.00 H ATOM 7357 H1'ADE 20-28.676 23.119 7.712 1.00 0.00 H ATOM 7358 H2 ADE 20-24.378 22.325 9.574 1.00 0.00 H ATOM 7359 1H6 ADE 20-26. 165 17.366 9.735 1.00 0.00 H ATOM 7360 2H6 ADE 20-24. 685'17. 934 10.476 1.00 0.00 H ATOM 7361 H8 ADE 20-29.592 19.542 7.122 1.00 0.00 H ATOM 7362 H2'ADE 20-27. 015 22.249 5.726 1.00 0.00 H ATOM 7363 H02'ADE 20-27.824 24.209 4.567 1.00 0.00 H

ATOM 7364 H3'ADE 20-28.641 20. 864 4.640 1. 00 0.00 H ATOM 7365 P GUA 21-27.559 22.157 2.413 1.00 0. 00 P ATOM 7366 OIT GUA 21-27.688 22.971 1.183 1.00 0.00 0 ATOM 7367 02P GUA 21-27.545 20.680 2.320 1.00 0.00 O ATOM 7368 05'GUA 21-26.228 22.625 3.193 1.00 0.00 O ATOM 7369 C5'GUA 21-25.753 23.970 3.080 1.00 0.00 C ATOM 7370 C4'GUA 21-24.379 24.145 3.723 1.00 0.00 C ATOM 7371 04'GUA 21-24.403 23.870 5.128 1.00 0.00 0 ATOM 7372 C1'GUA 21-23.179 23.204 5.503 1.00 0.00 C ATOM 7373 N9 GUA 21-23.444 21.841 6.004 1.00 0.00 N ATOM 7374 C4 GUA 21-22.631 21.098 6.832 1.00 0.00 C ATOM 7375 N3 GUA 21-21.428 21.483 7.318 1.00 0.00 N ATOM 7376 C2 GUA 21-20.874 20.547 8.094 1.00 0.00 C ATOM 7377 N2 GUA 21-19.679 20.759 8.647 1.00 0.00 N ATOM 7378 N1 GUA 21-21.466 19.331 8.368 1.00 0.00 N ATOM 7379 C6 GUA 21-22.699 18.914 7.883 1.00 0. 00 C ATOM 7380 06 GUA 21-23.143 17.812 8.194 1.00 0.00 0 ATOM 7381 C5 GUA 21-23.294 19.901 7.054 1.00 0.00 C ATOM 7382 N7 GUA 21-24.514 19.880 6.374 1.00 0.00 N ATOM 7383 C8 GUA 21-24.514 21.034 5.798 1.00 0.00 C ATOM 7384 C2'GUA 21-22. 316 23.168 4.245 1.00 0.00 C ATOM 7385 02'GUA 21-21.472 24.323 4.152 1.00 0.00 O ATOM 7386 C3'GUA 21-23.374 23.158 3.162 1.00 0.00 C ATOM 7387 03'GUA 21-22.818 23.699 1.960 1. 00 0.00 0 ATOM 7388 1H5'GUA 21-26.461 24.640 3.568 1.00 0.00 H ATOM 7389 2H5'GUA 21-25.686 24.234 2.025 1.00 0.00 H ATOM 7390 H4'GUA 21-24.024 25.162 3.561 1.00 0.00 H ATOM 7391 Hl'GUA 21-22.672 23.783 6.276 1.00 0.00 H ATOM 7392 1H2 GUA 21-19.192 21.628 8.478 1.00 0.00 H ATOM 7393 2H2 GUA 21-19.258 20.050 9. 230 1.00 0.00 H ATOM 7394 H1 GUA 21-20.982 18.676 8.965 1.00 0.00 H ATOM 7395 H8 GUA 21-25.339 21.345 5.158 1.00 0.00 H ATOM 7396 H2'GUA 21-21.729 22.248 4.215 1.00 0.00 H ATOM 7397 H02'GUA 21-22.043 25.095 4.171 1. 00 0. 00 H ATOM 7398 H3'GUA 21-23.805 22.166 3.020 1.00 0.00 H ATOM 7399 P ADE 22-22.128 22.730 0.873 1.00 0.00 P ATOM 7400 01P ADE 22-21.936 23.499-0. 377 1.00 0.00 0 ATOM 7401 02P ADE 22-22.878 21.454 0.846 1.00 0.00 0 ATOM 7402 05'ADE 22-20.681 22.450 1.522 1.00 0.00 0 ATOM 7403 C5'ADE 22-19.689 23.480 1.550 1.00 0.00 C ATOM 7404 C4'ADE 22-18.527 23. 123 2.472 1.00 0.00 C ATOM 7405 04'ADE 22-18.971 22.859 3.806 1.00 0.00 0 ATOM 7406 C1'ADE 22-18.202 21.774 4.360 1.00 0.00 C ATOM 7407 N9 ADE 22-19.052 20.603 4. 650 1.00 0.00 N ATOM 7408 C4 ADE 22-18.808 19.630 5.589 1.00 0.00 C ATOM 7409 N3 ADE 22-17.741 19.564 6.410 1.00 0.00 N ATOM 7410 C2 ADE 22-17.805 18.498 7.200 1.00 0.00 C ATOM 7411 N1 ADE 22-18.768 17.575 7.231 1. 00 0.00 N ATOM 7412 C6 ADE 22-19.823 17.664 6.402 1.00 0.00 C ATOM 7413 N6 ADE 22-20.777 16.737 6.454 1.00 0.00 N ATOM 7414 C5 ADE 22-19.861 18.748 5.522 1.00 0.00 C ATOM 7415 N7 ADE 22-20.780 19.145 4.547 1.00 0.00 N ATOM 7416 C8 ADE 22-20.231 20.222 4.096 1.00 0.00 C ATOM 7417 C2'ADE 22-17.139 21.435 3.319 1. 00 0.00 C ATOM 7418 02'ADE 22-15.941 22.191 3.531 1. O0 0. 00 O ATOM 7419 C3'ADE 22-17.840 21.840 2.038 1.00 0.00 C ATOM 7420 03'ADE 22-16.855 22.155 1.049 1.00 0.00 O ATOM 7421 1H5'ADE 22-20.147 24.406 1.901 1.00 0.00 H ATOM 7422 2H5'ADE 22-19.308 23.633 0.541 1.00 0.00 H ATOM 7423 H4'ADE 22-17.806 23.938 2.487 1.00 0.00 H

ATOM 7424 H1'ADE 22-17.716 22.106 5.278 1.00 0. 00 H ATOM 7425 H2 ADE 22-16.978 18.362 7.897 1.00 0.00 H ATOM 7426 1H6 ADE 22-21.575 16.799 5.839 1. 00 0.00 H ATOM 7427 2H6 ADE 22-20.703 15.971 7.109 1. 00 0.00 H ATOM 7428 H8 ADE 22-20.695 20.800 3.297 1.00 0.00 H ATOM 7429 H2'ADE 22-16.934 20. 360 3.320 1.00 0. 00 H ATOM 7430 H02'ADE 22-15.451 21.758 4.234 1.00 0.00 H ATOM 7431 H3'ADE 22-18.550 21.081 1.703 1.00 0.00 H ATOM 7432 P CYT 23-16.127 20.983 0.217 1.00 0.00 P ATOM 7433 O1P CYT 23-17.155 20. 006-0.207 1.00 0.00 O ATOM 7434 02P CYT 23-15.245 21. 611-0.793 1.00 0.00 0 ATOM 7435 05'CYT 23-15.199 20. 283 1. 332 1.00 0.00 0 ATOM 7436 C5'CYT 23-14.093 20.987 1.904 1.00 0.00 C ATOM 7437 C4'CYT 23-13.428 20.183 3.017 1.00 0.00 C ATOM 7438 04'CYT 23-14.339 19.880 4.073 1.00 0.00 0 ATOM 7439 Cl'CYT 23-13.996 18.603 4.646 1.00 0. 00 C ATOM 7440 N1 CYT 23-15.157 17.685 4.644 1.00 0.00 N ATOM 7441 C6 CYT 23-16.019 17.643 3.586 1.00 0. 00 C ATOM 7442 C2 CYT 23-15.335 16.872 5.757 1.00 0.00 C ATOM 7443 02 CYT 23-14.546 16. 928 6.699 1.00 0.00 0 ATOM 7444 N3 CYT 23-16.398 16.022 5.771 1. 00 0.00 N ATOM 7445 C4 CYT 23-17.250 15.968 4.741 1.00 0. 00 C ATOM 7446 N4 CYT 23-18.281 15.125 4.789 1.00 0.00 N ATOM 7447 C5 CYT 23-17.072 16.803 3.593 1.00 0.00 C ATOM 7448 C2'CYT 23-12.844 18.040 3.806 1.00 0.00 C ATOM 7449 02'CYT 23-11.579 18.261 4.441 1.00 0.00 O ATOM 7450 C3'CYT 23-12.967 18.831 2.516 1.00 0.00 C ATOM 7451 03'CYT 23-11.666 18.986 1.945 1.00 0.00 O ATOM 7452 1H5'CYT 23-14.445 21.935 2.311 1.00 0.00 H ATOM 7453 2H5'CYT 23-13. 358 21.187 1.123 1.00 0.00 H ATOM 7454 H4'CYT 23-12.580 20.736 3.418 1.00 0. 00 H ATOM 7455 H1'CYT 23-13.653 18.748 5.670 1.00 0.00 H ATOM 7456 H6 CYT 23-15.856 18. 296 2.729 1. 00 0.00 H ATOM 7457 1H4 CYT 23-18.931 15. 077 4.017 1.00 0.00 H ATOM 7458 2H4 CYT 23-18.412 14.533 5.596 1.00 0.00 H ATOM 7459 H5 CYT 23-17.761 16.759 2.752 1.00 0.00 H ATOM 7460 H2'CYT 23-13.004 16.975 3.613 1.00 0.00 H ATOM 7461 H02'CYT 23-10.897 18.008 3.814 1.00 0.00 H ATOM 7462 H3'CYT 23-13.681 18.381 1.825 1.00 0.00 H ATOM 7463 P GUA 24-11. 381 18.571 0.416 1. 00 0.00 P ATOM 7464 01P GUA 24-11.026 19.794-0. 339 1.00 0. 00 0 ATOM 7465 02P GUA 24-12.489 17.708-0. 051 1. 00 0. 00 0 ATOM 7466 05'GUA 24-10.061 17.663 0.559 1.00 0.00 0 ATOM 7467 C5'GUA 24-8. 838 18.232 1.035 1. 00 0.00 C ATOM 7468 C4'GUA 24-7.996 17.201 1.778 1.00 0.00 C ATOM 7469 04'GUA 24-8.690 16.686 2.927 1.00 0.00 0 ATOM 7470 C1'GUA 24-8.623 15.250 2. 921 1.00 0.00 C ATOM 7471 N9 GUA 24-9.906 14.652 2.514 1. 00 0. 00 N ATOM 7472 C4 GUA 24-10. 191 13.311 2.473 1. 00 0.00 C ATOM 7473 N3 GUA 24-9.340 12.319 2.811 1.00 0. 00 N ATOM 7474 C2 GUA 24-9.892 11.115 2.674 1. 00 0.00 C ATOM 7475 N2 GUA 24-9.187 10.026 2.974 1.00 0.00 N ATOM 7476 N1 GUA 24-11.184 10. 912 2.234 1.00 0. 00 N ATOM 7477 C6 GUA 24-12.077 11.915 1.880 1. 00 0.00 C ATOM 7478 06 GUA 24-13.208 11.625 1.492 1. 00 0.00 0 ATOM 7479 C5 GUA 24-11.497 13.202 2.026 1.00 0.00 C ATOM 7480 N7 GUA 24-12.042 14.468 1.785 1.00 0.00 N ATOM 7481 C8 GUA 24-11.055 15. 240 2.094 1.00 0.00 C ATOM 7482 C2'GUA 24-7.520 14. 901 1.935 1. 00 0. 00 C ATOM 7483 02'GUA 24-6. 225 14.970 2.546 1.00 0.00 0

ATOM 7484 C3'GUA 24-7.710 15. 990 0.901 1.00 0.00 C ATOM 7485 03'GUA 24-6.472 16.202 0.215 1.00 0.00 0 ATOM 7486 1H5'GUA 24-9.065 19.058 1.710 1.00 0.00 H ATOM 7487 2H5'GUA 24-8.269 18.612 0.187 1.00 0.00 H ATOM 7488 H4'GUA 24-7.058 17.653 2.096 1.00 0.00 H ATOM 7489 H1'GUA 24-8.353 14.885 3.911 1.00 0.00 H ATOM 7490 1H2 GUA 24-8.237 10.115 3.305 1.00 0.00 H ATOM 7491 2H2 GUA 24-9.601 9.112 2.871 1.00 0.00 H ATOM 7492 H1 GUA 24-11.527 9.971 2. 159 1.00 0.00 H ATOM 7493 H8 GUA 24-11.145 16.325 2.034 1.00 0.00 H ATOM 7494 H2'GUA 24-7.700 13.918 1.496 1.00 0.00 H ATOM 7495 H02'GUA 24-6.144 15.839 2.945 1.00 0.00 H ATOM 7496 H3'GUA 24-8.536 15.768 0. 223 1.00 0.00 H ATOM 7497 P ADE 25-6.100 15.338-1. 094 1.00 0.00 P ATOM 7498 01P ADE 25-7.328 15.168-1. 903 1.00 0.00 0 ATOM 7499 02P ADE 25-4.889 15.927-1. 707 1.00 0.00 0 ATOM 7500 05'ADE 25-5.705 13.908-0. 470 1.00 0.00 0 ATOM 7501 C5'ADE 25-4.571 13.783 0.393 1.00 0.00 C ATOM 7502 C4'ADE 25-4.484 12.393 1.016 1.00 0.00 C ATOM 7503 04'ADE 25-5.685 12.059 1.725 1.00 0.00 0 ATOM 7504 C1'ADE 25-6.077 10. 712. 1.405 1.00 0.00 C ATOM 7505 N9 ADE 25-7.299 10.695 0.573 1.00 0.00 N ATOM 7506 C4 ADE 25-8.078 9.599 0.275 1.00 0.00 C ATOM 7507 N3 ADE 25-7.863 8.332 0.680 1.00 0.00 N ATOM 7508 C2 ADE 25-8. 802 7.511 0.219 1.00 0.00 C ATOM 7509 N1 ADE 25-9.846 7.830-0. 548 1.00 0.00 N ATOM 7510 C6 ADE 25-10.039 9.101-0. 940 1.00 0.00 C ATOM 7511 N6 ADE 25-11.091 9.400-1. 701 1.00 0.00 N ATOM 7512 C5 ADE 25-9.110 10.055-0. 512 1.00 0.00 C ATOM 7513 N7 ADE 25-9.002 11.433-0. 724 1.00 0.00 N ATOM 7514 C8 ADE 25-7.930 11.715-0. 062 1.00 0.00 C ATOM 7515 C2'ADE 25-4. 894 10.101 0.663 1.00 0.00 C ATOM 7516 02'ADE 25-3.942 9.533 1.571 1.00 0.00 0 ATOM 7517 C3'ADE 25-4.335 11.316-0. 048 1. 00 0.00 C ATOM 7518 03'ADE 25-2.938 11.112-0. 291 1.00 0.00 0 ATOM 7519 1H5'ADE 25-4.648 14.524 1.190 1.00 0.00 H ATOM 7520 2H5'ADE 25-3.664 13.973-0. 181 1.00 0.00 H ATOM 7521 H4'ADE 25-3. 639 12.350 1.700 1.00 0.00 H ATOM 7522 H1'ADE 25-6.256 10.156 2.326 1.00 0.00 H ATOM 7523 H2 ADE 25-8.708 6.462 0.499 1.00 0.00 H ATOM 7524 1H6 ADE 25-11. 246 10.353-1. 996 1.00 0.00 H ATOM 7525 2H6 ADE 25-11.733 8.672-1. 984 1.00 0.00 H ATOM 7526 H8 ADE 25-7.548 12.734-0. 012 1.00 0.00 H ATOM 7527 H2'ADE 25-5.241 9.359-0. 061 1.00 0.00 H ATOM 7528 H02'ADE 25-4.289 8.683 1.853 1.00 0.00 H ATOM 7529 H3'ADE 25-4.892 11.549-0. 957 1.00 0.00 H ATOM 7530 P CYT 26-2.434 10.346-1. 615 1.00 0.00 P ATOM 7531 01P CYT 26-3.258 10.801-2. 758 1.00 0.00 0 ATOM 7532 02P CYT 26-0. 959 10.452-1. 680 1.00 0.00 O ATOM 7533 05'CYT 26-2.817 8.815-1. 298 1.00 0.00 0 ATOM 7534 C5'CYT 26-2.210 8.127-0. 201 1.00 0.00 C ATOM 7535 C4'CYT 26-2.899 6.795 0.078 1.00 0.00 C ATOM 7536 04'CYT 26-4.291 6.967 0.383 1.00 0.00 0 ATOM 7537 C1'CYT 26-5.061 5.969-0. 318 1.00 0.00 C ATOM 7538 N1 CYT 26-5.849 6.567-1. 417 1.00 0.00 N ATOM 7539 C6 CYT 26-5.394 7.664-2. 086 1.00 0.00 C ATOM 7540 C2 CYT 26-7.047 5.953-1. 763 1.00 0.00 C ATOM 7541 02 CYT 26-7.439 4. 965-1. 143 1.00 0.00 0 ATOM 7542 N3 CYT 26-7.763 6.474-2. 795 1.00 0.00 N ATOM 7543 C4 CYT 26-7.325 7.549-3. 462 1.-00 0.00 C

ATOM 7544 N4 CYT 26-8.051 8.034-4. 469 1.00 0.00 N ATOM 7545 C5 CYT 26-6.092 8.182-3. 108 1.00 0.00 C ATOM 7546 C2'CYT 26-4.043 4.978-0. 866 1.00 0.00 C ATOM 7547 02'CYT 26-3.710 3.973 0.100 1.00 0.00 O ATOM 7548 C3'CYT 26-2.875 5.898-1. 147 1.00 0.00 C ATOM 7549 03'CYT 26-1.666 5.133-1. 134 1.00 0.00 0 ATOM 7550 1H5'CYT 26-2.272 8.752 0.690 1.00 0.00 H ATOM 7551 2H5'CYT 26-1.161 7.943-0. 434 1.00 0.00 H ATOM 7552 H4'CYT 26-2.406 6.293 0.910 1.00 0.00 H ATOM 7553 H1'CYT 26-5.727 5.463 0.381 1.00 0.00 H ATOM 7554 H6 CYT 26-4.457 8.133-1. 783 1.00 0.00 H ATOM 7555 1H4 CYT 26-7.730 8.846-4. 978 1.00 0.00 H ATOM 7556 2H4 CYT 26-8.923 7.592-4. 722 1.00 0.00 H ATOM 7557 H5 CYT 26-5.721 9.043-3. 657 1.00 0.00 H ATOM 7558 H2'CYT 26-4.412 4.531-1. 794 1.00 0.00 H ATOM 7559 H02'CYT 26-2. 904 3.546-0. 200 1. 00 0.00 H ATOM 7560 H3'CYT 26-3.012 6.462-2. 073 1.00 0.00 H ATOM 7561 P CYT 27-0.885 4.817-2. 506 1.00 0.00 P ATOM 7562 01P CYT 27 0.310 4.006-2. 184 1.00 0.00 0 ATOM 7563 02P CYT 27-0.738 6.083-3. 258 1.00 0.00 O ATOM 7564 05'CYT 27-1.933 3.883-3. 294 1.00 0.00 O ATOM 7565 C5'CYT 27-2.294 2. 599-2. 776 1.00 0.00 C ATOM 7566 C4'CYT 27-3.471 1.994-3. 536 1.00 0.00 C ATOM 7567 04'CYT 27-4.616 2.850-3. 514 1.00 0.00 0 ATOM 7568 C1'CYT 27-5.333 2.714-4. 759 1.00 0.00 C ATOM 7569 N1 CYT 27-5.457 4.009-5. 466 1.00 0.00 N ATOM 7570 C6 CYT 27-4.758 5.111-5. 060 1. 00 0.00 C ATOM 7571 C2 CYT 27-6.315 4.059-6. 556 1.00 0.00 C ATOM 7572 02 CYT 27-6.924 3.052-6. 912 1.00 0.00 0 ATOM 7573 N3 CYT 27-6.452 5.239-7. 217 1.00 0.00 N ATOM 7574 C4 CYT 27-5.778 6.328-6. 831 1.00 0.00 C ATOM 7575 N4 CYT 27-5.946 7.467-7. 500 1.00 0.00 N ATOM 7576 C5 CYT 27-4.889 6.285-5. 711 1.00 0.00 C ATOM 7577 C2'CYT 27-4.546 1.708-5. 600 1. 00 0.00 C ATOM 7578 02'CYT 27-5.067 0.382-5. 453 1.00 0.00 O ATOM 7579 C3'CYT 27-3.156 1.833-5. 009 1.00 0.00 C ATOM 7580 03'CYT 27-2. 459 0.598-5. 200 1.00 0.00 0 ATOM 7581 1H5'CYT 27-2.566 2.702-1. 726 1. 00 0.00 H ATOM 7582 2H5'CYT 27-1.437 1.930-2. 857 1.00 0.00 H ATOM 7583 H4'CYT 27-3.732 1.029-3. 106 1.00 0.00 H ATOM 7584 H1'CYT 27-6.328 2.315-4. 559 1.00 0.00 H ATOM 7585 H6 CYT 27-4.085 5.039-4. 205 1. 00 0.00 H ATOM 7586 1H4 CYT 27-5.447 8.298-7. 218 1. 00 0. 00 H ATOM 7587 2H4 CYT 27-6. 573 7.498-8. 292 1. 00 0.00 H ATOM 7588 H5 CYT 27-4.333 7.170-5. 399 1.00 0.00 H ATOM 7589 H2'CYT 27-4.542 2.015-6. 649 1.00 0.00 H ATOM 7590 H02'CYT 27-4.492-0. 206-5.949 1.00 0.00 H ATOM 7591 H3'CYT 27-2.616 2. 692-5.411 1.00 0.00 H ATOM 7592 P GUA 28-1.828 0. 229--6. 636 1. 00 0.00 P ATOM 7593 01P GUA 28-0.927-0. 932-6.463 1.00 0.00 0 ATOM 7594 02P GUA 28-1.316 1.474-7. 252 1.00 0.00 0 ATOM 7595 05'GUA 28-3.119-0. 251-7.475 1.00 0.00 O ATOM 7596 C5'GUA 28-3.509-1. 629-7.494 1. 00 0.00 C ATOM 7597 C4'GUA 28-4.308-1. 966-8.751 1. 00 0.00 C ATOM 7598 04'GUA 28-5. 530-1. 215-8.820 1. 00 0.00 0 ATOM 7599 C1'GUA 28-5.681-0. 658-10.138 1.00 0.00 c ATOM 7600 N9 GUA 28-5. 456 0.803-10. 127 1. oxo 0.00 N ATOM 7601 C4 GUA 28-6.030 1.733-10. 967 1.00 0. 00 c ATOM 7602 N3 GUA 28-6. 894 1.470-11. 974 1.00 0.00 N ATOM 7603 C2 GUA 28-7. 280 2.579-12. 612 1. 00 0. 00 C

ATOM 7604 N2 GUA 28-8.127 2.498-13. 638 1.00 0.00 N ATOM 7605 N1 GUA 28-6.845 3. 846-12.278 1.00 0.00 N ATOM 7606 C6 GUA 28-5.959 4.142-11. 250 1.00 0.00 C ATOM 7607 06 GUA 28-5.637 5.307-11. 031 1.00 0.00 0 ATOM 7608 C5 GUA 28-5.543 2.969-10. 567 1.00 0.00 C ATOM 7609 N7 GUA 28-4.668 2.827-9. 486 1.00 0.00 N ATOM 7610 C8 GUA 28-4.679 1.550-9. 304 1.00 0.00 C ATOM 7611 C2'GUA 28-4.653-1. 372-11.005 1. 00 0. 00 C ATOM 7612 02'GUA 28-5.160-2. 613-11.511 1.00 0.00 0 ATOM 7613 C3'GUA 28-3.535-1. 590-10.006 1.00 0.00 C ATOM 7614 03'GUA 28-2.756-2. 717-10.419 1.00 0.00 0 ATOM 7615 1H5'GUA 28-4.120-1. 840-6.617 1.00 0.00 H ATOM 7616 2H5'GUA 28-2.615-2. 252-7.464 1.00 0.00 H ATOM 7617 H4'GUA 28-4.536-3. 030-8.766 1.00 0.00 H ATOM 7618 H1'GUA 28-6.684-0. 871-10.511 1.00 0.00 H ATOM 7619 1H2 GUA 28-8.477 1.598-13. 933 1.00 0.00 H ATOM 7620 2H2 GUA 28-8.420 3.337-14. 119 1.00 0.00 H ATOM 7621 H1 GUA 28-7.188 4.635-12. 806 1.00 0.00 H ATOM 7622 H8 GUA 28-4.083 1.088-8. 517 1.00 0.00 H ATOM 7623 H2'GUA 28-4.321-0. 720-11.817 1.00 0.00 H ATOM 7624 H02'GUA 28-5.455-3. 129-10.757 1.00 0. 00 H ATOM 7625 H3'GUA 28-2.933-0. 691-9.865 1.00 0.00 H ATOM 7626 P CYT 29-1.400-2. 506-11.262 1.00 0.00 P ATOM 7627 01P CYT 29-0.638-1. 397-10.645 1.00 0.00 0 ATOM 7628 02P CYT 29-0.760-3. 828-11.449 1.00 0.00 0 ATOM 7629 05'CYT 29-1.952-2. 005-12.689 1.00 0.00 0 ATOM 7630 C5'CYT 29-2.591-2. 921-13.584 1.00 0.00 C ATOM 7631 C4'CYT 29-3.241-2. 197-14.760 1.00 0.00 C ATOM 7632 04'CYT 29-4.244-1. 274-14.321 1.00 0.00 0 ATOM 7633 C1'CYT 29-4.146-0. 055-15.082 1.00 0.00 C ATOM 7634 N1 CYT 29-3.736 1.081-14. 223 1.00 0.00 N ATOM 7635 C6 CYT 29-2.904 0.893-13. 156 1.00 0.00 C ATOM 7636 C2 CYT 29-4.241 2.338-14. 534 1.00 0.00 C ATOM 7637 02 CYT 29-4.983 2.487-15. 503 1.00 0.00 0 ATOM 7638 N3 CYT 29-3.887 3.389-13. 744 1.00 0.00 N ATOM 7639 C4 CYT 29-3.074 3.218-12. 694 1. 00 0.00 C ATOM 7640 N4 CYT 29-2.753 4.268-11. 939 1.00 0.00 N ATOM 7641 C5 CYT 29-2. 550 1.927-12. 370 1.00 0.00 C ATOM 7642 C2'CYT 29-3.119-0. 322-16.179 1.00 0.00 C ATOM 7643 02'CYT 29-3.737-0. 841-17.363 1.00 0.00 O ATOM 7644 C3'CYT 29-2.228-1. 354-15.515 1.00 0.00 C ATOM 7645 03'CYT 29-1. 625-2. 168-16. 527 1.00 0.00 0 ATOM 7646 1H5'CYT 29-3.357-3. 475-13.040 1.00 0.00 H ATOM 7647 2H5'CYT 29-1.848-3. 621-13.965 1.00 0. 00 H ATOM 7648 H4'CYT 29-3.690-2. 924-15.435 1.00 0.00 H ATOM 7649 H1'GYT 29-5.113 0.165-15. 538 1.00 0.00 H ATOM 7650 H6 CYT 29-2.522-0. 104-12.939 1.00 0.00 H ATOM 7651 1H4 CYT 29-2.142 4.149-11. 142 1.00 0.00 H ATOM 7652 2H4 CYT 29-3.118 5.182-12. 163 1.00 0.00 H ATOM 7653 H5 CYT 29-1.887 1.785-11. 517 1.00 0.00 H ATOM 7654 H2'CYT 29-2.554 0.586-16. 397 1.00 0.00 H ATOM 7655 H02'CYT 29-3. 034-1. 050-17.983 1.00 0.00 H ATOM 7656 H3'CYT 29-1. 495-0. 894-14. 850 1.00 0.00 H ATOM 7657 P CYT 30-0. 031-2. 146-16.762 1. 00 0.00 P ATOM 7658 01P CYT 30 0.619-1. 704-15.507 1.00 0. 00 0 ATOM 7659 02P CYT 30 0.363-3. 430-17.384 1. 00 0.00 0 ATOM 7660 05'CYT 30 0. 146-0. 978-17. 857 1. 00 0.00 0 ATOM 7661 C5'CYT 30-0.366-1. 140-19.184 1.00 0.00 C ATOM 7662 C4'CYT 30-0.922 0. 171-19.733 1. 00 0.00 C ATOM 7663 04'CYT 30-1.910 0.729-18. 859 1.00 0.00 0

ATOM 7664 C1'CYT 30-1.749 2.157-18. 807 1.00 0.00 C ATOM 7665 N1 CYT 30-1.348 2. 608-17. 455 1.00 0.00 N ATOM 7666 C6 CYT 30-0.492 1.868-16. 687 1.00 0.00 C ATOM 7667 C2 CYT 30-1.869 3.813-16. 999 1.00 0.00 C ATOM 7668 02 CYT 30-2.637 4.463-17. 706 1.00 0.00 0 ATOM 7669 N3 CYT 30-1.505 4.247-15. 762 1.00 0. 00 N ATOM 7670 C4 CYT 30-0.666 3.533-15. 001 1.00 0.00 C ATOM. 7671 N4 CYT 30-0.325 3.993-13. 798 1.00 0.00 N ATOM 7672 C5 CYT 30-0.128 2.291-15. 463 1.00 0.00 C ATOM 7673 C2'CYT 30-0.679 2.494-19. 843 1.00 0.00 C ATOM 7674 02'CYT 30-1.258 2.733-21. 133 1.00 0.00 0 ATOM 7675 C3'CYT 30 0.159 1.233-19. 835 1.00 0.00 C ATOM 7676 03'CYT 30 0.933 1.096-21. 032 1.00 0.00 0 ATOM 7677 1H5'CYT 30-1.162-1. 885-19.172 1.00 0.00 H ATOM 7678 2H5'CYT 30 0.437-1. 487-19.835 1. 00 0.00 H ATOM 7679 H4'CYT 30-1.363 0.001-20. 714 1.00 0.00 H ATOM 7680 H1'CYT 30-2.688 2.637-19. 087 1.00 0.00 H ATOM 7681 H6 CYT 30-0.103 0.924-17. 069 1.00 0.00 H ATOM 7682 1H4 CYT 30 0.308 3.464-13. 216 1.00 0.00 H ATOM 7683 2H4 CYT 30-0.694 4.874-13. 472 1.00 0. 00 H ATOM 7684 H5 CYT 30 0.554 1.707-14. 844 1.00 0.00 H ATOM 7685 H2'CYT 30-0.086 3.351-19. 512 1.00 0.00 H ATOM 7686 H02'CYT 30-1.857 2.007-21. 316 1.00 0.00 H ATOM 7687 H3'CYT 30 0.797 1.212-18. 946 1.00 0.00 H ATOM 7688 H03'CYT 30 0.336 1.221-21. 774 1.00 0.00 H TER ATOM 7689 05'GUA 1 5.078-3. 765-14.472 1.00 0.00 0 ATOM 7690 C5'GUA 1 6.017-3. 031-15.262 1.00 0.00 C ATOM 7691 C4'GUA 1 5.553-1. 597-15.500 1.00 0. 00 C ATOM 7692 04'GUA 1 4.288-1. 560-16.180 1.00 0.00 O ATOM 7693 C1'GUA 1 3.405-0. 647-15.506 1.00 0.00 C ATOM 7694 N9 GUA 1 2.364-1. 371-14.749 1.00 0.00 N ATOM 7695 C4 GUA 1 1.057-0. 978-14.566 1.00 0.00 C ATOM 7696 N3 GUA 1 0.501 0.163-15. 033 1.00 0.00 N ATOM 7697 C2 GUA 1-0.788 0.269-14. 698 1.00 0.00 C ATOM. 7698 N2 GUA 1-1.486 1.341-15. 072 1.00 0.00 N ATOM 7699 N1 GUA 1-1.469-0. 680-13.962 1. 00 0.00 N ATOM 7700 C6 GUA 1-0.920-1. 857-13.471 1.00 0.00 C ATOM 7701 06 GUA 1-1.614-2. 640-12. 826 1.00 0.00 0 ATOM 7702 C5 GUA 1 0.450-1. 978-13.822 1.00 0.00 C ATOM 7703 N7 GUA 1 1.362-2. 996-13.530 1.00 0.00 N ATOM 7704 C8 GUA 1 2.433-2. 561-14.102 1.00 0.00 C ATOM 7705 C2'GUA 1 4. 292 0. 170-14.581 1.00 0. 00 C ATOM 7706 02'GUA 1 4.887 1.278-15. 267 1.00 0.00 0 ATOM 7707 C3'GUA 1 5.324-0. 865-14.185 1. 00 0. 00 C ATOM 7708 03'GUA 1 6.531-0. 194-13.814 1.00 0.00 0 ATOM 7709 H5'GUA 1 5.090-3. 385-13.590 1.00 0.00 H ATOM 7710 1H5'GUA 1 6.139-3. 530-16.224 1.00 0.00 H ATOM 7711 2H5'GUA 1 6.978-3. 014-14.747 1.00 0.00 H ATOM 7712 H4'GUA 1 6.296-1. 063-16.091 1.00 0.00 H ATOM 7713 H1'GUA 1 2.934 0. 012-16. 237 1.00 0. 00 H ATOM 7714 1H2 GUA 1-1.040 2.072-15. 607 1.00 0.00 H ATOM 7715 2H2 GUA 1-2.462 1.419-14. 825 1.00 0.00 H ATOM 7716 H1 GUA 1-2.445-0. 530-13.758 1.00 0.00 H ATOM 7717 H8 GUA 1 3.363-3. 128-14.063 1.00 0. 00 H ATOM 7718 H2'GUA 1 3.726 0. 503-13.707 1.00 0.00 H ATOM 7719 H02'GUA 1 4.214 1.959-15. 345 1.00 0.00 H ATOM 7720 H3'GUA 1 4.954-1. 530-13.403 1. 00 0.00 H ATOM 7721 P GUA 2 6.724 0. 371-12. 318 1.00 0.00 P ATOM 7722 O1P GUA 2 6.381-0. 710-11.367 1.00 0. 00 O

ATOM 7723 02P GUA 2 8.047 1.031-12. 238 1.00 0.00 0 ATOM 7724 05'GUA 2 5.585 1.506-12. 222 1.00 0.00 0 ATOM 7725 C5'GUA 2 5.718 2.732-12. 949 1.00 0.00 C ATOM 7726 C4'GUA 2 4.438 3.562-12. 896 1.00 0.00 C ATOM 7727 04'GUA 2 3.322 2.860-13. 450 1.00 0.00 0 ATOM 7728 C1'GUA 2 2.134 3.184-12. 701 1.00 0.00 C ATOM 7729 N9 GUA 2 1.541 1. 977-12. 087 1.00 0.00 N ATOM 7730 C4 GUA 2 0.204 1.755-11. 842 1.00 0.00 C ATOM 7731 N3 GUA 2-0.806 2.611-12. 118 1.00 0.00 N ATOM 7732 C2 GUA 2-1. 998 2.118-11. 767 1.00 0.00 C ATOM 7733 N2 GUA 2-3.102 2.836-11. 969 1. 00 0.00 N ATOM 7734 N1 GUA 2-2. 173 0.876-11. 189 1.00 0.00 N ATOM 7735 C6 GUA 2-1.153-0. 019-10.895 1.00 0.00 C ATOM 7736 06 GUA 2-1.415-1. 102-10.375 1.00 0.00 O ATOM. 7737 C5 GUA 2 0.118 0.497-11. 265 1.00 0.00 C ATOM 7738 N7 GUA 2 1.387-0. 076-11.144 1.00 0.00 N ATOM 7739 C8 GUA 2 2. 141 0.845-11. 640 1.00 0. 00 C ATOM 7740 C2'GUA 2 2.560 4.193-11. 636 1.00 0.00 C ATOM 7741 02'GUA 2 2.373 5.541-12. 086 1.00 0.00 0 ATOM 7742 C3'GUA 2 4.029 3.859-11. 467 1.00 0.00 C ATOM 7743 03'GUA 2 4.724 5.029-11. 026 1. 00 0.00 0 ATOM 7744 1H5'GUA 2 5.952 2. 505-13. 989 1. 00 0.00 H ATOM 7745 2H5'GUA 2 6.535 3.311-12. 519 1.00 0.00 H ATOM 7746 H4'GUA 2 4. 582 4.496-13. 439 1.00 0.00 H ATOM 7747 H1'GUA 2 1.404 3.648-13. 365 1.00 0.00 H ATOM 7748 1H2 GUA 2-3.038 3.754-12. 387 1.00 0.00 H ATOM 7749 2H2 GUA 2-4.003 2.464-11. 705 1.00 0.00 H ATOM 7750 H1 GUA 2-3.108 0.574-10. 957 1.00 0.00 H ATOM 7751 H8 GUA 2 3.222 0.718-11. 699 1.00 0.00 H ATOM 7752 H2'GUA 2 2.019 4.012-10. 704 1.00 0.00 H ATOM 7753 H02'GUA 2 2.853 5.634-12. 912 1.00 0.00 H ATOM 7754 H3'GUA 2 4. 181 3.003-10. 808 1.00 0.00 H ATOM 7755 P CYT 3 5.060 5.238-9. 466 1.00 0.00 P ATOM 7756 01P CYT 3 5.911 6.442-9. 332 1.00 0.00 0 ATOM 7757 02P CYT 3 5.521 3.945-8. 913 1.00 0. 00 0 ATOM 7758 05'CYT 3 3.614 5.568-8. 839 1.00 0.00 O ATOM 7759 C5'CYT 3 3.052 6.876-8. 965 1.00 0.00 C ATOM 7760 C4'CYT 3 1.594 6.911-8. 516 1.00 0.00 C ATOM 7761 04'CYT 3 0.766 6.054-9. 314 1.00 0.00 O ATOM 7762 C1'CYT 3-0.202 5.404-8. 465 1.00 0.00 C ATOM 7763 N1 CYT 3 0.033 3.944-8. 397 1.00 0.00 N ATOM 7764 C6 CYT 3 1.300 3.436-8. 377 1.00 0.00 C ATOM 7765 C2 CYT 3-1.079 3.115-8. 337 1.00 0.00 C ATOM 7766 02 CYT 3-2.210 3.597-8. 354 1.00 0.00 0 ATOM 7767 N3 CYT 3-0.879 1.771-8. 254 1.00 0.00 N ATOM 7768 C4 CYT 3 0.359 1.260-8. 231 1.00 0.00 C ATOM 7769 N4 CYT 3 0.518-0. 062-8.145 1.00 0.00 N ATOM 7770 C5 CYT 3 1.508 2.111-8. 295 1.00 0.00 C ATOM 7771 C2'CYT 3-0.042 6.046-7. 089 1.00 0.00 C ATOM 7772 02'CYT 3-0.853 7.220-6. 959 1.00 0.00 0 ATOM 7773 C3'CYT 3 1.433 6.382-7. 103 1.00 0.00 C ATOM 7774 03'CYT 3 1.679 7.443-6. 176 1.00 0.00 O ATOM 7775 1H5'CYT 3 3.110 7.191-10. 007 1.00 0.00 H ATOM 7776 2H5'CYT 3 3.628 7.570-8. 352 1.00 0.00 H ATOM 7777 H4'CYT 3 1.215 7.930-8. 572 1.00 0. 00 H ATOM 7778 HI'CYT 3-1.206 5.597-8. 843 1.00 0.00 H ATOM 7779 H6 CYT 3 2.154 4.111-8. 435 1.00 0.00 H ATOM 7780 1H4 CYT 3 1.446-0. 458-8.125 1.00 0.00 H ATOM 7781 2H4 CYT 3-0.290-0. 666-8.095 1.00 0.00 H ATOM 7782 H5 CYT 3 2.516 1.702-8. 269 1.00 0. 00 H

ATOM 7783 H2'CYT 3-0.264 5.322-6. 302 1.00 0.00 H ATOM 7784 H02'CYT 3-1.770 6.938-6. 986 1.00 0.00 H ATOM 7785 H3'CYT 3 2.055 5.502-6. 918 1.00 0.00 H ATOM 7786 P GUA 4 2.175 7.116-4. 678 1.00 0.00 P ATOM 7787 01P GUA 4 3.282 6.137-4. 760 1.00 0.00 O ATOM 7788 02P GUA 4 2.376 8.398-3. 966 1.00 0.00 O ATOM 7789 05'GUA 4 0.895 6.377-4. 039 1.00 0.00 0 ATOM 7790 C5'GUA 4-0.295 7.112-3. 741 1.00 0.00 C ATOM 7791 C4'GUA 4-1.448 6.189-3. 355 1.00 0.00 C ATOM 7792 04'GUA 4-1.750 5.250-4. 385 1.00 0.00 O ATOM 7793 C1'GUA 4-2.273 4.049-3. 784 1.00 0.00 C ATOM 7794 N9 GUA 4-1.548 2.849-4. 251 1.00 0.00 N ATOM 7795 C4 GUA 4-1.856 1.541-3. 950 1.00 0.00 C ATOM 7796 N3 GUA 4-2.864 1. 131-3. 149 1.00 0.00 N ATOM 7797 C2 GUA 4-2.917-0. 199-3.045 1.00 0.00 C ATOM 7798 N2 GUA 4-3.843-0. 767-2.273 1.00 0.00 N ATOM 7799 N1 GUA 4-2.042-1. 054-3.688 1.00 0.00 N ATOM 7800 C6 GUA 4-1.000-0. 656-4.516 1.00 0.00 C ATOM 7801 06 GUA 4-0.279-1. 496-5.048 1.00 0.00 O ATOM 7802 C5 GUA 4-0.935 0.759-4. 628 1.00 0.00 C ATOM 7803 N7 GUA 4-0.047 1.559-5. 351 1.00 0.00 N ATOM 7804 C8 GUA 4-0.475 2.745-5. 073 1.00 0.00 C ATOM 7805 C2'GUA 4-2. 133 4. 221-2. 268 1.00 0.00 C ATOM 7806 02'GUA 4-3.376 4.608-1. 671 1.00 0.00 0 ATOM 7807 C3'GUA 4-1.095 5.325-2. 163 1.00 0.00 C ATOM 7808 03'GUA 4-1.336 6.070-0. 965 1.00 0.00 0 ATOM 7809 1H5'GUA 4-0.584 7.692-4. 618 1.00 0.00 H ATOM 7810 2H5'GUA 4-0.094 7.793-2. 914 1.00 0.00 H ATOM 7811 H4'GUA 4-2.336 6.779-3. 132 1.00 0.00 H ATOM 7812 H1'GUA 4-3.329 3.953-4. 037 1.00 0.00 H ATOM 7813 1H2 GUA 4-4. 503-0.192-1. 770 1.00 0. 00 H ATOM 7814 2H2 GUA 4-3.885-1. 771-2.191 1.00 0.00 H ATOM 7815 Hl GUA 4-2.154-2. 050-3.568 1.00 0.00 H ATOM 7816 H8 GUA 4 0.014 3.628-5. 477 1.00 0.00 H ATOM 7817 H2'GUA 4-1.753 3.300-1. 818 1.00 0.00 H ATOM 7818 H02'GUA 4-3.953 3.841-1. 688 1.00 0.00 H ATOM 7819 H3'GUA 4-0.077 4.937-2. 222 1. 00 0.00 H ATOM 7820 P CYT 5-0. 783 5.540 0.451 1.00 0.00 P ATOM 7821 01P CYT 5 0.649 5.201 0.291 1.00 0.00 0 ATOM 7822 02P CYT 5-1.202 6.498 1.499 1.00 0.00 O ATOM 7823 05'CYT 5-1.603 4.168 0.659 1.00 0. 00 0 ATOM 7824 C5'CYT 5-2.913 4.177 1.236 1.00 0. 00 C ATOM 7825 C4'CYT 5-3.326 2.785 1. 707 1.00 0.00 C ATOM 7826 04'CYT 5-3.443 1. 867 0.613 1.00 0.00 0 ATOM 7827 C1'CYT 5-2.876 0.595 0.984 1.00 0.00 C ATOM 7828 N1 CYT 5-1.671 0.291 0.178 1.00 0.00 N ATOM 7829 C6 CYT 5-0.835 1.287-0. 235 1.00 0.00 C ATOM 7830 C2 CYT 5-1.431-1. 039-0.148 1.00 0. 00 C ATOM 7831 02 CYT 5-2.197-1. 921 0.237 1.00 0.00 0 ATOM 7832 N3 CYT 5-0.332-1. 330-0.897 1.00 0.00 N ATOM 7833 C4 CYT 5 0.496-0. 362-1.309 1.00 0.00 C ATOM 7834 N4 CYT 5 1.563-0. 682-2. 041 1.00 0.00 N ATOM 7835 C5 CYT 5 0.253 1.006-0. 975 1.00 0.00 C ATOM 7836 C2'CYT 5-2.536 0.699 2.468 1.00 0.00 C ATOM 7837 02'CYT 5-3.632 0.274 3.289 1.00 0.00 0 ATOM 7838 C3'CYT 5-2.269 2.183 2.616 1.00 0.00 C ATOM 7839 03'CYT 5-2.550 2.575 3.964 1.00 0.00 0 ATOM 7840 1H5'CYT 5-3. 629 4.528 0.493 1.00 0.00 H ATOM 7841 2H5'CYT 5-2.921 4.856 2.088 1.00 0.00 H ATOM 7842 H4'CYT 5-4.276 2.841 2.235 1.00 0.00 H

ATOM 7843 H1'CYT 5-3.618-0. 189 0.838 1.00 0.00 H ATOM 7844 H6 CYT 5-1.049 2.320 0.037 1.00 0.00 H ATOM 7845 1H4 CYT 5 1.741-1. 646-2.281 1.00 0.00 H ATOM 7846 2H4 CYT 5 2.193 0.042-2. 357 1.00 0.00 H ATOM 7847 H5 CYT 5 0.927 1.795-1. 305 1.00 0.00 H ATOM 7848 H2'CYT 5-1.633 0. 126 2.689 1.00 0.00 H ATOM 7849 H02'CYT 5-3.656-0. 685 3.258 1.00 0.00 H ATOM 7850 H3'CYT 5-1.258 2.448 2.303 1.00 0.00 H ATOM 7851 P URI 6-1.362 2.704 5.044 1.00 0. 00 P ATOM 7852 O1P URI 6-0.208 3.360 4.388 1.00 0.00 0 ATOM 7853 02P URI 6-1.926 3.274 6.288 1.00 0.00 0 ATOM 7854 05'URI 6-0.974 1.166 5.321 1.00 0.00 0 ATOM 7855 C5'URI 6-1.863 0.314 6.049 1.00 0.00 C ATOM 7856 C4'URI 6-1.583-1. 161 5.772 1.00 0.00 C ATOM 7857 04'URI 6-1.702-1. 469 4.376 1.00 0.00 0 ATOM 7858 C1'URI 6-0.644-2. 373 3.994 1.00 0.00 C ATOM 7859 N1 URI 6 0.319-1. 726 3.074 1.00 0.00 N ATOM 7860 C6 URI 6 0.682-0. 415 3.235 1.00 0.00 C ATOM 7861 C2 URI 6 0.852-2. 501 2.059 1.00 0.00 C ATOM 7862 02 URI 6 0.540-3. 679 1.899 1.00 0.00 0 ATOM 7863 N3 URI 6 1.763-1. 875 1.232 1.00 0.00 N ATOM 7864 C4 URI 6 2.185-0. 561 1.325 1.00 0.00 C ATOM 7865 04 URI 6 3.009-0. 111 0.532 1.00 0.00 0 ATOM 7866 C5 URI 6 1.579 0.175 2.409 1.00 0.00 C ATOM 7867 C2'URI 6 0.037-2. 784 5.293 1.00 0.00 C ATOM 7868 02'URI 6-0.603-3. 921 5.885 1.00 0.00 0 ATOM 7869 C3'URI 6-0.155-1. 536 6.127 1.00 0.00 C ATOM 7870 03'URI 6-0.093-1. 891 7.511 1.00 0.00 O ATOM 7871 1H5'URI 6-2. 890 0.540 5.762 1.00 0.00 H ATOM 7872 2H5'URI 6-1.742 0.504 7.116 1.00 0.00 H ATOM 7873 H4'URI 6-2.277-1. 780 6.337 1. 00 0.00 H ATOM 7874 H1'URI 6-1.074-3. 253 3.514 1.00 0.00 H ATOM 7875 H6 URI 6 0.238 0.166 4.041 1.00 0.00 H ATOM 7876 H3 URI 6 2.156-2. 429 0.487 1.00 0.00 H ATOM 7877 H5 URI 6 1.847 1.221 2.565 1.00 0.00 H ATOM 7878 H2'URI 6 1.098-2. 971 5.122 1.00 0.00 H ATOM 7879 H02'URI 6-1.540-3. 722 5.946 1.00 0.00 H ATOM 7880 H3'URI 6 0.556-0. 752 5.861 1.00 0.00 H ATOM 7881 P CYT 7 1.328-1. 966 8. 267 1.00 0.00 P ATOM 7882 01P CYT 7 1.076-2. 254 9.697 1.00 0.00 0 ATOM 7883 02P CYT 7 2.121-0. 777 7.882 1.00 0.00 0 ATOM 7884 05'CYT 7 2.013-3. 264 7.602 1.00 0.00 0 ATOM 7885 C5'CYT 7 1.504-4. 573 7.875 1.00 0.00 C ATOM 7886 C4'CYT 7 2.104-5. 623 6.943 1. 00 0. 00 C ATOM 7887 04'CYT 7 1. 881-5. 308 5.566 1.00 0.00 O ATOM 7888 C1'CYT 7 3.009-5. 762 4.788 1.00 0.00 C ATOM 7889 N1 CYT 7 3.651-4. 648 4.053 1.00 0.00 N ATOM 7890 C6 CYT 7 3.564-3. 359 4.501 1.00 0.00 C ATOM 7891 C2 CYT 7 4.347-4. 964 2.893 1.00 0.00 C ATOM 7892 02 CYT 7 4.414-6. 131 2.509 1.00 0.00 O ATOM 7893 N3 CYT 7 4.947-3. 956 2.204 1.00 0.00 N ATOM 7894 C4 CYT 7 4.870-2. 690 2.630 1.00 0.00 C ATOM 7895 N4 CYT 7 5.467-1. 728 1.928 1.00 0. 00 N ATOM 7896 C5 CYT 7 4.155-2. 356 3.824 1.00 0. 00 C ATOM 7897 C2'CYT 7 3.984-6. 396 5. 781 1.00 0.00 C ATOM 7898 02'CYT 7 3.782-7. 812 5.881 1.00 0.00 O ATOM 7899 C3'CYT 7 3.613-5. 687 7.068 1.00 0.00 C ATOM 7900 03'CYT 7 3.953-6. 528 8.175 1.00 0. 00 0 ATOM 7901 1H5'CYT 7 0.421-4. 567 7.749 1.00 0. 00 H ATOM 7902 2H5'CYT 7 1.740-4. 838 8. 906 1.00 0.00 H

ATOM 7903 H4'CYT 7 1. 676-6. 600 7.163 1.00 0. 00 H ATOM 7904 H1'CYT 7 2. 674-6. 520 4.079 1.00 0. 00 H ATOM 7905 H6 CYT 7 3.012-3. 140 5.415 1.00 0.00 H ATOM 7906 1H4 CYT 7 5.414-0. 768 2.239 1.00 0.00 H ATOM 7907 2H4 CYT 7 5.973-1. 958 1.084 1. 00 0.00 H ATOM 7908 H5 CYT 7 4.091-1. 326 4.174 1.00 0.00 H ATOM 7909 H2'CYT 7 5.014-6. 165 5.499 1.00 0.00 H ATOM 7910 H02'CYT 7 2.853-7. 955 6.074 1.00 0.00 H ATOM 7911. H3'CYT 7 4.065-4. 695 7.134 1.00 0.00 H ATOM 7912 P ADE 8 5.393-6. 398 8.885 1.00 0.00 P ATOM 7913 O1P ADE 8 5.591-4. 984 9.276 1.00 0.00 0 ATOM 7914 02P ADE 8 5.507-7. 467 9.902 1.00 0.00 0 ATOM 7915 05'ADE 8 6.410-6. 734 7.682 1.00 0.00 0 ATOM 7916 C5'ADE 8 6.563-8. 076 7.211 1.00 0.00 C ATOM 7917 C4'ADE 8 7.432-8. 138 5.958 1.00 0.00 C ATOM 7918 04'ADE 8 6.850-7. 399 4.870 1.00 0.00 0 ATOM 7919 C1'ADE 8 7.867-6. 593 4.244 1.00 0. 00 C ATOM 7920 N9 ADE 8 7.702-5. 163 4.582 1.00 0.00 N ATOM 7921 C4 ADE 8 8.188-4. 085 3.873 1.00 0.00 C ATOM 7922 N3 ADE 8 8.901-4. 132 2.729 1. 00 0.00 N ATOM 7923 C2 ADE 8 9. 216-2. 911 2.305 1.00 0.00 C ATOM 7924 N1 ADE 8 8.902-1. 750 2.883 1.00 0.00 N ATOM 7925 C6 ADE 8 8.190-1. 729 4.023 1.00 0.00 C ATOM 7926 N6 ADE 8 7.884-0. 559 4.584 1.00 0.00 N ATOM 7927 C5 ADE 8 7.802-2. 959 4.563 1.00 0.00 C ATOM 7928 N7 ADE 8 7.074-3. 301 5.706 1.00 0.00 N ATOM 7929 C8 ADE 8 7.068-4. 589 5.635 1.00 0.00 C ATOM 7930 C2'ADE 8 9.186-7. 131 4.773 1.00 0.00 C ATOM 7931 02'ADE 8 9.622-8. 282 4.040 1.00 0. 00 0 ATOM 7932 C3'ADE 8 8.787-7. 486 6.188 1. 00 0.00 C ATOM 7933 03'ADE 8 9.701-8. 461 6. 701 1.00 0.00 0 ATOM 7934 1H5'ADE 8 5.581-8. 489 6.983 1.00 0.00 H ATOM 7935 2H5'ADE 8 7. 028-8. 675 7.995 1. DO 0.00 H ATOM 7936 H4'ADE 8 7.570-9. 175 5.656 1. 00 0.00 H ATOM 7937 H1'ADE 8 7.828-6. 724 3.164 1.00 0.00 H ATOM 7938 H2 ADE 8 9.796-2. 851 1.384 1.00 0.00 H ATOM 7939 1H6 ADE 8 8.189 0.302 4.153 1.00 0.00 H ATOM 7940 2H6 ADE 8 7.348-0. 534 5.439 1.00 0.00 H ATOM 7941 H8 ADE 8 6.577-5. 194 6.397 1.00 0.00 H ATOM 7942 H2'ADE 8 9.944-6. 346 4.769 1.00 0.00 H ATOM 7943 H02'ADE 8 10.321-8. 696 4.550 1.00 0.00 H ATOM 7944 H3'ADE 8 8.712-6. 603 6.821 1.00 0.00 H ATOM 7945 P ADE 9 10.039-8. 520 8.278 1. 00 0.00 P ATOM 7946 O1P ADE 9 11.239-9. 366 8.462 1. 00 0.00 0 ATOM 7947 02P ADE 9 8.792-8. 840 9.009 1.00 0.00 0 ATOM 7948 05'ADE 9 10.442-6. 994 8.614 1. 00 0.00 0 ATOM 7949 C5'ADE 9 10.957-6. 641 9.906 1.00 0.00 C ATOM 7950 C4'ADE 9 10.955-5. 125 10.128 1.00 0.00 C ATOM 7951 04'ADE 9 11.706-4. 446 9.119 1.00 0.00 0 ATOM 7952 C1'ADE 9 10.807-3. 823 8.184 1.00 0.00 C ATOM 7953 N9 ADE 9 11. 186-4. 163 6.802 1.00 0.00 N ATOM 7954 C4 ADE 9 11.430-3. 282 5.778 1.00 0. 00 C ATOM 7955 N3 ADE 9 11.332-1. 943 5.842 1.00 0.00 N ATOM 7956 C2 ADE 9 11.640-1. 382 4.680 1.00 0.00 C ATOM 7957 N1 ADE 9 12.005-2. 000 3.556 1. 00 0.00 N ATOM 7958 C6 ADE 9 12.096-3. 340 3.517 1.00 0. 00 C ATOM 7959 N6 ADE 9 12.463-3. 939 2.385 1.00 0. 00 N ATOM 7960 C5 ADE 9 11.794-4. 038 4.689 1.00 0.00 C ATOM 7961 N7 ADE 9 11.783-5. 399 5. 006 1. off 0. 00 N ATOM 7962 C8 ADE 9 11.419-5. 372 6.244 1.00 0.00 C

ATOM 7963 C2'ADE 9 9.417-4. 346 8.529 1.00 0.00 C ATOM 7964 02'ADE 9 8.395-3. 395 8.209 1.00 0.00 0 ATOM 7965 C3'ADE 9 9.551-4. 547 10.022 1.00 0.00 C ATOM 7966 03'ADE 9 9.527-3. 252 10.639 1.00 0.00 0 ATOM 7967 1H5'ADE 9 11. 979-7. 010 9.992 1.00 0.00 H ATOM 7968 2H5'ADE 9 10.344-7. 113 10.674 1.00 0.00 H ATOM 7969 H4'ADE 9 11.377-4. 899 11.106 1.00 0.00 H ATOM 7970 H1'ADE 9 10.830-2. 741 8.317 1.00 0.00 H ATOM 7971 H2 ADE 9 11.600-0. 298 4.646 1.00 0.00 H ATOM 7972 1H6 ADE 9 12.534-4. 946 2.347 1.00 0.00 H ATOM 7973 2H6 ADE 9 12.671-3. 387 1.565 1.00 0.00 H ATOM 7974 H8 ADE 9 11.297-6. 289 6.818 1.00 0.00 H ATOM 7975 H2'ADE 9 9.239-5. 302 8.038 1.00 0.00 H ATOM 7976 H02'ADE 9 8.607-2. 582 8.674 1.00 0.00 H ATOM 7977 H3'ADE 9 8.796-5. 219 10.421 1.00 0.00 H ATOM 7978 P URI 10 9.867-3. 035 12.200 1.00 0.00 P ATOM 7979 O1P URI 10 11.094-3. 796 12.529 1.00 0.00 0 ATOM 7980 02P URI 10 8.629-3. 253 12.981 1.00 0.00 0 ATOM 7981 05'URI 10 10.219-1. 465 12.236 1.00 0.00 0 ATOM 7982 C5'URI 10 11.342-0. 969 12.971 1.00 0.00 C ATOM 7983 C4'URI 10 12.337-0. 262 12.049 1.00 0.00 C ATOM 7984 04'URI 10 11.674 0.588 11.110 1.00 0.00 0 ATOM 7985 C1'URI 10 11.739 1.954 11.559 1.00 0.00 C ATOM 7986 N1 URI 10 10.385 2.544 11.643 1.00 0.00 N ATOM 7987 C6 URI 10 9.268 1.757 11.537 1.00 0.00 C ATOM 7988 C2 URI 10 10.288 3.913 11.828 1.00 0.00 C ATOM 7989 02 URI 10 11.278 4.635 11.925 1.00 0.00 0 ATOM 7990 N3 URI 10 9.005 4.426 11.897 1.00 0.00 N ATOM 7991 C4 URI 10 7.829 3.703 11.799 1.00 0.00 C ATOM 7992 04 URI 10 6.739 4. 266 11.874 1. O0 0. 00 ATOM 7993 C5 URI 10 8.024 2.283 11.608 1.00 0.00 C ATOM 7994 C2'URI 10 12.418 1.922 12.929 1.00 0.00 C ATOM 7995 02'URI 10 13.231 3.082 13.144 1.00 0.00 O ATOM 7996 C3'URI 10 13.257 0.661 12.830 1.00 0.00 C ATOM 7997 03'URI 10 14.409 0.943 12.024 1.00 0.00 0 ATOM 7998 1H5'URI 10 11.844-1. 797 13.472 1.00 0.00 H ATOM 7999 2H5'URI 10 10.987-0. 262 13.721 1.00 0.00 H ATOM 8000 H4'URI 10 12.927-1. 002 11.512 1.00 0.00 H ATOM 8001 H1'URI 10 12.347 2.535 10.865 1.00 0.00 H ATOM 8002 H6 URI 10 9.384 0.683 11.389 1.00 0.00 H ATOM 8003 H3 URI 10 8.918 5.423 12.031 1.00 0.00 H ATOM 8004 H5 URI 10 7.159 1.627 11.520 1.00 0.00 H ATOM 8005 H2'URI 10 11.668 1.812 13.718 1.00 0. 00 H ATOM 8006 H02'URI 10 12.655 3.849 13.087 1.00 0.00 H ATOM 8007 H3'URI 10 13.518 0.256 13.808 1.00 0.00 H ATOM 8008 P GUA 11 15.604-0. 130 11.883 1.00 0.00 P ATOM 8009 01P GUA 11 15.961-0. 609 13.238 1.00 0.00 0 ATOM 8010 02P GUA 11 16.647 0.453 11.009 1.00 0.00 0 ATOM 8011 05'GUA 11 14.899-1. 340 11.085 1.00 0.00 0 ATOM 8012 C5'GUA 11 15.229-2. 702 11.379 1.00 0.00 C ATOM 8013 C4'GUA 11 15.355-3. 539 10.108 1.00 0.00 C ATOM 8014 04'GUA 11 14.133-3. 545 9.353 1.00 0.00 0 ATOM 8015 C1'GUA 11 14.426-3. 287 7.967 1.00 0.00 C ATOM 8016 N9 GUA 11 14.052-1. 913 7.592 1.00 0.00 N ATOM 8017 C4 GUA 11 14.247-1. 316 6.369 1.00 0.00 C ATOM 8018 N3 GUA 11 14.809-1. 898 5.286 1.00 0.00 N ATOM 8019 C2 GUA 11 14.863-1. 070 4.240 1. 00 0.00 C ATOM 8020 N2 GUA 11 15.384-1. 488 3.088 1.00 0.00 N ATOM 8021 N1 GUA 11 14.398 0.229 4.268 1.00 0.00 N ATOM 8022 C6 GUA 11 13.818 0.849 5.367 1.00 0.00 C

ATOM 8023 06 GUA 11 13.437 2.014 5.288 1.00 0.00 0 ATOM 8024 C5 GUA 11 13.756-0. 025 6.484 1.00 0.00 C ATOM 8025 N7 GUA 11 13.252 0.196 7.769 1.00 0.00 N ATOM 8026. C8 GUA 11 13.465-0. 945 8.333 1.00 0.00 C ATOM'8027 C2'GUA 11 15.928-3. 495 7. 830 1.00 0.00 C ATOM 8028 02'GUA 11 16.259-4. 880 7.665 1.00 0.00 O ATOM 8029 C3'GUA 11 16.397-2. 958 9.166 1.00 0.00 C ATOM 8030 03'GUA 11 17.673-3. 526 9.476 1.00 0.00 0 ATOM 8031 1H5'GUA 11 14.449-3. 129 12.010 1.00 0.00 H ATOM 8032 2H5'GUA 11 16.177-2. 731 11.918 1.00 0.00 H ATOM 8033 H4'GUA 11 15.625-4. 562 10.367 1.00 0.00 H ATOM 8034 Hl'GUA 11 13.889-3. 998 7.336 1.00 0.00 H ATOM 8035 1H2 GUA 11 15.425-0. 864 2.296 1.00 0.00 H ATOM 8036 2H2 GUA 11 15.738-2. 431 3.006 1.00 0. 00'H ATOM 8037 H1 GUA 11 14.476 0.792 3.433 1.00 0.00 H ATOM 8038 H8 GUA 11 13.181-1. 127 9.367 1.00 0.00 H ATOM 8039 H2'GUA 11 16.325-2. 889 7.011 1.00 0. 00 H ATOM 8040 H02'GUA 11 15.962-5. 141 6.791 1.00 0.00 H ATOM 8041 H3'GUA 11 16.405-1. 867 9.185 1.00 0.00 H ATOM 8042 P CYT 12 19.006-2. 631 9.363 1.00 0.00 P ATOM 8043 01P CYT 12 18.766-1. 349 10.063 1.00 0.00 0 ATOM 8044 02P CYT 12 20.164-3. 473 9.740 1.00 0.00 0 ATOM 8045 05'CYT 12 19.090-2. 335 7.783 1.00 0.00 0 ATOM 8046 C5'CYT 12 19.429-3. 380 6.869 1.00 0.00 C ATOM 8047 C4'CYT 12 19.468-2. 880 5.428 1.00 0.00 C ATOM 8048 04'CYT 12 18.193-2. 394 4.996 1.00 0.00 0 ATOM 8049 C1'CYT 12 18.381-1. 228 4.168 1.00 0.00 C ATOM 8050 N1 CYT 12 17.785-0. 023 4.789 1.00 0.00 N ATOM 8051 C6 CYT 12 17.349-0. 041 6.085 1.00 0.00 C ATOM 8052 C2 CYT 12 17.672 1.118 4.003 1.00 0.00 C ATOM 8053 02 CYT 12 18.084 1.118 2.844 1.00 0.00 0 ATOM 8054 N3 CYT 12 17.108 2.227 4.555 1.00 0.00 N ATOM 8055 C4 CYT 12 16.675 2.222 5.821 1.00 0.00 C ATOM 8056 N4 CYT 12 16.115 3.321 6.324 1.00 0.00 N ATOM 8057 C5 CYT 12 16.793 1.053 6.636 1.00 0.00 C ATOM 8058 C2'CYT 12 19.891-1. 073 3.995 1.00 0.00 C ATOM 8059 02'CYT 12 20.360-1. 776 2.840 1.00 0.00 O ATOM 8060 C3'CYT 12 20.401-1. 694 5.278 1.00 0.00 C ATOM 8061 03'CYT 12 21.729-2. 181 5.068 1.00 0.00 O ATOM 8062 1H5'CYT 12 18.690-4. 177 6.948 1.00 0.00 H ATOM 8063 2H5'CYT 12 20.410-3. 777 7.132 1.00 0.00 H ATOM 8064 H4'CYT 12 19.789-3. 685 4.768 1.00 0.00 H ATOM 8065 H1'CYT 12 17.923-1. 399 3.193 1.00 0.00 H ATOM 8066 H6 CYT 12 17.447-0. 951 6.678 1.00 0.00 H ATOM 8067 1H4 CYT 12 15.778 3.327 7.276 1.00 0.00 H ATOM 8068 2H4 CYT 12 16.025 4.149 5.751 1.00 0.00 H ATOM 8069 H5 CYT 12 16.447 1.048 7.668 1.00 0.00 H ATOM 8070 H2'CYT 12 20.160-0. 015 3.949 1. 00 0.00 H ATOM 8071 H02'CYT 12 19.939-1. 378 2.076 1.00 0.00 H ATOM 8072 H3'CYT 12 20.333-1. 002 6.119 1.00 0.00 H ATOM 8073 P URI 13 22.997-1. 310 5.538 1.00 0.00 P ATOM 8074 O1P URI 13 24.220-2. 115 5.325 1.00 0.00 O ATOM 8075 02P URI 13 22.705-0. 749 6.877 1.00 0. 00 O ATOM 8076 05'URI 13 22. 994-0. 103 4.475 1. 00 0. 00 0 ATOM 8077 C5'URI 13 23.301-0. 349 3.100 1.00 0. 00 C ATOM 8078 C4'URI 13 23.026 0.877 2.235 1.00 0.00 C ATOM 8079 04'URI 13 21.641 1.233 2.238 1.00 0.00 O ATOM 8080 C1'URI 13 21.519 2.670 2.209 1.00 0.00 C ATOM 8081 N1 URI 13 20.820 3.180 3.411 1.00 0.00 N ATOM 8082 C6 URI 13 20.776 2.449 4.571 1.00 0. 00 C

ATOM 8083 C2 URI 13 20.203 4.415 3.313 1.00 0. 00 C ATOM 8084 02 URI 13 20.239 5.088 2.284 1.00 0.00 0 ATOM 8085 N3 URI 13 19.543 4.856 4.444 1.00 0.00 N ATOM 8086 C4 URI 13 19.446 4.183 5.648 1.00 0.00 C ATOM 8087 04 URI 13 18.819 4.668 6.587 1.00 0.00 0 ATOM 8088 C5 URI 13 20.121 2.905 5.665 1.00 0.00 C ATOM 8089 C2'URI 13 22.943 3.217 2.126 1.00 0.00 C ATOM 8090 02'URI 13 23.347 3.429 0.768 1.00 0.00 0 ATOM 8091 C3'URI 13 23.733 2.102 2.779 1.00 0.00 C ATOM 8092 03'URI 13 25.072 2.122 2.277 1. 00 0. 00 O ATOM 8093 1H5'URI 13 22.693-1. 180 2.741 1.00 0.00 H ATOM 8094 2H5'URI 13 24.355-0. 615 3.014 1.00 0.00 H ATOM 8095 H4'URI 13 23. 349 0.688 1.213 1.00 0.00 H ATOM 8096 H1'URI 13 20.967 2.966 1.316 1.00 0.00 H ATOM 8097 H6 URI 13 21.285 1.486 4.617 1.00 0.00 H ATOM 8098 H3 URI 13 19.092 5.757 4.386 1.00 0. 00 H ATOM 8099 H5 URI 13 20. 103 2.299 6.572 1.00 0.00 H ATOM 8100 H2'URI 13 23.029 4.136 2.710 1.00 0.00 H ATOM 8101 H02'URI 13 22.882 4.206 0.450 1.00 0.00 H ATOM 8102 H3'URI 13 23.689 2.153 3.868 1.00 0.00 H ATOM 8103 P CYT 14 26.198 3.021 2.997 1.00 0.00 P ATOM 8104 01P CYT 14 26.030 2.887 4.462 1.00 0. 00 0 ATOM 8105 02P CYT 14 27.505 2.716 2.373 1.00 0.00 0 ATOM 8106 05'CYT 14 25.771 4.514 2.577 1.00 0.00 O ATOM 8107 C5'CYT 14 25.956 4.974 1.235 1.00 0.00 C ATOM 8108 C4'CYT 14 25.374 6.369 1.037 1. 00 0. 00 C ATOM 8109 04'CYT 14 23.965 6.393 1.277 1.00 0.00 0 ATOM 8110 C1'CYT 14 23.608 7.630 1.926 1.00 0.00 C ATOM 8111 N1 CYT 14 23.002 7.391 3.254 1.00 0.00 N ATOM 8112 C6 CYT 14 23.329 6.288 3. 991 1.00 0.00 C ATOM 8113 C2 CYT 14 22.090 8.328 3.721 1.00 0.00 C ATOM 8114 02 CYT 14 21.817 9.318 3.045 1.00 0.00 O ATOM 8115 N3 CYT 14 21.519 8. 122 4.939 1.00 0. 00 N ATOM 8116 C4 CYT 14 21. 829 7.045 5.671 1.00 0.00 C ATOM 8117 N4 CYT 14 21.247 6.871 6. 856 1.00 0.00 N ATOM 8118 C5 CYT 14 22.770 6.079 5. 196 1.00 0.00 C ATOM 8119 C2'CYT 14 24.898 8.439 2.052 1.00 0.00 C ATOM 8120 02'CYT 14 25.058 9.346 0.955 1.00 0. 00 O ATOM 8121 C3'CYT 14 25.954 7.351 2.036 1.00 0.00 C ATOM 8122 03'CYT 14 27.165 7.890 1.499 1.00 0. 00 O ATOM 8123 1H5'CYT 14 25.466 4.283 0.549 1.00 0.00 H ATOM 8124 2H5'CYT 14 27.024 4.999 1.013 1.00 0.00 H ATOM 8125 H4'CYT 14 25. 575 6.713 0.023 1.00 0.00 H . ATOM 8126 H1'CYT 14 22. 902 8.175 1.298 1.00 0. 00 H ATOM 8127 H6 CYT 14 24.049 5.570 3.599 1.00 0. 00 H ATOM 8128 1H4 CYT 14 21.470 6.059 7.414 1.00 0.00 H ATOM 8129 2H4 CYT 14 20. 586 7.554 7. 199 1.00 0.00 H ATOM 8130 H5 CYT 14 23.031 5.206 5.792 1.00 0.00 H ATOM 8131 H2'CYT 14 24. 915 8.970 3.007 1. 00 0.00 H ATOM 8132 H02'CYT 14 24.992 8.832 0.147 1. 00 0.00 H ATOM 8133 H3'CYT 14 26.093 6.902 3.021 1.00 0.00 H ATOM 8134 P URI 15 28. 273 8.535 2.472 1.00 0.00 P ATOM 8135 01P URI 15 28.560 7.568 3.555 1. 00 0.00 0 ATOM 8136 02P URI 15 29. 378 9.056 1.635 1.00 0.00 O ATOM 8137 05'URI 15 27.490 9.788 3.111 1.00 0.00 0 ATOM 8138 C5'URI 15 27.254 10.971 2.343 1. 00 0.00 C ATOM 8139 C4'URI 15 26.337 11.944 3.079 1.00 0. 00 C ATOM 8140 04'URI 15 25.044 11.374 3.329 1.00 0.00 0 ATOM 8141 C1'URI 15 24. 630 11.695 4.673 1. 00 0.00 C ATOM 8142 N1 URI 15 24.629 10.491 5.537 1. 00 0.00 N

ATOM 8143 C6 URI 15 25.584 9.520 5.395 1.00 0.00 C ATOM 8144 C2 URI 15 23. 635 10.387 6.496 1.00 0.00 C ATOM 8145 02 URI 15 22.769 11.247 6.640 1.00 0.00 0 ATOM 8146 N3 URI 15 23.671 9.256 7.289 1.00 0.00 N ATOM 8147 C4 URI 15 24.599 8.233 7.212 1.00 0.00 C ATOM 8148 04 URI 15 24.534 7.270 7.972 1.00 0.00 0 ATOM 8149 C5 URI 15 25.598 8.422 6.185 1.00 0.00 C ATOM 8150 C2'URI 15 25.630 12.731 5.174 1.00 0.00 C ATOM 8151 02'URI 15 25.247 14.059 4.798 1.00 0.00 O ATOM 8152 C3'URI 15 26.885 12.284 4.454 1.00 0.00 C ATOM 8153 03'URI 15 27.778 13.394 4.334 1.00 0.00 0 ATOM 8154 1H5'URI 15 26.792 10.695 1.394 1.00 0.00 H ATOM 8155 2H5'URI 15 28.207 11.461 2.145 1.00 0.00 H ATOM 8156 H4'URI 15 26.223 12.856 2.494 1.00 0.00 H ATOM 8157 Hl'URI 15 23.632 12.134 4.651 1.00 0.00 H ATOM 8158 H6 URI 15 26.348 9. 630 4.625 1.00 0.00 H ATOM 8159 H3 URI 15 22.952 9.168 7.993 1.00 0.00 H ATOM 8160 H5 URI 15 26.375 7.671 6.046 1.00 0.00 H ATOM 8161 H2'URI 15 25.756 12.648 6.257 1.00 0.00 H ATOM 8162 H02'URI 15 24.447 14.274 5.283 1.00 0.00 H ATOM 8163 H3'URI 15 27.347 11.420 4.938 1.00 0.00 H ATOM 8164 P URI 16 28.902 13.657 5.455 1.00 0.00 P ATOM 8165 O1P URI 16 29.366 12.346 5.964 1.00 0.00 0 ATOM 8166 02P URI 16 29.880 14.627 4.913 1.00 0.00 O ATOM 8167 05'URI 16 28.063 14.383 6.622 1.00 0.00 0 ATOM 8168 C5'URI 16 28.698 14.780 7.841 1.00 0.00 C ATOM 8169 C4'URI 16 28.595 16.285 8.055 1.00 0.00 C ATOM 8170 04'URI 16 29.108 17.004 6.923 1.00 0. 00 0 ATOM 8171 C1'URI 16 28.080 17.831 6.363 1.00 0.00 C ATOM 8172 N1 URI 16 28.165 17.867 4.884 1.00 0.00 N ATOM 8173 C6 URI 16 27.835 16.771 4.128 1.00 0.00 C ATOM 8174 C2 URI 16 28.588 19.047 4.295 1.00 0.00 C ATOM 8175 02 URI 16 28.888 20.040 4.955 1.00 0.00 0 ATOM 8176 N3 URI 16 28. 654 19.046 2.913 1.00 0.00 N ATOM 8177 C4 URI 16 28.339 17.987 2.080 1.00 0.00 C ATOM 8178 04 URI 16 28.434 18.101 0.860 1.00 0.00 0 ATOM 8179 C5 URI 16 27.908 16.797 2.777 1.00 0.00 C ATOM 8180 C2'URI 16 26.767 17.219 6.830 1.00 0.00 C ATOM 8181 02'URI 16 25.719 18. 193 6.883 1.00 0.00 0 ATOM 8182 C3'URI 16 27.140 16.719 8.213 1.00 0.00 C ATOM 8183 03'URI 16 27.103 17.823 9.122 1.00 0.00 0 ATOM 8184 1H5'URI 16 29.747 14.494 7.810 1.00 0.00 H ATOM 8185 2H5'URI 16 28. 218 14.271 8.675 1.00 0. 00 H ATOM 8186 H4'URI 16 29.157 16.565 8.944 1.00 0.00 H ATOM 8187 H1'URI 16 28.170 18.842 6.761 1.00 0.00 H ATOM 8188 H6 URI 16 27.511 15.857 4.624 1.00 0.00 H ATOM 8189 H3 URI 16 28.962 19.900 2.471 1. 00 0.00 H ATOM 8190 H5 URI 16 27.635 15.908 2.207 1.00 0.00 H ATOM 8191 H2'URI 16 26.492 16.376 6.192 1.00 0.00 H ATOM 8192 H02'URI 16 26. 001 18.882 7.489 1.00 0.00 H ATOM 8193 H3'URI 16 26.500 15.896 8.537 1.00 0.00 H ATOM 8194 P CYT 17 25.929 17.947 10.218 1.00 0.00 P ATOM 8195 01P CYT 17 26.543 18.316 11.513 1.00 0.00 0 ATOM 8196 02P CYT 17 24.854 18.788 9.645 1.00 0. 00 0 ATOM 8197 05'CYT 17 25.383 16.435 10.334 1. 00 0.00 0 ATOM 8198 C5'CYT 17 23.981 16. 187. 10.473 1.00 0. 00 C ATOM 8199 C4'CYT 17 23.696 14.857 11.160 1.00 0.00 C ATOM 8200 04'CYT 17 24.098 13.746 10.347 1.00 0.00 0 ATOM 8201 C1'CYT 17 24.918 12.874 11.125 1.00 0.00 C ATOM 8202 N1 CYT 17 25. 8'88 12.153 10.277 1.00 0.00 N

ATOM 8203 C6 CYT 17 26.290 12.672 9.084 1.00 0.00 C ATOM 8204 C2 CYT 17 26.359 10.927 10.730 1.00 0.00 C ATOM 8205 02 CYT 17 25.983 10.479 11.812 1.00 0.00 0 ATOM 8206 N3 CYT 17 27.241 10.247 9.946 1.00 0.00 N ATOM 8207 C4 CYT 17 27.643 10.747 8.771 1.00 0.00 C ATOM 8208 N4 CYT 17 28.506 10.056 8.027 1.00 0.00 N ATOM 8209 C5 CYT 17 27.159 12.009 8.305 1.00 0.00 C ATOM 8210 C2'CYT 17 25.609 13.787 12.118 1.00 0.00 C ATOM 8211 02'CYT 17 26.075 13.069 13.267 1.00 0.00 0 ATOM 8212 C3'CYT 17 24.477 14.741 12.468 1.00 0.00 C ATOM 8213 03'CYT 17 23.633 14.109 13.439 1.00 0.00 0 ATOM 8214 1H5'CYT 17 23.526 16.180 9.489 1.00 0.00 H ATOM 8215 2H5'CYT 17 23.540 16.988 11.060 1.00 0.00 H ATOM 8216 H4'CYT 17 22.631 14.781 11.367 1.00 0.00 H ATOM 8217 H1'CYT 17 24.293 12.160 11.658 1.00 0.00 H ATOM 8218 H6 CYT 17 25.901 13.637 8.757 1.00 0.00 H ATOM 8219 1H4 CYT 17 28.851 9. 163 8.352 1.00 0.00 H ATOM 8220 2H4 CYT 17 28.816 10.424 7.139 1.00 0.00 H ATOM 8221 H5 CYT 17 27.484 12.422 7.354 1.00 0.00 H ATOM 8222 H2'CYT 17 26.423 14.332 11.631 1.00 0.00 H ATOM 8223 H02'CYT 17 26.741 12.447 12.964 1.00 0.00 H ATOM 8224 H3'CYT 17 24.843 15.710 12.805 1.00 0.00 H ATOM 8225 P GUA 18 23.046 14.940 14.689 1.00 0.00 P ATOM 8226 01P GUA 18 24.152 15.719 15.288 1.00 0.00 0 ATOM 8227 02P GUA 18 22.257 14.012 15.531 1.00 0.00 0 ATOM 8228 05'GUA 18 22.028 15.970 13.984 1.00 0.00 0 ATOM 8229 C5'GUA 18 20.847 15.499 13.326 1.00 0.00 C ATOM 8230 C4'GUA 18 20.155 16.618 12.552 1.00 0.00 C ATOM 8231 04'GUA 18 21.029 17.207 11.588 1.00 0.00 0 ATOM 8232 C1'GUA 18 20.274 17.590 10.424 1.00 0.00 C ATOM 8233 N9 GUA 18 20.818 16.955 9.206 1.00 0.00 N ATOM 8234 C4 GUA 18 21.088 15.616 9.021 1.00 0.00 C ATOM 8235 N3 GUA 18 20.883 14. 632 9.925 1.00 0.00 N ATOM 8236 C2 GUA 18 21.244 13.433 9.458 1.00 0.00 C ATOM 8237 N2 GUA 18 21.111 12.351 10.226 1.00 0.00 N ATOM 8238 N1 GUA 18 21.766 13.228 8.196 1.00 0.00 N ATOM 8239 C6 GUA 18 21.985 14.222 7.250 1.00 0.00 C ATOM 8240 06 GUA 18 22.457 13.936 6.152 1.00 0.00 0 ATOM 8241 C5 GUA 18 21.603 15.499 7.739 1.00 0.00 C ATOM 8242 N7 GUA 18 21.660 16.748 7.115 1.00 0.00 N ATOM 8243 C8 GUA 18 21.189 17.523 8.032 1.00 0.00 C ATOM 8244 C2'GUA 18 18. 827 17.162 10.679 1.00 0.00 C ATOM 8245 02'GUA 18 18.034 18.258 11.150 1.00 0.00 0 ATOM 8246 C3'GUA 18 18.985 16.090 11.743 1.00 0.00 C ATOM 8247 03'GUA 18 17.819 16.093 12.575 1.00 0.00 0 ATOM 8248 1H5'GUA 18 20.157 15.103 14.072 1.00 0.00 H ATOM 8249 2H5'GUA 18 21.118 14.703 12.634 1.00 0.00 H ATOM 8250 H4'GUA 18 19.809 17.386 13.243 1.00 0.00 H ATOM 8251 H1'GUA 18 20.313 18.674 10.313 1.00 0.00 H ATOM 8252 1H2 GUA 18 21.383 11.445 9.874 1.00 0.00 H ATOM 8253 2H2 GUA 18 20.736 12.439 11.160 1.00 0.00 H ATOM 8254 H1 GUA 18 22.016 12.290 7.916 1.00 0.00 H ATOM 8255 H8 GUA 18 21.092 18.596 7.869 1.00 0.00 H ATOM 8256 H2'GUA 18 18.396 16.732 9.770 1.00 0.00 H ATOM 8257 H02'GUA 18 17.182 17.902 11.412 1.00 0.00 H ATOM 8258 H3'GUA 18 19.192 15.111 11.310 1.00 0.00 H ATOM 8259 P GUA 19 16.503 15.267 12.151 1.00 0.00 P ATOM 8260 O1P GUA 19 16.917 13.893 11.784 1.00 0.00 O ATOM 8261 02P GUA 19 15.471 15. 474 13. 191 1.00 0.00 0 ATOM 8262 05'GUA 19 16.027 16.028 10.812 1.00 0.00 0

ATOM 8263 C5'GUA 19 15.556 15.291 9.679 1.00 0.00 C ATOM 8264 C4'GUA 19 16.211 15.770 8.386 1.00 0.00 C ATOM 8265 04'GUA 19 17.642 15.657 8.450 1.00 0.00 0 ATOM 8266 C1'GUA 19 18.119 14.946 7.296 1.00 0. 00 C ATOM 8267 N9 GUA 19 18.440 13.545 7.629 1.00 0.00 N ATOM 8268 C4 GUA 19 19.083 12.633 6.821 1.00 0.00 C ATOM 8269 N3 GUA 19 19.544 12.866 5.571 1.00 0.00 N ATOM 8270 C2 GUA 19 20.123 11.786 5.037 1.00 0.00 C ATOM 8271 N2 GUA 19 20.630 11.841 3.806 1.00 0.00 N ATOM 8272 N1 GUA 19 20.236 10.576 5.691 1.00 0.00 N ATOM 8273 C6 GUA 19 19.771 10.313 6.973 1.00 0.00 C ATOM 8274 06 GUA 19 19.922 9.199 7.467 1.00 0.00 0 ATOM 8275 C5 GUA 19 19.154 11.454 7.548 1.00 0.00 C ATOM 8276 N7 GUA 19 18.563 11.613 8.804 1.00 0.00 N ATOM 8277 C8 GUA 19 18.182 12.845 8.761 1.00 0.00 C ATOM 8278 C2'GUA 19 16.987 15.022 6.287 1.00 0.00 C ATOM 8279 02'GUA 19 16.997 16.268 5.578 1.00 0.00 0 ATOM 8280 C3'GUA 19 15.787 14.907 7.204 1.00 0.00 C ATOM 8281 03'GUA 19 14.662 15.518 6.565 1.00 0.00 0 ATOM 8282 1H5'GUA 19 14.476 15.414 9.598 1.00 0.00 H ATOM 8283 2H5'GUA 19 15.783 14.234 9.822 1.00 0.00 H ATOM 8284 H4'GUA 19 15.938 16.808 8.200 1.00 0.00 H ATOM 8285 H1'GUA 19 19.003 15.443 6.896 1.00 0.00 H ATOM 8286 1H2 GUA 19 20.576 12.699 3.275 1.00 0.00 H ATOM 8287 2H2 GUA 19 21.069 11.025 3.403 1.00 0.00 H ATOM 8288 H1 GUA 19 20.690 9.807 5.220 1.00 0.00 H ATOM 8289 H8 GUA 19 17.671 13. 306 9.605 1.00 0.00 H ATOM 8290 H2'GUA 19 17.029 14.173 5.600 1.00 0.00 H ATOM 8291 H02'GUA 19 16.089 16.466 5.337 1.00 0.00 H ATOM 8292 H3'GUA 19 15.596 13.874 7.497 1.00 0.00 H ATOM 8293 P ADE 20 13.632 14.629 5.703 1.00 0.00 P ATOM 8294 01P ADE 20 12.634 15.537 5.095 1.00 0.00 0 ATOM 8295 02P ADE 20 13. 183 13.497 6.544 1.00 0.00 0 ATOM 8296 05'ADE 20 14.568 14.044 4.529 1.00 0.00 0 ATOM 8297 C5'ADE 20 15.008 14.886 3.459 1.00 0.00 C ATOM 8298 C4'ADE 20 15.965 14.154 2.521 1.00 0.00 C ATOM 8299 04'ADE 20 17.119 13.660 3.211 1.00 0.00 0 ATOM 8300 C1'ADE 20 17.473 12.364 2.684 1.00 0.00 C ATOM 8301 N9 ADE 20 17.318 11.306 3.704 1.00 0.00 N ATOM 8302 C4 ADE 20 17.836 10.029 3.652 1.00 0.00 C ATOM 8303 N3 ADE 20 18.574 9.504 2.653 1.00 0.00 N ATOM 8304 C2 ADE 20 18.917 8.247 2.914 1.00 0.00 C ATOM 8305 N1 ADE 20 18.609 7.535 3.999 1.00 0.00 N ATOM 8306 C6 ADE 20 17.873 8.079 4.983 1.00 0.00 C ATOM 8307 N6 ADE 20 17.589 7.353 6.064 1.00 0.00 N ATOM 8308 C5 ADE 20 17.452 9.404 4.816 1.00 0.00 C ATOM 8309 N7 ADE 20 16.692 10.264 5.614 1.00 0.00 N ATOM 8310 C8 ADE 20 16.667 11.335 4.893 1.00 0.00 C ATOM 8311 C2'ADE 20 16.538 12.123 1.503 1.00 0.00 C ATOM 8312 02'ADE 20 17.097 12.621 0.281 1.00 0.00 0 ATOM 8313 C3'ADE 20 15.320 12.916 1.926 1.00 0.00 C ATOM 8314 03'ADE 20 14.583 13.290 0.760 1.00 0.00 O ATOM 8315 1H5'ADE 20 15.516 15.756 3.875 1.00 0.00 H ATOM 8316 2H5'ADE 20 14.140 15.220 2.891 1.00 0.00 H ATOM 8317 H4'ADE 20 16.281 14.823 1.722 1.00 0.00 H ATOM 8318 H1'ADE 20 18.505 12.384 2.332 1.00 0.00 H ATOM 8319 H2 ADE 20 19.517 7.740 2.157 1.00 0.00 H ATOM 8320 1H6 ADE 20 17.043 7.755 6.813 1.00 0.00 H ATOM 8321 2H6 ADE 20 17.922 6.402 6.136 1. 00 0. 00 H ATOM 8322 H8 ADE 20 16.137 12.228 5.225 1.00 O. 00 H

ATOM 8323 H2'ADE 20 16.295 11.062 1.422 1.00 0.00 H ATOM 8324 H02'ADE 20 17.320 13.544 0.424 1.00 0.00 H ATOM 8325 H3'ADE 20 14.714 12.377 2.656 1.00 0.00 H ATOM 8326 P GUA 21 13.504 12.279 0.122 1.00 0.00 P ATOM 8327 01P GUA 21 12.868 12.949-1. 035 1.00 0.00 0 ATOM 8328 02P GUA 21 12.664 11.744 1.217 1.00 0.00 O ATOM 8329 05'GUA 21 14.430 11.083-0. 433 1.00 0.00 0 ATOM 8330 C5'GUA 21 15.212 11.262-1. 617 1.00 0.00 C ATOM 8331 C4'GUA 21 15.941 9.980-2. 012 1.00 0.00 C ATOM 8332 04'GUA 21 16.882 9.568-1. 016 1.00 0.00 0 ATOM 8333 C1'GUA 21 16.887 8.128-0. 931 1.00 0.00 C ATOM 8334 N9 GUA 21 16.463 7.670 0.408 1.00 0.00 N ATOM 8335 C4 GUA 21 16.744 6.452 0.988 1.00 0.00 C ATOM 8336 N3 GUA 21 17.430 5.438 0.412 1.00 0.00 N ATOM 8337 C2 GUA 21 17.543 4.381 1.222 1.00 0.00 C ATOM 8338 N2 GUA 21 18.178 3.285 0.806 1.00 0.00 N ATOM 8339 N1 GUA 21 17.021 4.335 2.499 1.00 0.00 N ATOM 8340 C6 GUA 21 16.315 5.362 3.112 1.00 0.00 C ATOM 8341 06 GUA 21 15.902 5.225 4.261 1.00 0.00 O ATOM 8342 C5 GUA 21 16.187 6.489 2.257 1.00 0.00 C ATOM 8343 N7 GUA 21 15.555 7.715 2.483 1.00 0.00 N ATOM 8344 C8 GUA 21 15.764 8.327 1.366 1.00 0.00 C ATOM 8345 C2'GUA 21 15.929 7.637-2. 015 1.00 0.00 C ATOM 8346 02'GUA 21 16.615 7.385-3. 248 1.00 0.00 O ATOM 8347 C3'GUA 21 14.982 8.813-2. 134 1.00 0.00 C ATOM 8348 03'GUA 21 14.411 8.823-3. 446 1.00 0.00 0 ATOM 8349 1H5'GUA 21 15.946 12.049-1. 445 1.00 0.00 H ATOM 8350 2H5'GUA 21 14.555 11.561-2. 433 1.00 0.00 H ATOM 8351 H4'GUA 21 16.460 10.130-2. 958 1.00 0.00 H ATOM 8352 Hl'GUA 21 17.891 7.756-1. 141 1.00 0.00 H ATOM 8353 1H2 GUA 21 18.576 3.255-0. 122 1.00 0.00 H ATOM 8354 2H2 GUA 21 18.260 2.485 1.417 1.00 0.00 H ATOM 8355 Hl GUA 21 17.152 3.500 3.050 1.00 0.00 H ATOM 8356 H8 GUA 21 15.383 9.334 1.197 1.00 0.00 H ATOM 8357 H2'GUA 21 15.394 6.749-1. 673 1.00 0.00 H ATOM 8358 H02'GUA 21 17.070 8.194-3. 491 1.00 0.00 H ATOM 8359 H3'GUA 21 14.228 8.814-1. 345 1.00 0.00 H ATOM 8360 P ADE 22 13.000 8.100-3. 732 1.00 0.00 P ATOM 8361 O1P ADE 22 12.513 8.543-5. 057 1.00 0.00 0 ATOM 8362 02P ADE 22 12.140 8. 268-2.538 1.00 0.00 0 ATOM 8363 05'ADE 22 13.416 6.548-3. 838 1.00 0.00 0 ATOM 8364 C5'ADE 22 14.188 6.079-4. 948 1.00 0. 00 C ATOM 8365 C4'ADE 22 14.831 4.725-4. 659 1.00 0.00 C ATOM 8366 04'ADE 22 15. 647 4.769-3. 483 1.00 0.00 0 ATOM 8367 C1'ADE 22 15.470 3.554-2. 730 1.00 0.00 C ATOM 8368 N9 ADE 22 14.828 3.813-1. 427 1.00 0.00 N ATOM 8369 C4 ADE 22 14.933 3.039-0. 296 1.00 0.00 C ATOM 8370 N3 ADE 22 15.650 1.905-0. 170 1.00 0.00 N ATOM 8371 C2 ADE 22 15.541 1.398 1.052 1.00 0.00 C ATOM 8372 N1 ADE 22 14.834 1.893 2.070 1.00 0. 00 N ATOM 8373 C6 ADE 22 14.127 3.027 1.920 1.00 0.00 C ATOM 8374 N6 ADE 22 13.427 3.504 2.948 1.00 0.00 N ATOM 8375 C5 ADE 22 14.168 3.650 0.669 1.00 0.00 C ATOM 8376 N7 ADE 22 13.570 4.811 0.168 1.00 0. 00 N ATOM 8377 C8 ADE 22 14.007 4.824-1. 046 1.00 0.00 C ATOM 8378 C2'ADE 22 14.602 2.646-3. 593 1.00 0.00 C ATOM 8379 02'ADE 22 15.401 1.833-4. 461 1.00 0.00 O ATOM 8380 C3'ADE 22 13.788 3.662-4. 367 1.00 0.00 C ATOM 8381 03'ADE 22 13.369 3.071-5. 601 1.00 0.00 0 ATOM 8382 1H5'ADE 22 14. 972 6.804-5. 167 1.00 0.00 H

ATOM 8383 2H5'ADE 22 13.538 5.986-5. 818 1. 00 0.00 H ATOM 8384 H4'ADE 22 15.440 4.418-5. 508 1.00 0.00 H ATOM 8385 H1'ADE 22 16.440 3.083-2. 570 1.00 0.00 H ATOM 8386 H2 ADE 22 16.088 0.475 1.244 1.00 0.00 H ATOM 8387 1H6 ADE 22 12.892 4.355 2.842 1.00 0.00 H ATOM 8388 2H6 ADE 22 13.431 3.016 3.832 1.00 0.00 H ATOM 8389 H8 ADE 22 13.725 5.616-1. 739 1.00 0.00 H ATOM 8390 H2'ADE 22 13.951 2.032-2. 964 1.00 0.00 H ATOM 8391 H02'ADE 22 15.812 1.155-3. 918 1.00 0.00 H ATOM 8392 H3'ADE 22 12.954 4.051-3. 780 1.00 0.00 H ATOM 8393 P CYT 23 12.096 2.083-5. 645 1.00 0. 00 P ATOM 8394 01P CYT 23 11.877 1.672-7. 050 1.00 0.00 O ATOM 8395 02P CYT 23 10.995 2.711-4. 881 1.00 0.00 0 ATOM 8396 05'CYT 23 12.613 0.801-4. 818 1.00 0.00 O ATOM 8397 C5'CYT 23 13.606-0. 070-5.367 1.00 0.00 C ATOM 8398 C4'CYT 23 13.964-1. 197-4.402 1.00 0.00 C ATOM 8399 04'CYT 23 14.453-0. 696-3.158 1.00 0.00 O ATOM 8400 C1'CYT 23 14.048-1. 580-2.094 1.00 0.00 C ATOM 8401 N1 CYT 23 13.303-0. 849-1.043 1.00 0.00 N ATOM 8402 C6 CYT 23 12.405 0.129-1. 363 1.00 0.00 C ATOM 8403 C2 CYT 23 13.557-1. 194 0.279 1.00 0.00 C ATOM 8404 02 CYT 23 14.368-2. 079 0.544 1.00 0.00 O ATOM 8405 N3 CYT 23 12.886-0. 530 1.259 1.00 0.00 N ATOM 8406 C4 CYT 23 12.003 0.430 0.961 1.00 0.00 C ATOM 8407 N4 CYT 23 11.365 1.059 1.948 1.00 0.00 N ATOM 8408 C5 CYT 23 11.737 0.790-0. 398 1.00 0.00 C ATOM 8409 C2'CYT 23 13.181-2. 669-2.734 1.00 0.00 C ATOM 8410 02'CYT 23 13.938-3. 861-2.980 1.00 0.00 0 ATOM 8411 C3'CYT 23 12.742-2. 012-4.029 1.00 0.00 C ATOM 8412 03'CYT 23 12.559-3. 027-5.018 1.00 0.00 O ATOM 8413 1H5'CYT 23 14.504 0.508-5. 587 1.00 0.00 H ATOM 8414 2H5'CYT 23 13.227-0. 502-6.294 1.00 0.00 H ATOM 8415 H4'CYT 23 14.715-1. 844-4. 852 1.00 0.00 H ATOM 8416 H1'CYT 23 14.931-2. 041-1.655 1.00 0.00 H ATOM 8417 H6 CYT 23 12.229 0.379-2. 409 1.00 0.00 H ATOM 8418 1H4 CYT 23 10.696 1.785 1.736 1.00 0.00 H ATOM 8419 2H4 CYT 23 11.551 0. 809 2.909 1.00 0.00 H ATOM 8420 H5 CYT 23 11.015 1.568-0. 643 1.00 0.00 H ATOM 8421 H2'CYT 23 12.314-2. 879-2.103 1.00 0.00 H ATOM 8422 H02'CYT 23 13.414-4. 416-3.563 1.00 0.00 H ATOM 8423 H3'CYT 23 11.856-1. 390-3.893 1.00 0.00 H ATOM 8424 P GUA 24 11.349-2. 937-6.076 1.00 0.00 P ATOM 8425 01P GUA 24 10.439-1. 848-5.654 1.00 0.00 O ATOM 8426 02P GUA 24 11.923-2. 932-7.440 1.00 0.00 O ATOM 8427 05'GUA 24 10.593-4. 339-5. 849 1.00 0.00 O ATOM 8428 C5'GUA 24 11.194-5. 568-6.269 1.00 0.00 C ATOM 8429 C4'GUA 24 10.755-6. 734-5.389 1.00 0.00 C ATOM 8430 04'GUA 24 11. 213-6. 580-4.036 1.00 0.00 O ATOM 8431 C1'GUA 24 10.125-6. 835-3.130 1.00 0.00 C ATOM 8432 N9 GUA 24 9.628-5. 585-2. 528 1.00 0.00 N ATOM 8433 C4 GUA 24 8.686-5. 481-1.534 1.00 0.00 C ATOM 8434 N3 GUA 24 8.060-6. 515-0.930 1.00 0.00 N ATOM 8435 C2 GUA 24 7. 196-6. 107 0.000 1.00 0.00 C ATOM 8436 N2 GUA 24 6.493-7. 001 0.696 1.00 0.00 N ATOM 8437 N1 GUA 24 6.972-4. 781 0.304 1.00 0.00 N ATOM 8438 C6 GUA 24 7.601-3. 702-0.302 1.00 0.00 C ATOM 8439 06 GUA 24 7.323-2. 555 0.039 1.00 0.00 O ATOM 8440 C5 GUA 24 8.524-4. 127-1.291 1. 00 0.00 C ATOM 8441 N7 GUA 24 9.358-3. 374-2.124 1.00 0.00 N ATOM 8442 C8 GUA 24 9.956-4. 297-2.799 1.00 0.00 C

ATOM 8443 C2'GUA 24 9.047-7. 509-3.968 1.00 0.00 C ATOM 8444 02'GUA 24 9.270-8. 920-4.082 1.00 0.00 0 ATOM 8445 C3'GUA 24 9.238-6. 802-5.293 1.00 0.00 C ATOM 8446 03'GUA 24 8.749-7. 640-6.345 1.00 0.00 0 ATOM 8447 1H5'GUA 24 12.279-5. 473-6.219 1. 00 0. 00 H ATOM 8448 2H5'GUA 24 10.902-5. 771-7.299 1.00 0.00 H ATOM 8449 H4'GUA 24 11.139-7. 668-5.797 1.00 0.00 H ATOM 8450 Hl'GUA 24 10.451-7. 513-2.340 1.00 0.00 H ATOM 8451 1H2 GUA 24 6.616-7. 987 0.519 1.00 0.00 H ATOM 8452 2H2 GUA 24 5.839-6. 692 1.400 1.00 0.00 H ATOM 8453 H1 GUA 24 6.305-4. 556 1.022 1.00 0.00 H ATOM 8454 H8 GUA 24 10.708-4. 050-3.549 1.00 0.00 H ATOM 8455 H2'GUA 24 8.056-7. 296-3.558 1.00 0.00 H ATOM 8456 H02'GUA 24 10.177-9. 042-4.371 1.00 0.00 H ATOM 8457 H3'GUA 24 8.781-5. 811-5.296 1.00 0.00 H ATOM 8458 P ADE 25 7.307-7. 363-7.006 1.00 0.00 P ATOM 8459 01P ADE 25 7.149-5. 902-7.182 1.00 0.00 0 ATOM 8460 02P ADE 25 7.149-8. 268-8.167 1.00 0.00 0 ATOM 8461 05'ADE 25 6.296-7. 844-5.850 1.00 0.00 O ATOM 8462 C5'ADE 25 6.234-9. 223-5.477 1.00 0.00 C ATOM 8463 C4'ADE 25 5.523-9. 419-4.142 1.00 0.00 C ATOM 8464 04'ADE 25 6.131-8. 654-3.096 1.00 0.00 0 ATOM 8465 C1'ADE 25 5.104-8. 139-2.225 1.00 0.00 C ATOM 8466 N9 ADE 25 5.053-6. 663-2.271 1.00 0.00 N ATOM 8467 C4 ADE 25 4.280-5. 845-1.479 1.00 0.00 C ATOM 8468 N3 ADE 25 3.420-6. 241-0.520 1.00 0.00 N ATOM 8469 C2 ADE 25 2.830-5. 202 0.059 1.00 0.00 C ATOM 8470 N1 ADE 25 3.015-3. 911-0. 221 1.00 0.00 N ATOM 8471 C6 ADE 25 3.878-3. 540-1.182 1.00 0.00 C ATOM 8472 N6 ADE 25 4.048-2. 244-1.442 1.00 0.00 N ATOM 8473 C5 ADE 25 4.559-4. 554-1.862 1.00 0.00 C ATOM 8474 N7 ADE 25 5.503-4. 534-2.893 1.00 0.00 N ATOM 8475 C8 ADE 25 5.729-5. 794-3.063 1.00 0.00 C ATOM 8476 C2'ADE 25 3.792-8. 747-2.716 1.00 0.00 C ATOM 8477 02'ADE 25 3.519-9. 997-2.072 1.00 0.00 0 ATOM 8478 C3'ADE 25 4. 088-8. 928-4.190 1.00 0. 00 C ATOM 8479 03'ADE 25 3.265-9. 976-4.710 1.00 0.00 O ATOM 8480 lH5'ADE 25 7.249-9. 615-5.399 1.00 0.00 H ATOM 8481 2H5'ADE 25 5.699-9. 776-6.249 1.00 0.00 H ATOM 8482 H4'ADE 25 5.539-10. 473-3.870 1.00 0.00 H ATOM 8483 Hl'ADE 25 5.296-8. 466-1.203 1.00 0.00 H ATOM 8484 H2 ADE 25 2.113-5. 428 0.849 1. 00 0.00 H ATOM 8485 1H6 ADE 25 4.695-1. 954-2.162 1.00 0.00 H ATOM 8486 2H6 ADE 25 3.531-1. 551-0.919 1.00 0.00 H ATOM 8487 H8 ADE 25 6.431-6. 145-3.818 1.00 0.00 H ATOM 8488 H2'ADE 25 2.970-8. 040-2.575 1.00 0.00 H ATOM 8489 H02'ADE 25 4.285-10. 560-2.206 1.00 0.00 H ATOM 8490 H3'ADE 25 3.982-7. 993-4.742 1.00 0.00 H ATOM 8491 P CYT 26 1.768-9. 667-5.215 1.00 0.00 P ATOM 8492 01P CYT 26 1.773-8. 366-5.921 1.00 0.00 O ATOM 8493 02P CYT 26 1.249-10. 875-5.896 1.00 0.00 0 ATOM 8494 05'CYT 26 0.971-9. 484-3.831 1.00 0.00 O ATOM 8495 C5'CYT 26 0.771-10. 597-2.955 1.00 0.00 C ATOM 8496 C4'CYT 26-0.029-10. 199-1.721 1.00 0.00 C ATOM 8497 04'CYT 26 0.673-9. 247-0.909 1.00 0.00 O ATOM 8498 C1'CYT 26-0.242-8. 217-0.483 1.00 0.00 C ATOM 8499 N1 CYT 26 0.041-6. 934-1.155 1.00 0.00 N ATOM 8500 C6 CYT 26 0.616-6. 904-2.391 1.00 0.00 C ATOM 8501 C2 CYT 26-0. 334-5.767-0. 501 1.00 0. 00 C ATOM 8502 02 CYT 26-0. 849-5.820 0.615 1.00 0.00 0

ATOM 8503 N3 CYT 26-0. 117-4. 579-1.127 1.00 0.00 N ATOM 8504 C4 CYT 26 0.442-4. 537-2.342 1.00 0.00 C ATOM 8505 N4 CYT 26 0.634-3. 358-2.930 1.00 0.00 N ATOM 8506 C5 CYT 26 0.829-5. 739-3.016 1.00 0.00 C ATOM 8507 C2'CYT 26-1.630-8. 720-0.853 1.00 0.00 C ATOM 8508 02'CYT 26-2.182-9. 555 0.171 1.00 0.00 0 ATOM 8509 C3'CYT 26-1.320-9. 501-2.112 1.00 0.00 C ATOM 8510 03'CYT 26-2.332-10. 493-2.312 1.00 0.00 0 ATOM 8511 1H5'CYT 26 1. 741-10. 984-2. 641 1.00 0.00 H ATOM 8512 2H5'CYT 26 0.232-11. 378-3.491 1.00 0.00 H ATOM 8513 H4'CYT 26-0.256-11. 083-1.127 1.00 0.00 H ATOM 8514 Hl'CYT 26-0.175-8. 089 0.595 1.00 0.00 H ATOM 8515 H6 CYT 26 0.920-7. 835-2.873 1.00 0.00 H ATOM 8516 1H4 CYT 26 1.052-3. 313-3.848 1.00 0.00 H ATOM 8517 2H4 CYT 26 0.360-2. 508-2.458 1.00 0.00 H ATOM 8518 H5 CYT 26 1.254-5. 715-4.013 1.00 0.00 H ATOM 8519 H2'CYT 26-2.289-7. 876-1.077 1.00 0.00 H ATOM 8520 H02'CYT 26-2.327-9. 002 0.943 1.00 0.00 H ATOM 8521 H3'CYT 26-1.186-8. 845-2.977 1.00 0.00 H ATOM 8522 P CYT 27-3.008-10. 699-3.759 1.00 0.00 P ATOM 8523 01P CYT 27-3.601-12. 054-3.805 1.00 0.00 0 ATOM 8524 02P CYT 27-2.033-10. 283-4.793 1.00 0.00 0 ATOM 8525 05'CYT 27-4.205-9. 623-3.736 1.00 0.00 O ATOM 8526 C5'CYT 27-5.200-9. 671-2.708 1.00 0.00 C ATOM 8527 C4'CYT 27-5.516-8. 280-2.167 1.00 0.00 C ATOM 8528 04'CYT 27-4. 332-7.597-1. 743 1.00 0.00 0 ATOM 8529 C1'CYT 27-4.448-6. 196-2.063 1.00 0.00 C ATOM 8530 N1 CYT 27-3.398-5. 761-3.014 1.00 0.00 N ATOM 8531 C6 CYT 27-2.709-6. 663-3.776 1.00 0.00 C ATOM 8532 C2 CYT 27-3. 156-4.398-3. 112 1.00 0.00 C ATOM 8533 02 CYT 27-3.791-3. 607-2.420 1.00 0.00 0 ATOM 8534 N3 CYT 27-2.211-3. 970-3.991 1.00 0.00 N ATOM 8535 C4 CYT 27-1.529-4. 839-4.746 1.00 0.00 C ATOM 8536 N4 CYT 27-0.602-4. 382-5.586 1.00 0.00 N ATOM 8537 C5 CYT 27-1.773-6. 246-4.654 1.00 0.00 C ATOM 8538 C2'CYT 27-5.840-6. 011-2.667 1.00 0.00 C ATOM 8539 02'CYT 27-6.803-5. 659-1.667 1.00 0.00 0 ATOM 8540 C3'CYT 27-6.106-7. 387-3.242 1.00 0.00 C ATOM 8541 03'CYT 27-7.520-7. 601-3.293 1.00 0.00 0 ATOM 8542 1H5'CYT 27-4.839-10. 296-1.891 1.00 0.00 H ATOM 8543 2H5'CYT 27-6. 111-10. 110-3. 115 1.00 0.00 H ATOM 8544 H4'CYT 27-6.208-8. 357-1.331 1.00 0.00 H ATOM 8545 Hl'CYT 27-4.372-5. 610-1.147 1.00 0.00 H ATOM 8546 H6 CYT 27-2.906-7. 728-3.661 1.00 0.00 H ATOM 8547 1H4 CYT 27-0. 074-5. 028-6. 156 1.00 0.00 H ATOM 8548 2H4 CYT 27-0. 423-3. 390-5. 647 1.00 0.00 H ATOM 8549 H5 CYT 27-1. 227-6. 954-5. 281 1.00 0.00 H ATOM 8550 H2'CYT 27-5.811-5. 264-3. 465 1.00 0.00 H ATOM 8551 H02'CYT 27-6.594-4. 771-1.369 1.00 0.00 H ATOM 8552 H3'CYT 27-5.620-7. 529-4.209 1.00 0.00 H ATOM 8553 P GUA 28-8.333-7. 371-4.665 1.00 0.00 P ATOM 8554 01P GUA 28-7. 595-8. 042-5. 759 1.00 0.00 0 ATOM 8555 02P GUA 28-9.754-7. 705-4.422 1.00 0.00 0 ATOM 8556 05'GUA 28-8.215-5. 778-4.880 1.00 0.00 0 ATOM 8557 C5'GUA 28-9.195-4. 894-4.329 1. 00 0.00 C ATOM 8558 C4'GUA 28-8.978-3. 454-4.788 1.00 0.00 C ATOM 8559 04'GUA 28-7.722-2. 939-4.351 1.00 0.00 0 ATOM 8560 C1'GUA 28-7.231-1. 999-5.327 1.00 0.00 C ATOM 8561 N9 GUA 28-5.872-2. 356-5.782 1.00 0.00 N ATOM 8562 C4 GUA 28-4.940-1. 499-6.322 1.00 0.00 C

ATOM 8563 N3 GUA 28-5.114-0. 177-6.540 1.00 0.00 N ATOM 8564 C2 GUA 28-4.032 0.393-7. 076 1.00 0.00 C ATOM 8565 N2 GUA 28-4.040 1.694-7. 361 1.00 0.00 N ATOM 8566 N1 GUA 28-2.871-0. 292-7.371 1.00 0.00 N ATOM 8567 C6 GUA 28-2. 667-1.649-7. 157 1.00 0.00 C ATOM 8568 06 GUA 28-1.592-2. 164-7.454 1.00 0. 00 0 ATOM 8569 C5 GUA 28-3.815-2. 265-6.587 1.00 0.00 C ATOM 8570 N7 GUA 28-4.030-3. 597-6.221 1.00 0.00 N ATOM 8571 C8 GUA 28-5.238-3. 555-5.768 1.00 0.00 C ATOM 8572 C2'GUA 28-8. 225-2.020-6. 492 1.00 0.00 C ATOM 8573 02'GUA 28-9.153-0. 932-6.409 1.00 0.00 0 ATOM 8574 C3'GUA 28-8.915-3. 358-6.299 1.00 0.00 C ATOM 8575 03'GUA 28-10. 249-3.269-6. 809 1.00 0.00 0 ATOM 8576 1H5'GUA 28-9.140-4. 932-3. 242 1.00 0.00 H ATOM 8577 2H5'GUA 28-10.186-5. 221-4.647 1.00 0.00 H ATOM 8578 H4'GUA 28-9.780-2. 821-4.411 1.00 0.00 H ATOM 8579 Hl'GUA 28-7. 214-1.001-4. 888 1.00 0.00 H ATOM 8580 1H2 GUA 28-4.863 2.248-7. 172 1.00 0.00 H ATOM 8581 2H2 GUA 28-3.223 2.127-7. 766 1.00 0.00 H ATOM 8582 Hl GUA 28-2.095 0.215-7. 773 1.00 0.00 H ATOM 8583 H8 GUA 28-5.732-4. 450-5.392 1.00 0.00 H ATOM 8584 H2'GUA 28-7.689-2. 006-7.444 1.00 0.00 H ATOM 8585 H02'GUA 28-9.615-1. 014-5.572 1.00 0.00 H ATOM 8586 H3'GUA 28-8.348-4. 178-6.741 1.00 0.00 H ATOM 8587 P CYT 29-10.555-3. 590-8.357 1.00 0.00 P ATOM 8588 01P CYT 29-12.022-3. 693-8.527 1.00 0.00 0 ATOM 8589 02P CYT 29-9. 684-4.710-8. 779 1.00 0.00 0 ATOM 8590 05'CYT 29-10.051-2. 253-9.103 1.00 0.00 0 ATOM 8591 C5'CYT 29-10.942-1. 153-9.313 1.00 0.00 C ATOM 8592 C4'CYT 29-10.328-0. 096-10.227 1.00 0.00 C ATOM 8593 04'CYT 29-9.143 0.473-9. 655 1.00 0.00 0 ATOM 8594 Cl'CYT 29-8. 136 0.623-10. 673 1.00 0.00 C ATOM 8595 N1 CYT 29-6.981-0. 271-10.423 1.00 0.00 N ATOM 8596 C6 CYT 29-7. 158-1. 524-9.906 1.00 0.00 C ATOM 8597 C2 CYT 29-5.713 0.215-10. 720 1.00 0.00 C ATOM 8598 02 CYT 29-5.575 1.344-11. 189 1.00 0.00 0 ATOM 8599 N3 CYT 29-4.642-0. 590-10.483 1.00 0.00 N ATOM 8600 C4 CYT 29-4.802-1. 819-9.977 1.00 0.00 C ATOM 8601 N4 CYT 29-3.730-2. 579-9.758 1.00 0.00 N ATOM 8602 C5 CYT 29-6.103-2. 325-9.670 1.00 0.00 C ATOM 8603 C2'CYT 29-8.821 0.289-11. 996 1.00 0.00 C ATOM 8604 02'CYT 29-9.407 1.453-12. 591 1.00 0.00 0 ATOM 8605 C3'CYT 29-9.877-0. 701-11.547 1.00 0.00 C ATOM 8606 03'CYT 29-10.972-0. 660-12.468 1.00 0.00 0 ATOM 8607 1H5'CYT 29-11.179-0. 697-8.351 1.00 0.00 H ATOM 8608 2H5'CYT 29-11.862-1. 523-9.767 1.00 0.00 H ATOM 8609 H4'CYT 29-11. 053 0.695-10. 415 1.00 0.00 H ATOM 8610 Hl'CYT 29-7.796 1.659-10. 695 1.00 0.00 H ATOM 8611 H6 CYT 29-8.165-1. 878-9.682 1. 00 0.00 H ATOM 8612 1H4 CYT 29-3.838-3. 508-9.377 1.00 0.00 H ATOM 8613 2H4 CYT 29-2. 807-2. 225-9.971 1.00 0.00 H ATOM 8614 H5 CYT 29-6.236-3. 326-9.258 1.00 0.00 H ATOM 8615 H2'CYT 29-8.115-0. 189-12.678 1.00 0.00 H ATOM 8616 H02'CYT 29-10.006 1.833-11. 945 1.00 0. 00 H ATOM 8617 H3'CYT 29-9.469-1. 705-11.422 1.00 0. 00 H ATOM 8618 P CYT 30-11.055-1. 706-13.692 1.00 0. 00 P ATOM 8619 01P CYT 30-12.407-1. 615-14.289 1.00 0.00 O ATOM 8620 02P CYT 30-10.543-3. 012-13.222 1.00 0. 00 0 ATOM 8621 05'CYT 30-9.996-1. 102-14.746 1.00 0.00 0 ATOM 8622 C5'CYT 30-10.292 0.093-15. 477 1.00 0.00 C

ATOM 8623 C4'CYT 30-9.023 0.748-16. 017 1.00 0.00 C ATOM 8624 04'CYT 30-8.091 1.026-14. 967 1.00 0.00 0 ATOM 8625 C1'CYT 30-6.759 0.733-15. 419 1.00 0.00 C ATOM 8626 N1 CYT 30-6.166-0. 391-14.658 1.00 0.00 N ATOM 8627 C6 CYT 30-6.895-1. 507-14.358 1.00 0.00 C ATOM 8628 C2 CYT 30-4.839-0. 268-14.267 1.00 0.00 C ATOM 8629 02 CYT 30-4.203 0. 747-14. 543 1.00 0.00 0 ATOM 8630 N3 CYT 30-4. 273-1. 293-13.574 1.00 0.00 N ATOM 8631 C4 CYT 30-4.975-2. 393-13.276 1.00 0.00 C ATOM 8632 N4 CYT 30-4.386-3. 380-12.602 1.00 0.00 N ATOM 8633 C5 CYT 30-6.342-2. 525-13.673 1. 00 0.00 C ATOM 8634 C2'CYT 30-6.884 0.397-16. 903 1.00 0.00 C ATOM 8635 02'CYT 30-6.756 1.570-17. 716 1.00 0.00 0 ATOM 8636 C3'CYT 30-8.285-0. 176-16.972 1.00 0.00 C ATOM 8637 03'CYT 30-8.822-0. 115-18.298 1.00 0.00 0 ATOM 8638 1H5'CYT 30-10.802 0.797-14. 819 1.00 0.00 H ATOM 8639 2H5'CYT 30-10.949-0. 154-16. 311 1.00 0.00 H ATOM 8640 H4'CYT 30-9. 278 1.676-16. 528 1.00 0.00 H ATOM 8641 H1'CYT 30-6.136 1.621-15. 301 1.00 0.00 H ATOM 8642 H6 CYT 30-7.937-1. 572-14.671 1.00 0.00 H ATOM 8643 1H4 CYT 30-4.905-4. 216-12.373 1.00 0.00 H ATOM 8644 2H4 CYT 30-3. 418-3. 295-12.325 1.00 0.00 H ATOM 8645 H5 CYT 30-6. 916-3. 420-13.431 1.00 0.00 H ATOM 8646 H2'CYT 30-6.147-0. 360-17.185 1.00 0.00 H ATOM 8647 H02'CYT 30-7.023 1.329-18. 607 1.00 0.00 H ATOM 8648 H3'CYT 30-8.290-1. 200-16.589 1.00 0.00 H ATOM 8649 H03'CYT 30-9.739-0. 396-18.248 1.00 0.00 H TER ATOM 8650 05'GUA 1 19.610 9. 156 22.747 1.00 0.00 0 ATOM 8651 C5'GUA 1 20.428 9.638 23. 817 1.00 0.00 C ATOM 8652 C4'GUA 1 19.857 10.914 24.432 1.00 0.00 C ATOM 8653 04'GUA 1 19.746 11.963 23.459 1.00 0.00 O ATOM 8654 Cl'GUA 1 18.453 12.587 23.565 1. 00 0.00 C ATOM 8655 N9 GUA 1 17.589 12.223 22.423 1.00 0.00 N ATOM 8656 C4 GUA 1 16.680 13.040 21.787 1.00 0.00 C ATOM 8657 N3 GUA 1 16.406 14.325 22.110 1.00 0.00 N ATOM 8658 C2 GUA 1 15.479 14. 860 21.310 1.00 0.00 C ATOM 8659 N2 GUA 1 15.090 16. 122 21.491 1.00 0.00 N ATOM 8660 N1 GUA 1 14.873 14. 176 20.275 1.00 0.00 N ATOM 8661 C6 GUA 1 15.136 12.858 19.925 1.00 0.00 C ATOM 8662 06 GUA 1 14.539 12.340 18.983 1.00 0.00 0 ATOM 8663 C5 GUA 1 16.121 12. 281 20.770 1.00 0.00 C ATOM 8664 N7 GUA 1 16.666 10.994 20.759 1.00 0.00 N ATOM 8665 C8 GUA 1 17.499 11. 053 21. 743 1.00 0.00 C ATOM 8666 C2'GUA 1 17.867 12.093 24. 880 1. 00 0.00 C ATOM 8667 02'GUA 1 18.300 12.897 25.984 1.00 0.00 O ATOM 8668 C3'GUA 1 18. 442 10.693 24.946 1.00 0.00 C ATOM 8669 03'GUA 1 18.509 10. 287 26.317 1.00 0.00 O ATOM 8670 H5'GUA 1 18.790 8.840 23.135 1. 00 0.00 H ATOM 8671 1H5'GUA 1 21.428 9.844 23.435 1.00 0.00 H ATOM 8672 2H5'GUA 1 20.493 8.870 24.587 1.00 0.00 H ATOM 8673 H4'GUA 1 20. 496 11.245 25.249 1.00 0.00 H ATOM 8674 H1'GUA 1 18. 573 13.670 23.603 1. 00 0.00 H ATOM 8675 1H2 GUA 1 15.496 16.673 22.234 1. 00 0.00 H ATOM 8676 2H2 GUA 1 14.394 16. 528 20.883 1.00 0.00 H ATOM 8677 Hl GUA 1 14. 187 14. 654 19.711 1.00 0.00 H ATOM 8678 H8 GUA 1 18.109 10. 193 22.018 1. 00 0.00 H ATOM 8679 H2'GUA 1 16.776 12.057 24.820 1. 00 0.00 H ATOM 8680 H02'GUA 1 19.259 12. 906 25.972 1.00 0.00 H ATOM 8681 H3'GUA 1 17.882 9.992 24.326 1.00 0.00 H

ATOM 8682 P GUA 2 17.241 9.588 27.024 1.00 0.00 P ATOM 8683 01P GUA 2 17.604 9.275 28.425 1.00 0.00 0 ATOM 8684 02P GUA 2 16.747 8.514 26.133 1.00 0.00 0 ATOM 8685 05'GUA 2 16.150 10.772 27.037 1.00 0.00 0 ATOM 8686 C5'GUA 2 16.304 11.894 27.910 1.00 0.00 C ATOM 8687 C4'GUA 2 15.314 13.009 27.582 1.00 0.00 C ATOM 8688 04'GUA 2 15.466 13.480 26.239 1.00 0.00 0 ATOM 8689 C1'GUA 2 14.169 13.788 25.690 1.00 0.00 C ATOM 8690 N9 GUA 2 13.863 12.933 24.525 1.00 0.00 N ATOM 8691 C4 GUA 2 13.115 13.285 23.423 1.00 0.00 C ATOM 8692 N3 GUA 2 12.534 14.488 23.211 1.00 0.00 N ATOM 8693 C2 GUA 2 11.871 14.531 22.051 1.00 0.00 C ATOM 8694 N2 GUA 2 11.242 15.648 21.683 1.00 0.00 N ATOM 8695 N1 GUA 2 11.793 13.468 21.174 1.00 0.00 N ATOM 8696 C6 GUA 2 12.380 12.226 21.368 1.00 0.00 C ATOM 8697 06 GUA 2 12.249 11.343 20.523 1.00 0.00 O ATOM 8698 C5 GUA 2 13.087 12.170 22.600 1.00 0.00 C ATOM 8699 N7 GUA 2 13.810 11.118 23.171 1.00 0.00 N ATOM 8700 C8 GUA 2 14.219 11.648 24.274 1.00 0.00 C ATOM 8701 C2'GUA 2 13. 164 13.560 26.818 1.00 0.00 C ATOM 8702 02'GUA 2 12.925 14.761 27.561 1.00 0.00 0 ATOM 8703 C3'GUA 2 13. 880 12.519 27.655 1.00 0.00 C ATOM 8704 03'GUA 2 13.430 12.621 29.010 1.00 0.00 0 ATOM 8705 1H5'GUA 2 17.319 12.282 27.816 1.00 0.00 H ATOM 8706 2H5'GUA 2 16.143 11.568 28.938 1.00 0.00 H ATOM 8707 H4'GUA 2 15.453 13.840 28.272 1.00 0.00 H ATOM 8708 Hl'GUA 2 14.144 14.836 25.389 1.00 0.00 H ATOM 8709 1H2 GUA 2 11.266 16. 461 22.282 1.00 0.00 H ATOM 8710 2H2 GUA 2 10.743 15.681 20.805 1.00 0.00 H ATOM 8711 Hl GUA 2 11.268 13.580 20.319 1.00 0.00 H ATOM 8712 H8 GUA 2 14.829 11.083 24.979 1.00 0.00 H ATOM 8713 H2'GUA 2 12.233 13.152 26.418 1.00 0.00 H ATOM 8714 H02'GUA 2 12.408 14.520 28.334 1.00 0.00 H ATOM 8715 H3'GUA 2 13.764 11.515 27.246 1.00 0.00 H ATOM 8716 P CYT 3 12.227 11.693 29.543 1.00 0.00 P ATOM 8717 01P CYT 3 12.157 11. 826 31.015 1.00 0.00 O ATOM 8718 02P CYT 3 12.367 10.353 28.929 1.00 0.00 O ATOM 8719 05'CYT 3 10.931 12.404 28.905 1.00 0.00 0 ATOM 8720 C5'CYT 3 10.139 13.311 29.676 1.00 0.00 C ATOM 8721 C4'CYT 3 8.749 13.492 29.073 1.00 0.00 C ATOM 8722 04'CYT 3 8.806 14.106 27.777 1.00 0.00 O ATOM 8723 C1'CYT 3 7.913 13.414 26.881 1.00 0.00 C ATOM 8724 N1 CYT 3 8.664 12.623 25.879 1.00 0.00 N ATOM 8725 C6 CYT 3 9.885 12.093 26.178 1.00 0.00 C ATOM 8726 C2 CYT 3 8.077 12.431 24.635 1.00 0.00 C ATOM 8727 02 CYT 3 6.971 12.910 24.390 1.00 0.00 O ATOM 8728 N3 CYT 3 8.754 11.696 23.710 1.00 0.00 N ATOM 8729 C4 CYT 3 9.953 11.170 23.993 1.00 0.00 C ATOM 8730 N4 CYT 3 10.589 10.456 23.065 1.00 0.00 N ATOM 8731 C5 CYT 3 10.558 11.364 25. 273 1.00 0.00 C ATOM 8732 C2'CYT 3 7.069 12.508 27.767 1.00 0.00 C ATOM 8733 02'CYT 3 5.938 13.204 28.308 1.00 0.00 O ATOM 8734 C3'CYT 3 8.074 12.150 28.839 1.00 0.00 C ATOM 8735 03'CYT 3 7.373 11.771 30.028 1.00 0.00 O ATOM 8736 1H5'CYT 3 10.639 14.279 29.716 1.00 0.00 H ATOM 8737 2H5'CYT 3 10.038 12.921 30.690 1.00 0.00 H ATOM 8738 H4'CYT 3 8. 136 14.101 29.735 1.00 0.00 H ATOM 8739 H1'CYT 3 7.271 14.135 26.374 1.00 0.00 H ATOM 8740 H6 CYT 3 10.324 12.268 27.159 1.00 0.00 H ATOM 8741 1H4 CYT 3 11.493 10.055 23. 268 1.00 0.00 H

ATOM 8742 2H4 CYT 3 10.167 10.317 22.157 1.00 0.00 H ATOM 8743 H5 CYT 3 11.524 10.927 25.515 1.00 0.00 H ATOM 8744 H2'CYT 3 6.759 11.617 27.216 1.00 0.00 H ATOM 8745 H02'CYT 3 5.326 13.358 27.585 1.00 0.00 H ATOM 8746 H3'CYT 3 8.781 11.388 28.499 1.00 0.00 H ATOM 8747 P GUA 4 7.077 10.219 30.344 1.00 0.00 P ATOM 8748 O1P GUA 4 8.333 9.459 30.156 1.00 0.00 0 ATOM 8749 02P GUA 4 6.353 10.138 31.632 1.00 0.00 0 ATOM 8750 05'GUA 4 6.059 9.809 29.164 1.00 0.00 0 ATOM 8751 C5'GUA 4 4.731 10.336 29.140 1.00 0.00 C ATOM 8752 C4'GUA 4 4.096 10.219 27.756 1.00 0.00 C ATOM 8753 04'GUA 4 4.899 10.830 26.744 1.00 0.00 0 ATOM 8754 C1'GUA 4 4.734 10.099 25.510 1.00 0.00 C ATOM 8755 N9 GUA 4 6.020 9.574 25.009 1.00 0.00 N ATOM 8756 C4 GUA 4 6.255 9.067 23.752 1.00 0.00 C ATOM 8757 N3 GUA 4 5.344 8.969 22.759 1.00 0.00 N ATOM 8758 C2 GUA 4 5.860 8.436 21.650 1.00 0.00 C ATOM 8759 N2 GUA 4 5.089 8.262 20.578 1.00 0.00 N ATOM 8760 N1 GUA 4 7.178 8.033 21.535 1.00 0.00 N ATOM 8761 C6 GUA 4 8.132 8.125 22.540 1.00 0.00 C ATOM 8762 06 GUA 4 9.282 7.744 22.335 1.00 0.00 0 ATOM 8763 C5 GUA 4 7.588 8.690 23.725 1.00 0.00 C ATOM 8764 N7 GUA 4 8.197 8.953 24. 957 1.00 0.00 N ATOM 8765 C8 GUA 4 7.220 9.459 25.631 1.00 0.00 C ATOM 8766 C2'GUA 4 3.769 8.956 25.818 1.00 0.00 C ATOM 8767 02'GUA 4 2.416 9.318 25.514 1.00 0.00 O ATOM 8768 C3'GUA 4 3.979 8.776 27.307 1.00 0.00 C ATOM 8769 03'GUA 4 2.798 8.203 27. 876 1.00 0.00 O ATOM 8770 1H5'GUA 4 4.760 11.388 29.427 1.00 0.00 H ATOM 8771 2H5'GUA 4 4.119 9.790 29.859 1.00 0.00 H ATOM 8772 H4'GUA 4 3.111 10.683 27.762 1.00 0.00 H ATOM 8773 H1'GUA 4 4.292 10.754 24.759 1.00 0.00 H ATOM 8774 1H2 GUA 4 4.117 8.533 20. 607 1.00 0.00 H ATOM 8775 2H2 GUA 4 5.474 7.857 19.739 1.00 0.00 H ATOM 8776 H1 GUA 4 7.495 7.641 20.659 1.00 0.00 H ATOM 8777 H8 GUA 4 7.353 9.777 26.665 1.00 0.00 H ATOM 8778 H2'GUA 4 4.066 8.052 25.278 1.00 0.00 H ATOM 8779 H02'GUA 4 2.327 9.311 24.558 1.00 0.00 H ATOM 8780 H3'GUA 4 4.880 8.199 27.526 1.00 0.00 H ATOM 8781 P CYT 5 2.490 6.632 27.702 1.00 0.00 P ATOM 8782 01P CYT 5 1.288 6.304 28.502 1.00 0.00 O ATOM 8783 02P CYT 5 3.748 5.884 27.922 1.00 0.00 0 ATOM 8784 05'CYT 5 2.105 6.520 26.143 1.00 0.00 0 ATOM 8785 C5'CYT 5 0.837 6.985 25.669 1.00 0.00 C ATOM 8786 C4'CYT 5 0.568 6.520 24.241 1.00 0.00 C ATOM 8787 04'CYT 5 1. 522 7.058 23.319 1.00 0.00 0 ATOM 8788 C1'CYT 5 1.884 6.048 22.356 1.00 0.00 C ATOM 8789 N1 CYT 5 3.314 5.684 22.471 1.00 0. 00 N ATOM 8790 C6 CYT 5 3.958 5.742 23.673 1.00 0.00 C ATOM 8791 C2 CYT 5 3.969 5.272 21.317 1.00 0. 00 C ATOM 8792 02 CYT 5 3.368 5.230 20.245 1.00 0.00 0 ATOM 8793 N3 CYT 5 5.280 4.923 21.411 1.00 0.00 N ATOM 8794 C4 CYT 5 5.925 4.974 22.583 1.00 0. 00 C ATOM 8795 N4 CYT 5 7.207 4.616 22.636 1.00 0.00 N ATOM 8796 C5 CYT 5 5.254 5.399 23.774 1.00 0.00 C ATOM 8797 C2'CYT 5 0.990 4.844 22.642 1.00 0.00 C ATOM 8798 02'CYT 5-0.216 4.889 21.870 1. 00 0. 00 O ATOM 8799 C3'CYT 5 0.715 5.014 24.123 1.00 0.00 C ATOM 8800 03'CYT 5-0.543 4.409 24.435 1.00 0.00 O ATOM 8801 1H5'CYT 5 0.822 8.074 25. 698 1. 00 0.00 H

ATOM 8802 2H5'CYT 5 0.052 6.601 26.321 1.00 0.00 H ATOM 8803 H4'CYT 5-0.435 6.816 23. 940 1.00 0.00 H ATOM 8804 Hl'CYT 5 1.683 6.417 21.350 1.00 0.00 H ATOM 8805 H6 CYT 5 3.417 6.069 24.561 1.00 0.00 H ATOM 8806 1H4 CYT. 5 7.682 4.316 21.797 1.00 0.00 H ATOM 8807 2H4 CYT 5 7.704 4.646 23. 515 1.00 0.00 H ATOM 8808 H5 CYT 5 5.774 5.443 24.730 1.00 0.00 H ATOM 8809 H2'CYT 5 1.539 3.916 22.462 1.00 0. 00 H ATOM 8810 H02'CYT 5-0.660 5.713 22.082 1.00 0.00 H ATOM 8811 H3'CYT 5 1.532 4.631 24.736 1.00 0.00 H ATOM 8812 P URI 6-0.601 3.016 25.241 1.00 0.00 P ATOM 8813 01P URI 6 0.449 3.039 26.284 1.00 0.00 0 ATOM 8814 02P URI 6-2.009 2.756 25. 616 1.00 0.00 0 ATOM 8815 05'URI 6-0.169 1.947 24.117 1.00 0.00 0 ATOM 8816 C5'URI 6-1.060 1.619 23. 047 1. 00- 0. 00 C ATOM 8817 C4'URI 6-0.335 0.902 21. 911 1.00 0.00 C ATOM 8818 04'URI 6 0.711 1.711 21.356 1.00 0.00 0 ATOM 8819 C1'URI 6 1.873 0.894 21.114 1.00 0.00 C ATOM 8820 N1 URI 6 2.987 1.254 22.021 1.00 0.00 N ATOM 8821 C6 URI 6 2.747 1.784 23.261 1.00 0.00 C ATOM 8822 C2 URI 6 4.277 1.038 21.566 1.00 0.00 C ATOM 8823 02 URI 6 4.512 0.558 20.459 1.00 0.00 0 ATOM 8824 N3 URI 6 5.293 1.388 22.435 1.00 0.00 N ATOM 8825 C4 URI 6 5.139 1.927 23.700 1.00 0.00 C ATOM 8826 04 URI 6 6.119 2.201 24.387 1.00 0.00 0 ATOM 8827 C5 URI 6 3.762 2.118 24.094 1.00 0.00 C ATOM 8828 C2'URI 6 1.423-0. 544 21.341 1.00 0.00 C ATOM 8829 02'URI 6 0. 876-1. 119 20. 148 1.00 0.00 0 ATOM 8830 C3'URI 6 0.365-0. 352 22.406 1.00 0. 00 C ATOM 8831 03'URI 6-0.554-1. 448 22.351 1.00 0.00 0 ATOM 8832 1H5'URI 6-1.507 2.534 22.660 1.00 0.00 H ATOM 8833 2H5'URI 6-1.849 0.971 23.429 1.00 0.00 H ATOM 8834 H4'URI 6-1.044 0.642 21.128 1.00 0.00 H ATOM 8835 Hl'URI 6 2.193 1.013 20.079 1.00 0.00 H ATOM 8836 H6 URI 6 1.719 1.938 23.586 1.00 0.00 H ATOM 8837 H3 URI 6 6.239 1.236 22.116 1.00 0.00 H ATOM 8838 H5 URI 6 3.536 2.538 25.074 1.00 0.00 H ATOM 8839 H2'URI 6 2.249-1. 144 21.725 1.00 0.00 H ATOM 8840 H02'URI 6 1. 610-1. 288 19.551 1.00 0.00 H ATOM 8841 H3'URI 6 0.802-0. 217 23.397 1.00 0.00 H ATOM 8842 P CYT 7-0.334-2. 746 23.280 1.00 0.00 P ATOM 8843 01P CYT 7 0.016-2. 286 24.643 1. 00 0.00 0 ATOM 8844 02P CYT 7-1.483-3. 657 23.081 1.00 0. 00 0 ATOM 8845 05'CYT 7 0.972-3. 426 22.628 1.00 0.00 0 ATOM 8846 C5'CYT 7 0.907-4. 022 21.329 1.00 0.00 C ATOM 8847 C4'CYT 7 2.296-4. 218 20.727 1.00 0.00 C ATOM 8848 04'CYT 7 3.028-2. 990 20.664 1.00 0.00 O ATOM 8849 Cl'CYT 7 4.427-3. 261 20.892 1.00 0.00 C ATOM 8850 N1 CYT 7 4.939-2. 551 22.085 1.00 0.00 N ATOM 8851 C6 CYT 7 4.103-2. 148 23.088 1.00 0.00 C ATOM 8852 C2 CYT 7 6.306-2. 329 22.151 1.00 0.00 C ATOM 8853 02 CYT 7 7.036-2. 702 21.236 1.00 0. 00 O ATOM 8854 N3 CYT 7 6.807-1. 698 23.246 1.00 0.00 N ATOM 8855 C4 CYT 7 6.003-1. 299 24.238 1.00 0.00 C ATOM 8856 N4 CYT 7 6.531-0. 688 25.297 1.00 0.00 N ATOM 8857 C5 CYT 7 4.591-1. 522 24.176 1.00 0.00 C ATOM 8858 C2'CYT 7 4.542-4. 773 21.074 1.00 0.00 C ATOM 8859 02'CYT 7 4.827-5. 431 19.833 1.00 0. 00 0 ATOM 8860 C3'CYT 7 3.160-5. 119 21.587 1.00 0.00 C ATOM 8861 03'CYT 7 2.877-6. 485 21. 267 1.00 0. 00 0

ATOM 8862 1H5'CYT 7 0.324-3. 378 20.671 1.00 0.00 H ATOM 8863 2H5'CYT 7 0.414-4. 991 21.407 1.00 0.00 H ATOM 8864 H4'CYT 7 2.209-4. 637 19.726 1.00 0.00 H ATOM 8865 Hl'CYT 7 5.000-2. 958 20.015 1.00 0.00 H ATOM 8866 H6 CYT 7 3. 033-2. 336 23.009 1.00 0.00 H ATOM 8867 1H4 CYT 7 5.936-0. 384 26.054 1.00 0.00 H ATOM 8868 2H4 CYT 7 7.529-0. 533 25.344 1.00 0.00 H ATOM 8869 H5 CYT 7 3.933-1. 196 24.982 1.00 0.00 H ATOM 8870 H2'CYT 7 5.299-5. 007 21.827 1.00 0.00 H ATOM 8871 H02'CYT 7 5.722-5. 192 19.583 1.00 0.00 H ATOM 8872 H3'CYT 7 3.051-4. 902 22.652 1.00 0.00 H ATOM 8873 P ADE 8 3.261-7. 659 22.302 1.00 0.00 P ATOM 8874 01P ADE 8 2.621-7. 358 23.602 1.00 0.00 0 ATOM 8875 02P ADE 8 3.011-8. 960 21.641 1.00 0.00 O ATOM 8876 05'ADE 8 4.852-7. 475 22.470 1.00 0.00 0 ATOM 8877 C5'ADE 8 5.747-7. 844 21.416 1.00 0.00 C ATOM 8878 C4'ADE 8 7.205-7. 644 21.823 1.00 0.00 C ATOM 8879 04'ADE 8 7.489-6. 267 22.119 1.00 0.00 O ATOM 8880 C1'ADE 8 8.222-6. 186 23.356 1.00 0.00 C ATOM 8881 N9 ADE 8 7.369-5. 679 24.452 1.00 0.00 N ATOM 8882 C4 ADE 8 7.791-5. 203 25.676 1.00 0.00 C ATOM 8883 N3 ADE 8 9.067-5. 111 26.105 1.00 0.00 N ATOM 8884 C2 ADE 8 9.128-4. 609 27.336 1.00 0.00 C ATOM 8885 N1 ADE 8 8.106-4. 225 28.102 1.00 0.00 N ATOM 8886 C6 ADE 8 6.844-4. 327 27.652 1.00 0. 00 C ATOM 8887 N6 ADE 8 5.837-3. 937 28.433 1.00 0.00 N ATOM 8888 C5 ADE 8 6.656-4. 844 26.366 1.00 0.00 C ATOM 8889 N7 ADE 8 5.511-5. 084 25.601 1.00 0.00 N ATOM 8890 C8 ADE 8 6.019-5. 564 24.516 1.00 0.00 C ATOM 8891 C2'ADE 8 8.696-7. 602 23.638 1.00 0.00 C ATOM 8892 02'ADE 8 9.908-7. 903 22. 935 1.00 0.00 0 ATOM 8893 C3'ADE 8 7. 525-8. 396 23.106 1.00 0.00 C ATOM 8894 03'ADE 8 7.969-9. 717 22.780 1.00 0.00 0 ATOM 8895 lH5'ADE 8 5.536-7. 234 20. 538 1.00 0.00 H ATOM 8896 2H5'ADE 8 5.589-8. 893 21.167 1.00 0.00 H ATOM 8897 H4'ADE 8 7.861-7. 985 21.023 1.00 0.00 H ATOM 8898 H1'ADE 8 9.084-5. 534 23.230 1.00 0.00 H ATOM 8899 H2 ADE 8 10.123-4. 500 27.768 1.00 0.00 H ATOM 8900 1H6 ADE 8 6.026-3. 570 29.355 1. 00 0.00 H ATOM 8901 2H6 ADE 8 4.885-4. 007 28.103 1.00 0.00 H ATOM 8902 H8 ADE 8 5.386-5. 872 23.685 1.00 0.00 H ATOM 8903 H2'ADE 8 8.811-7. 757 24.713 1.00 0.00 H ATOM 8904 H02'ADE 8 10.010-8. 858 22.941 1.00 0.00 H ATOM 8905 H3'ADE 8 6.687-8. 394 23.800 1.00 0.00 H ATOM 8906 P ADE 9 6.930-10. 950 22.764 1.00 0.00 P ATOM 8907 O1P ADE 9 6.013-10. 770 21.616 1.00 0.00 0 ATOM 8908 02P ADE 9 7.702-12. 205 22.901 1.00 0.00 0 ATOM 8909 05'ADE 9 6.089-10. 724 24.121 1.00 0.00 0 ATOM 8910 C5'ADE 9 5.144-11. 705 24.566 1.00 0.00 C ATOM 8911 C4'ADE 9 4.438-11. 277 25.854 1.00 0.00 C ATOM 8912 04'ADE 9 5. 380-10. 966 26.887 1.00 0. 00 0 ATOM 8913 C1'ADE 9 5.456-9. 541 27.064 1.00 0.00 C ATOM 8914 N9 ADE 9 6.861-9. 091 27.073 1.00 0.00 N ATOM 8915 C4 ADE 9 7. 475-8. 337 28. 044 1.00 0.00 C ATOM 8916 N3 ADE 9 6. 898-7. 845 29.154 1.00 0.00 N ATOM 8917 C2 ADE 9 7.767-7. 162 29.887 1.00 0.00 C ATOM 8918 N1 ADE 9 9.057-6. 948 29.621 1.00 0.00 N ATOM 8919 C6 ADE 9 9.612-7. 449 28.505 1.00 0.00 C ATOM 8920 N6 ADE 9 10.903-7. 228 28.259 1.00 0.00 N ATOM 8921 C5 ADE 9 8.786-8. 191 27.654 1.00 0.00 C

ATOM 8922 N7 ADE 9 9.019-8. 844 26.441 1.00 0.00 N ATOM 8923 C8 ADE 9 7.852-9. 333 26. 183 1.00 0.00 C ATOM 8924 C2'ADE 9 4.683-8. 931 25.899 1.00 0.00 C ATOM 8925 02'ADE 9 4.093-7. 675 26.251 1.00 0.00 0 ATOM 8926 C3'ADE 9 3.633-9. 995 25.655 1.00 0.00 C ATOM 8927 03'ADE 9 2.643-9. 881 26.694 1.00 0.00 0 ATOM 8928 1H5'ADE 9 5.667-12. 644 24.745 1.00 0.00 H ATOM 8929 2H5'ADE 9 4.397-11. 858 23.786 1.00 0.00 H ATOM 8930 H4'ADE 9 3.786-12. 078 26.193 1.00 0.00 H ATOM 8931 Hl'ADE 9 4.977-9. 263 28.003 1.00 0.00 H ATOM 8932 H2 ADE 9 7.388-6. 737 30.811 1.00 0.00 H ATOM 8933 1H6 ADE 9 11.329-7. 602 27.424 1.00 0.00 H ATOM 8934 2H6 ADE 9 11.455-6. 687 28.909 1.00 0.00 H ATOM 8935 H8 ADE 9 7.671-9. 915 25. 282 1.00 0.00 H ATOM 8936 H2'ADE 9 5.327-8. 837 25.024 1.00 0.00 H ATOM 8937 H02'ADE 9 3.505-7. 834 26.993 1.00 0.00 H ATOM 8938 H3'ADE 9 3.202-9. 929 24.656 1.00 0.00 H ATOM 8939 P URI 10 1.700-11. 121 27.116 1.00 0.00 P ATOM 8940 01P URI 10 0.634-10. 610 28.006 1.00 0.00 0 ATOM 8941 02P URI 10 1.341-11. 872 25.891 1.00 0.00 O ATOM 8942 05'URI 10 2.700-12. 031 27.992 1.00 0.00 O ATOM 8943 C5'URI 10 2.205-12. 921 28.997 1.00 0.00 C ATOM 8944 C4'URI 10 2.824-12. 620 30.361 1.00 0.00 C ATOM 8945 04'URI 10 2.425-11. 329 30.846 1.00 0.00 0 ATOM 8946 C1'URI 10 1.570-11. 481 31.994 1.00 0.00 C ATOM 8947 N1 URI 10 0.410-10. 565 31.924 1.00 0.00 N ATOM 8948 C6 URI 10 0.135-9. 865 30.781 1.00 0.00 C ATOM 8949 C2 URI 10-0.387-10. 447 33.052 1.00 0.00 C ATOM 8950 02 URI 10-0.157-11. 068 34.088 1.00 0.00 0 ATOM 8951 N3 URI 10-1.463-9. 586 32.947 1.00 0.00 N ATOM 8952 C4 URI 10-1.811-8. 844 31.831 1.00 0.00 C ATOM 8953 04 URI 10-2.794-8. 108 31.850 1.00 0.00 O ATOM 8954 C5 URI 10-0.926-9. 029 30.704 1.00 0.00 C ATOM 8955 C2'URI 10 1. 123-12. 936 31.979 1.00 0.00 C ATOM 8956 02'URI 10 0.810-13. 410 33.294 1.00 0.00 0 ATOM 8957 C3'URI 10 2.354-13. 616 31.414 1.00 0.00 C ATOM 8958 03'URI 10 3.348-13. 684 32.446 1.00 0.00 0 ATOM 8959 1H5'URI 10 2.449-13. 945 28.714 1.00 0.00 H ATOM 8960 2H5'URI 10 1.122-12. 820 29.065 1.00 0.00 H ATOM 8961 H4'URI 10 3.908-12. 654 30.283 1.00 0.00 H ATOM 8962 Hl'URI 10 2.138-11. 284 32.903 1.00 0.00 H ATOM 8963 H6 URI 10 0.786-9. 979 29.915 1.00 0.00 H ATOM 8964 H3 URI 10-2.052-9. 490 33.761 1.00 0.00 H ATOM 8965 H5 URI 10-1.117-8. 491 29.776 1.00 0.00 H ATOM 8966 H2'URI 10 0.277-13. 065 31.297 1.00 0.00 H ATOM 8967 H02'URI 10 0.178-12. 795 33.676 1.00 0.00 H ATOM 8968 H3'URI 10 2.129-14. 593 30.987 1.00 0.00 H ATOM 8969 P GUA 11 4.679-14. 575 32.257 1.00 0.00 P ATOM 8970 01P GUA 11 5.511-14. 424 33.472 1.00 0.00 0 ATOM 8971 02P GUA 11 4.273-15. 925 31.805 1.00 0.00 0 ATOM 8972 05'GUA 11 5.433-13. 836 31.038 1.00 0.00 O ATOM 8973 C5'GUA 11 5.640-14. 508 29.790 1.00 0.00 C ATOM 8974 C4'GUA 11 6.798-13. 896 29.006 1.00 0.00 C ATOM 8975 04'GUA 11 6.549-12. 522 28.673 1.00 0.00 0 ATOM 8976 Cl'GUA 11 7.710-11. 734 28.992 1.00 0.00 C ATOM 8977 N9 GUA 11 7.488-10. 933 30.209 1.00 0.00 N ATOM 8978 C4 GUA 11 8.405-10. 124 30.835 1.00 0. 00 C ATOM 8979 N3 GUA 11 9.686-9. 935 30.449 1.00 0.00 N ATOM 8980 C2 GUA 11 10.335-9. 091 31.255 1.00 0.00 C ATOM 8981 N2 GUA 11 11.612-8. 795 31.019 1.00 0.00 N

ATOM 8982 N1 GUA 11 9.758-8. 484 32.352 1.00 0.00 N ATOM 8983 C6 GUA 11 8.445-8. 662 32.767 1.00 0.00 C ATOM 8984 06 GUA 11 8.027-8. 074 33.760 1.00 0.00 O ATOM 8985 C5 GUA 11 7.748-9. 559 31.917 1.00 0.00 C ATOM 8986 N7 GUA 11 6.426-10. 007 31.978 1.00 0.00 N ATOM 8987 C8 GUA 11 6.369-10. 793 30.957 1.00 0.00 C ATOM 8988 C2'GUA 11 8.835-12. 738 29.195 1.00 0.00 C ATOM 8989 02'GUA 11 9.427-13. 127 27.949 1.00 0.00 O ATOM 8990 C3'GUA 11 8.072-13. 876 29.836 1.00 0.00 C ATOM 8991 03'GUA 11 8.783-15. 097 29.617 1.00 0.00 O ATOM 8992 1H5'GUA 11 4.731-14. 440 29.193 1.00 0.00 H ATOM 8993 2H5'GUA 11 5.860-15. 558 29.985 1.00 0.00 H ATOM 8994 H4'GUA 11 6.964-14. 464 28.093 1.00 0.00 H ATOM 8995 Hl'GUA 11 7.950-11. 072 28.160 1.00 0.00 H ATOM 8996 1H2 GUA 11 12.103-8. 156 31.628 1.00 0.00 H ATOM 8997 2H2 GUA 11 12.089-9. 210 30.231 1.00 0.00 H ATOM 8998 H1 GUA 11 10.317-7. 857 32.911 1.00 0.00 H ATOM 8999 H8 GUA 11 5.457-11. 330 30.706 1.00 0.00 H ATOM 9000 H2'GUA 11 9.585-12. 339 29. 884 1.00 0.00 H ATOM 9001 H02'GUA 11 9.912-12. 370 27.615 1.00 0.00 H ATOM 9002 H3'GUA 11 7.872-13. 688 30.892 1.00 0.00 H ATOM 9003 P CYT 12 9.443-15. 881 30.857 1.00 0.00 P ATOM 9004 01P CYT 12 10.047-17. 132 30.346 1.00 0.00 O ATOM 9005 02P CYT 12 8.450-15. 935 31.954 1.00 0.00 0 ATOM 9006 05'CYT 12 10.631-14. 889 31.301 1.00 0.00 0 ATOM 9007 C5'CYT 12 11.813-14. 774 30.504 1.00 0.00 C ATOM 9008 C4'CYT 12 12. 777-13.736 31.070 1.00 0.00 C ATOM 9009 04'CYT 12 12.198-12. 429 31.103 1.00 0.00 O ATOM 9010 C1'CYT 12 12.642-11. 741 32.291 1.00 0.00 C ATOM 9011 N1 CYT 12 11.506-11. 413 33.181 1.00 0.00 N ATOM 9012 C6 CYT 12 10.267-11. 952 32.974 1.00 0.00 C ATOM 9013 C2 CYT 12 11.744-10. 528 34.227 1.00 0.00 C ATOM 9014 02 CYT 12 12.870-10. 064 34.404 1.00 0.00 0 ATOM 9015 N3 CYT 12 10.707-10. 204 35.045 1.00 0.00 N ATOM 9016 C4 CYT 12 9.489-10. 723 34.853 1.00 0.00 C ATOM 9017 N4 CYT 12 8.494-10. 374 35.666 1.00 0.00 N ATOM 9018 C5 CYT 12 9. 238-11. 637 33.783 1.00 0.00 C ATOM 9019 C2'CYT 12 13.628-12. 682 32.981 1.00 0.00 C ATOM 9020 02'CYT 12 14.972-12. 437 32.553 1.00 0.00 0 ATOM 9021 C3'CYT 12 13.128-14. 033 32.515 1.00 0.00 C ATOM 9022 03'CYT 12 14.209-14. 969 32.543 1.00 0.00 0 ATOM 9023 lH5'CYT 12 11.533-14. 485 29.491 1.00 0.00 H ATOM 9024 2H5'CYT 12 12.313-15. 742 30.472 1.00 0.00 H ATOM 9025 H4'CYT 12 13.686-13. 713 30.470 1.00 0.00 H ATOM 9026 H1'CYT 12 13.157-10. 824 32.005 1.00 0.00 H ATOM 9027 H6 CYT 12 10.107-12. 641 32.144 1.00 0.00 H ATOM 9028 1H4 CYT 12 7. 569-10. 754 35.526 1.00 0.00 H ATOM 9029 2H4 CYT 12 8.664-9. 724 36. 421 1.00 0.00 H ATOM 9030 H5 CYT 12 8.249-12. 066 33.628 1.00 0.00 H ATOM 9031 H2'CYT 12 13.539-12. 594 34.066 1.00 0.00 H ATOM 9032 H02'CYT 12 15.213-11. 561 32.863 1.00 0.00 H ATOM 9033 H3'CYT 12 12.264-14. 367 33.092 1.00 0.00 H ATOM 9034 P URI 13 14.334-16. 033 33.744 1.00 0. 00 P ATOM 9035 01P URI 13 15.407-16. 994 33.403 1.00 0.00 0 ATOM 9036 02P URI 13 12. 978-16. 527 34.071 1.00 0.00 O ATOM 9037 05'URI 13 14. 844-15. 117 34.964 1.00 0.00 O ATOM 9038 C5'URI 13 16.189-14. 633 34.993 1.00 0.00 C ATOM 9039 C4'URI 13 16.384-13. 581 36.080 1.00 0.00 C ATOM 9040 04'URI 13 15.546-12. 439 35.874 1.00 0. 00 0 ATOM 9041 C1'URI 13 15.087-11. 951 37.152 1.00 0.00 C

ATOM 9042 N1 URI 13 13.613-12. 029 37.267 1.00 0.00 N ATOM 9043 C6 URI 13 12.884-12. 903 36.502 1.00 0.00 C ATOM 9044 C2 URI 13 13.001-11. 182 38.176 1.00 0.00 C ATOM 9045 02 URI 13 13.638-10. 396 38.874 1.00 0.00 0 ATOM 9046 N3 URI 13 11.626-11. 273 38.259 1.00 0.00 N ATOM 9047 C4 URI 13 10.816-12. 122 37.526 1.00 0.00 C ATOM 9048 04 URI 13 9.597-12. 110 37.678 1.00 0.00 0 ATOM 9049 C5 URI 13 11.535-12. 971 36.603 1.00 0.00 C ATOM 9050 C2'URI 13 15.765-12. 822 38.207 1.00 0. 00 C ATOM 9051 02'URI 13 17.008-12. 254 38.637 1.00 0.00 0 ATOM 9052 C3'URI 13 15.976-14. 110 37.441 1.00 0.00 C ATOM 9053 03'URI 13 17.079-14. 817 38.015 1.00 0.00 0 ATOM 9054 1H5'URI 13 16.431-14. 192 34.025 1.00 0.00 H ATOM 9055 2H5'URI 13 16.863-15. 468 35.182 1.00 0. 00 H ATOM 9056 H4'URI 13 17.426-13. 265 36.105 1.00 0.00 H ATOM 9057 Hl'URI 13 15.407-10. 916 37.278 1.00 0.00 H ATOM 9058 H6 URI 13 13.399-13. 559 35.800 1.00 0.00 H ATOM 9059 H3 URI 13 11.168-10. 664 38.920 1.00 0.00 H ATOM 9060 H5 URI 13 10.984-13. 676 35.981 1.00 0.00 H ATOM 9061 H2'URI 13 15.093-12. 985 39.052 1.00 0.00 H ATOM 9062 H02'URI 13 17.511-12. 954 39.058 1.00 0.00 H ATOM 9063 H3'URI 13 15.066-14. 711 37.393 1.00 0.00 H ATOM 9064 P CYT 14 16.829-15. 915 39.166 1.00 0.00 P ATOM 9065 01P CYT 14 18. 118-16.582 39.457 1.00 0.00 0 ATOM 9066 02P CYT 14 15.649-16. 724 38.786 1.00 0.00 0 ATOM 9067 05'CYT 14 16.430-15. 008 40.435 1.00 0.00 0 ATOM 9068 C5'CYT 14 17.440-14. 367 41.220 1.00 0.00 C ATOM 9069 C4'CYT 14 16.834-13. 552 42.359 1.00 0.00 C ATOM 9070 04'CYT 14 15.983-12. 510 41.871 1.00 0.00 0 ATOM 9071 C1'CYT 14 14.851-12. 366 42.754 1.00 0.00 C ATOM 9072 N1 CYT 14 13.579-12. 659 42.059 1.00 0.00 N ATOM 9073 C6 CYT 14 13.530-13. 541 41.019 1.00 0.00 C ATOM 9074 C2 CYT 14 12.437-12. 014 42.516 1.00 0.00 C ATOM 9075 02 CYT 14 12.505-11. 227 43. 459 1. 00 0.00 0 ATOM 9076 N3 CYT 14 11.255-12. 283 41.901 1.00 0.00 N ATOM 9077 C4 CYT 14 11.192-13. 146 40.881 1.00 0.00 C ATOM 9078 N4 CYT 14 10.017-13. 386 40.303 1.00 0.00 N ATOM 9079 C5 CYT 14 12.364-13. 812 40.405 1.00 0.00 C ATOM 9080 C2'CYT 14 15.075-13. 349 43.899 1.00 0.00 C ATOM 9081 02'CYT 14 15.756-12. 730 44.997 1.00 0.00 0 ATOM 9082 C3'CYT 14 15.931-14. 404 43.229 1.00 0.00 C ATOM 9083 03'CYT 14 16.724-15. 056 44.224 1.00 0.00 0 ATOM 9084 1H5'CYT 14 18.024-13. 706 40.580 1.00 0.00 H ATOM 9085 2H5'CYT 14 18.098-15. 128 41.639 1.00 0.00 H ATOM 9086 H4'CYT 14 17.627-13. 117 42.965 1.00 0. 00 H ATOM 9087 Hl'CYT 14 14.825-11. 350 43.148 1.00 0.00 H ATOM 9088 H6 CYT 14 14.443-14. 033 40.683 1.00 0.00 H ATOM 9089 1H4 CYT 14 9.956-14. 036 39.532 1.00 0.00 H ATOM 9090 2H4 CYT 14 9.185-12. 922 40.640 1.00 0.00 H ATOM 9091 H5 CYT 14 12.315-14. 519 39.579 1.00 0.00 H ATOM 9092 H2'CYT 14 14.122-13. 779 44.218 1.00 0.00 H ATOM 9093 H02'CYT 14 15.145-12. 104 45.394 1.00 0.00 H ATOM 9094 H3'CYT 14 15.333-15. 103 42.641 1.00 0.00 H ATOM 9095 P URI 15 16.173-16. 376 44.963 1.00 0.00 P ATOM 9096 01P URI 15 17.126-16. 740 46.035 1.00 0. 00 O ATOM 9097 02P URI 15 15.811-17. 370 43.928 1.00 0.00 0 ATOM 9098 05'URI 15 14.815-15. 849 45.651 1. 00 0. 00 0 ATOM 9099 C5'URI 15 14.863-15. 017 46.814 1.00 0.00 C ATOM 9100 C4'URI 15 13.475-14. 526 47.217 1. 00 0.00 C

ATOM 9101 04'URI 15 12.875-13. 711 46.199 1.00 0.00 0 ATOM 9102 C1'URI 15 11.477-14. 054 46.078 1.00 0.00 C ATOM 9103 N1 URI 15 11. 200-14. 732 44.792 1.00 0. 00 N ATOM 9104 C6 URI 15 12.141-15. 533 44.204 1.00 0.00 C ATOM 9105 C2 URI 15 9.956-14. 536 44.215 1.00 0.00 C ATOM 9106 02 URI 15 9.095-13. 829 44.732 1.00 0.00 O ATOM 9107 N3 URI 15 9.732-15. 194 43.020 1.00 0.00 N ATOM 9108 C4 URI 15 10.627-16. 019 42.361 1.00 0.00 C ATOM 9109 04 URI 15 10.320-16. 552 41.297 1.00 0.00 0 ATOM 9110 C5 URI 15 11.897-16. 167 43.035 1.00 0.00 C ATOM 9111 C2'URI 15 11.179-14. 976 47.255 1.00 0.00 C ATOM 9112 02'URI 15 10.840-14. 235 48.434 1.00 0.00 O ATOM 9113 C3'URI 15 12.509-15. 683 47.399 1.00 0.00 C ATOM 9114 03'URI 15 12.633-16. 184 48.733 1.00 0.00 O ATOM 9115 1H5'URI 15 15.500-14. 156 46.611 1.00 0.00 H ATOM 9116 2H5'URI 15 15.290-15. 588 47.639 1.00 0.00 H ATOM 9117 H4'URI 15 13.541-13. 955 48.141 1.00 0.00 H ATOM 9118 H1'URI 15 10.871-13. 151 46.157 1.00 0.00 H ATOM 9119 H6 URI 15 13.110-15. 663 44.686 1.00 0.00 H ATOM 9120 H3 URI 15 8.830-15. 060 42.587 1.00 0.00 H ATOM 9121 H5 URI 15 12.667-16. 802 42.600 1.00 0.00 H ATOM 9122 H2'URI 15 10.391-15. 686 46.993 1.00 0.00 H ATOM 9123 H02'URI 15 10.018-13. 772 48.253 1.00 0.00 H ATOM 9124 H3'URI 15 12.645-16. 457 46.639 1.00 0.00 H ATOM 9125 P URI 16 11.972-17. 595 49.137 1.00 0.00 P ATOM 9126 01P URI 16 12.058-18. 501 47.969 1.00 0.00 O ATOM 9127 02P URI 16 12.536-18. 014 50.440 1.00 0.00 0 ATOM 9128 05'URI 16 10.426-17. 203 49.359 1.00 0.00 O ATOM 9129 C5'URI 16 9.488-18. 170 49.839 1.00 0.00 C ATOM 9130 C4'URI 16 8.865-17. 732 51.158 1.00 0.00 C ATOM 9131 04'URI 16 9.873-17. 396 52.124 1.00 0.00 O ATOM 9132 C1'URI 16 9.676-16. 054 52.581 1.00 0.00 C ATOM 9133 N1 URI 16 10.969-15. 385 52.852 1.00 0.00 N ATOM 9134 C6 URI 16 11.876-15. 167 51.848 1.00 0.00 C ATOM 9135 C2 URI 16 11.229-14. 995 54.155 1.00 0.00 C ATOM 9136 02 URI 16 10.426-15. 181 55.069 1.00 0.00 O ATOM 9137 N3 URI 16 12.448-14. 380 54.374 1.00 0.00 N ATOM 9138 C4 URI 16 13.417-14. 123 53.420 1.00 0.00 C ATOM 9139 04 URI 16 14.469-13. 569 53.730 1.00 0.00 O ATOM 9140 C5 URI 16 13.064-14. 562 52.089 1.00 0.00 C ATOM 9141 C2'URI 16 8.915-15. 358 51.465 1.00 0.00 C ATOM 9142 02'URI 16 8.160-14. 243 51.954 1.00 0.00 O ATOM 9143 C3'URI 16 8.013-16. 475 50.973 1.00 0.00 C ATOM 9144 03'URI 16 6.881-16. 568 51.845 1.00 0.00 O ATOM 9145 1H5'URI 16 9.992-19. 121 49.979 1.00 0.00 H ATOM 9146 2H5'URI 16 8.698-18. 300 49.103 1. 00 0. 00 H ATOM 9147 H4'URI 16 8.245-18. 536 51.552 1.00 0.00 H ATOM 9148 H1'URI 16 9.069-16. 062 53.487 1. 00 0.00 H ATOM 9149 H6 URI 16 11. 638-15. 486 50.834 1.00 0.00 H ATOM 9150 H3 URI 16 12.650-14. 091 55.320 1.00 0.00 H ATOM 9151 H5 URI 16 13.762-14. 403 51.268 1. 00 0.00 H ATOM 9152 H2'URI 16 9.601-15. 053 50.670 1.00 0. 00 H ATOM 9153 H02'URI 16 7.559-14. 578 52.624 1.00 0.00 H ATOM 9154 H3'URI 16 7.718-16. 332 49.932 1.00 0.00 H ATOM 9155 P CYT 17 5.701-17. 620 51.536 1.00 0. 00 P ATOM 9156 O1P CYT 17 6.263-18. 987 51.612 1.00 0.00 0 ATOM 9157 02P CYT 17 4.528-17. 258 52.365 1.00 0.00 O ATOM 9158 05'CYT 17 5.351-17. 303 49.997 1.00 0. 00 O ATOM 9159 C5'CYT 17 4.664-16. 100 49.646 1.00 0. 00 C

ATOM 9160 C4'CYT 17 4.408-16. 005 48.147 1.00 0.00 C ATOM 9161 04'CYT 17 5.636-15. 925 47.411 1.00 0.00 O ATOM 9162 C1'CYT 17 5.607-16. 885 46.356 1.00 0.00 C ATOM 9163 N1 CYT 17 6.967-17. 328 45.993 1.00 0.00 N ATOM 9164 C6 CYT 17 7.945-17. 397 46.933 1.00 0.00 C ATOM 9165 C2 CYT 17 7. 209-17. 660 44.666 1.00 0.00 C ATOM 9166 02 CYT 17 6.306-17. 587 43.833 1.00 0.00 O ATOM 9167 N3 CYT 17 8.464-18. 060 44.322 1.00 0.00 N ATOM 9168 C4 CYT 17 9.438-18. 132 45.238 1.00 0.00 C ATOM 9169 N4 CYT 17 10.657-18. 525 44.869 1.00 0.00 N ATOM 9170 C5 CYT 17 9.186-17. 791 46.604 1.00 0.00 C ATOM 9171 C2'CYT 17 4.769-18. 022 46.906 1.00 0.00 C ATOM 9172 02'CYT 17 4.232-18. 842 45.861 1.00 0.00 0 ATOM 9173 C3'CYT 17 3.681-17. 250 47.639 1.00 0.00 C ATOM 9174 03'CYT 17 2.697-16. 837 46.682 1.00 0.00 O ATOM 9175 1H5'CYT 17 5.259-15. 247 49.956 1.00 0.00 H ATOM 9176 2H5'CYT 17 3.712-16. 075 50.168 1.00 0.00 H ATOM 9177 H4'CYT 17 3.806-15. 122 47.937 1.00 0.00 H ATOM 9178 Hl'CYT 17 5.117-16. 458 45.488 1.00 0.00 H ATOM 9179 H6 CYT 17 7.722-17. 121 47.962 1.00 0.00 H ATOM 9180 1H4 CYT 17 11.399-18. 581 45.553 1.00 0.00 H ATOM 9181 2H4 CYT 17 10.840-18. 766 43.905 1.00 0.00 H ATOM 9182 H5 CYT 17 9.970-17. 851 47.354 1.00 0.00 H ATOM 9183 H2'CYT 17 5.354-18. 614 47.617 1.00 0.00 H ATOM 9184 H02'CYT 17 3.623-19. 462 46.269 1.00 0.00 H ATOM 9185 H3'CYT 17 3.248-17. 825 48.457 1.00 0.00 H ATOM 9186 P GUA 18 1.147-16. 695 47.104 1.00 0.00 P ATOM 9187 O1P GUA 18 0.768-17. 895 47.883 1.00 0.00 0 ATOM 9188 02P GUA 18 0.372-16. 324 45.899 1.00 0.00 O ATOM 9189 05'GUA 18 1.165-15. 431 48.103 1.00 0.00 O ATOM 9190 C5'GUA 18 1.339-14. 103 47.599 1.00 0.00 C ATOM 9191 C4'GUA 18 1.545-13. 097 48.729 1.00 0.00 C ATOM 9192 04'GUA 18 2.705-13. 410 49.497 1.00 0.00 0 ATOM 9193 Cl'GUA 18 3.340-12. 196 49.935 1.00 0.00 C ATOM 9194 N9 GUA 18 4.760-12. 165 49.531 1.00 0.00 N ATOM 9195 C4 GUA 18 5.289-12. 584 48.328 1.00 0.00 C ATOM 9196 N3 GUA 18 4.590-13. 073 47.279 1.00 0.00 N ATOM 9197 C2 GUA 18 5.381-13. 398 46.251 1.00 0.00 C ATOM 9198 N2 GUA 18 4.852-13. 900 45.136 1.00 0.00 N ATOM 9199 N1 GUA 18 6.754-13. 248 46.264 1.00 0.00 N ATOM 9200 C6 GUA 18 7.494-12. 748 47.328 1.00 0.00 C ATOM 9201 06 GUA 18 8.717-12. 657 47.241 1.00 0.00 O ATOM 9202 C5 GUA 18 6.661-12. 401 48.424 1.00 0.00 C ATOM 9203 N7 GUA 18 7.001-11. 870 49.671 1.00 0.00 N ATOM 9204 C8 GUA 18 5.847-11. 767 50.237 1.00 0.00 C ATOM 9205 C2'GUA 18 2.554-11. 034 49.320 1.00 0.00 C ATOM 9206 02'GUA 18 1.660-10. 449 50.275 1.00 0.00 0 ATOM 9207 C3'GUA 18 1.797-11. 703 48.184 1.00 0.00 C ATOM 9208 03'GUA 18 0.531-11. 048 48. 026 1.00 0.00 0 ATOM 9209 1H5'GUA 18 0.454-13. 820 47.027 1.00 0.00 H ATOM 9210 2H5'GUA 18 2.208-14. 082 46.942 1.00 0.00 H ATOM 9211 H4'GUA 18 0. 671-13. 086 49.379 1.00 0.00 H ATOM 9212 H1'GUA 18 3.276-12. 133 51.022 1.00 0.00 H ATOM 9213 1H2 GUA 18 5. 449-14. 145 44.359 1.00 0.00 H ATOM 9214 2H2 GUA 18 3. 854-14. 036 45.068 1.00 0.00 H ATOM 9215 Hl GUA 18 7.283-13. 518 45.446 1.00 0.00 H ATOM 9216 H8 GUA 18 5.748-11. 373 51.248 1.00 0.00 H ATOM 9217 H2'GUA 18 3. 243-10. 283 48.921 1.00 0.00 H ATOM 9218 H02'GUA 18 2. 198-10. 018 50.943 1.00 0.00 H

ATOM 9219 H3'GUA 18 2.378-11. 721 47.261 1.00 0.00 H ATOM 9220 P GUA 19 0.431-9. 613 47.302 1.00 0.00 P ATOM 9221 O1P GUA 19 1. 145-8. 620 48.137 1.00 0.00 0 ATOM 9222 02P GUA 19-0.982-9. 382 46.928 1.00 0.00 0 ATOM 9223 05'GUA 19 1.276-9. 855 45.951 1.00 0.00 0 ATOM 9224 C5'GUA 19 2.159-8. 853 45.434 1.00 0. 00 C ATOM 9225 C4'GUA 19 3.297-8. 537 46.404 1.00 0.00 C ATOM 9226 04'GUA 19 3.968-9. 731 46.840 1.00 0.00 0 ATOM 9227 Cl'GUA 19 5.376-9. 608 46.585 1.00 0.00 C ATOM 9228 N9 GUA 19 5.750-10. 320 45.347 1.00 0.00 N ATOM 9229 C4 GUA 19 7.025-10. 553 44.882 1.00 0.00 C ATOM 9230 N3 GUA 19 8.173-10. 165 45.481 1.00 0.00 N ATOM 9231 C2 GUA 19 9.254-10. 537 44.789 1.00 0.00 C ATOM 9232 N2 GUA 19 10.470-10. 232 45.239 1.00 0.00 N ATOM 9233 N1 GUA 19 9.199-11. 236 43.600 1.00 0.00 N ATOM 9234 C6 GUA 19 8.033-11. 644 42.966 1.00 0.00 C ATOM 9235 06 GUA 19 8.091-12. 264 41.907 1.00 0.00 0 ATOM 9236 C5 GUA 19 6.880-11. 253 43.694 1.00 0.00 C ATOM 9237 N7 GUA 19 5.528-11. 463 43.407 1.00 0.00 N ATOM 9238 C8 GUA 19 4.956-10. 892 44.411 1.00 0.00 C ATOM 9239 C2'GUA 19 5.623-8. 116 46.457 1.00 0.00 C ATOM 9240 02'GUA 19 5.735-7. 487 47.740 1.00 0.00 0 ATOM 9241 C3'GUA 19 4.367-7. 688 45.728 1.00 0.00 C ATOM 9242 03'GUA 19 4.112-6. 310 46.016 1.00 0.00 0 ATOM 9243 1H5'GUA 19 1.591-7. 942 45.243 1.00 0.00 H ATOM 9244 2H5'GUA 19 2.582-9. 209 44.495 1.00 0.00 H ATOM 9245 H4'GUA 19 2.904-8. 007 47.271 1.00 0.00 H ATOM 9246 H1'GUA 19 5.941-10. 006 47.427 1.00 0.00 H ATOM 9247 1H2 GUA 19 10.575-9. 720 46.103 1.00 0.00 H ATOM 9248 2H2 GUA 19 11.288-10. 513 44.717 1.00 0.00 H ATOM 9249 Hl GUA 19 10. 062-11. 482 43.137 1.00 0.00 H ATOM 9250 H8 GUA 19 3.871-10. 868 44.504 1.00 0.00 H ATOM 9251 H2'GUA 19 6.509-7. 927 45.843 1.00 0.00 H ATOM 9252 H02'GUA 19 4.921-7. 667 48.217 1.00 0.00 H ATOM 9253 H3'GUA 19 4.431-7. 891 44.658 1.00 0.00 H ATOM 9254 P ADE 20 4.553-5. 163 44.976 1.00 0.00 P ATOM 9255 01P ADE 20 3.992-5. 501 43.649 1.00 0.00 0 ATOM 9256 02P ADE 20 4.258-3. 847 45.587 1.00 0.00 0 ATOM 9257 05'ADE 20 6.152-5. 345 44.910 1.00 0.00 0 ATOM 9258 C5'ADE 20 6.983-4. 874 45.975 1.00 0.00 C ATOM 9259 C4'ADE 20 8.456-5. 185 45.723 1.00 0.00 C ATOM 9260 04'ADE 20 8.693-6. 594 45.619 1.00 0.00 0 ATOM 9261 C1'ADE 20 9.674-6. 839 44.590 1.00 0.00 C ATOM 9262 N9 ADE 20 9.097-7. 604 43.467 1.00 0.00 N ATOM 9263 C4 ADE 20 9.793-8. 273 42.484 1.00 0.00 C ATOM 9264 N3 ADE 20 11.133-8. 345 42.363 1.00 0.00 N ATOM 9265 C2 ADE 20 11.485-9. 069 41.306 1.00 0.00 C ATOM 9266 N1 ADE 20 10.673-9. 673 40.437 1.00 0.00 N ATOM 9267 C6 ADE 20 9.339-9. 588 40.579 1.00 0.00 C ATOM 9268 N6 ADE 20 8.547-10. 212 39.707 1.00 0.00 N ATOM 9269 C5 ADE 20 8.852-8. 846 41.661 1.00 0.00 C ATOM 9270 N7 ADE 20 7.559-8. 551 42.103 1.00 0.00 N ATOM 9271 C8 ADE 20 7.799-7. 831 43.147 1.00 0.00 C ATOM 9272 C2'ADE 20 10.149-5. 466 44.124 1.00 0.00 C ATOM 9273 02'ADE 20 11.280-5. 016 44.882 1.00 0.00 0 ATOM 9274 C3'ADE 20 8.922-4. 621 44.393 1.00 0.00 C ATOM 9275 03'ADE 20 9.328-3. 263 44.581 1.00 0.00 0 ATOM 9276 1H5'ADE 20 6.674-5. 349 46.906 1.00 0.00 H ATOM 9277 2H5'ADE 20 6.860-3. 795 46.070 1.00 0.00 H

ATOM 9278 H4'ADE 20 9.063-4. 776 46.529 1.00 0.00 H ATOM 9279 H1'ADE 20 10.514-7. 390 45.013 1.00 0.00 H ATOM 9280 H2 ADE 20 12.555-9. 180 41.128 1.00 0.00 H ATOM 9281 1H6 ADE 20 7.544-10. 162 39.811 1.00 0.00 H ATOM 9282 2H6 ADE 20 8.951-10. 740 38.946 1.00 0.00 H ATOM 9283 H8 ADE 20 6.989-7. 417 43.746 1.00 0.00 H ATOM 9284 H2'ADE 20 10.373-5. 485 43.055 1.00 0.00 H ATOM 9285 H02'ADE 20 12.045-5. 504 44.569 1.00 0.00 H ATOM 9286 H3'ADE 20 8.169-4. 733 43.611 1.00 0.00 H ATOM 9287 P GUA 21 9.515-2. 287 43.313 1.00 0.00 P ATOM 9288 01P GUA 21 8.328-2. 428 42.441 1. 00 0.00 O ATOM 9289 02P GUA 21 9.909-0. 950 43.812 1.00 0.00 O ATOM 9290 05'GUA 21 10.778-2. 937 42.553 1.00 0.00 O ATOM 9291 C5'GUA 21 12.110-2. 685 43.011 1.00 0.00 C ATOM 9292 C4'GUA 21 13.153-3. 237 42.044 1.00 0.00 C ATOM 9293 04'GUA 21 13.088-4. 663 41.939 1.00 0.00 O ATOM 9294 Cl'GUA 21 13.348-5. 053 40.575 1.00 0.00 C ATOM 9295 N9 GUA 21 12.178-5. 729 39.980 1.00 0.00 N ATOM 9296 C4 GUA 21 12.192-6. 625 38.933 1. 00 0.00 C ATOM 9297 N3 GUA 21 13.285-7. 019 38.240 1.00 0.00 N ATOM 9298 C2 GUA 21 12.984-7. 898 37.280 1.00 0.00 C ATOM 9299 N2 GUA 21 13.945-8. 379 36.491 1.00 0. 00 N ATOM 9300 N1 GUA 21 11.705-8. 352 37.031 1.00 0.00 N ATOM 9301 C6 GUA 21 10.569-7. 965 37. 728 1.00 0.00 C ATOM 9302 06 GUA 21 9.475-8. 440 37.435 1.00 0.00 O ATOM 9303 C5 GUA 21 10.878-7. 027 38.748 1.00 0.00 C ATOM 9304 N7 GUA 21 10.035-6. 390 39.664 1.00 0.00 N ATOM 9305 C8 GUA 21 10.870-5. 664 40.329 1.00 0.00 C ATOM 9306 C2'GUA 21 13.683-3. 766 39.824 1.00 0.00 C ATOM 9307 02'GUA 21 15.091-3. 501 39.835 1.00 0.00 O ATOM 9308 C3'GUA 21 12.914-2. 742 40.631 1. 00 0.00 C ATOM 9309 03'GUA 21 13.536-1. 462 40.479 1.00 0.00 0 ATOM 9310 1H5'GUA 21 12.246-3. 152 43.987 1.00 0.00 H ATOM 9311 2H5'GUA 21 12.253-1. 608 43.109 1.00 0.00 H ATOM 9312 H4'GUA 21 14.150-2. 945 42.371 1.00 0.00 H ATOM 9313 H1'GUA 21 14.208-5. 724 40.547 1. 00 0.00 H ATOM 9314 1H2 GUA 21 14.901-8. 079 36.620 1.00 0.00 H ATOM 9315 2H2 GUA 21 13.717-9. 039 35.761 1.00 0.00 H ATOM 9316 H1 GUA 21 11.561-9. 020 36.288 1.00 0.00 H ATOM 9317 H8 GUA 21 10.533-5. 012 41.133 1.00 0.00 H ATOM 9318 H2'GUA 21 13.299-3. 815 38.804 1.00 0.00 H ATOM 9319 H02'GUA 21 15.481-4. 000 39.113 1.00 0.00 H ATOM 9320 H3'GUA 21 11.853-2. 730 40.373 1.00 0.00 H ATOM 9321 P ADE 22 13.061-0. 456 39.313 1.00 0.00 P ATOM 9322 01P ADE 22 13.619 0.884 39.602 1.00 0.00 0 ATOM 9323 02P ADE 22 11.602-0. 622 39.122 1.00 0.00 O ATOM 9324 05'ADE 22 13.809-1. 046 38.015 1.00 0.00 O ATOM 9325 C5'ADE 22 15.227-0. 921 37.876 1.00 0.00 C ATOM 9326 C4'ADE 22 15.777-1. 867 36.812 1.00 0.00 C ATOM 9327 04'ADE 22 15.437-3. 231 37.092 1.00 0.00 O ATOM 9328 C1'ADE 22 15.069-3. 894 35.866 1.00 0.00 C ATOM 9329 N9 ADE 22 13.637-4. 252 35.854 1.00 0.00 N ATOM 9330 C4 ADE 22 13.058-5. 277 35.144 1.00 0.00 C ATOM 9331 N3 ADE 22 13.693-6. 141 34.328 1.00 0.00 N ATOM 9332 C2 ADE 22 12.845-7. 012 33.793 1.00 0.00 C ATOM 9333 N1 ADE 22 11.528-7. 082 33.992 1.00 0.00 N ATOM 9334 C6 ADE 22 10.917-6. 207 34.811 1.00 0.00 C ATOM 9335 N6 ADE 22 9.601-6. 293 34.999 1.00 0.00 N ATOM 9336 C5 ADE 22 11.714-5. 241 35.431 1.00 0.00 C ATOM 9337 N7 ADE 22 11.423-4. 202 36.320 1.00 0. 00 N

ATOM 9338 C8 ADE 22 12.590-3. 687 36.507 1.00 0. 00 C ATOM 9339 C2'ADE 22 15.394-2. 912 34.748 1.00 0.00 C ATOM 9340 02'ADE 22 16.748-3. 055 34.304 1.00 0. 00 0 ATOM 9341 C3'ADE 22 15.170-1. 589 35.447 1.00 0.00 C ATOM 9342 03'ADE 22 15.947-0. 582 34.790 1.00 0.00 0 ATOM 9343 1H5'ADE 22 15.699-1. 150 38.831 1.00 0.00 H ATOM 9344 2H5'ADE 22 15.467 0.105 37.598 1.00 0.00 H ATOM 9345 H4'ADE 22 16.860-1. 770 36.759 1.00 0.00 H ATOM 9346 H1'ADE 22 15.671-4. 794 35.746 1.00 0.00 H ATOM 9347 H2 ADE 22 13.273-7. 749 33.113 1.00 0.00 H ATOM 9348 1H6 ADE 22 9.136-5. 641 35.613 1.00 0.00 H ATOM 9349 2H6 ADE 22 9.068-7. 011 34.527 1.00 0.00 H ATOM 9350 H8 ADE 22 12.730-2. 829 37.165 1.00 0.00 H ATOM 9351 H2'ADE 22 14.690-3. 033 33.919 1.00 0.00 H ATOM 9352 H02'ADE 22 17.312-2. 970 35.075 1.00 0.00 H ATOM 9353 H3'ADE 22 14.110-1. 333 35.509 1.00 0.00 H ATOM 9354 P CYT 23 15.412 0.116 33.439 1.00 0.00 P ATOM 9355 O1P CYT 23 16.382 1.160 33.041 1.00 0.00 0 ATOM 9356 02P CYT 23 13.987 0.468 33.632 1.00 0.00 0 ATOM 9357 05'CYT 23 15.491-1. 083 32.365 1.00 0.00 0 ATOM 9358 C5'CYT 23 16.756-1. 601 31.943 1.00 0.00 C ATOM 9359 C4'CYT 23 16.594-2. 811 31.025 1.00 0.00 C ATOM 9360 04'CYT 23 15.842-3. 852 31.645 1.00 0.00 0 ATOM 9361 C1'CYT 23 15.103-4. 570 30.638 1.00 0. 00 C ATOM 9362 N1 CYT 23 13.663-4. 636 30.971 1.00 0.00 N ATOM 9363 C6 CYT 23 13.035-3. 597 31.596 1.00 0.00 C ATOM 9364 C2 CYT 23 12.976-5. 794 30.625 1.00 0.00 C ATOM 9365 02 CYT 23 13.562-6. 716 30.060 1.00 0. 00 0 ATOM 9366 N3 CYT 23 11.652-5. 873 30. 925 1.00 0.00 N ATOM 9367 C4 CYT 23 11.023-4. 863 31.538 1.00 0.00 C ATOM 9368 N4 CYT 23 9.725-4. 977 31.817 1.00 0. 00 N ATOM 9369 C5 CYT 23 11.724-3. 668 31.896 1.00 0.00 C ATOM 9370 C2'CYT 23 15.332-3. 828 29.315 1.00 0.00 C ATOM 9371 02'CYT 23 16.327-4. 479 28.517 1.00 0.00 0 ATOM 9372 C3'CYT 23 15.799-2. 460 29.785 1.00 0.00 C ATOM 9373 03'CYT 23 16.700-1. 916 28.813 1.00 0.00 0 ATOM 9374 1H5'CYT 23 17.331-1. 896 32.821 1.00 0.00 H ATOM 9375 2H5'CYT 23 17.298-0. 820 31.408 1.00 0.00 H ATOM 9376 H4'CYT 23 17.574-3. 192 30.740 1.00 0.00 H ATOM 9377 H1'CYT 23 15.501-5. 582 30.555 1.00 0.00 H ATOM 9378 H6 CYT 23 13.600-2. 701 31.855 1.00 0.00 H ATOM 9379 1H4 CYT 23 9.240-4. 223 32.280 1.00 0.00 H ATOM 9380 2H4 CYT 23 9.227-5. 819 31.564 1.00 0.00 H ATOM 9381 H5 CYT 23 11.214-2. 843 32.393 1.00 0.00 H ATOM 9382 H2'CYT 23 14.390-3. 738 28. 767 1.00 0.00 H ATOM 9383 H02'CYT 23 16.476-3. 930 27.745 1.00 0.00 H ATOM 9384 H3'CYT 23 14.963-1. 795 30.005 1.00 0. 00 H ATOM 9385 P GUA 24 16.148-1. 063 27.563 1. 00 0.00 P ATOM 9386 01P GUA 24 17.243-0. 192 27.079 1.00 0. 00 0 ATOM 9387 02P GUA 24 14.846-0. 468 27.941 1.00 0.00 0 ATOM 9388 05'GUA 24 15. 880-2. 199 26.456 1.00 0.00 0 ATOM 9389 C5'GUA 24 16.969-2. 811 25.758 1.00 0.00 C ATOM 9390 C4'GUA 24 16.501-3. 469 24. 464 1.00 0. 00 C ATOM 9391 04'GUA 24 15.494-4. 464 24.714 1. 00 0.00 0 ATOM 9392 Cl'GUA 24 14.372-4. 237 23.844 1.00 0. 00 C ATOM 9393 N9 GUA 24 13.252-3. 602 24.563 1.00 0.00 N ATOM 9394 C4 GUA 24 11.986-3. 403 24. 074 1.00 0. 00 C ATOM 9395 N3 GUA 24 11.547-3. 772 22.851 1. 00 0. 00 N ATOM 9396 C2 GUA 24 10.270-3. 447 22.655 1.00 0.00 C ATOM 9397 N2 GUA 24 9.679-3. 747 21. 500 1.00 0.00 N

ATOM 9398 N1 GUA 24 9.491-2. 807 23.598 1.00 0.00 N ATOM 9399 C6 GUA 24 9.917-2. 418 24.860 1.00 0.00 C ATOM 9400 06 GUA 24 9.143-1. 849 25.626 1.00 0.00 0 ATOM 9401 C5 GUA 24 11.277-2. 761 25.077 1.00 0.00 C ATOM 9402 N7 GUA 24 12.088-2. 555 26.197 1.00 0.00 N ATOM 9403 C8 GUA 24 13.205-3. 071 25.810 1.00 0.00 C ATOM 9404 C2'GUA 24 14.897-3. 326 22.746 1.00 0.00 C ATOM 9405 02'GUA 24 15.584-4. 065 21.728 1.00 0.00 0 ATOM 9406 C3'GUA 24 15.841-2. 452 23.542 1.00 0.00 C ATOM 9407 03'GUA 24 16.832-1. 915 22.661 1.00 0.00 O ATOM 9408 1H5'GUA 24 17.424-3. 567 26.397 1.00 0.00 H ATOM 9409 2H5'GUA 24 17.713-2. 050 25.520 1.00 0.00 H ATOM 9410 H4'GUA 24 17.347-3. 930 23.958 1.00 0.00 H ATOM 9411 H1'GUA 24 14.039-5. 181 23.411 1.00 0.00 H ATOM 9412 1H2 GUA 24 10.199-4. 219 20.775 1.00 0.00 H ATOM 9413 2H2 GUA 24 8.712-3. 503 21.350 1.00 0.00 H ATOM 9414 H1 GUA 24 8.533-2. 596 23.373 1.00 0.00 H ATOM 9415 H8 GUA 24 14.079-3. 081 26.462 1.00 0.00 H ATOM 9416 H2'GUA 24 14.083-2. 730 22.324 1.00 0.00 H ATOM 9417 H02'GUA 24 14.921-4. 556 21.236 1.00 0.00 H ATOM 9418 H3'GUA 24 15.308-1. 679 24.098 1.00 0.00 H ATOM 9419 P ADE 25 16.628-0. 463 21.994 1.00 0.00 P ATOM 9420 01P ADE 25 17. 842-0. 136 21.214 1.00 0.00 O ATOM 9421 02P ADE 25 16.153 0.466 23.044 1.00 0.00 0 ATOM 9422 05'ADE 25 15.418-0. 719 20.963 1.00 0.00 0 ATOM 9423 C5'ADE 25 15. 581-1. 622 19.865 1.00 0.00 C ATOM 9424 C4'ADE 25 14.244-1. 979 19.220 1.00 0.00 C ATOM 9425 04'ADE 25 13.316-2. 508 20.175 1.00 0.00 0 ATOM 9426 C1'ADE 25 11.993-2. 021 19.873 1.00 0.00 C ATOM 9427 N9 ADE 25 11.475-1. 154 20.951 1.00 0.00 N ATOM 9428 C4 ADE 25 10.206-0. 629 21.041 1.00 0.00 C ATOM 9429 N3 ADE 25 9.203-0. 810 20.160 1.00 0.00 N ATOM 9430 C2 ADE 25 8.104-0. 167 20.539 1.00 0.00 C ATOM 9431 N1 ADE 25 7.943 0.578 21.635 1.00 0.00 N ATOM 9432 C6 ADE 25 8.959 0.743 22.499 1.00 0.00 C ATOM 9433 N6 ADE 25 8.777 1.488 23.588 1.00 0.00 N ATOM 9434 C5 ADE 25 10.170 0.109 22.200 1.00 0.00 C ATOM 9435 N7 ADE 25 11.404 0.065 22.857 1.00 0.00 N ATOM 9436 C8 ADE 25 12. 093-0.685 22.064 1.00 0.00 C ATOM 9437 C2'ADE 25 12.119-1. 244 18.567 1.00 0.00 C ATOM 9438 02'ADE 25 11.916-2. 093 17.430 1.00 0.00 O ATOM 9439 C3'ADE 25 13.549-0. 755 18.653 1.00 0.00 C ATOM 9440 03'ADE 25 14.037-0. 516 17.330 1.00 0.00 O ATOM 9441 1H5'ADE 25 16.056-2. 535 20.224 1.00 0.00 H ATOM 9442 2H5'ADE 25 16.223-1. 158 19.116 1.00 0.00 H ATOM 9443 H4'ADE 25 14.401-2. 711 18.429 1.00 0.00 H ATOM 9444 H1'ADE 25 11.319-2. 865 19.729 1.00 0.00 H ATOM 9445 H2 ADE 25 7.237-0. 259 19.884 1.00 0.00 H ATOM 9446 1H6 ADE 25 9.534 1.617 24.245 1.00 0.00 H ATOM 9447 2H6 ADE 25 7.881 1.923 23.758 1.00 0.00 H ATOM 9448 H8 ADE 25 13.133-0. 928 22.279 1.00 0.00 H ATOM 9449 H2'ADE 25 11.425-0. 399 18.558 1.00 0.00 H ATOM 9450 H02'ADE 25 12.533-2. 825 17.507 1.00 0.00 H ATOM 9451 H3'ADE 25 13.644 0. 115 19.304 1.00 0.00 H ATOM 9452 P CYT 26 13.729 0.880 16.589 1.00 0.00 P ATOM 9453 O1P CYT 26 14.088 1.983 17.509 1.00 0.00 0 ATOM 9454 02P CYT 26 14. 322 0.827 15.234 1.00 0.00 O ATOM 9455 05'CYT 26 12.127 0.850 16.442 1.00 0.00 O ATOM 9456 C5'CYT 26 11.496-0. 028 15.506 1.00 0. 00 C ATOM 9457 C4'CYT 26 9.997 0.239 15.411 1.00 0. 00 C

ATOM 9458 04'CYT 26 9.323-0. 034 16.649 1.00 0.00 0 ATOM 9459 C1'CYT 26 8.392 1.030 16.932 1.00 0.00 C ATOM 9460 N1 CYT 26 8.855 1.858 18.066 1.00 0.00 N ATOM 9461 C6 CYT 26 10.186 2.063 18.283 1.00 0.00 C ATOM 9462 C2 CYT 26 7.891 2.424 18. 892 1.00 0.00 C ATOM 9463 02 CYT 26 6.696 2.225 18.678 1.00 0.00 O ATOM 9464 N3 CYT 26 8.308 3.197 19.933 1.00 0.00 N ATOM 9465 C4 CYT 26 9. 612 3.406 20. 154 1.00 0.00 C ATOM 9466 N4 CYT 26 9.987 4. 162 21.186 1.00 0.00 N ATOM 9467 C5 CYT 26 10.605 2.826 19. 304 1.00 0.00 C ATOM 9468 C2'CYT 26 8.310 1.853 15.653 1.00 0.00 C ATOM 9469 02'CYT 26 7.346 1.316 14.738 1.00 0.00 O ATOM 9470 C3'CYT 26 9.724 1.706 15.132 1.00 0.00 C ATOM 9471 03'CYT 26 9.729 1.909 13.717 1.00 0.00 0 ATOM 9472 1H5'CYT 26 11.655-1. 060 15. 820 1.00 0.00 H ATOM 9473 2H5'CYT 26 11.945 0.118 14.524 1.00 0.00 H ATOM 9474 H4'CYT 26 9.563-0. 372 14. 621 1.00 0.00 H ATOM 9475 H1'CYT 26 7.413 0.609 17.159 1.00 0.00 H ATOM 9476 H6 CYT 26 10.919 1.598 17.624 1.00 0.00 H ATOM 9477 1H4 CYT 26 10.968 4.323 21.364 1.00 0.00 H ATOM 9478 2H4 CYT 26 9.291 4.575 21. 789 1.00 0.00 H ATOM 9479 H5 CYT 26 11. 663 3.007 19.467 1.00 0.00 H ATOM 9480 H2'CYT 26 8.094 2.898 15.888 1.00 0.00 H ATOM 9481 H02'CYT 26 6.487 1.376 15. 162 1.00 0.00 H ATOM 9482 H3'CYT 26 10.422 2. 362 15.658 1.00 0.00 H ATOM 9483 P CYT 27 10. 476 3.185 13.080 1.00 0.00 P ATOM 9484 01P CYT 27 11.735 3.407 13.826 1.00 0.00 O ATOM 9485 02P CYT 27 10.508 3.018 11.610 1.00 0.00 O ATOM 9486 05'CYT 27 9.464 4.385 13.431 1.00 0.00 O ATOM 9487 C5'CYT 27 8.114 4.350 12.960 1.00 0.00 C ATOM 9488 C4'CYT 27 7.183 5.156 13.860 1.00 0.00 C ATOM 9489 04'CYT 27 7.241 4.719 15.217 1.00 0.00 O ATOM 9490 C1'CYT 27 6.957 5.841 16.078 1.00 0.00 C ATOM 9491 N1 CYT 27 8.008 6.031 17.104 1.00 0.00 N ATOM 9492 C6 CYT 27 9.281 5.570 16.917 1.00 0.00 C ATOM 9493 C2 CYT 27 7.650 6.717 18.256 1.00 0.00 C ATOM 9494 02 CYT 27 6.500 7.126 18.398 1.00 0.00 0 ATOM 9495 N3 CYT 27 8.598 6.926 19.206 1.00 0.00 N ATOM 9496 C4 CYT 27 9.849 6.484 19.039 1.00 0.00 C ATOM 9497 N4 CYT 27 10.750 6.706 19.995 1.00 0.00 N ATOM 9498 C5 CYT 27 10. 229 5.776 17.855 1.00 0.00 C ATOM 9499 C2'CYT 27 6.855 7.071 15.171 1.00 0.00 C ATOM 9500 02'CYT 27 5.490 7.397 14.884 1.00 0.00 O ATOM 9501 C3'CYT 27 7.594 6.610 13.928 1.00 0.00 C ATOM 9502 03'CYT 27 7.062 7.297 12.790 1.00 0.00 O ATOM 9503 1H5'CYT 27 7.773 3.315 12.934 1.00 0.00 H ATOM 9504 2H5'CYT 27 8.078 4.762 11.952 1.00 0.00 H ATOM 9505 H4'CYT 27 6.159 5.077 13.498 1.00 0.00 H ATOM 9506 Hl'CYT 27 5.997 5.679 16.571 1.00 0.00 H ATOM 9507 H6 CYT 27 9.530 5.024 16.006 1.00 0.00 H ATOM 9508 1H4 CYT 27 11.698 6.376 19. 882 1.00 0.00 H ATOM 9509 2H4 CYT 27 10.482 7.200 20.834 1.00 0.00 H ATOM 9510 H5 CYT 27 11.253 5.426 17.713 1.00 0. 00 H ATOM 9511 H2'CYT 27 7.374 7.918 15.626 1.00 0. 00 H ATOM 9512 H02'CYT 27 5.113 7.775 15.682 1.00 0.00 H ATOM 9513 H3'CYT 27 8.674 6.729 14.026 1.00 0.00 H ATOM 9514 P GUA 28 7.505 8.812 12.471 1.00 0.00 P ATOM 9515 O1P GUA 28 7.006 9.167 11.124 1.00 0.00 0 ATOM 9516 02P GUA 28 8.946 8.949 12.783 1.00 0. 00 O ATOM 9517 05'GUA 28 6.672 9.658 13.560 1.00 0.00 O

ATOM 9518 C5'GUA 28 5.319 10.047 13.301 1.00 0.00 C ATOM 9519 C4'GUA 28 4.809 11.033 14.347 1.00 0.00 C ATOM 9520 04'GUA 28 4.741 10.441 15. 648 1.00 0.00 0 ATOM 9521 Cl'GUA 28 5.174 11.396 16.636 1.00 0.00 C ATOM 9522 N9 GUA 28 6.401 10.936 17.316 1.00 0.00 N ATOM 9523 C4 GUA 28 6.713 11.102 18.647 1.00 0.00 C ATOM 9524 N3 GUA 28 5.950 11.736 19.566 1.00 0.00 N ATOM 9525 C2 GUA 28 6.515 11.740 20.776 1.00 0.00 C ATOM 9526 N2 GUA 28 5.894 12.327 21.798 1.00 0.00 N ATOM 9527 N1 GUA 28 7.737 11.161 21.052 1.00 0.00 N ATOM 9528 C6 GUA 28 8.539 10.505 20. 127 1.00 0.00 C ATOM 9529 06 GUA 28 9.610 10.016 20.476 1.00 0.00 O ATOM 9530 C5 GUA 28 7.946 10.497 18.836 1.00 0.00 C ATOM 9531 N7 GUA 28 8.415 9.951 17.638 1.00 0.00 N ATOM 9532 C8 GUA 28 7. 462 10. 252 16.821 1.00 0.00 C ATOM 9533 C2'GUA 28 5.411 12. 707 15.889 1.00 0.00 C ATOM 9534 02'GUA 28 4.234 13.525 15.877 1.00 0.00 O ATOM 9535 C3'GUA 28 5.758 12.208 14.501 1.00 0.00 C ATOM 9536 03'GUA 28 5.403 13.209 13.543 1.00 0.00 0 ATOM 9537 1H5'GUA 28 4.685 9.160 13.307 1.00 0.00 H ATOM 9538 2H5'GUA 28 5.267 10.515 12.317 1.00 0.00 H ATOM 9539 H4'GUA 28 3.822 11.394 14.063 1.00 0.00 H ATOM 9540 H1'GUA 28 4. 382 11.537 17.373 1.00 0.00 H ATOM 9541 1H2 GUA 28 4.996 12.768 21.657 1.00 0.00 H ATOM 9542 2H2 GUA 28 6.323 12.336 22.712 1.00 0.00 H ATOM 9543 H1 GUA 28 8.098 11.210 21.994 1.00 0.00 H ATOM 9544 H8 GUA 28 7.511 9.972 15. 769 1.00 0.00 H ATOM 9545 H2'GUA 28 6.258 13.244 16.325 1.00 0.00 H ATOM 9546 H02'GUA 28 3.528 13.003 15.491 1.00 0.00 H ATOM 9547 H3'GUA 28 6.803 11.904 14. 427 1.00 0.00 H ATOM 9548 P CYT 29 6.544 13.974 12.704 1.00 0.00 P ATOM 9549 01P CYT 29 5.890 14.720 11.605 1.00 0.00 0 ATOM 9550 02P CYT 29 7.622 13.006 12.399 1.00 0.00 O ATOM 9551 05'CYT 29 7.110 15.036 13.773 1.00 0.00 0 ATOM 9552 C5'CYT 29 6.474 16.307 13.944 1.00 0.00 C ATOM 9553 C4'CYT 29 7.150 17.130 15.037 1.00 0.00 C ATOM 9554 04'CYT 29 7.049 16.497 16.317 1.00 0.00 0 ATOM 9555 C1'CYT 29 8.291 16.651 17.031 1.00 0.00 C ATOM 9556 N1 CYT 29 8.946 15.342 17.257 1.00 0.00 N ATOM 9557 C6 CYT 29 8.803 14.319 16.362 1.00 0.00 C ATOM 9558 C2 CYT 29 9.700 15.190 18.415 1.00 0.00 C ATOM 9559 02 CYT 29 9.819 16.125 19.205 1.00 0.00 0 ATOM 9560 N3 CYT 29 10.299 13.989 18.642 1.00 0.00 N ATOM 9561 C4 CYT 29 10.166 12.978 17.774 1.00 0.00 C ATOM 9562 N4 CYT 29 10.764 11.816 18.030 1.00 0.00 N ATOM 9563 C5 CYT 29 9.392 13.129 16.580 1.00 0.00 C ATOM 9564 C2'CYT 29 9.161 17.567 16.173 1.00 0.00 C ATOM 9565 02'CYT 29 8. 972 18.945 16.518 1.00 0.00 0 ATOM 9566 C3'CYT 29 8.641 17.263 14.783 1.00 0.00 C ATOM 9567 03'CYT 29 8.863 18.401 13.943 1.00 0.00 0 ATOM 9568 1H5'CYT 29 5.429 16.151 14.212 1.00 0.00 H ATOM 9569 2H5'CYT 29 6.523 16.856 13.004 1.00 0.00 H ATOM 9570 H4'CYT 29 6.697 18.119 15.086 1.00 0.00 H ATOM 9571 H1'CYT 29 8.098 17.132 17.991 1.00 0.00 H ATOM 9572 H6 CYT 29 8. 205 14.468 15.463 1.00 0. 00 H ATOM 9573 1H4 CYT 29 10.670 11.046 17.382 1.00 0.00 H ATOM 9574 2H4 CYT 29 11.311 11.703 18.872 1.00 0.00 H ATOM 9575 H5 CYT 29 9.284 12.308 15.871 1.00 0.00 H ATOM 9576 H2'CYT 29 10.212 17.280 16.259 1.00 0.00 H ATOM 9577 H02'CYT 29 9. 468 19.468 15.884 1.00 0.00 H

ATOM 9578 H3'CYT 29 9.073 16.347 14.376 1.00 0.00 H ATOM 9579 P CYT 30 10.081 18.418 12.888 1.00 0.00 P ATOM 9580 O1P CYT 30 9.848 19.521 11.929 1.00 0.00 0 ATOM 9581 02P CYT 30 10.286 17. 039 12.391 1.00 0.00 O ATOM 9582 05'CYT 30 11. 340 18.810 13.813 1.00 0.00 0 ATOM 9583 C5'CYT 30 11.449 20.121 14.378 1.00 0.00 C ATOM 9584 C4'CYT 30 12.272 20.112 15.662 1.00 0.00 C ATOM 9585 04'CYT 30 11.745 19.188 16.619 1.00 0.00 0 ATOM 9586 C1'CYT 30 12.831 18.553 17.315 1.00 0.00 C ATOM 9587 N1 CYT 30 12.856 17.093 17.066 1.00 0.00 N ATOM 9588 C6 CYT 30 12.553 16.580 15.835 1.00 0.00 C ATOM 9589 C2 CYT 30 13.210 16.268 18.125 1.00 0.00 C ATOM 9590 02 CYT 30 13.476 16.750 19.225 1.00 0.00 0 ATOM 9591 N3 CYT 30 13.253 14.925 17. 912 1.00 0.00 N ATOM 9592 C4 CYT 30 12.962 14.408 16.712 1.00 0.00 C ATOM 9593 N4 CYT 30 13.023 13.089 16.537 1.00 0.00 N ATOM 9594 C5 CYT 30 12.593 15.252 15. 617 1.00 0.00 C ATOM 9595 C2'CYT 30 14.106 19.223 16.805 1.00 0.00 C ATOM 9596 02'CYT 30 14.461 20.352 17.612 1.00 0.00 O ATOM 9597 C3'CYT 30 13.694 19.643 15.409 1.00 0.00 C ATOM 9598 03'CYT 30 14.521 20.696 14.899 1.00 0.00 O ATOM 9599 1H5'CYT 30 10.450 20.498 14.599 1.00 0.00 H ATOM 9600 2H5'CYT 30 11.925 20.781 13.653 1.00 0.00 H ATOM 9601 H4'CYT 30 12.287 21.111 16.096 1.00 0.00 H ATOM 9602 H1'CYT 30 12.731 18.737 18.385 1.00 0.00 H ATOM 9603 H6 CYT 30 12.273 17.251 15.024 1.00 0.00 H ATOM 9604 1H4 CYT 30 12. 809 12.688 15.635 1.00 0.00 H ATOM 9605 2H4 CYT 30 13.292 12.490 17.305 1.00 0.00 H ATOM 9606 H5 CYT 30 12.352 14.834 14. 639 1.00 0.00 H ATOM 9607 H2'CYT 30 14.924 18.498 16. 760 1.00 0. 00 H ATOM 9608 H02'CYT 30 13.699 20.934 17. 639 1.00 0.00 H ATOM 9609 H3'CYT 30 13.694 18.778 14.740 1.00 0.00 H ATOM 9610 H03'CYT 30 14.153 20. 965 14. 054 1.00 0.00 H TER ATOM 9611 05'GUA 1-8.678 26.114 7.719 1.00 0.00 0 ATOM 9612 C5'GUA 1-9.340 26.409 6.486 1.00 0.00 C ATOM 9613 C4'GUA 1-8.399 27.077 5.487 1.00 0.00 C ATOM 9614 04'GUA 1-7.863 28.305 6.008 1.00 0.00 O ATOM 9615 C1'GUA 1-6.435 28.317 5.835 1.00 0.00 C ATOM 9616 N9 GUA 1-5.740 28.047 7.111 1.00 0.00 N ATOM 9617 C4 GUA 1-4.414 28.291 7.396 1.00 0.00 C ATOM 9618 N3 GUA 1-3.506 28. 829 6.549 1.00 0.00 N ATOM 9619 C2 GUA 1-2. 298 28.941 7.110 1.00 0. 00 C ATOM 9620 N2 GUA 1-1. 283 29.446 6.410 1.00 0.00 N ATOM 9621 N1 GUA 1-2.016 28.553 8.405 1.00 0.00 N ATOM 9622 C6 GUA 1-2. 930 28.000 9.292 1.00 0.00 C ATOM 9623 06 GUA 1-2.576 27.687 10.427 1.00 0.00 0 ATOM 9624 C5 GUA 1-4. 216 27.876 8.704 1.00 0.00 C ATOM 9625 N7 GUA 1-5. 402 27.373 9.246 1.00 0.00 N ATOM 9626 C8 GUA 1-6.221 27.512 8.260 1.00 0.00 C ATOM 9627 C2'GUA 1-6.145 27.229 4. 815 1.00 0.00 C ATOM 9628 02'GUA 1-6.327 27.701 3.474 1.00 0.00 O ATOM 9629 C3'GUA 1-7.188 26.200 5.197 1.00 0. 00 C ATOM 9630 03'GUA 1-7. 472 25.384 4.056 1.00 0. 00 0 ATOM 9631 H5'GUA 1-7.989 25. 473 7.526 1.00 0.00 H ATOM 9632 1H5'GUA 1-10.180 27.076 6.685 1.00 0. 00 H ATOM 9633 2H5'GUA 1-9.717 25.482 6.055 1.00 0.00 H ATOM 9634 H4'GUA 1-8.933 27.282 4.560 1.00 0.00 H ATOM 9635 H1'GUA 1-6.121 29.284 5.442 1.00 0.00 H ATOM 9636 1H2 GUA 1-1.426 29.743 5.456 1.00 0. 00 H

ATOM 9637 2H2 GUA 1-0.369 29.529 6. 834 1.00 0.00 H ATOM 9638 H1 GUA 1-1.078 28.673 8.756 1.00 0.00 H ATOM 9639 H8 GUA 1-7.262 27.203 8.344 1.00 0.00 H ATOM 9640 H2'GUA 1-5.139 26.830 4.962 1.00 0.00 H ATOM 9641 H02'GUA 1-5.585 28.274 3.270 1.00 0.00 H ATOM 9642 H3'GUA 1-6.885 25.616 6.068 1.00 0.00 H ATOM 9643 P GUA 2-6.653 24.020 3.804 1.00 0.00 P ATOM 9644 O1P GUA 2-6.665 23.233 5.057 1.00 0.00 O ATOM 9645 02P GUA 2-7.142 23.412 2.546 1.00 0.00 0 ATOM 9646 05'GUA 2-5.153 24.552 3.558 1.00 0.00 0 ATOM 9647 C5'GUA 2-4.826 25.288 2.375 1.00 0.00 C ATOM 9648 C4'GUA 2-3.428 25.895 2.456 1.00 0.00 C ATOM 9649 04'GUA 2-3.293 26.769 3.582 1.00 0.00 0 ATOM 9650 C1'GUA 2-1.973 26.625 4.143 1.00 0.00 C ATOM 9651 N9 GUA 2-2.029 26.123 5.533 1.00 0.00 N ATOM 9652 C4 GUA 2-1.004 26.142 6.453 1.00 0.00 C ATOM 9653 N3 GUA 2 0.246 26.612 6.237 1.00 0.00 N ATOM 9654 C2 GUA 2 1.022 26.498 7.320 1.00 0.00 C ATOM 9655 N2 GUA 2 2.290 26.907 7.276 1.00 0.00 N ATOM 9656 N1 GUA 2 0.592 25.964 8.518 1.00 0.00 N ATOM 9657 C6 GUA 2-0.685 25.476 8.763 1.00 0.00 C ATOM 9658 06 GUA 2-0.970 25.024 9.869 1.00 0.00 0 ATOM 9659 C5 GUA 2-1.516 25.591 7.617 1.00 0.00 C ATOM 9660 N7 GUA 2-2.853 25. 222 7.441 1.00 0.00 N ATOM 9661 C8 GUA 2-3.061 25.565 6.214 1.00 0.00 C ATOM 9662 C2'GUA 2-1.229 25.646 3.237 1.00 0.00 C ATOM 9663 02'GUA 2-0.508 26.330 2.205 1.00 0.00 O ATOM 9664 C3'GUA 2-2.373 24.828 2.673 1.00 0.00 C ATOM 9665 03'GUA 2-1.982 24.300 1.401 1.00 0.00 0 ATOM 9666 1H5'GUA 2-5.554 26.089 2. 241 1.00 0.00 H ATOM 9667 2H5'GUA 2-4.873 24. 618 1.516 1.00 0.00 H ATOM 9668 H4'GUA 2-3.212 26.446 1.543 1.00 0.00 H ATOM 9669 Hl'GUA 2-1.466 27.590 4.126 1.00 0.00 H ATOM 9670 1H2 GUA 2 2.663 27.303 6.425 1.00 0.00 H ATOM 9671 2H2 GUA 2 2.877 26.820 8.093 1.00 0.00 H ATOM 9672 H1 GUA 2 1.239 25.916 9.291 1.00 0.00 H ATOM 9673 H8 GUA 2-4.031 25.408 5.744 1.00 0.00 H ATOM 9674 H2'GUA 2-0.564 25.015 3.829 1.00 0.00 H ATOM 9675 H02'GUA 2 0.256 26.742 2.616 1.00 0.00 H ATOM 9676 H3'GUA 2-2.704 24.054 3.368 1.00 0.00 H ATOM 9677 P CYT 3-1.206 22.892 1.305 1.00 0.00 P ATOM 9678 O1P CYT 3-1.055 22. 544-0. 126 1.00 0.00 O ATOM 9679 02P CYT 3-1.859 21.939 2. 230 1.00 0.00 O ATOM 9680 05'CYT 3 0.248 23.250 1.896 1.00 0.00 0 ATOM 9681 C5'CYT 3 1.232 23.892 1.079 1.00 0.00 C ATOM 9682 C4'CYT 3 2.552 24.073 1.824 1.00 0.00 C ATOM 9683 04'CYT 3 2.407 24.932 2.967 1.00 0.00 O ATOM 9684 C1'CYT 3 3.094 24.347 4.092 1.00 0.00 C ATOM 9685 N1 CYT 3 2.136 23.812 5.086 1.00 0.00 N ATOM 9686 C6 CYT 3 0.925 23.319 4.694 1.00 0.00 C ATOM 9687 C2 CYT 3 2.507 23.835 6.424 1.00 0.00 C ATOM 9688 02 CYT 3 3.609 24.272 6.755 1.00 0.00 O ATOM 9689 N3 CYT 3 1.627 23.356 7.346 1.00 0. 00 N ATOM 9690 C4 CYT 3 0.435 22. 872 6.972 1.00 0.00 C ATOM 9691 N4 CYT 3-0.407 22.420 7.899 1.00 0.00 N ATOM 9692 C5 CYT 3 0.052 22.843 5.596 1.00 0.00 C ATOM 9693 C2'CYT 3 3.953 23.236 3.507 1.00 0.00 C ATOM 9694 02'CYT 3 5.197 23.741 3.006 1.00 0.00 0 ATOM 9695 C3'CYT 3 3.054 22.754 2.390 1.00 0.00 C ATOM 9696 03'CYT 3 3.852 22. 096 1.403 1.00 0.00 O

ATOM 9697 1H5'CYT 3 0.859 24.869 0.772 1.00 0.00 H ATOM 9698 2H5'CYT 3 1.406 23.283 0.191 1.00 0. 00 H ATOM 9699 H4'CYT 3 3.300 24. 492 1.152 1.00 0.00 H ATOM 9700 Hl'CYT 3 3.732 25.097 4.562 1.00 0.00 H ATOM 9701 H6 CYT 3 0.663 23.312 3.637 1.00 0. 00 H ATOM 9702 1H4 CYT 3-1.311 22.059 7.628 1.00 0.00 H ATOM 9703 2H4 CYT 3-0.141 22.436 8.873 1.00 0. 00 H ATOM 9704 H5 CYT 3-0.912 22.441 5.286 1.00 0.00 H ATOM 9705 H2'CYT 3 4.112 22.446 4.244 1. 00 0. 00 H ATOM 9706 H02'CYT 3 5.487 23.145 2.311 1.00 0. 00 H ATOM 9707 H3'CYT 3 2.238 22.129 2.763 1.00 0.00 H ATOM 9708 P GUA 4 4.003 20. 492 1.417 1.00 0.00 P ATOM 9709 O1P GUA 4 4.894 20.102 0.302 1.00 0. 00 O ATOM 9710 02P GUA 4 2.651 19.899 1.523 1.00 0.00 O ATOM 9711 05'GUA 4 4.780 20.225 2.803 1.00 0.00 0 ATOM 9712 C5'GUA 4 6.142 20.634 2.962 1.00 0.00 C ATOM 9713 C4'GUA 4 6.555 20.662 4.432 1.00 0.00 C ATOM 9714 04'GUA 4 5.700 21.504 5.212 1.00 0.00 O ATOM 9715 C1'GUA 4 5.530 20.924 6.522 1.00 0. 00 C ATOM 9716 N9 GUA 4 4.115 20.596 6.791 1. 00 0.00 N ATOM 9717 C4 GUA 4 3.587 20.194 7.997 1.00 0.00 C ATOM 9718 N3 GUA 4 4.278 20.030 9.147 1.00 0.00 N ATOM 9719 C2 GUA 4 3.498 19. 629 10.154 1.00 0.00 C ATOM 9720 N2 GUA 4 4.026 19.417 11.358 1.00 0.00 N ATOM 9721 N1 GUA 4 2.139 19.408 10.029 1.00 0.00 N ATOM 9722 C6 GUA 4 1.407 19.570 8.859 1.00 0.00 C ATOM 9723 06 GUA 4 0.197 19.354 8.853 1.00 0.00 0 ATOM 9724 C5 GUA 4 2.232 19.996 7.783 1.00 0. 00 C ATOM 9725 N7 GUA 4 1.900 20.269 6.453 1.00 0.00 N ATOM 9726 C8 GUA 4 3.044 20.606 5.959 1.00 0.00 C ATOM 9727 C2'GUA 4 6.392 19.664 6.544 1.00 0.00 C ATOM 9728 02'GUA 4 7.705 19.935 7.049 1.00 0.00 0 ATOM 9729 C3'GUA 4 6.423 19.296 5.075 1.00 0.00 C ATOM 9730 03'GUA 4 7.611 18.543 4.810 1.00 0.00 0 ATOM 9731 1H5'GUA 4 6.266 21.631 2.540 1.00 0.00 H ATOM 9732 2H5'GUA 4 6.786 19.938 2.425 1.00 0.00 H ATOM 9733 H4'GUA 4 7.583 21.012 4.519 1.00 0.00 H ATOM 9734 H1'GUA 4 5.891 21.623 7.277 1.00 0.00 H ATOM 9735 1H2 GUA 4 5.014 19.561 11.508 1. 00 0.00 H ATOM 9736 2H2 GUA 4 3.440 19.108 12.119 1.00 0.00 H ATOM 9737 H1 GUA 4 1.616 19.100 10.837 1. 00 0.00 H ATOM 9738 H8 GUA 4 3.145 20.881 4.910 1.00 0.00 H ATOM 9739 H2'GUA 4 5.901 18. 878 7.124 1.00 0.00 H ATOM 9740 H02'GUA 4 8.086 20.625 6.501 1.00 0.00 H ATOM 9741 H3'GUA 4 5.515 18.778 4. 762 1.00 0.00 H ATOM 9742 P CYT 5 7.660 16.964 5.123 1.00 0.00 P ATOM 9743 01P CYT 5 6.399 16.356 4.642 1.00 0.00 0 ATOM 9744 02P CYT 5 8.960 16.438 4.648 1.00 0.00 0 ATOM 9745 05'CYT 5 7.656 16.926 6.733 1.00 0.00 0 ATOM 9746 C5'CYT 5 8. 835 17.260 7.471 1.00 0.00 C ATOM 9747 C4'CYT 5 8.685 16.924 8.952 1.00 0.00 C ATOM 9748 04'CYT 5 7.656 17.700 9.574 1.00 0.00 O ATOM 9749 C1'CYT 5 6.934 16.876 10.512 1.00 0.00 C ATOM 9750 N1 CYT 5 5.519 16.717 10.110 1.00 0.00 N ATOM 9751 C6 CYT 5 5.161 16.710 8.792 1.00 0.00 C ATOM 9752 C2 CYT 5 4.573 16.578 11.118 1.00 0.00 C ATOM 9753 02 CYT 5 4.919 16.584 12. 29S 1.00 0.00 0 ATOM 9754 N3 CYT 5 3.267 16.436 10.762 1.00 0. 00 N ATOM 9755 C4 CYT 5 2.902 16. 430 9.474 1. 00 0.00 C ATOM 9756 N4 CYT 5 1.613 16.299 9.162 1.00 0. 00 N

ATOM 9757 C5 CYT 5 3.872 16.569 8.433 1.00 0.00 C ATOM 9758 C2'CYT 5 7.653 15.529 10.535 1.00 0.00 C ATOM 9759 02'CYT 5 8.664 15.489 11.549 1.00 0.00 0 ATOM 9760 C3'CYT 5 8.251 15.484 9.144 1.00 0.00 C ATOM 9761 03'CYT 5 9.415 14.653 9.163 1.00 0.00 0 ATOM 9762 1H5'CYT 5 9.033 18.327 7.366 1.00 0.00 H ATOM 9763 2H5'CYT 5 9.678 16.700 7.064 1.00 0.00 H ATOM 9764 H4'CYT 5 9. 629 17.095 9.466 1.00 0.00 H ATOM 9765 Hl'CYT 5 6.982 17.329 11.503 1.00 0.00 H ATOM 9766 H6 CYT 5 5.926 16.820 8.024 1.00 0.00 H ATOM 9767 1H4 CYT 5 0.925 16.201 9.894 1.00 0.00 H ATOM 9768 2H4 CYT 5 1.325 16.298 8.195 1.00 0.00 H ATOM 9769 H5 CYT 5 3.580 16.557 7.384 1.00 0.00 H ATOM 9770 H2'CYT 5 6.931 14.720 10.666 1.00 0.00 H ATOM 9771 H02'CYT 5 9.238 16.246 11.409 1.00 0.00 H ATOM 9772 H3'CYT 5 7.522 15.171 8.395 1.00 0. 00 H ATOM 9773 P URI 6 9.312 13.099 8.757 1.00 0.00 P ATOM 9774 01P URI 6 8.423 12.985 7.578 1.00 0.00 0 ATOM 9775 02P URI 6 10.681 12.541 8.706 1.00 0.00 O ATOM 9776 05'URI 6 8.551 12.460 10.024 1.00 0.00 0 ATOM 9777 C5'URI 6 9.219 12.331 11.282 1.00 0.00 C ATOM 9778 C4'URI 6 8.254 11.930 12.392 1.00 0.00 C ATOM 9779 04'URI 6 7.228 12.911 12.584 1.00 0.00 0 ATOM 9780 C1'URI 6 5.974 12.249 12.842 1.00 0.00 C ATOM 9781 N1 URI 6 4.990 12.517 11.768 1.00 0.00 N ATOM 9782 C6 URI 6 5.385 12.667 10.464 1.00 0.00 C ATOM 9783 C2 URI 6 3.658 12.619 12. 134 1.00 0.00 C ATOM 9784 02 URI 6 3. 285 12.483 13.297 1.00 0.00 0 ATOM 9785 N3 URI 6 2.765 12.882 11.113 1.00 0.00 N ATOM 9786 C4 URI 6 3.080 13.049 9.775 1.00 0.00 C ATOM 9787 04 URI 6 2.202 13. 290 8.951 1.00 0.00 0 ATOM 9788 C5 URI 6 4.489 12.924 9. 481 1.00 0.00 C ATOM 9789 C2'URI 6 6.295 10.761 12.942 1.00 0.00 C ATOM 9790 02'URI 6 6.601 10.382 14.289 1.00 0.00 0 ATOM 9791 C3'URI 6 7.508 10.656 12.041 1.00 0.00 C ATOM 9792 03'URI 6 8.296 9.534 12.452 1.00 0.00 0 ATOM 9793 lH5'URI 6 9.682 13.284 11.540 1.00 0.00 H ATOM 9794 2H5'URI 6 9.996 11.571 11.194 1.00 0.00 H ATOM 9795 H4'URI 6 8.800 11.792 13.324 1.00 0.00 H ATOM 9796 H1'URI 6 5.572 12.593 13.795 1.00 0.00 H ATOM 9797 H6 URI 6 6.442 12.579 10.213 1.00 0.00 H ATOM 9798 H3 URI 6 1.790 12.956 11.367 1. 00 0.00 H ATOM 9799 H5 URI 6 4.835 13.035 8.453 1.00 0.00 H ATOM 9800 H2'URI 6 5.470 10.169 12.544 1.00 0.00 H ATOM 9801 H02'URI 6 5.769 10.326 14.765 1.00 0.00 H ATOM 9802 H3'URI 6 7.233 10.616 10.986 1.00 0. 00 H ATOM 9803 P CYT 7 8.046 8.079 11.809 1.00 0.00 P ATOM 9804 O1P CYT 7 7.894 8.238 10.345 1.00 0.00 0 ATOM 9805 02P CYT 7 9.066 7.152 12.348 1.00 0. 00 0 ATOM 9806 05'CYT 7 6.614 7.666 12.421 1.00 0. 00 0 ATOM 9807 C5'CYT 7 6.443 7.524 13.834 1.00 0.00 C ATOM 9808 C4'CYT 7 4.968 7.513 14.226 1. 00 0.00 C ATOM 9809 04'CYT 7 4.276 8.665 13.730 1.00 0.00 0 ATOM 9810 C1'CYT 7 2.945 8.284 13.322 1.00 0.00 C ATOM 9811 N1 CYT 7 2.739 8.485 11.868 1.00 0.00 N ATOM 9812 C6 CYT 7 3.789 8.738 11. 032 1.00 0.00 C ATOM 9813 C2 CYT 7 1.437 8.403 11.390 1.00 0.00 C ATOM 9814 02 CYT 7 0.507 8.173 12.161 1.00 0.00 0 ATOM 9815 N3 CYT 7 1.225 8.581 10.058 1.00 0.00 N ATOM 9816 C4 CYT 7 2. 244 8.830 9.226 1.00 0.00 C

ATOM 9817 N4 CYT 7 2.000 8.998 7.927 1.00 0.00 N ATOM 9818 C5 CYT 7 3.587 8.915 9.712 1.00 0.00 C ATOM 9819 C2'CYT 7 2.798 6.811 13.695 1.00 0. 00 C ATOM 9820 02'CYT 7 2.272 6.657 15.018 1.00 0.00 0 ATOM 9821 C3'CYT 7 4.234 6.338 13.608 1.00 0.00 C ATOM 9822 03'CYT 7 4.394 5.195 14.455 1.00 0.00 0 ATOM 9823 1H5'CYT 7 6.937 8.356 14.337 1.00 0.00 H ATOM 9824 2H5'CYT 7 6.903 6.590 14.156 1.00 0.00 H ATOM 9825 H4'CYT 7 4.874 7.476 15.310 1.00 0.00 H ATOM 9826 Hl'CYT 7 2.215 8.873 13.877 1.00 0.00 H ATOM 9827 H6 CYT 7 4.799 8.793 11.435 1.00 0.00 H ATOM 9828 1H4 CYT 7 2.761 9.186 7.290 1.00 0.00 H ATOM 9829 2H4 CYT 7 1.053 8.937 7.580 1.00 0.00 H ATOM 9830 H5 CYT 7 4.419 9.118 9.037 1.00 0.00 H ATOM 9831 H2'CYT 7 2.178 6.291 12.959 1.00 0.00 H ATOM 9832 H02'CYT 7 2.785 5.971 15.451 1.00 0.00 H ATOM 9833 H3'CYT 7 4.544 6.151 12.579 1.00 0.00 H ATOM 9834 P ADE 8 4.179 3.708 13.871 1.00 0.00 P ATOM 9835 O1P ADE 8 5.022 3.557 12.664 1.00 0.00 0 ATOM 9836 02P ADE 8 4.314 2.748 14.990 1.00 0.00 0 ATOM 9837 05'ADE 8 2.636 3.731 13.408 1.00 0.00 0 ATOM 9838 C5'ADE 8 1.585 3.816 14.375 1.00 0.00 C ATOM 9839 C4'ADE 8 0.218 3.961 13.712 1.00 0.00 C ATOM 9840 04'ADE 8 0.157 5.126 12.869 1.00 0.00 0 ATOM 9841 C1'ADE 8-0.418 4.763 11.598 1.00 0.00 C ATOM 9842 N9 ADE 8 0.618 4.675 10.547 1.00 0.00 N ATOM 9843 C4 ADE 8 0.413 4.671 9.183 1.00 0.00 C ATOM 9844 N3 ADE 8-0.773 4.768 8.549 1.00 0.00 N ATOM 9845 C2 ADE 8-0.620 4.732 7.228 1.00 0.00 C ATOM 9846 N1 ADE 8 0.525 4.615 6.552 1.00 0.00 N ATOM 9847 C6 ADE 8 1.695 4.519 7.206 1.00 0.00 C ATOM 9848 N6 ADE 8 2.826 4.399 6.512 1.00 0.00 N ATOM 9849 C5 ADE 8 1.656 4.547 8.604 1.00 0.00 C ATOM 9850 N7 ADE 8 2.654 4.473 9.579 1.00 0.00 N ATOM 9851 C8 ADE 8 1.964 4.555 10.666 1.00 0. 00 C ATOM 9852 C2'ADE 8-1.072 3.413 11.830 1.00 0.00 C ATOM 9853 02'ADE 8-2.370 3.548 12.424 1.00 0.00 0 ATOM 9854 C3'ADE 8-0.077 2.792 12.784 1.00 0.00 C ATOM 9855 03'ADE 8-0.725 1.754 13.527 1.00 0.00 O ATOM 9856 1H5'ADE 8 1.760 4.677 15.018 1.00 0.00 H ATOM 9857 2H5'ADE 8 1.590 2.911 14.984 1.00 0.00 H ATOM 9858 H4'ADE 8-0.556 4.028 14.475 1.00 0.00 H ATOM 9859 H1'ADE 8-1.173 5.492 11.313 1.00 0.00 H ATOM 9860 H2 ADE 8-1.529 4.808 6.630 1.00 0.00 H ATOM 9861 1H6 ADE 8 2.800 4.383 5.503 1.00 0.00 H ATOM 9862 2H6 ADE 8 3.710 4.323 6.996 1.00 0.00 H ATOM 9863 H8 ADE 8 2.444 4.527 11.644 1.00 0.00 H ATOM 9864 H2'ADE 8-1.119 2. 849 10.896 1.00 0.00 H ATOM 9865 H02'ADE 8-2.266 4.078 13.218 1.00 0.00 H ATOM 9866 H3'ADE 8 0.817 2. 445 12.267 1.00 0.00 H ATOM 9867 P ADE 9 0.126 0.524 14.130 1.00 0.00 P ATOM 9868 01P ADE 9 1.079 1.061 15.127 1.00 0.00 0 ATOM 9869 02P ADE 9-0.820-0. 546 14.518 1.00 0.00 0 ATOM 9870 05'ADE 9 0.967 0.013 12.851 1.00 0.00 0 ATOM 9871 C5'ADE 9 1.731-1. 199 12.912 1.00 0.00 C ATOM 9872 C4'ADE 9 2.574-1. 407 11.651 1.00 0.00 C ATOM 9873 04'ADE 9 1.767-1. 379 10.470 1.00 0.00 0 ATOM 9874 C1'ADE 9 1.953-0. 125 9.789 1.00 0.00 C ATOM 9875 N9 ADE 9 0.653 0.474 9.446 1.00 0. 00 N ATOM 9876 C4 ADE 9 0.237 0.879 8.202 1.00 0.00 C

ATOM 9877 N3 ADE 9 0.960 0.835 7.070 1.00 0. fla N ATOM 9878 C2 ADE 9 0.266 1.297 6.039 1.00 0. 00 C ATOM 9879 N1 ADE 9-0.984 1.761 6.048 1.00 0.00 N ATOM 9880 C6 ADE 9-1.687 1.796 7.192 1.00 0.00 C ATOM 9881 N6 ADE 9-2.936 2.260 7.181 1.00 0.00 N ATOM 9882 C5 ADE 9-1.053 1.330 8.348 1.00 0.00 C ATOM 9883 N7 ADE 9-1.469 1.220 9.678 1.00 0.00 N ATOM 9884 C8 ADE 9-0.418 0.718 10.235 1.00 0.00 C ATOM 9885 C2'ADE 9 2.740 0.758 10.750 1.00 0.00 C ATOM 9886 02'ADE 9 3.549 1.715 10.055 1.00 0.00 O ATOM 9887 C3'ADE 9 3.581-0. 281 11.459 1.00 0.00 C ATOM 9888 03'ADE 9 4.602-0. 709 10.545 1.00 0.00 O ATOM 9889 1H5'ADE 9 1.048-2. 042 13.024 1.00 0.00 H ATOM 9890 2H5'ADE 9 2.391-1. 160 13.778 1.00 0.00 H ATOM 9891 H4'ADE 9 3.092-2. 363 11.710 1.00 0.00 H ATOM 9892 H1'ADE 9 2.537-0. 283 8.881 1.00 0.00 H ATOM 9893 H2 ADE 9 0.771 1.285 5.077 1.00 0.00 H ATOM 9894 1H6 ADE 9-3.471 2.288 8.037 1.00 0.00 H ATOM 9895 2H6 ADE 9-3.347 2.584 6.317 1.00 0.00 H ATOM 9896 H8 ADE 9-0.391 0.503 11.301 1.00 0.00 H ATOM 9897 H2'ADE 9 2.068 1.243 11.459 1.00 0.00 H ATOM 9898 H02'ADE 9 2.956 2.370 9.679 1.00 0.00 H ATOM 9899 H3'ADE 9 3.982 0.081 12.401 1.00 0.00 H ATOM 9900 P URI 10 5.524-2. 003 10.823 1.00 0.00 P ATOM 9901 OIT URI 10 4.658-3. 119 11.266 1.00 0.00 0 ATOM 9902 02P URI 10 6.675-1. 584 11.655 1.00 0.00 O ATOM 9903 05'URI 10 6.063-2. 335 9.343 1.00 0.00 O ATOM 9904 C5'URI 10 6.138-3. 680 8.860 1.00 0.00 C ATOM 9905 C4'URI 10 5.263-3. 869 7.620 1.00 0.00 C ATOM 9906 04'URI 10 5.394-2. 774 6.710 1.00 0.00 0 ATOM 9907 C1'URI 10 6.264-3. 143 5.625 1.00 0.00 C ATOM 9908 N1 URI 10 7.362-2. 163 5.476 1.00 0.00 N ATOM 9909 C6 URI 10 7.601-1. 224 6.446 1.00 0.00 C ATOM 9910 C2 URI 10 8.131-2. 224 4.325 1. 00 0.00 C ATOM 9911 02 URI 10 7.929-3. 056 3.442 1.00 0.00 O ATOM 9912 N3 URI 10 9.143-1. 287 4.222 1.00 0.00 N ATOM 9913 C4 URI 10 9.450-0. 309 5.152 1.00 0.00 C ATOM 9914 04 URI 10 10.376 0.474 4.954 1.00 0.00 O ATOM 9915 C5 URI 10 8.598-0. 318 6.320 1.00 0.00 C ATOM 9916 C2'URI 10 6.801-4. 535 5.963 1.00 0.00 C ATOM 9917 02'URI 10 7.005-5. 325 4.786 1.00 O. 00 O ATOM 9918 C3'URI 10 5.683-5. 093 6.825 1.00 0.00 C ATOM 9919 03'URI 10 4.597-5. 475 5.968 1.00 0.00 O ATOM 9920 1H5'URI 10 5.807-4. 366 9.640 1.00 0.00 H ATOM 9921 2H5'URI 10 7.173-3. 904 8.603 1.00 0.00 H ATOM 9922 H4'URI 10 4.221-3. 965 7.920 1.00 0.00 H ATOM 9923 Hl'URI 10 5.689-3. 191 4.699 1.00 0.00 H ATOM 9924 H6 URI 10 6.972-1. 205 7.338 1.00 0.00 H ATOM 9925 H3 URI 10 9.712-1. 320 3.388 1.00 0.00 H ATOM 9926 H5 URI 10 8.759 0.415 7.110 1.00 0.00 H ATOM 9927 H2'URI 10 7.720-4. 453 6.550 1.00 0. 00 H ATOM 9928 H02'URI 10 7.188-6. 223 5.072 1.00 0.00 H ATOM 9929 H3'URI 10 6.018-5. 910 7.466 1.00 0.00 H ATOM 9930 P GUA 11 3.311-6. 248 6.554 1.00 0.00 P ATOM 9931 01P GUA 11 3.785-7. 409 7.340 1.00 0. 00 0 ATOM 9932 02P GUA 11 2.350-6. 450 5.447 1.00 0.00 O ATOM 9933 05'GUA 11 2.684-5. 167 7.572 1.00 0.00 O ATOM 9934 C5'GUA 11 2.101-5. 581 8.813 1. 0-0 0.00 C ATOM 9935 C4'GUA 11 0.780-4. 865 9.079 1.00 0.00 C ATOM 9936 04'GUA 11 0.951-3. 440 9.134 1.00 0. 00 O

ATOM 9937 C1'GUA 11-0. 038-2.807 8.302 1.00 0.00 C ATOM 9938 N9 GUA 11 0.550-2. 351 7.031 1.00 0.00 N ATOM 9939 C4 GUA 11-0.120-1. 772 5.979 1.00 0.00 C ATOM 9940 N3 GUA 11-1.444-1. 504 5.937 1.00 0.00 N ATOM 9941 C2 GUA 11-1.806-0. 937 4.784 1.00 0.00 C ATOM 9942 N2 GUA 11-3.079-0. 603 4.579 1.00 0.00 N ATOM 9943 N1 GUA 11-0.927-0. 662 3.757 1.00 0.00 N ATOM 9944 C6 GUA 11 0.436-0. 928 3.777 1.00 0.00 C ATOM 9945 06 GUA 11 1.135-0. 643 2.808 1.00 0.00 0 ATOM 9946 C5 GUA 11 0.831-1. 530 5.000 1.00 0.00 C ATOM 9947 N7 GUA 11 2.094-1. 950 5.427 1.00 0.00 N ATOM 9948 C8 GUA 11 1.833-2. 407 6.604 1.00 0.00 C ATOM 9949 C2'GUA 11-1.093-3. 875 8.059 1.00 0.00 C ATOM 9950 02'GUA 11-2.012-3. 973 9.154 1.00 0.00 0 ATOM 9951 C3'GUA 11-0.212-5. 101 7.950 1.00 0.00 C ATOM 9952 03'GUA 11-0.987-6. 265 8.251 1.00 0.00 0 ATOM 9953 1H5'GUA 11 2.795-5. 358 9.623 1.00 0.00 H ATOM 9954 2H5'GUA 11 1.922-6. 656 8.783 1.00 0.00 H ATOM 9955 H4'GUA 11 0.355-5. 214 10.019 1.00 0.00 H ATOM 9956 H1'GUA 11-0.478-1. 958 8.828 1.00 0.00 H ATOM 9957 1H2 GUA 11-3.354-0. 174 3.707 1.00 0.00 H ATOM 9958 2H2 GUA 11-3.769-0. 778 5.295 1.00 0.00 H ATOM 9959 H1 GUA 11-1.281-0. 233 2.914 1.00 0.00 H ATOM 9960 H8 GUA 11 2.616-2. 821 7.237 1.00 0.00 H ATOM 9961 H2'GUA 11-1.615-3. 690 7.115 1.00 0.00 H ATOM 9962 H02'GUA 11-2.567-3. 190 9.131 1.00 0.00 H ATOM 9963 H3'GUA 11 0.281-5. 163 6.978 1.00 0.00 H ATOM 9964 P CYT 12-1.425-7. 274 7.075 1.00 0.00 P ATOM 9965 01P CYT 12-2.226-8. 365 7.674 1.00 0.00 0 ATOM 9966 02P CYT 12-0. 226-7.596 6.269 1.00 0.00 0 ATOM 9967 05'CYT 12-2.402-6. 359 6.182 1.00 0.00 0 ATOM 9968 C5'CYT 12-3.700-6. 002 6.664 1.00 0.00 C ATOM 9969 C4'CYT 12-4.467-5. 161 5.649 1. 00 0.00 C ATOM 9970 04'CYT 12-3.813-3. 916 5.381 1.00 0.00 0 ATOM 9971 C1'CYT 12-3.922-3. 611 3.976 1.00 0.00 C ATOM 9972 N1 CYT 12-2.594-3. 606 3.320 1.00 0.00 N ATOM 9973 C6 CYT 12-1.486-4. 074 3.968 1.00 0.00 C ATOM 9974 C2 CYT 12-2.516-3. 094 2.030 1.00 0.00 C ATOM 9975 02 CYT 12-3.528-2. 690 1.460 1.00 0.00 O ATOM 9976 N3 CYT 12-1.300-3. 065 1.421 1.00 0.00 N ATOM 9977 C4 CYT 12-0.206-3. 519 2.045 1.00 0.00 C ATOM 9978 N4 CYT 12 0.971-3. 465 1.423 1. 00 0.00 N ATOM 9979 C5 CYT 12-0.282-4. 050 3.370 1.00 0.00 C ATOM 9980 C2'CYT 12-4.827-4. 687 3.381 1.00 0.00 C ATOM 9981 02'CYT 12-6.204-4. 297 3.428 1.00 0.00 0 ATOM 9982 C3'CYT 12-4.542-5. 854 4.302 1. 00 0.00 C ATOM 9983 03'CYT 12-5.667-6. 736 4.303 1.00 0.00 0 ATOM 9984 1H5'CYT 12-3.594-5. 435 7.589 1. 00 0.00 H ATOM 9985 2H5'CYT 12-4.264-6. 913 6.868 1.00 0.00 H ATOM 9986 H4'CYT 12-5.473-4. 967 6.018 1. 00 0.00 H ATOM 9987 H1'CYT 12-4.393-2. 635 3.854 1.00 0.00 H ATOM 9988 H6 CYT 12-1.577-4. 468 4.981 1.00 0.00 H ATOM 9989 1H4 CYT 12 1. 803-3. 798 1.888 1.00 0.00 H ATOM 9990 2H4 CYT 12 1. 030-3. 087 0.488 1.00 0.00 H ATOM 9991 H5 CYT 12 0.606-4. 425 3.879 1.00 0.00 H ATOM 9992 H2'CYT 12-4.518-4. 920 2.360 1.00 0.00 H ATOM 9993 H02'CYT 12-6.294-3. 513 2.882 1.00 0.00 H ATOM 9994 H3'CYT 12-3.609-6. 358 4.042 1.00 0.00 H ATOM 9995 P URI 13-5.644-8. 082 3.421 1.00 0.00 P ATOM 9996 01P URI 13-4. 304-8. 698 3.547 1.00 0.00 O

ATOM 9997 02P URI 13-6.853-8. 871 3.747 1. 00 0.00 0 ATOM 9998 05'URI 13-5.797-7. 514 1.924 1.00 0.00 0 ATOM 9999 C5'URI 13-7.046-6. 980 1.476 1.00 0.00 C ATOM 10000 C4'URI 13-6.915-6. 316 0.109 1.00 0.00 C ATOM 10001 04'URI 13-6.008-5. 210 0.139 1.00 0.00 0 ATOM 10002 C1'URI 13-5.260-5. 172-1.093 1.00 0.00 C ATOM 10003 N1 URI 13-3.809-5. 342-0.854 1.00 0.00 N ATOM 10004 C6 URI 13-3.340-5. 938 0.289 1.00 0.00 C ATOM 10005 C2 URI 13-2.945-4. 870-1. 827 1.00 0.00 C ATOM 10006 02 URI 13-3.346-4. 339-2.860 1.00 0.00 O ATOM 10007 N3 URI 13-1.597-5. 034-1.573 1. 00 0.00 N ATOM 10008 C4 URI 13-1.041-5. 618-0.450 1.00 0.00 C ATOM 10009 04 URI 13 0.179-5. 700-0.326 1.00 0.00 0 ATOM 10010 C5 URI 13-2.012-6. 085 0.513 1.00 0.00 C ATOM 10011 C2'URI 13-5.808-6. 305-1.960 1.00 0.00 C ATOM 10012 02'URI 13-6.861-5. 848-2. 818 1. 00 0.00 O ATOM 10013 C3'URI 13-6.320-7. 269-0.910 1.00 0.00 C ATOM 10014 03'URI 13-7.371-8. 057-1.475 1.00 0.00 0 ATOM 10015 1H5'URI 13-7.398-6. 242 2.197 1.00 0.00 H ATOM 10016 2H5'URI 13-7.774-7. 788 1.409 1. 00 0.00 H ATOM 10017 H4'URI 13-7.891-5. 975-0. 232 1.00 0.00 H ATOM 10018 H1'URI 13-5. 436-4. 219-1. 592 1.00 0.00 H ATOM 10019 H6 URI 13-4.049-6. 305 1.032 1.00 0.00 H ATOM 10020 H3 URI 13-0.957-4. 697-2. 277 1.00 0.00 H ATOM 10021 H5 URI 13-1.672-6. 563 1.432 1.00 0.00 H ATOM 10022 H2'URI 13-5.002-6. 763-2.537 1.00 0.00 H ATOM 10023 H02'URI 13-6.459-5. 305-3.500 1.00 0.00 H ATOM 10024 H3'URI 13-5.518-7. 875-0.487 1.00 0.00 H ATOM 10025 P CYT 14-7. 044-9.469-2. 176 1.00 0.00 P ATOM 10026 01P CYT 14-6.064-10. 189-1.332 1.00 0.00 0 ATOM 10027 02P CYT 14-8. 325-10.116-2. 535 1.00 0.00 O ATOM 10028 05'CYT 14-6.304-9. 021-3.534 1.00 0.00 0 ATOM 10029 C5'CYT 14-7. 059-8.544-4. 651 1.00 0.00 C ATOM 10030 C4'CYT 14-6.153-8. 144-5.812 1.00 0.00 C ATOM 10031 04'CYT 14-5.268-7. 080-5.453 1.00 0.00 0 ATOM 10032 C1'CYT 14-3. 996-7.276-6. 105 1.00 0.00 C ATOM 10033 N1 CYT 14-2.898-7. 412-5.124 1.00 0.00 N ATOM 10034 C6 CYT 14-3. 125-7. 921-3. 878 1.00 0.00 C ATOM 10035 C2 CYT 14-1.631-7. 008-5.521 1.00 0.00 C ATOM 10036 02 CYT 14-1.449-6. 561-6.652 1.00 0.00 O ATOM 10037 N3 CYT 14-0.608-7. 129-4.634 1.00 0.00 N ATOM 10038 C4 CYT 14-0. 815-7.626-3. 409 1.00 0.00 C ATOM 10039 N4 CYT 14 0.210-7. 728-2. 564 1.00 0.00 N ATOM 10040 C5 CYT 14-2.119-8. 044-2.995 1.00 0.00 C ATOM 10041 C2'CYT 14-4.132-8. 545-6.944 1.00 0.00 C ATOM 10042 02'CYT 14-4.501-8. 243-8. 295 1.00 0.00 0 ATOM 10043 C3'CYT 14-5.235-9. 283-6. 213 1.00 0.00 C ATOM 10044 03'CYT 14-5.921-10. 125-7. 144 1.00 0. 00 0 ATOM 10045 1H5'CYT 14-7.645-7. 678-4. 343 1.00 0.00 H ATOM 10046 2H5'CYT 14-7.736-9. 331-4.984 1.00 0.00 H ATOM 10047 H4'CYT 14-6.757-7. 840-6.666 1.00 0.00 H ATOM 10048 H1'CYT 14-3.794-6. 429-6. 761 1.00 0.00 H ATOM 10049 H6 CYT 14-4. 131-8.233-3. 596 1.00 0.00 H ATOM 10050 1H4 CYT 14 0. 065-8. 099-1. 636 1.00 0.00 H ATOM 10051 2H4 CYT 14 1.133-7. 439-2.854 1.00 0.00 H ATOM 10052 H5 CYT 14-2. 290-8. 454-2. 001 1.00 0.00 H ATOM 10053 H2'CYT 14-3. 203-9. 119-6. 908 1. 00 0.00 H ATOM 10054 H02'CYT 14-3. 741-7. 830-8. 713 1. 00 0.00 H ATOM 10055 H3'CYT 14-4. 857-9. 831-5. 348 1.00 0.00 H ATOM 10056 P URI 15-5. 453-11. 651-7. 360 1. 00 0. 00 P

ATOM 10057 01P URI 15-5.471-12. 332-6.046 1.00 0.00 0 ATOM 10058 02P URI 15-6.220-12. 215-8.493 1.00 0.00 O ATOM 10059 05'URI 15-3.918-11. 486-7.819 1.00 0.00 O ATOM 10060 C5'URI 15-3. 594-11.022-9. 134 1.00 0.00 C ATOM 10061 C4'URI 15-2.106-10. 703-9.269 1.00 0.00 C ATOM 10062 04'URI 15-1.695-9. 675-8.355 1.00 0.00 0 ATOM 10063 C1'URI 15-0.429-10. 037-7.765 1.00 0.00 C ATOM 10064 N1 URI 15-0.581-10. 383-6.333 1.00 0.00 N ATOM 10065 C6 URI 15-1. 721-10.986-5. 873 1.00 0.00 C ATOM 10066 C2 URI 15 0.473-10. 089-5.485 1.00 0.00 C ATOM 10067 02 URI 15 1.505-9. 552-5.880 1.00 0.00 0 ATOM 10068 N3 URI 15 0.301-10. 441-4.159 1.00 0.00 N ATOM 10069 C4 URI 15-0.815-11. 052-3.614 1.00 0.00 C ATOM 10070 04 URI 15-0.859-11. 320-2.416 1.00 0.00 0 ATOM 10071 C5 URI 15-1.864-11. 322-4.571 1.00 0. 00 C ATOM 10072 C2'URI 15 0.065-11. 238-8.562 1.00 0.00 C ATOM 10073 02'URI 15 0.786-10. 835-9.733 1.00 0.00 0 ATOM 10074 C3'URI 15-1.247-11. 904-8.913 1.00 0.00 C ATOM 10075 03'URI 15-1.064-12. 706-10.083 1.00 0.00 0 ATOM 10076 1H5'URI 15-4.171-10. 122-9.347 1.00 0.00 H ATOM 10077 2H5'URI 15-3.858-11. 793-9.857 1.00 0.00 H ATOM 10078 H4'URI 15-1.889-10. 386-10.288 1.00 0.00 H ATOM 10079 H1'URI 15 0.274-9. 211-7.871 1.00 0.00 H ATOM 10080 H6 URI 15-2.531-11. 200-6.569 1.00 0.00 H ATOM 10081 H3 URI 15 1.061-10. 233-3.529 1. 00 0.00 H ATOM 10082 H5 URI 15-2. 781-11. 807-4. 241 1.00 0.00 H ATOM 10083 H2'URI 15 0.671-11. 891-7.929 1.00 0.00 H ATOM 10084 H02'URI 15 1.592-10. 402-9.437 1.00 0.00 H ATOM 10085 H3'URI 15-1.657-12. 469-8.072 1.00 0.00 H ATOM 10086 P URI 16-0.508-14. 212-9.963 1.00 0.00 P ATOM 10087 01P URI 16-0.681-14. 875-11.274 1.00 0.00 O ATOM 10088 02P URI 16-1.084-14. 824-8.744 1.00 0.00 0 ATOM 10089 05'URI 16 1.069-13. 986-9.716 1.00 0.00 0 ATOM 10090 C5'URI 16 1.955-15. 103-9.592 1.00 0.00 C ATOM 10091 C4'URI 16 3.031-15. 086-10.672 1.00 0.00 C ATOM 10092 04'URI 16 2.456-14. 923-11.978 1.00 0.00 0 ATOM 10093 C1'URI 16 3.019-13. 768-12.611 1.00 0.00 C ATOM 10094 N1 URI 16 2. 020-13.078-13. 457 1.00 0.00 N ATOM 10095 C6 URI 16 0. 875-12. 555-12.916 1. 00 0.00 C ATOM 10096 C2 URI 16 2.284-12. 985-14.813 1.00 0.00 C ATOM 10097 02 URI 16 3.306-13. 449-15.317 1.00 0.00 0 ATOM 10098 N3 URI 16 1.329-12. 338-15.575 1.00 0.00 N ATOM 10099 C4 URI 16 0.149-11. 784-15.109 1.00 0.00 C ATOM 10100 04 URI 16-0.630-11. 231-15.881 1.00 0.00 0 ATOM 10101 C5 URI 16-0.046-11. 927-13.684 1.00 0.00 C ATOM 10102 C2'URI 16 3.489-12. 879-11. 472 1.00 0.00 C ATOM 10103 02'URI 16 4. 534-11.992-11. 888 1.00 0.00 0 ATOM 10104 C3'URI 16 3.989-13. 910-10.477 1.00 0.00 C ATOM 10105 03'URI 16 5.300-14. 331-10.870 1.00 0.00 O ATOM 10106 1H5'URI 16 1.384-16. 024-9.672 1.00 0.00 H ATOM 10107 2H5'URI 16 2.434-15. 073-8.616 1.00 0.00 H ATOM 10108 H4'URI 16 3.590-16. 020-10.641 1.00 0.00 H ATOM 10109 H1'URI 16 3.875-14. 065-13.218 1.00 0.00 H ATOM 10110 H6 URI 16 0. 701-12. 646-11.844 1.00 0.00 H ATOM 10111 H3 URI 16 1.509-12. 263-16. 566 1.00 0.00 H ATOM 10112 H5 URI 16-0. 946-11. 522-13. 222 1.00 0.00 H ATOM 10113 H2'URI 16 2. 646-12. 328-11. 047 1.00 0.00 H ATOM 10114 H02'URI 16 4.845-11. 531-11.105 1.00 0.00 H ATOM 10115 H3'URI 16 3.970-13. 533-9.454 1.00 0.00 H

ATOM 10116 P CYT 17 6.135-15. 357-9. 951 1.00 0.00 P ATOM 10117 01P CYT 17 7.551-15. 317-10.379 1.00 0.00 O ATOM 10118 02P CYT 17 5.411-16. 648-9.917 1.00 0.00 O ATOM 10119 05'CYT 17 6.027-14. 680-8.493 1.00 0.00 O ATOM 10120 C5'CYT 17 6.742-13. 477-8.201 1.00 0.00 C ATOM 10121 C4'CYT 17 6.531-13. 022-6.763 1.00 0.00 C ATOM 10122 04'CYT 17 5.161-12. 677-6.517 1.00 0.00 0 ATOM 10123 C1'CYT 17 4.716-13. 347-5.339 1.00 0.00 C ATOM 10124 N1 CYT 17 3.264-13. 605-5.382 1.00 0.00 N ATOM 10125 C6 CYT 17 2.612-13. 698-6.571 1.00 0.00 C ATOM 10126 C2 CYT 17 2.591-13. 737-4.173 1.00 0.00 C ATOM 10127 02 CYT 17 3.203-13. 648-3.109 1.00 0.00 0 ATOM 10128 N3 CYT 17 1.249-13. 964-4.205 1.00 0.00 N ATOM 10129 C4 CYT 17 0.596-14. 058-5.370 1.00 0.00 C ATOM 10130 N4 CYT 17-0.719-14. 278-5.367 1.00 0.00 N ATOM 10131 C5 CYT 17 1.289-13. 923-6.613 1.00 0.00 C ATOM 10132 C2'CYT 17 5.515-14. 635-5.312 1.00 0.00 C ATOM 10133 02'CYT 17 5.576-15. 196-3.994 1.00 0.00 O ATOM 10134 C3'CYT 17 6.876-14. 143-5.781 1.00 0.00 C ATOM 10135 03'CYT 17 7.562-13. 566-4.663 1.00 0.00 O ATOM 10136 1H5'CYT 17 6.405-12. 692-8.871 1.00 0.00 H ATOM 10137 2H5'CYT 17 7.801-13. 651-8.364 1.00 0.00 H ATOM 10138 H4'CYT 17 7.161-12. 157-6.561 1. 00 0.00 H ATOM 10139 H1'CYT 17 4.958-12. 749-4.465 1.00 0.00 H ATOM 10140 H6 CYT 17 3.169-13. 584-7.500 1.00 0.00 H ATOM 10141 1H4 CYT 17-1.221-14. 349-6.241 1.00 0.00 H ATOM 10142 2H4 CYT 17-1.213-14. 374-4.492 1.00 0.00 H ATOM 10143 H5 CYT 17 0.767-14. 003-7.563 1.00 0.00 H ATOM 10144 H2'CYT 17 5.105-15. 350-6.031 1.00 0.00 H ATOM 10145 H02'CYT 17 4.679-15. 424-3.740 1.00 0.00 H ATOM 10146 H3'CYT 17 7.455-14. 931-6.260 1.00 0.00 H ATOM 10147 P GUA 18 9.163-13. 685-4.527 1.00 0.00 P ATOM 10148 01P GUA 18 9.550-15. 083-4.819 1.00 0.00 O ATOM 10149 02P GUA 18 9.567-13. 061-3.246 1.00 0.00 O ATOM 10150 05'GUA 18 9.693-12. 755-5.730 1.00 0.00 O ATOM 10151 C5'GUA 18 9.546-11. 332-5. 676 1.00 0.00 C ATOM 10152 C4'GUA 18 9.854-10. 688-7.026 1.00 0.00 C ATOM 10153 04'GUA 18 8. 987-11. 178-8.046 1.00 0.00 0 ATOM 10154 C1'GUA 18 8.712-10. 131-8.992 1.00 0.00 C ATOM 10155 N9 GUA 18 7.258-9. 940-9.164 1.00 0.00 N ATOM 10156 C4 GUA 18 6.307-9. 870-8.167 1.00 0.00 C ATOM 10157 N3 GUA 18 6.543-9. 942-6.837 1.00 0.00 N ATOM 10158 C2 GUA 18 5.420-9. 847-6.119 1.00 0.00 C ATOM 10159 N2 GUA 18 5.473-9. 901-4.788 1.00 0. 00 N ATOM 10160 N1 GUA 18 4.165-9. 693-6.676 1.00 0.00 N ATOM 10161 C6 GUA 18 3.898-9. 616-8.036 1.00 0.00 C ATOM 10162 06 GUA 18 2.743-9. 479-8.431 1.00 0.00 O ATOM 10163 C5 GUA 18 5.086-9. 717-8.807 1.00 0.00 C ATOM 10164 N7 GUA 18 5.257-9. 686-10.193 1.00 0.00 N ATOM 10165 C8 GUA 18 6.535-9. 820-10. 305 1.00 0.00 C ATOM 10166 C2'GUA 18 9.386-8. 863-8.460 1.00 0.00 C ATOM 10167 02'GUA 18 10.624-8. 609-9.136 1.00 0.00 O ATOM 10168 C3'GUA 18 9.611-9. 191-6.992 1.00 0.00 C ATOM 10169 03'GUA 18 10.818-8. 550-6.560 1.00 0.00 O ATOM 10170 1H5'GUA 18 10.229-10. 931-4.926 1.00 0.00 H ATOM 10171 2H5'GUA 18 8.522-11. 090-5.392 1.00 0.00 H ATOM 10172 H4'GUA 18 10.888-10. 888-7.303 1.00 0. 00 H ATOM 10173 H1'GUA 18 9.155-10. 394-9.953 1.00 0.00 H ATOM 10174 1H2 GUA 18 4.625-9. 829-4.244 1.00 0.00 H

ATOM 10175 2H2 GUA 18 6.363-10. 012-4.323 1.00 0.00 H ATOM 10176 Hl GUA 18 3.363-9. 631-6.064 1.00 0.00 H ATOM 10177 H8 GUA 18 7.017-9. 837-11.283 1. 00 0. 00 H ATOM 10178 H2'GUA 18 8.709-8. 009-8.556 1.00 0.00 H ATOM 10179 H02'GUA 18 11.174-9. 387-9.024 1.00 0.00 H ATOM 10180 H3'GUA 18 8. 751-8. 925-6.377 1.00 0.00 H ATOM 10181 P GUA 19 10.806-7. 023-6.046 1.00 0.00 P ATOM 10182 01P GUA 19 12.203-6. 613-5.780 1.00 0.00 0 ATOM 10183 02P GUA 19 9.786-6. 903-4.979 1. 00 0.00 0 ATOM 10184 05'GUA 19 10.284-6. 218-7.341 1.00 0.00 O ATOM 10185 C5'GUA 19 9.336-5. 155-7.205 1.00 0.00 C ATOM 10186 C4'GUA 19 8.366-5. 114-8.383 1.00 0.00 C ATOM 10187 04'GUA 19 7.667-6. 361-8.529 1.00 0.00 0 ATOM 10188 C1'GUA 19 6.252-6. 116-8.588 1.00 0.00 C ATOM 10189 N9 GUA 19 5.604-6. 424-7.297 1.00 0.00 N ATOM 10190 C4 GUA 19 4.250-6. 497-7.055 1.00 0.00 C ATOM 10191 N3 GUA 19 3.269-6. 300-7.965 1.00 0.00 N ATOM 10192 C2 GUA 19 2.052-6. 437-7.432 1.00 0.00 C ATOM 10193 N2 GUA 19 0.970-6. 270-8.191 1.00 0.00 N ATOM 10194 N1 GUA 19 1.827-6. 744-6.105 1.00 0.00 N ATOM 10195 C6 GUA 19 2.817-6. 950-5.153 1.00 0.00 C ATOM 10196 06 GUA 19 2.511-7. 223-3.995 1.00 0.00 O ATOM 10197 C5 GUA 19 4.114-6. 806-5.710 1.00 0.00 C ATOM 10198 N7 GUA 19 5.367-6. 929-5.103 1.00 0.00 N ATOM 10199 C8 GUA 19 6.162-6. 693-6.091 1.00 0.00 C ATOM 10200 C2'GUA 19 6.114-4. 643-8.932 1.00 0.00 C ATOM 10201 02'GUA 19 6.235-4. 416-10.342 1.00 0.00 O ATOM 10202 C3'GUA 19 7.285-4. 061-8.165 1.00 0.00 C ATOM 10203 03'GUA 19 7.692-2. 846-8.802 1.00 0.00 O ATOM 10204 1H5'GUA 19 9.870-4. 206-7.151 1.00 0.00 H ATOM 10205 2H5'GUA 19 8.770-5. 297-6.284 1.00 0.00 H ATOM 10206 H4'GUA 19 8.911-4. 896-9.300 1.00 0.00 H ATOM 10207 H1'GUA 19 5.807-6. 722-9.377 1.00 0.00 H ATOM 10208 1H2 GUA 19 1.070-6. 041-9.170 1.00 0.00 H ATOM 10209 2H2 GUA 19 0.049-6. 372-7.789 1. 00 0.00 H ATOM 10210 Hl GUA 19 0.876-6. 830-5.778 1.00 0.00 H ATOM 10211 H8 GUA 19 7.244-6. 708-5.961 1.00 0.00 H ATOM 10212 H2'GUA 19 5.169-4. 249-8.547 1.00 0.00 H ATOM 10213 H02'GUA 19 5.457-4. 794-10.759 1.00 0.00 H ATOM 10214 H3'GUA 19 7.051-3. 925-7.108 1.00 0.00 H ATOM 10215 P ADE 20 7.149-1. 424-8.275 1.00 0.00 P ATOM 10216 O1P ADE 20 7.635-0. 372-9.195 1.00 0.00 O ATOM 10217 02P ADE 20 7.437-1. 327-6.826 1.00 0.00 O ATOM 10218 05'ADE 20 5.554-1. 565-8. 463 1.00 0.00 O ATOM 10219 C5'ADE 20 4.962-1. 459-9.761 1.00 0.00 C ATOM 10220 C4'ADE 20 3.451-1. 672-9.713 1.00 0.00 C ATOM 10221 04'ADE 20 3.110-2. 969-9.214 1. 00 0.00 O ATOM 10222 C1'ADE 20 1.927-2. 870-8. 393 1.00 0.00 C ATOM 10223 N9 ADE 20 2.209-3. 252-6.995 1.00 0.00 N ATOM 10224 C4 ADE 20 1.280-3. 563-6.027 1.00 0.00 C ATOM 10225 N3 ADE 20-0.060-3. 566-6.176 1.00 0.00 N ATOM 10226 C2 ADE 20-0.671-3. 913-5.048 1. 00 0.00 C ATOM 10227 N1 ADE 20-0. 099-4.230-3. 885 1.00 0.00 N ATOM 10228 C6 ADE 20 1.239-4. 221-3.761 1.00 0.00 C ATOM 10229 N6 ADE 20 1.789-4. 556-2. 594 1.00 0.00 N ATOM 10230 C5 ADE 20 1.989-3. 868-4. 888 1. 00 0.00 C ATOM 10231 N7 ADE 20 3.365-3. 754-5.114 1. 00 0.00 N ATOM 10232 C8 ADE 20 3.396-3. 395-6.354 1.00 0.00 C ATOM 10233 C2'ADE 20 1.473-1. 415-8.479 1. 00 0.00 C

ATOM 10234 02'ADE 20 0.535-1. 221-9.545 1.00 0.00 0 ATOM 10235 C3'ADE 20 2.784-0. 707-8.751 1.00 0.00 C ATOM 10236 03'ADE 20 2.513 0.519-9. 435 1.00 0.00 O ATOM 10237 1H5'ADE 20 5.406-2. 208-10.418 1.00 0.00 H ATOM 10238 2H5'ADE 20 5.168-0. 467-10.165 1.00 0.00 H ATOM 10239 H4'ADE 20 3.029-1. 547-10.710 1.00 0.00 H ATOM 10240 H1'ADE 20 1.149-3. 517-8.798 1.00 0.00 H ATOM 10241 H2 ADE 20-1. 760-3.941-5. 075 1.00 0.00 H ATOM 10242 1H6 ADE 20 2.794-4. 562-2.493 1.00 0.00 H ATOM 10243 2H6 ADE 20 1.202-4. 809-1.812 1.00 0.00 H ATOM 10244 H8 ADE 20 4.340-3. 209-6.866 1.00 0.00 H ATOM 10245 H2'ADE 20 1.055-1. 091-7.523 1.00 0.00 H ATOM 10246 H02'ADE 20 0.955-1. 521-10.354 1.00 0.00 H ATOM 10247 H3'ADE 20 3.368-0. 564-7.840 1.00 0.00 H ATOM 10248 P GUA 21 2.201 1.863-8. 604 1.00 0.00 P ATOM 10249 01P GUA 21 3.222 1.997-7. 540 1.00 0.00 O ATOM 10250 02P GUA 21 1.993 2.966-9. 568 1.00 0.00 0 ATOM 10251 05'GUA 21 0.789 1.525-7. 906 1.00 0.00 0 ATOM 10252 C5'GUA 21-0.434 1.665-8. 637 1.00 0.00 C ATOM 10253 C4'GUA 21-1.655 1.471-7. 741 1.00 0.00 C ATOM 10254 04'GUA 21-1.722 0.148-7. 201 1.00 0.00 0 ATOM 10255 C1'GUA 21-2.262 0.208-5. 865 1.00 0.00 C ATOM 10256 N9 GUA 21-1. 300-0.315-4. 873 1.00 0.00 N ATOM 10257 C4 GUA 21-1. 602-0.846-3. 638 1.00 0.00 C ATOM 10258 N3 GUA 21-2. 839-0.960-3. 105 1.00 0.00 N ATOM 10259 C2 GUA 21-2.816-1. 515-1.889 1.00 0.00 C ATOM 10260 N2 GUA 21-3.953-1. 691-1.215 1.00 0.00 N ATOM 10261 N1 GUA 21-1.659-1. 925-1.256 1.00 0.00 N ATOM 10262 C6 GUA 21-0.379-1. 819-1.783 1.00 0.00 C ATOM 10263 06 GUA 21 0.587-2. 226-1.141 1.00 0.00 0 ATOM 10264 C5 GUA 21-0.394-1. 227-3. 074 1.00 0.00 C ATOM 10265 N7 GUA 21 0.666-0. 940-3.940 1.00 0.00 N ATOM 10266 C8 GUA 21 0.049-0. 417-4.946 1.00 0.00 C ATOM 10267 C2'GUA 21-2. 580 1.679-5. 600 1.00 0.00 C ATOM 10268 02'GUA 21-3.936 1.993-5. 940 1.00 0.00 O ATOM 10269 C3'GUA 21-1.597 2.370-6. 522 1.00 0.00 C ATOM 10270 03'GUA 21-2. 112 3.659-6. 871 1.00 0.00 O ATOM 10271 1H5'GUA 21-0.458 0.924-9. 436 1.00 0.00 H ATOM 10272 2H5'GUA 21-0.471 2.662-9. 075 1.00 0.00 H ATOM 10273 H4'GUA 21-2.563 1.676-8. 306 1.00 0.00 H ATOM 10274 H1'GUA 21-3.183-0. 376-5.820 1.00 0.00 H ATOM 10275 1H2 GUA 21-4.831-1. 405-1.624 1.00 0.00 H ATOM 10276 2H2 GUA 21-3.935-2. 106-0.295 1.00 0.00 H ATOM 10277 Hl GUA 21-1.726-2. 336-0.336 1.00 0.00 H ATOM 10278 H8 GUA 21 0.595-0. 059-5.818 1.00 0.00 H ATOM 10279 H2'GUA 21-2.367 1.929-4. 559 1.00 0.00 H ATOM 10280 H02'GUA 21-4.490 1.688-5. 217 1.00 0.00 H ATOM 10281 H3'GUA 21-0.596 2.416-6. 091 1.00 0.00 H ATOM 10282 P ADE 22-1.781 4.945-5. 958 1.00 0.00 P ATOM 10283 01P ADE 22-2.159 6.159-6. 714 1.00 0.00 0 ATOM 10284 02P ADE 22-0.404 4.801-5. 434 1.00 0.00 0 ATOM 10285 05'ADE 22-2.807 4.775-4. 728 1.00 0.00 0 ATOM 10286 C5'ADE 22-4.207 4.999-4. 916 1.00 0. 00 C ATOM 10287 C4'ADE 22-5.029 4.466-3. 745 1.00 0.00 C ATOM 10288 04'ADE 22-4.787 3.072-3. 522 1.00 0.00 0 ATOM 10289 C1'ADE 22-4.753 2.813-2. 105 1.00 0.00 C ATOM 10290 N9 ADE 22-3.416 2.365-1. 671 1.00 0.00 N ATOM 10291 C4 ADE 22-3.133 1.572-0. 583 1.00 0.00 C ATOM 10292 N3 ADE 22-4. 027 1. 065 0.288 1.00 0.00 N ATOM 10293 C2 ADE 22-3.429 0.341 1.227 1. 00 0.00 C

ATOM 10294 N1 ADE 22-2.122 0.104 1.352 1.00 0.00 N ATOM 10295 C6 ADE 22-1.249 0.622 0.469 1.00 0.00 C ATOM 10296 N6 ADE 22 0.051 0.370 0.609 1.00 0.00 N ATOM 10297 C5 ADE 22-1.769 1. 405-0. 565 1.00 0.00 C ATOM 10298 N7 ADE 22-1. 170 2.083-1. 631 1.00 0.00 N ATOM 10299 C8 ADE 22-2.196 2.607-2. 213 1.00 0.00 C ATOM 10300 C2'ADE 22-5. 138 4.123-1. 427 1.00 0.00 C ATOM 10301 02'ADE 22-6.555 4.213-1. 232 1.00 0.00 O ATOM 10302 C3'ADE 22-4.647 5.138-2. 438 1.00 0.00 C ATOM 10303 03'ADE 22-5.412 6.340-2. 297 1.00 0.00 0 ATOM 10304 1H5'ADE 22-4. 528 4.500-5. 830 1. 00 0.00 H ATOM 10305 2H5'ADE 22-4.385 6.070-5. 015 1.00 0.00 H ATOM 10306 H4'ADE 22-6.089 4.619-3. 941 1.00 0.00 H ATOM 10307 H1'ADE 22-5.490 2.048-1. 859 1. 00 0.00 H ATOM 10308 H2 ADE 22-4. 078-0.109 1.979 1.00 0.00 H ATOM 10309 1H6 ADE 22 0.712 0. 753-0. 051 1.00 0.00 H ATOM 10310 2H6 ADE 22 0.376-0. 203 1.376 1.00 0.00 H ATOM 10311 H8 ADE 22-2.085 3.223-3. 106 1.00 0.00 H ATOM 10312 H2'ADE 22-4.602 4.234-0. 480 1.00 0.00 H ATOM 10313 HO2'ADE 22-6.969 4.099-2. 091 1.00 0.00 H ATOM 10314 H3'ADE 22-3.571 5. 308-2. 358 1.00 0.00 H ATOM 10315 P CYT 23-5.051 7.414-1. 151 1.00 0.00 P ATOM 10316 O1P CYT 23-3.585 7. 618-1.151 1.00 0.00 0 ATOM 10317 02P CYT 23-5.957 8.575-1. 302 1.00 0.00 0 ATOM 10318 05'CYT 23-5.450 6.636 0.201 1.00 0.00 O ATOM 10319 C5'CYT 23-6.820 6.352 0.500 1.00 0.00 C ATOM 10320 C4'CYT 23-6.957 5.504 1. 762 1.00 0.00 C ATOM 10321 04'CYT 23-6.258 4. 265 1.649 1.00 0.00 O ATOM 10322 C1'CYT 23-5.769 3.876 2.947 1.00 0.00 C ATOM 10323 N1 CYT 23-4.313 3.610 2.915 1.00 0.00 N ATOM 10324 C6 CYT 23-3. 467 4.403 2.194 1.00 0.00 C ATOM 10325 C2 CYT 23-3. 844 2.523 3.643 1.00 0. 00 C ATOM 10326 02 CYT 23-4. 625 1.823 4.285 1.00 0.00 O ATOM 10327 N3 CYT 23-2.509 2.261 3.622 1.00 0.00 N ATOM 10328 C4 CYT 23-1.667 3.029 2.920 1.00 0.00 C ATOM 10329 N4 CYT 23-0.366 2.741 2.921 1.00 0.00 N ATOM 10330 C5 CYT 23-2.145 4.150 2.169 1.00 0.00 C ATOM 10331 C2'CYT 23-6.103 5.024 3.906 1.00 0.00 C ATOM 10332 02'CYT 23-7.280 4.738 4.671 1.00 0.00 O ATOM 10333 C3'CYT 23-6.324 6.188 2.955 1.00 0.00 C ATOM 10334 03'CYT 23-7.288 7.076 3.526 1.00 0.00 0 ATOM 10335 1H5'CYT 23-7.264 5.815-0. 338 1.00 0.00 H ATOM 10336 2H5'CYT 23-7. 354 7.291 0.644 1.00 0.00 H ATOM 10337 H4'CYT 23-8. 009 5.309 1.964 1.00 0. 00 H ATOM 10338 H1'CYT 23-6.293 2.977 3.272 1.00 0.00 H ATOM 10339 H6 CYT 23-3.866 5.246 1.630 1.00 0.00 H ATOM 10340 1H4 CYT 23 0.279 3.312 2. 394 1.00 0.00 H ATOM 10341 2H4 CYT 23-0.024 1.951 3.449 1.00 0.00 H ATOM 10342 H5 CYT 23-1.461 4.780 1.601 1.00 0.00 H ATOM 10343 H2'CYT 23-5.252 5.227 4.561 1.00 0.00 H ATOM 10344 H02'CYT 23-7.079 3.986 5.233 1.00 0.00 H ATOM 10345 H3'CYT 23-5. 390 6.688 2.697 1.00 0.00 H ATOM 10346 P GUA 24-7.040 8.666 3.538 1. 00 0.00 P ATOM 10347 O1P GUA 24-8. 158 9.316 2.818 1.00 0.00 O ATOM 10348 02P GUA 24-5.643 8. 925 3.120 1. 00 0.00 O ATOM 10349 05'GUA 24-7.172 9.017 5.102 1.00 0.00 O ATOM 10350 C5'GUA 24-8.431 8.887 5.770 1.00 0.00 C ATOM 10351 C4'GUA 24-8.250 8.535 7.243 1.00 0.00 C ATOM 10352 04'GUA 24-7.548 7. 292 7.406 1.00 0.00 O ATOM. 10353 C1'GUA 24-6.522 7.450 8.403 1.00 0.00 C

ATOM 10354 N9 GUA 24-5. 180 7. 486 7. 797 1. 00 0. 00 N ATOM 10355 C4 GUA 24-3. 994 7. 597 8. 476 1. 00 0. 00 C ATOM 10356 N3 GUA 24-3. 863 7. 687 9. 818 1. 00 0. 00 N ATOM 10357 C2 GUA 24-2. 589 7. 783 10. 194 1. 00 0. 00 C ATOM 10358 N2 GUA 24-2. 282 7. 878 11. 487 1. 00 0. 00 N ATOM 10359 N1 GUA 24-1. 531 7. 790 9. 310 1. 00 0. 00 N ATOM 10360 C6 GUA 24-1. 639 7. 700 7. 928 1. 00 0. 00 C ATOM 10361 06 GUA 24-0. 629 7. 723 7. 227 1. 00 0. 00 O ATOM 10362 C5 GUA 24-2. 994 7. 596 7. 519 1. 00 0. 00 C ATOM 10363 N7 GUA 24-3. 541 7. 483 6. 236 1. 00 0. 00 N ATOM 10364 C8 GUA 24-4. 805 7. 425 6. 494 1. 00 0. 00 C ATOM 10365 C2'GUA 24-6. 837 8. 760 9. 106 1. 00 0. 00 C ATOM 10366 02'GUA 24-7. 805 8. 580 10. 147 1. 00 0. 00 0 ATOM 10367 C3'GUA 24-7. 395 9. 571 7. 957 1. 00 0. 00 C ATOM 10368 03'GUA 24-8. 248 10. 593 8. 483 1. 00 0. 00 0 ATOM 10369 1H5'GUA 24-9. 013 8. 102 5. 286 1. 00 0. 00 H ATOM 10370 2H5'GUA 24-8. 972 9. 830 5. 693 1. 00 0. 00 H ATOM 10371 H4'GUA 24-9. 223 8. 466 7. 726 1. 00 0.00 H ATOM 10372 H1'GUA 24-6. 571 6. 632 9. 121 1. 00 0. 00 H ATOM 10373 1H2 GUA 24-3. 015 7. 877 12. 181 1. 00 0. 00 H ATOM 10374 2H2 GUA 24-1. 317 7. 950 11. 773 1. 00 0. 00 H ATOM 10375 H1 GUA 24-0. 598 7. 860 9. 675 1. 00 0. 00 H ATOM 10376 H8 GUA 24-5. 542 7. 322 5. 697 1. 00 0. 00 H ATOM 10377 H2'GUA 24-5. 922 9. 215 9. 489 1. 00 0. 00 H ATOM 10378 H02'GUA 24-8. 538 9. 172 9. 960 1. 00 0. 00 H ATOM 10379 H3'GUA 24-6. 606 9. 968 7. 316 1. 00 0. 00 H ATOM 10380 P ADE 25-7. 633 12. 001 8. 971 1. 00 0. 00 P ATOM 10381 01P ADE 25-8. 756 12. 914 9. 280 1. 00 0. 00 0 ATOM 10382 02P ADE 25-6. 592 12. 414 8. 004 1. 00 0. 00 0 ATOM 10383 05'ADE 25-6. 907 11. 606 10. 353 1. 00 0. 00 0 ATOM 10384 C5'ADE 25-7. 677 11. 227 11. 499 1. 00 0. 00 C ATOM 10385 C4'ADE 25-6. 792 10. 997 12. 720 1. 00 0. 00 C ATOM 10386 04'ADE 25-5. 819 9. 970 12. 479 1. 00 0. 00 0 ATOM 10387 C1' ADE 25-4. 524 10. 418 12. 918 1. 00 0. 00 C ATOM 10388 N9 ADE 25-3. 650 10. 726 11. 766 1. 00 0. 00 N ATOM 10389 C4 ADE 25-2. 287 10. 925 11. 794 1. 00 0. 00 C ATOM 10390 N3 ADE 25-1. 494 10. 893 12. 883 1. 00 0. 00 N ATOM 10391 C2 ADE 25-0. 224 11. 125 12. 564 1. 00 0. 00 C ATOM 10392 Nl ADE 25 0. 271 11. 363 11. 349 1. 00 0. 00 N ATOM 10393 C6 ADE 25-0. 540 11. 389 10. 277 1. 00 0. 00 C ATOM 10394 N6 ADE 25-0. 025 11. 622 9. 071 1. 00 0. 00 N ATOM 10395 C5 ADE 25-1. 901 11. 159 10. 494 1. 00 0. 00 C ATOM 10396 N7 ADE 25-3. 002 11. 115 9. 633 1. 00 0. 00 N ATOM 10397 C8 ADE 25-3. 964 10. 861 10. 454 1. 00 0. 00 C ATOM 10398 C2'ADE 25-4. 783 11. 657 13. 764 1. 00 0. 00 C ATOM 10399 02'ADE 25-5. 076 11. 314 15. 124 1. 00 0. 00 O ATOM 10400 C3'ADE 25-5. 989 12. 244 13. 060 1. 00 0. 00 C ATOM 10401 03'ADE 25-6. 741 13. 024 13. 995 1. 00 0. 00 0 ATOM 10402 1H5'ADE 25-8. 220 10. 309 11. 275 1. 00 0. 00 H ATOM 10403 2H5'ADE 25-8. 393 12. 018 11. 723 1. 00 0. 00 H ATOM 10404 H4'ADE 25-7. 409 10. 716 13. 572 1. 00 0. 00 H ATOM 10405 H1' ADE 25-4. 060 9. 647 13. 533 1. 00 0. 00 H ATOM 10406 H2 ADE 25 0. 491 11. 124 13. 387 1. 00 0. 00 H ATOM 10407 1H6 ADE 25-0. 626 11. 638 8. 260 1. 00 0. 00 H ATOM 10408 2H6 ADE 25 0. 967 11. 785 8. 967 1. 00 0. 00 H ATOM 10409 H8 ADE 25-4. 991 10. 762 10. 106 1. 00 0. 00 H ATOM 10410 H2'ADE 25-3. 933 12. 342 13. 704 1. 00 0. 00 H ATOM 10411 H02'ADE 25-4. 246 11. 075 15. 543 1. 00 0. 00 H ATOM 10412 H3'ADE 25-5. 706 12. 810 12. 171 1. 00 0. 00 H ATOM 10413 P CYT 26-6. 378 14. 572 14. 249 1. 00 0. 00 P

ATOM 10414 O1P CYT 26-6.085 15.202 12.942 1.00 0.00 0 ATOM 10415 02P CYT 26-7.415 15.152 15.132 1.00 0.00 O ATOM 10416 05'CYT 26-5.004 14.473 15.079 1.00 0.00 0 ATOM 10417 C5'CYT 26-4.995 13.948 16.409 1.00 0. 00 C ATOM 10418 C4'CYT 26-3.576 13.832 16.956 1.00 0.00 C ATOM 10419 04'CYT 26-2.779 12.922 16.184 1.00 0.00 0 ATOM 10420 C1'CYT 26-1.473 13.494 15.968 1.00 0. 00 C ATOM 10421 N1 CYT 26-1.285 13.890 14.556 1.00 0.00 N ATOM 10422 C6 CYT 26-2.334 14.340 13.810 1.00 0.00 C ATOM 10423 C2 CYT 26-0.004 13.802 14.025 1.00 0.00 C ATOM 10424 02 CYT 26 0.927 13.393 14.717 1.00 0.00 0 ATOM 10425 N3 CYT 26 0.184 14.178 12.731 1.00 0.00 N ATOM 10426 C4 CYT 26-0.838 14.622 11.989 1.00 0.00 C ATOM 10427 N4 CYT 26-0.620 14.974 10.722 1.00 0.00 N ATOM 10428 C5 CYT 26-2.156 14.715 12.534 1.00 0.00 C ATOM 10429 C2'CYT 26-1.401 14.709 16.884 1.00 0.00 C ATOM 10430 02'CYT 26-0.967 14.353 18.203 1.00 0.00 O ATOM 10431 C3'CYT 26-2.846 15.161 16.870 1.00 0.00 C ATOM 10432 03'CYT 26-3. 116 15.909 18.059 1.00 0.00 0 ATOM 10433 1H5'CYT 26-5.457 12.960 16.407 1.00 0.00 H ATOM 10434 2H5'CYT 26-5.572 14.609 17.056 1.00 0.00 H ATOM 10435 H4'CYT 26-3.607 13.496 17.991 1.00 0.00 H ATOM 10436 Hl'CYT 26-0.706 12.773 16.253 1.00 0.00 H ATOM 10437 H6 CYT 26-3.330 14.390 14.251 1.00 0.00 H ATOM 104¢38 1H4 CYT 26-1.384 15.307 10.152 1.00 0.00 H ATOM 10439 2H4 CYT 26 0.309 14.906 10.332 1.00 0.00 H ATOM 10440 H5 CYT 26-2.987 15. 092 11.942 1.00 0.00 H ATOM 10441 H2'CYT 26-0.755 15.476 16.447 1.00 0.00 H ATOM 10442 H02'CYT 26-1.549 13.658 18.516 1.00 0.00 H ATOM 10443 H3'CYT 26-3.094 15.708 15.957 1.00 0.00 H ATOM 10444 P CYT 27-3.457 17. 482 17.978 1.00 0.00 P ATOM 10445 01P CYT 27-4.359 17.702 16.825 1.00 0.00 O ATOM 10446 02P CYT 27-3.858 17.940 19.327 1.00 0.00 0 ATOM 10447 05'CYT 27-2.025 18.131 17.627 1.00 0.00 0 ATOM 10448 C5'CYT 27-0. 903 17.915 18. 487 1.00 0.00 C ATOM 10449 C4'CYT 27 0.411 17.912 17.710 1.00 0.00 C ATOM 10450 04'CYT 27 0.373 17.000 16.609 1.00 0.00 O ATOM 10451 C1'CYT 27 1.143 17.541 15.517 1.00 0.00 C ATOM 10452 N1 CYT 27 0.322 17.729 14.298 1.00 0.00 N ATOM 10453 C6 CYT 27-1.041 17.630 14.331 1.00 0.00 C ATOM 10454 C2 CYT 27 0.995 18.026 13.121 1.00 0.00 C ATOM 10455 02 CYT 27 2.221 18. 116 13.117 1.00 0.00 0 ATOM 10456 N3 CYT 27 0.268 18.220 11.989 1.00 0.00 N ATOM 10457 C4 CYT 27-1.066 18.128 12.005 1.00 0.00 C ATOM 10458 N4 CYT 27-1.743 18.325 10.874 1.00 0.00 N ATOM 10459 C5 CYT 27-1.770 17.822 13.212 1.00 0.00 C ATOM 10460 C2'CYT 27 1.695 18.879 16.005 1.00 0.00 C ATOM 10461 02'CYT 27 3.013 18.737 16.549 1.00 0.00 O ATOM 10462 C3'CYT 27 0.687 19.259 17.071 1.00 0.00 C ATOM 10463 03'CYT 27 1.328 20.108 18.030 1.00 0.00 0 ATOM 10464 1H5'CYT 27-1.019 16.954 18.989 1.00 0.00 H ATOM 10465 2H5'CYT 27-0.871 18.706 19.237 1.00 0.00 H ATOM 10466 H4'CYT 27 1.232 17.644 18.373 1.00 0.00 H ATOM 10467 Hl'CYT 27 1.972 16.869 15.294 1.00 0.00 H ATOM 10468 H6 CYT 27-1.544 17.395 15.270 1.00 0.00 H ATOM 10469 1H4 CYT 27-2.751 18.258 10.870 1.00 0.00 H ATOM 10470 2H4 CYT 27-1.248 18.547 10.022 1.00 0.00 H ATOM 10471 H5 CYT 27-2.859 17.751 13.227 1. 00 0.00 H ATOM 10472 H2'CYT 27 1.682 19.610 15. 193 1.00 0.00 H ATOM 10473 H02'CYT 27 2.971 18.055 17. 223 1.00 0.00 H

ATOM 10474 H3'CYT 27-0.212 19.706 16.644 1.00 0.00 H ATOM 10475 P GUA 28 1.615 21.658 17.692 1.00 0.00 P ATOM 10476 O1P GUA 28 0. 526 22.152 16.820 1.00 0.00 0 ATOM 10477 02P GUA 28 1.920 22.359 18.959 1.00 0.00 0 ATOM 10478 05'GUA 28 2.966 21.588 16.815 1.00 0.00 0 ATOM 10479 C5'GUA 28 4.247 21.491 17.449 1.00 0.00 C ATOM 10480 C4'GUA 28 5.370 21.959 16.526 1.00 0.00 C ATOM 10481 04'GUA 28 5.468 21.139 15.351 1.00 0. 00 0 ATOM 10482 C1'GUA 28 5.521 21.976 14.181 1.00 0.00 C ATOM 10483 N9 GUA 28 4.229 21.966 13.465 1.00 0.00 N ATOM 10484 C4 GUA 28 3.994 22.404 12.179 1.00 0.00 C ATOM 10485 N3 GUA 28 4.909 22. 940 11.340 1.00 0.00 N ATOM 10486 C2 GUA 28 4.379 23.269 10.157 1.00 0.00 C ATOM 10487 N2 GUA 28 5.143 23.820 9.214 1.00 0.00 N ATOM 10488 N1 GUA 28 3.050 23.080 9.835 1.00 0.00 N ATOM 10489 C6 GUA 28 2.093 22.534 10.679 1.00 0.00 C ATOM 10490 06 GUA 28 0.934 22.406 10.296 1.00 0.00 0 ATOM 10491 C5 GUA 28 2.646 22.183 11.937 1.00 0.00 C ATOM 10492 N7 GUA 28 2.032 21.612 13.055 1.00 0.00 N ATOM 10493 C8 GUA 28 3.018 21.526 13.881 1.00 0.00 C ATOM 10494 C2'GUA 28 5.855 23.366 14.696 1.00 0.00 C ATOM 10495 02'GUA 28 7.266 23.534 14.884 1.00 0.00 0 ATOM 10496 C3'GUA 28 5.108 23.369 16.013 1.00 0.00 C ATOM 10497 03'GUA 28 5.735 24.303 16.897 1.00 0.00 0 ATOM 10498 1H5'GUA 28 4.427 20.453 17.731 1.00 0.00 H ATOM 10499 2H5'GUA 28 4.246 22.109 18.348 1.00 0.00 H ATOM 10500 H4'GUA 28 6.318 21.935 17.061 1.00 0.00 H ATOM 10501 Hl'GUA 28 6.313 21. 629 13.517 1.00 0.00 H ATOM 10502 1H2 GUA 28 6.122 23.989 9.393 1.00 0.00 H ATOM 10503 2H2 GUA 28 4.742 24.069 8.320 1.00 0.00 H ATOM 10504 H1 GUA 28 2.727 23.350 8.917 1.00 0.00 H ATOM 10505 H8 GUA 28 2. 881 21.120 14.882 1.00 0.00 H ATOM 10506 H2'GUA 28 5.452 24.127 14.023 1.00 0.00 H ATOM 10507 H02'GUA 28 7.574 22.789 15.406 1.00 0.00 H ATOM 10508 H3'GUA 28 4.043 23.566 15.878 1.00 0.00 H ATOM 10509 P CYT 29 5.190 25.814 17.006 1.00 0.00 P ATOM 10510 01P CYT 29 3.724 25.765 17.205 1.00 0.00 0 ATOM 10511 02P CYT 29 6.041 26.545 17.971 1.00 0.00 0 ATOM 10512 05'CYT 29 5.479 26.398 15.533 1.00 0.00 0 ATOM 10513 C5'CYT 29 6. 814 26.703 15.117 1.00 0.00 C ATOM 10514 C4'CYT 29 6.860 27.127 13.651 1.00 0.00 C ATOM 10515 04'CYT 29 6.395 26.084 12.785 1.00 0.00 0 ATOM 10516 Cl'CYT 29 5.525 26.640 11.780 1.00 0.00 C ATOM 10517 N1 CYT 29 4.124 26.200 11.976 1.00 0.00 N ATOM 10518 C6 CYT 29 3.676 25. 802 13.204 1.00 0.00 C ATOM 10519 C2 CYT 29 3.292 26.186 10.864 1.00 0.00 C ATOM 10520 02 CYT 29 3.712 26.558 9.769 1.00 0.00 0 ATOM 10521 N3 CYT 29 2. 009 25.759 11.024 1.00 0.00 N ATOM 10522 C4 CYT 29 1.559 25. 363 12.221 1. 00 0. 00 C ATOM 10523 N4 CYT 29 0.301 24.941 12.339 1.00 0.00 N ATOM 10524 C5 CYT 29 2.409 25. 379 13.370 1.00 0.00 C ATOM 10525 C2'CYT 29 5.653 28.154 11.909 1.00 0.00 C ATOM 10526 02'CYT 29 6.730 28.660 11.111 1.00 0.00 0 ATOM 10527 C3'CYT 29 5.933 28. 303 13.390 1.00 0.00 C ATOM 10528 03'CYT 29 6. 661 29.517 13.603 1.00 0.00 0 ATOM 10529 1H5'CYT 29 7.440 25.821 15.252 1.00 0.00 H ATOM 10530 2H5'CYT 29 7.202 27. 513 15.734 1.00 0.00 H ATOM 10531 H4'CYT 29 7.880 27. 395 13.378 1.00 0.00 H ATOM 10532 Hl'CYT 29 5. 869 26.330 10.793 1. 00 0.00 H ATOM 10533 H6 CYT 29 4.349 25. 833 14. 060 1.00 0. 00 H

ATOM 10534 1H4 CYT 29-0.047 24.635 13.236 1.00 0.00 H ATOM 10535 2H4 CYT 29-0.305 24.926 11.530 1.00 0.00 H ATOM 10536 H5 CYT 29 2.045 25.059 14.346 1.00 0.00 H ATOM 10537 H2'CYT 29 4.709 28.637 11.648 1.00 0.00 H ATOM 10538 H02'CYT 29 6.451 28.617 10.194 1.00 0.00 H ATOM 10539 H3'CYT 29 5.021 28.248 13.986 1.00 0.00 H ATOM 10540 P CYT 30 5.883 30.891 13.916 1.00 0.00 P ATOM 10541 01P CYT 30 6.890 31.951 14.147 1.00 0.00 0 ATOM 10542 02P CYT 30 4.852 30.618 14.943 1.00 0.00 0 ATOM 10543 05'CYT 30 5.136 31.198 12.523 1.00 0.00 O ATOM 10544 C5'CYT 30 5.872 31.667 11.388 1.00 0.00 C ATOM 10545 C4'CYT 30 5.017 31.659 10.124 1.00 0.00 C ATOM 10546 04'CYT 30 4.529 30.347 9.824 1.00 0.00 0 ATOM 10547 Cl'CYT 30 3.185 30.444 9.319 1.00 0.00 C ATOM 10548 N1 CYT 30 2.221 29.766 10.216 1.00 0.00 N ATOM 10549 C6 CYT 30 2.445 29.683 11.562 1.00 0.00 C ATOM 10550 C2 CYT 30 1.087 29.214 9.637 1.00 0.00 C ATOM 10551 02 CYT 30 0.901 29.310 8.425 1.00 0.00 0 ATOM 10552 N3 CYT 30 0.195 28.578 10.442 1.00 0.00 N ATOM 10553 C4 CYT 30 0.401 28. 486 11.762 1.00 0.00 C ATOM 10554 N4 CYT 30-0.494 27.854 12.520 1.00 0.00 N ATOM 10555 C5 CYT 30 1.566 29.055 12.366 1.00 0.00 C ATOM 10556 C2'CYT 30 2.884 31.937 9.208 1.00 0.00 C ATOM 10557 02'CYT 30 3.236 32.447 7.916 1.00 0.00 0 ATOM 10558 C3'CYT 30 3.771 32.510 10.294 1.00 0.00 C ATOM 10559 03'CYT 30 4.041 33.901 10.087 1.00 0.00 O ATOM 10560 1H5'CYT 30 6.739 31.024 11.234 1.00 0.00 H ATOM 10561 2H5'CYT 30 6.212 32.684 11.580 1.00 0.00 H ATOM 10562 H4'CYT 30 5.601 32.028 9.282 1.00 0.00 H ATOM 10563 H1'CYT 30 3.139 29.992 8.328 1.00 0.00 H ATOM 10564 H6 CYT 30 3.341 30.132 11.989 1.00 0.00 H ATOM 10565 1H4 CYT 30-0.348 27.778 13.517 1.00 0.00 H ATOM 10566 2H4 CYT 30-1.322 27.457 12.099 1.00 0.00 H ATOM 10567 H5 CYT 30 1.738 28. 982 13.440 1.00 0.00 H ATOM 10568 H2'CYT 30 1.831 32.130 9.434 1.00 0.00 H ATOM 10569 H02'CYT 30 4.163 32.241 7.772 1.00 0.00 H ATOM 10570 H3'CYT 30 3.323 32.334 11.276 1.00 0.00 H ATOM 10571 H03'CYT 30 3.209 34.370 10.179 1.00 0.00 H TER ATOM 10572 05'GUA 1 4.582 22.111-4. 248 1.00 0.00 0 ATOM 10573 C5'GUA 1 3.572 22.199-5. 256 1.00 0.00 C ATOM 10574 C4'GUA 1 3.481 20.914-6. 075 1.00 0.00 C ATOM 10575 04'GUA 1 4.734 20.604-6. 706 1.00 0.00 0 ATOM 10576 C1'GUA 1 5.066 19.225-6. 464 1.00 0.00 C ATOM 10577 N9 GUA 1 6.133 19.102-5. 450 1.00 0.00 N ATOM 10578 C4 GUA 1 6.931 18.002-5. 227 1.00 0.00 C ATOM 10579 N3 GUA 1 6.877 16.832-5. 903 1.00 0.00 N ATOM 10580 C2 GUA 1 7.777 15.950-5. 457 1.00 0.00 C ATOM 10581 N2 GUA 1 7.854 14.739-6. 008 1.00 0.00 N ATOM 10582 N1 GUA 1 8.658 16.210-4. 427 1.00 0.00 N ATOM 10583 C6 GUA 1 8.733 17.401-3. 718 1.00 0.00 C ATOM 10584 06 GUA 1 9.556 17.531-2. 814 1.00 0.00 0 ATOM 10585 C5 GUA 1 7.779 18.344-4. 184 1.00 0.00 C ATOM 10586 N7 GUA 1 7.524 19.647-3. 749 1.00 0.00 N ATOM 10587 C8 GUA 1 6.564 20. 003-4. 533 1.00 0.00 C ATOM 10588 C2'GUA 1 3.779 18.578-5. 982 1.00 0.00 C ATOM 10589 02'GUA 1 2.943 18.186-7. 078 1.00 0.00 O ATOM 10590 C3'GUA 1 3.170 19.715-5. 188 1.00 0.00 C ATOM 10591 03'GUA 1 1.752 19.535-5. 136 1.00 0.00 0 ATOM 10592 H5'GUA 1 4.593 22.950-3. 781 1.00 0.00 H

ATOM 10593 1H5'GUA 1 3.806 23.030-5. 923 1.00 0.00 H ATOM 10594 2H5'GUA 1 2.609 22.386-4. 779 1.00 0.00 H ATOM 10595 H4'GUA 1 2.709 21.016-6. 836 1.00 0.00 H ATOM 10596 Hl'GUA 1 5.387 18.756-7. 395 1.00 0.00 H ATOM 10597 1H2 GUA 1 7.232 14.488-6. 763 1.00 0.00 H ATOM 10598 2H2 GUA 1 8.535 14.073-5. 672 1.00 0.00 H ATOM 10599 H1 GUA 1 9.308 15.492-4. 150 1.00 0.00 H ATOM 10600 H8 GUA 1 6.110 20.990-4. 458 1.00 0.00 H ATOM 10601 H2'GUA 1 4.000 17.729-5. 330 1.00 0.00 H ATOM 10602 H02'GUA 1 3.339 17.406-7. 473 1.00 0.00 H ATOM 10603 H3'GUA 1 3.620 19.808-4. 198 1.00 0.00 H ATOM 10604 P GUA 2 1.081 18.670-3. 955 1. 00 0.00 P ATOM 10605 01P GUA 2-0.376 18.596-4. 205 1.00 0.00 0 ATOM 10606 02P GUA 2 1.581 19.185-2. 661 1.00 0.00 0 ATOM 10607 05'GUA 2 1.709 17.206-4. 190 1.00 0.00 0 ATOM 10608 C5'GUA 2 1.344 16.435-5. 338 1.00 0.00 C ATOM 10609 C4'GUA 2 2.209 15.186-5. 476 1.00 0.00 C ATOM 10610 04'GUA 2 3.600 15.508-5. 579 1.00 0.00 O ATOM 10611 C1'GUA 2 4.374 14.508-4. 886 1.00 0.00 C ATOM 10612 N9 GUA 2 5.148 15.101-3. 776 1.00 0.00 N ATOM 10613 C4 GUA 2 6.227 14.533-3. 132 1.00 0.00 C ATOM 10614 N3 GUA 2 6.756 13.316-3. 394 1.00 0.00 N ATOM 10615 C2 GUA 2 7.800 13.039-2. 607 1.00 0.00 C ATOM 10616 N2 GUA 2 8.436 11.874-2. 730 1.00 0.00 N ATOM 10617 N1 GUA 2 8.281 13.899-1. 640 1.00 0.00 N ATOM 10618 C6 GUA 2 7.756 15. 152-1. 353 1.00 0.00 C ATOM 10619 06 GUA 2 8.260 15.843-0. 472 1.00 0.00 0 ATOM 10620 C5 GUA 2 6.644 15.455-2. 184 1.00 0.00 C ATOM 10621 N7 GUA 2 5.839 16.597-2. 221 1.00 0.00 N ATOM 10622 C8 GUA 2 5.008 16.305-3. 164 1.00 0.00 C ATOM 10623 C2'GUA 2 3.372 13.475-4. 370 1.00 0.00 C ATOM 10624 02'GUA 2 3.202 12.397-5. 300 1.00 0.00 0 ATOM 10625 C3'GUA 2 2.113 14.307-4. 245 1.00 0.00 C ATOM 10626 03'GUA 2 0.973 13.453-4. 382 1.00 0.00 0 ATOM 10627 1H5'GUA 2 1.462 17.049-6. 232 1.00 0.00 H ATOM 10628 2H5'GUA 2 0.300 16.136-5. 247 1.00 0.00 H ATOM 10629 H4'GUA 2 1.904 14.622-6. 356 1.00 0.00 H ATOM 10630 H1'GUA 2 5.056 14.029-5. 589 1.00 0.00 H ATOM 10631 1H2 GUA 2 8.128 11.202-3. 418 1.00 0.00 H ATOM 10632 2H2 GUA 2 9.227 11.665-2. 138 1.00 0.00 H ATOM 10633 H1 GUA 2 9.080 13.617-1. 091 1.00 0.00 H ATOM 10634 H8 GUA 2 4.222 17.001-3. 458 1.00 0.00 H ATOM 10635 H2'GUA 2 3.683 13.104-3. 392 1.00 0.00 H ATOM 10636 H02'GUA 2 3.981 11.840-5. 236 1.00 0.00 H ATOM 10637 H3'GUA 2 2.097 14.888-3. 322 1.00 0.00 H ATOM 10638 P CYT 3 0.342 12.720-3. 096 1.00 0.00 P ATOM 10639 01P CYT 3-0.921 12.066-3. 508 1.00 0.00 O ATOM 10640 02P CYT 3 0.341 13.679-1. 968 1.00 0.00 O ATOM 10641 05'CYT 3 1.427 11.574-2. 780 1.00 0.00 0 ATOM 10642 C5'CYT 3 1.450 10.363-3. 541 1.00 0.00 C ATOM 10643 C4'CYT 3 2.531 9.407-3. 046 1.00 0.00 C ATOM 10644 04'CYT 3 3.848 9.950-3. 226 1.00 0.00 0 ATOM 10645 C1'CYT 3 4.632 9.705-2. 040 1.00 0.00 C ATOM 10646 N1 CYT 3 4.875 10.958-1. 289 1.00 0.00 N ATOM 10647 C6 CYT 3 3.944 11.956-1. 270 1.00 0.00 C ATOM 10648 C2 CYT 3 6.079 11.079-0. 606 1.00 0.00 C ATOM 10649 02 CYT 3 6.903 10.166-0. 632 1.00 0. 00 O ATOM 10650 N3 CYT 3 6. 312 12.227 0.088 1.00 0.00 N ATOM 10651 C4 CYT 3 5.406 13.212 0.114 1.00 0. 00 C ATOM 10652 N4 CYT 3 5.669 14.326 0.797 1.00 0.00 N

ATOM 10653 C5 CYT 3 4.166 13.090-0. 585 1.00 0.00 C ATOM 10654 C2'CYT 3 3.817 8.721-1. 211 1.00 0.00 C ATOM 10655 02'CYT 3 4.055 7.367-1. 614 1.00 0.00 0 ATOM 10656 C3'CYT 3 2.412 9.169-1. 550 1.00 0.00 C ATOM 10657 03'CYT 3 1.507 8.086-1. 320 1.00 0.00 0 ATOM 10658 1H5'CYT 3 1.638 10.602-4. 588 1.00 0.00 H ATOM 10659 2H5'CYT 3 0.479 9.874-3. 457 1.00 0.00 H ATOM 10660 H4'CYT 3 2.456 8.459-3. 576 1.00 0.00 H ATOM 10661 H1'CYT 3 5.583 9.250-2. 317 1.00 0.00 H ATOM 10662 H6 CYT 3 3.010 11.834-1. 819 1.00 0.00 H ATOM 10663 1H4 CYT 3 4.994 15.077 0.817 1.00 0.00 H ATOM 10664 2H4 CYT 3 6.543 14.419 1.293 1.00 0.00 H ATOM 10665 H5 CYT 3 3.422 13.885-0. 560 1.00 0.00 H ATOM 10666 H2'CYT 3 4.020 8.860-0. 147 1.00 0.00 H ATOM 10667 H02'CYT 3 3.411 6.818-1. 162 1.00 0.00 H ATOM 10668 H3'CYT 3 2.133 10.077-1. 010 1.00 0.00 H ATOM 10669 P GUA 4 0.625 8.037 0.027 1.00 0.00 P ATOM 10670 01P GUA 4 0.113 9.400 0.297 1.00 0.00 0 ATOM 10671 02P GUA 4-0.320 6.902-0. 079 1.00 0.00 O ATOM 10672 05'GUA 4 1.722 7.680 1.149 1.00 0.00 0 ATOM 10673 C5'GUA 4 2.340 6.390 1.173 1.00 0.00 C ATOM 10674 C4'GUA 4 3.672 6.411 1.917 1.00 0.00 C ATOM 10675 04'GUA 4 4.569 7.392 1.383 1.00 0.00 0 ATOM 10676 C1'GUA 4 5.328 7.976 2.463 1.00 0.00 C ATOM 10677 N9 GUA 4 5.050 9.419 2.609 1.00 0.00 N ATOM 10678 C4 GUA 4 5.794 10.322 3.333 1.00 0.00 C ATOM 10679 N3 GUA 4 6.928 10.046 4.015 1.00 0. 00 N ATOM 10680 C2 GUA 4 7. 424 11.123 4.628 1.00 0.00 C ATOM 10681 N2 GUA 4 8.542 11.024 5.346 1.00 0.00 N ATOM 10682 N1 GUA 4 6.842 12.374 4.567 1.00 0.00 N ATOM 10683 C6 GUA 4 5.680 12.683 3.872 1.00 0.00 C ATOM 10684 06 GUA 4 5.244 13.833 3.878 1.00 0.00 O ATOM 10685 C5 GUA 4 5.144 11.541 3.219 1.00 0.00 C ATOM 10686 N7 GUA 4 3.999 11.416 2.427 1.00 0.00 N ATOM 10687 C8 GUA 4 4.026 10.162 2.122 1.00 0.00 C ATOM 10688 C2'GUA 4 4.914 7.221 3.723 1.00 0.00 C ATOM 10689 02'GUA 4 5.751 6.081 3.951 1.00 0.00 O ATOM 10690 C3'GUA 4 3.499 6.816 3.368 1.00 0.00 C ATOM 10691 03'GUA 4 3.137 5.664 4.135 1.00 0.00 0 ATOM 10692 1H5'GUA 4 2.512 6.059 0.148 1.00 0.00 H ATOM 10693 2H5'GUA 4 1.669 5.684 1.664 1.00 0.00 H ATOM 10694 H4'GUA 4 4.140 5.429 1.863 1.00 0. 00 H ATOM 10695 H1'GUA 4 6.393 7.825 2.282 1.00 0.00 H ATOM 10696 1H2 GUA 4 9.013 10.135 5.425 1.00 0.00 H ATOM 10697 2H2 GUA 4 8.913 11. 836 5.817 1.00 0.00 H ATOM 10698 H1 GUA 4 7.272 13.137 5.069 1.00 0. 00 H ATOM 10699 H8 GUA 4 3.248 9.716 1.504 1.00 0.00 H ATOM 10700 H2'GUA 4 4.916 7.892 4.586 1.00 0. 00 H ATOM 10701 H02'GUA 4 5.700 5.528 3.168 1.00 0.00 H ATOM 10702 H3'GUA 4 2.795 7.642 3.484 1.00 0.00 H ATOM 10703 P CYT 5 2.661 5.821 5.666 1.00 0.00 P ATOM 10704 01P CYT 5 2.138 4.515 6.125 1.00 0.00 O ATOM 10705 02P CYT 5 1. 816 7.032 5.769 1.00 0.00 0 ATOM 10706 05'CYT 5 4.046 6.109 6.434 1.00 0.00 O ATOM 10707 C5'CYT 5 5.033 5.082 6.562 1.00 0.00 C ATOM 10708 C4'CYT 5 6.243 5.564 7.356 1.00 0.00 C ATOM 10709 04'CYT 5 6.896 6.664 6.711 1.00 0.00 O ATOM 10710 Cl'CYT 5 7.300 7.633 7.698 1.00 0.00 C ATOM 10711 N1 CYT 5 6. 577 8.913 7.524 1.00 0. 00 N ATOM 10712 C6 CYT 5 5.304 8.940 7.034 1.00 0.00 C

ATOM 10713 C2 CYT 5 7.240 10.081 7.882 1.00 0.00 C ATOM 10714 02 CYT 5 8.388 10.033 8.321 1.00 0.00 O ATOM 10715 N3 CYT 5 6.587 11.265 7.730 1.00 0.00 N ATOM 10716 C4 CYT 5 5. 338 11.306 7.250 1.00 0.00 C ATOM 10717 N4 CYT 5 4.729 12.484 7. il5 1.00 0.00 N ATOM 10718 C5 CYT 5 4.651 10.107 6.881 1.00 0.00 C ATOM 10719 C2'CYT 5 6.989 7.010 9.057 1.00 0.00 C ATOM 10720 02'CYT 5 8.110 6.277 9.567 1.00 0.00 0 ATOM 10721 C3'CYT 5 5.829 6.096 8.715 1.00 0.00 C ATOM 10722 03'CYT 5 5.804 5.006 9.642 1.00 0.00 0 ATOM 10723 1H5'CYT 5 5.359 4.774 5.569 1.00 0.00 H ATOM 10724 2H5'CYT 5 4.592 4.226 7.074 1.00 0.00 H ATOM 10725 H4'CYT 5 6.952 4.747 7.481 1.00 0.00 H ATOM 10726 H1'CYT 5 8.373 7.808 7.616 1.00 0.00 H ATOM 10727 H6 CYT 5 4.810 8.007 6.763 1.00 0.00 H ATOM 10728 1H4 CYT 5 5.211 13.334 7.374 1.00 0.00 H ATOM 10729 2H4 CYT 5 3.787 12.528 6.755 1.00 0.00 H ATOM 10730 H5 CYT 5 3.635 10.135 6.492 1.00 0.00 H ATOM 10731 H2'CYT 5 6.671 7.784 9.760 1.00 0.00 H ATOM 10732 H02'CYT 5 8.383 5.661 8.884 1.00 0.00 H ATOM 10733 H3'CYT 5 4. 882 6.636 8.675 1.00 0.00 H ATOM 10734 P URI 6 4.897 5.078 10.971 1.00 0.00 P ATOM 10735 01P URI 6 3.629 5.763 10.632 1.00 0.00 O ATOM 10736 02P URI 6 4.867 3.732 11.586 1.00 0.00 0 ATOM 10737 05'URI 6 5.754 6.050 11.925 1.00 0.00 O ATOM 10738 C5'URI 6 7.029 5.637 12.423 1.00 0.00 C ATOM 10739 C4'URI 6 7.772 6.789 13.094 1.00 0.00 C ATOM 10740 04'URI 6 7.971 7.887 12.192 1.00 0.00 0 ATOM 10741 C1'URI 6 7.713 9.127 12.883 1.00 0.00 C ATOM 10742 N1 URI 6 6.488 9.787 12.376 1.00 0.00 N ATOM 10743 C6 URI 6 5.500 9.067 11.757 1.00 0.00 C ATOM 10744 C2 URI 6 6.380 11.156 12.551 1.00 0.00 C ATOM 10745 02 URI 6 7.256 11.818 13.106 1.00 0.00 O ATOM 10746 N3 URI 6 5.226 11.743 12. 066 1.00 0.00 N ATOM 10747 C4 URI 6 4.185 11.091 11.429 1.00 0.00 C ATOM 10748 04 URI 6 3.207 11.716 11.029 1.00 0.00 O ATOM 10749 C5 URI 6 4.378 9.666 11.290 1.00 0.00 C ATOM 10750 C2'URI 6 7.568 8.756 14.353 1.00 0.00 C ATOM 10751 02'URI 6 8.837 8.733 15.018 1.00 0.00 0 ATOM 10752 C3'URI 6 6.968 7.370 14.244 1.00 0.00 C ATOM 10753 03'URI 6 7.270 6.637 15.435 1.00 0.00 0 ATOM 10754 1H5'URI 6 7.631 5.261 11.595 1. 00 0.00 H ATOM 10755 2H5'URI 6 6.884 4.837 13.150 1.00 0.00 H ATOM 10756 H4'URI 6 8.737 6.442 13.458 1.00 0.00 H ATOM 10757 H1'URI 6 8.565 9.795 12.760 1.00 0.00 H ATOM 10758 H6 URI 6 5.618 7.990 11.638 1.00 0.00 H ATOM 10759 H3 URI 6 5.133 12.741 12.191 1.00 0.00 H ATOM 10760 H5 URI 6 3.609 9.065 10.805 1.00 0.00 H ATOM 10761 H2'URI 6 6.874 9.438 14.850 1.00 0.00 H ATOM 10762 H02'URI 6 9.391 8.103 14.552 1.00 0.00 H ATOM 10763 H3'URI 6 5.899 7.403 14.026 1.00 0.00 H ATOM 10764 P CYT 7 6.217 6.587 16.654 1.00 0.00 P ATOM 10765 01P CYT 7 6.758 5.688 17.697 1.00 0.00 0 ATOM 10766 02P CYT 7 4.870 6.339 16.092 1.00 0.00 O ATOM 10767 05'CYT 7 6.257 8.096 17.214 1.00 0.00 0 ATOM 10768 C5'CYT 7 7.479 8.655 17.705 1.00 0.00 C ATOM 10769 C4'CYT 7 7.412 10.178 17.777 1. 00 0.00 C ATOM 10770 04'CYT 7 7.053 10.754 16.514 1.00 0.00 0 ATOM 10771 C1'CYT 7 6.170 11.873 16.735 1.00 0.00 C ATOM 10772 N1 CYT 7 4. 819 11.629 16.178 1.00 0.00 N

ATOM 10773 C6 CYT 7 4.460 10.404 15.691 1.00 0.00 C ATOM 10774 C2 CYT 7 3.932 12.695 16.177 1.00 0.00 C ATOM 10775 02 CYT 7 4.278 13.786 16.624 1.00 0.00 0 ATOM 10776 N3 CYT 7 2.684 12.498 15.677 1.00 0.00 N ATOM 10777 C4 CYT 7 2.317 11.305 15.196 1.00 0.00 C ATOM 10778 N4 CYT 7 1.084 11.149 14.718 1.00 0.00 N ATOM 10779 C5 CYT 7 3.226 10.200 15.192 1.00 0.00 C ATOM 10780 C2'CYT 7 6.105 12.061 18.247 1.00 0.00 C ATOM 10781 02'CYT 7 7.136 12.942 18.710 1.00 0.00 0 ATOM 10782 C3'CYT 7 6.324 10.644 18.727 1.00 0.00 C ATOM 10783 03'CYT 7 6.850 10.689 20.056 1.00 0.00 0 ATOM 10784 1H5'CYT 7 8.294 8.368 17.041 1.00 0.00 H ATOM 10785 2H5'CYT 7 7.676 8.261 18.702 1.00 0.00 H ATOM 10786 H4'CYT 7 8.374 10.576 18.095 1.00 0.00 H ATOM 10787 Hl'CYT 7 6.595 12.767 16.279 1.00 0.00 H ATOM 10788 H6 CYT 7 5.174 9.583 15.715 1.00 0.00 H ATOM 10789 1H4 CYT 7 0.792 10.254 14.354 1.00 0.00 H ATOM 10790 2H4 CYT 7 0.439 11.928 14.724 1.00 0.00 H ATOM 10791 H5 CYT 7 2.933 9.229 14.796 1.00 0.00 H ATOM 10792 H2'CYT 7 5.115 12.418 18.545 1.00 0.00 H ATOM 10793 H02'CYT 7 7.422 12.620 19.568 1.00 0.00 H ATOM 10794 H3'CYT 7 5.419 10.039 18.648 1.00 0.00 H ATOM 10795 P ADE 8 5.853 10.700 21.321 1.00 0.00 P ATOM 10796 01P ADE 8 6.647 10.994 22.535 1.00 0.00 0 ATOM 10797 02P ADE 8 5.018 9.480 21.262 1.00 0.00 0 ATOM 10798 05'ADE 8 4.908 11.969 21.015 1.00 0.00 0 ATOM 10799 C5'ADE 8 5.410 13.304 21.137 1.00 0.00 C ATOM 10800 C4'ADE 8 4.298 14.337 20.980 1.00 0.00 C ATOM 10801 04'ADE 8 3.667 14.251 19.692 1.00 0.00 0 ATOM 10802 C1'ADE 8 2.236 14.315 19.856 1.00 0.00 C ATOM 10803 N9 ADE 8 1.609 12.999 19.608 1.00 0.00 N ATOM 10804 C4 ADE 8 0.260 12.734 19.468 1.00 0.00 C ATOM 10805 N3 ADE 8-0.747 13.632 19.518 1.00 0.00 N ATOM 10806 C2 ADE 8-1.931 13.044 19.345 1.00 0.00 C ATOM 10807 N1 ADE 8-2.163 11.746 19.145 1.00 0.00 N ATOM 10808 C6 ADE 8-1.144 10.871 19.099 1.00 0.00 C ATOM 10809 N6 ADE 8-1.400 9.578 18.902 1.00 0.00 N ATOM 10810 C5 ADE 8 0.150 11.377 19.268 1.00 0.00 C ATOM 10811 N7 ADE 8 1.409 10.768 19.277 1.00 0.00 N ATOM 10812 C8 ADE 8 2.186 11.778 19.478 1.00 0.00 C ATOM 10813 C2'ADE 8 2.012 14.766 21.292 1.00 0.00 C ATOM 10814 02'ADE 8 2.076 16.193 21.413 1.00 0.00 O ATOM 10815 C3'ADE 8 3.178 14.091 21.976 1.00 0.00 C ATOM 10816 03'ADE 8 3.472 14.779 23.195 1.00 0.00 0 ATOM 10817 1H5'ADE 8 6.165 13.475 20. 371 1.00 0.00 H ATOM 10818 2H5'ADE 8 5.868 13.422 22.119 1.00 0.00 H ATOM 10819 H4'ADE 8 4.701 15.339 21.119 1.00 0.00 H ATOM 10820 H1'ADE 8 1.823 15.053 19.174 1.00 0.00 H ATOM 10821 H2 ADE 8-2.808 13.693 19.369 1.00 0.00 H ATOM 10822 1H6 ADE 8-2.353 9.265 18.786 1.00 0.00 H ATOM 10823 2H6 ADE 8-0.642 8.912 18.870 1.00 0.00 H ATOM 10824 H8 ADE 8 3. 266 11.654 19.544 1.00 0.00 H ATOM 10825 H2'ADE 8 1.065 14.376 21.671 1.00 0.00 H ATOM 10826 H02'ADE 8 2.180 16.395 22.345 1.00 0.00 H ATOM 10827 H3'ADE 8 2.996 13.030 22.127 1. 00 0.00 H ATOM 10828 P ADE 9 4.257 14.027 24.386 1.00 0.00 P ATOM 10829 01P ADE 9 3.891 14.678 25.663 1.00 0.00 0 ATOM 10830 02P ADE 9 5.681 13.907 24.001 1.00 0. 00 0 ATOM 10831 05'ADE 9 3.602 12.552 24.366 1.00 0.00 O ATOM 10832 C5'ADE 9 3.968 11.575 25.348 1.00 0.00 C

ATOM 10833 C4'ADE 9 3.187 10.269 25.180 1.00 0. 00 C ATOM 10834 04'ADE 9 1.776 10.499 25.189 1.00 0.00 O ATOM 10835 Cl'ADE 9 1.251 10.388 23.855 1. 00 0.00 C ATOM 10836 N9 ADE 9 0.424 11.564 23.524 1. 00 0.00 N ATOM 10837 C4 ADE 9-0.884 11.561 23.098 1.00 0.00 C ATOM 10838 N3 ADE 9-1.652 10.478 22.888 1.00 0.00 N ATOM 10839 C2 ADE 9-2. 868 10.822 22.482 1.00 0.00 C ATOM 10840 N1 ADE 9-3.336 12.055 22.284 1.00 0.00 N ATOM 10841 C6 ADE 9-2.549 13.122 22.500 1.00 0.00 C ATOM 10842 N6 ADE 9-3.033 14.347 22.297 1.00 0.00 N ATOM 10843 C5 ADE 9-1.243 12.879 22.934 1.00 0.00 C ATOM 10844 N7 ADE 9-0.180 13.727 23.250 1.00 0.00 N ATOM 10845 C8 ADE 9 0.735 12.880 23.579 1.00 0.00 C ATOM 10846 C2'ADE 9 2.461 10.280 22.930 1.00 0.00 C ATOM 10847 02'ADE 9 2.175 9.485 21.774 1.00 0.00 0 ATOM 10848 C3'ADE 9 3.475 9.609 23.834 1.00 0.00 C ATOM 10849 03'ADE 9 3.147 8.210 23.902 1.00 0.00 0 ATOM 10850 1H5'ADE 9 3.768 11.980 26.340 1.00 0.00 H ATOM 10851 2H5'ADE 9 5.034 11.365 25.260 1.00 0.00 H ATOM 10852 H4'ADE 9 3.445 9.589 25.989 1.00 0.00 H ATOM 10853 H1'ADE 9 0.648 9.482 23.774 1.00 0.00 H ATOM 10854 H2 ADE 9-3.561 10.008 22.298 1.00 0.00 H ATOM 10855 1H6 ADE 9-2.448 15.154 22.457 1.00 0.00 H ATOM 10856 2H6 ADE 9-3.985 14.468 21.982 1.00 0.00 H ATOM 10857 H8 ADE 9 1.721 13.210 23.893 1.00 0.00 H ATOM 10858 H2'ADE 9 2.812 11.273 22.651 1.00 0.00 H ATOM 10859 H02'ADE 9 3.012 9.303 21.339 1.00 0.00 H ATOM 10860 H3'ADE 9 4.499 9.781 23.503 1.00 0.00 H ATOM 10861 P URI 10 3.652 7.276 25.117 1.00 0.00 P ATOM 10862 01P URI 10 3.397 5.864 24.753 1.00 0.00 O ATOM 10863 02P URI 10 5.015 7.706 25.501 1.00 0.00 O ATOM 10864 05'URI 10 2.640 7.687 26.299 1.00 0.00 0 ATOM 10865 C5'URI 10 2.195 6.729 27.263 1.00 0.00 C ATOM 10866 C4'URI 10 0.676 6.576 27.227 1.00 0.00 C ATOM 10867 04'URI 10 0.238 5.972 25.998 1.00 0.00 O ATOM 10868 C1'URI 10-0.339 4.683 26.267 1.00 0.00 C ATOM 10869 N1 URI 10 0.077 3.682 25.257 1.00 0.00 N ATOM 10870 C6 URI 10 1.092 3.949 24.376 1.00 0.00 C ATOM 10871 C2 URI 10-0.594 2.470 25.237 1.00 0.00 C ATOM 10872 02 URI 10-1.511 2.212 26.015 1. 00 0.00 0 ATOM 10873 N3 URI 10-0.175 1.560 24.284 1.00 0.00 N ATOM 10874 C4 URI 10 0.839 1.749 23.361 1.00 0.00 C ATOM 10875 04 URI 10 1.126 0. 866 22.557 1.00 0.00 0 ATOM 10876 C5 URI 10 1.483 3.040 23. 452 1. 00 0. 00 C ATOM 10877 C2'URI 10 0.151 4.302 27.657 1.00 0.00 C ATOM 10878 02'URI 10-0.750 3.402 28.313 1.00 0.00 O ATOM 10879 C3'URI 10 0.185 5.657 28.338 1.00 0.00 C ATOM 10880 03'URI 10-1.156 6.036 28.671 1.00 0.00 0 ATOM 10881 1H5'URI 10 2.495 7.062 28.256 1.00 0.00 H ATOM 10882 2H5'URI 10 2.659 5.764 27.055 1.00 0.00 H ATOM 10883 H4'URI 10 0.211 7.554 27.330 1.00 0.00 H ATOM 10884 H1'URI 10-1.427 4.763 26.275 1.00 0.00 H ATOM 10885 H6 URI 10 1.593 4. 916 24.415 1.00 0.00 H ATOM 10886 H3 URI 10-0.655 0.672 24.259 1.00 0.00 H ATOM 10887 H5 URI 10 2.294 3.285 22.768 1.00 0.00 H ATOM 10888 H2'URI 10 1.160 3.885 27.601 1.00 0.00 H ATOM 10889 H02'URI 10-1.622 3.803 28.288 1.00 0.00 H ATOM 10890 H3'URI 10 0.847 5.668 29.204 1.00 0.00 H ATOM 10891 P GUA 11-1.445 7.275 29.663 1. 00 0.00 P ATOM 10892 01P GUA 11-0.566 7.135 30.847 1.00 0.00 0

ATOM 10893 02P GUA 11-2.909 7.387 29.844 1.00 0.00 0 ATOM 10894 05'GUA 11-0.947 8.549 28.806 1.00 0.00 0 ATOM 10895 C5'GUA 11 0.161 9.344 29.249 1.00 0.00 C ATOM 10896 C4'GUA 11 0.151 10.737 28.621 1.00 0.00 C ATOM 10897 04'GUA 11 0.192 10.675 27.186 1.00 0.00 0 ATOM 10898 Cl'GUA 11-0.839 11.519 26. 642 1.00 0.00 C ATOM 10899 N9 GUA 11-1.988 10.722 26.189 1.00 0.00 N ATOM 10900 C4 GUA 11-3.160 11.202 25.663 1.00 0.00 C ATOM 10901 N3 GUA 11-3.458 12.504 25.456 1.00 0.00 N ATOM 10902 C2 GUA 11-4.673 12.665 24.933 1.00 0.00 C ATOM 10903 N2 GUA 11-5.123 13.889 24.661 1.00 0.00 N ATOM 10904 N1 GUA 11-5.525 11.619 24.639 1.00 0.00 N ATOM 10905 C6 GUA 11-5. 242 10.275 24.842 1.00 0.00 C ATOM 10906 06 GUA 11-6.071 9.417 24.548 1.00 0.00 0 ATOM 10907 C5 GUA 11-3. 949 10. 095 25.398 1.00 0.00 C ATOM 10908 N7 GUA 11-3. 280 8.919 25.753 1.00 0.00 N ATOM 10909 C8 GUA 11-2.160 9.382 26.198 1.00 0.00 C ATOM 10910 C2'GUA 11-1.235 12.443 27.782 1.00 0.00 C ATOM 10911 02'GUA 11-0.323 13.541 27.914 1.00 0.00 0 ATOM 10912 C3'GUA 11-1.135 11.484 28.949 1.00 0.00 C ATOM 10913 03'GUA 11-0.942 12.232 30.151 1.00 0.00 O ATOM 10914 1H5'GUA 11 1.089 8.840 28. 980 1.00 0.00 H ATOM 10915 2H5'GUA 11 0.115 9.444 30.334 1.00 0.00 H ATOM 10916 H4'GUA 11 1.006 11.307 28.981 1.00 0.00 H ATOM 10917 H1'GUA 11-0.446 12.100 25.807 1.00 0.00 H ATOM 10918 1H2 GUA 11-6.043 14.013 24.265 1.00 0.00 H ATOM 10919 2H2 GUA 11-4. 542 14.694 24.850 1. 00 0.00 H ATOM 10920 H1 GUA 11-6.432 11.827 24.249 1.00 0.00 H ATOM 10921 H8 GUA 11-1.380 8.722 26.569 l.'00 0.00 H ATOM 10922 H2'GUA 11-2.263 12.792 27.654 1.00 0.00 H ATOM 10923 H02'GUA 11 0.562 13.172 27.973 1.00 0.00 H ATOM 10924 H3'GUA 11-1.996 10.815 29.002 1.00 0.00 H ATOM 10925 P CYT 12-2.136 12.369 31.222 1.00 0.00 P ATOM 10926 O1P CYT 12-1.644 13.173 32.363 1.00 0.00 0 ATOM 10927 02P CYT 12-2.704 11.023 31.457 1.00 0.00 0 ATOM 10928 05'CYT 12-3.226 13.242 30.419 1.00 0.00 0 ATOM 10929 C5'CYT 12-2.994 14.629 30.156 1.00 0.00 C ATOM 10930 C4'CYT 12-4.121 15.243 29.331 1.00 0.00 C ATOM 10931 04'CYT 12-4.261 14.599 28.060 1.00 0.00 0 ATOM 10932 C1'CYT 12-5. 661 14.465 27.741 1.00 0.00 C ATOM 10933 N1 CYT 12-6.065 13.041 27.678 1.00 0.00 N ATOM 10934 C6 CYT 12-5.242 12. 053 28.143 1.00 0.00 C ATOM 10935 C2 CYT 12-7.300 12.747 27.113 1.00 0.00 C ATOM 10936 02 CYT 12-8.029 13.652 26. 709 1.00 0.00 0 ATOM 10937 N3 CYT 12-7.675 11.443 27.027 1.00 0.00 N ATOM 10938 C4 CYT 12-6.879 10.466 27.476 1.00 0.00 C ATOM 10939 N4 CYT 12-7.274 9.199 27.363 1.00 0.00 N ATOM 10940 C5 CYT 12-5. 609 10.761 28.063 1.00 0.00 C ATOM 10941 C2'CYT 12-6.417 15.209 28.839 1.00 0.00 C ATOM 10942 02'CYT 12-6.623 16.583 28.492 1.00 0.00 0 ATOM 10943 C3'CYT 12-5.467 15. 064 30.008 1.00 0.00 C ATOM 10944 03'CYT 12-5.670 16.155 30.911 1.00 0.00 O ATOM 10945 1H5'CYT 12-2.056 14.736 29.612 1.00 0.00 H ATOM 10946 2H5'CYT 12-2.918 15. 162 31.104 1.00 0.00 H ATOM 10947 H4'CYT 12-3. 927 16.304 29.177 1.00 0.00 H ATOM 10948 Hl'CYT 12-5.859 14.941 26.781 1.00 0.00 H ATOM 10949 H6 CYT 12-4.276 12.312 28.578 1.00 0.00 H ATOM 10950 1H4 CYT 12-6.678 8.453 27.691 1.00 0.00 H ATOM 10951 2H4 CYT 12-8.168 8.985 26.944 1.00 0. 00 H ATOM 10952 H5 CYT 12-4.962 9.967 28.434 1.00 0.00 H

ATOM 10953 H2'CYT 12-7.365 14.710 29.051 1.00 0.00 H ATOM 10954 H02'CYT 12-5.775 16.935 28.213 1.00 0.00 H ATOM 10955 H3'CYT 12-5.564 14.090 30.493 1.00 0.00 H ATOM 10956 P URI 13-6.570 15.964 32.231 1.00 0.00 P ATOM 10957 01P URI 13-6.526 17.222 33.008 1.00 0.00 0 ATOM 10958 02P URI 13-6.188 14.686 32.873 1.00 0.00 O ATOM 10959 05'URI 13-8.049 15.797 31.620 1.00 0.00 0 ATOM 10960 C5'URI 13-8.756 16.932 31.114 1.00 0.00 C ATOM 10961 C4'URI 13-10.068 16.525 30.452 1.00 0.00 C ATOM 10962 04'URI 13-9.854 15.675 29.322 1.00 0.00 0 ATOM 10963 C1'URI 13-10.912 14.697 29.255 1.00 0.00 C ATOM 10964 N1 URI 13-10.386 13.317 29.361 1.00 0.00 N ATOM 10965 C6 URI 13-9.186 13.057 29.971 1.00 0.00 C ATOM 10966 C2 URI 13-11.154 12. 300 28.818 1.00 0.00 C ATOM 10967 02 URI 13-12.233 12.513 28.270 1.00 0.00 O ATOM 10968 N3 URI 13-10.638 11.024 28.929 1.00 0.00 N ATOM 10969 C4 URI 13-9.440 10.675 29.524 1.00 0.00 C ATOM 10970 04 URI 13-9.076 9.502 29.556 1.00 0.00 0 ATOM 10971 C5 URI 13-8.703 11.795 30.066 1.00 0.00 C ATOM 10972 C2'URI 13-11. 858 15.012 30.413 1.00 0.00 C ATOM 10973 02'URI 13-12.923 15.878 30.002 1.00 0.00 O ATOM 10974 C3'URI 13-10.923 15.696 31.389 1.00 0.00 C ATOM 10975 03'URI 13-11.683 16.576 32.223 1.00 0.00 0 ATOM 10976 1H5'URI 13-8.133 17.445 30.382 1.00 0.00 H ATOM 10977 2H5'URI 13-8.971 17.612 31.938 1.00 0.00 H ATOM 10978 H4'URI 13-10.616 17.412 30.139 1.00 0.00 H ATOM 10979 Hl'URI 13-11.447 14.810 28.311 1.00 0.00 H ATOM 10980 H6 URI 13-8.609 13.881 30.393 1.00 0.00 H ATOM 10981 H3 URI 13-11.192 10.274 28.541 1.00 0.00 H ATOM 10982 H5 URI 13-7.745 11.621 30.556 1.00 0.00 H ATOM 10983 H2'URI 13-12.247 14.087 30.844 1.00 0.00 H ATOM 10984 H02'URI 13-13.522 15.356 29.463 1.00 0.00 H ATOM 10985 H3'URI 13-10.332 14.979 31.960 1.00 0.00 H ATOM 10986 P CYT 14-12.313 16.043 33.606 1.00 0.00 P ATOM 10987 01P CYT 14-11.309 15.182 34. 272 1.00 0. 00 0 ATOM 10988 02P CYT 14-12.888 17.199 34.329 1.00 0.00 O ATOM 10989 05'CYT 14-13.522 15.107 33.103 1.00 0.00 O ATOM 10990 C5'CYT 14-14.748 15.685 32.646 1.00 0.00 C ATOM 10991 C4'CYT 14-15.733 14.617 32.180 1.00 0.00 C ATOM 10992 04'CYT 14-15.210 13.856 31.088 1.00 0.00 O ATOM 10993 Cl'CYT 14-15.624 12.481 31.220 1.00 0.00 C ATOM 10994 N1 CYT 14-14.462 11.574 31.334 1.00 0.00 N ATOM 10995 C6 CYT 14-13.285 12. 003 31.875 1.00 0.00 C ATOM 10996 C2 CYT 14-14.614 10.276 30.866 1.00 0.00 C ATOM 10997 02 CYT 14-15.687 9.909 30.391 1.00 0.00 0 ATOM 10998 N3 CYT 14-. 13. 552 9.430 30.956 1.00 0.00 N ATOM 10999 C4 CYT 14-12. 392 9.837 31.483 1.00 0.00 C ATOM 11000 N4 CYT 14-11.371 8.984 31.551 1.00 0.00 N ATOM 11001 C5 CYT 14-12.232 11.173 31.968 1.00 0.00 C ATOM 11002 C2'CYT 14-16.496 12.411 32.471 1.00 0.00 C ATOM 11003 02'CYT 14-17.885 12.545 32.149 1.00 0.00 0 ATOM 11004 C3'CYT 14-15.992 13.595 33.271 1.00 0.00 C ATOM 11005 03'CYT 14-17.054 14.071 34.104 1.00 0.00 0 ATOM 11006 1H5'CYT 14-14. 537 16.360 31.817 1.00 0.00 H ATOM 11007 2H5'CYT 14-15.198 16.252 33.461 1.00 0.00 H ATOM 11008 H4'CYT 14-16.670 15.083 31.881 1.00 0.00 H ATOM 11009 H1'CYT 14-16.219 12.200 30.351 1.00 0.00 H ATOM 11010 H6 CYT 14-13.198 13.027 32.238 1.00 0.00 H ATOM 11011 1H4 CYT 14-10.488 9.281 31. 942 1.00 0.00 H ATOM 11012 2H4 CYT 14-11.481 8.037 31.215 1.00 0.00 H

ATOM 11013 H5 CYT 14-11.292 11.505 32.405 1.00 0.00 H ATOM 11014 H2'CYT 14-16.304 11.479 33.010 1.00 0.00 H ATOM 11015 H02'CYT 14-18.311 12.972 32. 896 1.00 0.00 H ATOM 11016 H3'CYT 14-15.089 13.354 33.834 1.00 0.00 H ATOM 11017 P URI 15-17.162 13.598 35.640 1.00 0.00 P ATOM 11018 01P URI 15-15.880 13.906 36.311 1.00 0.00 0 ATOM 11019 02P URI 15-18.430 14.119 36.196 1.00 0.00 0 ATOM 11020 05'URI 15-17.288 11.997 35.506 1.00 0.00 O ATOM 11021 C5'URI 15-18.502 11.393 35.046 1.00 0.00 C ATOM 11022 C4'URI 15-18.294 9.927 34.672 1.00 0.00 C ATOM 11023 04'URI 15-17.318 9.777 33.630 1.00 0.00 O ATOM 11024 C1'URI 15-16.431 8.688 33.956 1.00 0.00 C ATOM 11025 N1 URI 15-15.084 9.181 34.319 1.00 0.00 N ATOM 11026 C6 URI 15-14.922 10.377 34.964 1.00 0.00 C ATOM 11027 C2 URI 15-13.999 8.382 34.000 1.00 0.00 C ATOM 11028 02 URI 15-14.123 7.308 33.416 1.00 0.00 O ATOM 11029 N3 URI 15-12.759 8.865 34.373 1.00 0.00 N ATOM 11030 C4 URI 15-12.510 10.058 35.027 1.00 0.00 C ATOM 11031 04 URI 15-11.361 10.389 35.309 1.00 0.00 O ATOM 11032 C5 URI 15-13.698 10.828 35.319 1.00 0.00 C ATOM 11033 C2'URI 15-17.083 7.969 35.130 1.00 0.00 C ATOM 11034 02'URI 15-18.044 7.002 34.692 1.00 0.00 O ATOM 11035 C3'URI 15-17.743 9.129 35.843 1.00 0.00 C ATOM 11036 03'URI 15-18.838 8.632 36.618 1.00 0.00 O ATOM 11037 1H5'URI 15-18.862 11.935 34.172 1.00 0.00 H ATOM 11038 2H5'URI 15-19.250 11.455 35.837 1.00 0.00 H ATOM 11039 H4'URI 15-19. 239 9.494 34.346 1.00 0.00 H ATOM 11040 H1'URI 15-16.358 8.010 33.105 1.00 0.00 H ATOM 11041 H6 URI 15-15.798 10.983 35.192 1.00 0.00 H ATOM 11042 H3 URI 15-11. 959 8.291 34.149 1.00 0.00 H ATOM 11043 H5 URI 15-13. 608 11.781 35.838 1.00 0.00 H ATOM 11044 H2'URI 15-16. 321 7.511 35.766 1. 00 0. 00 H ATOM 11045 H02'URI 15-17.573 6.348 34.168 1.00 0.00 H ATOM 11046 H3'URI 15-17. 029 9.706 36.436 1. 00 0.00 H ATOM 11047 P URI 16-18. 605 8.117 38.126 1.00 0.00 P ATOM 11048 01P URI 16-19.930 7.878 38.741 1.00 0.00 0 ATOM 11049 02P URI 16-17.640 9.028 38.783 1.00 0.00 O ATOM 11050 05'URI 16-17.885 6.692 37.908 1.00 0.00 O ATOM 11051 C5'URI 16-17.516 5.885 39.033 1.00 0.00 C ATOM 11052 C4'URI 16-18.213 4.531 39.005 1.00 0.00 C ATOM 11053 04'URI 16-19.623 4.676 38.789 1.00 0.00 O ATOM 11054 C1'URI 16-20.027 3.869 37.679 1.00 0.00 C ATOM 11055 N1 URI 16-21.127 4.510 36.926 1.00 0.00 N ATOM 11056 C6 URI 16-20.990 5.777 36.422 1.00 0.00 C ATOM 11057 C2 URI 16-22.293 3.786 36.750 1.00 0.00 C ATOM 11058 02 URI 16-22.434 2.648 37.194 1.00 0.00 O ATOM 11059 N3 URI 16-23.299 4.417 36.041 1.00 0.00 N ATOM 11060 C4 URI 16-23. 242 5.690 35.500 1.00 0.00 C ATOM 11061 04 URI 16-24.201 6.152 34.886 1.00 0.00 0 ATOM 11062 C5 URI 16-21.990 6.373 35.731 1.00 0.00 C ATOM 11063 C2'URI 16-18. 786 3.722 36.816 1.00 0.00 C ATOM 11064 02'URI 16-18.829 2.527 36.028 1.00 0.00 O ATOM 11065 C3'URI 16-17.684 3.666 37.861 1.00 0. 00 C ATOM 11066 03'URI 16-17.569 2.323 38.339 1.00 0.00 O ATOM 11067 1H5'URI 16-17.783 6.405 39.947 1.00 0.00 H ATOM 11068 2H5'URI 16-16. 441 5.728 39.025 1.00 0.00 H ATOM 11069 H4'URI 16-18.047 4.019 39.953 1.00 0.00 H ATOM 11070 H1'URI 16-20.344 2.889 38.034 1.00 0.00 H ATOM 11071 H6 URI 16-20.056 6.316 36.579 1.00 0.00 H ATOM 11072 H3 URI 16-24.156 3.901 35.905 1.00 0.00 H

ATOM 11073 H5 URI 16-21.848 7.382 35.343 1.00 0. 00 H ATOM 11074 H2'URI 16-18.657 4.606 36.186 1.00 0.00 H ATOM 11075 H02'URI 16-19.536 2.633 35.387 1.00 0. 00 H ATOM 11076 H3'URI 16-16.738 4.041 37.472 1.00 0.00 H ATOM 11077 P CYT 17-16.304 1. 893 39.240 1.00 0.00 P ATOM 11078 01P CYT 17-16.348 2.664 40.503 1.00 0.00 0 ATOM 11079 02P CYT 17-16.243 0.415 39.279 1.00 0.00 0 ATOM 11080 05'CYT 17-15.062 2.429 38.364 1.00 0.00 0 ATOM 11081 C5'CYT 17-14.816 1.892 37.063 1.00 0.00 C ATOM 11082 C4'CYT 17-13.677 2.612 36.352 1.00 0.00 C ATOM 11083 04'CYT 17-13.967 4.007 36.178 1.00 0.00 0 ATOM 11084 C1'CYT 17-12.854 4.772 36.638 1.00 0.00 C ATOM 11085 N1 CYT 17-13.272 6.103 37.120 1.00 0.00 N ATOM 11086 C6 CYT 17-14.539 6.311 37.562 1.00 0.00 C ATOM 11087 C2 CYT 17-12.331 7.126 37.100 1.00 0.00 C ATOM 11088 02 CYT 17-11.191 6.913 36.692 1.00 0.00 0 ATOM 11089 N3 CYT 17-12.712 8.357 37.540 1.00 0.00 N ATOM 11090 C4 CYT 17-13.958 8.575 37.978 1.00 0.00 C ATOM 11091 N4 CYT 17-14.301 9.792 38.397 1.00 0.00 N ATOM 11092 C5 CYT 17-14.923 7.522 37.998 1.00 0.00 C ATOM 11093 C2'CYT 17-12.255 3.937 37.752 1.00 0.00 C ATOM 11094 02'CYT 17-10.888 4.283 38.001 1.00 0.00 0 ATOM 11095 C3'CYT 17-12.388 2.538 37.169 1.00 0.00 C ATOM 11096 03'CYT 17-11.298 2.318 36.265 1.00 0.00 0 ATOM 11097 1H5'CYT 17-15.716 1.983 36.464 1.00 0.00 H ATOM 11098 2H5'CYT 17-14.561 0.840 37.160 1.00 0.00 H ATOM 11099 H4'CYT 17-13.514 2.155 35.378 1.00 0.00 H ATOM 11100 H1'CYT 17-12.133 4.884 35.835 1.00 0.00 H ATOM 11101 H6 CYT 17-15.250 5.488 37.556 1.00 0.00 H ATOM 11102 1H4 CYT 17-15.240 9.967 38.726 1.00 0.00 H ATOM 11103 2H4 CYT 17-13.623 10.541 38.386 1.00 0.00 H ATOM 11104 H5 CYT 17-15.935 7.690 38.357 1.00 0.00 H ATOM 11105 H2'CYT 17-12.861 4.025 38.658 1.00 0.00 H ATOM 11. 106 H02'CYT 17-10.518 3.598 38.562 1.00 0.00 H ATOM 11107 H3'CYT 17-12.445 1.773 37.942 1.00 0.00 H ATOM 11108 P GUA 18-10.602 0.869 36.149 1.00 0.00 P ATOM 11109 01P GUA 18-9.474 0.973 35.196 1.00 0.00 0 ATOM 11110 02P GUA 18-10.365 0.358 37.518 1.00 0.00 0 ATOM 11111 05'GUA 18-11.755-0. 029 35.470 1.00 0.00 0 ATOM 11112 C5'GUA 18-12.091 0.136 34.088 1.00 0.00 C ATOM 11113 C4'GUA 18-13.316-0. 692 33.708 1.00 0.00 C ATOM 11114 04'GUA 18-14.463-0. 312 34.478 1.00 0.00 0 ATOM 11115 C1'GUA 18-15.626-0. 271 33.631 1.00 0.00 C ATOM 11116 N9 GUA 18-16.148 1.106 33.501 1.00 0.00 N ATOM 11117 C4 GUA 18-15.409 2.266 33.416 1.00 0.00 C ATOM 11118 N3 GUA 18-14.059 2.352 33.432 1.00 0.00 N ATOM 11119 C2 GUA 18-13.632 3.614 33.336 1.00 0. 00 C ATOM 11120 N2 GUA 18-12.325 3.877 33.341 1.00 0.00 N ATOM 11121 N1 GUA 18-14.475 4.701 33.233 1.00 0.00 N ATOM 11122 C6 GUA 18-15.861 4.640 33.212 1.00 0.00 C ATOM 11123 06 GUA 18-16.522 5.669 33.109 1.00 0.00 0 ATOM 11124 C5 GUA 18-16.325 3.302 33.315 1.00 0.00 C ATOM 11125 N7 GUA 18-17.632 2.808 33.333 1.00 0.00 N ATOM 11126 C8 GUA 18-17.432 1.538 33.442 1.00 0.00 C ATOM 11127 C2'GUA 18-15.186-0. 823 32.278 1.00 0.00 C ATOM 11128 02'GUA 18-15.378-2. 241 32.203 1.00 0.00 O ATOM 11129 C3'GUA 18-13.715-0. 456 32.260 1.00 0.00 C ATOM 11130 03'GUA 18-13.018-1. 395 31.432 1.00 0.00 0 ATOM 11131 1H5'GUA 18-11.245-0. 179 33.476 1.00 0. 00 H ATOM 11132 2H5'GUA 18-12.298 1.188 33.895 1.00 0.00 H

ATOM 11133 H4'GUA 18-13.110-1. 749 33.865 1.00 0.00 H ATOM 11134 H1'GUA 18-16.401-0. 914 34.052 1.00 0.00 H ATOM 11135 1H2 GUA 18-12.001 4.830 33.268 1.00 0.00 H ATOM 11136 2H2 GUA 18-11.659 3.121 33.417 1.00 0.00 H ATOM 11137 H1 GUA 18-14.073 5.626 33.170 1.00 0.00 H ATOM 11138 H8 GUA 18-18.266 0.837 33.485 1.00 0.00 H ATOM 11139 H2'GUA 18-15.716-0. 311 31.470 1.00 0.00 H ATOM 11140 H02'GUA 18-16.324-2. 403 32.231 1.00 0.00 H ATOM 11141 H3'GUA 18-13.556 0.578 31.953 1.00 0.00 H ATOM 11142 P GUA 19-12.129-0. 895 30.183 1.00 0.00 P ATOM 11143 01P GUA 19-11.606-2. 087 29.479 1.00 0.00 O ATOM 11144 02P GUA 19-11.194 0.145 30.667 1.00 0.00 0 ATOM 11145 05'GUA 19-13.221-0. 186 29.232 1.00 0.00 0 ATOM 11146 C5'GUA 19-14.317-0. 933 28.693 1.00 0.00 C ATOM 11147 C4'GUA 19-15.563-0. 063 28.527 1.00 0.00 C ATOM 11148 04'GUA 19-15.875 0.644 29. 738 1.00 0.00 O ATOM 11149 C1'GUA 19-16.128 2.029 29.434 1.00 0.00 C ATOM 11150 N9 GUA 19-14.995 2.886 29.839 1.00 0.00 N ATOM 11151 C4 GUA 19-15.018 4.252 30.014 1.00 0.00 C ATOM 11152 N3 GUA 19-16.096 5.054 29.864 1.00 0.00 N ATOM 11153 C2 GUA 19-15.808 6.338 30.100 1.00 0.00 C ATOM 11154 N2 GUA 19-16.759 7.265 29.994 1.00 0.00 N ATOM 11155 N1 GUA 19-14.552 6.788 30.455 1.00 0.00 N ATOM 11156 C6 GUA 19-13.431 5.985 30.616 1.00 0.00 C ATOM 11157 06 GUA 19-12.357 6.483 30.941 1.00 0.00 O ATOM 11158 C5 GUA 19-13.728 4.620 30.366 1.00 0.00 C ATOM 11159 N7 GUA 19-12.893 3.500 30.416 1.00 0.00 N ATOM 11160 C8 GUA 19-13.707 2.551 30.099 1.00 0.00 C ATOM 11161 C2'GUA 19-16.332 2.080 27.929 1.00 0.00 C ATOM 11162 02'GUA 19-17. 678 1.747 27.568 1.00 0.00 O ATOM 11163 C3'GUA 19-15. 350 1.019 27.477 1.00 0.00 C ATOM 11164 03'GUA 19-15.770 0.517 26.205 1.00 0.00 0 ATOM 11165 1H5'GUA 19-14.549-1. 760 29.363 1.00 0.00 H ATOM 11166 2H5'GUA 19-14. 031-1.334 27.720 1.00 0.00 H ATOM 11167 H4'GUA 19-16.410-0. 686 28.245 1.00 0.00 H ATOM 11168 H1'GUA 19-17.036 2.357 29.940 1.00 0.00 H ATOM 11169 1H2 GUA 19-17.698 6.997 29.736 1.00 0.00 H ATOM 11170 2H2 GUA 19-16.541 8.235 30.169 1.00 0.00 H ATOM 11171 Hl GUA 19-14.414 7.775 30.614 1.00 0.00 H ATOM 11172 H8 GUA 19-13.371 1.518 30.040 1.00 0.00 H ATOM 11173 H2'GUA 19-16.047 3.060 27.539 1.00 0.00 H ATOM 11174 H02'GUA 19-17.883 0.903 27.977 1.00 0.00 H ATOM 11175 H3'GUA 19-14.323 1.389 27.468 1.00 0.00 H ATOM 11176 P ADE 20-15.254 1.207 24.843 1.00 0. 00 P ATOM 11177 01P ADE 20-15.967 0. 580 23.708 1.00 0.00 0 ATOM 11178 02P ADE 20-13.774 1.226 24.865 1.00 0.00 0 ATOM 11179 05'ADE 20-15.779 2.722 24.996 1. 00 0. 00 O ATOM 11180 C5'ADE 20-17.174 3.023 24.896 1.00 0.00 C ATOM 11181 C4'ADE 20-17.460 4.488 25.216 1.00 0. 00 C ATOM 11182 04'ADE 20-17.036 4.839 26.538 1.00 0.00 O ATOM 11183 C1'ADE 20-16.507 6.181 26.529 1.00 0.00 C ATOM 11184 N9 ADE 20-15.080 6.201 26.910 1.00 0.00 N ATOM 11185 C4 ADE 20-14. 347 7.303 27.289 1.00 0.00 C ATOM 11186 N3 ADE 20-14.793 8.573 27. 365 1.00 0.00 N ATOM 11187 C2 ADE 20-13.833 9.400 27.764 1.00 0.00 C ATOM 11188 N1 ADE 20-12.572 9.086 28. 068 1.00 0.00 N ATOM 11189 C6 ADE 20-12.150 7.812 27.986 1.00 0.00 C ATOM 11190 N6 ADE 20-10.891 7.518 28.309 1.00 0. 00 N ATOM 11191 C5 ADE 20-13.079 6.851 27.572 1.00 0.00 C ATOM 11192 N7 ADE 20-12.989 5.469 27.376 1.00 0.00 N

ATOM 11193 C8 ADE 20-14.189 5.183 26.994 1.00 0.00 C ATOM 11194 C2'ADE 20-16.702 6.704 25.108 1.00 0.00 C ATOM 11195 02'ADE 20-17.954 7.385 24.968 1.00 0.00 0 ATOM 11196 C3'ADE 20-16.675 5.416 24.311 1.00 0.00 C ATOM 11197 03'ADE 20-17.407 5.609 23.097 1.00 0.00 0 ATOM 11198 1H5'ADE 20-17.727 2.393 25.593 1.00 0.00 H ATOM 11199 2H5'ADE 20-17.511 2.810 23.881 1.00 0.00 H ATOM 11200 H4'ADE 20-18.526 4.688 25.114 1.00 0.00 H ATOM 11201 H1'ADE 20-17.077 6.799 27.223 1.00 0.00 H ATOM 11202 H2 ADE 20-14.105 10.452 27.853 1.00 0.00 H ATOM 11203 1H6 ADE 20-10.567 6.563 28.260 1.00 0.00 H ATOM 11204 2H6 ADE 20-10.261 8.250 28.608 1.00 0.00 H ATOM 11205 H8 ADE 20-14.472 4.162 26.741 1.00 0.00 H ATOM 11206 H2'ADE 20-15.867 7.348 24.822 1.00 0.00 H ATOM 11207 H02'ADE 20-18.235 7.281 24.056 1.00 0.00 H ATOM 11208 H3'ADE 20-15.657 5. 062 24.139 1.00 0.00 H ATOM 11209 P GUA 21-16.665 6.161 21.780 1.00 0.00 P ATOM 11210 01P GUA 21-15.404 5.405 21.608 1.00 0.00 0 ATOM 11211 02P GUA 21-17.652 6.209 20.678 1.00 0.00 0 ATOM 11212 05'GUA 21-16.294 7.672 22.196 1.00 0.00 0 ATOM 11213 C5'GUA 21-17.277 8.709 22.123 1.00 0.00 C ATOM 11214 C4'GUA 21-16. 665 10.086 22. 365. 1.00 0.00 C ATOM 11215 04'GUA 21-16.135 10.216 23.688 1.00 0.00 0 ATOM 11216 C1'GUA 21-14. 948 11.036 23.644 1.00 0.00 C ATOM 11217 N9 GUA 21-13.767 10.292 24.126 1.00 0.00 N ATOM 11218 C4 GUA 21-12.616 10.832 24.657 1.00 0.00 C ATOM 11219 N3 GUA 21-12.350 12.151 24.800 1.00 0.00 N ATOM 11220 C2 GUA 21-11.150 12.368 25.348 1.00 0.00 C ATOM 11221 N2 GUA 21-10.723 13.615 25.547 1.00 0.00 N ATOM 11222 N1 GUA 21-10.287 11.359 25.726 1.00 0.00 N ATOM 11223 C6 GUA 21-10.537 10.000 25.591 1.00 0.00 C ATOM 11224 06 GUA 21-9.706 9.180 25.971 1.00 0.00 0 ATOM 11225 C5 GUA 21-11.809 9.760 25.006 1.00 0.00 C ATOM 11226 N7 GUA 21-12.438 8.550 24.697 1.00 0.00 N ATOM 11227 C8 GUA 21-13.555 8.955 24. 195 1.00 0.00 C ATOM 11228 C2'GUA 21-14.776 11.459 22.186 1.00 0.00 C ATOM 11229 02'GUA 21-15.402 12.722 21. 929 1.00 0.00 0 ATOM 11230 C3'GUA 21-15.476 10.329 21.459 1.00 0.00 C ATOM 11231 03'GUA 21-15.949 10.806 20.196 1.00 0.00 0 ATOM 11232 lH5'GUA 21-18.047 8.526 22.872 1.00 0.00 H ATOM 11233 2H5'GUA 21-17.733 8.694 21.133 1.00 0.00 H ATOM 11234 H4'GUA 21-17.416 10.857 22.201 1.00 0.00 H ATOM 11235 Hl'GUA 21-15.096 11.921 24.264 1.00 0.00 H ATOM 11236 1H2 GUA 21-11.306 14.397 25.284 1.00 0.00 H ATOM 11237 2H2 GUA 21-9.815 13.778 25.959 1.00 0.00 H ATOM 11238 H1 GUA 21-9.399 11.606 26.138 1.00 0.00 H ATOM 11239 H8 GUA 21-14.296 8.248 23.826 1.00 0.00 H ATOM 11240 H2'GUA 21-13.716 11.484 21.923 1.00 0.00 H ATOM 11241 H02'GUA 21-14.836 13.403 22.302 1.00 0.00 H ATOM 11242 H3'GUA 21-14.841 9. 446 21.368 1.00 0.00 H ATOM 11243 P ADE 22-14.994 10.767 18.900 1.00 0.00 P ATOM 11244 O1P ADE 22-15.827 11.018 17.702 1.00 0.00 O ATOM 11245 02P ADE 22-14.157 9.548 18.974 1.00 0.00 0 ATOM 11246 05'ADE 22-14.042 12.045 19.130 1.00 0.00 0 ATOM 11247 C5'ADE 22-14.584 13.368 19.075 1.00 0.00 C ATOM 11248 C4'ADE 22-13.587 14.408 19.577 1.00 0.00 C ATOM 11249 04'ADE 22-13.164 14.138 20.919 1.00 0.00 0 ATOM 11250 C1'ADE 22-11.761 14.447 21.046 1.00 0.00 C ATOM 11251 N9 ADE 22-10.960 13.238 21.319 1.00 0.00 N ATOM 11252 C4 ADE 22-9.685 13.205 21.834 1.00 0.00 C

ATOM 11253 N3 ADE 22-8.950 14.269 22.214 1.00 0.00 N ATOM 11254 C2 ADE 22-7.759 13.896 22.666 1.00 0.00 C ATOM 11255 N1 ADE 22-7.287 12.652 22.760 1.00 0.00 N ATOM 11256 C6 ADE 22-8.040 11.606 22.374 1.00 0.00 C ATOM 11257 N6 ADE 22-7.547 10.372 22.467 1.00 0.00 N ATOM 11258 C5 ADE 22-9.317 11.881 21.880 1.00 0.00 C ATOM 11259 N7 ADE 22-10.343 11. 062 21.402 1.00 0.00 N ATOM 11260 C8 ADE 22-11.249 11.930 21.102 1.00 0.00 C ATOM 11261 C2'ADE 22-11.349 15.074 19.718 1.00 0.00 C ATOM 11262 02'ADE 22-11.533 16.495 19.725 1.00 0.00 0 ATOM 11263 C3'ADE 22-12.305 14.388 18.766 1.00 0.00 C ATOM 11264 03'ADE 22-12.471 15.207 17.606 1.00 0.00 0 ATOM 11265 1H5'ADE 22-15.481 13.411 19.692 1.00 0.00 H ATOM 11266 2H5'ADE 22-14. 850 13.600 18.044 1.00 0.00 H ATOM 11267 H4'ADE 22-14.035 15.399 19.533 1.00 0.00 H ATOM 11268 H1'ADE 22-11.619 15.170 21.850 1.00 0.00 H ATOM 11269 H2 ADE 22-7.094 14.695 22.996 1.00 0.00 H ATOM 11270 1H6 ADE 22-8.105 9.583 22.173 1.00 0.00 H ATOM 11271 2H6 ADE 22-6.617 10.225 22.832 1.00 0.00 H ATOM 11272 H8 ADE 22-12.208 11.623 20.686 1.00 0.00 H ATOM 11273 H2'ADE 22-10.315 14.810 19.477 1.00 0.00 H ATOM 11274 H02'ADE 22-12.449 16.663 19.960 1.00 0.00 H ATOM 11275 H3'ADE 22-11.984 13.373 18.526 1.00 0.00 H ATOM 11276 P CYT 23-11.407 15.129 16.399 1.00 0.00 P ATOM 11277 01P CYT 23-11.874 16.016 15.311 1.00 0.00 0 ATOM 11278 02P CYT 23-11.128 13.702 16.119 1.00 0.00 0 ATOM 11279 05'CYT 23-10.086 15.780 17.053 1.00 0.00 0 ATOM 11280 C5'CYT 23-10.013 17.190 17.284 1.00 0.00 C ATOM 11281 C4'CYT 23-8.658 17.602 17.853 1.00 0.00 C ATOM 11282 04'CYT 23-8.388 16.974 19.107 1.00 0.00 O ATOM 11283 C1'CYT 23-6.966 16.767 19.233 1.00 0.00 C ATOM 11284 N1 CYT 23-6.645 15.346 19.492 1.00 0.00 N ATOM 11285 C6 CYT 23-7.368 14.342 18.913 1.00 0.00 C ATOM 11286 C2 CYT 23-5.573 15.074 20.332 1.00 0.00 C ATOM 11287 02 CYT 23-4.938 15.995 20. 843 1.00 0.00 0 ATOM 11288 N3 CYT 23-5.253 13.774 20.569 1.00 0.00 N ATOM 11289 C4 CYT 23-5.951 12.780 20.008 1.00 0.00 C ATOM 11290 N4 CYT 23-5.606 11.518 20. 260 1.00 0.00 N ATOM 11291 C5 CYT 23-7.056 13.053 19.143 1.00 0.00 C ATOM 11292 C2'CYT 23-6.341 17.238 17.915 1.00 0.00 C ATOM 11293 02'CYT 23-5.844 18.578 18.020 1.00 0.00 0 ATOM 11294 C3'CYT 23-7.519 17.151 16.963 1.00 0.00 C ATOM 11295 03'CYT 23-7.347 18.110 15.915 1.00 0.00 0 ATOM 11296 1H5'CYT 23-10.795 17.477 17.987 1.00 0.00 H ATOM 11297 2H5'CYT 23-10.174 17.712 16.341 1.00 0.00 H ATOM 11298 H4'CYT 23-8.622 18.683 17.976 1.00 0.00 H ATOM 11299 H1'CYT 23-6. 584 17.379 20.051 1.00 0.00 H ATOM 11300 H6 CYT 23-8.206 14.587 18.259 1.00 0.00 H ATOM 11301 1H4 CYT 23-6.124 10.759 19.842 1.00 0.00 H ATOM 11302 2H4 CYT 23-4.825 11.321 20.870 1.00 0.00 H ATOM 11303 H5 CYT 23-7.624 12.245 18.684 1.00 0.00 H ATOM 11304 H2'CYT 23-5.551 16.549 17.605 1.00 0.00 H ATOM 11305 H02'CYT 23-5.033 18.542 18.533 1.00 0.00 H ATOM 11306 H3'CYT 23-7.667 16.137 16.587 1.00 0.00 H ATOM 11307 P GUA 24-6.342 17. 818 14.691 1.00 0.00 P ATOM 11308 01P GUA 24-6.786 18.616 13.526 1.00 0.00 0 ATOM 11309 02P GUA 24-6.179 16.352 14.560 1.00 0.00 0 ATOM 11310 05'GUA 24-4.953 18.433 15.223 1.00 0.00 O ATOM 11311 C5'GUA 24-4.824 19. 839 15.458 1. 00 0.00 C ATOM 11312 C4'GUA 24-3.405 20.212 15.875 1.00 0.00 C

ATOM 11313 04'GUA 24-3.006 19.513 17.065 1.00 0.00 0 ATOM 11314 Cl'GUA 24-1.687 18.968 16.877 1.00 0.00 C ATOM 11315 N9 GUA 24-1.729 17.507 16.686 1.00 0.00 N ATOM 11316 C4 GUA 24-0.648 16.663 16.670 1.00 0.00 C ATOM 11317 N3 GUA 24 0.640 17.033 16.836 1.00 0.00 N ATOM 11318 C2 GUA 24 1.474 15.996 16.772 1.00 0.00 C ATOM 11319 N2 GUA 24 2.784 16.188 16.923 1.00 0.00 N ATOM 11320 N1 GUA 24 1.062 14.695 16.559 1.00 0.00 N ATOM 11321 C6 GUA 24-0.254 14.290 16.385 1.00 0.00 C ATOM 11322 06 GUA 24-0.516 13.103 16.198 1.00 0.00 0 ATOM 11323 C5 GUA 24-1.149 15.390 16.453 1.00 0.00 C ATOM 11324 N7 GUA 24-2.542 15.424 16.332 1.00 0.00 N ATOM 11325 C8 GUA 24-2.786 16.683 16.480 1.00 0.00 C ATOM 11326 C2'GUA 24-1.133 19. 660 15.642 1.00 0.00 C ATOM 11327 02'GUA 24-0.558 20.932 15.964 1.00 0.00 0 ATOM 11328 C3'GUA 24-2.391 19.804 14.815 1.00 0.00 C ATOM 11329 03'GUA 24-2.220 20.887 13.894 1.00 0.00 0 ATOM 11330 1H5'GUA 24-5.515 20.132 16.249 1.00 0.00 H ATOM 11331 2H5'GUA 24-5.080 20.377 14.545 1.00 0.00 H ATOM 11332 H4'GUA 24-3.343 21.285 16.048 1.00 0.00 H ATOM 11333 H1'GUA 24-1.063 19.203 17.739 1.00 0.00 H ATOM 11334 1H2 GUA 24 3.141 17.118 17.085 1.00 0.00 H ATOM 11335 2H2 GUA 24 3.418 15.405 16.876 1.00 0.00 H ATOM 11336 H1 GUA 24 1.756 13.966 16.523 1.00 0.00 H ATOM 11337 H8 GUA 24-3.804 17.070 16.438 1.00 0.00 H ATOM 11338 H2'GUA 24-0.412 19.014 15.137 1.00 0.00 H ATOM 11339 H02'GUA 24 0. 299 20.765 16.364 1.00 0.00 H ATOM 11340 H3'GUA 24-2. 665 18.870 14.321 1.00 0.00 H ATOM 11341 P ADE 25-1.550 20.637 12.449 1.00 0.00 P ATOM 11342 01P ADE 25-2.081 19.367 11.904 1.00 0.00 0 ATOM 11343 02P ADE 25-1.670 21.884 11.661 1.00 0.00 O ATOM 11344 05'ADE 25 0.004 20.417 12.812 1.00 0.00 0 ATOM 11345 C5'ADE 25 0.769 21.479 13.390 1.00 0.00 C ATOM 11346 C4'ADE 25 2.114 20. 988 13.917 1.00 0.00 C ATOM 11347 04'ADE 25 1.958 19.896 14.835 1.00 0.00 O ATOM 11348 C1'ADE 25 2.952 18. 891 14.559 1.00 0.00 C ATOM 11349 N9 ADE 25 2.337 17.672 13.995 1.00 0.00 N ATOM 11350 C4 ADE 25 2.942 16.447 13.823 1.00 0.00 C ATOM 11351 N3 ADE 25 4.218 16.135 14.125 1.00 0.00 N ATOM 11352 C2 ADE 25 4.486 14.865 13.837 1.00 0.00 C ATOM 11353 N1 ADE 25 3.653 13.962 13.317 1.00 0.00 N ATOM 11354 C6 ADE 25 2.384 14.298 13.025 1.00 0.00 C ATOM 11355 N6 ADE 25 1.562 13.381 12. 517 1.00 0.00 N ATOM 11356 C5 ADE 25 1.989 15.613 13.286 1.00 0.00 C ATOM 11357 N7 ADE 25 0.779 16.290 13.109 1.00 0.00 N ATOM 11358 C8 ADE 25 1.074 17.468 13.544 1.00 0.00 C ATOM 11359 C2'ADE 25 3.921 19.529 13.569 1.00 0.00 C ATOM 11360 02'ADE 25 4.948 20.267 14.243 1.00 0.00 O ATOM 11361 C3'ADE 25 2.989 20.441 12.800 1.00 0.00 C ATOM 11362 03'ADE 25 3.744 21.524 12.245 1.00 0.00 O ATOM 11363 1H5'ADE 25 0.204 21.914 14.214 1.00 0.00 H ATOM 11364 2H5'ADE 25 0.941 22.245 12.634 1.00 0.00 H ATOM 11365 H4'ADE 25 2.631 21.805 14.418 1.00 0.00 H ATOM 11366 H1'ADE 25 3.482 18.642 15.478 1.00 0.00 H ATOM 11367 H2 ADE 25 5.499 14.523 14.050 1.00 0.00 H ATOM 11368 1H6 ADE 25 0.605 13.624 12.303 1.00 0.00 H ATOM 11369 2H6 ADE 25 1.896 12.444 12.344 1.00 0.00 H ATOM 11370 H8 ADE 25 0.338 18. 271 13.542 1.00 0.00 H ATOM 11371 H2'ADE 25 4.347 18.769 12.909 1.00 0.00 H ATOM 11372 H02'ADE 25 5.613 19.635 14.527 1.00 0.00 H

ATOM 11373 H3'ADE 25 2.415 19.896 12.048 1.00 0.00 H ATOM 11374 P CYT 26 4.488 21.366 10. 825 1.00 0.00 P ATOM 11375 01P CYT 26 3.616 20.576 9.927 1.00 0.00 O ATOM 11376 02P CYT 26 4.967 22.701 10.403 1.00 0.00 0 ATOM 11377 05'CYT 26 5.767 20.466 11.203 1.00 0.00 O ATOM 11378 C5'CYT 26 6.715 20.924 12.171 1.00 0.00 C ATOM 11379 C4'CYT 26 7.641 19.801 12.625 1.00 0.00 C ATOM 11380 04'CYT 26 6.908 18.700 13.185 1.00 0.00 0 ATOM 11381 C1'CYT 26 7.449 17.461 12.683 1.00 0.00 C ATOM 11382 N1 CYT 26 6.525 16.810 11.730 1.00 0.00 N ATOM 11383 C6 CYT 26 5.667 17.550 10.971 1.00 0.00 C ATOM 11384 C2 CYT 26 6.597 15.429 11.604 1.00 0.00 C ATOM 11385 02 CYT 26 7.376 14.781 12. 302 1.00 0.00 O ATOM 11386 N3 CYT 26 5.788 14.822 10.694 1.00 0.00 N ATOM 11387 C4 CYT 26 4.945 15.538 9.939 1.00 0.00 C ATOM 11388 N4 CYT 26 4.167 14. 912'9. 057 1.00 0.00 N ATOM 11389 C5 CYT 26 4.869 16.961 10.069 1.00 0.00 C ATOM 11390 C2'CYT 26 8.750 17.836 11.987 1.00 0.00 C ATOM 11391 02'CYT 26 9.848 17.887 12.907 1.00 0.00 O ATOM 11392 C3'CYT 26 8.400 19.207 11.452 1.00 0.00 C ATOM 11393 03'CYT 26 9.605 19.955 11.260 1.00 0.00 0 ATOM 11394 1H5'CYT 26 6.179 21.315 13.037 1.00 0.00 H ATOM 11395 2H5'CYT 26 7.313 21.723 11.733 1.00 0.00 H ATOM 11396 H4'CYT 26 8.344 20.179 13.364 1.00 0.00 H ATOM 11397 H1'CYT 26 7.657 16.787 13.515 1.00 0.00 H ATOM 11398 H6 CYT 26 5.616 18.632 11.109 1.00 0.00 H ATOM 11399 1H4 CYT 26 3.526 15.442 8.482 1.00 0.00 H ATOM 11400 2H4 CYT 26 4.216 13.907 8.963 1.00 0.00 H ATOM 11401 H5 CYT 26 4.206 17.550 9.443 1.00 0.00 H ATOM 11402 H2'CYT 26 8.952 17.143 11.166 1.00 0.00 H ATOM 11403 H02'CYT 26 9.605 18.496 13.609 1.00 0.00 H ATOM 11404 H3'CYT 26 7.785 19.149 10.549 1.00 0.00 H ATOM 11405 P CYT 27 10.212 20.168 9.784 1.00 0.00 P ATOM 11406 01P CYT 27 9.129 20.661 8.903 1.00 0.00 O ATOM 11407 02P CYT 27 11.471 20.937 9.907 1. 00 0.00 0 ATOM 11408 05'CYT 27 10.579 18. 666 9.336 1.00 0.00 0 ATOM 11409 C5'CYT 27 11.530 17.898 10.080 1.00 0.00 C ATOM 11410 C4'CYT 27 11.454 16.414 9.731 1.00 0.00 C ATOM 11411 04'CYT 27 10.136 15. 889 9.920 1.00 0.00 0 ATOM 11412 Cl'CYT 27 9.874 14.892 8.910 1.00 0.00 C ATOM 11413 N1 CYT 27 8.714 15.254 8.064 1.00 0.00 N ATOM 11414 C6 CYT 27 8.132 16.487 8.145 1.00 0.00 C ATOM 11415 C2 CYT 27 8.246 14.290 7.180 1.00 0.00 C ATOM 11416 02 CYT 27 8.792 13.190 7.117 1.00 0.00 0 ATOM 11417 N3 CYT 27 7.186 14.600 6.388 1.00 0.00 N ATOM 11418 C4 CYT 27 6.604 15.802 6.456 1.00 0.00 C ATOM 11419 N4 CYT 27 5.566 16.067 5.663 1.00 0.00 N ATOM 11420 C5 CYT 27 7.079 16.802 7.363 1.00 0.00 C ATOM 11421 C2'CYT 27 11.145 14.795 8.068 1.00 0.00 C ATOM 11422 02'CYT 27 12. 014 13.764 8. 548 1.00 0.00 0 ATOM 11423 C3'CYT 27 11.745 16.172 8.263 1.00 0.00 C ATOM 11424 03'CYT 27 13.163 16.093 8. 078 1.00 0. 00 0 ATOM 11425 1H5'CYT 27 11.333 18.022 11.145 1.00 0.00 H ATOM 11426 2H5'CYT 27 12.533 18.264 9. 860 1.00 0.00 H ATOM 11427 H4'CYT 27 12.157 15.853 10.343 1.00 0.00 H ATOM 11428 H1'CYT 27 9.687 13.931 9.391 1.00 0.00 H ATOM 11429 H6 CYT 27 8.525 17.225 8.844 1.00 0.00 H ATOM 11430 1H4 CYT 27 5.116 16.970 5.704 1.00 0.00 H ATOM 11431 2H4 CYT 27 5.232 15.363 5.019 1. 00 0.00 H ATOM 11432 H5 CYT 27 6.607 17.783 7.416 1. 00 0. 00 H

ATOM 11433 H2'CYT 27 10.890 14.637 7.017 1.00 0.00 H ATOM 11434 H02'CYT 27 12.761 13.719 7.947 1.00 0.00 H ATOM 11435 H3'CYT 27 11.274 16.919 7.622 1.00 0.00 H ATOM 11436 P GUA 28 13.795 16.012 6.597 1.00 0.00 P ATOM 11437 01P GUA 28 12.929 16.788 5.679 1.00 0.00 0 ATOM 11438 02P GUA 28 15.238 16.328 6.691 1.00 0.00 0 ATOM 11439 05'GUA 28 13.640 14.450 6.233 1.00 0.00 0 ATOM 11440 C5'GUA 28 14.577 13.486 6.727 1.00 0.00 C ATOM 11441 C4'GUA 28 14.458 12.156 5. 986 1.00 0.00 C ATOM 11442 04'GUA 28 13.145 11.590 6.117 1.00 0.00 0 ATOM 11443 Cl'GUA 28 12.667 11. 180, 4.822 1.00 0.00 C ATOM 11444 N9 GUA 28 11.636 12.111 4.318 1.00 0.00 N ATOM 11445 C4 GUA 28 10.692 11.853 3.347 1.00 0.00 C ATOM 11446 N3 GUA 28 10.553 10.696 2.659 1.00 0.00 N ATOM 11447 C2 GUA 28 9.544 10.748 1.782 1.00 0.00 C ATOM 11448 N2 GUA 28 9.273 9.693 1.015 1.00 0.00 N ATOM 11449 N1 GUA 28 8.741 11.857 1.604 1.00 0.00 N ATOM 11450 C6 GUA 28 8.865 13.053 2. 295 1.00 0.00 C ATOM 11451 06 GUA 28 8.095 13.982 2.064 1.00 0.00 0 ATOM 11452 C5 GUA 28 9.934 13.008 3.228 1.00 0.00 C ATOM 11453 N7 GUA 28 10.390 13.990 4.112 1.00 0.00 N ATOM 11454 C8 GUA 28 11.369 13.385 4.694 1.00 0.00 C ATOM 11455 C2'GUA 28 13.893 11.172 3.922 1.00 0.00 C ATOM 11456 02'GUA 28 14.624 9.946 4.039 1.00 0.00 0 ATOM 11457 C3'GUA 28 14.666 12.343 4.490 1.00 0.00 C ATOM 11458 03'GUA 28 16.055 12.168 4.197 1.00 0.00 0 ATOM 11459 lH5'GUA 28 14.393 13.320 7.788 1.00 0.00 H ATOM 11460 2H5'GUA 28 15.587 13.875 6.598 1.00 0.00 H ATOM 11461 H4'GUA 28 15.195 11.453 6.373 1.00 0.00 H ATOM 11462 H1'GUA 28 12. 253 10.173 4.887 1.00 0.00 H ATOM 11463 1H2 GUA 28 9.829 8.854 1.096 1.00 0.00 H ATOM 11464 2H2 GUA 28 8.511 9.732 0.353 1.00 0.00 H ATOM 11465 H1 GUA 28 7. 996 11.814 0.924 1.00 0.00 H ATOM 11466 H8 GUA 28 11.964 13.883 5.459 1.00 0.00 H ATOM 11467 H2'GUA 28 13.606 11.366 2.886 1.00 0.00 H ATOM 11468 H02'GUA 28 15.528 10.126 3.771 1.00 0.00 H ATOM 11469 H3'GUA 28 14.277 13.300 4.137 1.00 0. 00 H ATOM 11470 P CYT 29 16.731 12.949 2.961 1.00 0.00 P ATOM 11471 01P CYT 29 18.185 12.673 2.977 1.00 0.00 0 ATOM 11472 02P CYT 29 16.244 14.347 2.973 1.00 0.00 0 ATOM 11473 05'CYT 29 16.088 12.204 1.688 1.00 0.00 0 ATOM 11474 C5'CYT 29 16.470 10.865 1.357 1.00 0.00 C ATOM 11475 C4'CYT 29 15.544 10.262 0.306 1.00 0.00 C ATOM 11476 04'CYT 29 14.187 10.207 0.767 1.00 0.00 0 ATOM 11477 C1'CYT 29 13.300 10.616-0. 293 1.00 0.00 C ATOM 11478 N1 CYT 29 12.646 11.908 0.020 1.00 0.00 N ATOM 11479 C6 CYT 29 13.253 12. 826 0.830 1.00 0.00 C ATOM 11480 C2 CYT 29 11.393 12.147-0. 531 1.00 0.00 C ATOM 11481 02 CYT 29 10.866 11.309-1. 261 1.00 0.00 0 ATOM 11482 N3 CYT 29 10.776 13.326-0. 243 1.00 0.00 N ATOM 11483 C4 CYT 29 11.359 14.233 0.550 1.00 0.00 C ATOM 11484 N4 CYT 29 10.724 15.374 0.815 1.00 0.00 N ATOM 11485 C5 CYT 29 12.649 13.993 1.119 1.00 0.00 C ATOM 11486 C2'CYT 29 14.166 10.724-1. 544 1.00 0.00 C ATOM 11487 02'CYT 29 14.249 9.472-2. 237 1.00 0.00 0 ATOM 11488 C3'CYT 29 15.500 11.121-0. 945 1.00 0.00 C ATOM 11489 03'CYT 29 16.548 10.702-1. 825 1.00 0.00 0 ATOM 11490 1H5'CYT 29 16.436 10.251 2.257 1.00 0.00 H ATOM 11491 2H5'CYT 29 17.490 10.873 0.970 1.00 0.00 H ATOM 11492 H4'CYT 29 15.880 9.258 0.051 1.00 0.00 H

ATOM 11493 H1'CYT 29 12.539 9.849-0. 444 1.00 0.00 H ATOM 11494 H6 CYT 29 14.238 12.612 1.246 1.00 0.00 H ATOM 11495 1H4 CYT 29 11.153 16.064 1.415 1.00 0.00 H ATOM 11496 2H4 CYT 29 9.813 15.550 0.414 1.00 0.00 H ATOM 11497 H5 CYT 29 13.126 14.730 1. 766 1.00 0.00 H ATOM 11498 H2'CYT 29 13.790 11.513-2. 198 1.00 0.00 H ATOM 11499 H02'CYT 29 13. 422 9.353-2. 710 1.00 0.00 H ATOM 11500 H3'CYT 29 15.543 12.187-0. 715 1.00 0.00 H ATOM 11501 P CYT 30 17.166 11.724-2. 905 1.00 0.00 P ATOM 11502 01P CYT 30 17.341 13.041-2. 253 1.00 0.00 0 ATOM 11503 02P CYT 30 18.319 11.066-3. 559 1.00 0.00 0 ATOM 11504 05'CYT 30 15.978 11.852-3. 985 1.00 0.00 0 ATOM 11505 C5'CYT 30 15.652 10.754-4. 843 1.00 0.00 C ATOM 11506 C4'CYT 30 14.280 10.933-5. 486 1.00 0.00 C ATOM 11507 04'CYT 30 13.252 11.078-4. 501 1.00 0.00 0 ATOM 11508 C1'CYT 30 12.299 12.058-4. 950 1.00 0.00 C ATOM 11509 N1 CYT 30 12.283 13.243-4. 064 1.00 0.00 N ATOM 11510 C6 CYT 30 13.404 13.639-3. 390 1.00 0.00 C ATOM 11511 C2 CYT 30 11.086 13.934-3. 943 1.00 0.00 C ATOM 11512 02 CYT 30 10.092 13.566-4. 567 1.00 0.00 0 ATOM 11513 N3 CYT 30 11.049 15.024-3. 130 1.00 0.00 N ATOM 11514 C4 CYT 30 12.138 15.424-2. 463 1.00 0.00 C ATOM 11515 N4 CYT 30 12.065 16.498-1. 677 1.00 0.00 N ATOM 11516 C5 CYT 30 13.375 14.716-2. 583 1.00 0.00 C ATOM 11517 C2'CYT 30 12.721 12.433-6. 368 1.00 0.00 C ATOM 11518 02'CYT 30 12.097 11.585-7. 340 1.00 0.00 0 ATOM 11519 C3'CYT 30 14. 217 12.207-6. 310 1.00 0.00 C ATOM 11520 03'CYT 30 14.783 12.031-7. 613 1.00 0.00 0 ATOM 11521 1H5'CYT 30 15.655 9.832-4. 260 1.00 0.00 H ATOM 11522 2H5'CYT 30 16.406 10.680-5. 628 1.00 0.00 H ATOM 11523 H4'CYT 30 14.056 10.075-6. 118 1.00 0.00 H ATOM 11524 H1'CYT 30 11.305 11.609-4. 975 1.00 0.00 H ATOM 11525 H6 CYT 30 14.331 13.078-3. 508 1.00 0.00 H ATOM 11526 1H4 CYT 30 12.880 16.808-1. 169 1.00 0.00 H ATOM 11527 2H4 CYT 30 11.196 17.006-1. 598 1.00 0.00 H ATOM 11528 H5 CYT 30 14.264 15.038-2. 041 1.00 0.00 H ATOM 11529 H2'CYT 30 12.501 13.486-6. 564 1.00 0.00 H ATOM 11530 H02'CYT 30 12. 209 10.679-7. 042 1.00 0.00 H ATOM 11531 H3'CYT 30 14.700 13.029-5. 774 1.00 0.00 H ATOM 11532 H03'CYT 30 14.241 11.387-8. 075 1.00 0.00 H TER ATOM 11533 05'GUA 1-5.001 24.475 21.614 1.00 0.00 0 ATOM 11534 C5'GUA 1-5. 962 25.421 21.137 1.00 0.00 C ATOM 11535 C4'GUA 1-5.337 26.796 20.916 1.00 0.00 C ATOM 11536 04'GUA 1-4.714 27.290 22.114 1.00 0.00 0 ATOM 11537 C1'GUA 1-3.395 27.777 21.804 1.00 0.00 C ATOM 11538 N9 GUA 1-2.354 26.838 22.278 1.00 0.00 N ATOM 11539 C4 GUA 1-1.148 27.167 22.858 1.00 0.00 C ATOM 11540 N3 GUA 1-0.686 28.419 23.075 1.00 0.00 N ATOM 11541 C2 GUA 1 0.518 28.419 23.656 1.00 0.00 C ATOM 11542 N2 GUA 1 1.125 29.573 23.933 1.00 0.00 N ATOM 11543 N1 GUA 1 1.206 27.271 23.996 1.00 0.00 N ATOM 11544 C6 GUA 1 0.754 25.976 23.784 1.00 0.00 C ATOM 11545 06 GUA 1 1.442 25.018 24.129 1.00 0.00 0 ATOM 11546 C5 GUA 1-0. 525 25.965 23.164 1.00 0.00 C ATOM 11547 N7 GUA 1-1.323 24.885 22.781 1.00 0.00 N ATOM 11548 C8 GUA 1-2.352 25.481 22.281 1.00 0.00 C ATOM 11549 C2'GUA 1-3.362 27.916 20.291 1.00 0.00 C ATOM 11550 02'GUA 1-3.928 29.162 19.864 1.00 0.00 O ATOM 11551 C3'GUA 1-4.221 26. 739 19.881 1.00 0.00 C

ATOM 11552 03'GUA 1-4. 776 27.000 18.588 1.00 0.00 O ATOM 11553 H5'GUA 1-4.796 24.710 22.522 1.00 0.00 H ATOM 11554 1H5'GUA 1-6.765 25.509 21. 868 1.00 0.00 H ATOM 11555 2H5'GUA 1-6.376 25.062 20.194 1.00 0.00 H ATOM 11556 H4'GUA 1-6.102 27.500 20.591 1.00 0.00 H ATOM 11557 H1'GUA 1-3.246 28. 753 22.266 1.00 0.00 H ATOM 11558 1H2 GUA 1 0.675 30.448 23.703 1.00 0.00 H ATOM 11559 2H2 GUA 1 2.033 29.574 24.375 1. 00 0.00 H ATOM 11560 H1 GUA 1 2.109 27.356 24.438 1.00 0.00 H ATOM 11561 H8 GUA 1-3.185 24.915 21.867 1.00 0.00 H ATOM 11562 H2'GUA 1-2. 343 27.796 19.921 1.00 0.00 H ATOM 11563 H02'GUA 1-4.810 29.218 20.239 1.00 0.00 H ATOM 11564 H3'GUA 1-3.670 25.798 19.921 1.00 0.00 H ATOM 11565 P GUA 2-3.972 26.583 17.255 1.00 0.00 P ATOM 11566 01P GUA 2-4. 833 26.867 16.086 1.00 0.00 O ATOM 11567 02P GUA 2-3.421 25.223 17.452 1.00 0.00 0 ATOM 11568 05'GUA 2-2.744 27.625 17.246 1.00 0.00 0 ATOM 11569 C5'GUA 2-2.945 28.987 16.854 1.00 0.00 C ATOM 11570 C4'GUA 2-1.679 29.818 17.041 1.00 0.00 C ATOM 11571 04'GUA 2-1.268 29.848 18.415 1.00 0.00 0 ATOM 11572 C1'GUA 2 0. 150 29.618 18.502 1.00 0.00 C ATOM 11573 N9 GUA 2 0.440 28.289 19.079 1.00 0.00 N ATOM 11574 C4 GUA 2 1.516 27.955 19.870 1.00 0.00 C ATOM 11575 N3 GUA 2 2.517 28.785 20.240 1.00 0.00 N ATOM 11576 C2 GUA 2 3.422 28.173 21.011 1.00 0.00 C ATOM 11577 N2 GUA 2 4.480 28.849 21.461 1.00 0.00 N ATOM 11578 N1 GUA 2 3.338 26.847 21.384 1.00 0.00 N ATOM 11579 C6 GUA 2 2.321 25.976 21.017 1.00 0.00 C ATOM 11580 06 GUA 2 2.332 24. 812 21.408 1.00 0.00 0 ATOM 11581 C5 GUA 2 1.356 26.617 20. 197 1.00 0.00 C ATOM 11582 N7 GUA 2 0.192 26.104 19. 620 1.00 0.00 N ATOM 11583 C8 GUA 2-0.268 27.134 18.996 1.00 0.00 C ATOM 11584 C2'GUA 2 0.676 29. 731 17.077 1.00 0.00 C ATOM 11585 02'GUA 2 0.989 31.088 16.737 1.00 0.00 0 ATOM 11586 C3'GUA 2-0.506 29.213 16. 285 1.00 0.00 C ATOM 11587 03'GUA 2-0.467 29.781 14.971 1.00 0. 00 O ATOM 11588 1H5'GUA 2-3.746 29.417 17.456 1.00 0.00 H ATOM 11589 2H5'GUA 2-3.236 29.015 15.804 1. 00 0.00 H ATOM 11590 H4'GUA 2-1.853 30.836 16.695 1.00 0.00 H ATOM 11591 H1'GUA 2 0.606 30.392 19.121 1.00 0.00 H ATOM 11592 1H2 GUA 2 4.596 29.822 21.219 1.00 0.00 H ATOM 11593 2H2 GUA 2 5.165 28.387 22. 043 1.00 0.00 H ATOM 11594 H1 GUA 2 4.063 26. 458 21.970 1.00 0.00 H ATOM 11595 H8 GUA 2-1.193 27.078 18.422 1.00 0.00 H ATOM 11596 H2'GUA 2 1.543 29.081 16.941 1.00 0.00 H ATOM 11597 H02'GUA 2 1.778 31.330 17.228 1.00 0.00 H ATOM 11598 H3'GUA 2-0.543 28.123 16.272 1.00 0.00 H ATOM 11599 P CYT 3 0.101 28.930 13.729 1.00 0.00 P ATOM 11600 O1P CYT 3-0.422 27.549 13.835 1.00 0.00 0 ATOM 11601 02P CYT 3-0.124 29.710 12.491 1.00 0.00 0 ATOM 11602 05'CYT 3 1.685 28.891 14.024 1.00 0.00 O ATOM 11603 C5'CYT 3 2.536 29.956 13.590 1.00 0.00 C ATOM 11604 C4'CYT 3 3.986 29.726 14.008 1.00 0.00 C ATOM 11605 04'CYT 3 4.131 29.688 15.437 1.00 0.00 0 ATOM 11606 Cl'CYT 3 4.982 28.583 15.801 1.00 0.00 C ATOM 11607 N1 CYT 3 4.204 27.489 16.425 1.00 0.00 N ATOM 11608 C6 CYT 3 2.910 27.255 16. 060 1.00 0.00 C ATOM 11609 C2 CYT 3 4.834 26.713 17. 390 1.00 0.00 C ATOM 11610 02 CYT 3 6.005 26.933 17.696 1.00 0.00 O ATOM 11611 N3 CYT 3 4.125 25.707 17.971 1.00 0.00 N

ATOM 11612 C4 CYT 3 2.854 25.469 17. 621 1.00 0.00 C ATOM 11613 N4 CYT 3 2.186 24.481 18.213 1.00 0.00 N ATOM 11614 C5 CYT 3 2.204 26.263 16. 626 1.00 0.00 C ATOM 11615 C2'CYT 3 5. 625 28.123 14. 501 1.00 0.00 C ATOM 11616 02'CYT 3 6.782 28.905 14.179 1.00 0.00 O ATOM 11617 C3'CYT 3 4.492 28.373 13.530 1.00 0.00 C ATOM 11618 03'CYT 3 5.032 28.515 12.213 1.00 0.00 O ATOM 11619 1H5'CYT 3 2.185 30.893 14.025 1.00 0.00 H ATOM 11620 2H5'CYT 3 2.487 30.028 12.503 1.00 0.00 H ATOM 11621 H4'CYT 3 4.616 30.516 13.603 1.00 0.00 H ATOM 11622 Hl'CYT 3 5.754 28.926 16.491 1.00 0.00 H ATOM 11623 H6 CYT 3 2.442 27. 881 15.301 1.00 0.00 H ATOM 11624 1H4 CYT 3 1.227 24.296 17.959 1.00 0.00 H ATOM 11625 2H4 CYT 3 2.640 23.916 18.916 1.00 0.00 H ATOM 11626 H5 CYT 3 1.174 26.068 16.332 1.00 0.00 H ATOM 11627 H2'CYT 3 5.865 27.058 14.549 1.00 0.00 H ATOM 11628 H02'CYT 3 6.963 28.775 13.245 1.00 0.00 H ATOM 11629 H3'CYT 3 3.723 27.600 13.593 1.00 0.00 H ATOM 11630 P GUA 4 5.043 27.262 11.200 1.00 0.00 P ATOM 11631 01P GUA 4 5.635 27.708 9.920 1.00 0.00 O ATOM 11632 02P GUA 4 3.699 26.642 11.215 1.00 0. 00 0 ATOM 11633 05'GUA 4 6.073 26.247 11.909 1.00 0.00 O ATOM 11634 C5'GUA 4 7.481 26. 496 11.867 1.00 0.00 C ATOM 11635 C4'GUA 4 8.244 25.606 12.845 1.00 0.00 C ATOM 11636 04'GUA 4 7.783 25.772 14.192 1.00 0.00 0 ATOM 11637 Cl'GUA 4 7.791 24.492 14.857 1.00 0.00 C ATOM 11638 N9 GUA 4 6.425 24.061 15.217 1.00 0.00 N ATOM 11639 C4 GUA 4 6.090 23.067 16.109 1.00 0.00 C ATOM 11640 N3 GUA 4 6.959 22.312 16.818 1.00 0.00 N ATOM 11641 C2 GUA 4 6.337 21.425 17.600 1.00 0. 00 C ATOM 11642 N2 GUA 4 7.048 20.594 18.361 1.00 0.00 N ATOM 11643 N1 GUA 4 4.963 21.300 17.673 1.00 0.00 N ATOM 11644 C6 GUA 4 4.052 22.064 16. 956 1.00 0.00 C ATOM 11645 06 GUA 4 2.846 21.880 17.099 1.00 0.00 0 ATOM 11646 C5 GUA 4 4.705 23.008 16.121 1.00 0.00 C ATOM 11647 N7 GUA 4 4.164 23.953 15.245 1.00 0.00 N ATOM 11648 C8 GUA 4 5. 226 24.510 14.771 1.00 0.00 C ATOM 11649 C2'GUA 4 8.424 23.513 13.874 1.00 0.00 C ATOM 11650 02'GUA 4 9.848 23.460 14.028 1.00 0.00 0 ATOM 11651 C3'GUA 4 8.026 24.133 12.552 1.00 0.00 C ATOM 11652 03'GUA 4 8.952 23.717 11.544 1.00 0.00 0 ATOM 11653 1H5'GUA 4 7.666 27.540 12.120 1.00 0.00 H ATOM 11654 2H5'GUA 4 7.844 26.305 10.857 1.00 0.00 H ATOM 11655 H4'GUA 4 9.307 25.836 12. 799 1.00 0.00 H ATOM 11656 HI'GUA 4 8.404 24.553 15.757 1.00 0.00 H ATOM 11657 1H2 GUA 4 8.057 20.635 18.348 1.00 0.00 H ATOM 11658 2H2 GUA 4 6.578 19. 917 18.946 1.00 0.00 H ATOM 11659 H1 GUA 4 4.568 20. 603 18.287 1.00 0.00 H ATOM 11660 H8 GUA 4 5.162 25.303 14.028 1.00 0.00 H ATOM 11661 H2'GUA 4 7.977 22.522 13.983 1.00 0. 00 H ATOM 11662 H02'GUA 4 10.031 22.934 14.810 1.00 0.00 H ATOM 11663 H3'GUA 4 6.988 23.912 12.293 1.00 0.00 H ATOM 11664 P CYT 5 8.806 22. 270 10.851 1.00 0.00 P ATOM 11665 01P CYT 5 7.367 22. 006 10.627 1.00 0.00 0 ATOM 11666 02P CYT 5 9.753 22. 203 9.716 1.00 0.00 0 ATOM 11667 05'CYT 5 9. 327 21. 274 12.004 1.00 0.00 0 ATOM 11668 C5'CYT 5 10.708 21. 252 12. 376 1.00 0.00 C ATOM 11669 C4'CYT 5 10.970 20. 264 13.509 1.00 0.00 C ATOM 11670 04'CYT 5 10.215 20.590 14. 682 1.00 0.00 O ATOM 11671 C1'CYT 5 9.741 19. 376 15.300 1.00 0.00 C

ATOM 11672 N1 CYT 5 8.265 19.301 15.287 1.00 0.00 N ATOM 11673 C6 CYT 5 7.540 19.924 14.314 1.00 0.00 C ATOM 11674 C2 CYT 5 7.649 18.564 16.291 1.00 0.00 C ATOM 11675 02 CYT 5 8.325 18.011 17.157 1.00 0.00 0 ATOM 11676 N3 CYT 5 6.292 18.475 16.284 1.00 0.00 N ATOM 11677 C4 CYT 5 5.568 19.082 15.336 1.00 0.00 C ATOM 11678 N4 CYT 5 4.241 18.972 15.362 1.00 0.00 N ATOM 11679 C5 CYT 5 6.199 19.842 14.300 1.00 0.00 C ATOM 11680 C2'CYT 5 10.346 18.228 14.498 1.00 0.00 C ATOM 11681 02'CYT 5 11.600 17.808 15.048 1.00 0.00 0 ATOM 11682 C3'CYT 5 10.518 18.865 13.135 1.00 0.00 C ATOM 11683 03'CYT 5 11.586 18.205 12.447 1.00 0.00 0 ATOM 11684 1H5'CYT 5 11.006 22.250 12.699 1.00 0.00 H ATOM 11685 2H5'CYT 5 11.305 20.966 11.510 1.00 0.00 H ATOM 11686 H4'CYT 5 12.031 20.255 13.753 1.00 0.00 H ATOM 11687 Hl'CYT 5 10.099 19.328 16.329 1.00 0.00 H ATOM 11688 H6 CYT 5 8.053 20.493 13.539 1.00 0.00 H ATOM 11689 1H4 CYT 5 3.794 18.436 16.092 1.00 0.00 H ATOM 11690 2H4 CYT 5 3.682 19.422 14.651 1.00 0.00 H ATOM 11691 H5 CYT 5 5.615 20.336 13.527 1.00 0.00 H ATOM 11692 H2'CYT 5 9.639 17.396 14.443 1.00 0.00 H ATOM 11693 H02'CYT 5 12.219 17.735 14.319 1.00 0.00 H ATOM 11694 H3'CYT 5 9.587 18.870 12.565 1.00 0.00 H ATOM 11695 P URI 6 11.289 16.937 11.497 1.00 0.00 P ATOM 11696 01P URI 6 10.086 17.235 10.687 1.00 0.00 0 ATOM 11697 02P URI 6 12.553 16.556 10.827 1.00 0.00 O ATOM 11698 05'URI 6 10.911 15.785 12.556 1.00 0.00 0 ATOM 11699 C5'URI 6 11.897 15.275 13.458 1.00 0.00 C ATOM 11700 C4'URI 6 11.264 14.504 14.613 1.00 0.00 C ATOM 11701 04'URI 6 10. 295 15. 296 15.313 1.00 0.00 0 ATOM 11702 C1'URI 6 9.150 14.480 15.634 1.00 0.00 C ATOM 11703 N1 URI 6 7.948 14.908 14.879 1.00 0.00 N ATOM 11704 C6 URI 6 8.061 15.554 13.676 1.00 0.00 C ATOM 11705 C2 URI 6 6.710 14.635 15.437 1.00 0.00 C ATOM 11706 02 URI 6 6.589 14.052 16. 513 1.00 0.00 0 ATOM 11707 N3 URI 6 5.610 15.052 14.711 1.00 0.00 N ATOM 11708 C4 URI 6 5.636 15.709 13.494 1.00 0.00 C ATOM 11709 04 URI 6 4.591 16.035 12.937 1.00 0.00 0 ATOM 11710 C5 URI 6 6.967 15.953 12.985 1.00 0.00 C ATOM 11711 C2'URI 6 9.546 13.054 15.274 1.00 0.00 C ATOM 11712 02'URI 6 10.205 12.402 16.367 1.00 0.00 0 ATOM 11713 C3'URI 6 10.489 13.296 14.116 1.00 0.00 C ATOM 11714 03'URI 6 11.385 12.186 14.008 1.00 0.00 0 ATOM 11715 1H5'URI 6 12.474 16.107 13.862 1.00 0.00 H ATOM 11716 2H5'URI 6 12.568 14.611 12.913 1.00 0.00 H ATOM 11717 H4'URI 6 12.037 14.183 15.308 1.00 0.00 H ATOM 11718 H1'URI 6 8.948 14.540 16.703 1.00 0.00 H ATOM 11719 H6 URI 6 9.051 15.749 13.265 1.00 0.00 H ATOM 11720 H3 URI 6 4.702 14.860 15.107 1.00 0.00 H ATOM 11721 H5 URI 6 7.091 16.467 12.031 1.00 0.00 H ATOM 11722 H2'URI 6 8.672 12.489 14.948 1.00 0.00 H ATOM 11723 H02'URI 6 10.904 12.987 16.668 1.00 0.00 H ATOM 11724 H3'URI 6 9.954 13.502 13.187 1.00 0.00 H ATOM 11725 P CYT 7 11.023 10.930 13.066 1.00 0.00 P ATOM 11726 01P CYT 7 12.145 9.966 13.126 1.00 0.00 O ATOM 11727 02P CYT 7 10.566 11.449 11.757 1.00 0.00 0 ATOM 11728 05'CYT 7 9.756 10.278 13.818 1.00 0.00 O ATOM 11729 C5'CYT 7 9.895 9.717 15.126 1.00 0.00 C ATOM 11730 C4'CYT 7 8.543 9.559 15.817 1.00 0.00 C ATOM 11731 04'CYT 7 7.829 10.800 15.860 1.00 0.00 O

ATOM 11732 Cl'CYT 7 6.430 10.563 15.618 1.00 0.00 C ATOM 11733 N1 CYT 7 5.970 11.231 14.379 1.00 0.00 N ATOM 11734 C6 CYT 7 6.855 11.628 13.417 1.00 0.00 C ATOM 11735 C2 CYT 7 4.606 11.446 14.240 1.00 0.00 C ATOM 11736 02 CYT 7 3.829 11.073 15.117 1.00 0.00 0 ATOM 11737 N3 CYT 7 4.162 12. 069 13.116 1.00 0.00 N ATOM 11738 C4 CYT 7 5.017 12.466 12.165 1.00 0.00 C ATOM 11739 N4 CYT 7 4.546 13.078 11.079 1.00 0.00 N ATOM 11740 C5 CYT. 7 6.423 12.245 12.301 1.00 0.00 C ATOM 11741 C2'CYT 7 6.262 9.049 15.525 1.00 0.00 C ATOM 11742 02'CYT 7 5.936 8.484 16.800 1.00 0.00 0 ATOM 11743 C3'CYT 7 7.635 8.611 15.053 1.00 0.00 C ATOM 11744 03'CYT 7 7.876 7.276 15.517 1.00 0.00 O ATOM 11745 1H5'CYT 7 10.526 10.371 15.729 1.00 0.00 H ATOM 11746 2H5'CYT 7 10.370 8.739 15.046 1.00 0.00 H ATOM 11747 H4'CYT 7 8.688 9.191 16.832 1.00 0.00 H ATOM 11748 H1'CYT 7 5.851 10.936 16.464 1.00 0.00 H ATOM 11749 H6 CYT 7 7.920 11.441 13.552 1.00 0.00 H ATOM 11750 1H4 CYT 7 5. 182' 13.385 10.357 1.00 0.00 H ATOM 11751 2H4 CYT 7 3.553 13.233 10.977 1.00 0.00 H ATOM 11752 H5 CYT 7 7.122 12.567 11.529 1.00 0.00 H ATOM 11753 H2'CYT 7 5.504 8.798 14.778 1.00 0.00 H ATOM 11754 H02'CYT 7 5.042 8.760 17.014 1.00 0. 00 H ATOM 11755 H3'CYT 7 7.749 8.710 13.972 1.00 0.00 H ATOM 11756 P ADE 8 7.455 6.000 14.627 1.00 0.00 P ATOM 11757 O1P ADE 8 7.728 4.776 15.413 1.00 0.00 0 ATOM 11758 02P ADE 8 8.050 6.158 13.281 1.00 0.00 0 ATOM 11759 05'ADE 8 5.859 6. 169 14.493 1.00 0.00 O ATOM 11760 C5'ADE 8 5.016 6.121 15.649 1.00 0.00 C ATOM 11761 C4'ADE 8 3.576 6.497 15.308 1.00 0.00 C ATOM 11762 04'ADE 8 3.503 7.789 14.680 1.00 0.00 0 ATOM 11763 C1'ADE 8 2. 718 7.692 13.477 1.00 0.00 C ATOM 11764 N9 ADE 8 3.575 7.693 12.273 1.00 0.00 N ATOM 11765 C4 ADE 8 3.173 7.906 10.970 1.00 0.00 C ATOM 11766 N3 ADE 8 1.918 8. 167 10.548 1.00 0.00 N ATOM 11767 C2 ADE 8 1.874 8.322 9.226 1.00 0.00 C ATOM 11768 N1 ADE 8 2.895 8.243 8.370 1.00 0.00 N ATOM 11769 C6 ADE 8 4.136 7.981 8.815 1.00 0.00 C ATOM 11770 N6 ADE 8 5.141 7.904 7.943 1.00 0.00 N ATOM 11771 C5 ADE 8 4.303 7.800 10.192 1.00 0.00 C ATOM 11772 N7 ADE 8 5.425 7. 522 10.979 1.00 0.00 N ATOM 11773 C8 ADE 8 4.909 7.479 12.161 1.00 0.00 C ATOM 11774 C2'ADE 8 1.950 6.390 13.606 1.00 0.00 C ATOM 11775 02'ADE 8 0.769 6.550 14.402 1.00 0.00 0 ATOM 11776 C3'ADE 8 2.981 5.527 14.297 1.00 0.00 C ATOM 11777 03'ADE 8 2.311 4.473 14.997 1.00 0.00 0 ATOM 11778 1H5'ADE 8 5.397 6.814 16.398 1.00 0.00 H ATOM 11779 2H5'ADE 8 5.033 5.111 16.059 1.00 0.00 H ATOM 11780 H4'ADE 8 2.972 6.501 16.214 1.00 0.00 H ATOM 11781 H1'ADE 8 2.019 8.521 13.429 1.00 0.00 H ATOM 11782 H2 ADE 8 0.896 8.538 8.792 1.00 0.00 H ATOM 11783 1H6 ADE 8 4.967 8.043 6.958 1.00 0.00 H ATOM 11784 2H6 ADE 8 6.077 7.706 8.268 1.00 0.00 H ATOM 11785 H8 ADE 8 5.524 7.284 13.039 1.00 0.00 H ATOM 11786 H2'ADE 8 1.712 5.991 12.618 1.00 0.00 H ATOM 11787 H02'ADE 8 0.480 5.673 14.663 1.00 0.00 H ATOM 11788 H3'ADE 8 3.729 5.157 13.599 1.00 0. 00 H ATOM 11789 P ADE 9 3.079 3.096 15.330 1.00 0.00 P ATOM 11790 01P ADE 9 4.154 3.386 16.305 1.00 0.00 0 ATOM 11791 02P ADE 9 2.065 2.062 15.636 1.00 0.00 0

ATOM 11792 05'ADE 9 3.764 2.726 13.917 1.00 0.00 0 ATOM 11793 C5'ADE 9 4.429 1.471 13.728 1.00 0.00 C ATOM 11794 C4'ADE 9 5.097 1.384 12.354 1.00 0.00 C ATOM 11795 04'ADE 9 4.160 1.634 11.303 1.00 0.00 0 ATOM 11796 C1'ADE 9 4.372 2.952 10.769 1.00 0.00 C ATOM 11797 N9 ADE 9 3.099 3.688 10.683 1.00 0.00 N ATOM 11798 C4 ADE 9 2. 578 4.295 9.568 1.00 0.00 C ATOM 11799 N3 ADE 9 3.154 4.358 8.356 1.00 0.00 N ATOM 11800 C2 ADE 9 2.389 5.012 7.493 1.00 0.00 C ATOM 11801 N1 ADE 9 1.197 5.564 7.725 1.00 0.00 N ATOM 11802 C6 ADE 9 0.641 5.488 8.946 1.00 0.00 C ATOM 11803 N6 ADE 9-0.553 6.043 9.157 1.00 0.00 N ATOM 11804 C5 ADE 9 1.361 4.817 9.939 1.00 0.00 C ATOM 11805 N7 ADE 9 1.097 4.551 11.285 1.00 0.00 N ATOM 11806 C8 ADE 9 2.155 3.897 11.631 1.00 0.00 C ATOM 11807 C2'ADE 9 5.350 3.636 11.717 1.00 0.00 C ATOM 11808 02'ADE 9 6.157 4.609 11.041 1.00 0.00 O ATOM 11809 C3'ADE 9 6.168 2.453 12.185 1.00 0.00 C ATOM 11810 03'ADE 9 7.043 2.077 11.111 1.00 0.00 0 ATOM 11811 1H5'ADE 9 3.699 0.666 13.819 1.00 0.00 H ATOM 11812 2H5'ADE 9 5.188 1.350 14.501 1.00 0.00 H ATOM 11813 H4'ADE 9 5.533 0.396 12.221 1.00 0.00 H ATOM 11814 H1'ADE 9 4.821 2.878 9.777 1.00 0.00 H ATOM 11815 H2 ADE 9 2.774 5.098 6.482 1.00 0.00 H ATOM 11816 1H6 ADE 9-0.979 5.989 10.071 1.00 0.00 H ATOM 11817 2H6 ADE 9-1.031 6.515 8.403 1.00 0.00 H ATOM 11818 H8 ADE 9 2. 288 3.534 12.648 1.00 0.00 H ATOM 11819 H2'ADE 9 4.818 4.076 12.559 1.00 0.00 H ATOM 11820 H02'ADE 9 5.589 5.354 10.831 1.00 0.00 H ATOM 11821 H3'ADE 9 6.699 2.656 13.110 1.00 0.00 H ATOM 11822 P URI 10 7.925 0.727 11.151 1.00 0.00 P ATOM 11823 01P URI 10 9.220 1.037 11.797 1.00 0.00 0 ATOM 11824 02P URI 10 7.085-0. 376 11.670 1.00 0.00 0 ATOM 11825 05'URI 10 8.191 0.469 9.583 1.00 0.00 0 ATOM 11826 C5'URI 10 8.064-0. 836 9.010 1.00 0.00 C ATOM 11827 C4'URI 10 6.992-0. 860 7.919 1.00 0.00 C ATOM 11828 04'URI 10 7.081 0.282 7.063 1.00 0.00 0 ATOM 11829 C1'URI 10 7.768-0. 071 5.847 1.00 0.00 C ATOM 11830 N1 URI 10 8.942 0.805 5.638 1.00 0.00 N ATOM 11831 C6 URI 10 9.377 1.645 6.630 1.00 0.00 C ATOM 11832 C2 URI 10 9.582 0.745 4.411 1.00 0.00 C ATOM 11833 02 URI 10 9.203 0.004 3.506 1.00 0.00 0 ATOM 11834 N3 URI 10 10.677 1.577 4.257 1.00 0.00 N ATOM 11835 C4 URI 10 11.180 2.450 5.206 1.00 0.00 C ATOM 11836 04 URI 10 12.163 3.144 4.959 1.00 0.00 0 ATOM 11837 C5 URI 10 10.451 2.448 6.454 1.00 0.00 C ATOM 11838 C2'URI 10 8.189-1. 535 6.001 1.00 0.00 C ATOM 11839 02'URI 10 8. 117-2. 240 4.757 1.00 0.00 0 ATOM 11840 C3'URI 10 7.167-2. 054 6.997 1.00 0.00 C ATOM 11841 03'URI 10 5.931-2. 281 6.307 1.00 0.00 O ATOM 11842 1H5'URI 10 7.796-1. 550 9.789 1.00 0.00 H ATOM 11843 2H5'URI 10 9.021-1. 126 8.576 1.00 0.00 H ATOM 11844 H4'URI 10 6. 006-0. 891 8.377 1.00 0.00 H ATOM 11845 H1'URI 10 7.087 0.025 5.002 1.00 0.00 H ATOM 11846 H6 URI 10 8.842 1.672 7.580 1.00 0.00 H ATOM 11847 H3 URI 10 11.154 1.544 3.368 1.00 0.00 H ATOM 11848 H5 URI 10 10.770 3.101 7.265 1. 00 0.00 H ATOM 11849 H2'URI 10 9.193-1. 594 6.431 1.00 0.00 H ATOM 11850 H02'URI 10 7.224-2. 133 4.419 1.00 0.00 H ATOM 11851 H3'URI 10 7.518-2. 939 7.529 1.00 0.00 H

ATOM 11852 P GUA 11 4.701-3. 024 7.038 1.00 0.00 P ATOM 11853 01P GUA 11 5. 227-4. 224 7.727 1.00 0.00 O ATOM 11854 02P GUA 11 3.596-3. 159 6, 062 1.00 0.00 O ATOM 11855 05'GUA 11 4.256-1. 952 8.156 1.00 0.00 O ATOM 11856 C5'GUA 11 3.717-2. 384 9.409 1.00 0. 00 C ATOM 11857 C4'GUA 11 2.535-1. 521 9.840 1.00 0.00 C ATOM 11858 04'GUA 11 2. 906-0.140 9.960 1.00 0.00 0 ATOM 11859 Cl'GUA 11 1.921 0.680 9.305 1.00 0.00 C ATOM 11860 N9 GUA 11 2.429 1.201 8.024 1.00 0.00 N ATOM 11861 C4 GUA 11 1.742 1.990 7.133 1.00 0.00 C ATOM 11862 N3 GUA 11 0.471 2.426 7.279 1.00 0.00 N ATOM 11863 C2 GUA 11 0.075 3.178 6.251 1.00 0.00 C ATOM 11864 N2 GUA 11-1.155 3.691 6.237 1.00 0.00 N ATOM 11865 N1 GUA 11 0.875 3. 472 5.165 1.00 0.00 N ATOM 11866 C6 GUA 11 2.182 3.037 4.992 1.00 0.00 C ATOM 11867 06 GUA 11 2.811 3.358 3.987 1.00 0.00 0 ATOM 11868 C5 GUA 11 2.612 2.237 6.082 1.00 0.00 C ATOM 11869 N7 GUA 11 3.841 1.608 6.304 1.00 0.00 N ATOM 11870 C8 GUA 11 3.640 1.038 7. 444. 1.00 0.00 C ATOM 11871 C2'GUA 11 0.723-0. 232 9.083 1.00 0.00 C ATOM 11872 02'GUA 11-0.103-0. 313 10.251 1.00 0.00 O ATOM 11873 C3'GUA 11 1.428-1. 541 8.798 1.00 0.00 C ATOM 11874 03'GUA 11 0.538-2. 623 9.086 1.00 0.00 O ATOM 11875 1H5'GUA 11 4.496-2. 325 10.170 1.00 0.00 H ATOM 11876 2H5'GUA 11 3.386-3. 419 9.319 1.00 0.00 H ATOM 11877 H4'GUA 11 2.148-1. 875 10.794 1.00 0.00 H ATOM 11878 H1'GUA 11 1.642 1.514 9.953 1.00 0.00 H ATOM 11879 1H2 GUA 11-1.456 4. 260 5.460 1.00 0.00 H ATOM 11880 2H2 GUA 11-1.786 3.510 7.005 1.00 0.00 H ATOM 11881 H1 GUA 11 0.499 4.049 4.427 1.00 0.00 H ATOM 11882 H8 GUA 11 4.415 0.445 7. 924 1.00 0.00 H ATOM 11883 H2'GUA 11 0.149 0.095 8.211 1.00 0.00 H ATOM 11884 H02'GUA 11-0. 545 0.533 10.347 1.00 0.00 H ATOM 11885 H3'GUA 11 1.822-1. 578 7.781 1.00 0.00 H ATOM 11886 P CYT 12-0.183-3. 418 7.887 1.00 0.00 P ATOM 11887 01P CYT 12-1.083-4. 434 8. 476 1.00 0.00 0 ATOM 11888 02P CYT 12 0. 853-3. 827 6.911 1.00 0.00 0 ATOM 11889 05'CYT 12-1.088-2. 273 7.209 1.00 0.00 0 ATOM 11890 C5'CYT 12-2.276-1. 810 7.856 1.00 0.00 C ATOM 11891 C4'CYT 12-3.032-0. 807 6.991 1.00 0.00 C ATOM 11892 04'CYT 12-2.264 0.376 6.750 1.00 0.00 0 ATOM 11893 C1'CYT 12-2.499 0.830 5.401 1.00 0.00 C ATOM 11894 N1 CYT 12-1.254 0.805 4.598 1.00 0.00 N ATOM 11895 C6 CYT 12-0.142 0.142 5.037 1.00 0.00 C ATOM 11896 C2 CYT 12-1. 253 1.500 3.395 1.00 0. 00 C ATOM 11897 02 CYT 12-2.271 2.073 3.010 1.00 0.00 O ATOM 11898 N3 CYT 12-0.110 1.514 2. 658 1.00 0.00 N ATOM 11899 C4 CYT 12 0.988 0.873 3.077 1.00 0.00 C ATOM 11900 N4 CYT 12 2.096 0.922 2.338 1.00 0.00 N ATOM 11901 C5 CYT 12 0.992 0.150 4.311 1.00 0.00 C ATOM 11902 C2'CYT 12-3.555-0. 105 4.815 1.00 0.00 C ATOM 11903 02'CYT 12-4. 877 0.405 5.021 1.00 0.00 0 ATOM 11904 C3'CYT 12-3.311-1. 369 5.611 1.00 0. 00 C ATOM 11905 03'CYT 12-4.521-2. 131 5.662 1.00 0. 00 O ATOM 11906 1H5'CYT 12-2.007-1. 335 8.800 1.00 0.00 H ATOM 11907 2H5'CYT 12-2.924-2. 662 8.059 1.00 0.00 H ATOM 11908 H4'CYT 12-3.970-0. 536 7.475 1.00 0.00 H ATOM 11909 H1'CYT 12-2.892 1.847 5.427 1. 00 0.00 H ATOM 11910 H6 CYT 12-0.171-0. 396 5.984 1. 00 0.00 H ATOM 11911 1H4 CYT 12 2.932 0. 450 2.651 1. 00 0.00 H

ATOM 11912 2H4 CYT 12 2.100 1.434 1.468 1.00 0.00 H ATOM 11913 H5 CYT 12 1.882-0. 379 4.651 1.00 0.00 H ATOM 11914 H2'CYT 12-3.360-0. 277 3.755 1.00 0.00 H ATOM 11915 H02'CYT 12-4.951 1.215 4.510 1.00 0.00 H ATOM 11916 H3'CYT 12-2.468-1. 941 5.219 1.00 0.00 H ATOM 11917 P URI 13-4.670-3. 481 4.798 1.00 0.00 P ATOM 11918 01P URI 13-3.355-4. 160 4.767 1.00 0.00 0 ATOM 11919 02P URI 13-5.865-4. 209 5.278 1.00 0.00 0 ATOM 11920 05'URI 13-4.980-2. 916 3.323 1.00 0.00 0 ATOM 11921 C5'URI 13-6.276-2. 405 2.999 1.00 0.00 C ATOM 11922 C4'URI 13-6.265-1. 634 1.682 1.00 0.00 C ATOM 11923 04'URI 13-5.371-0. 517 1.730 1.00 0.00 0 ATOM 11924 C1'URI 13-4.717-0. 374 0.453 1.00 0.00 C ATOM 11925 N1 URI 13-3. 252-0.559 0.568 1.00 0.00 N ATOM 11926 C6 URI 13-2.705-1. 290 1.591 1.00 0.00 C ATOM 11927 C2 URI 13-2.459 0.030-0. 402 1.00 0.00 C ATOM 11928 02 URI 13-2.932 0.690-1. 325 1.00 0.00 0 ATOM 11929 N3 URI 13-1. 099-0. 166-0.274 1.00 0.00 N ATOM 11930 C4 URI 13-0.466-0. 886 0.722 1.00 0.00 C ATOM 11931 04 URI 13 0.758-0. 990 0.737 1.00 0.00 0 ATOM 11932 C5 URI 13-1.366-1. 466 1.692 1.00 0.00 C ATOM 11933 C2'URI 13-5.331-1. 433-0.460 1.00 0.00 C ATOM 11934 02'URI 13-6.456-0. 917-1.183 1.00 0.00 0 ATOM 11935 C3'URI 13-5.747-2. 490 0.542 1.00 0.00 C ATOM 11936 03'URI 13-6.835-3. 243-0.004 1.00 0.00 O ATOM 11937 1H5'URI 13-6.607-1. 740 3.797 1.00 0.00 H ATOM 11938 2H5'URI 13-6.975-3. 237 2.917 1.00 0. 00 H ATOM 11939 H4'URI 13-7.270-1. 283 1.452 1.00 0.00 H ATOM 11940 H1'URI 13-4.927 0.617 0.049 1.00 0.00 H ATOM 11941 H6 URI 13-3.359-1. 739 2.339 1.00 0.00 H ATOM 11942 H3 URI 13-0.510 0.254-0. 978 1.00 0.00 H ATOM 11943 H5 URI 13-0.962-2. 053 2.517 1.00 0.00 H ATOM 11944 H2'URI 13-4.575-1. 830-1.141 1.00 0.00 H ATOM 11945 H02'URI 13-6.113-0. 337-1.867 1.00 0.00 H ATOM 11946 H3'URI 13-4. 908-3. 118 0.846 1.00 0.00 H ATOM 11947 P CYT 14-6.556-4. 585-0. 850 1.00 0.00 P ATOM 11948 01P CYT 14-7.860-5. 204-1.180 1.00 0.00 0 ATOM 11949 02P CYT 14-5.524-5. 375-0.141 1.00 0.00 0 ATOM 11950 05'CYT 14-5.907-4. 017-2. 211 1.00 0.00 0 ATOM 11951 C5'CYT 14-6.735-3. 481-3.248 1.00 0.00 C ATOM 11952 C4'CYT 14-5.906-3. 004-4. 438 1.00 0.00 C ATOM 11953 04'CYT 14-4.998-1. 962-4.064 1.00 0.00 0 ATOM 11954 C1'CYT 14-3. 734-2. 160-4. 727 1.00 0.00 C ATOM 11955 N1 CYT 14-2. 653-2. 442-3.760 1.00 0.00 N ATOM 11956 C6 CYT 14-2.912-3. 083-2.584 1.00 0.00 C ATOM 11957 C2 CYT 14-1.369-2. 034-4.095 1.00 0. 00 C ATOM 11958 02 CYT 14-1.158-1. 464-5.165 1.00 0.00 0 ATOM 11959 N3 CYT 14-0.362-2. 289-3.218 1.00 0.00 N ATOM 11960 C4 CYT 14-0.601-2. 917-2. 061 1.00 0.00 C ATOM 11961 N4 CYT 14 0.410-3. 151-1.227 1.00 0.00 N ATOM 11962 C5 CYT 14-1. 922-3. 339-1.711 1.00 0.00 C ATOM 11963 C2'CYT 14-3.931-3. 334-5.678 1.00 0.00 C ATOM 11964 02'CYT 14-4.345-2. 893-6. 977 1.00 0.00 0 ATOM 11965 C3'CYT 14-5.024-4. 116-4.978 1.00 0.00 C ATOM 11966 03'CYT 14-5.757-4. 853-5.962 1.00 0.00 0 ATOM 11967 1H5'CYT 14-7.305-2. 641-2.852 1.00 0.00 H ATOM 11968 2H5'CYT 14-7.427-4. 254-3.584 1.00 0.00 H ATOM 11969 H4'CYT 14-6.566-2. 642-5. 226 1.00 0.00 H ATOM 11970 H1'CYT 14-3. 483-1.269-5. 302 1. 00. 0.00 H ATOM 11971 H6 CYT 14-3.930-3. 394-2.350 1.00 0.00 H

ATOM 11972 1H4 CYT 14 0.243-3. 625-0.350 1.00 0. 00 H ATOM 11973 2H4 CYT 14 1.345-2. 861-1.474 1.00 0.00 H ATOM 11974 H5 CYT 14-2.118-3. 856-0.774 1. 00 0.00 H ATOM 11975 H2'CYT 14-3.015-3. 929-5.736 1.00 0.00 H ATOM 11976 H02'CYT 14-4.899-3. 583-7.349 1.00 0.00 H ATOM 11977 H3'CYT 14-4.628-4. 751-4.184 1.00 0. 00 H ATOM 11978 P URI 15-5.324-6. 357-6.343 1.00 0.00 P ATOM 11979 01P URI 15-5.384-7. 180-5.114 1.00 0.00 O ATOM 11980 02P URI 15-6.084-6. 767-7.544 1.00 0.00 0 ATOM 11981 05'URI 15-3.776-6. 183-6.756 1.00 0.00 0 ATOM 11982 C5'URI 15-3.411-5. 690-8.050 1.00 0.00 C ATOM 11983 C4'URI 15-1.896-5. 575-8.201 1.00 0.00 C ATOM 11984 04'URI 15-1.339-4. 637-7.268 1.00 0.00 0 ATOM 11985 C1'URI 15-0. 150-5.193-6. 673 1.00 0.00 C ATOM 11986 N1 URI 15-0.372-5. 524-5.249 1.00 0. 00 N ATOM 11987 C6 URI 15-1.572-6. 024-4.823 1.00 0.00 C ATOM 11988 C2 URI 15 0.679-5. 321-4.371 1.00 0.00 C ATOM 11989 02 URI 15 1. 764-4.873-4. 735 1.00 0.00 0 ATOM 11990 N3 URI 15 0.438-5. 656-3.051 1.00 0.00 N ATOM 11991 C4 URI 15-0.741-6. 167-2.540 1.00 0. 00 C ATOM 11992 04 URI 15-0.843-6. 429-1.344 1.00 0.00 O ATOM 11993 C5 URI 15-1.782-6. 345-3.527 1.00 0.00 C ATOM 11994 C2'URI 15 0.175-6. 444-7.484 1.00 0.00 C ATOM 11995 02'URI 15 0.989-6. 136-8.622 1.00 0.00 0 ATOM 11996 C3'URI 15-1.212-6. 897-7.892 1.00 0.00 C ATOM 11997 03'URI 15-1.115-7. 651-9.104 1.00 0.00 0 ATOM 11998 1H5'URI 15-3.859-4. 707-8.198 1.00 0.00 H ATOM 11999 2H5'URI 15-3.792-6. 373-8.810 1.00 0.00 H ATOM 12000 H4'URI 15-1.650-5. 264-9.215 1.00 0.00 H ATOM 12001 H1'URI 15 0.669-4. 479-6.760 1.00 0.00 H ATOM 12002 H6 URI 15-2.379-6. 159-5.542 1.00 0.00 H ATOM 12003 H3 URI 15 1.196-5. 514-2.399 1.00 0.00 H ATOM 12004 H5 URI 15-2.747-6. 750-3.227 1.00 0.00 H ATOM 12005 H2'URI 15 0. 651-7.198-6. 849 1.00 0.00 H ATOM 12006 H02'URI 15 0.617-5. 355-9.036 1.00 0.00 H ATOM 12007 H3'URI 15-1. 716-7. 445-7.092 1.00 0.00 H ATOM 12008 P URI 16-0.620-9. 182-9.082 1.00 0.00 P ATOM 12009 01P URI 16-0.838-9. 758-10.428 1.00 0.00 0 ATOM 12010 02P URI 16-1.205-9. 843-7.893 1.00 0.00 0 ATOM 12011 05'URI 16 0.967-9. 035-8.847 1.00 0.00 0 ATOM 12012 C5'URI 16 1.833-10. 163-9.001 1.00 0.00 C ATOM 12013 C4'URI 16 2. 877-9.927-10. 082 1.00 0.00 C ATOM 12014 04'URI 16 2.273-9. 466-11.300 1.00 0.00 O ATOM 12015 C1'URI 16 2.927-8. 271-11.733 1.00 0.00 C ATOM 12016 N1 URI 16 1.989-7. 373-12.441 1.00 0.00 N ATOM 12017 C6 URI 16 0.815-6. 977-11.855 1.00 0.00 C ATOM 12018 C2 URI 16 2.339-6. 951-13.712 1.00 0.00 C ATOM 12019 02 URI 16 3. 388-7. 296-14. 253 1.00 0.00 0 ATOM 12020 N3 URI 16 1.437-6. 115-14.344 1.00 0.00 N ATOM 12021 C4 URI 16 0.234-5. 669-13.826 1.00 0.00 C ATOM 12022 04 URI 16-0.492-4. 924-14.481 1.00 0. 00 0 ATOM 12023 C5 URI 16-0. 052-6. 157-12. 496 1. 00 0.00 C ATOM 12024 C2'URI 16 3.457-7. 628-10.464 1.00 0.00 C ATOM 12025 02'URI 16 4.568-6. 765-10.731 1.00 0.00 O ATOM 12026 C3'URI 16 3.871-8. 845-9.654 1.00 0.00 C ATOM 12027 03'URI 16 5.177-9. 254-10.071 1.00 0.00 0 ATOM 12028 lH5'URI 16 1.242-11. 034-9.257 1.00 0.00 H ATOM 12029 2H5'URI 16 2.341-10. 353-8.062 1.00 0.00 H ATOM 12030 H4'URI 16 3.413-10. 855-10.277 1.00 0. 00 H ATOM 12031 H1'URI 16 3.760-8. 527-12.389 1.00 0.00 H

ATOM 12032 H6 URI 16 0.573-7. 329-10.852 1.00 0.00 H ATOM 12033 H3 URI 16 1.680-5. 799-15.272 1.00 0. 00 H ATOM 12034 H5 URI 16-0.977-5. 861-12.002 1.00 0.00 H ATOM 12035 H2'URI 16 2.655-7. 092-9.949 1. 00 0. 00 H ATOM 12036 H02'URI 16 5.260-7. 304-11.122 1.00 0.00 H ATOM 12037 H3'URI 16 3.827-8. 654-8.581 1.00 0.00 H ATOM 12038 P CYT 17 5.938-10. 445-9.295 1.00 0.00 P ATOM 12039 01P CYT 17 5.113-11. 670-9.395 1.00 0.00 O ATOM 12040 02P CYT 17 7. 347-10. 467-9.747 1. 00 0.00 0 ATOM 12041 05'CYT 17 5. 904-9.938-7. 766 1.00 0.00 O ATOM 12042 C5'CYT 17 6.748-8. 863-7.348 1.00 0.00 C ATOM 12043 C4'CYT 17 6.451-8. 418-5.921 1. 00 0.00 C ATOM 12044 04'CYT 17 5.082-8. 014-5.775 1.00 0.00 O ATOM 12045 C1'CYT 17 4.533-8. 658-4.628 1. 00 0.00 C ATOM 12046 N1 CYT 17 3.074-8. 828-4.751 1.00 0.00 N ATOM 12047 C6 CYT 17 2.546-9. 542-5.777 1.00 0.00 C ATOM 12048 C2 CYT 17 2.266-8. 222-3.797 1.00 0.00 C ATOM 12049 02 CYT 17 2.769-7. 578-2.878 1.00 0.00 O ATOM 12050 N3 CYT 17 0.918-8. 361-3.913 1.00 0.00 N ATOM 12051 C4 CYT 17 0.384-9. 060-4.921 1. 00 0.00 C ATOM 12052 N4 CYT 17-0.941-9. 173-5.011 1.00 0.00 N ATOM 12053 C5 CYT 17 1.216-9. 683-5.903 1.00 0.00 C ATOM 12054 C2'CYT 17 5.257-9. 988-4.560 1.00 0. 00 C ATOM 12055 02'CYT 17 5.199-10. 560-3.248 1.00 0.00 0 ATOM 12056 C3'CYT 17 6.670-9. 564-4.931 1.00 0.00 C ATOM 12057 03'CYT 17 7.300-9. 031-3.759 1. 00 0.00 O ATOM 12058 1H5'CYT 17 6. 605-8.020-8. 016 1.00 0.00 H ATOM 12059 2H5'CYT 17 7.782-9. 190-7.406 1.00 0.00 H ATOM 12060 H4'CYT 17 7.101-7. 584-5.659 1.00 0.00 H ATOM 12061 Hl'CYT 17 4.759-8. 076-3.742 1. 00 0.00 H ATOM 12062 H6 CYT 17 3. 211-10. 011-6. 501 1.00 0.00 H ATOM 12063 1H4 CYT 17-1.354-9. 696-5.771 1.00 0.00 H ATOM 12064 2H4 CYT 17-1.533-8. 735-4.320 1.00 0.00 H ATOM 12065 H5 CYT 17 0.790-10. 241-6.731 1.00 0.00 H ATOM 12066 H2'CYT 17 4.861-10. 676-5.313 1.00 0.00 H ATOM 12067 H02'CYT 17 5.779-11. 324-3.244 1.00 0.00 H ATOM 12068 H3'CYT 17 7. 242-10. 377-5.376 1. 00 0.00 H ATOM 12069 P GUA 18 8.887-9. 197-3.529 1.00 0.00 P ATOM 12070 01P GUA 18 9.223-8. 632-2.203 1.00 0.00 0 ATOM 12071 02P GUA 18 9.259-10. 593-3.851 1.00 0.00 0 ATOM 12072 05'GUA 18 9.512-8. 236-4.662 1. 00 0.00 0 ATOM 12073 C5'GUA 18 9.442-6. 812-4.535 1.00 0.00 C ATOM 12074 C4'GUA 18 9.912-6. 114-5.808 1. 00 0. 00 C ATOM 12075 04'GUA 18 9.103-6. 475-6.928 1.00 0.00 0 ATOM 12076 C1'GUA 18 8.928-5. 338-7.791 1.00 0.00 C ATOM 12077 N9 GUA 18 7.496-5. 020-7.970 1.00 0.00 N ATOM 12078 C4 GUA 18 6.512-5. 052-7.003 1.00 0.00 C ATOM 12079 N3 GUA 18 6.689-5. 358-5.697 1.00 0.00 N ATOM 12080 C2 GUA 18 5.544-5. 307-5.007 1.00 0. 00 C ATOM 12081 N2 GUA 18 5.539-5. 585-3.704 1.00 0.00 N ATOM 12082 N1 GUA 18 4.326-4. 979-5.567 1.00 0.00 N ATOM 12083 C6 GUA 18 4.119-4. 661-6.903 1.00 0.00 C ATOM 12084 06 GUA 18 2.991-4. 382-7.303 1.00 0.00 O ATOM 12085 C5 GUA 18 5.330-4. 712-7.644 1.00 0.00 C ATOM 12086 N7 GUA 18 5.557-4. 465-9.000 1.00 0.00 N ATOM 12087 C8 GUA 18 6.828-4. 665-9.095 1.00 0.00 C ATOM 12088 C2'GUA 18 9. 684-4. 174-7. 147 1.00 0.00 C ATOM 12089 02'GUA 18 10.983-4. 011-7.730 1.00 0.00 0 ATOM 12090 C3'GUA 18 9. 777-4. 606-5. 692 1.00 0.00 C ATOM 12091 03'GUA 18 10. 992-4. 086-5. 140 1. 00 0.00 0

ATOM 12092 1H5'GUA 18 10.071-6. 496-3.703 1.00 0.00 H ATOM 12093 2H5'GUA 18 8.410-6. 523-4.331 1. 00 0.00 H ATOM 12094 H4'GUA 18 10.949-6. 376-6.012 1.00 0.00 H ATOM 12095 H1'GUA 18 9.371-5. 556-8.763 1.00 0.00 H ATOM 12096 1H2 GUA 18 4.675-5. 546-3.183 1.00 0.00 H ATOM 12097 2H2 GUA 18 6.399-5. 835-3.238 1.00 0.00 H ATOM 12098 H1 GUA 18 3.506-4. 964-4. 977 1.00 0.00 H ATOM 12099 H8 GUA 18 7.347-4. 552-10.048 1.00 0.00 H ATOM 12100 H2'GUA 18 9.101-3. 254-7. 231 1.00 0.00 H ATOM 12101 H02'GUA 18 10.854-3. 713-8.633 1.00 0.00 H ATOM 12102 H3'GUA 18 8. 895-4. 312-5.121 1.00 0.00 H ATOM 12103 P GUA 19 11.039-2. 618-4.478 1.00 0.00 P ATOM 12104 01P GUA 19 12. 452-2. 287-4.185 1.00 0.00 0 ATOM 12105 02P GUA 19 10.030-2. 567-3.396 1.00 0.00 O ATOM 12106 05'GUA 19 10.540-1. 670-5.683 1.00 0.00 O ATOM 12107 C5'GUA 19 9.585-0. 630-5.447 1.00 0.00 C ATOM 12108 C4'GUA 19 8.673-0. 422-6.654 1.00 0.00 C ATOM 12109 04'GUA 19 7. 976-1.633-6. 999 1.00 0.00 O ATOM 12110 C1'GUA 19 6.566-1. 362-7. 070 1.00 0.00 C ATOM 12111 N9 GUA 19 5.882-1. 772-5.827 1.00 0.00 N ATOM 12112 C4 GUA 19 4. 525-1. 763-5.592 1.00 0.00 C ATOM 12113 N3 GUA 19 3.568-1. 392-6.472 1.00 0.00 N ATOM 12114 C2 GUA 19 2.340-1. 490-5.953 1.00 0.00 C ATOM 12115 N2 GUA 19 1.278-1. 159-6.688 1.00 0.00 N ATOM 12116 N1 GUA 19 2.084-1. 920-4.666 1.00 0. 00 N ATOM 12117 C6 GUA 19 3.049-2. 305-3.746 1.00 0.00 C ATOM 12118 06 GUA 19 2.717-2. 674-2.622 1.00 0.00 0 ATOM 12119 C5 GUA 19 4.356-2. 205-4. 288 1.00 0.00 C ATOM 12120 N7 GUA 19 5.591-2. 492-3. 701 1.00 0.00 N ATOM 12121 C8 GUA 19 6. 408-2. 214-4.659 1.00 0.00 C ATOM 12122 C2'GUA 19 6.470 0.139-7. 269 1.00 0.00 C ATOM 12123 02'GUA 19 6.718 0.510-8. 631 1.00 0.00 0 ATOM 12124 C3'GUA 19 7.581 0.598-6. 350 1.00 0.00 C ATOM 12125 03'GUA 19 8.020 1.894-6. 768 1.00 0.00 0 ATOM 12126 1H5'GUA 19 10.115 0.299-5. 238 1.00 0.00 H ATOM 12127 2H5'GUA 19 8.977-0. 895-4.583 1.00 0.00 H ATOM 12128 H4'GUA 19 9.261-0. 088-7.507 1.00 0.00 H ATOM 12129 H1'GUA 19 6.130-1. 880-7.924 1.00 0.00 H ATOM 12130 1H2 GUA 19 1.402-0. 835-7.637 1.00 0.00 H ATOM 12131 2H2 GUA 19 0.350-1. 232-6.296 1.00 0.00 H ATOM 12132 Hl GUA 19 1.127-1. 966-4.348 1.00 0.00 H ATOM 12133 H8 GUA 19 7.483-2. 326-4.533 1.00 0.00 H ATOM 12134 H2'GUA 19 5.502 0.509-6. 924 1.00 0.00 H ATOM 12135 H02'GUA 19 6.955 1.440-8. 635 1.00 0.00 H ATOM 12136 H3'GUA 19 7.276 0.574-5. 302 1.00 0.00 H ATOM 12137 P ADE 20 7.437 3.216-6. 056 1.00 0.00 P ATOM 12138 01P ADE 20 8.103 4.396-6. 652 1.00 0. 00 0 ATOM 12139 02P ADE 20 7.476 3.009-4. 590 1.00 0.00 0 ATOM 12140 05'ADE 20 5.895 3.215-6. 521 1. 00 0.00 0 ATOM 12141 C5'ADE 20 5.527 3.652-7. 832 1.00 0.00 C ATOM 12142 C4'ADE 20 4.012 3.658-8. 015 1.00 0.00 C ATOM 12143 04'ADE 20 3.454 2.346-7. 849 1.00 0.00 0 ATOM 12144 C1'ADE 20 2.299 2. 419-6. 993 1.00 0.00 C ATOM 12145 N9 ADE 20 2.586 1.859-5. 656 1.00 0.00 N ATOM 12146 C4 ADE 20 1.663 1.506-4. 696 1.00 0.00 C ATOM 12147 N3 ADE 20 0.323 1.616-4. 796 1.00 0.00 N ATOM 12148 C2 ADE 20-0.280 1.186-3. 692 1.00 0.00 C ATOM 12149 N1 ADE 20 0.301 0. 698-2.595 1.00 0.00 N ATOM 12150 C6 ADE 20 1.639 0.598-2. 519 1. 00 0.00 C ATOM 12151 N6 ADE 20 2. 198 0. 094-1. 419 1. 00 0.00 N

ATOM 12152 C5 ADE 20 2.379 1.023-3. 626 1.00 0.00 C ATOM 12153 N7 ADE 20 3.752 1.064-3. 886 1.00 0.00 N ATOM 12154 C8 ADE 20 3.776 1.560-5. 076 1.00 0.00 C ATOM 12155 C2'ADE 20 1.953 3. 898-6. 903 1.00 0.00 C ATOM 12156 02'ADE 20 1.140 4.320-8. 005 1.00 0.00 0 ATOM 12157 C3'ADE 20 3.334 4.514-6. 955 1.00 0.00 C ATOM 12158 03'ADE 20 3. 226 5.854-7. 440 1.00 0.00 0 ATOM 12159 1H5'ADE 20 5.971 2.984-8. 570 1.00 0.00 H ATOM 12160 2H5'ADE 20 5.908 4.661-7. 991 1.00 0.00 H ATOM 12161 H4'ADE 20 3.761 4.035-9. 005 1.00 0.00 H ATOM 12162 H1'ADE 20 1.470 1.876-7. 448 1.00 0.00 H ATOM 12163 H2 ADE 20-1.368 1.239-3. 682 1.00 0.00 H ATOM 12164 1H6 ADE 20 3.202 0.007-1. 359 1.00 0.00 H ATOM 12165 2H6 ADE 20 1.617-0. 203-0.648 1. 00 0.00 H ATOM 12166 H8 ADE 20 4.717 1.738-5. 594 1. 00 0.00 H ATOM 12167 H2'ADE 20 1.470 4.118-5. 948 1.00 0.00 H ATOM 12168 H02'ADE 20 1.613 4.096-8. 810 1.00 0.00 H ATOM 12169 H3'ADE 20 3.843 4.454-5. 991 1.00 0.00 H ATOM 12170 P GUA 21 3.082 7.081-6. 408 1.00 0.00 P ATOM 12171 01P GUA 21 3.097 8. 343-7. 182 1.00 0.00 0 ATOM 12172 02P GUA 21 4.054 6.880-5. 309 1.00 0.00 0 ATOM 12173 05'GUA 21 1.601 6.867-5. 815 1.00 0.00 0 ATOM 12174 C5'GUA 21 0.451 7.261-6. 569 1.00 0.00 C ATOM 12175 C4'GUA 21-0. 834 7.089-5. 765 1.00 0.00 C ATOM 12176 04'GUA 21-1. 069 5.716-5. 428 1.00 0.00 0 ATOM 12177 C1'GUA 21-1.518 5.625-4. 063 1.00 0.00 C ATOM 12178 N9 GUA 21-0.508 4.960-3. 214 1.00 0.00 N ATOM 12179 C4 GUA 21-0.736 4.324-2. 014 1.00 0.00 C ATOM 12180 N3 GUA 21-1.927 4.230-1. 381 1.00 0.00 N ATOM 12181 C2 GUA 21-1.836 3.553-0. 233 1.00 0.00 C ATOM 12182 N2 GUA 21-2.918 3.381 0.526 1.00 0.00 N ATOM 12183 N1 GUA 21-0.660 3.009 0.244 1.00 0.00 N ATOM 12184 C6 GUA 21 0.573 3.091-0. 387 1.00 0.00 C ATOM 12185 06 GUA 21 1.561 2.563 0.118 1.00 0.00 0 ATOM 12186 C5 GUA 21 0.487 3.813-1. 607 1.00 0.00 C ATOM 12187 N7 GUA 21 1.484 4.123-2. 536 1.00 0. 00 N ATOM 12188 C8 GUA 21 0.821 4.784-3. 424 1.00 0.00 C ATOM 12189 C2'GUA 21-1.770 7.058-3. 608 1.00 0.00 C ATOM 12190 02'GUA 21-3.106 7.479-3. 910 1.00 0.00 0 ATOM 12191 C3'GUA 21-0.747 7.813-4. 432 1.00 0.00 C ATOM 12192 03'GUA 21-1.196 9.160-4. 612 1.00 0.00 0 ATOM 12193 1H5'GUA 21 0.390 6.653-7. 472 1.00 0.00 H ATOM 12194 2H5'GUA 21 0.555 8.309-6. 852 1.00 0.00 H ATOM 12195 H4'GUA 21-1. 679 7.472-6. 335 1.00 0.00 H ATOM 12196 H1'GUA 21-2. 451 5.062-4. 024 1.00 0.00 H ATOM 12197 1H2 GUA 21-3.806 3.762 0. 234 1.00 0.00 H ATOM 12198 2H2 GUA 21-2.849 2.873 1.397 1.00 0.00 H ATOM 12199 H1 GUA 21-0.675 2.509 1.120 1. 00 0.00 H ATOM 12200 H8 GUA 21 1.312 5.194-4. 305 1.00 0.00 H ATOM 12201 H2'GUA 21-1.555 7.161-2. 542 1.00 0.00 H ATOM 12202 H02'GUA 21-3.223 7.400-4. 859 1.00 0.00 H ATOM 12203 H3'GUA 21 0.252 7.755-3. 996 1.00 0.00 H ATOM 12204 P ADE 22-0.693 10.330-3. 626 1.00 0. 00 P ATOM 12205 O1P ADE 22 0.720 10.067-3. 274 1.00 0.00 0 ATOM 12206 02P ADE 22-1.074 11.631-4. 220 1.00 0.00 0 ATOM 12207 05'ADE 22-1.593 10.091-2. 312 1.00 0.00 0 ATOM 12208 C5'ADE 22-2.995 10.376-2. 332 1.00 0.00 C ATOM 12209 C4'ADE 22-3.719 9.726-1. 157 1.00 0.00 C ATOM 12210 04'ADE 22-3. 509 8. 310-1. 125 1.00 0.00 0 ATOM 12211 C1'ADE 22-3.339 7. 881 0. 239 1.00 0.00 C

ATOM 12212 N9 ADE 22-1.980 7.354 0.475 1.00 0.00 N ATOM 12213 C4 ADE 22-1.612 6.443 1.436 1.00 0.00 C ATOM 12214 N3 ADE 22-2.426 5.871 2.345 1. 00 0.00 N ATOM 12215 C2 ADE 22-1.760 5.035 3.132 1.00 0. 00 C ATOM 12216 N1 ADE 22-0.457 4.749 3.085 1.00 0.00 N ATOM 12217 C6 ADE 22 0.335 5.332 2.168 1.00 0.00 C ATOM 12218 N6 ADE 22 1.633 5.030 2.135 1.00 0.00 N ATOM 12219 C5 ADE 22-0.261 6. 236 1.284 1.00 0.00 C ATOM 12220 N7 ADE 22 0.244 7.008 0. 233 1.00 0.00 N ATOM 12221 C8 ADE 22-0.817 7.620-0. 173 1.00 0.00 C ATOM 12222 C2'ADE 22-3.607 9.108 1.104 1.00 0.00 C ATOM 12223 02'ADE 22-4.993 9.206 1.455 1.00 0.00 0 ATOM 12224 C3'ADE 22-3.185 10.225 0.174 1.00 0.00 C ATOM 12225 03'ADE 22-3.888 11.419 0.536 1.00 0. 00 O ATOM 12226 1H5'ADE 22-3.421 10.001-3. 262 1.00 0.00 H ATOM 12227 2H5'ADE 22-3.139 11.456-2. 285 1.00 0.00 H ATOM 12228 H4'ADE 22-4.787 9.931-1. 223 1.00 0.00 H ATOM 12229 Hl'ADE 22-4.073 7.109 0.470 1. 00 0.00 H ATOM 12230 H2 ADE 22-2.342 4.531 3.903 1.00 0.00 H ATOM 12231 1H6 ADE 22 2.235 5. 461 1.448 1.00 0.00 H ATOM 12232 2H6 ADE 22 2.015 4.368 2.797 1.00 0.00 H ATOM 12233 H8 ADE 22-0.779 8.329-0. 998 1.00 0.00 H ATOM 12234 H2'ADE 22-2.974 9.091 1.996 1.00 0.00 H ATOM 12235 H02'ADE 22-5.156 8.567 2.152 1.00 0.00 H ATOM 12236 H3'ADE 22-2.102 10.360 0.160 1.00 0.00 H ATOM 12237 P CYT 23-3.384 12.325 1.770 1.00 0.00 P ATOM 12238 O1P CYT 23-4.235 13.533 1.835 1.00 0. 00 0 ATOM 12239 02P CYT 23-1.913 12.464 1.673 1.00 0.00 0 ATOM 12240 05'CYT 23-3.717 11.402 3.048 1.00 0.00 0 ATOM 12241 C5'CYT 23-5.072 11.160 3.438 1.00 0.00 C ATOM 12242 C4'CYT 23-5.159 10.161 4.591 1.00 0.00 C ATOM 12243 04'CYT 23-4.534 8.919 4.267 1.00 0. 00 O ATOM 12244 C1'CYT 23-3.968 8.346 5.463 1.00 0.00 C ATOM 12245 N1 CYT 23-2.527 8.053 5.292 1.00 0.00 N ATOM 12246 C6 CYT 23-1.719 8.881 4.566 1. 00 0.00 C ATOM 12247 C2 CYT 23-2.032 6.903 5.894 1.00 0.00 C ATOM 12248 02 CYT 23-2.778 6.172 6.544 1.00 0.00 O ATOM 12249 N3 CYT 23-0.711 6.615 5.745 1.00 0.00 N ATOM 12250 C4 CYT 23 0.093 7.416 5.037 1.00 0.00 C ATOM 12251 N4 CYT 23 1.382 7.101 4.912 1.00 0.00 N ATOM 12252 C5 CYT 23-0.410 8.602 4.415 1.00 0.00 C ATOM 12253 C2'CYT 23-4.196 9.365 6. 585 1. 00 0.00 C ATOM 12254 02'CYT 23-5.346 9.029 7.371 1.00 0.00 0 ATOM 12255 C3'CYT 23-4.408 10.655 5.810 1.00 0.00 C ATOM 12256 03'CYT 23-5.276 11.512 6.560 1.00 0.00 0 ATOM 12257 1H5'CYT 23-5.623 10.765 2.585 1.00 0.00 H ATOM 12258 2H5'CYT 23-5.526 12.101 3.749 1.00 0.00 H ATOM 12259 H4'CYT 23-6.202 9.984 4.847 1. 00 0.00 H ATOM 12260 H1'CYT 23-4.497 7.423 5.703 1.00 0.00 H ATOM 12261 H6 CYT 23-2.137 9.776 4.105 1.00 0.00 H ATOM 12262 1H4 CYT 23 1.998 7.698 4.379 1.00 0.00 H ATOM 12263 2H4 CYT 23 1.742 6.266 5.349 1.00 0.00 H ATOM 12264. H5 CYT 23 0.243 9.257 3.840 1.00 0.00 H ATOM 12265 H2'CYT 23-3.303 9.442 7.212 1.00 0.00 H ATOM 12266 H02'CYT 23-6.101 9.011 6.779 1.00 0.00 H ATOM 12267 H3'CYT 23-3.464 11.135 5.547 1.00 0.00 H ATOM 12268 P GUA 24-4.686 12.513 7.676 1.00 0. 00 P ATOM 12269 01P GUA 24-5.718 13.530 7.976 1.00 0.00 0 ATOM 12270 02P GUA 24-3.333 12.938 7.251 1. 00 0. 00 0 ATOM 12271 05'GUA 24-4.531 11.556 8.961 1.00 0. 00 0

ATOM 12272 C5'GUA 24-5. 686 11. 008 9. 604 1. 00 0. 00 C ATOM 12273 C4'GUA 24-5. 344 10. 433 10. 975 1. 00 0. 00 C ATOM 12274 04'GUA 24-4. 347 9. 401 10. 879 1. 00 0. 00 0 ATOM 12275 Cl'GUA 24-3. 310 9. 650 11. 843 1. 00 0. 00 C ATOM 12276 N9 GUA 24-2. 099 10. 193 11. 204 1. 00 0. 00 N ATOM 12277 C4 GUA 24-0. 891 10. 410 11. 816 1. 00 0. 00 C ATOM 12278 N3 GUA 24-0. 609 10. 155 13. 112 1. 00 0. 00 N ATOM 12279 C2 GUA 24 0. 648 10. 467 13. 424 1. 00 0. 00 C ATOM 12280 N2 GUA 24 1. 094 10. 268 14. 664 1. 00 0. 00 N ATOM 12281 N1 GUA 24 1. 551 10. 990 12. 524 1. 00 0. 00 N ATOM 12282 C6 GUA 24 1. 287 11. 262 11. 188 1. 00 0. 00 C ATOM 12283 06 GUA 24 2. 165 11. 733 10. 468 1. 00 0. 00 0 ATOM 12284 C5 GUA 24-0. 050 10. 932 10. 847 1. 00 0. 00 C ATOM 12285 N7 GUA 24-0. 720 11. 045 9. 624 1. 00 0. 00 N ATOM 12286 C8 GUA 24-1. 892 10. 596 9. 925 1. 00 0. 00 C ATOM 12287 C2'GUA 24-3. 902 10. 650 12. 821 1. 00 0. 00 C ATOM 12288 02'GUA 24-4. 707 10. 002 13. 814 1. 00 0. 00 O ATOM 12289 C3'GUA 24-4. 736 11. 494 11. 883 1. 00 0. 00 C ATOM 12290 03'GUA 24-5. 783 12. 122 12. 632 1. 00 0. 00 0 ATOM 12291 1H5'GUA 24-6. 100 10. 217 8. 979 1. 00 0. 00 H ATOM 12292 2H5'GUA 24-6. 433 11. 794 9. 724 1. 00 0. 00 H ATOM 12293 H4'GUA 24-6. 242 10. 025 11. 437 1. 00 0. 00 H ATOM 12294 H1'GUA 24-3. 061 8. 730 12. 370 1. 00 0. 00 H ATOM 12295 1H2 GUA 24 0. 480 9. 881 15. 366 1. 00 0. 00 H ATOM 12296 2H2 GUA 24 2. 047 10. 504 14. 901 1. 00 0. 00 H ATOM 12297 H1 GUA 24 2. 483 11. 197 12. 839 1. 00 0. 00 H ATOM 12298 H8 GUA 24-2. 686 10. 542 9. 180 1. 00 0. 00 H ATOM 12299 H2'GUA 24-3. 111 11. 247 13. 279 1. 00 0. 00 H ATOM 12300 H02'GUA 24-4. 109 9. 583 14. 437 1. 00 0. 00 H ATOM 12301 H3'GUA 24-4. 126 12. 210 11. 329 1. 00 0. 00 H ATOM 12302 P ADE 25-5. 553 13. 567 13. 309 1. 00 0. 00 P ATOM 12303 01P ADE 25-4. 810 14. 415 12. 351 1. 00 0. 00 0 ATOM 12304 02P ADE 25-6. 847 14. 032 13. 856 1. 00 0. 00 0 ATOM 12305 05'ADE 25-4. 575 13. 228 14. 545 1. 00 0. 00 0 ATOM 12306 C5'ADE 25-5. 007 12. 352 15. 591 1. 00 0. 00 C ATOM 12307 C4'ADE 25-3. 831 11. 811 16. 401 1. 00 0. 00 C ATOM 12308 04'ADE 25-2. 829 11. 230 15. 553 1. 00 0. 00 0 ATOM 12309 Cl'ADE 25-1. 527 11. 679 15. 971 1. 00 0. 00 C ATOM 12310 N9 ADE 25-0. 959 12. 648 15. 009 1. 00 0. 00 N ATOM 12311 C4 ADE 25 0. 325 13. 149 15. 003 1. 00 0. 00 C ATOM 12312 N3 ADE 25 1. 305 12. 850 15. 879 1. 00 0. 00 N ATOM 12313 C2 ADE 25 2. 427 13. 502 15. 591 1. 00 0. 00 C ATOM 12314 N1 ADE 25 2. 629 14. 356 14. 585 1. 00 0. 00 N ATOM 12315 C6 ADE 25 1. 635 14. 638 13. 724 1. 00 0. 00 C ATOM 12316 N6 ADE 25 1. 857 15. 493 12. 727 1. 00 0. 00 N ATOM 12317 C5 ADE 25 0. 405 14. 006 13. 930 1. 00 0. 00 C ATOM 12318 N7 ADE 25-0. 814 14. 063 13. 248 1. 00 0. 00 N ATOM 12319 C8 ADE 25-1. 538 13. 250 13. 940 1. 00 0. 00 C ATOM 12320 C2'ADE 25-1. 735 12. 316 17. 337 1. 00 0. 00 c ATOM 12321 02'ADE 25-1. 713 11. 336 18. 382 1. 00 0. 00 0 ATOM 12322 C3'ADE 25-3. 113 12. 917 17. 162 1. 00 0. 00 c ATOM 12323 03'ADE 25-3. 727 13. 057 18. 448 1. 00 0. 00 0 ATOM 12324 1H5'ADE 25-5. 547 11. 514 15. 150 1. 00 0. 00 H ATOM 12325 2H5'ADE 25-5. 677 12. 896 16. 257 1. 00 0.00 H ATOM 12326 H4'ADE 25-4. 186 11. 058 17. 103 1. 00 0. 00 H ATOM 12327 H1' ADE 25-0. 860 10. 822 16. 066 1. 00 0. 00 H ATOM 12328 H2 ADE 25 3. 278 13. 316 16. 246 1. 00 0. 00 H ATOM 12329 1H6 ADE 25 1. 117 15. 711 12. 075 1. 00 0. 00 H ATOM 12330 2H6 ADE 25 2. 766 15. 923 12. 623 1. 00 0. 00 H ATOM 12331 H8 ADE 25-2. 576 13. 053 13. 675 1. 00 0. 00 H

ATOM 12332 H2'ADE 25-0. 993 13.098 17.509 1.00 0.00 H ATOM 12333 H02'ADE 25-2.356 10.661 18.154 1.00 0.00 H ATOM 12334 H3'ADE 25-3.079 13.855 16.605 1.00 0.00 H ATOM 12335 P CYT 26-3.415 14.339 19.373 1.00 0.00 P ATOM 12336 01P CYT 26-3.303 15.528 18.499 1.00 0. 00 0 ATOM 12337 02P CYT 26-4.374 14.340 20.501 1.00 0.00 0 ATOM 12338 05'CYT 26-1.953 14.002 19.953 1.00 0.00 0 ATOM 12339 C5'CYT 26-1. 748 12.864 20.795 1.00 0.00 C ATOM 12340 C4'CYT 26-0.263 12.599 21.026 1.00 0.00 C ATOM 12341 04'CYT 26 0.433 12.368 19.790 1.00 0.00 O ATOM 12342 Cl'CYT 26 1.664 13.117 19.788 1.00 0.00 C ATOM 12343 N1 CYT 26 1.593 14.279 18.876 1.00 0.00 N ATOM 12344 C6 CYT 26 0.401 14.881 18. 602 1.00 0.00 C ATOM 12345 C2 CYT 26 2.785 14.756 18.342 1.00 0.00 C ATOM 12346 02 CYT 26 3.848 14.195 18.601 1.00 0.00 0 ATOM 12347 N3 CYT 26 2.736 15.851 17.535 1.00 0. 00 N ATOM 12348 C4 CYT 26 1.571 16.452 17.264 1.00 0.00 C ATOM 12349 N4 CYT 26 1.557 17.520 16.467 1.00 0.00 N ATOM 12350 C5 CYT 26 0.346 15.962 17.813 1.00 0.00 C ATOM 12351 C2'CYT 26 1.858 13.584 21.220 1.00 0.00 C ATOM 12352 02'CYT 26 2.501 12. 585 22.022 1.00 0.00 0 ATOM 12353 C3'CYT 26 0.422 13.808 21.642 1.00 0.00 C ATOM 12354 03'CYT 26 0.337 13.711 23.068 1.00 0.00 0 ATOM 12355 1H5'CYT 26-2.197 11.988 20.327 1.00 0.00 H ATOM 12356 2H5'CYT 26-2.231 13.041 21.757 1.00 0.00 H ATOM 12357 H4'CYT 26-0. 140 11.735 21.677 1.00 0.00 H ATOM 12358 Hl'CYT 26 2.490 12.468 19.496 1.00 0.00 H ATOM 12359 H6 CYT 26-0.521 14.473 19.020 1.00 0.00 H ATOM 12360 1H4 CYT 26 0.683 17.980 16.254 1.00 0.00 H ATOM 12361 2H4 CYT 26 2. 418 17.869 16.075 1.00 0.00 H ATOM 12362 H5 CYT 26-0. 598 16.461 17.619 1.00 0.00 H ATOM 12363 H2'CYT 26 2.413 14.525 21.237 1.00 0.00 H ATOM 12364 H02'CYT 26 1.971 11.787 21.962 1.00 0. 00 H ATOM 12365 H3'CYT 26 0.024 14.750 21.254 1.00 0.00 H ATOM 12366 P CYT 27 0.334 15.038 23.984 1.00 0.00 P ATOM 12367 01P CYT 27-0. 717 15.949 23.476 1.00 0.00 O ATOM 12368 02P CYT 27 0.323 14.620 25.403 1.00 0.00 0 ATOM 12369 05'CYT 27 1.769 15.696 23.661 1.00 0.00 0 ATOM 12370 C5'CYT 27 2.977 14. 983 23.944 1.00 0.00 C ATOM 12371 C4'CYT 27 4.148 15.511 23.117 1.00 0.00 C ATOM 12372 04'CYT 27 3.835 15.545 21.724 1.00 0.00 0 ATOM 12373 C1'CYT 27 4.516 16.658 21.111 1.00 0.00 C ATOM 12374 N1 CYT 27 3.576 17.569 20.419 1.00 0.00 N ATOM 12375 C6 CYT 27 2.225 17.489 20.619 1.00 0.00 C ATOM 12376 C2 CYT 27 4.124 18.514 19.562 1.00 0.00 C ATOM 12377 02 CYT 27 5.342 18.575 19.406 1.00 0.00 O ATOM 12378 N3 CYT 27 3.285 19.365 18.916 1.00 0.00 N ATOM 12379 C4 CYT 27 1.962 19.299 19.099 1.00 0.00 C ATOM 12380 N4 CYT 27 1.173 20.147 18.442 1.00 0.00 N ATOM 12381 C5 CYT 27 1.387 18.332 19.982 1.00 0.00 C ATOM 12382 C2'CYT 27 5.249 17.390 22.236 1.00 0.00 C ATOM 12383 02'CYT 27 6.623 16.993 22.308 1. 00 0.00 O ATOM 12384 C3'CYT 27 4.472 16.950 23.463 1.00 0.00 C ATOM 12385 03'CYT 27 5.351 16.967 24.595 1.00 0.00 O ATOM 12386 1H5'CYT 27 2.830 13.928 23.715 1.00 0.00 H ATOM 12387 2H5'CYT 27 3. 213 15.088 25.003 1.00 0. 00 H ATOM 12388 H4'CYT 27 5.025 14.886 23.276 1.00 0.00 H ATOM 12389 H1'CYT 27 5.246 16.281 20.394 1.00 0.00 H ATOM 12390 H6 CYT 27 1.823 16.739 21.301 1.00 0.00 H ATOM 12391 1H4 CYT 27 0.172 20.106 18.567 1.00 0.00 H

ATOM 12392 2H4 CYT 27 1.579 20.834 17.821 1.00 0.00 H ATOM 12393 H5 CYT 27 0.308 18.284 20.137 1.00 0.00 H ATOM 12394 H2'CYT 27 5.159 18.470 22. 100 1.00 0.00 H ATOM 12395 H02'CYT 27 7.056 17.322 21.517 1.00 0.00 H ATOM 12396 H3'CYT 27 3.574 17.551 23.616 1.00 0.00 H ATOM 12397 P GUA 28 5.811 18.361 25.261 1.00 0. 00 P ATOM 12398 01P GUA 28 4.683 19.315 25.165 1.00 0.00 0 ATOM 12399 02P GUA 28 6.414 18.066 26.580 1.00 0.00 0 ATOM 12400 05'GUA 28 6.980 18.864 24.269 1.00 0.00 0 ATOM 12401 C5'GUA 28 8.338 18.451 24.465 1.00 0.00 C ATOM 12402 C4'GUA 28 9.324 19. 477 23.907 1.00 0.00 C ATOM 12403 04'GUA 28 9.211 19.599 22.480 1.00 0.00 0 ATOM 12404 C1'GUA 28 9.082 20.985 22.120 1.00 0.00 C ATOM 12405 N9 GUA 28 7.689 21.302 21.747 1.00 0.00 N ATOM 12406 C4 GUA 28 7.257 22.364 20.982 1.00 0.00 C ATOM 12407 N3 GUA 28 8.035 23.340 20.460 1.00 0.00 N ATOM 12408 C2 GUA 28 7.325 24.233 19.761 1.00 0.00 C ATOM 12409 N2 GUA 28 7.936 25.269 19.188 1.00 0.00 N ATOM 12410 N1 GUA 28 5.956 24.160 19.593 1.00 0.00 N ATOM 12411 C6 GUA 28 5.139 23.170 20.118 1.00 0.00 C ATOM 12412 06 GUA 28 3.931 23.188 19.901 1.00 0.00 O ATOM 12413 C5 GUA 28 5.882 22.219 20.863 1.00 0.00 C ATOM 12414 N7 GUA 28 5.446 21. 082 21.548 1.00 0.00 N ATOM 12415 C8 GUA 28 6.551 20. 622 22.024 1.00 0.00 C ATOM 12416 C2'GUA 28 9.525 21.769 23.346 1.00 0.00 C ATOM 12417 02'GUA 28 10.948 21.934 23.381 1.00 0.00 0 ATOM 12418 C3'GUA 28 9.039 20.866 24.463 1.00 0.00 C ATOM 12419 03'GUA 28 9.864 21.071 25.614 1.00 0.00 O ATOM 12420 lH5'GUA 28 8.496 17.496 23. 964. 1.00 0.00 H ATOM 12421 2H5'GUA 28 8.521 18.328 25.532 1.00 0.00 H ATOM 12422 H4'GUA 28 10.341 19.183 24.164 1.00 0.00 H ATOM 12423 Hl'GUA 28 9.745 21.208 21.283 1.00 0.00 H ATOM 12424 1H2 GUA 28 8.936 25.380 19.281 1.00 0.00 H ATOM 12425 2H2 GUA 28 7.400 25.944 18.660 1.00 0.00 H ATOM 12426 HI GUA 28 5.493 24.872 19.046 1.00 0.00 H ATOM 12427 H8 GUA 28 6.571 19. 720 22.633 1.00 0.00 H ATOM 12428 H2'GUA 28 9.015 22.734 23.384 1.00 0.00 H ATOM 12429 H02'GUA 28 11.338 21.058 23.353 1.00 0. 00 H ATOM 12430 H3'GUA 28 7.979 21.014 24.674 1.00 0.00 H ATOM 12431 P CYT 29 9.334 21.951 26.852 1.00 0.00 P ATOM 12432 01P CYT 29 7.923 21.584 27.113 1.00 0.00 0 ATOM 12433 02P CYT 29 10.332 21.866 27.943 1.00 0.00 0 ATOM 12434 05'CYT 29 9.361 23.446 26.255 1.00 0.00 O ATOM 12435 C5'CYT 29 10.552 24.238 26.309 1.00 0.00 C ATOM 12436 C4'CYT 29 10.280 25.682 25.893 1.00 0.00 C ATOM 12437 04'CYT 29 9.880 25.767 24.518 1.00 0.00 0 ATOM 12438 C1'CYT 29 8.712 26.599 24.399 1.00 0.00 C ATOM 12439 Nl CYT 29 7.511 25. 789 24.085 1.00 0.00 N ATOM 12440 C6 CYT 29 7.446 24.469 24.429 1.00 0. 00 C ATOM 12441 C2 CYT 29 6.470 26. 411 23.406 1.00 0.00 C ATOM 12442 02 CYT 29 6. 544 27.604 23.114 1.00 0.00 O ATOM 12443 N3 CYT 29 5.376 25.668 23.084 1.00 0.00 N ATOM 12444 C4 CYT 29 5.302 24.371 23.413 1.00 0.00 C ATOM 12445 N4 CYT 29 4.221 23. 671 23.078 1.00 0.00 N ATOM 12446 C5 CYT 29 6.368 23.729 24.114 1.00 0.00 C ATOM 12447 C2'CYT 29 8.574 27.312 25.739 1.00 0.00 C ATOM 12448 02'CYT 29 9.342 28.520 25.773 1.00 0.00 0 ATOM 12449 C3'CYT 29 9.126 26.271 26.691 1.00 0.00 C ATOM 12450 03'CYT 29 9.665 26.932 27.841 1.00 0.00 O ATOM 12451 lH5'CYT 29 11.299 23.809 25.642 1.00 0. 00 H

ATOM 12452 2H5'CYT 29 10.938 24.230 27.329 1.00 0.00 H ATOM 12453 H4'CYT 29 11.176 26.283 26.047 1.00 0.00 H ATOM 12454 H1'CYT 29 8.871 27. 335 23.611 1.00 0.00 H ATOM 12455 H6 CYT 29 8.276 24.010 24.965 1.00 0.00 H ATOM 12456 1H4 CYT 29 4.157 22.692 23.320 1.00 0.00 H ATOM 12457 2H4 CYT 29 3.465 24.117 22.579 1.00 0.00 H ATOM 12458 H5 CYT 29 6.310 22.675 24.386 1.00 0.00 H ATOM 12459 H2'CYT 29 7.521 27.509 25.956 1.00 0.00 H ATOM 12460 H02'CYT 29 9.349 28.828 26.683 1.00 0.00 H ATOM 12461 H3'CYT 29 8.380 25.518 26.951 1.00 0.00 H ATOM 12462 P CYT 30 9.163 26.546 29. 322 1.00 0.00 P ATOM 12463 O1P CYT 30 10.224 26.922 30.283 1.00 0.00 0 ATOM 12464 02P CYT 30 8.652 25.157 29.293 1.00 0.00 0 ATOM 12465 05'CYT 30 7.913 27.538 29.534 1.00 0.00 O ATOM 12466 C5'CYT 30 8.113 28.953 29.618 1.00 0.00 C ATOM 12467 C4'CYT 30 6.992 29.720 28.922 1.00 0.00 C ATOM 12468 04'CYT 30 6.850 29.321 27.555 1.00 0.00 0 ATOM 12469 C1'CYT 30 5.453 29.274 27.215 1.00 0.00 C ATOM 12470 Nl CYT 30 5.020 27.894 26.895 1.00 0.00 N ATOM 12471 C6 CYT 30 5.602 26.813 27.495 1.00 0.00 C ATOM 12472 C2 CYT 30 3.997 27.742 25.968 1.00 0.00 C ATOM 12473 02 CYT 30 3.487 28.729 25.440 1.00 0.00 O ATOM 12474 N3 CYT 30 3.581 26. 483 25.665 1.00 0.00 N ATOM 12475 C4 CYT 30 4.141 25.414 26.246 1.00 0.00 C ATOM 12476 N4 CYT 30 3.705 24.196 25.928 1.00 0.00 N ATOM 12477 C5 CYT 30 5.195 25.563 27.201 1.00 0.00 C ATOM 12478 C2'CYT 30 4.709 29.818 28.432 1.00 0.00 C ATOM 12479 02'CYT 30 4.542 31.239 28.351 1.00 0.00 O ATOM 12480 C3'CYT 30 5.644 29.431 29.559 1.00 0.00 C ATOM 12481 03'CYT 30 5.425 30.222 30.733 1.00 0.00 0 ATOM 12482 1H5'CYT 30 9.063 29. 208 29.146 1.00 0.00 H ATOM 12483 2H5'CYT 30 8.147 29.246 30. 667 1.00 0.00 H ATOM 12484 H4'CYT 30 7.196 30.789 28.966 1.00 0.00 H ATOM 12485 Hl'CYT 30 5.268 29.921 26.358 1.00 0.00 H ATOM 12486 H6 CYT 30 6.404 26.962 28.218 1.00 0.00 H ATOM 12487 1H4 CYT 30 4.118 23.382 26.361 1.00 0.00 H ATOM 12488 2H4 CYT 30 2.959 24.086 25.255 1.00 0.00 H ATOM 12489 H5 CYT 30 5.654 24.695 27.674 1.00 0.00 H ATOM 12490 H2'CYT 30 3.745 29. 314 28. 545 1.00 0.00 H ATOM 12491 H02'CYT 30 5.412 31.621 28.220 1.00 0.00 H ATOM 12492 H3'CYT 30 5.548 28.363 29.775 1.00 0.00 H ATOM 12493 H03'CYT 30 4.547 30.010 31.061 1.00 0.00 H ATOM 12494 05'GUA 1 1.121 6.379 3. 320 1.00 0.00 0 ATOM 12495 C5'GUA 1 2.341 6.417 4.065 1.00 0.00 C ATOM 12496 C4'GUA 1 2.572 7.788 4.698 1.00 0.00 C ATOM 12497 04'GUA 1 2.648 8.822 3.702 1.00 0.00 0 ATOM 12498 C1'GUA 1 1.804 9.922 4.086 1.00 0.00 C ATOM 12499 N9 GUA 1 0. 571 9.956 3.272 1.00 0.00 N ATOM 12500 C4 GUA 1-0.110 11.078 2.851 1.00 0.00 C ATOM 12501 N3 GUA 1 0.217 12.359 3.135 1.00 0.00 N ATOM 12502 C2 GUA 1-0. 633 13.232 2.584 1.00 0.00 C ATOM 12503 N2 GUA 1-0. 461 14.540 2.774 1.00 0.00 N ATOM 12504 N1 GUA 1-1. 718 12.862 1.813 1.00 0.00 N ATOM 12505 C6 GUA 1-2. 074 11.556 1.508 1.00 0.00 C ATOM 12506 06 GUA 1-3.060 11.332 0.809 1.00 0.00 0 ATOM 12507 C5 GUA 1-1. 177 10.622 2.091 1.00 0.00 C ATOM 12508 N7 GUA 1-1. 178 9.226 2.031 1.00 0.00 N ATOM 12509 C8 GUA 1-0. 140 8.932 2.737 1.00 0.00 C ATOM 12510 C2'GUA 1 1.490 9.696 5.556 1.00 0.00 C ATOM 12511 02'GUA 1 2.535 10.197 6.400 1. 00 0. 00 O

ATOM 12512 C3'GUA 1 1.410 8.184 5.599 1.00 0.00 C ATOM 12513 03'GUA 1 1.689 7.743 6.932 1.00 0.00 0 ATOM 12514 H5'GUA 1 0.399 6.429 3.951 1.00 0.00 H ATOM 12515 1H5'GUA 1 3.173 6.188 3.399 1.00 0.00 H ATOM 12516 2H5'GUA 1 2.299 5.665 4.853 1.00 0.00 H ATOM 12517 H4'GUA 1 3.496 7.775 5.275 1.00 0.00 H ATOM 12518 Hl'GUA 1 2.349 10.860 3.967 1.00 0.00 H ATOM 12519 1H2 GUA 1 0.311 14.871 3.335 1.00 0.00 H ATOM 12520 2H2 GUA 1-1.099 15.200 2.353 1.00 0.00 H ATOM 12521 Hl GUA 1-2.307 13.583 1.423 1. 00 0.00 H ATOM 12522 H8 GUA 1 0.153 7.896 2.904 1.00 0.00 H ATOM 12523 H2'GUA 1 0.527 10.140 5.812 1.00 0.00 H ATOM 12524 H02'GUA 1 2.409 9.810 7.269 1.00 0.00 H ATOM 12525 H3'GUA 1 0.454 7.816 5.224 1.00 0.00 H ATOM 12526 P GUA 2 0. 488 7. 479 7.972 1.00 0.00 P ATOM 12527 01P GUA 2-0.605 6.785 7.254 1.00 0.00 0 ATOM 12528 02P GUA 2 1.060 6.882 9.199 1.00 0.00 0 ATOM 12529 05'GUA 2-0.007 8.971 8.319 1.00 0.00 0 ATOM 12530 C5'GUA 2 0.756 9.806 9. 194 1.00 0.00 C ATOM 12531 C4'GUA 2 0.255 11.246 9.175 1.00 0.00 C ATOM 12532 04'GUA 2 0.308 11.808 7.857 1.00 0.00 O ATOM 12533 Cl'GUA 2-0.888 12.574 7.614 1.00 0.00 C ATOM 12534 N9 GUA 2-1.733 11.936 6.584 1.00 0.00 N ATOM 12535 C4 GUA 2-2.615 12.572 5.739 1.00 0.00 C ATOM 12536 N3 GUA 2-2.867 13.901 5.708 1.00 0.00 N ATOM 12537 C2 GUA 2-3.773 14.221 4.779 1.00 0.00 C ATOM 12538 N2 GUA 2-4.143 15. 492 4.619 1.00 0. 00 N ATOM 12539 N1 GUA 2-4.378 13.299 3.949 1.00 0.00 N ATOM 12540 C6 GUA 2-4.137 11.932 3.963 1.00 0.00 C ATOM 12541 06 GUA 2-4.732 11.193 3.184 1.00 0.00 O ATOM 12542 C5 GUA 2-3.176 11.582 4.947 1.00 0.00 C ATOM 12543 N7 GUA 2-2.658 10.328 5.284 1.00 0.00 N ATOM 12544 C8 GUA 2-1.838 10.629 6.233 1.00 0.00 C ATOM 12545 C2'GUA 2-1.615 12.645 8.952 1.00 0.00 C ATOM 12546 02'GUA 2-1.168 13.759 9.735 1.00 0.00 0 ATOM 12547 C3'GUA 2-1. 207 11.326 9.574 1.00 0.00 C ATOM 12548 03'GUA 2-1.291 11.438 10. 998 1.00 0.00 0 ATOM 12549 1H5'GUA 2 1.801 9.789 8.884 1.00 0.00 H ATOM 12550 2H5'GUA 2 0.681 9.417 10.210 1.00 0.00 H ATOM 12551 H4'GUA 2 0.855 11.854 9.851 1.00 0.00 H ATOM 12552 H1'GUA 2-0.617 13.580 7.293 1.00 0.00 H ATOM 12553 1H2 GUA 2-3.738 16.212 5.200 1.00 0.00 H ATOM 12554 2H2 GUA 2-4.827 15.735 3.917 1.00 0.00 H ATOM 12555 Hl GUA 2-5.051 13.623 3.269 1.00 0.00 H ATOM 12556 H8 GUA 2-1.251 9.860 6.734 1.00 0.00 H ATOM 12557 H2'GUA 2-2.696 12.679 8.797 1.00 0.00 H ATOM 12558 H02'GUA 2-1.442 13.599 10.641 1.00 0.00 H ATOM 12559 H3'GUA 2-1.789 10.491 9.180 1.00 0.00 H ATOM 12560 P CYT 3-2.575 10.870 11.787 1.00 0.00 P ATOM 12561 01P CYT 3-2.343 11.046 13.238 1.00 0.00 O ATOM 12562 02P CYT 3-2.896 9.529 11.248 1.00 0. 00 O ATOM 12563 05'CYT 3-3.739 11. 887 11.334 1.00 0.00 O ATOM 12564 C5'CYT 3-3.782 13.218 11.855 1.00 0. 00 C ATOM 12565 C4'CYT 3-4.682 14.125 11.019 1.00 0.00 C ATOM 12566 04'CYT 3-4.254 14.194 9.650 1.00 0.00 0 ATOM 12567 Cl'CYT 3-5.414 14.168 8.791 1.00 0.00 C ATOM 12568 N1 CYT 3-5.503 12.899 8.035 1.00 0.00 N ATOM 12569 C6 CYT 3-5.001 11.739 8.550 1.00 0.00 C ATOM 12570 C2 CYT 3-6.135 12.928 6.798 1.00 0.00 C ATOM 12571 02 CYT 3-6.585 13.984 6.356 1.00 0.00 O

ATOM 12572 N3 CYT 3-6.245 11.764 6.104 1.00 0.00 N ATOM 12573 C4 CYT 3-5.758 10.619 6.598 1.00 0.00 C ATOM 12574 N4 CYT 3-5.878 9.498 5.887 1.00 0.00 N ATOM 12575 C5 CYT 3-5.107 10.585 7.871 1.00 0.00 C ATOM 12576 C2'CYT 3-6.610 14.319 9.720 1.00 0.00 C ATOM 12577 02'CYT 3-6.893 15.697 9.997 1.00 0.00 0 ATOM 12578 C3'CYT 3-6. 101 13.592 10.944 1.00 0.00 C ATOM 12579 03'CYT 3-6.832 14.040 12.090 1.00 0.00 0 ATOM 12580 1H5'CYT 3-2.773 13.630 11.864 1.00 0.00 H ATOM 12581 2H5'CYT 3-4.162 13.186 12. 876 1.00 0.00 H ATOM 12582 H4'CYT 3-4.688 15.128 11.444 1.00 0.00 H ATOM 12583 H1'CYT 3-5.379 15.008 8.099 1.00 0. 00 H ATOM 12584 H6 CYT 3-4.509 11.749 9. 522 1.00 0.00 H ATOM 12585 1H4 CYT 3-5.511 8.629 6.248 1.00 0.00 H ATOM 12586 2H4 CYT 3-6.341 9. 517 4.989 1.00 0.00 H ATOM 12587 H5 CYT 3-4.718 9.655 8.283 1.00 0.00 H ATOM 12588 H2'CYT 3-7.480 13.810 9.304 1.00 0.00 H ATOM 12589 H02'CYT 3-6.080 16.096 10.315 1.00 0.00 H ATOM 12590 H3'CYT 3-6.128 12. 506 10.817 1.00 0.00 H ATOM 12591 P GUA 4-8.248 13.369 12.468 1.00 0.00 P ATOM 12592 01P GUA 4-8.149 11. 911 12.232 1.00 0.00 0 ATOM 12593 02P GUA 4-8.660 13.876 13.796 1.00 0.00 0 ATOM 12594 05'GUA 4-9.240 13.990 11.361 1.00 0.00 0 ATOM 12595 C5'GUA 4-9.550 15.387 11.363 1.00 0.00 C ATOM 12596 C4'GUA 4-10. 317 15.797 10.109 1.00 0.00 C ATOM 12597 04'GUA 4-9.592 15.463 8.917 1.00 0.00 0 ATOM 12598 C1'GUA 4-10.494 14.894 7.948 1.00 0.00 C ATOM 12599 N9 GUA 4-10.234 13.454 7.751 1.00 0.00 N ATOM 12600 C4 GUA 4-10.639 12.688 6.683 1.00 0.00 C ATOM 12601 N3 GUA 4-11.364 13.121 5.628 1.00 0.00 N ATOM 12602 C2 GUA 4-11.608 12.146 4.749 1.00 0.00 C ATOM 12603 N2 GUA 4-12.321 12.403 3.653 1.00 0.00 N ATOM 12604 N1 GUA 4-11.165 10.847 4.904 1.00 0. 00 N ATOM 12605 C6 GUA 4-10.418 10.379 5.976 1.00 0.00 C ATOM 12606 06 GUA 4-10.062 9.204 6. 014 1.00 0.00 0 ATOM 12607 C5 GUA 4-10.157 11.409 6.917 1.00 0.00 C ATOM 12608 N7 GUA 4-9.454 11.362 8.124 1.00 0.00 N ATOM 12609 C8 GUA 4-9.552 12. 581 8.533 1. 00 0.00 C ATOM 12610 C2'GUA 4-11.894 15.125 8.500 1.00 0.00 C ATOM 12611 02'GUA 4-12. 404 16.407 8.114 1.00 0.00 0 ATOM 12612 C3'GUA 4-11.635 15.047 9.990 1.00 0.00 C ATOM 12613 03'GUA 4-12. 651 15.789 10.675 1.00 0.00 0 ATOM 12614 1H5'GUA 4-8.623 15.957 11.414 1. 00 0.00 H ATOM 12615 2H5'GUA 4-10.156 15.615 12.241 1.00 0.00 H ATOM 12616 H4'GUA 4-10.505 16.869 10.127 1.00 0.00 H ATOM 12617 H1'GUA 4-10.385 15.419 6.998 1.00 0.00 H ATOM 12618 1H2 GUA 4-12.675 13.334 3.488 1.00 0.00 H ATOM 12619 2H2 GUA 4-12.515 11.666 2.993 1.00 0.00 H ATOM 12620 Hl GUA 4-11.397 10.165 4.198 1.00 0.00 H ATOM 12621 H8 GUA 4-9.120 12.892 9.482 1.00 0.00 H ATOM 12622 H2'GUA 4-12.563 14.321 8.184 1.00 0.00 H ATOM 12623 H02'GUA 4-12.713 16.330 7.208 1.00 0.00 H ATOM 12624 H3'GUA 4-11.556 14.016 10.339 1.00 0.00 H ATOM 12625 P CYT 5-14.113 15.151 10.913 1.00 0.00 P ATOM 12626 01P CYT 5-14.892 16.083 11.759 1.00 0.00 0 ATOM 12627 02P CYT 5-13.942 13.742 11.333 1.00 0.00 0 ATOM 12628 05'CYT 5-14.748 15.161 9. 433 1.00 0.00 0 ATOM 12629 C5'CYT 5-15.106 16.395 8.803 1.00 0.00 C ATOM 12630 C4'CYT 5-15.661 16.170 7.400 1.00 0.00 C ATOM 12631 04'CYT 5-14.713 15. 509 6. 554 1.00 0.00 O

ATOM 12632 C1'CYT 5-15.399 14.562 5.710 1.00 0.00 C ATOM 12633 N1 CYT 5-14.963 13.177 5.986 1.00 0.00 N ATOM 12634 C6 CYT 5-14.515 12.816 7. 222 1.00 0.00 C ATOM 12635 C2 CYT 5-15.031 12.261 4.943 1.00 0.00 C ATOM 12636 02 CYT 5-15.440 12.610 3.837 1.00 0.00 0 ATOM 12637 N3 CYT 5-14.638 10. 982 5.183 1.00 0.00 N ATOM 12638 C4 CYT 5-14.195 10.613 6.391 1.00 0.00 C ATOM 12639 N4 CYT 5-13.818 9.352 6.590 1.00 0.00 N ATOM 12640 C5 CYT 5-14.123 11.553 7.467 1.00 0.00 C ATOM 12641 C2'CYT 5-16.888 14.729 6.003 1.00 0.00 C ATOM 12642 02'CYT 5-17.496 15.667 5.108 1.00 0.00 0 ATOM 12643 C3'CYT 5-16.865 15.248 7.427 1.00 0.00 C ATOM 12644 03'CYT 5-18.038 16.036 7.651 1.00 0.00 0 ATOM 12645 1H5'CYT 5-14.224 17.032 8.739 1.00 0.00 H ATOM 12646 2H5'CYT 5-15.863 16.896 9.408 1.00 0.00 H ATOM 12647 H4'CYT 5-15.938 17.125 6.955 1.00 0.00 H ATOM 12648 H1'CYT 5-15.206 14.802 4.664 1.00 0.00 H ATOM 12649 H6 CYT 5-14.477 13.556 8.021 1.00 0.00 H ATOM 12650 1H4 CYT 5-13.867 8.685 5. 832 1.00 0.00 H ATOM 12651 2H4 CYT 5-13.483 9.061 7.497 1.00 0.00 H ATOM 12652 H5 CYT 5-13.763 11.259 8.451 1.00 0.00 H ATOM 12653 H2'CYT 5-17.389 13.759 5.961 1.00 0.00 H ATOM 12654 H02'CYT 5-18.274 16.017 5.548 1.00 0.00 H ATOM 12655 H3'CYT 5-16.751 14.443 8.154 1.00 0.00 H ATOM 12656 P URI 6-19.332 15.395 8.366 1.00 0.00 P ATOM 12657 01P URI 6-20.348 16.459 8.524 1.00 0.00 0 ATOM 12658 02P URI 6-18.876 14.628 9.547 1.00 0.00 0 ATOM 12659 05'URI 6-19.860 14.350 7.260 1.00 0.00 0 ATOM 12660 C5'URI 6-20.489 14.814 6.061 1.00 0.00 C ATOM 12661 C4'URI 6-20.581 13.710 5. 011 1.00 0.00 C ATOM 12662 04'URI 6-19.290 13.180 4.682 1.00 0.00 0 ATOM 12663 Cl'URI 6-19.375 11.745 4.569 1.00 0.00 C ATOM 12664 N1 URI 6-18.620 11.072 5.653 1.00 0.00 N ATOM 12665 C6 URI 6-18.492 11.645 6.891 1.00 0.00 C ATOM 12666 C2 URI 6-18.044 9.846 5.363 1.00 0.00 C ATOM 12667 02 URI 6-18.154 9.314 4.261 1.00 0.00 0 ATOM 12668 N3 URI 6-17.338 9.248 6.391 1.00 0.00 N ATOM 12669 C4 URI 6-17.160 9.757 7.665 1.00 0.00 C ATOM 12670 04 URI 6-16.509 9.136 8.502 1.00 0.00 0 ATOM 12671 C5 URI 6-17.795 11.037 7.881 1.00 0.00 C ATOM 12672 C2'URI 6-20.859 11.411 4.634 1.00 0.00 C ATOM 12673 02'URI 6-21.465 11.455 3.336 1.00 0.00 0 ATOM 12674 C3'URI 6-21.370 12.520 5.529 1.00 0.00 C ATOM 12675 03'URI 6-22.759 12.735 5.256 1.00 0.00 0 ATOM 12676 1H5'URI 6-19.912 15.644 5.653 1.00 0.00 H ATOM 12677 2H5'URI 6-21.494 15.162 6.299 1.00 0.00 H ATOM 12678 H4'URI 6-21.052 14.098 4.110 1.00 0.00 H ATOM 12679 H1'URI 6-18.980 11.433 3.604 1.00 0.00 H ATOM 12680 H6 URI 6-18.960 12.610 7.084 1.00 0.00 H ATOM 12681 H3 URI 6-16.911 8.355 6.192 1.00 0.00 H ATOM 12682 H5 URI 6-17.712 11.521 8.854 1.00 0.00 H ATOM 12683 H2'URI 6-21.007 10.437 5.104 1.00 0.00 H ATOM 12684 H02'URI 6-21.101 10.728 2.826 1.00 0.00 H ATOM 12685 H3'URI 6-21.172 12.319 6.583 1.00 0.00 H ATOM 12686 P CYT 7-23.888 12.122 6.227 1.00 0.00 P ATOM 12687 O1P CYT 7-23.452 12.321 7.627 1.00 0.00 0 ATOM 12688 02P CYT 7-25.205 12.631 5.784 1.00 0.00 0 ATOM 12689 05'CYT 7-23.817 10.546 5.898 1. 00 0.00 0 ATOM 12690 C5'CYT 7-24.256 10. 046 4.631 1.00 0.00 C ATOM 12691 C4'CYT 7-23.679 8.662 4.338 1.00 0.00 C

ATOM 12692 04'CYT 7-22.246 8.667 4.387 1.00 0.00 0 ATOM 12693 Cl'CYT 7-21.785 7.472 5.050 1.00 0.00 C ATOM 12694 N1 CYT 7-21.152 7.778 6.353 1.00 0.00 N ATOM 12695 C6 CYT 7-21.378 8.964 6.992 1.00 0.00 C ATOM 12696 C2 CYT 7-20. 328 6.808 6.902 1.00 0.00 C ATOM 12697 02 CYT 7-20.142 5.748 6.308 1.00 0.00 0 ATOM 12698 N3 CYT 7-19.742 7.061 8.104 1.00 0.00 N ATOM 12699 C4 CYT 7-19.955 8.217 8.742 1.00 0.00 C ATOM 12700 N4 CYT 7-19.368 8.430 9.919 1.00 0.00 N ATOM 12701 C5 CYT 7-20.803 9.223 8.181 1.00 0.00 C ATOM 12702 C2'CYT 7-23.018 6.598 5.238 1.00 0.00 C ATOM 12703 02'CYT 7-23.247 5.761 4.098 1.00 0.00 0 ATOM 12704 C3'CYT 7-24.099 7.647 5.389 1.00 0.00 C ATOM 12705 03'CYT 7-25.352 7.072 5.007 1.00 0.00 0 ATOM 12706 1H5'CYT 7-23.939 10.734 3.847 1.00 0.00 H ATOM 12707 2H5'CYT 7-25.344 9.984 4.631 1.00 0.00 H ATOM 12708 H4'CYT 7-24.004 8.328 3.354 1.00 0.00 H ATOM 12709 Hl'CYT 7-21.069 6.955 4.410 1.00 0.00 H ATOM 12710 H6 CYT 7-22.026 9.709 6.533 1.00 0.00 H ATOM 12711 1H4 CYT 7-19.522 9.299 10.411 1.00 0.00 H ATOM 12712 2H4 CYT 7-18.767 7.723 10.319 1.00 0.00 H ATOM 12713 H5 CYT 7-20.977 10.166 8.698 1.00 0.00 H ATOM 12714 H2'CYT 7-22.928 6.005 6.152 1.00 0.00 H ATOM 12715 H02'CYT 7-24.145 5.426 4.165 1.00 0.00 H ATOM 12716 H3'CYT 7-24.116 8.075 6.392 1.00 0.00 H ATOM 12717 P ADE 8-26.317 6.412 6.117 1.00 0.00 P ATOM 12718 01P ADE 8-26.562 7.419 7.174 1.00 0.00 0 ATOM 12719 02P ADE 8-27.460 5.781 5.420 1.00 0.00 0 ATOM 12720 05'ADE 8-25.394 5.246 6.738 1.00 0.00 0 ATOM 12721 C5'ADE 8-25.295 3. 968 6.100 1.00 0.00 C ATOM 12722 C4'ADE 8-24.535 2.965 6.967 1.00 0.00 C ATOM 12723 04'ADE 8-23.170 3.367 7.172 1.00 0.00 0 ATOM 12724 C1'ADE 8-22.860 3.297 8.576 1.00 0.00 C ATOM 12725 N9 ADE 8-22.840 4.645 9.185 1.00 0.00 N ATOM 12726 C4 ADE 8-22.180 5. 028 10.333 1.00 0.00 C ATOM 12727 N3 ADE 8-21.439 4.237 11.135 1.00 0.00 N ATOM 12728 C2 ADE 8-20.940 4.923 12.162 1.00 0.00 C ATOM 12729 N1 ADE 8-21.108 6.219 12.424 1.00 0.00 N ATOM 12730 C6 ADE 8-21. 852 6.987 11.610 1.00 0.00 C ATOM 12731 N6 ADE 8-22.008 8.280 11.889 1.00 0.00 N ATOM 12732 C5 ADE 8-22.429 6.372 10.495 1.00 0.00 C ATOM 12733 N7 ADE 8-23.241 6.855 9.466 1.00 0.00 N ATOM 12734 C8 ADE 8-23.428 5.791 8.761 1.00 0.00 C ATOM 12735 C2'ADE 8-23.949 2.431 9.182 1.00 0.00 C ATOM 12736 02'ADE 8-23.675 1.035 9.004 1.00 0.00 0 ATOM 12737 C3'ADE 8-25.137 2.878 8.362 1.00 0.00 C ATOM 12738 03'ADE 8-26.133 1.852 8.382 1.00 0.00 0 ATOM 12739 1H5'ADE 8-24.775 4.082 5.149 1.00 0.00 H ATOM 12740 2H5'ADE 8-26.299 3.586 5.913 1.00 0.00 H ATOM 12741 H4'ADE 8-24.555 1.982 6.496 1.00 0.00 H ATOM 12742 Hl'ADE 8-21.896 2.817 8.716 1.00 0.00 H ATOM 12743 H2 ADE 8-20.327 4.362 12.868 1.00 0.00 H ATOM 12744 1H6 ADE 8-21.569 8.676 12.708 1.00 0.00 H ATOM 12745 2H6 ADE 8-22.565 8.864 11.283 1.00 0.00 H ATOM 12746 H8 ADE 8-24.041 5.812 7.861 1.00 0.00 H ATOM 12747 H2'ADE 8-24.089 2.677 10.236 1.00 0.00 H ATOM 12748 H02'ADE 8-24.492 0.561 9.172 1.00 0.00 H ATOM 12749 H3'ADE 8-25. 518 3.839 8.700 1.00 0.00 H ATOM 12750 P ADE 9-27.691 2.232 8.233 1.00 0.00 P ATOM 12751 01P ADE 9-28.495 1.093 8.731 1.00 0.00 O

ATOM 12752 02P ADE 9-27.914 2.749 6.864 1.00 0.00 0 ATOM 12753 05'ADE 9-27.855 3.458 9.269 1.00 0.00 0 ATOM 12754 C5'ADE 9-29. 146 4.012 9.546 1.00 0.00 C ATOM 12755 C4'ADE 9-29.052 5.332 10.316 1.00 0.00 C ATOM 12756 04'ADE 9-28.342 5.178 11.550 1.00 0.00 0 ATOM 12757 C1'ADE 9-27.021 5.738 11.430 1.00 0.00 C ATOM 12758 N9 ADE 9-26.005 4.768 11.880 1.00 0.00 N ATOM 12759 C4 ADE 9-25.003 4.989 12.795 1.00 0.00 C ATOM 12760 N3 ADE 9-24.742 6.148 13.426 1.00 0.00 N ATOM 12761 C2 ADE 9-23.708 6.025 14.249 1.00 0.00 C ATOM 12762 N1 ADE 9-22.976 4.933 14.472 1.00 0.00 N ATOM 12763 C6 ADE 9-23.256 3.787 13.830 1.00 0.00 C ATOM 12764 N6 ADE 9-22.514 2.705 14.068 1.00 0.00 N ATOM 12765 C5 ADE 9-24.330 3.797 12. 934 1.00 0.00 C ATOM 12766 N7 ADE 9-24.889 2.814 12.116 1.00 0.00 N ATOM 12767 C8 ADE 9-25.847 3.465 11.547 1.00 0.00 C ATOM 12768 C2'ADE 9-26.843 6.091 9.957 1.00 0.00 C ATOM 12769 02'ADE 9-25.998 7.234 9.784 1.00 0.00 0 ATOM 12770 C3'ADE 9-28.270 6.380 9.537 1.00 0.00 C ATOM 12771 03'ADE 9-28.627 7.685 10.023 1.00 0.00 0 ATOM 12772 lH5'ADE 9-29.718 3.298 10.139 1.00 0.00 H ATOM 12773 2H5'ADE 9-29.667 4.188 8.605 1.00 0.00 H ATOM 12774 H4'ADE 9-30.055 5.701 10.523 1.00 0.00 H ATOM 12775 Hl'ADE 9-26.949 6.647 12.030 1.00 0.00 H ATOM 12776 H2 ADE 9-23.432 6.913 14.811 1.00 0.00 H ATOM 12777 1H6 ADE 9-22.717 1.839 13.590 1.00 0.00 H ATOM 12778 2H6 ADE 9-21.749 2.752 14.727 1.00 0.00 H ATOM 12779 H8 ADE 9-26.500 2.987 10.820 1.00 0.00 H ATOM 12780 H2'ADE 9-26.462 5.231 9.407 1.00 0.00 H ATOM 12781 H02'ADE 9-26.082 7.514 8.869 1.00 0.00 H ATOM 12782 H3'ADE 9-28.412 6.283 8.462 1.00 0.00 H ATOM 12783 P URI 10-30.119 8.274 9. 838 1.00 0.00 P ATOM 12784 O1P URI 10-30.015 9.593 9.176 1.00 0.00 0 ATOM 12785 02P URI 10-30.973 7.218 9.248 1.00 0.00 0 ATOM 12786 05'URI 10-30.590 8.512 11.361 1.00 0.00 0 ATOM 12787 C5'URI 10-30. 434 7.480 12.340 1.00 0.00 C ATOM 12788 C4'URI 10-30.366 8.043 13.757 1.00 0.00 C ATOM 12789 04'URI 10-29.372 9.071 13.863 1.00 0.00 0 ATOM 12790 C1'URI 10-30.011 10.353 14.009 1.00 0.00 C ATOM 12791 N1 URI 10-29.418 11.355 13.095 1.00 0.00 N ATOM 12792 C6 URI 10-28.795 10.973 11.936 1.00 0.00 C ATOM 12793 C2 URI 10-29.520 12.689 13.453 1.00 0.00 C ATOM 12794 02 URI 10-30.074 13.052 14.489 1.00 0.00 0 ATOM 12795 N3 URI 10-28.959 13.598 12.575 1.00 0.00 N ATOM 12796 C4 URI 10-28.314 13.297 11.387 1.00 0.00 C ATOM 12797 04 URI 10-27.853 14.191 10. 681 1.00 0.00 0 ATOM 12798 C5 URI 10-28.253 11.883 11.093 1.00 0.00 C ATOM 12799 C2'URI 10-31.485 10.124 13.691 1.00 0.00 C ATOM 12800 02'URI 10-32.329 11.037 14.401 1.00 0.00 0 ATOM 12801 C3'URI 10-31.674 8.698 14.169 1.00 0.00 C ATOM 12802 03'URI 10-31.738 8.699 15.602 1.00 0.00 0 ATOM 12803 1H5'URI 10-29.512 6.936 12.137 1.00 0.00 H ATOM 12804 2H5'URI 10-31.276 6.791 12.270 1.00 0.00 H ATOM 12805 H4'URI 10-30.128 7.243 14.453 1.00 0.00 H ATOM 12806 Hl'URI 10-29.911 10. 695 15.040 1.00 0.00 H ATOM 12807 H6 URI 10-28. 732 9.913 11.689 1.00 0.00 H ATOM 12808 H3 URI 10-29.027 14.575 12.823 1.00 0.00 H ATOM 12809 H5 URI 10-27.765 11.545 10.178 1.00 0.00 H ATOM 12810 H2'URI 10-31. 653 10.183 12. 612 1.00 0.00 H ATOM 12811 H02'URI 10-33.227 10.703 14.340 1.00 0.00 H

ATOM 12812 H3'URI 10-32.541 8.217 13.712 1.00 0.00 H ATOM 12813 P GUA 11-32. 094 7.355 16.422 1.00 0.00 P ATOM 12814 01P GUA 11-33. 453 6.919 16.027 1.00 0.00 0 ATOM 12815 02P GUA 11-31.784 7.592 17.850 1.00 0.00 0 ATOM 12816 05'GUA 11-31.029 6.285 15.850 1.00 0.00 0 ATOM 12817 C5'GUA 11-31.469 5.175 15.057 1.00 0.00 C ATOM 12818 C4'GUA 11-30.352 4.156 14.823 1.00 0.00 C ATOM 12819 04'GUA 11-29.241 4.722 14.115 1.00 0.00 0 ATOM 12820 Cl'GUA 11-28.012 4.207 14.671 1.00 0.00 C ATOM 12821 N9 GUA 11-27.249 5.270 15.349 1.00 0.00 N ATOM 12822 C4 GUA 11-26.087 5.114 16.065 1.00 0.00 C ATOM 12823 N3 GUA 11-25.454 3.944 16.300 1.00 0.00 N ATOM 12824 C2 GUA 11-24.346 4.107 17.026 1.00 0.00 C ATOM 12825 N2 GUA 11-23.604 3.051 17.353 1.00 0.00 N ATOM 12826 N1 GUA 11-23.902 5.333 17.478 1.00 0.00 N ATOM 12827 C6 GUA 11-24.533 6.548 17.250 1.00 0.00 C ATOM 12828 06 GUA 11-24.053 7.587 17.695 1.00 0.00 0 ATOM 12829 C5 GUA 11-25.714 6.383 16.481 1.00 0.00 C ATOM 12830 N7 GUA 11-26.634 7.336 16.035 1.00 0.00 N ATOM 12831 C8 GUA 11-27.480 6.602 15.395 1.00 0. 00 C ATOM 12832 C2'GUA 11-28.430 3.117 15.654 1.00 0.00 C ATOM 12833 02'GUA 11-28.586 1.852 15.001 1.00 0.00 0 ATOM 12834 C3'GUA 11-29.757 3.668 16.131 1.00 0.00 C ATOM 12835 03'GUA 11-30.557 2.594 16.635 1.00 0.00 0 ATOM 12836 1H5'GUA 11-31. 820 5.543 14.093 1.00 0.00 H ATOM 12837 2H5'GUA 11-32. 295 4.680 15.569 1.00 0.00 H ATOM 12838 H4'GUA 11-30.742 3.310 14.261 1.00 0.00 H ATOM 12839 H1'GUA 11-27.400 3.774 13.877 1.00 0.00 H ATOM 12840 1H2 GUA 11-22.765 3.173 17.902 1.00 0.00 H ATOM 12841 2H2 GUA 11-23.881 2.128 17.053 1.00 0.00 H ATOM 12842 HI GUA 11-23.052 5.372 18.022 1.00 0.00 H ATOM 12843 H8 GUA 11-28.352 7.035 14.912 1.00 0.00 H ATOM 12844 H2'GUA 11-27.718 3. 052 16.481 1.00 0.00 H ATOM 12845 H02'GUA 11-29.039 1.269 15.614 1.00 0.00 H ATOM 12846 H3'GUA 11-29.628 4.477 16.852 1.00 0.00 H ATOM 12847 P CYT 12-31.061 2.607 18.165 1.00 0.00 P ATOM 12848 01P CYT 12-31.532 3.973 18.488 1.00 0.00 0 ATOM 12849 02P CYT 12-31.961 1.449 18.366 1.00 0.00 0 ATOM 12850 05'CYT 12-29.700 2.337 18.980 1.00 0.00 0 ATOM 12851 C5'CYT 12-29.160 1.017 19.071 1.00 0.00 C ATOM 12852 C4'CYT 12-27.817 1.002 19.794 1.00 0.00 C ATOM 12853 04'CYT 12-26.832 1.781 19.109 1.00 0.00 0 ATOM 12854 C1'CYT 12-25.981 2.427 20.078 1.00 0.00 C ATOM 12855 N1 CYT 12-26.054 3.902 19.969 1.00 0.00 N ATOM 12856 C6 CYT 12-27.073 4.513 19.293 1.00 0.00 C ATOM 12857 C2 CYT 12-25.040 4.638 20.567 1.00 0.00 C ATOM 12858 02 CYT 12-24.145 4.068 21.188 1.00 0.00 0 ATOM 12859 N3 CYT 12-25. 077 5.993 20.461 1.00 0.00 N ATOM 12860 C4 CYT 12-26.066 6.606 19.800 1.00 0.00 C ATOM 12861 N4 CYT 12-26. 059 7.934 19.700 1.00 0.00 N ATOM 12862 C5 CYT 12-27.118 5.855 19.188 1.00 0.00 C ATOM 12863 C2'CYT 12-26.461 1.953 21.449 1.00 0.00 C ATOM 12864 02'CYT 12-25.746 0.790 21.881 1.00 0.00 0 ATOM 12865 C3'CYT 12-27.915 1.641 21.166 1.00 0.00 C ATOM 12866 03'CYT 12-28.374 0.659 22.099 1.00 0.00 0 ATOM 12867 1H5'CYT 12-29. 026 0.617 18.066 1.00 0.00 H ATOM 12868 2H5'CYT 12-29.862 0.384 19.614 1.00 0.00 H ATOM 12869 H4'CYT 12-27. 462-0. 022 19.891 1.00 0. 00 H ATOM 12870 H1'CYT 12-24.951 2.103 19.925 1.00 0.00 H ATOM 12871 H6 CYT 12-27.856 3.911 18.833 1.00 0.00 H

ATOM 12872 1H4 CYT 12-26.793 8.407 19.193 1.00 0.00 H ATOM 12873 2H4 CYT 12-25.316 8.469 20.130 1.00 0.00 H ATOM 12874 H5 CYT 12-27.931 6.353 18.661 1.00 0.00 H ATOM 12875 H2'CYT 12-26.377 2.760 22.179 1.00 0.00 H ATOM 12876 H02'CYT 12-25.789 0.149 21.167 1. 00 0.00 H ATOM 12877 H3'CYT 12-28.532 2.542 21.160 1.00 0.00 H ATOM 12878 P URI 13-29.405 1.065 23.268 1.00 0.00 P ATOM 12879 01P URI 13-29. 971-0.178 23.837 1.00 0.00 0 ATOM 12880 02P URI 13-30. 308 2.116 22.746 1.00 0.00 0 ATOM 12881 05'URI 13-28.439 1. 734 24.369 1.00 0.00 0 ATOM 12882 C5'URI 13-27.692 0.915 25.274 1.00 0.00 C ATOM 12883 C4'URI 13-26.672 1.731 26.062 1.00 0.00 C ATOM 12884 04'URI 13-25.729 2.375 25.195 1.00 0.00 0 ATOM 12885 C1'URI 13-25.468 3.708 25.675 1.00 0.00 C ATOM 12886 N1 URI 13-25.966 4.732 24.728 1.00 0.00 N ATOM 12887 C6 URI 13-26.965 4.448 23.833 1.00 0.00 C ATOM 12888 C2 URI 13-25.385 5.987 24.785 1.00 0.00 C ATOM 12889 02 URI 13-24.488 6.261 25.580 1.00 0.00 O ATOM 12890 N3 URI 13-25.871 6.921 23.893 1.00 0.00 N ATOM 12891 C4 URI 13-26.871 6. 719 22.959 1.00 0.00 C ATOM 12892 04 URI 13-27.222 7. 627 22.211 1.00 0.00 O ATOM 12893 C5 URI 13-27.422 5.383 22. 967 1. 00 0. 00 C ATOM 12894 C2'URI 13-26.176 3.817 27.022 1.00 0.00 C ATOM 12895 02'URI 13-25.327 3.400 28.097 1.00 0.00 O ATOM 12896 C3'URI 13-27.337 2.865 26.823 1.00 0.00 C ATOM 12897 03'URI 13-27. 759 2.379 28.102 1.00 0.00 0 ATOM 12898 lH5'URI 13-27.170 0.143 24.709 1.00 0.00 H ATOM 12899 2H5'URI 13-28. 381 0.439 25.972 1.00 0.00 H ATOM 12900 H4'URI 13-26.139 1.084 26.757 1.00 0.00 H ATOM 12901 Hl'URI 13-24. 395 3.837 25. 818 1.00 0.00 H ATOM 12902 H6 URI 13-27. 399 3.448 23.814 1.00 0.00 H ATOM 12903 H3 URI 13-25.459 7.842 23. 929 1.00 0.00 H ATOM 12904 H5 URI 13-28.217 5.125 22.268 1.00 0.00 H ATOM 12905 H2'URI 13-26.540 4.836 27.178 1.00 0.00 H ATOM 12906 H02'URI 13-25.886 3.263 28.865 1.00 0.00 H ATOM 12907 H3'URI 13-28.149 3.322 26.256 1.00 0.00 H ATOM 12908 P CYT 14-28.972 3.091 28. 887 1.00 0.00 P ATOM 12909 O1P CYT 14-30.052 3.372 27.915 1.00 0.00 O ATOM 12910 02P CYT 14-29.263 2.299 30.104 1.00 0.00 0 ATOM 12911 05'CYT 14-28.325 4.496 29.337 1.00 0.00 O ATOM 12912 C5'CYT 14-27.568 4.600 30.548 1.00 0.00 C ATOM 12913 C4'CYT 14-27.135 6.040 30.815 1.00 0.00 C ATOM 12914 04'CYT 14-26. 304 6. 540 29.763 1.00 0.00 0 ATOM 12915 C1'CYT 14-26.642 7. 913 29.488 1.00 0.00 C ATOM 12916 Nl CYT 14-27.153 8.080 28.111 1.00 0.00 N ATOM 12917 C6 CYT 14-27.828 7.073 27.484 1.00 0.00 C ATOM 12918 C2 CYT 14-26.929 9.300 27.488 1.00 0.00 C ATOM 12919 02 CYT 14-26.319 10.193 28.074 1.00 0.00 0 ATOM 12920 N3 CYT 14-27.401 9. 476 26.226 1.00 0.00 N ATOM 12921 C4 CYT 14-28.065 8.498 25.599 1.00 0.00 C ATOM 12922 N4 CYT 14-28.522 8.708 24.367 1.00 0.00 N ATOM 12923 C5 CYT 14-28.298 7.239 26.235 1.00 0.00 C ATOM 12924 C2'CYT 14-27.702 8.311 30.511 1.00 0.00 C ATOM 12925 02'CYT 14-27.114 8.928 31.663 1.00 0. 00 0 ATOM 12926 C3'CYT 14-28.331 6.975 30.852 1.00 0.00 C ATOM 12927 03'CYT 14-28.826 7.036 32.193 1.00 0.00 0 ATOM 12928 1H5'CYT 14-26.682 3.970 30.471 1.00 0.00 H ATOM 12929 2H5'CYT 14-28. 181 4.254 31.381 1.00 0.00 H ATOM 12930 H4'CYT 14-26.595 6.094 31.759 1.00 0.00 H ATOM 12931 Hl'CYT 14-25.758 8.536 29.623 1.00 0.00 H

ATOM 12932 H6 CYT 14-27.990 6.127 28. 000 1.00 0.00 H ATOM 12933 1H4 CYT 14-29.031 7.981 23.885 1.00 0.00 H ATOM 12934 2H4 CYT 14-28. 362 9.597 23.915 1.00 0.00 H ATOM 12935 H5 CYT 14-28.840 6.442 25. 727 1.00 0.00 H ATOM 12936 H2'CYT 14-28.442 8.970 30.049 1.00 0.00 H ATOM 12937 H02'CYT 14-26.492 8.299 32.036 1.00 0.00 H ATOM 12938 H3'CYT 14-29.099 6.690 30.132 1.00 0.00 H ATOM 12939 P URI 15-30.374 7.379 32.479 1.00 0.00 P ATOM 12940 01P URI 15-30.514 7.729 33.910 1.00 0.00 0 ATOM 12941 02P URI 15-31.201 6.296 31.900 1.00 0.00 0 ATOM 12942 05'URI 15-30. 610 8.712 31.605 1.00 0.00 0 ATOM 12943 C5'URI 15-30.154 9.988 32.066 1.00 0.00 C ATOM 12944 C4'URI 15-30.277 11.055 30.977 1.00 0.00 C ATOM 12945 04'URI 15-29.484 10.728 29.825 1.00 0.00 0 ATOM 12946 C1'URI 15-30. 269 10.911 28.631 1.00 0.00 C ATOM 12947 NI URI 15-30.660 9.612 28.043 1.00 0.00 N ATOM 12948 C6 URI 15-30.887 8.523 28.838 1.00 0.00 C ATOM 12949 C2 URI 15-30.797 9.543 26.668 1.00 0.00 C ATOM 12950 02 URI 15-30.597 10.510 25.937 1.00 0.00 0 ATOM 12951 N3 URI 15-31.175 8.314 26.159 1.00 0.00 N ATOM 12952 C4 URI 15-31.424 7.167 26.892 1.00 0.00 C ATOM 12953 04 URI 15-31.756 6.125 26.332 1.00 0.00 0 ATOM 12954 C5 URI 15-31.256 7.333 28.317 1.00 0. 00 C ATOM 12955 C2'URI 15-31. 492 11.707 29. 067 1.00 0.00 C ATOM 12956 02'URI 15-31.225 13.115 29.087 1.00 0.00 0 ATOM 12957 C3'URI 15-31.706 11.157 30.462 1.00 0.00 C ATOM 12958 03'URI 15-32.407 12.130 31.241 1.00 0.00 0 ATOM 12959 1H5'URI 15-29.109 9.907 32.368 1.00 0.00 H ATOM 12960 2H5'URI 15-30. 751 10.289 32.927 1.00 0.00 H ATOM 12961 H4'URI 15-29. 960 12.019 31.371 1.00 0.00 H ATOM 12962 H1'URI 15-29.697 11.488 27.903 1.00 0.00 H ATOM 12963 H6 URI 15-30. 762 8.614 29.916 1.00 0.00 H ATOM 12964 H3 URI 15-31. 280 8.248 25.157 1.00 0.00 H ATOM 12965 H5 URI 15-31.431 6.490 28.982 1.00 0.00 H ATOM 12966 H2'URI 15-32. 350 11.476 28.427 1.00 0.00 H ATOM 12967 H02'URI 15-31.008 13.378 28.189 1.00 0.00 H ATOM 12968 H3'URI 15-32. 208 10.186 30.445 1. 00 0.00 H ATOM 12969 P URI 16-33.992 12.342 31.056 1.00 0.00 P ATOM 12970 01P URI 16-34.610 11.025 30.786 1.00 0. 00 0 ATOM 12971 02P URI 16-34.481 13.169 32.182 1.00 0. 00 0 ATOM 12972 05'URI 16-34.075 13.223 29.710 1.00 0. 00 0 ATOM 12973 C5'URI 16-35.311 13.824 29.313 1.00 0.00 C ATOM 12974 C4'URI 16-35.199 15.339 29.229 1.00 0.00 C ATOM 12975 04'URI 16-34.625 15.886 30.426 1.00 0.00 0 ATOM 12976 C1'URI 16-33. 518 16.725 30.086 1.00 0.00 C ATOM 12977 N1 URI 16-32.471 16.683 31.130 1.00 0.00 N ATOM 12978 C6 URI 16-32.002 15.488 31.610 1. 00 0.00 C ATOM 12979 C2 URI 16-31.982 17.890 31.599 1.00 0.00 C ATOM 12980 02 URI 16-32. 390 18.972 31.180 1.00 0.00 0 ATOM 12981 N3 URI 16-31.002 17.811 32.571 1.00 0.00 N ATOM 12982 C4 URI 16-30.475 16.650 33.109 1.00 0.00 C ATOM 12983 04 URI 16-29.602 16.700 33.973 1.00 0. 00 0 ATOM 12984 C5 URI 16-31. 042 15.438 32.563 1.00 0.00 C ATOM 12985 C2'URI 16-32.997 16.182 28.768 1.00 0.00 C ATOM 12986 02'URI 16-32.305 17.187 28.020 1.00 0. 00 O ATOM 12987 C3'URI 16-34.282 15.755 28.079 1.00 0.00 C ATOM 12988 03'URI 16-34.863 16.896 27.440 1.00 0.00 0 ATOM 12989 1H5'URI 16-36.080 13.561 30. 027 1.00 0.00 H ATOM 12990 2H5'URI 16-35.597 13.442 28.339 1. 00 O. flO H ATOM 12991 H4'URI 16-36.189 15. 768 29.078 1.00 0.00 H

ATOM 12992 Hl'URI 16-33.863 17.750 29.949 1.00 0.00 H ATOM 12993 H6 URI 16-32.410 14.558 31.215 1.00 0.00 H ATOM 12994 H3 URI 16-30.636 18.684 32.922 1.00 0.00 H ATOM 12995 H5 URI 16-30.690 14.471 32.922 1.00 0.00 H ATOM 12996 H2'URI 16-32.360 15.311 28.943 1.00 0.00 H ATOM 12997 H02'URI 16-32.931 17. 894 27.846 1.00 0.00 H ATOM 12998 H3'URI 16-34.114 14.936 27. 377 1.00 0.00 H ATOM 12999 P CYT 17-36.099 16.710 26.423 1.00 0.00 P ATOM 13000 01P CYT 17-36.316 17.993 25.717 1.00 0.00 0 ATOM 13001 02P CYT 17-37.215 16.072 27.155 1.00 0.00 0 ATOM 13002 05'CYT 17-35.514 15.643 25.366 1.00 0. 00 0 ATOM 13003 C5'CYT 17-34.412 15.997 24. 529 1.00 0.00 C ATOM 13004 C4'CYT 17-33.823 14.790 23. 811 1.00 0.00 C ATOM 13005 04'CYT 17-33.414 13.775 24.741 1.00 0.00 0 ATOM 13006 C1'CYT 17-33.931 12.521 24.304 1.00 0.00 C ATOM 13007 N1 CYT 17-34.118 11.585 25.427 1.00 0.00 N ATOM 13008 C6 CYT 17-34.738 11.986 26.565 1.00 0.00 C ATOM 13009 C2 CYT 17-33.628 10.294 25.282 1.00 0.00 C ATOM 13010 02 CYT 17-33.070 9.957 24.239 1.00 0.00 0 ATOM 13011 N3 CYT 17-33.782 9.427 26. 318 1.00 0.00 N ATOM 13012 C4 CYT 17-34.389 9.808 27. 448 1.00 0.00 C ATOM 13013 N4 CYT 17-34.517 8.936 28.448 1.00 0.00 N ATOM 13014 C5 CYT 17-34.894 11.138 27. 596 1.00 0.00 C ATOM 13015 C2'CYT 17-35.245 12.870 23.636 1.00 0.00 C ATOM 13016 02'CYT 17-35.678 11.838 22.742 1.00 0.00 0 ATOM 13017 C3'CYT 17-34.857 14.138 22.891 1.00 0.00 C ATOM 13018 03'CYT 17-34.198 13.757 21.677 1.00 0.00 O ATOM 13019 1H5'CYT 17-33.638 16.456 25.136 1.00 0.00 H ATOM 13020 2H5'CYT 17-34. 753 16.715 23.788 1.00 0.00 H ATOM 13021 H4'CYT 17-32.963 15.104 23.221 1.00 0.00 H ATOM 13022 H1'CYT 17-33. 256 12. 087 23.577 1.00 0.00 H, ATOM 13023 H6 CYT 17-35.115 13.004 26.638 1.00 0.00 H ATOM 13024 1H4 CYT 17-34.969 9.216 29.307 1.00 0.00 H ATOM 13025 2H4 CYT 17-34.161 7.996 28. 348 1.00 0.00 H ATOM 13026 H5 CYT 17-35.383 11.456 28.513 1.00 0.00 H ATOM 13027 H2'CYT 17-36. 007 13.093 24.388 1.00 0.00 H ATOM 13028 H02'CYT 17-34.964 11.683 22.120 1.00 0.00 H ATOM 13029 H3'CYT 17-35.710 14. 791 22.714 1.00 0.00 H ATOM 13030 P GUA 18-34.406 14.608 20.324 1.00 0.00 P ATOM 13031 01P GUA 18-33.686 13.918 19.229 1.00 0.00 0 ATOM 13032 02P GUA 18-35.848 14.910 20.182 1.00 0.00 0 ATOM 13033 05'GUA 18-33.633 15.985 20.647 1.00 0.00 0 ATOM 13034 C5'GUA 18-32.203 16.028 20.685 1.00 0.00 C ATOM 13035 C4'GUA 18-31. 699 17.313 21.335 1.00 0.00 C ATOM 13036 04'GUA 18-32.160 17. 428 22.686 1.00 0. 00 0 ATOM 13037 Cl'GUA 18-31.101 17.923 23.524 1.00 0.00 C ATOM 13038 N9 GUA 18-30.703 16.922 24.536 1. 00 0.00 N ATOM 13039 C4 GUA 18-30.644 15.552 24.374 1.00 0.00 C ATOM 13040 N3 GUA 18-30.926 14.872 23.238 1.00 0.00 N ATOM 13041 C2 GUA 18-30.781 13.551 23.391 1. 00 0.00 C ATOM 13042 N2 GUA 18-31.018 12.732 22.367 1.00 0.00 N ATOM 13043 N1 GUA 18-30.388 12.956 24.573 1.00 0.00 N ATOM 13044 C6 GUA 18-30.092 13. 633 25.749 1.00 0.00 C ATOM 13045 06 GUA 18-29.742 13. 010 26.748 1.00 0. 00 0 ATOM 13046 C5 GUA 18-30. 244 15.035 25.596 1.00 0. 00 C ATOM 13047 N7 GUA 18-30.048 16.060 26.525 1.00 0.00 N ATOM 13048 C8 GUA 18-30.335 17.106 25.828 1.00 0.00 C ATOM 13049 C2'GUA 18-29. 939 18.264 22.595 1.00 0.00 C ATOM 13050 02'GUA 18-29.984 19. 636 22.183 1.00 0.00 0 ATOM 13051 C3'GUA 18-30.182 17. 323 21.429 1.00 0.00 C

ATOM 13052 03'GUA 18-29.653 17.924 20.241 1.00 0.00 0 ATOM 13053 1H5'GUA 18-31.817 15.969 19.667 1.00 0.00 H ATOM 13054 2H5'GUA 18-31.836 15.174 21.255 1.00 0.00 H ATOM 13055 H4'GUA 18-32.038 18.175 20.762 1.00 0.00 H ATOM 13056 H1'GUA 18-31.438 18.830 24. 029 1.00 0.00 H ATOM 13057 1H2 GUA 18-30. 908 11.735 22.482 1.00 0.00 H ATOM 13058 2H2 GUA 18-31.307 13.109 21.476 1.00 0.00 H ATOM 13059 H1 GUA 18-30. 305 11.949 24.609 1.00 0.00 H ATOM 13060 H8 GUA 18-30.282 18.105 26.262 1.00 0.00 H ATOM 13061 H2'GUA 18-28.987 18.032 23.079 1.00 0.00 H ATOM 13062 H02'GUA 18-30.836 19.782 21.767 1.00 0.00 H ATOM 13063 H3'GUA 18-29.776 16.329 21.615 1.00 0.00 H ATOM 13064 P GUA 19-28.368 17.295 19.499 1.00 0.00 P ATOM 13065 01P GUA 19-28.646 15.869 19.222 1.00 0.00 O ATOM 13066 02P GUA 19-27. 983 18.200 18.392 1.00 0.00 0 ATOM 13067 05'GUA 19-27. 227 17.374 20.636 1.00 0.00 0 ATOM 13068 C5'GUA 19-26. 637 18.627 20.998 1.00 0.00 C ATOM 13069 C4'GUA 19-26. 059 18.591 22.413 1.00 0.00 C ATOM 13070 04'GUA 19-27. 043 18.178 23.378 1.00 0.00 0 ATOM 13071 C1'GUA 19-26.486 17.149 24.217 1.00 0.00 C ATOM 13072 N9 GUA 19-26.988 15.813 23.834 1.00 0.00 N ATOM 13073 C4 GUA 19-26.917 14.658 24.582 1.00 0.00 C ATOM 13074 N3 GUA 19-26.389 14.543 25.822 1.00 0.00 N ATOM 13075 C2 GUA 19-26. 464 13.291 26. 288 1.00 0.00 C ATOM 13076 N2 GUA 19-25.986 13.000 27.498 1.00 0.00 N ATOM 13077 N1 GUA 19-27.018 12.243 25.581 1.00 0.00 N ATOM 13078 C6 GUA 19-27.565 12.337 24.310 1.00 0.00 C ATOM 13079 06 GUA 19-28.039 11.343 23.767 1.00 0.00 0 ATOM 13080 C5 GUA 19-27.489 13.661 23.807 1.00 0.00 C ATOM 13081 N7 GUA 19-27.920 14.175 22.582 1.00 0.00 N ATOM 13082 C8 GUA 19-27.590 15.415 22.688 1.00 0.00 C ATOM 13083 C2'GUA 19-24.984 17.239 24.007 1.00 0.00 C ATOM 13084 02'GUA 19-24.400 18.279 24.802 1.00 0.00 0 ATOM 13085 C3'GUA 19-24. 939 17.566 22.530 1.00 0. 00 C ATOM 13086 03'GUA 19-23. 692 18.202 22.235 1.00 0.00 0 ATOM 13087 1H5'GUA 19-27. 395 19.407 20.944 1.00 0.00 H ATOM 13088 2H5'GUA 19-25.838 18.859 20.294 1.00 0.00 H ATOM 13089 H4'GUA 19-25.683 19.577 22.681 1.00 0.00 H ATOM 13090 H1'GUA 19-26.727 17.351 25.261 1.00 0.00 H ATOM 13091 1H2 GUA 19-25.567 13.724 28.063 1.00 0.00 H ATOM 13092 2H2 GUA 19-26. 043 12.054 27.849 1.00 0.00 H ATOM 13093 Hl GUA 19-27. 037 11.325 26.003 1.00 0.00 H ATOM 13094 H8 GUA 19-27.782 16.120 21.880 1.00 0.00 H ATOM 13095 H2'GUA 19-24.513 16.274 24.205 1.00 0.00 H ATOM 13096 H02'GUA 19-24. 453 18.000 25.719 1.00 0.00 H ATOM 13097 H3'GUA 19-25.120 16.685 21.912 1.00 0.00 H ATOM 13098 P ADE 20-22.430 17.325 21.754 1.00 0.00 P ATOM 13099 01P ADE 20-22. 860 16.471 20.625 1.00 0.00 0 ATOM 13100 02P ADE 20-21.270 18.231 21.593 1.00 0.00 0 ATOM 13101 05'ADE 20-22.159 16.377 23. 027 1.00 0.00 0 ATOM 13102 C5'ADE 20-21.495 16.886 24.186 1.00 0.00 C ATOM 13103 C4'ADE 20-21.308 15.804 25.246 1.00 0.00 C ATOM 13104 04'ADE 20-22.564 15.298 25.721 1.00 0.00 0 ATOM 13105 C1'ADE 20-22.483 13.864 25.845 1.00 0.00 C ATOM 13106 N9 ADE 20-23.320 13.190 24.831 1.00 0.00 N ATOM 13107 C4 ADE 20-23.721 11.872 24.838 1.00 0.00 C ATOM 13108 N3 ADE 20-23. 408 10.945 25.766 1.00 0.00 N ATOM 13109 C2 ADE 20-23.955 9.768 25.477 1.00 0.00 C ATOM 13110 N1 ADE 20-24.724 9.474 24.428 1.00 0.00 N ATOM 13111 C6 ADE 20-25.023 10.416 23.517 1.00 0.00 C

ATOM 13112 N6 ADE 20-25.808 10.105 22.486 1.00 0.00 N ATOM 13113 C5 ADE 20-24.497 11.695 23.717 1.00 0.00 C ATOM 13114 N7 ADE 20-24.598 12.883 22.988 1.00 0.00 N ATOM 13115 C8 ADE 20-23.888 13.687 23.704 1.00 0.00 C ATOM 13116 C2'ADE 20-21.012 13.517 25.656 1.00 0.00 C ATOM 13117 02'ADE 20-20.285 13.612 26.887 1.00 0.00 O ATOM 13118 C3'ADE 20-20.596 14.590 24.675 1.00 0.00 C ATOM 13119 03'ADE 20-19.184 14.788 24.772 1.00 0.00 0 ATOM 13120 1H5'ADE 20-22.085 17.700 24.608 1.00 0.00 H ATOM 13121 2H5'ADE 20-20.517 17.269 23.895 1.00 0.00 H ATOM 13122 H4'ADE 20-20.739 16.203 26.084 1.00 0.00 H ATOM 13123 H1'ADE 20-22.804 13.565 26.844 1.00 0.00 H ATOM 13124 H2 ADE 20-23.749 8.952 26.171 1.00 0.00 H ATOM 13125 1H6 ADE 20-26.047 10.810 21.803 1.00 0.00 H ATOM 13126 2H6 ADE 20-26.168 9.166 22.390 1.00 0.00 H ATOM 13127 H8 ADE 20-23.740 14.724 23.408 1.00 0.00 H ATOM 13128 H2'ADE 20-20.909 12.526 25.210 1.00 0.00 H ATOM 13129 H02'ADE 20-19.351 13.615 26.667 1.00 0.00 H ATOM 13130 H3'ADE 20-20.923 14.363 23.659 1.00 0.00 H ATOM 13131 P GUA 21-18.190 14.018 23.767 1.00 0.00 P ATOM 13132 O1P GUA 21-16.812 14.496 24.022 1.00 0.00 0 ATOM 13133 02P GUA 21-18. 757 14.098 22.402 1.00 0.00 0 ATOM 13134 05'GUA 21-18.299 12.492 24.269 1.00 0.00 0 ATOM 13135 C5'GUA 21-17.554 12.043 25.405 1.00 0.00 C ATOM 13136 C4'GUA 21-17. 704 10.540 25.613 1.00 0.00 C ATOM 13137 04'GUA 21-19.060 10.174 25.900 1.00 0.00 O ATOM 13138 C1'GUA 21-19.397 8.975 25.176 1.00 0.00 C ATOM 13139 N9 GUA 21-20.401 9.250 24.129 1.00 0.00 N ATOM 13140 C4 GUA 21-21. 235 8.332 23.535 1.00 0.00 C ATOM 13141 N3 GUA 21-21.251 7.003 23.779 1.00 0.00 N ATOM 13142 C2 GUA 21-22.170 6.367 23.048 1.00 0.00 C ATOM 13143 N2 GUA 21-22. 302 5.044 23.148 1.00 0.00 N ATOM 13144 N1 GUA 21-23.008 7.000 22. 153 1.00 0.00 N ATOM 13145 C6 GUA 21-23.012 8.362 21.886 1.00 0.00 C ATOM 13146 06 GUA 21-23.808 8.829 21.076 1.00 0.00 0 ATOM 13147 C5 GUA 21-22.034 9.045 22.655 1.00 0.00 C ATOM 13148 N7 GUA 21-21.709 10.404 22.686 1.00 0.00 N ATOM 13149 C8 GUA 21-20.759 10.426 23.559 1.00 0.00 C ATOM 13150 C2'GUA 21-18. 092 8.472 24.569 1.00 0.00 C ATOM 13151 02'GUA 21-17.390 7.607 25.470 1.00 0.00 O ATOM 13152 C3'GUA 21-17.352 9.775 24.350 1.00 0.00 C ATOM 13153 03'GUA 21-15. 944 9.520 24.347 1.00 0.00 0 ATOM 13154 1H5'GUA 21-17.909 12.563 26.294 1.00 0.00 H ATOM 13155 2H5'GUA 21-16.500 12.277 25. 252 1.00 0.00 H ATOM 13156 H4'GUA 21-17.062 10.215 26.430 1.00 0.00 H ATOM 13157 Hl'GUA 21-19.791 8.230 25.868 1.00 0.00 H ATOM 13158 1H2 GUA 21-21.708 4.524 23.778 1.00 0.00 H ATOM 13159 2H2 GUA 21-22.992 4.562 22.591 1.00 0.00 H ATOM 13160 H1 GUA 21-23.680 6.448 21.640 1.00 0.00 H ATOM 13161 H8 GUA 21-20.252 11.354 23.817 1.00 0.00 H ATOM 13162 H2'GUA 21-18.284 7.976 23.615 1.00 0.00 H ATOM 13163 H02'GUA 21-17.874 6.779 25.506 1.00 0.00 H ATOM 13164 H3'GUA 21-17.690 10.290 23.450 1.00 0.00 H ATOM 13165 P ADE 22-15.132 9.448 22.958 1.00 0.00 P ATOM 13166 O1P ADE 22-13.687 9.557 23.261 1.00 0.00 O ATOM 13167 02P ADE 22-15.757 10.391 22.004 1.00 0.00 0 ATOM 13168 05'ADE 22-15.432 7.950 22.455 1.00 0.00 0 ATOM 13169 C5'ADE 22-14.778 6.835 23.067 1.00 0.00 C ATOM 13170 C4'ADE 22-15.437 5.515 22.680 1.00 0.00 C ATOM 13171 04'ADE 22-16.817 5.479 23.070 1.00 0.00 O

ATOM 13172 Cl'ADE 22-17.599 4.902 22.006 1.00 0.00 C ATOM 13173 N9 ADE 22-18.468 5.910 21.370 1.00 0.00 N ATOM 13174 C4 ADE 22-19.650 5.670 20.711 1.00 0.00 C ATOM 13175 N3 ADE 22-20.235 4.469 20.536 1.00 0.00 N ATOM 13176 C2 ADE 22-21.369 4.580 19.855 1.00 0.00 C ATOM 13177 Nl ADE 22-21.916 5.700 19.378 1.00 0.00 N ATOM 13178 C6 ADE 22-21. 312 6.886 19.566 1.00 0.00 C ATOM 13179 N6 ADE 22-21.871 7.993 19.080 1.00 0.00 N ATOM 13180 C5 ADE 22-20.107 6.889 20.272 1.00 0.00 C ATOM 13181 N7 ADE 22-19.230 7.913 20.643 1.00 0.00 N ATOM 13182 C8 ADE 22-18.315 7.255 21.271 1.00 0.00 C ATOM 13183 C2'ADE 22-16.594 4 : 345 21.007 1.00 0.00 C ATOM 13184 02'ADE 22-16.204 3.009 21.346 1.00 0.00 0 ATOM 13185 C3'ADE 22-15.452 5.324 21.173 1.00 0.00 C ATOM 13186 03'ADE 22-14.235 4.688 20.772 1.00 0.00 0 ATOM 13187 1H5'ADE 22-14.819 6.948 24.151 1.00 0.00 H ATOM 13188 2H5'ADE 22-13.735 6.817 22.751 1.00 0.00 H ATOM 13189 H4'ADE 22-14.908 4.687 23.150 1.00 0.00 H ATOM 13190 Hl'ADE 22-18.209 4.090 22.401 1.00 0.00 H ATOM 13191 H2 ADE 22-21.910 3.653 19.660 1.00 0.00 H ATOM 13192 1H6 ADE 22-21.422 8.887 19.216 1.00 0.00 H ATOM 13193 2H6 ADE 22-22.746 7.938 18.577 1.00 0.00 H ATOM 13194 H8 ADE 22-17.452 7.760 21.703 1.00 0.00 H ATOM 13195 H2'ADE 22-16.998 4.395 19.992 1.00 0.00 H ATOM 13196 H02'ADE 22-16.936 2.431 21.119 1.00 0.00 H ATOM 13197 H3'ADE 22-15.636 6.259 20.640 1.00 0.00 H ATOM 13198 P CYT 23-13.822 4.629 19.217 1.00 0.00 P ATOM 13199 01P CYT 23-14.020 5.975 18.633 1.00 0.00 0 ATOM 13200 02P CYT 23-12.503 3.966 19.112 1.00 0.00 0 ATOM 13201 05'CYT 23-14.933 3.643 18.595 1.00 0.00 0 ATOM 13202 C5'CYT 23-14.947 2.255 18.940 1.00 0.00 C ATOM 13203 C4'CYT 23-16.136 1.530 18.318 1.00 0.00 C ATOM 13204 04'CYT 23-17.382 2.081 18.743 1.00 0.00 0 ATOM 13205 C1'CYT 23-18. 346 1.946 17.680 1.00 0.00 C ATOM 13206 N1 CYT 23-18.954 3.250 17.335 1.00 0.00 N ATOM 13207 C6 CYT 23-18.201 4.388 17.285 1.00 0.00 C ATOM 13208 C2 CYT 23-20.316 3.271 17.060 1.00 0.00 C ATOM 13209 02 CYT 23-20.974 2.233 17.112 1.00 0.00 0 ATOM 13210 N3 CYT 23-20.891 4.461 16.736 1.00 0.00 N ATOM 13211 C4 CYT 23-20.165 5.584 16.683 1.00 0.00 C ATOM 13212 N4 CYT 23-20.762 6.733 16.366 1.00 0.00 N ATOM 13213 C5 CYT 23-18.763 5.569 16.964 1.00 0.00 C ATOM 13214 C2'CYT 23-17.595 1.351 16.482 1.00 0.00 C ATOM 13215 02'CYT 23-17.797-0. 064 16.389 1.00 0.00 0 ATOM 13216 C3'CYT 23-16.152 1.688 16.812 1.00 0.00 C ATOM 13217 03'CYT 23-15.296 0.691 16.244 1.00 0.00 0 ATOM 13218 1H5'CYT 23-14.999 2.157 20.025 1.00 0.00 H ATOM 13219 2H5'CYT 23-14.025 1.793 18.586 1.00 0.00 H ATOM 13220 H4'CYT 23-16.101 0.472 18.577 1.00 0.00 H ATOM 13221 H1'CYT 23-19.130 1.254 17.991 1.00 0.00 H ATOM 13222 H6 CYT 23-17.135 4.341 17.511 1.00 0.00 H ATOM 13223 1H4 CYT 23-20.224 7.587 16.326 1.00 0.00 H ATOM 13224 2H4 CYT 23-21.751 6.750 16.167 1.00 0.00 H ATOM 13225 H5 CYT 23-18.169 6.480 16.913 1.00 0.00 H ATOM 13226 H2'CYT 23-17.900 1.852 15.559 1.00 0.00 H ATOM 13227 H02'CYT 23-17.187-0. 396 15.727 1.00 0.00 H ATOM 13228 H3'CYT 23-15.886 2.700 16.502 1.00 0.00 H ATOM 13229 P GUA 24-14.537 0.959 14.849 1.00 0.00 P ATOM 13230 01P GUA 24-14.427 2.422 14.651 1.00 0.00 0 ATOM 13231 02P GUA 24-13.320 0.118 14.816 1.00 0.00 0

ATOM 13232 05'GUA 24-15.580 0.382 13. 770 1. 00 0.00 0 ATOM 13233 C5'GUA 24-15.789-1. 027 13.641 1.00 0.00 C ATOM 13234 C4'GUA 24-16.665-1. 354 12.437 1.00 0.00 C ATOM 13235 04'GUA 24-17.962-0. 744 12.549 1.00 0.00 O ATOM 13236 C1'GUA 24-18.272-0. 054 11.327 1.00 0.00 C ATOM 13237 N9 GUA 24-18.122 1.405 11.480 1.00 0.00 N ATOM 13238 C4 GUA 24-18.513 2.359 10.575 1.00 0.00 C ATOM 13239 N3 GUA 24-19.117 2.120 9.391 1.00 0.00 N ATOM 13240 C2 GUA 24-19.379 3.243 8. 723 1.00 0.00 C ATOM 13241 N2 GUA 24-19.971 3.185 7.531 1.00 0.00 N ATOM 13242 N1 GUA 24-19.068 4.502 9.193 1.00 0. 00 N ATOM 13243 C6 GUA 24-18.448 4.774 10.405 1.00 0.00 C ATOM 13244 06 GUA 24-18.212 5.936 10.730 1.00 0.00 0 ATOM 13245 C5 GUA 24-18.165 3.583 11.123 1.00 0.00 C ATOM 13246 N7 GUA 24-17.557 3.409 12.370 1.00 0.00 N ATOM 13247 C8 GUA 24-17.576 2.124 12.493 1.00 0. 00 C ATOM 13248 C2'GUA 24-17.295-0. 598 10.297 1.00 0.00 C ATOM 13249 02'GUA 24-17.754-1. 833 9.734 1.00 0.00 0 ATOM 13250 C3'GUA 24-16.064-0. 794 11.155 1.00 0.00 C ATOM 13251 03'GUA 24-15.238-1. 798 10.557 1.00 0.00 0 ATOM 13252 1H5'GUA 24-16.271-1. 401 14.544 1.00 0.00 H ATOM 13253 2H5'GUA 24-14.824-1. 520 13.522 1.00 0.00 H ATOM 13254 H4'GUA 24-16.780-2. 433 12.348 1.00 0. 00 H ATOM 13255 H1'GUA 24-19.292-0. 283 11.019 1.00 0.00 H ATOM 13256 1H2 GUA 24-20.220 2.290 7.134 1.00 0.00 H ATOM 13257 2H2 GUA 24-20.171 4.034 7.025 1.00 0.00 H ATOM 13258 H1 GUA 24-19.302 5.301 8.629 1.00 0.00 H ATOM 13259 H8 GUA 24-17.173 1.635 13.381 1.00 0.00 H ATOM 13260 H2'GUA 24-17.107 0.147 9.519 1.00 0.00 H ATOM 13261 H02'GUA 24-17.933-2. 430 10.464 1.00 0.00 H ATOM 13262 H3'GUA 24-15.532 0.143 11.325 1.00 0.00 H ATOM 13263 P ADE 25-13.978-1. 382 9.641 1.00 0.00 P ATOM 13264 01P ADE 25-13.275-2. 618 9. 233 1.00 0.00 0 ATOM 13265 02P ADE 25-13.236-0. 306 10.335 1.00 0.00 0 ATOM 13266 05'ADE 25-14.684-0. 748 8.339 1.00 0.00 0 ATOM 13267 C5'ADE 25-15.476-1. 565 7.473 1.00 0.00 C ATOM 13268 C4'ADE 25-16.416-0. 729 6.608 1.00 0.00 C ATOM 13269 04'ADE 25-17.232 0.139 7.403 1.00 0.00 0 ATOM 13270 C1'ADE 25-17.342 1.421 6.755 1.00 0.00 C ATOM 13271 N9 ADE 25-16.669 2.481 7.535 1.00 0.00 N ATOM 13272 C4 ADE 25-16.749 3.837 7.314 1.00 0.00 C ATOM 13273 N3 ADE 25-17.448 4.446 6.337 1.00 0.00 N ATOM 13274 C2 ADE 25-17.319 5.766 6.401 1. 00 0.00 C ATOM 13275 N1 ADE 25-16. 608 6.466 7.287 1.00 0.00 N ATOM 13276 C6 ADE 25-15. 918 5.837 8.254 1.00 0.00 C ATOM 13277 N6 ADE 25-15.221 6.556 9.132 1.00 0.00 N ATOM 13278 C5 ADE 25-15.981 4.438 8.284 1.00 0.00 C ATOM 13279 N7 ADE 25-15.406 3.481 9.126 1.00 0.00 N ATOM 13280 C8 ADE 25-15.857 2.383 8.618 1.00 0.00 C ATOM 13281 C2'ADE 25-16.696 1.254 5.385 1.00 0.00 C ATOM 13282 02'ADE 25-17.643 0.803 4.409 1.00 0.00 0 ATOM 13283 C3'ADE 25-15.651 0.200 5.681 1.00 0.00 C ATOM 13284 03'ADE 25-15.348-0. 503 4.473 1.00 0.00 0 ATOM 13285 1H5'ADE 25-16.069-2. 252 8.077 1.00 0.00 H ATOM 13286 2H5'ADE 25-14.816-2. 142 6.825 1.00 0.00 H ATOM 13287 H4'ADE 25-17.057-1. 386 6.021 1.00 0.00 H ATOM 13288 Hl'ADE 25-18.395 1.673 6.629 1.00 0.00 H ATOM 13289 H2 ADE 25-17.853 6. 342 5.646 1.00 0.00 H ATOM 13290 1H6 ADE 25-14.702 6.094 9.866 1.00 0.00 H ATOM 13291 2H6 ADE 25-15.213 7.565 9. 065 1.00 0.00 H

ATOM 13292 H8 ADE 25-15.597 1.414 9.044 1.00 0.00 H ATOM 13293 H2'ADE 25-16.222 2.187 5.074 1.00 0.00 H ATOM 13294 H02'ADE 25-17.983-0. 043 4. 710 1.00 0.00 H ATOM 13295 H3'ADE 25-14. 766 0.627 6.156 1.00 0.00 H ATOM 13296 P CYT 26-14.274 0.091 3.430 1.00 0.00 P ATOM 13297 O1P CYT 26-14.063-0. 911 2.361 1.00 0.00 0 ATOM 13298 02P CYT 26-13.118 0.606 4.197 1.00 0.00 0 ATOM 13299 05'CYT 26-15.059 1.347 2.799 1.00 0.00 0 ATOM 13300 C5'CYT 26-16.134 1.145 1.877 1.00 0.00 C ATOM 13301 C4'CYT 26-16.722 2.471 1.402 1.00 0.00 C ATOM 13302 04'CYT 26-17.284 3.225 2.488 1.00 0.00 O ATOM 13303 C1'CYT 26-16.897 4.609 2.356 1.00 0.00 C ATOM 13304 N1. CYT 26-15.906 4.994 3.384 1.00 0.00 N ATOM 13305 C6 CYT 26-15.034 4. 077 3.892 1.00 0.00 C ATOM 13306 C2 CYT 26-15.877 6.323 3.790 1.00 0.00 C ATOM 13307 02 CYT 26-16.672 7.133 3. 317 1.00 0.00 O ATOM 13308 N3 CYT 26-14.950 6.695 4.715 1.00 0.00 N ATOM 13309 C4 CYT 26-14.088 5.803 5.219 1.00 0.00 C ATOM 13310 N4 CYT 26-13.195 6.196 6.128 1.00 0.00 N ATOM 13311 C5 CYT 26-14.115 4. 436 4.801 1.00 0.00 C ATOM 13312 C2'CYT 26-16.296 4.731 0.964 1.00 0.00 C ATOM 13313 02'CYT 26-17.303 4.949-0. 032 1.00 0.00 0 ATOM 13314 C3'CYT 26-15.646 3.373 0.822 1.00 0.00 C ATOM 13315 03'CYT 26-15.485 3.075-0. 568 1.00 0.00 0 ATOM 13316 1H5'CYT 26-16.917 0.562 2.362 1.00 0.00 H ATOM 13317 2H5'CYT 26-15.762 0.593 1.013 1.00 0.00 H ATOM 13318 H4'CYT 26-17. 491 2.287 0.654 1.00 0.00 H ATOM 13319 H1'CYT 26v-17. 778 5.246 2.435 1.00 0.00 H ATOM 13320 H6 CYT 26-15.086 3.039 3.563 1.00 0.00 H ATOM 13321 1H4 CYT 26-12.543 5.529 6.517 1.00 0.00 H ATOM 13322 2H4 CYT 26-13.171 7.159 6.428 1.00 0.00 H ATOM 13323 H5 CYT 26-13.404 3. 713 5.189 1.00 0.00 H ATOM 13324 H2'CYT 26-15.542 5.521 0.947 1.00 0.00 H ATOM 13325 H02'CYT 26-17.589 5.862 0.046 1.00 0.00 H ATOM 13326 H3'CYT 26-14.710 3.308 1.381 1.00 0.00 H ATOM 13327 P CYT 27-14. 059 3. 294-1. 286 1.00 0.00 P ATOM 13328 O1P CYT 27-14.193 2.910-2. 709 1.00 0. 00 0 ATOM 13329 02P CYT 27-13.016 2.663-0. 447 1.00 0.00 O ATOM 13330 05'CYT 27-13.869 4.891-1. 210 1.00 0.00 0 ATOM 13331 C5'CYT 27-14.805 5.764-1. 847 1.00 0.00 C ATOM 13332 C4'CYT 27-14.783 7.162-1. 234 1.00 0.00 C ATOM 13333 04'CYT 27-14. 936 7.123 0.185 1.00 0.00 0 ATOM 13334 C1'CYT 27-14.232 8.241 0.762 1.00 0.00 C ATOM 13335 N1 CYT 27-13.259 7.815 1.795 1.00 0.00 N ATOM 13336 C6 CYT 27-12.851 6.513 1.902 1.00 0.00 C ATOM 13337 C2 CYT 27-12. 774 8.796 2.648 1.00 0.00 C ATOM 13338 02 CYT 27-13.143 9.962 2.523 1.00 0.00 0 ATOM 13339 N3 CYT 27-11.878 8.437 3.604 1.00 0.00 N ATOM 13340 C4 CYT 27-11.470 7. 170 3.724 1.00 0.00 C ATOM 13341 N4 CYT 27-10.601 6.856 4.682 1.00 0.00 N ATOM 13342 C5 CYT 27-11. 959 6.150 2.849 1.00 0.00 C ATOM 13343 C2'CYT 27-13.519 8.946-0. 394 1.00 0.00 C ATOM 13344 02'CYT 27-14.272 10.072-0. 861 1.00 0.00 0 ATOM 13345 C3'CYT 27-13.448 7.848-1. 438 1.00 0.00 C ATOM 13346 03'CYT 27-13. 424 8.447-2. 739 1. 00 0. 00 0 ATOM 13347 1H5'CYT 27-15. 807 5.348-1. 742 1.00 0. OC H ATOM 13348 2H5'CYT 27-14. 560 5.836-2. 907 1.00 0.00 H ATOM 13349 H4'CYT 27-15.579 7.768-1. 666 1. 00 0.00 H ATOM 13350 Hl'CYT 27-14. 953 8.927 1.208 1.00 0.00 H ATOM 13351 H6 CYT 27-13.248 5. 763 1.218 1. 00 0.00 H

ATOM 13352 1H4 CYT 27-10.289 5. 902 4.791 1.00 0.00 H ATOM 13353 2H4 CYT 27-10.254 7.576 5.301 1.00 0.00 H ATOM 13354 H5 CYT 27-11.614 5.119 2.939 1.00 0.00 H ATOM 13355 H2'CYT 27-12.514 9.244-0. 090 1.00 0.00 H ATOM 13356 H02'CYT 27-14.213 10.753-0. 186 1.00 0. 00 H ATOM 13357 H3'CYT 27-12.607 7.173-1. 267 1.00 0.00 H ATOM 13358 P GUA 28-12.068 9.099-3. 318 1.00 0.00 P ATOM 13359 01P GUA 28-10.930 8.247-2. 905 1.00 0.00 0 ATOM 13360 02P GUA 28-12.277 9. 405-4. 751 1.00 0.00 0 ATOM 13361 05'GUA 28-11.969 10. 492-2. 514 1.00 0.00 O ATOM 13362 C5'GUA 28-12.844 11.581-2. 830 1. 0. 0 0.00 C ATOM 13363 C4'GUA 28-12.545 12.813-1. 978 1.00 0.00 C ATOM 13364 04'GUA 28-12.664 12.531-0. 579 1.00 0.00 0 ATOM 13365 C1'GUA 28-11.597 13.180 0.140 1.00 0.00 C ATOM 13366 N9 GUA 28-10.686 12.190 0.751 1.00 0.00 N ATOM 13367 C4 GUA 28-9. 852 12.391 1.831 1.00 0.00 C ATOM 13368 N3 GUA 28-9.695 13.552 2.509 1.00 0.00 N ATOM 13369 C2 GUA 28-8.816 13.437 3.512 1.00 0.00 C ATOM 13370 N2 GUA 28-8. 535 14.491 4.277 1.00 0.00 N ATOM 13371 N1 GUA 28-8.151 12. 265 3.817 1.00 0.00 N ATOM 13372 C6 GUA 28-8.296 11.063 3.137 1.00 0.00 C ATOM 13373 06 GUA 28-7.661 10.074 3.493 1.00 0.00 0 ATOM 13374 C5 GUA 28-9. 226 11.177 2.069 1.00 0.00 C ATOM 13375 N7 GUA 28-9.652 10.215 1.149 1.00 0.00 N ATOM 13376 C8 GUA 28-10.487 10.887 0.432 1.00 0.00 C ATOM 13377 C2'GUA 28-10.869 14.049-0. 880 1.00 0.00 C ATOM 13378 02'GUA 28-11.427 15.367-0. 940 1. 00 0.00 0 ATOM 13379 C3'GUA 28-11.111 13.280-2. 164 1.00 0.00 C ATOM 13380 03'GUA 28-11.066 14.196-3. 265 1.00 0.00 0 ATOM 13381 1H5'GUA 28-13.875 11.271-2. 655 1.00 0.00 H ATOM 13382 2H5'GUA 28-12. 724 11.839-3. 882 1.00 0.00 H ATOM 13383 H4'GUA 28-13.229 13.618-2. 243 1.00 0.00 H ATOM 13384 H1'GUA 28-12. 020 13.814 0.920 1.00 0.00 H ATOM 13385 1H2 GUA 28-8.986 15.378 4.100 1.00 0.00 H ATOM 13386 2H2 GUA 28-7.870 14.405 5.033 1.00 0.00 H ATOM 13387 H1 GUA 28-7.504 12.259 4.592 1.00 0.00 H ATOM 13388 H8 GUA 28-11.007 10.428-0. 408 1.00 0.00 H ATOM 13389 H2'GUA 28-9.803 14.084-0. 652 1.00 0. 00 H ATOM 13390 H02'GUA 28-11.133 15.763-1. 763 1.00 0.00 H ATOM 13391 H3'GUA 28-10. 417 12.446-2. 279 1.00 0.00 H ATOM 13392 P CYT 29-9.660 14.597-3. 944 1.00 0.00 P ATOM 13393 01P CYT 29-9.943 15.422-5. 140 1.00 0.00 0 ATOM 13394 02P CYT 29-8. 839 13.372-4. 071 1.00 0.00 O ATOM 13395 05'CYT 29-8.985 15.540-2. 826 1.00 0.00 O ATOM 13396 C5'CYT 29-9.281 16.940-2. 768 1.00 0.00 C ATOM 13397 C4'CYT 29-8.420 17.652-1. 728 1.00 0.00 C ATOM 13398 04'CYT 29-8.634 17. 120-0. 413 1.00 0.00 0 ATOM 13399 C1'CYT 29-7.368 16.907 0.239 1.00 0.00 C ATOM 13400 Nl CYT 29-7.075 15.462 0.380 1.00 0.00 N ATOM 13401 C6 CYT 29-7.466 14. 570-0. 577 1.00 0.00 C ATOM 13402 C2 CYT 29-6.409 15.046 1.526 1.00 0.00 C ATOM 13403 02 CYT 29-6.058 15.866 2.373 1.00 0.00 0 ATOM 13404 N3 CYT 29-6.156 13.716 1.678 1.00 0.00 N ATOM 13405 C4 CYT 29-6.537 12.832 0.748 1.00 0.00 C ATOM 13406 N4 CYT 29-6.277 11.538 0.929 1.00 0.00 N ATOM 13407 C5 CYT 29-7.220 13. 256-0. 434 1.00 0.00 C ATOM 13408 C2'CYT 29-6.329 17.606-0. 631 1.00 0.00 c ATOM 13409 02'CYT 29-6.185 18.985-0. 270 1.00 0.00 O ATOM 13410 C3'CYT 29-6.939 17.448-2. 010 1.00 0.00 c ATOM 13411 03'CYT 29-6.486 18. 520-2. 843 1.00 0.00 0

ATOM 13412 1H5'CYT 29-10.332 17.073-2. 511 1.00 0.00 H ATOM 13413 2H5'CYT 29-9.096 17.383-3. 747 1.00 0.00 H ATOM 13414 H4'CYT 29-8.649 18.716-1. 728 1.00 0.00 H ATOM 13415 H1'CYT 29-7.387 17.373 1.225 1.00 0.00 H ATOM 13416 H6 CYT 29-7.982 14.927-1. 468 1.00 0.00 H ATOM 13417 1H4 CYT 29-6.561 10.864 0.233 1.00 0.00 H ATOM 13418 2H4 CYT 29-5.793 11.232 1.760 1.00 0.00 H ATOM 13419 H5 CYT 29-7.531 12.538-1. 194 1.00 0.00 H ATOM 13420 H2'CYT 29-5.372 17.082-0. 573 1.00 0.00 H ATOM 13421 H02'CYT 29-7.064 19. 372-0. 267 1.00 0.00 H ATOM 13422 H3'CYT 29-6.732 16.466-2. 437 1.00 0.00 H ATOM 13423 P CYT 30-6.088 18.255-4. 382 1.00 0.00 P ATOM 13424 01P CYT 30-6.554 19.407-5. 186 1.00 0.00 0 ATOM 13425 02P CYT 30-6.513 16.883-4. 744 1.00 0.00 0 ATOM 13426 05'CYT 30-4.478 18.287-4. 338 1.00 0.00 0 ATOM 13427 C5'CYT 30-3.785 19.471-3. 926 1.00 0.00 C ATOM 13428 C4'CYT 30-2.827 19.189-2. 772 1.00 0.00 C ATOM 13429 04'CYT 30-3.494 18.555-1. 676 1.00 0.00 0 ATOM 13430 C1'CYT 30-2.620 17.572-1. 092 1.00 0.00 C ATOM 13431 N1 CYT 30-3.170 16.204-1. 233 1.00 0.00 N ATOM 13432 C6 CYT 30-3.885 15.841-2. 340 1.00 0.00 C ATOM 13433 C2 CYT 30-2.924 15.306-0. 204 1.00 0.00 C ATOM 13434 02 CYT 30-2.278 15.655 0.783 1.00 0.00 0 ATOM 13435 N3 CYT 30-3.414 14.042-0. 320 1.00 0.00 N ATOM 13436 C4 CYT 30-4.114 13.671-1. 399 1.00 0.00 C ATOM 13437 N4 CYT 30-4.572 12.421-1. 482 1.00 0.00 N ATOM 13438 C5 CYT 30-4.373 14.592-2. 462 1.00 0.00 C ATOM 13439 C2'CYT 30-1.287 17.709-1. 825 1.00 0.00 C ATOM 13440 02'CYT 30-0.425 18.648-1. 172 1.00 0.00 0 ATOM 13441 C3'CYT 30-1.736 18.215-3. 180 1.00 0.00 C ATOM 13442 03'CYT 30-0.673 18.866-3. 886 1.00 0.00 0 ATOM 13443 1H5'CYT 30-4.512 20.219-3. 608 1.00 0.00 H ATOM 13444 2H5'CYT 30-3.219 19.864-4. 771 1.00 0.00 H ATOM 13445 H4'CYT 30-2.378 20.120-2. 430 1.00 0.00 H ATOM 13446 H1'CYT 30-2.476 17.800-0. 035 1.00 0.00 H ATOM 13447 H6 CYT 30-4.064 16.569-3. 130 1.00 0.00 H ATOM 13448 1H4 CYT 30-5.098 12.129-2. 293 1.00 0.00 H ATOM 13449 2H4 CYT 30-4.387 11.766-0. 736 1.00 0.00 H ATOM 13450 H5 CYT 30-4.945 14.293-3. 340 1.00 0.00 H ATOM 13451 H2'CYT 30-0.805 16.732-1. 923 1.00 0.00 H ATOM 13452 H02'CYT 30-0.161 18.259-0. 335 1.00 0.00 H ATOM 13453 H3'CYT 30-2.159 17.394-3. 767 1.00 0.00 H ATOM 13454 H03'CYT 30-0.256 19.477-3. 273 1.00 0.00 H TER ATOM 13455 05'GUA 1-23.102-12. 821 1.939 1.00 0.00 0 ATOM 13456 C5'GUA 1-22.525-12. 972 0.639 1.00 0.00 C ATOM 13457 C4'GUA 1-23.279-12. 156-0.409 1.00 0.00 C ATOM 13458 04'GUA 1-24.663-12. 535-0.475 1.00 0.00 0 ATOM 13459 C1'GUA 1-25.486-11. 355-0.447 1.00 0.00 C ATOM 13460 N9 GUA 1-26.127-11. 181 0.872 1.00 0.00 N ATOM 13461 C4 GUA 1-27.230-10. 406 1.155 1.00 0.00 C ATOM 13462 N3 GUA 1-27.925-9. 661 0.266 1.00 0.00 N ATOM 13463 C2 GUA 1-28.947-9. 017 0. 838 1.00 0.00 C ATOM 13464 N2 GUA 1-29.735-8. 232 0.104 1.00 0.00 N ATOM 13465 N1 GUA 1-29.253-9. 106 2.181 1.00 0.00 N ATOM 13466 C6 GUA 1-28.555-9. 863 3.113 1.00 0.00 C ATOM 13467 06 GUA 1-28.909-9. 872 4.290 1.00 0.00 0 ATOM 13468 C5 GUA 1-27.467-10. 551 2.514 1.00 0.00 C ATOM 13469 N7 GUA 1-26.526-11. 408 3.090 1.00 0.00 N ATOM 13470 C8 GUA 1-25.797-11. 720 2.072 1.00 0.00 C

ATOM 13471 C2'GUA 1-24.544-10. 202-0.753 1.00 0.00 C ATOM 13472 02'GUA 1-24.342-10. 048-2.163 1.00 0. 00 O ATOM 13473 C3'GUA 1-23.287-10. 675-0.056 1.00 0.00 C ATOM 13474 03'GUA 1-22. 157-10.046-0. 668 1.00 0.00 0 ATOM 13475 H5'GUA 1-22.583-13. 355 2.545 1.00 0.00 H ATOM 13476 1H5'GUA 1-22.553-14. 024 0.358 1.00 0.00 H ATOM 13477 2H5'GUA 1-21.487-12. 639 0.670 1.00 0.00 H ATOM 13478 H4'GUA 1-22.819-12. 298-1.386 1.00 0.00 H ATOM 13479 H1'GUA 1-26.250-11. 421-1.222 1.00 0.00 H ATOM 13480 1H2 GUA 1-29.559-8. 124-0.885 1.00 0.00 H ATOM 13481 2H2 GUA 1-30.507-7. 745 0.536 1.00 0.00 H ATOM 13482 H1 GUA 1-30.042-8. 588 2.536 1.00 0.00 H ATOM 13483 H8 GUA 1-24.943-12. 389 2.174 1.00 0.00 H ATOM 13484 H2'GUA 1-24.912-9. 277-0.300 1.00 0.00 H ATOM 13485 H02'GUA 1-23.439-9. 750-2.291 1.00 0.00 H ATOM 13486 H3'GUA 1-23. 330-10.508 1.022 1.00 0.00 H ATOM 13487 P GUA 2-21. 576-8. 663-0.082 1.00 0.00 P ATOM 13488 O1P GUA 2-20.440-8. 241-0.932 1.00 0.00 0 ATOM 13489 02P GUA 2-21.386-8. 821 1.377 1.00 0.00 0 ATOM 13490 05'GUA 2-22. 795-7.639-0. 324 1.00 0.00 0 ATOM 13491 C5'GUA 2-23.118-7. 192-1.644 1.00 0.00 C ATOM 13492 C4'GUA 2-24.435-6. 421-1.674 1.00 0.00 C ATOM 13493 04'GUA 2-25.524-7. 204-1.173 1.00 0.00 0 ATOM 13494 Cl'GUA 2-26.431-6. 346-0.450 1.00 0.00 C ATOM 13495 N9 GUA 2-26.535-6. 740 0.970 1.00 0.00 N ATOM 13496 C4 GUA 2-27.530-6. 372 1. 848 1.00 0.00 C ATOM 13497 N3 GUA 2-28.597-5. 595 1.555 1.00 0.00 N ATOM 13498 C2 GUA 2-29.392-5. 409 2.612 1.00 0.00 C ATOM 13499 N2 GUA 2-30.491-4. 663 2.496 1.00 0.00 N ATOM 13500 N1 GUA 2-29.148-5. 952 3.858 1.00 0.00 N ATOM 13501 C6 GUA 2-28.061-6. 752 4.183 1.00 0.00 C ATOM 13502 06 GUA 2-27. 935-7.187 5.325 1.00 0.00 0 ATOM 13503 C5 GUA 2-27.209-6. 954 3.064 1.00 0.00 C ATOM 13504 N7 GUA 2-26.023-7. 687 2.962 1.00 0.00 N ATOM 13505 C8 GUA 2-25.708-7. 507 1.723 1.00 0.00 C ATOM 13506 C2'GUA 2-25.869-4. 931-0.578 1.00 0.00 C ATOM 13507 02'GUA 2-26.423-4. 246-1.708 1.00 0. 00 O ATOM 13508 C3'GUA 2-24.392-5. 212-0.761 1.00 0.00 C ATOM 13509 03'GUA 2-23.795-4. 119-1.465 1.00 0.00 0 ATOM 13510 1H5'GUA 2-23.197-8. 055-2.304 1.00 0.00 H ATOM 13511 2H5'GUA 2-22.319-6. 543-2. 003 1.00 0.00 H ATOM 13512 H4'GUA 2-24.655-6. 106-2.692 1.00 0.00 H ATOM 13513 H1'GUA 2-27.417-6. 388-0.913 1.00 0.00 H ATOM 13514 1H2 GUA 2-30.721-4. 239 1.609 1.00 0.00 H ATOM 13515 2H2 GUA 2-31.091-4. 520 3.296 1.00 0.00 H ATOM 13516 H1 GUA 2-29.799-5. 764 4.608 1.00 0.00 H ATOM 13517 H8 GUA 2-24.810-7. 957 1.299 1.00 0.00 H ATOM 13518 H2'GUA 2-26.040-4. 371 0.344 1.00 0.00 H ATOM 13519 H02'GUA 2-27. 330-4.021-1. 489 1.00 0.00 H ATOM 13520 H3'GUA 2-23.896-5. 428 0. 187 1.00 0.00 H ATOM 13521 P CYT 3-23.207-2. 855-0.658 1.00 0.00 P ATOM 13522 01P CYT 3-22.659-1. 893-1.640 1.00 0.00 O ATOM 13523 02P CYT 3-22. 350-3.361 0.437 1.00 0.00 0 ATOM 13524 05'CYT 3-24.531-2. 211-0.004 1.00 0.00 0 ATOM 13525 C5'CYT 3-25.466-1. 495-0.816 1.00 0.00 C ATOM 13526 C4'CYT 3-26.731-1. 133-0.041 1. 00 0.00 C ATOM 13527 04'CYT 3-27.406-2. 295 0.461 1.00 0.00 0 ATOM 13528 C1'CYT 3-27.897-2. 017 1.790 1.00 0.00 C ATOM 13529 N1 CYT 3-27.170-2. 798 2.814 1.00 0.00 N

ATOM 13530 C6 CYT 3-25.876-3. 180 2.616 1.00 0.00 C ATOM 13531 C2 CYT 3-27.844-3. 103 3.988 1.00 0.00 C ATOM 13532 02 CYT 3-29.007-2. 740 4.146 1.00 0.00 0 ATOM 13533 N3 CYT 3-27.181-3. 799 4.951 1.00 0.00 N ATOM 13534 C4 CYT 3-25.910-4. 181 4.770 1.00 0.00 C ATOM 13535 N4 CYT 3-25.293-4. 867 5.732 1.00 0.00 N ATOM 13536 C5 CYT 3-25.212-3. 866 3.561 1.00 0.00 C ATOM 13537 C2'CYT 3-27.677-0. 527 2.004 1.00 0.00 C ATOM 13538 02'CYT 3-28.769 0.248 1.493 1.00 0.00 0 ATOM 13539 C3'CYT 3-26.414-0. 317 1.199 1.00 0.00 C ATOM 13540 03'CYT 3-26.315 1.064 0.840 1.00 0.00 0 ATOM 13541 1H5'CYT 3-25.739-2. 113-1.672 1.00 0.00 H ATOM 13542 2H5'CYT 3-24.995-0. 579-1.174 1.00 0.00 H ATOM 13543 H4'CYT 3-27.408-0. 574-0.685 1.00 0.00 H ATOM 13544 H1'CYT 3-28.963-2. 243 1.842 1.00 0.00 H ATOM 13545 H6 CYT 3-25.374-2. 925 1.683 1.00 0.00 H ATOM 13546 1H4 CYT 3-24.336-5. 164 5.606 1.00 0.00 H ATOM 13547 2H4 CYT 3-25.781-5. 085 6.590 1.00 0.00 H ATOM 13548 H5 CYT 3-24.175-4. 158 3.414 1.00 0.00 H ATOM 13549 H2'CYT 3-27.499-0. 316 3.060 1.00 0.00 H ATOM 13550 H02'CYT 3-28.885 0.005 0.572 1.00 0.00 H ATOM 13551 H3'CYT 3-25.528-0. 689 1.723 1.00 0.00 H ATOM 13552 P GUA 4-25.726 2.139 1.886 1.00 0.00 P ATOM 13553 01P GUA 4-25.592 3.438 1.190 1.00 0.00 0 ATOM 13554 02P GUA 4-24.552 1.538 2.558 1.00 0.00 O ATOM 13555 05'GUA 4-26.913 2.266 2.968 1.00 0.00 O ATOM 13556 C5'GUA 4-28.156 2.884 2.618 1.00 0.00 C ATOM 13557 C4'GUA 4-29.115 2.933 3.804 1.00 0.00 C ATOM 13558 04'GUA 4-29.408 1.624 4.303 1.00 0.00 O ATOM 13559 Cl'GUA 4-29.466 1.656 5.742 1.00 0.00 C ATOM 13560 N9 GUA 4-28.408 0.813 6.337 1.00 0.00 N ATOM 13561 C4 GUA 4-28.374 0.325 7.625 1.00 0.00 C ATOM 13562 N3 GUA 4-29.295 0.560 8.588 1. 00 0.00 N ATOM 13563 C2 GUA 4-28.990-0. 049 9.738 1.00 0.00 C ATOM 13564 N2 GUA 4-29. 789 0.087 10.795 1.00 0.00 N ATOM 13565 Nl GUA 4-27.864-0. 829 9.917 1.00 0.00 N ATOM 13566 C6 GUA 4-26.906-1. 085 8.945 1.00 0.00 C ATOM 13567 06 GUA 4-25.943-1. 803 9.203 1.00 0.00 O ATOM 13568 C5 GUA 4-27.221-0. 439 7.720 1.00 0.00 C ATOM 13569 N7 GUA 4-26.527-0. 436 6.506 1.00 0.00 N ATOM 13570 C8 GUA 4-27.283 0.309 5.773 1.00 0.00 C ATOM 13571 C2'GUA 4-29.299 3.120 6.144 1.00 0.00 C ATOM 13572 02'GUA 4-30.568 3.775 6.272 1.00 0.00 0 ATOM 13573 C3'GUA 4-28.499 3.670 4.980 1.00 0.00 C ATOM 13574 03'GUA 4-28.784 5.066 4.840 1.00 0.00 O ATOM 13575 1H5'GUA 4-28.619 2.318 1.810 1.00 0.00 H ATOM 13576 2H5'GUA 4-27.962 3.900 2.275 1.00 0.00 H ATOM 13577 H4'GUA 4-30.041 3.423 3.509 1.00 0.00 H ATOM 13578 H1'GUA 4-30.442 1.300 6.073 1.00 0.00 H ATOM 13579 1H2 GUA 4-30.625 0.650 10.727 1.00 0.00 H ATOM 13580 2H2 GUA 4-29. 558-0.369 11.666 1.00 0.00 H ATOM 13581 H1 GUA 4-27.705-1. 258 10.817 1.00 0.00 H ATOM 13582 H8 GUA 4-27.021 0.534 4.740 1.00 0.00 H ATOM 13583 H2'GUA 4-28.724 3.194 7.070 1.00 0. 00 H ATOM 13584 H02'GUA 4-30.990 3.428 7.061 1.00 0.00 H ATOM 13585 H3'GUA 4-27.433 3.465 5.083 1.00 0.00 H ATOM 13586 P CYT 5-27.976 6.159 5.705 1.00 0.00 P ATOM 13587 O1P CYT 5-26.539 5.805 5.675 1. 00 0.00 O ATOM 13588 02P CYT 5-28.412 7.506 5.272 1.00 0. 00 O ATOM 13589 05'CYT 5-28.526 5.903 7.196 1.00 0.00 O

ATOM 13590 C5'CYT 5-29.842 6.322 7.572 1.00 0.00 C ATOM 13591 C4'CYT 5-30.136 5.993 9.033 1.00 0.00 C ATOM 13592 04'CYT 5-30.105 4.579 9.272 1.00 0.00 0 ATOM 13593 C1'CYT 5-29.349 4.304 10.466 1.00 0.00 C ATOM 13594 N1 CYT 5-28.063 3.644 10.142 1.00 0.00 N ATOM 13595 C6 CYT 5-27.347 4.003 9.036 1.00 0.00 C ATOM 13596 C2 CYT 5-27.623 2.635 10.991 1.00 0.00 C ATOM 13597 02 CYT 5-28.280 2.330 11.985 1.00 0.00 O ATOM 13598 N3 CYT 5-26.454 2.004 10.691 1.00 0.00 N ATOM 13599 C4 CYT 5-25.745 2.347 9.608 1.00 0.00 C ATOM 13600 N4 CYT 5-24.609 1.704 9.338 1.00 0.00 N ATOM 13601 C5 CYT 5-26.192 3.386 8.734 1.00 0.00 C ATOM 13602 C2'CYT 5-29.132 5.653 11. 143 1.00 0.00 C ATOM 13603 02'CYT 5-30.218 5.984 12.017 1.00 0.00 O ATOM 13604 C3'CYT 5-29.072 6.582 9.946 1.00 0.00 C ATOM 13605 03'CYT 5-29.495 7.889 10.347 1.00 0.00 O ATOM 13606 1H5'CYT 5-30.573 5.817 6.939 1.00 0.00 H ATOM 13607 2H5'CYT 5-29.928 7.399 7.425 1.00 0.00 H ATOM 13608 H4'CYT 5-31.114 6.385 9.308 1.00 0.00 H ATOM 13609 H1'CYT 5-29.933 3.661 11.124 1.00 0.00 H ATOM 13610 H6 CYT 5-27.717 4.798 8.389 1.00 0.00 H ATOM 13611 1H4 CYT. 5-24.287 0.969 9.951 1.00 0.00 H ATOM 13612 2H4 CYT 5-24.070 1.954 8.521 1.00 0.00 H ATOM 13613 H5 CYT 5-25.615 3.670 7.855 1.00 0.00 H ATOM 13614 H2'CYT 5-28.181 5.658 11.678 1.00 0.00 H ATOM 13615 H02'CYT 5-30.158 5.404 12.779 1.00 0.00 H ATOM 13616 H3'CYT 5-28.086 6. 584 9.481 1.00 0.00 H ATOM 13617 P URI 6-28.439 9.102 10.428 1.00 0.00 P ATOM 13618 01P URI 6-29.194 10.375 10.420 1.00 0.00 0 ATOM 13619 02P URI 6-27. 381 8.865 9.420 1.00 0.00 0 ATOM 13620 05'URI 6-27.794 8.904 11.889 1.00 0.00 O ATOM 13621 C5'URI 6-28.573 9.144 13. 065 1.00 0.00 C ATOM 13622 C4'URI 6-28.056 8.343 14.255 1.00 0.00 C ATOM 13623 04'URI 6-28.054 6.933 13.985 1.00 0.00 O ATOM 13624 C1'URI 6-26.834 6.352 14.489 1.00 0.00 C ATOM 13625 N1 URI 6-25.944 5.914 13.389 1.00 0.00 N ATOM 13626 C6 URI 6-25.964 6. 538 12.169 1.00 0.00 C ATOM 13627 C2 URI 6-25.086 4.858 13.643 1.00 0.00 C ATOM 13628 02 URI 6-25.050 4.287 14.732 1.00 0.00 0 ATOM 13629 N3 URI 6-24.264 4.480 12.599 1.00 0.00 N ATOM 13630 C4 URI 6-24.220 5.054 11.342 1.00 0.00 C ATOM 13631 04 URI 6-23.444 4.633 10.488 1.00 0.00 0 ATOM 13632 C5 URI 6-25.146 6.148 11.163 1.00 0.00 C ATOM 13633 C2'URI 6-26.175 7.442 15.321 1.00 0.00 C ATOM 13634 02'URI 6-26.664 7.445 16.668 1.00 0.00 O ATOM 13635 C3'URI 6-26.607 8.679 14.564 1.00 0.00 C ATOM 13636 03'URI 6-26.566 9.803 15.449 1.00 0.00 0 ATOM 13637 1H5'URI 6-29.608 8.862 12.871 1.00 0.00 H ATOM 13638 2H5'URI 6-28.533 10.206 13.306 1.00 0.00 H ATOM 13639 H4'URI 6-28.674 8.541 15.129 1.00 0.00 H ATOM 13640 H1'URI 6-27.072 5.502 15.128 1.00 0.00 H ATOM 13641 H6 URI 6-26.655 7.364 12.005 1.00 0.00 H ATOM 13642 H3 URI 6-23.634 3.712 12.771 1.00 0.00 H ATOM 13643 H5 URI 6-25.185 6.668 10.205 1.00 0.00 H ATOM 13644 H2'URI 6-25.090 7.335 15.295 1.00 0.00 H ATOM 13645 H02'URI 6-26.232 6.722 17.129 1.00 0.00 H ATOM 13646 H3'URI 6-26.017 8.831 13.659 1.00 0.00 H ATOM 13647 P CYT 7-25.225 10.687 15.580 1.00 0.00 P ATOM 13648 01P CYT 7-24.722 10.972 14.217 1.00 0.00 O ATOM 13649 02P CYT 7-25.494 11. 802 16.515 1.00 0.00 O

ATOM 13650 05'CYT 7-24.200 9.668 16. 290 1.00 0. 00 0 ATOM 13651 C5'CYT 7-24.412 9.250 17.641 1.00 0.00 C ATOM 13652 C4'CYT 7-23.615 7.992 17.975 1.00 0.00 C ATOM 13653 04'CYT 7-23.900 6.925 17.061 1.00 0.00 0 ATOM 13654 C1'CYT 7-22.685 6.200 16.779 1.00 0.00 C ATOM 13655 N1 CYT 7-22.286 6.324 15.358 1.00 0.00 N ATOM 13656 C6 CYT 7-22.719 7.367 14.589 1.00 0.00 C ATOM 13657 C2 CYT 7-21.444 5.345 14.841 1.00 0.00 C ATOM 13658 02 CYT 7-21.060 4.418 15.552 1.00 0.00 0 ATOM 13659 N3 CYT 7-21.057 5.448 13.542 1.00 0.00 N ATOM 13660 C4 CYT 7-21.474 6.465 12.778 1.00 0.00 C ATOM 13661 N4 CYT 7-21.072 6.534 11.511 1.00 0.00 N ATOM 13662 C5 CYT 7-22.340 7.475 13.302 1.00 0.00 C ATOM 13663 C2'CYT 7-21.622 6.800 17.692 1.00 0.00 C ATOM 13664 02'CYT 7-21.575 6.126 18.956 1.00 0.00 0 ATOM 13665 C3'CYT 7-22.122 8.221 17.834 1.00 0.00 C ATOM 13666 03'CYT 7-21.614 8.768 19.056 1.00 0.00 0 ATOM 13667 1H5'CYT 7-25.473 9.047 17.789 1.00 0.00 H ATOM 13668 2H5'CYT 7-24.106 10.053 18.314 1.00 0.00 H ATOM 13669 H4'CYT 7-23.843 7.668 18.989 1.00 0.00 H ATOM 13670 H1'CYT 7-22.825 5.147 17.028 1.00 0.00 H ATOM 13671 H6 CYT 7-23.378 8.119 15.021 1.00 0.00 H ATOM 13672 1H4 CYT 7-21.377 7.297 10.924 1.00 0.00 H ATOM 13673 2H4 CYT 7-20.460 5.822 11.138 1.00 0.00 H ATOM 13674 H5 CYT 7-22.681 8.303 12.681 1.00 0.00 H ATOM 13675 H2'CYT 7-20.646 6.784 17.200 1.00 0.00 H ATOM 13676 H02'CYT 7-22.469 6.116 19.308 1.00 0.00 H ATOM 13677 H3'CYT 7-21.877 8. 831 16.962 1.00 0.00 H ATOM 13678 P ADE 8-20.200 9.543 19.079 1.00 0.00 P ATOM 13679 O1P ADE 8-20.264 10.653 18.102 1.00 0.00 O ATOM 13680 02P ADE 8-19.848 9.822 20.489 1.00 0.00 O ATOM 13681 05'ADE 8-19.176 8.433 18.513 1.00 0.00 O ATOM 13682 C5'ADE 8-18.901 7.244 19.261 1.00 0.00 C ATOM 13683 C4'ADE 8-18.260 6.163 18.391 1.00 0.00 C ATOM 13684 04'ADE 8-19.064 5.867 17.236 1.00 0.00 O ATOM 13685 C1'ADE 8-18.221 5.803 16.070 1.00 0.00 C ATOM 13686 N9 ADE 8-18.406 6.986 15.202 1.00 0.00 N ATOM 13687 C4 ADE 8-18.045 7.102 13.875 1.00 0.00 C ATOM 13688 N3 ADE 8-17.460 6.152 13.114 1.00 0. 00 N ATOM 13689 C2 ADE 8-17.244 6.589 11.874 1.00 0.00 C ATOM 13690 N1 ADE 8-17.540 7.792 11.382 1.00 0.00 N ATOM 13691 C6 ADE 8-18.122 8.722 12.159 1.00 0.00 C ATOM 13692 N6 ADE 8-18.408 9.918 11.646 1.00 0.00 N ATOM 13693 C5 ADE 8-18.398 8.373 13.486 1.00 0.00 C ATOM 13694 N7 ADE 8-18.982 9.074 14.545 1.00 0. 00 N ATOM 13695 C8 ADE 8-18.944 8.197 15.491 1.00 0.00 C ATOM 13696 C2'ADE 8-16.802 5.734 16.604 1.00 0.00 C ATOM 13697 02'ADE 8-16.433 4.394 16.954 1.00 0.00 0 ATOM 13698 C3'ADE 8-16.925 6.619 17.825 1.00 0.00 C ATOM 13699 03'ADE 8-15.884 6.285 18.749 1.00 0.00 0 ATOM 13700 1H5'ADE 8-19.834 6.859 19.673 1.00 0.00 H ATOM 13701 2H5'ADE 8-18.225 7.488 20.080 1.00 0.00 H ATOM 13702 H4'ADE 8-18.121 5.255 18.975 1.00 0.00 H ATOM 13703 Hl'ADE 8-18.442 4.900 15.508 1.00 0.00 H ATOM 13704 H2 ADE 8-16.772 5.887 11.184 1.00 0. 00 H ATOM 13705 1H6 ADE 8-18.188 10. 120 10.682 1.00 0.00 H ATOM 13706 2H6 ADE 8-18.843 10.624 12.223 1.00 0.00 H ATOM 13707 H8 ADE 8-19.329 8. 421 16.485 1.00 0. 00 H ATOM 13708 H2'ADE 8-16.105 6. 162 15.882 1.00 0.00 H ATOM 13709 H02'ADE 8-15.635 4.448 17.486 1.00 0.00 H

ATOM 13710 H3'ADE 8-16.931 7.676 17.561 1.00 0.00 H ATOM 13711 P ADE 9-15.329 7.384 19.790 1.00 0.00 P ATOM 13712 O1P ADE 9-13. 986 6.956 20.241 1.00 0.00 0 ATOM 13713 02P ADE 9-16.389 7.658 20.786 1.00 0.00 0 ATOM 13714 05'ADE 9-15.158 8.691 18.863 1.00 0.00 0 ATOM 13715 C5'ADE 9-14. 552 9.881 19.380 1.00 0.00 C ATOM 13716 C4'ADE 9-14.447 10.972 18.313 1.00 0.00 C ATOM 13717 04'ADE 9-13.769 10.495 17.148 1.00 0.00 0 ATOM 13718 C1'ADE 9-14.712 10.281 16.085 1.00 0.00 C ATOM 13719 N9 ADE 9-14.531 8.949 15.482 1.00 0.00 N ATOM 13720 C4 ADE 9-14.397 8.666 14.145 1.00 0.00 C ATOM 13721 N3 ADE 9-14.417 9.557 13.139 1.00 0.00 N ATOM 13722 C2 ADE 9-14.259 8.961 11.965 1.00 0.00 C ATOM 13723 N1 ADE 9-14.099 7.657 11.735 1.00 0.00 N ATOM 13724 C6 ADE 9-14.083 6.785 12.757 1.00 0.00 C ATOM 13725 N6 ADE 9-13.922 5.485 12.508 1.00 0.00 N ATOM 13726 C5 ADE 9-14.239 7.304 14.046 1.00 0.00 C ATOM 13727 N7 ADE 9-14.271 6.708 15.310 1.00 0.00 N ATOM 13728 C8 ADE 9-14.443 7.733 16.074 1.00 0.00 C ATOM 13729 C2'ADE 9-16.095 10.419 16.712 1.00 0.00 C ATOM 13730 02'ADE 9-17.054 10.925 15.775 1.00 0.00 0 ATOM 13731 C3'ADE 9-15. 822 11.410 17. 823 1.00 0.00 C ATOM 13732 03'ADE 9-15.712 12.711 17.232 1.00 0.00 0 ATOM 13733 1H5'ADE 9-13.552 9.642 19.741 1.00 0.00 H ATOM 13734 2H5'ADE 9-15.151 10.253 20.211 1.00 0.00 H ATOM 13735 H4'ADE 9-13.910 11. 827 18.717 1.00 0.00 H ATOM 13736 H1'ADE 9-14.581 11.048 15.322 1.00 0.00 H ATOM 13737 H2 ADE 9-14.246 9.611 11.096 1.00 0.00 H ATOM 13738 1H6 ADE 9-13.909 4.823 13.270 1.00 0.00 H ATOM 13739 2H6 ADE 9-13.813 5.163 11.557 1.00 0.00 H ATOM 13740 H8 ADE 9-14.525 7.624 17.155 1.00 0.00 H ATOM 13741 H2'ADE 9-16.418 9.467 17.133 1.00 0.00 H ATOM 13742 H02'ADE 9-16.732 11.777 15.470 1.00 0.00 H ATOM 13743 H3'ADE 9-16.573 11.369 18.609 1.00 0.00 H ATOM 13744 P URI 10-15.363 14.018 18.108 1.00 0.00 P ATOM 13745 01P URI 10-14.460 13.623 19.213 1.00 0.00 0 ATOM 13746 02P URI 10-16.627 14.729 18.405 1.00 0.00 0 ATOM 13747 05'URI 10-14.524 14.900 17.054 1.00 0.00 0 ATOM 13748 C5'URI 10-13.190 15.334 17.339 1.00 0.00 C ATOM 13749 C4'URI 10-12. 193 14.789 16.313 1.00 0.00 C ATOM 13750 04'URI 10-12.727 14.814 14.988 1.00 0.00 O ATOM 13751 C1'URI 10-12.289 16.010 14.314 1.00 0.00 C ATOM 13752 N1 URI 10-13.448 16.828 13.897 1. 00 0.00 N ATOM 13753 C6 URI 10-14.711 16.524 14.331 1.00 0.00 C ATOM 13754 C2 URI 10-13.212 17.904 13.058 1.00 0.00 C ATOM 13755 02 URI 10-12. 087 18.189 12.653 1.00 0.00 0 ATOM 13756 N3 URI 10-14.323 18.643 12.693 1.00 0.00 N ATOM 13757 C4 URI 10-15. 629 18.404 13.087 1.00 0.00 C ATOM 13758 04 URI 10-16.541 19.130 12.700 1.00 0.00 0 ATOM 13759 C5 URI 10-15.781 17.263 13.960 1.00 0.00 C ATOM 13760 C2'URI 10-11.405 16.767 15.310 1.00 0.00 C ATOM 13761 02'URI 10-10.295 17.396 14.660 1.00 0.00 0 ATOM 13762 C3'URI 10-10.952 15.654 16.240 1.00 0.00 C ATOM 13763 03'URI 10-9.914 14.909 15.587 1.00 0.00 0 ATOM 13764 1H5'URI 10-12.902 14.992 18.333 1.00 0.00 H ATOM 13765 2H5'URI 10-13.163 16.424 17.317 1.00 0.00 H ATOM 13766 H4'URI 10-11. 919 13.768 16.573 1.00 0.00 H ATOM 13767 H1'URI 10-11.700 15.741 13.436 1.00 0.00 H ATOM 13768 H6 URI 10-14.858 15. 666 14.986 1.00 0.00 H ATOM 13769 H3 URI 10-14.167 19.431 12. 082 1.00 0.00 H

ATOM 13770 H5 URI 10-16.770 16.992 14.327 1.00 0.00 H ATOM 13771 H2'URI 10-12.005 17.496 15.863 1.00 0.00 H ATOM 13772 H02'URI 10-9.808 16.709 14. 200 1.00 0.00 H ATOM 13773 H3'URI 10-10.648 16.028 17.219 1.00 0.00 H ATOM 13774 P GUA 11-8.919 13.962 16.431 1.00 0.00 P ATOM 13775 01P GUA 11-8.786 14.526 17.794 1.00 0.00 0 ATOM 13776 02P GUA 11-7.710 13.721 15.614 1.00 0.00 O ATOM 13777 05'GUA 11-9.739 12.578 16.534 1.00 0.00 0 ATOM 13778 C5'GUA 11-9.550 11.702 17.650 1.00 0.00 C ATOM 13779 C4'GUA 11-9.919 10. 258 17.312 1.00 0.00 C ATOM 13780 04'GUA 11-11.252 10.163 16.787 1.00 0.00 0 ATOM 13781 Cl'GUA 11-11.240 9.350 15.598 1.00 0.00 C ATOM 13782 N9 GUA 11-11.344 10.179 14. 384 1.00 0.00 N ATOM 13783 C4 GUA 11-11.338 9.730 13.085 1.00 0.00 C ATOM 13784 N3 GUA 11-11. 212 8.442 12.695 1.00 0.00 N ATOM 13785 C2 GUA 11-11. 242 8.314 11.367 1.00 0.00 C ATOM 13786 N2 GUA 11-11.130 7.107 10.813 1.00 0.00 N ATOM 13787 N1 GUA 11-11. 385 9.376 10.499 1.00 0.00 N ATOM 13788 C6 GUA 11-11. 516 10. 706 10.874 1.00 0.00 C ATOM 13789 06 GUA 11-11.640 11.580 10.019 1.00 0.00 0 ATOM 13790 C5 GUA 11-11.485 10.853 12.286 1.00 0.00 C ATOM 13791 N7 GUA 11-11.581 12.006 13.071 1.00 0.00 N ATOM 13792 C8 GUA 11-11.489 11.519 14.262 1.00 0.00 C ATOM 13793 C2'GUA 11-9.913 8.610 15.641 1.00 0.00 C ATOM 13794 02'GUA 11-9. 977 7.460 16.494 1.00 0.00 0 ATOM 13795 C3'GUA 11-9. 024 9.692 16.218 1.00 0.00 C ATOM 13796 03'GUA 11-7. 880 9. 082 16.823 1.00 0.00 O ATOM 13797 1H5'GUA 11-10. 174 12.042 18.476 1.00 0.00 H ATOM 13798 2H5'GUA 11-8. 504 11.737 17.959 1.00 0.00 H ATOM 13799 H4'GUA 11-9. 840 9.641 18.206 1.00 0.00 H ATOM 13800 H1'GUA 11-12. 067 8.639 15.627 1.00 0.00 H ATOM 13801 1H2 GUA 11-11.153 7.008 9.808 1.00 0.00 H ATOM 13802 2H2 GUA 11-11.024 6.291 11.398 1.00 0.00 H ATOM 13803 H1 GUA 11-11.396 9.195 9.506 1.00 0.00 H ATOM 13804 H8 GUA 11-11.514 12.161 15.139 1.00 0.00 H ATOM 13805 H2'GUA 11-9. 591 8.340 14.631 1.00 0.00 H ATOM 13806 H02'GUA 11-10.332 7.750 17.338 1.00 0.00 H ATOM 13807 H3'GUA 11-8.760 10.443 15.472 1.00 0.00 H ATOM 13808 P CYT 12-6.427 9.227 16.143 1.00 0.00 P ATOM 13809 01P CYT 12-5. 437 8.556 17.016 1.00 0.00 0 ATOM 13810 02P CYT 12-6.234 10.644 15.761 1.00 0.00 0 ATOM 13811 05'CYT 12-6.582 8.359 14.796 1.00 0.00 0 ATOM 13812 C5'CYT 12-6.637 6.931 14.856 1.00 0.00 C ATOM 13813 C4'CYT 12-6.846 6.316 13.475 1.00 0.00 C ATOM 13814 04'CYT 12-8.067 6.759 12. 875 1.00 0.00 0 ATOM 13815 C1'CYT 12-7.863 6.956 11.461 1.00 0.00 C ATOM 13816 N1 CYT 12-8.064 8.374 11.077 1.00 0.00 N ATOM 13817 C6 CYT 12-8.163 9.355 12.024 1.00 0.00 C ATOM 13818 C2 CYT 12-8.188 8.661 9.723 1.00 0.00 C ATOM 13819 02 CYT 12-8.065 7.770 8.885 1.00 0.00 O ATOM 13820 N3 CYT 12-8.424 9.950 9.356 1.00 0.00 N ATOM 13821 C4 CYT 12-8.530 10.919 10.273 1.00 0.00 C ATOM 13822 N4 CYT 12-8.790 12.165 9.881 1.00 0.00 N ATOM 13823 C5 CYT 12-8.392 10.632 11.666 1.00 0.00 C ATOM 13824 C2'CYT 12-6.436 6.497 11.172 1.00 0. 00 C ATOM 13825 02'CYT 12-6.395 5.112 10.813 1.00 0.00 0 ATOM 13826 C3'CYT 12-5.762 6.747 12.505 1.00 0.00 C ATOM 13827 03'CYT 12-4.649 5.857 12.638 1.00 0.00 O ATOM 13828 1H5'CYT 12-7.460 6.633 15.506 1.00 0.00 H ATOM 13829 2H5'CYT 12-5.701 6.558 15.272 1.00 0.00 H

ATOM 13830 H4'CYT 12-6.857 5.230 13.554 1.00 0.00 H ATOM 13831 H1'CYT 12-8.561 6.328 10.907 1.00 0.00 H ATOM 13832 H6 CYT 12-8.056 9.102 13.078 1.00 0. 00 H ATOM 13833 1H4 CYT 12-8.887 12. 901 10.566 1.00 0.00 H ATOM 13834 2H4 CYT 12-8.898 12.373 8.898 1.00 0.00 H ATOM 13835 H5 CYT 12-8.464 11.423 12.413 1.00 0.00 H ATOM 13836 H2'CYT 12-5.990 7.118 10.394 1.00 0.00 H ATOM 13837 H02'CYT 12-6.917 4.635 11.462 1.00 0.00 H ATOM 13838 H3'CYT 12-5.484 7.795 12.632 1.00 0.00 H ATOM 13839 P URI 13-3.149 6.379 12.379 1.00 0.00 P ATOM 13840 01P URI 13-2.210 5.311 12.788 1.00 0.00 0 ATOM 13841 02P URI 13-3.022 7.735 12.960 1.00 0.00 0 ATOM 13842 05'URI 13-3.097 6.512 10.776 1.00 0.00 0 ATOM 13843 C5'URI 13-2.944 5.351 9.955 1.00 0.00 C ATOM 13844 C4'URI 13-3.151 5.675 8.479 1.00 0.00 C ATOM 13845 04'URI 13-4.464 6.190 8.229 1. 00 0.00 0 ATOM 13846 C1'URI 13-4.387 7.243 7.248 1.00 0.00 C ATOM 13847 N1 URI 13-4.801 8.547 7.816 1.00 0.00 N ATOM 13848 C6 URI 13-4.731 8.792 9.164 1.00 0.00 C ATOM 13849 C2 URI 13-5.269 9.504 6.933 1.00 0.00 C ATOM 13850 02 URI 13-5.334 9.305 5.722 1.00 0.00 0 ATOM 13851 N3 URI 13-5.659 10.706 7.491 1.00 0.00 N ATOM 13852 C4 URI 13-5.623 11.034 8.834 1.00 0.00 C ATOM 13853 04 URI 13-6.006 12.136 9.218 1.00 0.00 0 ATOM 13854 C5 URI 13-5.119 9.981 9.684 1.00 0.00 C ATOM 13855 C2'URI 13-2.933 7.282 6.784 1.00 0.00 C ATOM 13856 02'URI 13-2.718 6.426 5.655 1.00 0.00 0 ATOM 13857 C3'URI 13-2.213 6.775 8.016 1.00 0.00 C ATOM 13858 03'URI 13-0.971 6.186 7.619 1.00 0.00 0 ATOM 13859 1H5'URI 13-3.674 4.600 10.259 1.00 0.00 H ATOM 13860 2H5'URI 13-1. 941 4.948 10.092 1.00 0.00 H ATOM 13861 H4'URI 13-2.994 4.781 7.878 1.00 0. 00 H ATOM 13862 H1'URI 13-5.029 6.994 6.402 1.00 0.00 H ATOM 13863 H6 URI 13-4.355 8. 017 9.832 1.00 0.00 H ATOM 13864 H3 URI 13-6.000 11.412 6.857 1.00 0.00 H ATOM 13865 H5 URI 13-5.051 10.144 10.760 1.00 0.00 H ATOM 13866 H2'URI 13-2.634 8.309 6.562 1.00 0.00 H ATOM 13867 H02'URI 13-3. 038 5.553 5.894 1.00 0.00 H ATOM 13868 H3'URI 13-2.090 7.556 8.769 1.00 0.00 H ATOM 13869 P CYT 14 0.390 7.048 7.658 1.00 0.00 P ATOM 13870 01P CYT 14 1.523 6.135 7.388 1.00 0.00 0 ATOM 13871 02P CYT 14 0.383 7.870 8.889 1.00 0.00 0 ATOM 13872 05'CYT 14 0.220 8.033 6.395 1.00 0.00 0 ATOM 13873 C5'CYT 14 0.461 7.562 5.065 1.00 0.00 C ATOM 13874 C4'CYT 14 0.091 8.614 4.022 1.00 0.00 C ATOM 13875 04'CYT 14-1.292 8.976 4.110 1.00 0.00 0 ATOM 13876 C1'CYT 14-1.432 10.400 3.951 1.00 0.00 C ATOM 13877 N1 CYT 14-1.922 11.040 5.190 1.00 0.00 N ATOM 13878 C6 CYT 14-1.604 10.537 6.418 1.00 0.00 C ATOM 13879 C2 CYT 14-2.703 12.178 5.055 1.00 0.00 C ATOM 13880 02 CYT 14-2.975 12.612 3.938 1.00 0.00 0 ATOM 13881 N3 CYT 14-3.151 12.791 6.182 1.00 0.00 N ATOM 13882 C4 CYT 14-2.847 12.310 7.393 1.00 0.00 C ATOM 13883 N4 CYT 14-3.296 12.942 8.476 1.00 0.00 N ATOM 13884 C5 CYT 14-2.044 11. 137 7.539 1.00 0.00 C ATOM 13885 C2'CYT 14-0.050 10. 925 3.580 1.00 0.00 C ATOM 13886 02'CYT 14 0.140 10.950 2.160 1.00 0.00 0 ATOM 13887 C3'CYT 14 0.853 9.909 4.250 1.00 0.00 C ATOM 13888 03'CYT 14 2.087 9.851 3.529 1.00 0. 00 0 ATOM 13889 1H5'CYT 14-0.133 6.665 4.890 1.00 0.00 H

ATOM 13890 2H5'CYT 14 1.517 7.315 4.961 1.00 0.00 H ATOM 13891 H4'CYT 14 0.302 8.234 3.024 1.00 0.00 H ATOM 13892 H1'CYT 14-2.127 10.606 3.136 1.00 0.00 H ATOM 13893 H6 CYT 14-0.988 9.641 6.493 1.00 0.00 H ATOM 13894 1H4 CYT 14-3.069 12.592 9.395 1.00 0.00 H ATOM 13895 2H4 CYT 14-3.858 13.775 8.376 1.00 0.00 H ATOM 13896 H5 CYT 14-1.795 10.743 8.522 1.00 0.00 H ATOM 13897 H2'CYT 14 0.105 11.916 4.015 1.00 0.00 H ATOM 13898 H02'CYT 14-0.023 10.061 1.835 1.00 0.00 H ATOM 13899 H3'CYT 14 0.994 10.123 5.310 1.00 0.00 H ATOM 13900 P URI 15 3.302 10.837 3.911 1.00 0.00 P ATOM 13901 01P URI 15 3.666 10.595 5.325 1.00 0.00 0 ATOM 13902 02P URI 15 4.334 10.732 2.855 1.00 0.00 0 ATOM 13903 05'URI 15 2.619 12.294 3.810 1.00 0.00 0 ATOM 13904 C5'URI 15 2.412 12.921 2.539 1.00 0.00 C ATOM 13905 C4'URI 15 1.745 14.287 2.689 1.00 0.00 C ATOM 13906 04'URI 15 0.433 14.179 3.261 1.00 0.00 0 ATOM 13907 C1'URI 15 0.260 15.191 4.271 1.00 0.00 C ATOM 13908 N1 URI 15 0.212 14.590 5.622 1.00 0.00 N ATOM 13909 C6 URI 15 1.017 13.531 5.947 1.00 0.00 C ATOM 13910 C2 URI 15-0.667 15.137 6.542 1.00 0.00 C ATOM 13911 02 URI 15-1.396 16.089 6.271 1.00 0.00 0 ATOM 13912 N3 URI 15-0.678 14.550 7.793 1.00 0.00 N ATOM 13913 C4 URI 15 0.102 13.482 8.201 1.00 0.00 C ATOM 13914 04 URI 15 0.009 13.040 9.344 1.00 0.00 0 ATOM 13915 C5 URI 15 0.989 12.976 7.179 1.00 0.00 C ATOM 13916 C2'URI 15 1.452 16.133 4.125 1.00 0.00 C ATOM 13917 02'URI 15 1.195 17.164 3.164 1.00 0.00 0 ATOM 13918 C3'URI 15 2.524 15.176 3.645 1.00 0.00 C ATOM 13919 03'URI 15 3.496 15.909 2.892 1.00 0.00 0 ATOM 13920 1H5'URI 15 1.779 12.281 1.924 1.00 0.00 H ATOM 13921 2H5'URI 15 3.375 13.049 2.045 1.00 0.00 H ATOM 13922 H4'URI 15 1.674 14.770 1.716 1.00 0.00 H ATOM 13923 H1'URI 15-0.664 15.740 4.082 1.00 0.00 H ATOM 13924 H6 URI 15 1.690 13.122 5.195 1.00 0.00 H ATOM 13925 H3 URI 15-1.313 14.939 8.475 1.00 0.00 H ATOM 13926 H5 URI 15 1.649 12.140 7.403 1.00 0.00 H ATOM 13927 H2'URI 15 1.726 16.558 5.097 1.00 0.00 H ATOM 13928 H02'URI 15 0.482 17.706 3.512 1.00 0.00 H ATOM 13929 H3'URI 15 2.966 14.610 4.468 1.00 0.00 H ATOM 13930 P URI 16 4.680 16.706 3.634 1.00 0.00 P ATOM 13931 01P URI 16 5.690 17. 083 2.619 1.00 0.00 0 ATOM 13932 02P URI 16 5.088 15.929 4.827 1.00 0.00 0 ATOM 13933 05'URI 16 3.943 18.049 4.135 1.00 0.00 0 ATOM 13934 C5'URI 16 4.703 19.135 4.674 1.00 0.00 C ATOM 13935 C4'URI 16 4.519 20.411 3.864 1.00 0.00 C ATOM 13936 04'URI 16 4.752 20.181 2.466 1.00 0.00 0 ATOM 13937 C1'URI 16 3.638 20.664 1.711 1.00 0.00 C ATOM 13938 N1 URI 16 3.422 19.851 0.495 1.00 0.00 N ATOM 13939 C6 URI 16 3.325 18.486 0.569 1.00 0.00 C ATOM 13940 C2 URI 16 3.324 20.517-0. 716 1.00 0.00 C ATOM 13941 02 URI 16 3.409 21.741-0. 802 1.00 0.00 0 ATOM 13942 N3 URI 16 3.125 19.723-1. 830 1.00 0.00 N ATOM 13943 C4 URI 16 3.016 18.343-1. 843 1.00 0.00 C ATOM 13944 04 URI 16 2.840 17.739-2. 898 1.00 0.00 0 ATOM 13945 C5 URI 16 3.130 17.732-0. 538 1.00 0.00 C ATOM 13946 C2'URI 16 2.451 20.570 2.653 1.00 0.00 C ATOM 13947 02'URI 16 1.416 21.491 2.292 1.00 0.00 0 ATOM 13948 C3'URI 16 3.087 20. 932 3.986 1.00 0.00 C ATOM 13949 03'URI 16 3.143 22.357 4.099 1.00 0.00 0

ATOM 13950 1H5'URI 16 5.751 18.866 4.682 1.00 0.00 H ATOM 13951 2H5'URI 16 4.386 19.322 5.694 1.00 0.00 H ATOM 13952 H4'URI 16 5.213 21.171 4.223 1.00 0.00 H ATOM 13953 H1'URI 16 3.805 21.706 1.435 1.00 0.00 H ATOM 13954 H6 URI 16 3.406 17.998 1.539 1.00 0.00 H ATOM 13955 H3 URI 16 3.050 20.195-2. 720 1.00 0.00 H ATOM 13956 H5 URI 16 3.058 16.648-0. 445 1.00 0.00 H ATOM 13957 H2'URI 16 2.074 19.544 2.685 1.00 0.00 H ATOM 13958 H02'URI 16 0.777 21.496 3.009 1.00 0.00 H ATOM 13959 H3'URI 16 2.558 20.476 4.824 1.00 0.00 H ATOM 13960 P CYT 17 3.546 23.039 5.502 1.00 0.00 P ATOM 13961 O1P CYT 17 4.892 22.559 5.886 1.00 0.00 O ATOM 13962 02P CYT 17 3.281 24.492 5.405 1. 00 0. 00 O ATOM 13963 05'CYT 17 2.473 22.395 6.516 1.00 0.00 0 ATOM 13964 C5'CYT 17 1.081 22.682 6.363 1.00 0.00 C ATOM 13965 C4'CYT 17 0.206 21.761 7.204 1.00 0.00 C ATOM 13966 04'CYT 17 0.425 20.379 6.873 1.00 0.00 0 ATOM 13967 C1'CYT 17 0.626 19.649 8.081 1.00 0.00 C ATOM 13968 N1 CYT 17 1.446 18.445 7.867 1.00 0.00 N ATOM 13969 C6 CYT 17 2.618 18.519 7.190 1.00 0.00 C ATOM 13970 C2 CYT 17 0.975 17.242 8.377 1.00 0.00 C ATOM 13971 02 CYT 17-0.092 17.202 8.988 1.00 0.00 0 ATOM 13972 N3 CYT 17 1.724 16.123 8.181 1.00 0.00 N ATOM 13973 C4 CYT 17 2.882 16.181 7.513 1.00 0.00 C ATOM 13974 N4 CYT 17 3.590 15.066 7.333 1.00 0.00 N ATOM 13975 C5 CYT 17 3.364 17.420 6.989 1.00 0.00 C ATOM 13976 C2'CYT 17 1.309 20.636 9.005 1.00 0.00 C ATOM 13977 02'CYT 17 1.184 20.252 10.380 1.00 0.00 0 ATOM 13978 C3'CYT 17 0.525 21.899 8.694 1.00 0.00 C ATOM 13979 03'CYT 17-0.708 21.849 9.423 1.00 0.00 0 ATOM 13980 1H5'CYT 17 0.809 22.566 5.319 1.00 0.00 H ATOM 13981 2H5'CYT 17 0.900 23.709 6.662 1.00 0.00 H ATOM 13982 H4'CYT 17-0.842 22.010 7.037 1.00 0.00 H ATOM 13983 H1'CYT 17-0.334 19.367 8.496 1.00 0.00 H ATOM 13984 H6 CYT 17 2.956 19.481 6.810 1.00 0.00 H ATOM 13985 1H4 CYT 17 4.465 15.100 6.828 1.00 0.00 H ATOM 13986 2H4 CYT 17 3.254 14.189 7.703 1.00 0.00 H ATOM 13987 H5 CYT 17 4.299 17.473 6.440 1.00 0.00 H ATOM 13988 H2'CYT 17 2.357 20.762 8.719 1.00 0.00 H ATOM 13989 H02'CYT 17 1.654 19.422 10.488 1.00 0.00 H ATOM 13990 H3'CYT 17 1.095 22. 804 8.903 1.00 0.00 H ATOM 13991 P GUA 18-1.658 23.143 9.536 1.00 0.00 P ATOM 13992 01P GUA 18-2.923 22.732 10.185 1.00 0.00 0 ATOM 13993 02P GUA 18-0.863 24.254 10.106 1.00 0.00 0 ATOM 13994 05'GUA 18-1.974 23.484 7.994 1.00 0.00 O ATOM 13995 C5'GUA 18-2.165 24.837 7.576 1.00 0.00 C ATOM 13996 C4'GUA 18-2.570 24.928 6.107 1.00 0.00 C ATOM 13997 04'GUA 18-1.636 24.265 5.263 1.00 0.00 O ATOM 13998 C1'GUA 18-2.320 23.779 4.095 1.00 0.00 C ATOM 13999 N9 GUA 18-1.998 22.360 3.840 1.00 0.00 N ATOM 14000 C4 GUA 18-2.084 21.313 4.734 1.00 0.00 C ATOM 14001 N3 GUA 18-2.497 21.394 6.019 1.00 0.00 N ATOM 14002 C2 GUA 18-2.468 20. 208 6.635 1.00 0.00 C ATOM 14003 N2 GUA 18-2. 838 20.113 7.912 1.00 0.00 N ATOM 14004 N1 GUA 18-2.064 19.037 6.024 1.00 0.00 N ATOM 14005 C6 GUA 18-1.637 18.929 4.707 1.00 0.00 C ATOM 14006 06 GUA 18-1. 298 17.838 4.255 1.00 0.00 0 ATOM 14007 C5 GUA 18-1.664 20.184 4.046 1.00 0.00 C ATOM 14008 N7 GUA 18-1.316 20.507 2.733 1.00 0.00 N ATOM 14009 C8 GUA 18-1.541 21.777 2.707 1.00 0.00 C

ATOM 14010 C2'GUA 18-3.820 23.977 4.343 1.00 0.00 C ATOM 14011 02'GUA 18-4.322 25.099 3.606 1.00 0.00 O ATOM 14012 C3'GUA 18-3.885 24.220 5. 844 1.00 0.00 C ATOM 14013 03'GUA 18-4. 954 25.136 6.125 1.00 0.00 O ATOM 14014 1H5'GUA 18-1.235 25.388 7.722 1.00 0.00 H ATOM 14015 2H5'GUA 18-2.944 25.288 8.187 1.00 0.00 H ATOM 14016 H4'GUA 18-2.648 25.972 5.810 1.00 0.00 H ATOM 14017 H1'GUA 18-2.019 24.375 3.233 1.00 0.00 H ATOM 14018 1H2 GUA 18-2.817 19.218 8. 379 1.00 0.00 H ATOM 14019 2H2 GUA 18-3.140 20.936 8.413 1.00 0.00 H ATOM 14020 H1 GUA 18-2.069 18.179 6.559 1.00 0.00 H ATOM 14021 H8 GUA 18-1.367 22.361 1.806 1.00 0.00 H ATOM 14022 H2'GUA 18-4.367 23.066 4.084 1.00 0.00 H ATOM 14023 H02'GUA 18-5.266 25.148 3.771 1.00 0.00 H ATOM 14024 H3'GUA 18-3.971 23.288 6.406 1.00 0.00 H ATOM 14025 P GUA 19-6.496 24.704 5.928 1.00 0.00 P ATOM 14026 O1P GUA 19-7. 338 25.620 6.729 1.00 0.00 0 ATOM 14027 02P GUA 19-6.752 24.550 4.478 1.00 0.00 0 ATOM 14028 05'GUA 19-6.543 23.247 6.617 1.00 0.00 0 ATOM 14029 C5'GUA 19-7.389 22.211 6.104 1.00 0.00 C ATOM 14030 C4'GUA 19-6.958 21.769 4.706 1.00 0. 00 C ATOM 14031 04'GUA 19-5.553 21.466 4.660 1.00 0.00 0 ATOM 14032 Cl'GUA 19-5.371 20.143 4.135 1.00 0.00 C ATOM 14033 N9 GUA 19-5.170 19.166 5.222 1.00 0.00 N ATOM 14034 C4 GUA 19-4.773 17.855 5.088 1.00 0.00 C ATOM 14035 N3 GUA 19-4.479 17.232 3.926 1.00 0.00 N ATOM 14036 C2 GUA 19-4. 123 15.959 4.113 1.00 0.00 C ATOM 14037 N2 GUA 19-3. 802 15.199 3.068 1.00 0.00 N ATOM 14038 N1 GUA 19-4.064 15.354 5.355 1.00 0.00 N ATOM 14039 C6 GUA 19-4.361 15.974 6.560 1.00 0.00 C ATOM 14040 06 GUA 19-4.281 15.347 7.613 1.00 0.00 0 ATOM 14041 C5 GUA 19-4.740 17.328 6.369 1.00 0.00 C ATOM 14042 N7 GUA 19-5.112 18.293 7.309 1.00 0.00 N ATOM 14043 C8 GUA 19-5.339 19.315 6.557 1.00 0.00 C ATOM 14044 C2'GUA 19-6.648 19.848 3.369 1.00 0.00 C ATOM 14045 02'GUA 19-6.642 20.461 2.074 1.00 0.00 0 ATOM 14046 C3'GUA 19-7.668 20.484 4.290 1.00 0.00 C ATOM 14047 03'GUA 19-8.832 20.821 3.530 1.00 0.00 O ATOM 14048 1H5'GUA 19-8.416 22.575 6.062 1.00 0.00 H ATOM 14049 2H5'GUA 19-7.344 21.355 6.777 1.00 0.00 H ATOM 14050 H4'GUA 19-7.180 22.557 3.988 1.00 0.00 H ATOM 14051 H1'GUA 19-4.518 20.126 3.457 1.00 0.00 H ATOM 14052 1H2 GUA 19-3.828 15.587 2.135 1.00 0.00 H ATOM 14053 2H2 GUA 19-3.532 14.237 3.206 1.00 0.00 H ATOM 14054 H1 GUA 19-3.782 14.387 5.414 1.00 0.00 H ATOM 14055 H8 GUA 19-5.647 20.269 6.982 1.00 0.00 H ATOM 14056 H2'GUA 19-6.809 18.770 3.299 1.00 0.00 H ATOM 14057 H02'GUA 19-5.994 19.996 1.540 1.00 0.00 H ATOM 14058 H3'GUA 19-7.896 19.846 5.146 1.00 0.00 H ATOM 14059 P ADE 20-10.077 19.801 3.455 1.00 0.00 P ATOM 14060 01P ADE 20-11.150 20.436 2.658 1.00 0.00 0 ATOM 14061 02P ADE 20-10.362 19.318 4.826 1.00 0.00 0 ATOM 14062 05'ADE 20-9.473 18.573 2.607 1.00 0.00 O ATOM 14063 C5'ADE 20-9.250 18. 698 1.200 1.00 0.00 C ATOM 14064 C4'ADE 20-8.595 17.446 0.624 1.00 0.00 C ATOM 14065 04'ADE 20-7.310 17.201 1.217 1.00 0.00 0 ATOM 14066 C1'ADE 20-7.205 15.810 1.577 1.00 0.00 C ATOM 14067 N9 ADE 20-7.293 15.628 3.041 1.00 0.00 N ATOM 14068 C4 ADE 20-6.872 14.532 3.760 1.00 0.00 C ATOM 14069 N3 ADE 20-6.314 13.412 3.260 1.00 0.00 N

ATOM 14070 C2 ADE 20-6.021 12.546 4.224 1.00 0.00 C ATOM 14071 N1 ADE 20-6.223 12.699 5.533 1.00 0.00 N ATOM 14072 C6 ADE 20-6.779 13.826 6.009 1.00 0.00 C ATOM 14073 N6 ADE 20-6.958 13.966 7.322 1.00 0.00 N ATOM 14074 C5 ADE 20-7.133 14.810 5.082 1.00 0.00 C ATOM 14075 N7 ADE 20-7.719 16.072 5.219 1.00 0.00 N ATOM 14076 C8 ADE 20-7.773 16.467 3.992 1.00 0.00 C ATOM 14077 C2'ADE 20-8.362 15.120 0.871 1.00 0.00 C ATOM 14078 02'ADE 20-8.029 14.782-0. 482 1.00 0.00 0 ATOM 14079 C3'ADE 20-9.415 16.204 0.935 1.00 0.00 C ATOM 14080 03'ADE 20-10.360 15.996-0. 117 1.00 0.00 O ATOM 14081 1H5'ADE 20-8.602 19.555 1.015 1.00 0.00 H ATOM 14082 2H5'ADE 20-10.206 18.859 0.701 1.00 0.00 H ATOM 14083 H4'ADE 20-8.481 17. 551-0.453 1.00 0.00 H ATOM 14084 H1'ADE 20-6.260 15.408 1.212 1.00 0.00 H ATOM 14085 H2 ADE 20-5.564 11.606 3.911 1.00 0.00 H ATOM 14086 1H6 ADE 20-7.367 14.813 7.689 1.00 0.00 H ATOM 14087 2H6 ADE 20-6.679 13.226 7.952 1.00 0.00 H ATOM 14088 H8 ADE 20-8.197 17.436 3.730 1.00 0.00 H ATOM 14089 H2'ADE 20-8.680 14.240 1.433 1.00 0.00 H ATOM 14090 H02'ADE 20-7.756 15.591-0. 920 1.00 0.00 H ATOM 14091 H3'ADE 20-9. 885. 16.257 1. 919 1.00 0.00 H ATOM 14092 P GUA 21-11.652 15.067 0.128 1.00 0.00 P ATOM 14093 O1P GUA 21-12.253 15.440 1.428 1.00 0.00 0 ATOM 14094 02P GUA 21-12. 479 15.088-1. 100 1.00 0.00 0 ATOM 14095 05'GUA 21-11.004 13.601 0.277 1.00 0.00 0 ATOM 14096 C5'GUA 21-10.561 12.881-0. 877 1.00 0.00 C ATOM 14097 C4'GUA 21-10. 099 11.472-0. 517 1.00 0.00 C ATOM 14098 04'GUA 21-8.957 11.493 0.351 1.00 0.00 0 ATOM 14099 C1'GUA 21-9. 139 10.533 1.409 1.00 0.00 C ATOM 14100 N9 GUA 21-9.359 11.207 2.705 1.00 0.00 N ATOM 14101 C4 GUA 21-9.074 10.702 3.955 1.00 0.00 C ATOM 14102 N3 GUA 21-8.589 9.467 4.221 1.00 0.00 N ATOM 14103 C2 GUA 21-8. 415 9.265 5.531 1.00 0.00 C ATOM 14104 N2 GUA 21-7.966 8.089 5.970 1.00 0.00 N ATOM 14105 N1 GUA 21-8.693 10.212 6.496 1.00 0. 00 N ATOM 14106 C6 GUA 21-9.188 11.485 6.247 1.00 0.00 C ATOM 14107 06 GUA 21-9.387 12.262 7.178 1.00 0.00 0 ATOM 14108 C5 GUA 21-9.382 11.707 4.859 1.00 0.00 C ATOM 14109 N7 GUA 21-9.863 12.837 4.193 1.00 0.00 N ATOM 14110 C8 GUA 21-9.817 12.456 2.961 1.00 0.00 C ATOM 14111 C2'GUA 21-10. 346 9.697 1.003 1.00 0.00 C ATOM 14112 02'GUA 21-9.968 8.606 0. 154 1.00 0.00 0 ATOM 14113 C3'GUA 21-11.171 10.725 0.259 1.00 0.00 C ATOM 14114 03'GUA 21-12.027 10.054-0. 671 1.00 0.00 O ATOM 14115 1H5'GUA 21-9.733 13.420-1. 339 1.00 0.00 H ATOM 14116 2H5'GUA 21-11.383 12.813-1. 590 1.00 0.00 H ATOM 14117 H4'GUA 21-9.853 10.923-1. 424 1.00 0.00 H ATOM 14118 H1'GUA 21-8.257 9.894 1.477 1.00 0.00 H ATOM 14119 1H2 GUA 21-7. 756 7.352 5.314 1.00 0.00 H ATOM 14120 2H2 GUA 21-7.843 7.934 6.961 1.00 0.00 H ATOM 14121 H1 GUA 21-8.530 9.982 7.466 1.00 0.00 H ATOM 14122 H8 GUA 21-10.152 13.109 2.157 1.00 0.00 H ATOM 14123 H2'GUA 21-10.879 9.344 1.888 1.00 0.00 H ATOM 14124 H02'GUA 21-9.453 8.972-0. 568 1.00 0.00 H ATOM 14125 H3'GUA 21-11.719 11. 380 0.939 1.00 0.00 H ATOM 14126 P ADE 22-13.525 9.635-0. 251 1.00 0.00 P ATOM 14127 O1P ADE 22-14.261 9.253-1. 477 1.00 0. 00 0 ATOM 14128 02P ADE 22-14.070 10.685 0.639 1.00 0.00 0 ATOM 14129 05'ADE 22-13. 284 8.307 0.626 1.00 0.00 0

ATOM 14130 C5'ADE 22-12.769 7.119 0.017 1.00 0. 00 C ATOM 14131 C4'ADE 22-12.158 6.177 1.050 1.00 0.00 C ATOM 14132 04'ADE 22-11.140 6.833 1.817 1.00 0.00 0 ATOM 14133 C1'ADE 22-11.278 6.480 3.204 1.00 0.00 C ATOM 14134 N9 ADE 22-11.700 7.640 4.016 1.00 0.00 N ATOM 14135 C4 ADE 22-11.411 7.856 5.343 1.00 0.00 C ATOM 14136 N3 ADE 22-10.705 7.039 6.148 1.00 0.00 N ATOM 14137 C2 ADE 22-10.604 7.539 7.373 1.00 0.00 C ATOM 14138 N1 ADE 22-11.108 8.692 7.818 1.00 0.00 N ATOM 14139 C6 ADE 22-11.810 9.491 6.995 1.00 0.00 C ATOM 14140 N6 ADE 22-12.302 10.640 7.458 1.00 0.00 N ATOM 14141 C5 ADE 22-11.981 9.063 5.676 1.00 0.00 C ATOM 14142 N7 ADE 22-12.637 9.623 4.576 1.00 0.00 N ATOM 14143 C8 ADE 22-12.423 8.734 3.666 1.00 0.00 C ATOM 14144 C2'ADE 22-12.315 5.366 3.252 1.00 0.00 C ATOM 14145 02'ADE 22-11.704 4.081 3.088 1.00 0.00 0 ATOM 14146 C3'ADE 22-13.191 5.725 2. 070 1.00 0.00 C ATOM 14147 03'ADE 22-13.824 4.535 1.586 1.00 0.00 O ATOM 14148 1H5'ADE 22-12.004 7.394-0. 708 1.00 0.00 H ATOM 14149 2H5'ADE 22-13. 580 6.603-0. 499 1.00 0.00 H ATOM 14150 H4'ADE 22-11.731 5.309 0.550 1. 00 0.00 H ATOM 14151 H1'ADE 22-10. 325 6.104 3.577 1.00 0.00 H ATOM 14152 H2 ADE 22-10.049 6.941 8.096 1.00 0.00 H ATOM 14153 1H6 ADE 22-12.828 11.247 6.846 1.00 0.00 H ATOM 14154 2H6 ADE 22-12. 148 10.904 8.421 1.00 0.00 H ATOM 14155 H8 ADE 22-12.813 8.855 2.657 1.00 0.00 H ATOM 14156 H2'ADE 22-12. 886 5.417 4.183 1.00 0.00 H ATOM 14157 H02'ADE 22-11. 353 3.821 3.943 1.00 0.00 H ATOM 14158 H3'ADE 22-13.904 6.514 2.313 1.00 0.00 H ATOM 14159 P CYT 23-15.127 3.939 2.323 1.00 0.00 P ATOM 14160 01P CYT 23-16.029 5.065 2.653 1.00 0.00 0 ATOM 14161 02P CYT 23-15. 632 2.801 1.523 1.00 0.00 0 ATOM 14162 05'CYT 23-14.522 3.360 3.700 1.00 0.00 O ATOM 14163 C5'CYT 23-13. 637 2.235 3.693 1.00 0.00 C ATOM 14164 C4'CYT 23-12.991 2.019 5.059 1.00 0.00 C ATOM 14165 04'CYT 23-12.309 3.190 5.511 1.00 0.00 0 ATOM 14166 C1'CYT 23-12.446 3.309 6.939 1.00 0.00 C ATOM 14167 N1 CYT 23-13.073 4.598 7.311 1.00 0.00 N ATOM 14168 C6 CYT 23-14.109 5.116 6.586 1.00 0.00 C ATOM 14169 C2 CYT 23-12.563 5.263 8.420 1.00 0.00 C ATOM 14170 02 CYT 23-11.630 4.778 9.058 1.00 0.00 0 ATOM 14171 N3 CYT 23-13.121 6.452 8.773 1.00 0.00 N ATOM 14172 C4 CYT 23-14.135 6.972 8.071 1.00 0.00 C ATOM 14173 N4 CYT 23-14. 657 8.140 8. 445 1.00 0.00 N ATOM 14174 C5 CYT 23-14.665 6.293 6.930 1.00 0.00 C ATOM 14175 C2'CYT 23-13.297 2.122 7.397 1.00 0.00 C ATOM 14176 02'CYT 23-12.478 1.047 7.874 1.00 0.00 0 ATOM 14177 C3'CYT 23-14.034 1.741 6.124 1.00 0.00 C ATOM 14178 03'CYT 23-14.291 0.332 6.139 1.00 0.00 0 ATOM 14179 1H5'CYT 23-12.854 2.403 2.953 1.00 0.00 H ATOM 14180 2H5'CYT 23-14.199 1.341 3.420 1.00 0.00 H ATOM 14181 H4'CYT 23-12.288 1.189 5.008 1.00 0.00 H ATOM 14182 Hl'CYT 23-11.459 3.243 7.399 1.00 0.00 H ATOM 14183 H6 CYT 23-14.487 4.573 5.720 1.00 0. 00 H ATOM 14184 1H4 CYT 23-15.423 8.541 7.922 1.00 0.00 H ATOM 14185 2H4 CYT 23-14.286 8.624 9.249 1.00 0.00 H ATOM 14186 H5 CYT 23-15.492 6. 714 6.359 1.00 0.00 H ATOM 14187 H2'CYT 23-14. 007 2.442 8.165 1.00 0.00 H ATOM 14188 H02'CYT 23-12. 122 1.316 8.725 1.00 0. 00 H ATOM 14189 H3'CYT 23-14.939 2.333 5.981 1.00 0.00 H

ATOM 14190 P GUA 24-15.624-0. 261 6.821 1. 00 0.00 P ATOM 14191 01P GUA 24-16.729 0.698 6.595 1.00 0.00 O ATOM 14192 02P GUA 24-15.773-1. 671 6.396 1.00 0.00 0 ATOM 14193 05'GUA 24-15.254-0. 243 8.388 1.00 0.00 0 ATOM 14194 C5'GUA 24-14.214-1. 081 8.902 1.00 0.00 C ATOM 14195 C4'GUA 24-14.199-1. 086 10.428 1.00 0.00 C ATOM 14196 04'GUA 24-13.973 0.231 10.958 1.00 0.00 0 ATOM 14197 Cl'GUA 24-14.972 0.523 11.950 1.00 0.00 C ATOM 14198 N9 GUA 24-16.008 1.424 11.414 1.00 0.00 N ATOM 14199 C4 GUA 24-16.992 2.057 12.135 1.00 0.00 C ATOM 14200 N3 GUA 24-17.178 1.961 13.471 1.00 0.00 N ATOM 14201 C2 GUA 24-18. 216 2.690 13.888 1.00 0.00 C ATOM 14202 N2 GUA 24-18.548 2.699 15.178 1.00 0.00 N ATOM 14203 N1 GUA 24-19.001 3.452 13.047 1.00 0.00 N ATOM 14204 C6 GUA 24-18.829 3.566 11.675 1.00 0.00 C ATOM 14205 06 GUA 24-19.589 4.268 11.014 1.00 0.00 0 ATOM 14206 C5 GUA 24-17.729 2.793 11.223 1.00 0.00 C ATOM 14207 N7 GUA 24-17.220 2.631 9.931 1.00 0.00 N ATOM 14208 C8 GUA 24-16.233 1.827 10.139 1.00 0. 00 C ATOM 14209 C2'GUA 24-15.562-0. 824 12.331 1.00 0.00 C ATOM 14210 02'GUA 24-14.747-1. 505 13.294 1.00 0.00 O ATOM 14211 C3'GUA 24-15.547-1. 522 10.988 1.00 0.00 C ATOM 14212 03'GUA 24-15.522-2. 937 11.198 1.00 0.00 0 ATOM 14213 1H5'GUA 24-13.252-0. 720 8.537 1.00 0.00 H ATOM 14214 2H5'GUA 24-14.370-2. 100 8.545 1.00 0.00 H ATOM 14215 H4'GUA 24-13.419-1. 758 10.785 1.00 0.00 H ATOM 14216 H1'GUA 24-14.507 0.982 12.823 1.00 0.00 H ATOM 14217 1H2 GUA 24-18.015 2.153 15.840 1.00 0.00 H ATOM 14218 2H2 GUA 24-19.334 3.250 15.494 1.00 0.00 H ATOM 14219 Hl GUA 24-19.762 3.979 13.440 1.00 0.00 H ATOM 14220 H8 GUA 24-15.603 1.484 9.319 1.00 0.00 H ATOM 14221 H2'GUA 24-16.586-0. 704 12.692 1.00 0.00 H ATOM 14222 H02'GUA 24-14.877-1. 067 14.139 1.00 0.00 H ATOM 14223 H3'GUA 24-16.377-1. 204 10.355 1.00 0.00 H ATOM 14224 P ADE 25-16. 889-3.789 11.179 1.00 0.00 P ATOM 14225 01P ADE 25-17.698-3. 344 10.023 1.00 0.00 0 ATOM 14226 02P ADE 25-16.544-5. 221 11.330 1.00 0.00 0 ATOM 14227 05'ADE 25-17.624-3. 301 12.526 1.00 0.00 0 ATOM 14228 C5'ADE 25-17.063-3. 605 13.806 1.00 0.00 C ATOM 14229 C4'ADE 25-17.658-2. 732 14.908 1.00 0.00 C ATOM 14230 04'ADE 25-17. 514-1. 335 14.616 1.00 0. 00 0 ATOM 14231 C1'ADE 25-18.732-0. 648 14.965 1.00 0.00 C ATOM 14232 N9 ADE 25-19.448-0. 175 13.763 1.00 0.00 N ATOM 14233 C4 ADE 25-20.528 0.676 13.735 1.00 0.00 C ATOM 14234 N3 ADE 25-21.137 1.229 14.803 1.00 0.00 N ATOM 14235 C2 ADE 25-22.149 2.005 14.433 1.00 0.00 C ATOM 14236 N1 ADE 25-22.563 2.251 13.190 1. 00 0.00 N ATOM 14237 C6 ADE 25-21.939 1.689 12.141 1.00 0.00 C ATOM 14238 N6 ADE 25-22.365 1.953 10.908 1.00 0.00 N ATOM 14239 C5 ADE 25-20.856 0.848 12.411 1.00 0.00 C ATOM 14240 N7 ADE 25-19.999 0.114 11.587 1.00 0.00 N ATOM 14241 C8 ADE 25-19.222-0. 444 12.452 1.00 0.00 C ATOM 14242 C2'ADE 25-19.571-1. 661 15.731 1.00 0.00 C ATOM 14243 02'ADE 25-19. 237-1.674 17.124 1.00 0. 00 0 ATOM 14244 C3'ADE 25-19.156-2. 943 15.045 1.00 0.00 C ATOM 14245 03'ADE 25-19.392-4. 039 15.932 1.00 0.00 0 ATOM 14246 1H5'ADE 25-15.986-3. 442 13.769 1.00 0.00 H ATOM 14247 2H5'ADE 25-17.256-4. 652 14. 040 1.00 0. 00 H ATOM 14248 H4'ADE 25-17.169-2. 952 15.855 1.00 0.00 H ATOM 14249 H1'ADE 25-18.502 0.198 15.611 1.00 0.00 H

ATOM 14250 H2 ADE 25-22.702 2.496 15.235 1.00 0.00 H ATOM 14251 1H6 ADE 25-21.900 1.539 10.113 1.00 0.00 H ATOM 14252 2H6 ADE 25-23.152 2. 570 10. 767 1.00 0.00 H ATOM 14253 H8 ADE 25-18.420-1. 113 12.142 1.00 0.00 H ATOM 14254 H2'ADE 25-20.636-1. 470 15.579 1.00 0. 00 H ATOM 14255 H02'ADE 25-19.313-2. 582 17.426 1.00 0.00 H ATOM 14256 H3'ADE 25-19.651-3. 066 14.079 1.00 0.00 H ATOM 14257 P CYT 26-20.847-4. 723 16.001 1.00 0.00 P ATOM 14258 O1P CYT 26-21.276-5. 041 14.621 1.00 0.00 O ATOM 14259 02P CYT 26-20. 810-5.790 17.027 1. 00 0.00 O ATOM 14260 05'CYT 26-21. 768-3.523 16.551 1.00 0.00 O ATOM 14261 C5'CYT 26-21.774-3. 191 17.942 1.00 0.00 C ATOM 14262 C4'CYT 26-22.917-2. 243 18.291 1.00 0.00 C ATOM 14263 04'CYT 26-22. 768-0. 960 17.670 1.00 0.00 O ATOM 14264 C1'CYT 26-24.063-0. 498 17.228 1.00 0.00 C ATOM 14265 N1 CYT 26-24.141-0. 445 15.753 1. 00 0.00 N ATOM 14266 C6 CYT 26-23.432-1. 320 14.982 1.00 0.00 C ATOM 14267 C2 CYT 26-24.984 0.503 15.186 1.00 0.00 C ATOM 14268 02 CYT 26-25.609 1.284 15.901 1.00 0.00 O ATOM 14269 N3 CYT 26-25.093 0.538 13.830 1.00 0.00 N ATOM 14270 C4 CYT 26-24.407-0. 317 13.063 1.00 0.00 C ATOM 14271 N4 CYT 26-24. 542-0.256 11.738 1.00 0.00 N ATOM 14272 C5 CYT 26-23.537-1. 293 13.645 1.00 0.00 C ATOM 14273 C2'CYT 26-25.071-1. 498 17.785 1.00 0.00 C ATOM 14274 02'CYT 26-25. 484-1.148 19.112 1.00 0.00 O ATOM 14275 C3'CYT 26-24.242-2. 763 17.770 1.00 0.00 C ATOM 14276 03'CYT 26-24. 776-3.692 18.716 1.00 0.00 0 ATOM 14277 1H5'CYT 26-20.828-2. 717 18.201 1.00 0.00 H ATOM 14278 2H5'CYT 26-21.884-4. 107 18.523 1.00 0.00 H ATOM 14279 H4'CYT 26-22.972-2. 116 19.371 1.00 0.00 H ATOM 14280 H1'CYT 26-24. 261 0.489 17. 642 1.00 0.00 H ATOM 14281 H6 CYT 26-22. 767-2.044 15.455 1.00 0.00 H ATOM 14282 1H4 CYT 26-24.032-0. 898 11.148 1.00 0.00 H ATOM 14283 2H4 CYT 26-25.157 0.430 11.324 1.00 0.00 H ATOM 14284 H5 CYT 26-22.992-2. 003 13.030 1.00 0.00 H ATOM 14285 H2'CYT 26-25.928-1. 589 17.112 1.00 0.00 H ATOM 14286 H02'CYT 26-24.689-1. 019 19.634 1.00 0.00 H ATOM 14287 H3'CYT 26-24.153-3. 181 16.762 1.00 0.00 H ATOM 14288 P CYT 27-25.189-5. 179 18.257 1.00 0.00 P ATOM 14289 01P CYT 27-24.261-5. 611 17.186 1.00 0.00 O ATOM 14290 02P CYT 27-25.355-6. 011 19.470 1.00 0.00 O ATOM 14291 05'CYT 27-26.640-4. 946 17.601 1.00 0.00 O ATOM 14292 C5'CYT 27-27. 706-4.402 18.384 1.00 0.00 C ATOM 14293 C4'CYT 27-28.595-3. 475 17.561 1. 00 0.00 C ATOM 14294 04'CYT 27-27.836-2. 453 16.905 1.00 0.00 O ATOM 14295 C1'CYT 27-28.410-2. 194 15.607 1.00 0.00 C ATOM 14296 N1 CYT 27-27.467-2. 518 14.512 1.00 0.00 N ATOM 14297 C6 CYT 27-26.398-3. 346 14.715 1.00 0. 00 C ATOM 14298 C2 CYT 27-27.727-1. 968 13.263 1.00 0.00 C ATOM 14299 02 CYT 27-28.697-1. 230 13.102 1.00 0.00 O ATOM 14300 N3 CYT 27-26.891-2. 272 12.236 1.00 0.00 N ATOM 14301 C4 CYT 27-25.842-3. 083 12.417 1.00 0.00 C ATOM 14302 N4 CYT 27-25.043-3. 353 11.387 1.00 0.00 N ATOM 14303 C5 CYT 27-25. 566-3. 656 13.699 1.00 0.00 C ATOM 14304 C2'CYT 27-29.660-3. 068 15.520 1.00 0.00 C ATOM 14305 02'CYT 27-30. 819-2. 374 15.998 1.00 0.00 O ATOM 14306 C3'CYT 27-29.280-4. 217 16.430 1.00 0.00 C ATOM 14307 03'CYT 27-30. 474-4.829 16.929 1.00 0.00 0 ATOM 14308 1H5'CYT 27-27.284-3. 839 19.217 1.00 0.00 H ATOM 14309 2H5'CYT 27-28.311-5. 218 18. 778 1.00 0.00 H

ATOM 14310 H4'CYT 27-29.342-3. 013 18.204 1.00 0.00 H ATOM 14311 H1'CYT 27-28.697-1. 144 15.541 1.00 0.00 H ATOM 14312 H6 CYT 27-26. 208-3. 749 15.710 1.00 0.00 H ATOM 14313 1H4 CYT 27-24.246-3. 961 11.512 1.00 0.00 H ATOM 14314 2H4 CYT 27-25.233-2. 948 10.481 1.00 0.00 H ATOM 14315 H5 CYT 27-24.718-4. 328 13.844 1.00 0.00 H ATOM 14316 H2'CYT 27-29.806-3. 422 14.497 1.00 0.00 H ATOM 14317 H02'CYT 27-31.063-1. 731 15.328 1.00 0.00 H ATOM 14318 H3'CYT 27-28.613-4. 927 15.937 1.00 0.00 H ATOM 14319 P GUA 28-31.195-6. 010 16.103 1.00 0.00 P ATOM 14320 O1P GUA 28-32.390-6. 442 16.861 1.00 0.00 0 ATOM 14321 02P GUA 28-30.167-7. 003 15.719 1.00 0.00 0 ATOM 14322 05'GUA 28-31.688-5. 254 14.769 1.00 0.00 O ATOM 14323 C5'GUA 28-32.710-4. 256 14.839 1.00 0.00 C ATOM 14324 C4'GUA 28-32.859-3. 504 13.519 1.00 0.00 C ATOM 14325 04'GUA 28-31.638-2. 889 13.110 1.00 0.00 0 ATOM 14326 Cl'GUA 28-31.612-2. 820 11.670 1.00 0.00 C ATOM 14327 N9 GUA 28-30.378-3. 416 11.115 1.00 0.00 N ATOM 14328 C4 GUA 28-29.952-3. 334 9.809 1.00 0.00 C ATOM 14329 N3 GUA 28-30.593-2. 688 8.810 1.00 0.00 N ATOM 14330 C2 GUA 28-29.941-2. 781 7.648 1.00 0.00 C ATOM 14331 N2 GUA 28-30.443-2. 202 6.559 1.00 0.00 N ATOM 14332 N1 GUA 28-28.748-3. 459 7.491 1.00 0.00 N ATOM 14333 C6 GUA 28-28.070-4. 129 8.501 1.00 0.00 C ATOM 14334 06 GUA 28-27.008-4. 699 8.258 1.00 0.00 0 ATOM 14335 C5 GUA 28-28.759-4. 036 9.742 1.00 0.00 C ATOM 14336 N7 GUA 28-28.428-4. 562 10.995 1.00 0.00 N ATOM 14337 C8 GUA 28-29.416-4. 155 11.721 1.00 0.00 C ATOM 14338 C2'GUA 28-32.849-3. 578 11.177 1.00 0.00 C ATOM 14339 02'GUA 28-33.916-2. 680 10.847 1.00 0.00 0 ATOM 14340 C3'GUA 28-33.193-4. 439 12.378 1.00 0.00 C ATOM 14341 03'GUA 28-34.602-4. 690 12.380 1.00 0.00 0 ATOM 14342 1H5'GUA 28-32.459-3. 544 15.626 1.00 0.00 H ATOM 14343 2H5'GUA 28-33.658-4. 736 15.083 1.00 0.00 H ATOM 14344 H4'GUA 28-33.633-2. 744 13.612 1.00 0.00 H ATOM 14345 Hl'GUA 28-31.682-1. 778 11.358 1.00 0.00 H ATOM 14346 1H2 GUA 28-31.314-1. 694 6.613 1.00 0.00 H ATOM 14347 2H2 GUA 28-29.954-2. 273 5.679 1.00 0.00 H ATOM 14348 Hl GUA 28-28.317-3. 482 6.578 1.00 0.00 H ATOM 14349 H8 GUA 28-29.476-4. 401 12.780 1.00 0.00 H ATOM 14350 H2'GUA 28-32.588-4. 207 10.323 1.00 0.00 H ATOM 14351 H02'GUA 28-33.679-2. 246 10.024 1.00 0.00 H ATOM 14352 H3'GUA 28-32. 600-5.355 12.408 1.00 0.00 H ATOM 14353 P CYT 29-35.221-5. 880 11.488 1.00 0.00 P ATOM 14354 01P CYT 29-34.292-7. 031 11.541 1.00 0.00 0 ATOM 14355 02P CYT 29-36.639-6. 059 11.873 1.00 0.00 0 ATOM 14356 05'CYT 29-35.175-5. 266 9.999 1.00 0.00 0 ATOM 14357 C5'CYT 29-36.135-4. 290 9.583 1.00 0.00 C ATOM 14358 C4'CYT 29-35.941-3. 899 8.120 1.00 0.00 C ATOM 14359 04'CYT 29-34.650-3. 320 7.891 1.00 0.00 O ATOM 14360 C1'CYT 29-34.097-3. 840 6.666 1.00 0.00 C ATOM 14361 N1 CYT 29-32.920-4. 700 6.930 1.00 0.00 N ATOM 14362 C6 CYT 29-32.777-5. 349 8.122 1.00 0.00 C ATOM 14363 C2 CYT 29-31.959-4. 802 5.931 1.00 0.00 C ATOM 14364 02 CYT 29-32.112-4. 218 4.860 1.00 0.00 0 ATOM 14365 N3 CYT 29-30.859-5. 567 6.171 1.00 0.00 N ATOM 14366 C4 CYT 29-30.705-6. 206 7.338 1.00 0.00 C ATOM 14367 N4 CYT 29-29.611-6. 939 7.544 1.00 0.00 N ATOM 14368 C5 CYT 29-31.693-6. 107 8.367 1.00 0.00 C ATOM 14369 C2'CYT 29-35.221-4. 628 6.003 1.00 0.00 C

ATOM 14370 02'CYT 29-36.026-3. 789 5.166 1.00 0.00 0 ATOM 14371 C3'CYT 29-35.991-5. 117 7.212 1.00 0.00 C ATOM 14372 03'CYT 29-37.351-5. 351 6.833 1.00 0.00 0 ATOM 14373 1H5'CYT 29-36.032-3. 401 10.205 1.00 0.00 H ATOM 14374 2H5'CYT 29-37.137-4. 700 9.711 1.00 0.00 H ATOM 14375 H4'CYT 29-36.712-3. 189 7.823 1.00 0.00 H ATOM 14376 H1'CYT 29-33.805-3. 011 6.020 1.00 0.00 H ATOM 14377 H6 CYT 29-33.553-5. 256 8. 883 1.00 0.00 H ATOM 14378 1H4 CYT 29-29.483-7. 420 8.422 1.00 0.00 H ATOM 14379 2H4 CYT 29-28.911-7. 015 6.819 1.00 0.00 H ATOM 14380 H5 CYT 29-31.571-6. 627 9.317 1.00 0.00 H ATOM 14381 H2'CYT 29-34.813-5. 471 5.441 1.00 0.00 H ATOM 14382 H02'CYT 29-36.840-4. 265 4.985 1.00 0.00 H ATOM 14383 H3'CYT 29-35.523-5. 990 7.669 1.00 0.00 H ATOM 14384 P CYT 30-37.858-6. 839 6.482 1.00 0.00 P ATOM 14385 01P CYT 30-37.269-7. 774 7.467 1.00 0.00 0 ATOM 14386 02P CYT 30-39.324-6. 796 6.292 1.00 0.00 0 ATOM 14387 05'CYT 30-37.170-7. 116 5.052 1.00 0.00 0 ATOM 14388 C5'CYT 30-37.644-6. 452 3.876 1.00 0.00 C ATOM 14389 C4'CYT 30-36.616-6. 505 2. 749 1.00 0.00 C ATOM 14390 04'CYT 30-35.358-5. 959 3.155 1.00 0.00 0 ATOM 14391 C1'CYT 30-34.296-6. 719 2. 551 1.00 0.00 C ATOM 14392 N1 CYT 30-33.451-7. 379 3.572 1.00 0.00 N ATOM 14393 C6 CYT 30-33.954-7. 717 4.797 1.00 0.00 C ATOM 14394 C2 CYT 30-32.131-7. 644 3.235 1.00 0.00 C ATOM 14395 02 CYT 30-31.702-7. 339 2.124 1.00 0.00 0 ATOM 14396 N3 CYT 30-31.338-8. 251 4.159 1.00 0.00 N ATOM 14397 C4 CYT 30-31.817-8. 587 5.363 1. 00 0.00 C ATOM 14398 N4 CYT 30-31.011-9. 185 6.241 1.00 0.00 N ATOM 14399 C5 CYT 30-33.176-8. 318 5.717 1.00 0.00 C ATOM 14400 C2'CYT 30-34.975-7. 747 1.648 1.00 0.00 C ATOM 14401 02'CYT 30-35.144-7. 244 0.318 1.00 0.00 0 ATOM 14402 C3'CYT 30-36.306-7. 934 2.346 1.00 0.00 C ATOM 14403 03'CYT 30-37.300-8. 471 1.466 1.00 0.00 0 ATOM 14404 1H5'CYT 30-37.856-5. 411 4.115 1.00 0.00 H ATOM 14405 2H5'CYT 30-38.563-6. 935 3.542 1.00 0.00 H ATOM 14406 H4'CYT 30-36.987-5. 952 1. 887 1.00 0.00 H ATOM 14407 H1'CYT 30-33.679-6. 056 1.943 1.00 0.00 H ATOM 14408 H6 CYT 30-34.997-7. 500 5.031 1.00 0.00 H ATOM 14409 1H4 CYT 30-31. 361-9. 444 7.152 1.00 0.00 H ATOM. 14410 2H4 CYT 30-30.053-9. 385 5.992 1.00 0. 00 H ATOM 14411 H5 CYT 30-33.568-8. 589 6.697 1.00 0.00 H ATOM 14412 H2'CYT 30-34.409-8. 684 1.647 1.00 0.00 H ATOM 14413 H02'CYT 30-34.267-7. 122-0.054 1.00 0.00 H ATOM 14414 H3'CYT 30-36.180-8. 560 3.235 1.00 0. 00 H ATOM 14415 H03'CYT 30-37.263-7. 964 0.651 1.00 0.00 H TER ATOM 14416 05'GUA 1 22.227-5. 255-0.787 1.00 0.00 0 ATOM 14417 C5'GUA 1 23.164-6. 001-1.571 1.00 0.00 C ATOM 14418 C4'GUA 1 22.965-7. 505-1.403 1.00 0.00 C ATOM 14419 04'GUA 1 23.105-7. 904-0.030 1.00 0.00 0 ATOM 14420 C1'GUA 1 22.002-8. 751 0. 340 1.00 0.00 C ATOM 14421 N9 GUA 1 21. 033-8.031 1. 189 1.00 0.00 N ATOM 14422 C4 GUA 1 20.033-8. 592 1.952 1.00 0.00 C ATOM 14423 N3 GUA 1 19.773-9. 914 2. 072 1.00 0.00 N ATOM 14424 C2 GUA 1 18.737-10. 153 2. 882 1. 00 0.00 C ATOM 14425 N2 GUA 1 18.344-11. 406 3.110 1. 00 0.00 N ATOM 14426 N1 GUA 1 18.020-9. 161 3.521 1. 00 0.00 N ATOM 14427 C6 GUA 1 18.267-7. 799 3.414 1.00 0.00 C ATOM 14428 06 GUA 1 17.564-6. 995 4.022 1.00 0.00 O

ATOM 14429 C5 GUA 1 19.366-7. 536 2.555 1.00 0.00 C ATOM 14430 N7 GUA 1 19.937-6. 316 2.180 1. 00 0.00 N ATOM 14431 C8 GUA 1 20.886-6. 699 1.395 1.00 0.00 C ATOM 14432 C2'GUA 1 21.361-9. 175-0.972 1.00 0.00 C ATOM 14433 02'GUA 1 22.031-10. 303-1.547 1.00 0.00 0 ATOM 14434 C3'GUA 1 21.555-7. 922-1.799 1.00 0.00 C ATOM 14435 03'GUA 1 21.551-8. 279-3.185 1.00 0.00 O ATOM 14436 H5'GUA 1 22.386-4. 325-0. 962 1.00 0.00 H ATOM 14437 1H5'GUA 1 24.175-5. 739-1.260 1.00 0.00 H ATOM 14438 2H5'GUA 1 23.035-5. 740-2.621 1.00 0.00 H ATOM 14439 H4'GUA 1 23.691-8. 043-2.011 1.00 0.00 H ATOM 14440 H1'GUA 1 22.374-9. 629 0.868 1.00 0.00 H ATOM 14441 1H2 GUA 1 18.830-12. 175 2.670 1.00 0.00 H ATOM 14442 2H2 GUA 1 17.561-11. 587 3.721 1.00 0.00 H ATOM 14443 Hl GUA 1 17.250-9. 424 4.116 1.00 0.00 H ATOM 14444 H8 GUA 1 21.544-5. 979 0.911 1.00 0.00 H ATOM 14445 H2'GUA 1 20.297-9. 378-0.826 1.00 0.00 H ATOM 14446 H02'GUA 1 21.812-11. 069-1. 011 1.00 0.00 H ATOM 14447 H3'GUA 1 20.816-7. 156-1.559 1.00 0.00 H ATOM 14448 P GUA 2 20.176-8. 278-4.024 1.00 0.00 P ATOM 14449 O1P GUA 2 19.509-6. 972-3.822 1.00 0.00 O ATOM 14450 02P GUA 2 20.470-8. 751-5.395 1.00 0.00 0 ATOM 14451 05'GUA 2 19.306-9. 408-3.275 1.00 0.00 0 ATOM 14452 C5'GUA 2 19.673-10. 787-3.369 1.00 0.00 C ATOM 14453 C4'GUA 2 18.840-11. 660-2.433 1.00 0.00 C ATOM 14454 04'GUA 2 18.971-11. 254-1.067 1.00 0.00 O ATOM 14455 Cl'GUA 2 17.705-11. 422-0.397 1.00 0.00 C ATOM 14456 N9 GUA 2 17.184-10. 134 0.106 1.00 0.00 N ATOM 14457 C4 GUA 2 16.153-9. 963 1.003 1.00 0.00 C ATOM 14458 N3 GUA 2 15.427-10. 952 1.573 1.00 0.00 N ATOM 14459 C2 GUA 2 14.494-10. 479 2.404 1.00 0.00 C ATOM 14460 N2 GUA 2 13.685-11. 321 3.046 1.00 0.00 N ATOM 14461 N1 GUA 2 14.299-9. 134 2.650 1.00 0.00 N ATOM 14462 C6 GUA 2 15.030-8. 102 2. 079 1.00 0.00 C ATOM 14463 06 GUA 2 14.779-6. 935 2.368 1.00 0.00 O ATOM 14464 C5 GUA 2 16.024-8. 596 1.192 1.00 0.00 C ATOM 14465 N7 GUA 2 16.962-7. 903 0.421 1.00 0.00 N ATOM 14466 C8 GUA 2 17.583-8. 867-0.170 1.00 0.00 C ATOM 14467 C2'GUA 2 16.755-12. 031-1.428 1.00 0.00 C ATOM 14468 02'GUA 2 16.755-13. 462-1.361 1.00 0.00 0 ATOM 14469 C3'GUA 2 17.357-11. 530-2.724 1.00 0.00 C ATOM 14470 03'GUA 2 17.012-12. 437-3.776 1.00 0.00 0 ATOM 14471 1H5'GUA 2 20.726-10. 894-3.109 1.00 0.00 H ATOM 14472 2H5'GUA 2 19.525-11. 125-4.395 1.00 0.00 H ATOM 14473 H4'GUA 2 19.144-12. 700-2.531 1.00 0.00 H ATOM 14474 Hl'GUA 2 17.826-12. 115 0.436 1.00 0.00 H ATOM 14475 1H2 GUA 2 13.777-12. 317 2.904 1.00 0.00 H ATOM 14476 2H2 GUA 2 12.979-10. 964 3.674 1.00 0.00 H ATOM 14477 H1 GUA 2 13.572-8. 857 3.295 1.00 0.00 H ATOM 14478 H8 GUA 2 18.397-8. 670-0.867 1.00 0.00 H ATOM 14479 H2'GUA 2 15.747-11. 630-1.296 1.00 0.00 H ATOM 14480 H02'GUA 2 16.257-13. 712-0.579 1.00 0.00 H ATOM 14481 H3'GUA 2 17.066-10. 501-2.940 1.00 0.00 H ATOM 14482 P CYT 3 15.602-12. 296-4.540 1.00 0.00 P ATOM 14483 01P CYT 3 15.547-13. 324-5.604 1.00 0.00 0 ATOM 14484 02P CYT 3 15.400-10. 870-4. 882 1.00 0.00 O ATOM 14485 05'CYT 3 14.542-12. 693-3.395 1.00 0.00 0 ATOM 14486 C5'CYT 3 14. 266-14. 066-3.101 1. 00 0.00 C ATOM 14487 C4'CYT 3 13.077-14. 208-2.155 1.00 0.00 C ATOM 14488 04'CYT 3 13.352-13. 650-0.861 1.00 0.00 0

ATOM 14489 C1'CYT 3 12.208-12. 895-0.414 1.00 0.00 C ATOM 14490 N1 CYT 3 12.487-11. 442-0.422 1.00 0.00 N ATOM 14491 C6 CYT 3 13.334-10. 897-1.342 1.00 0.00 C ATOM 14492 C2 CYT 3 11.855-10. 658 0.534 1.00 0.00 C ATOM 14493 02 CYT 3 11.089-11. 171 1.347 1.00 0.00 0 ATOM 14494 N3 CYT 3 12.103-9. 320 0.536 1.00 0.00 N ATOM 14495 C4 CYT 3 12.932-8. 772-0.362 1.00 0.00 C ATOM 14496 N4 CYT 3 13.157-7. 460-0.330 1.00 0.00 N ATOM 14497 C5 CYT 3 13.582-9. 577-1.350 1.00 0.00 C ATOM 14498 C2'CYT 3 11.087-13. 238-1.387 1.00 0.00 C ATOM 14499 02'CYT 3 10.399-14. 434-1.000 1.00 0.00 0 ATOM 14500 C3'CYT 3 11.875-13. 431-2.664 1.00 0.00 C ATOM 14501 03'CYT 3 11.127-14. 264-3.552 1.00 0.00 0 ATOM 14502 1H5'CYT 3 15.144-14. 517-2.640 1.00 0.00 H ATOM 14503 2H5'CYT 3 14.043-14. 589-4.031 1.00 0.00 H ATOM 14504 H4'CYT 3 12.816-15. 259-2.047 1.00 0.00 H ATOM 14505 Hl'CYT 3 11.930-13. 212 0.592 1.00 0.00 H ATOM 14506 H6 CYT 3 13.816-11. 539-2.080 1.00 0.00 H ATOM 14507 1H4 CYT 3 13.784-7. 038-1.000 1.00 0.00 H ATOM 14508 2H4 CYT 3 12.699-6. 886 0.364 1.00 0.00 H ATOM 14509 H5 CYT 3 14.247-9. 137-2.090 1.00 0.00 H ATOM 14510 H2'CYT 3 10.396-12. 397-1.485 1.00 0.00 H ATOM 14511 H02'CYT 3 11.057-15. 129-0.920 1.00 0.00 H ATOM 14512 H3'CYT 3 12.162-12. 477-3.114 1.00 0.00 H ATOM 14513 P GUA 4 10.179-13. 609-4.677 1.00 0.00 P ATOM 14514 01P GUA 4 9.515-14. 704-5.418 1.00 0.00 0 ATOM 14515 02P GUA 4 10.965-12. 592-5.411 1.00 0.00 0 ATOM 14516 05'GUA 4 9.067-12. 848-3.795 1.00 0.00 0 ATOM 14517 C5'GUA 4 8.151-13. 590-2.985 1.00 0.00 C ATOM 14518 C4'GUA 4 7.457-12. 701-1.956 1.00 0.00 C ATOM 14519 04'GUA 4 8.392-12. 030-1.110 1.00 0.00 O ATOM 14520 Cl'GUA 4 7'. 848-10.749-0. 731 1.00 0.00 C ATOM 14521 N9 GUA 4 8.752-9. 641-1.102 1.00 0.00 N ATOM 14522 C4 GUA 4 8.621-8. 325-0.721 1.00 0.00 C ATOM 14523 N3 GUA 4 7.641-7. 826 0.061 1.00 0.00 N ATOM 14524 C2 GUA 4 7.771-6. 513 0.260 1.00 0.00 C ATOM 14525 N2 GUA 4 6.880-5. 866 1.009 1.00 0.00 N ATOM 14526 N1 GUA 4 8.795-5. 754-0.276 1.00 0.00 N ATOM 14527 C6 GUA 4 9.815-6. 244-1.082 1.00 0.00 C ATOM 14528 06 GUA 4 10.686-5. 485-1.504 1.00 0.00 0 ATOM 14529 C5 GUA 4 9.681-7. 643-1.299 1.00 0.00 C ATOM 14530 N7 GUA 4 10.480-8. 518-2.042 1.00 0.00 N ATOM 14531 C8 GUA 4 9.869-9. 643-1.871 1.00 0.00 C ATOM 14532 C2'GUA 4 6.506-10. 620-1.454 1.00 0.00 C ATOM 14533 02'GUA 4 5.417-11. 014-0.611 1.00 0.00 0 ATOM 14534 C3'GUA 4 6. 688-11.576-2. 617 1.00 0.00 C ATOM 14535 03'GUA 4 5.405-12. 064-3.020 1.00 0.00 O ATOM 14536 1H5'GUA 4 8.695-14. 378-2.464 1.00 0.00 H ATOM 14537 2H5'GUA 4 7.397-14. 044-3.628 1.00 0.00 H ATOM 14538 H4'GUA 4 6.783-13. 299-1.345 1.00 0.00 H ATOM 14539 H1'GUA 4 7.680-10. 734 0.346 1.00 0.00 H ATOM 14540 1H2 GUA 4 6. 110-6.370 1.426 1.00 0.00 H ATOM 14541 2H2 GUA 4 6.972-4. 874 1.159 1.00 0.00 H ATOM 14542 H1 GUA 4 8.822-4. 763-0.082 1.00 0.00 H ATOM 14543 H8 GUA 4 10.236-10. 560-2.331 1.00 0.00 H ATOM 14544 H2'GUA 4 6.370-9. 599-1. 820 1.00 0.00 H ATOM 14545 H02'GUA 4 5.322-10. 340 0.066 1.00 0.00 H ATOM 14546 H3'GUA 4 7.246-11. 122-3.437 1.00 0.00 H ATOM 14547 P CYT 5 4.488-11. 204-4.027 1.00 0.00 P

ATOM 14548 01P CYT 5 3.268-11. 986-4.327 1.00 0. 00 0 ATOM 14549 02P CYT 5 5.344-10. 720-5.134 1.00 0. 00 O ATOM 14550 05'CYT 5 4.070-9. 937-3.125 1.00 0.00 O ATOM 14551 C5'CYT 5 2.985-10. 027-2.196 1.00 0.00 C ATOM 14552 C4'CYT 5 2.552-8. 648-1.706 1.00 0.00 C ATOM 14553 04'CYT 5 3.584-8. 005-0.946 1.00 0.00 0 ATOM 14554 Cl'CYT 5 3.670-6. 617-1.325 1.00 0.00 C ATOM 14555 N1 CYT 5 4.944-6. 331-2.022 1.00 0.00 N ATOM 14556 C6 CYT 5 5.518-7. 259-2.843 1.00 0.00 C ATOM 14557 C2 CYT 5 5.536-5. 092-1.807 1.00 0.00 C ATOM 14558 02 CYT 5 5.000-4. 269-1.065 1.00 0.00 O ATOM 14559 N3 CYT 5 6.712-4. 820-2.437 1.00 0.00 N ATOM 14560 C4 CYT 5 7.284-5. 723-3.244 1.00 0.00 C ATOM 14561 N4 CYT 5 8.437-5. 427-3.843 1.00 0.00 N ATOM 14562 C5 CYT 5 6.678-6. 998-3.469 1.00 0.00 C ATOM 14563 C2'CYT 5 2.471-6. 356-2.232 1.00 0.00 C ATOM 14564 02'CYT 5 1.317-5. 959-1.481 1.00 0.00 0 ATOM 14565 C3'CYT 5 2.282-7. 715-2.873 1.00 0.00 C ATOM 14566 03'CYT 5 0.915-7. 859-3.267 1.00 0.00 O ATOM 14567 1H5'CYT 5 3.294-10. 629-1.341 1.00 0.00 H ATOM 14568 2H5'CYT 5 2.139-10. 511-2.685 1.00 0.00 H ATOM 14569 H4'CYT 5 1.656-8. 740-1.094 1.00 0.00 H ATOM 14570 H1'CYT 5 3.593-5. 993-0.435 1.00 0.00 H ATOM 14571 H6 CYT 5 5.030-8. 223-2.992 1.00 0.00 H ATOM 14572 1H4 CYT 5 8.870-4. 529-3.689 1.00 0.00 H ATOM 14573 2H4 CYT 5 8.877-6. 102-4.452 1. 00 0.00 H ATOM 14574 H5 CYT 5 7.139-7. 732-4.128 1.00 0.00 H ATOM 14575 H2'CYT 5 2.726-5. 609-2.987 1.00 0.00 H ATOM 14576 H02'CYT 5 0.571-5. 956-2.085 1.00 0.00 H ATOM 14577 H3'CYT 5 2.977-7. 877-3.698 1.00 0.00 H ATOM 14578 P URI 6 0.497-7. 756-4.819 1.00 0.00 P ATOM 14579 01P URI 6 1.601-8. 309-5.636 1.00 0.00 O ATOM 14580 02P URI 6-0.873-8. 298-4.967 1.00 0.00 O ATOM 14581 05'URI 6 0.441-6. 165-5.058 1.00 0.00 O ATOM 14582 C5'URI 6-0.632-5. 389-4.518 1.00 0.00 C ATOM 14583 C4'URI 6-0.264-3. 913-4.406 1.00 0.00 C ATOM 14584 04'URI 6 0.910-3. 716-3.607 1.00 0.00 O ATOM 14585 C1'URI 6 1.702-2. 655-4.181 1.00 0.00 C ATOM 14586 Nl URI 6 3.016-3. 148-4.654 1.00 0.00 N ATOM 14587 C6 URI 6 3.160-4. 415-5.157 1.00 0.00 C ATOM 14588 C2 URI 6 4.090-2. 277-4.579 1.00 0. 00 C ATOM 14589 02 URI 6 3.979-1. 135-4.137 1.00 0.00 O ATOM 14590 N3 URI 6 5.300-2. 762-5.038 1.00 0.00 N ATOM 14591 C4 URI 6 5.530-4. 022-5.560 1.00 0.00 C ATOM 14592 04 URI 6 6.652-4. 346-5.941 1.00 0.00 O ATOM 14593 C5 URI 6 4.358-4. 866-5.602 1.00 0.00 C ATOM 14594 C2'URI 6 0.878-2. 097-5.337 1.00 0.00 C ATOM 14595 02'URI 6 0.014-1. 040-4.902 1.00 0.00 0 ATOM 14596 C3'URI 6 0.094-3. 321-5.757 1.00 0.00 C ATOM 14597 03'URI 6-1.106-2. 900-6.415 1.00 0.00 O ATOM 14598 1H5'URI 6-0.881-5. 768-3.526 1.00 0.00 H ATOM 14599 2H5'URI 6-1.503-5. 490-5.165 1.00 0.00 H ATOM 14600 H4'URI 6-1.093-3. 359-3.970 1.00 0.00 H ATOM 14601 Hl'URI 6 1.854-1. 873-3.437 1.00 0.00 H ATOM 14602 H6 URI 6 2.293-5. 075-5.196 1.00 0.00 H ATOM 14603 H3 URI 6 6.092-2. 137-4.987 1.00 0.00 H ATOM 14604 H5 URI 6 4.438-5. 877-6.002 1.00 0.00 H ATOM 14605 H2'URI 6 1.534-1. 765-6. 143 1.00 0.00 H ATOM 14606 H02'URI 6-0.522-1. 386-4.186 1.00 0.00 H

ATOM 14607 H3'URI 6 0.693-4. 004-6.362 1.00 0.00 H ATOM 14608 P CYT 7-1.124-2. 654-8. 009 1.00 0.00 P ATOM 14609 01P CYT 7-0.330-3. 724-8.653 1.00 0.00 0 ATOM 14610 02P CYT 7-2.526-2. 423-8.425 1.00 0.00 0 ATOM 14611 05'CYT 7-0.317-1. 268-8.163 1.00 0. 00 0 ATOM 14612 C5'CYT 7-0. 823-0. 064-7. 579 1.00 0.00 C ATOM 14613 C4'CYT 7 0.270 0.991-7. 418 1.00 0.00 C ATOM 14614 04'CYT 7 1. 421 0.458-6. 756 1.00 0.00 0 ATOM 14615 C1'CYT 7 2.612 1.040-7. 322 1.00 0.00 C ATOM 14616 N1 CYT 7 3.489 0.017-7. 934 1.00 0.00 N ATOM 14617 C6 CYT 7 3.035-1. 245-8.198 1.00 0.00 C ATOM 14618 C2 CYT 7 4.790 0.395-8. 234 1.00 0.00 C ATOM 14619 02 CYT 7 5.174 1.536-7. 987 1.00 0.00 0 ATOM 14620 N3 CYT 7 5.614-0. 523-8. 804 1.00 0.00 N ATOM 14621 C4 CYT 7 5.185-1. 762-9.069 1.00 0.00 C ATOM 14622 N4 CYT 7 6.023-2. 632-9.631 1. 00 0.00 N ATOM 14623 C5 CYT 7 3.846-2. 160-8.761 1.00 0.00 C ATOM 14624 C2'CYT 7 2.138 2.046-8. 367 1.00 0.00 C ATOM 14625 02'CYT 7 2.009 3.357-7. 804 1.00 0.00 O ATOM 14626 C3'CYT 7 0.792 1.471-8. 761 1.00 0.00 C ATOM 14627 03'CYT 7-0.041 2.539-9. 226 1.00 0.00 O ATOM 14628 1H5'CYT 7-1.240-0. 293-6.598 1.00 0.00 H ATOM 14629 2H5'CYT 7-1.613 0.337-8. 216 1.00 0.00 H ATOM 14630 H4'CYT 7-0.114 1.836-6. 849 1.00 0.00 H ATOM 14631 Hl'CYT 7 3.160 1.566-6. 542 1.00 0.00 H ATOM 14632 H6 CYT 7 2.008-1. 512-7.953 1.00 0.00 H ATOM 14633 1H4 CYT 7 5.713-3. 571-9. 838 1. 00 0.00 H ATOM 14634 2H4 CYT 7 6.967-2. 350-9.854 1.00 0.00 H ATOM 14635 H5 CYT 7 3.494-3. 170-8.975 1.00 0.00 H ATOM 14636 H2'CYT 7 2.817 2.050-9. 224 1.00 0.00 H ATOM 14637 H02'CYT 7 2.895 3.677-7. 621 1.00 0.00 H ATOM 14638 H3'CYT 7 0. 887 0.659-9. 483 1.00 0.00 H ATOM 14639 P ADE 8-0. 013 2. 996-10. 773 1.00 0.00 P ATOM 14640 01P ADE 8-0.248 1.800-11. 613 1.00 0.00 0 ATOM 14641 02P ADE 8-0.887 4. 182-10. 920 1.00 0.00 0 ATOM 14642 05'ADE 8 1.515 3.464-10. 985 1.00 0.00 0 ATOM 14643 C5'ADE 8 2. 056 4.563-10. 244 1.00 0.00 C ATOM 14644 C4'ADE 8 3.571 4.670-10. 418 1.00 0.00 C ATOM 14645 04'ADE 8 4.223 3.418-10. 140 1.00 0.00 0 ATOM 14646 C1'ADE 8 5.129 3.098-11. 213 1.00 0.00 C ATOM 14647 N9 ADE 8 4.572 2. 052-12. 094 1.00 0. 00 N ATOM 14648 C4 ADE 8 5.245 1.338-13. 065 1.00 0.00 C ATOM 14649 N3 ADE 8 6.552 1.446-13. 385 1.00 0.00 N ATOM 14650 C2 ADE 8 6.880 0.612-14. 371 1.00 0.00 C ATOM 14651 N1 ADE 8 6.076-0. 244-15.002 1.00 0.00 N ATOM 14652 C6 ADE 8 4.778-0. 334-14.666 1.00 0.00 C ATOM 14653 N6 ADE 8 3.992-1. 192-15.314 1.00 0.00 N ATOM 14654 C5 ADE 8 4.318 0.498-13. 639 1.00 0.00 C ATOM 14655 N7 ADE 8 3.062 0.663-13. 048 1.00 0.00 N ATOM 14656 C8 ADE 8 3.306 1.577-12. 171 1.00 0.00 C ATOM 14657 C2'ADE 8 5.325 4.397-11. 972 1.00 0.00 C ATOM 14658 02'ADE 8 6.324 5.221-11. 357 1.00 0.00 0 ATOM 14659 C3'ADE 8 3.942 5.004-11. 858 1.00 0.00 C ATOM 14660 03'ADE 8 4.055 6.426-11. 992 1.00 0. 00 0 ATOM 14661 1H5'ADE 8 1.830 4.425-9. 187 1.00 0.00 H ATOM 14662 2H5'ADE 8 1.592 5. 488-10. 587 1.00 0.00 H ATOM 14663 H4'ADE 8 3.964 5.436-9. 752 1.00 0.00 H ATOM 14664 H1'ADE 8 6. 080 2.765-10. 802 1.00 0.00 H ATOM 14665 H2 ADE 8 7.921 0.630-14. 701 1.00 0.00 H ATOM 14666 1H6 ADE 8 4.373-1. 771-16.049 1.00 0.00 H

ATOM 14667 2H6 ADE 8 3.014-1. 262-15.072 1.00 0.00 H ATOM 14668 H8 ADE 8 2.522 1.960-11. 519 1.00 0.00 H ATOM 14669 H2'ADE 8 5.569 4.191-13. 016 1.00 0.00 H ATOM 14670 H02'ADE 8 7.171 4.791-11. 492 1.00 0.00 H ATOM 14671 H3'ADE 8 3.245 4.567-12. 574 1.00 0.00 H ATOM 14672 P ADE 9 2.796 7.314-12. 465 1.00 0.00 P ATOM 14673 01P ADE 9 3.279 8.683-12. 751 1.00 0.00 0 ATOM 14674 02P ADE 9 1.691 7.109-11. 502 1.00 0.00 0 ATOM 14675 05'ADE 9 2.382 6.625-13. 862 1.00 0.00 0 ATOM 14676 C5'ADE 9 1.488 7.289-14. 762 1.00 0.00 C ATOM 14677 C4'ADE 9 1.213 6.455-16. 015 1.00 0.00 C ATOM 14678 04'ADE 9 2.428 6.101-16. 683 1.00 0.00 0 ATOM 14679 C1'ADE 9 2.701 4.702-16. 496 1.00 0.00 C ATOM 14680 N9 ADE 9 4.099 4.497-16. 077 1.00 0.00 N ATOM 14681 C4 ADE 9 5.032 3.686-16. 679 1.00 0.00 C ATOM 14682 N3 ADE 9 4.836 2.912-17. 762 1.00 0.00 N ATOM 14683 C2 ADE 9 5.942 2.254-18. 089 1.00 0.00 C ATOM 14684 N1 ADE 9 7.124 2.303-17. 474 1.00 0.00 N ATOM 14685 C6 ADE 9 7.296 3.084-16. 394 1.00 0.00 C ATOM 14686 N6 ADE 9 8.485 3.118-15. 792 1.00 0.00 N ATOM 14687 C5 ADE 9 6.195 3.827-15. 957 1.00 0.00 C ATOM 14688 N7 ADE 9 6.015 4.720-14. 898 1.00 0.00 N ATOM 14689 C8 ADE 9 4.777 5.053-15. 049 1.00 0.00 C ATOM 14690 C2'ADE 9 1.728 4.223-15. 424 1.00 0.00 C ATOM 14691 02'ADE 9 1.388 2.843-15. 598 1.00 0.00 0 ATOM 14692 C3'ADE 9 0.539 5.129-15. 671 1.00 0.00 C ATOM 14693 03'ADE 9-0.163 4.630-16. 826 1.00 0.00 0 ATOM 14694 1H5'ADE 9 1.929 8.240-15. 061 1.00 0.00 H ATOM 14695 2H5'ADE 9 0.545 7.481-14. 250 1.00 0.00 H ATOM 14696 H4'ADE 9 0.585 7.026-16. 694 1.00 0.00 H ATOM 14697 H1'ADE 9 2.514 4.164-17. 426 1.00 0.00 H ATOM 14698 H2 ADE 9 5.877 1.608-18. 960 1.00 0.00 H ATOM 14699 1H6 ADE 9 8.623 3.700-14. 979 1.00 0.00 H ATOM 14700 2H6 ADE 9 9.248 2.561-16. 150 1.00 0.00 H ATOM 14701 H8 ADE 9 4.293 5.752-14. 370 1.00 0.00 H ATOM 14702 H2'ADE 9 2.140 4.408-14. 428 1.00 0.00 H ATOM 14703 H02'ADE 9 1.005 2.753-16. 474 1.00 0.00 H ATOM 14704 H3'ADE 9-0.105 5.209-14. 794 1.00 0.00 H ATOM 14705 P URI 10-1.100 5.583-17. 732 1.00 0.00 P ATOM 14706 OlP URI 10-1.866 4.729-18. 665 1.00 0.00 0 ATOM 14707 02P URI 10-1. 811 6.525-16. 838 1.00 0.00 0 ATOM 14708 05'URI 10-0. 011 6.415-18. 581 1.00 0.00 0 ATOM 14709 C5'URI 10-0.289 6.865-19. 910 1.00 0. 00 C ATOM 14710 C4'URI 10 0.701 6.271-20. 909 1.00 0.00 C ATOM 14711 04'URI 10 0.538 4.848-21. 024 1.00 0.00 0 ATOM 14712 Cl'URI 10 0.052 4.519-22. 338 1.00 0.00 C ATOM 14713 N1 URI 10-1.000 3.478-22. 280 1.00 0.00 N ATOM 14714 C6 URI 10-1.578 3.125-21. 089 1.00 0.00 C ATOM 14715 C2 URI 10-1.382 2.881-23. 470 1.00 0.00 C ATOM 14716 02 URI 10-0.872 3.178-24. 549 1.00 0.00 0 ATOM 14717 N3 URI 10-2.372 1.920-23. 378 1.00 0.00 N ATOM 14718 C4 URI 10-3.006 1.508-22. 218 1.00 0.00 C ATOM 14719 04 URI 10-3.876 0.642-22. 255 1.00 0.00 0 ATOM 14720 C5 URI 10-2.546 2.181-21. 026 1.00 0.00 C ATOM 14721 C2'URI 10-0.490 5.823-22. 907 1.00 0.00 C ATOM 14722 02'URI 10-0.453 5.838-24. 338 1.00 0.00 0 ATOM 14723 C3'URI 10 0.480 6.824-22. 311 1.00 0.00 C ATOM 14724 03'URI 10 1.718 6.738-23. 030 1.00 0.00 0 ATOM 14725 1H5'URI 10-0.213 7.952-19. 938 1.00 0.00 H ATOM 14726 2H5'URI 10-1.302 6.573-20. 188 1.00 0.00 H

ATOM 14727 H4'URI 10 1.715 6.490-20. 587 1.00 0.00 H ATOM 14728 H1'URI 10 0.880 4.169-22. 957 1.00 0.00 H ATOM 14729 H6 URI 10-1.246 3. 608-20. 170 1.00 0.00 H ATOM 14730 H3 URI 10-2.660 1. 476-24. 238 1.00 0.00 H ATOM 14731 H5 URI 10-2.986 1.929-20. 062 1.00 0.00 H ATOM 14732 H2'URI 10-1.501 6.010-22. 532 1.00 0.00 H ATOM 14733 H02'URI 10-0.530 6.754-24. 616 1.00 0.00 H ATOM 14734 H3'URI 10 0.075 7.836-22. 297 1.00 0.00 H ATOM 14735 P GUA 11 2.864 7.859-22. 854 1.00 0.00 P ATOM 14736 01P GUA 11 4.026 7.463-23. 680 1.00 0.00 0 ATOM 14737 02P GUA 11 2.244 9.190-23. 046 1.00 0.00 0 ATOM 14738 05'GUA 11 3.279 7.709-21. 302 1.00 0.00 0 ATOM 14739 C5'GUA 11 3.021 8.762-20. 365 1.00 0.00 C ATOM 14740 C4'GUA 11 3.953 8.682-19. 156 1.00 0.00 C ATOM 14741 04'GUA 11 3.817 7.429-18. 463 1.00 0.00 0 ATOM 14742 C1'GUA 11 5.114 6. 825-18. 315 1.00 0.00 C ATOM 14743 N9 GUA 11 5.330 5.789-19. 338 1.00 0.00 N ATOM 14744 C4 GUA 11 6.479 5.067-19. 547 1.00 0.00 C ATOM 14745 N3 GUA 11 7.623 5.176-18. 837 1.00 0.00 N ATOM 14746 C2 GUA 11 8.569 4.342-19. 275 1.00 0.00 C ATOM 14747 N2 GUA 11 9.762 4.322-18. 684 1.00 0.00 N ATOM 14748 Nl GUA 11 8.392 3.470-20. 332 1.00 0.00 N ATOM 14749 C6 GUA 11 7.226 3.342-21. 075 1.00 0.00 C ATOM 14750 06 GUA 11 7.169 2.540-22. 003 1.00 0.00 O ATOM 14751 C5 GUA 11 6.217 4.224-20. 616 1.00 0.00 C ATOM 14752 N7 GUA 11 4.913 4. 411-21. 080 1.00 0.00 N ATOM 14753 C8 GUA 11 4.483 5.329-20. 284 1.00 0.00 C ATOM 14754 C2'GUA 11 6.097 7.970-18. 480 1.00 0.00 C ATOM 14755 02'GUA 11 6.216 8.742-17. 278 1.00 0.00 0 ATOM 14756 C3'GUA 11 5.414 8.749-19. 583 1.00 0.00 C ATOM 14757 03'GUA 11 5.847 10.110-19. 527 1.00 0.00 0 ATOM 14758 1H5'GUA 11 1.989 8.690-20. 022 1.00 0.00 H ATOM 14759 2H5'GUA 11 3.165 9.723-20. 860 1.00 0.00 H ATOM 14760 H4'GUA 11 3.734 9.498-18. 470 1.00 0.00 H ATOM 14761 H1'GUA 11 5.211 6.387-17. 321 1.00 0.00 H ATOM 14762 1H2 GUA 11 10.479 3.691-19. 014 1.00 0.00 H ATOM 14763 2H2 GUA 11 9.950 4.938-17. 906 1.00 0.00 H ATOM 14764 H1 GUA 11 9.158 2.871-20. 602 1.00 0.00 H ATOM 14765 H8 GUA 11 3.476 5.727-20. 371 1.00 0. 00 H ATOM 14766 H2'GUA 11 7.069 7.597-18. 813 1.00 0.00 H ATOM 14767 H02'GUA 11 5.334 9.033-17. 038 1.00 0.00 H ATOM 14768 H3'GUA 11 5.577 8.295-20. 563 1.00 0.00 H ATOM 14769 P CYT 12 6.762 10.717-20. 703 1.00 0.00 P ATOM 14770 O1P CYT 12 6.162 10.334-22. 001 1.00 0.00 O ATOM 14771 02P CYT 12 7.018 12.143-20. 401 1.00 0.00 0 ATOM 14772 05'CYT 12 8.140 9.904-20. 525 1.00 0.00 0 ATOM 14773 C5'CYT 12 8.992 10.161-19. 406 1.00 0.00 C ATOM 14774 C4'CYT 12 10.197 9.225-19. 387 1.00 0.00 C ATOM 14775 04'CYT 12 9.804 7.852-19. 276 1.00 0.00 0 ATOM 14776 C1'CYT 12 10.629 7.046-20. 141 1.00 0.00 C ATOM 14777 N1 CYT 12 9.836 6.457-21. 247 1.00 0.00 N ATOM 14778 C6 CYT 12 8.554 6. 863-21. 488 1.00 0.00 C ATOM 14779 C2 CYT 12 10.430 5.453-22. 004 1.00 0.00 C ATOM 14780 02 CYT 12 11.594 5.118-21. 788 1.00 0. 00 0 ATOM 14781 N3 CYT 12 9.696 4.871-22. 992 1.00 0.00 N ATOM 14782 C4 CYT 12 8.436 5.256-23. 232 1.00 0.00 C ATOM 14783 N4 CYT 12 7.737 4.646-24. 188 1.00 0.00 N ATOM 14784 C5 CYT 12 7.824 6. 294-22.464 1. 00 0.00 C ATOM 14785 C2'CYT 12 11.714 7.978-20. 668 1.00 0.00 C ATOM 14786 02'CYT 12 12.846 8.014-19. 791 1.00 0. 00 0

ATOM 14787 C3'CYT 12 10.977 9.300-20. 687 1.00 0.00 C ATOM 14788 03'CYT 12 11.927 10.365-20. 591 1.00 0.00 0 ATOM 14789 1H5'CYT 12 8.423 10.026-18. 486 1.00 0.00 H ATOM 14790 2H5'CYT 12 9.345 11.191-19. 458 1.00 0.00 H ATOM 14791 H4'CYT 12 10.849 9.482-18. 553 1.00 0.00 H ATOM 14792 H1'CYT 12 11.090 6.248-19. 559 1.00 0.00 H ATOM 14793 H6 CYT 12 8.118 7.659-20. 885 1.00 0.00 H ATOM 14794 1H4 CYT 12 6.781 4.919-24. 366 1.00 0.00 H ATOM 14795 2H4 CYT 12 8.159 3.905-24. 728 1.00 0.00 H ATOM 14796 H5 CYT 12 6.801 6.614-22. 663 1.00 0.00 H ATOM 14797 H2'CYT 12 12.005 7.685-21. 677 1.00 0.00 H ATOM 14798 H02'CYT 12 12.514 8.159-18. 902 1.00 0.00 H ATOM 14799 H3'CYT 12 10. 324 9.392-21. 557 1.00 0.00 H ATOM 14800 P URI 13 12.439 11.124-21. 915 1.00 0.00 P ATOM 14801 01P URI 13 13.250 12.290-21. 498 1.00 0.00 0 ATOM 14802 02P URI 13 11.280 11.316-22. 817 1.00 0. 00 0 ATOM 14803 05'URI 13 13.420 10.036-22. 582 1.00 0.00 0 ATOM 14804 C5'URI 13 14.665 9.703-21. 962 1.00 0.00 C ATOM 14805 C4'URI 13 15.290 8.463-22. 593 1.00 0.00 C ATOM 14806 04'URI 13 14.430 7. 322-22. 482 1.00 0.00 0 ATOM 14807 C1'URI 13 14.473 6.566-23. 708 1.00 0.00 C ATOM 14808 N1 URI 13 13.162 6.579-24. 400 1.00 0.00 N ATOM 14809 C6 URI 13 12.223 7.539-24. 124 1.00 0.00 C ATOM 14810 C2 URI 13 12.912 5.569-25. 314 1.00 0.00 C ATOM 14811 02 URI 13 13.745 4.708-25. 586 1.00 0.00 O ATOM 14812 N3 URI 13 11.667 5.589-25. 915 1.00 0.00 N ATOM 14813 C4 URI 13 10.665 6.516-25. 688 1.00 0.00 C ATOM 14814 04 URI 13 9.586 6.426-26. 266 1.00 0.00 0 ATOM 14815 C5 URI 13 11.012 7.536-24. 727 1.00 0.00 C ATOM 14816 C2'URI 13 15.557 7.213-24. 564 1.00 0.00 C ATOM 14817 02'URI 13 16.840 6.627-24. 314 1.00 0.00 0 ATOM 14818 C3'URI 13 15.497 8.649-24. 085 1.00 0.00 C ATOM 14819 03'URI 13 16.772 9.263-24. 298 1.00 0.00 O ATOM 14820 1H5'URI 13 14.497 9.516-20. 901 1.00 0.00 H ATOM 14821 2H5'URI 13 15.352 10.543-22. 071 1.00 0.00 H ATOM 14822 H4'URI 13 16.243 8.245-22. 114 1.00 0.00 H ATOM 14823 H1'URI 13 14.755 5.536-23. 486 1.00 0.00 H ATOM 14824 H6 URI 13 12.457 8.327-23. 409 1. 00 0. 00 H ATOM 14825 H3 URI 13 11.472 4.858-26. 583 1.00 0.00 H ATOM 14826 H5 URI 13 10. 288 8.314-24. 483 1.00 0.00 H ATOM 14827 H2'URI 13 15.294 7.150-25. 621 1.00 0.00 H ATOM 14828 H02'URI 13 17.502 7.294-24. 507 1. 00 0. 00 H ATOM 14829 H3'URI 13 14.679 9.201-24. 550 1.00 0.00 H ATOM 14830 P CYT 14 17.062 10.100-25. 643 1.00 0.00 P ATOM 14831 O1P CYT 14 18. 380 10.758-25. 505 1.00 0.00 0 ATOM 14832 02P CYT 14 15.862 10.909-25. 954 1.00 0.00 0 ATOM 14833 05'CYT 14 17.189 8.942-26. 755 1.00 0.00 O ATOM 14834 C5'CYT 14 18.337 8.089-26. 792 1.00 0. 00 C ATOM 14835 C4'CYT 14 18.132 6.918-27. 748 1.00 0.00 C ATOM 14836 04'CYT 14 16.989 6.138-27. 385 1.00 0.00 O ATOM 14837 C1'CYT 14 16.272 5.744-28. 570 1.00 0.00 C ATOM 14838 N1 CYT 14 14.912 6.327-28. 600 1.00 0.00 N ATOM 14839 C6 CYT 14 14.641 7.517-27. 989 1.00 0.00 C ATOM 14840 C2 CYT 14 13.926 5.617-29. 273 1.00 0.00 C ATOM 14841 02 CYT 14 14.196 4.552-29. 825 1. 00 0.00 0 ATOM 14842 N3 CYT 14 12.669 6.135-29. 308 1.00 0.00 N ATOM 14843 C4 CYT 14 12. 390 7.300-28. 712 1.00 0.00 C ATOM 14844 N4 CYT 14 11.147 7.776-28. 763 1.00 0.00 N ATOM 14845 C5 CYT 14 13.402 8.036-28. 021 1.00 0.00 C ATOM 14846 C2'CYT 14 17.100 6.230-29. 755 1.00 0.00 C

ATOM 14847 02'CYT 14 17.998 5.215-30. 219 1.00 0. 00 0 ATOM 14848 C3'CYT 14 17.846 7.406-29. 157 1.00 0.00 C ATOM 14849 03'CYT 14 19.091 7.558-29. 846 1.00 0.00 0 ATOM 14850 1H5'CYT 14 18.528 7. 702-25.792 1.00 0. 00 H ATOM 14851 2H5'CYT 14 19.200 8.669-27. 121 1.00 0.00 H ATOM 14852 H4'CYT 14 19.017 6.284-27. 751 1.00 0.00 H ATOM 14853 H1'CYT 14 16.200 4.657-28. 604 1.00 0.00 H ATOM 14854 H6 CYT 14 15.435 8.050-27. 466 1.00 0.00 H ATOM 14855 1H4 CYT 14 10.922 8.652-28. 314 1.00 0.00 H ATOM 14856 2H4 CYT 14 10.430 7.261-29. 254 1.00 0.00 H ATOM 14857 H5 CYT 14 13.180 8.989-27. 545 1.00 0.00 H ATOM 14858 H2'CYT 14 16.440 6.569-30. 558 1.00 0.00 H ATOM 14859 H02'CYT 14 18.520 4.929-29. 466 1.00 0.00 H ATOM 14860 H3'CYT 14 17.246 8.318-29. 164 1.00 0.00 H ATOM 14861 P URI 15 19.208 8.532-31. 122 1.00 0.00 P ATOM 14862 01P URI 15 18.733 9.877-30. 724 1.00 0.00 0 ATOM 14863 02P URI 15 20.558 8.370-31. 707 1.00 0.00 0 ATOM 14864 05'URI 15 18.135 7.902-32. 145 1.00 0.00 0 ATOM 14865 C5'URI 15 18.409 6.675-32. 827 1.00 0.00 C ATOM 14866 C4'URI 15 17. 169 6.143-33. 542 1.00 0.00 C ATOM 14867 04'URI 15 16.109 5.852-32. 618 1.00 0.00 0 ATOM 14868 C1'URI 15 14.867 6.372-33. 130 1.00 0.00 C ATOM 14869 N1 URI 15 14.412 7.547-32. 349 1.00 0.00 N ATOM 14870 C6 URI 15 15.309 8.460-31. 863 1.00 0.00 C ATOM 14871 C2 URI 15 13.052 7.692-32. 141 1.00 0.00 C ATOM 14872 02 URI 15 12.232 6. 881-32. 564 1.00 0.00 0 ATOM 14873 N3 URI 15 12.663 8.807-31. 422 1.00 0.00 N ATOM 14874 C4 URI 15 13.502 9.775-30. 900 1.00 0.00 C ATOM 14875 04 URI 15 13. 044 10.728-30. 275 1.00 0.00 0 ATOM 14876 C5 URI 15 14.903 9.544-31. 163 1.00 0.00 C ATOM 14877 C2'URI 15 15.146 6.752-34. 579 1.00 0.00 C ATOM 14878 02'URI 15 14.978 5.635-35. 461 1.00 0.00 0 ATOM 14879 C3'URI 15 16.595 7.182-34. 492 1. 00 0.00 C ATOM 14880 03'URI 15 17.205 7.016-35. 775 1.00 0.00 0 ATOM 14881 1H5'URI 15 18.749 5.932-32. 105 1.00 0.00 H ATOM 14882 2H5'URI 15 19.197 6.845-33. 561 1.00 0.00 H ATOM 14883 H4'URI 15 17.423 5.240-34. 097 1.00 0.00 H ATOM 14884 H1'URI 15 14.105 5.593-33. 097 1.00 0.00 H ATOM 14885 H6 URI 15 16.374 8.308-32. 038 1.00 0.00 H ATOM 14886 H3 URI 15 11.673 8.926-31. 264 1.00 0.00 H ATOM 14887 H5 URI 15 15.644 10.253-30. 797 1.00 0.00 H ATOM 14888 H2'URI 15 14. 514 7.592-34. 880 1.00 0.00 H ATOM 14889 H02'URI 15 15.511 4.916-35. 115 1.00 0.00 H ATOM 14890 H3'URI 15 16.698 8.198-34. 103 1.00 0.00 H ATOM 14891 P URI 16 17.147 8.199-36. 864 1.00 0.00 P ATOM 14892 O1P URI 16 17.960 7.793-38. 032 1.00 0.00 0 ATOM 14893 02P URI 16 17.431 9.478-36. 175 1.00 0.00 0 ATOM 14894 05'URI 16 15.596 8.196-37. 302 1.00 0.00 0 ATOM 14895 C5'URI 16 15.105 9.145-38. 254 1.00 0.00 C ATOM 14896 C4'URI 16 14.530 8.453-39. 484 1. 00 0.00 C ATOM 14897 04'URI 16 15.460 7.505-40. 029 1.00 0.00 0 ATOM 14898 C1'URI 16 14.849 6.212-40. 100 1.00 0.00 C ATOM 14899 N1 URI 16 15.834 5.142-39. 826 1.00 0.00 N ATOM 14900 C6 URI 16 16.454 5.048-38. 607 1.00 0.00 C ATOM 14901 C2 URI 16 16.106 4.244-40. 844 1.00 0.00 C ATOM 14902 02 URI 16 15.560 4.312-41. 944 1.00 0. 00 0 ATOM 14903 N3 URI 16 17.033 3.260-40. 554 1.00 0.00 N ATOM 14904 C4 URI 16 17.702 3.095-39. 353 1.00 0.00 C ATOM 14905 04 URI 16 18.509 2.180-39. 207 1.00 0.00 0 ATOM 14906 C5 URI 16 17.358 4.074-38. 348 1.00 0.00 C

ATOM 14907 C2'URI 16 13. 745 6. 228 - 39. 056 1. 00 0. 00 C ATOM 14908 02'URI 16 12. 698 5. 305-39. 379 1. 00 0. 00 0 ATOM 14909 C3'URI 16 13. 268 7. 667-39. 130 1. 00 0. 00 C ATOM 14910 03'URI 16 12. 345 7. 795-40. 216 1. 00 0. 00 0 ATOM 14911 1H5'URI 16 15. 916 9. 800-38. 558 1. 00 0. 00 H ATOM 14912 2H5'URI 16 14. 325 9. 746-37. 792 1. 00 0. 00 H ATOM 14913 H4'URI 16 14. 293 9. 199-40. 241 1. 00 0. 00 H ATOM 14914 H1' URI 16 14. 413 6. 068-41. 090 1. 00 0. 00 H ATOM 14915 H6 URI 16 16. 214 5. 772-37. 829 1. 00 0. 00 H ATOM 14916 H3 URI 16 17. 241 2. 598-41. 287 1. 00 0. 00 H ATOM 14917 H5 URI 16 17. 832 4. 027-37. 367 1. 00 0. 00 H ATOM 14918 H2'URI 16 14. 158 6. 023-38. 064 1. 00 0. 00 H ATOM 14919 H02'URI 16 13. 058 4. 420-39. 285 1. 00 0. 00 H ATOM 14920 H3'URI 16 12. 834 8. 000-38. 187 1. 00 0. 00 H ATOM 14921 P CYT 17 11. 497 9. 152-40. 399 1. 00 0. 00 P ATOM 14922 01P CYT 17 12. 438 10. 251-40. 709 1. 00 0. 00 0 ATOM 14923 02P CYT 17 10. 365 8. 871-41. 311 1. 00 0. 00 O ATOM 14924 05'CYT 17 10. 908 9. 393-38. 920 1. 00 0. 00 0 ATOM 14925 C5'CYT 17 9. 945 8. 490-38. 371 1. 00 0. 00 C ATOM 14926 C4'CYT 17 9. 529 8. 884-36. 959 1. 00 0. 00 C ATOM 14927 04'CYT 17 10. 640 8. 846-36. 051 1. 00 0. 00 0 ATOM 14928 C1'CYT 17 10. 707 10. 087-35. 347 1. 00 0. 00 C ATOM 14929 Nl CYT 17 12. 091 10. 414-34. 952 1. 00 0. 00 N ATOM 14930 C6 CYT 17 13. 146 9. 891-35. 631 1. 00 0. 00 C ATOM 14931 C2 CYT 17 12. 274 11. 261-33. 867 1. 00 0. 00 C ATOM 14932 02 CYT 17 11. 303 11. 721-33. 268 1. 00 0. 00 0 ATOM 14933 N3 CYT 17 13. 548 11. 562-33. 492 1. 00 0. 00 N ATOM 14934 C4 CYT 17 14. 596 11. 053-34. 154 1. 00 0. 00 C ATOM 14935 N4 CYT 17 15. 832 11. 364-33. 761 1. 00 0. 00 N ATOM 14936 C5 CYT 17 14. 406 10. 182-35. 270 1. 00 0. 00 C ATOM 14937 C2'CYT 17 10. 147 11. 103-36. 321 1. 00 0. 00 C ATOM 14938 02'CYT 17 9. 691 12. 287-35. 655 1. 00 0. 00 0 ATOM 14939 C3'CYT 17 8. 995 10. 315-36. 926 1. 00 0. 00 C ATOM 14940 03'CYT 17 7. 886 10. 358-36. 019 1. 00 0. 00 0 ATOM 14941 1H5' CYT 17 10. 370 7. 491-38. 346 1. 00 0. 00 H ATOM 14942 2H5'CYT 17 9. 066 8. 484-39. 009 1. 00 0. 00 H ATOM 14943 H4'CYT 17 8. 756 8. 203-36. 608 1. 00 0. 00 H ATOM 14944 H1' CYT 17 10. 076 10. 039-34. 465 1. 00 0. 00 H ATOM 14945 H6 CYT 17 12. 965 9. 228-36. 476 1. 00 0. 00 H ATOM 14946 1H4 CYT 17 16. 628 10. 984-34. 253 1. 00 0. 00 H ATOM 14947 2H4 CYT 17 15. 971 11. 979-32. 973 1. 00 0. 00 H ATOM 14948 H5 CYT 17 15. 252 9. 769-35. 813 1. 00 0. 00 H ATOM 14949 H2'CYT 17 10. 889 11. 338-37. 090 1. 00 0. 00 H ATOM 14950 H02'CYT 17 10. 459 12. 703-35. 254 1. 00 0. 00 H ATOM 14951 H3'CYT 17 8. 732 10. 669-37. 922 1. 00 0. 00 H ATOM 14952 P GUA 18 6. 372 10. 442-36. 566 1. 00 0. 00 P ATOM 14953 O1P GUA 18 6. 308 11. 509-37. 590 1. 00 0. 00 0 ATOM 14954 02P GUA 18 5. 461 10. 485-35. 400 1. 00 0. 00 0 ATOM 14955 05'GUA 18 6. 179 9. 023-37. 306 1. 00 0. 00 0 ATOM 14956 C5'GUA 18 6. 020 7. 816-36. 552 1. 00 0. 00 C ATOM 14957 C4'GUA 18 5. 928 6. 597-37. 467 1. 00 0. 00 C ATOM 14958 04'GUA 18 7. 101 6. 466-38. 279 1. 00 0. 00 0 ATOM 14959 C1' GUA 18 7. 477 5. 080-38. 369 1. 00 0. 00 C ATOM 14960 N9 GUA 18 8. 788 4. 836-37. 734 1. 00 0. 00 N ATOM 14961 C4 GUA 18 9. 258 5. 394-36. 564 1. 00 0. 00 C ATOM 14962 N3 GUA 18 8. 595 6. 274-35. 781 1. 00 0. 00 N ATOM 14963 C2 GUA 18 9. 309 6. 639-34. 713 1. 00 0. 00 C ATOM 14964 N2 GUA 18 8. 804 7. 510-33. 840 1. 00 0. 00 N ATOM 14965 N1 GUA 18 10. 578 6. 168-34. 444 1. 00 0. 00 N ATOM 14966 C6 GUA 18 11. 279 5. 264-35. 230 1. 00 0. 00 C

ATOM 14967 06 GUA 18 12.405 4.903-34. 898 1.00 0.00 0 ATOM 14968 C5 GUA 18 10.528 4.872-36. 369 1.00 0.00 C ATOM 14969 N7 GUA 18 10.863 3.991-37. 401 1.00 0.00 N ATOM 14970 C8 GUA 18 9.804 4.033-38. 137 1.00 0.00 C ATOM 14971 C2'GUA 18 6.371 4.291-37. 671 1.00 0.00 C ATOM 14972 02'GUA 18 5.350 3.891-38. 594 1.00 0.00 0 ATOM 14973 C3'GUA 18 5.853 5.305-36. 669 1.00 0.00 C ATOM 14974 03'GUA 18 4.477 5.012-36. 393 1.00 0.00 0 ATOM 14975 1H5'GUA 18 5.109 7.884-35. 957 1.00 0.00 H ATOM 14976 2H5'GUA 18 6.873 7.697-35. 885 1.00 0.00 H ATOM 14977 H4'GUA 18 5.053 6.684-38. 109 1.00 0.00 H ATOM 14978 Hl'GUA 18 7.524 4.788-39. 420 1.00 0.00 H ATOM 14979 1H2 GUA 18 9.343 7.786-33. 032 1.00 0.00 H ATOM 14980 2H2 GUA 18 7.881 7.894-33. 987 1.00 0.00 H ATOM 14981 H1 GUA 18 11.054 6.494-33. 614 1.00 0.00 H ATOM 14982 H8 GUA 18 9.730 3. 445-39. 052 1.00 0.00 H ATOM 14983 H2'GUA 18 6.793 3.426-37. 153 1.00 0.00 H ATOM 14984 H02'GUA 18 5.737 3. 238-39. 182 1.00 0.00 H ATOM 14985 H3'GUA 18 6.467 5.340-35. 769 1.00 0.00 H ATOM 14986 P GUA 19 3.975 4.728-34. 886 1.00 0.00 P ATOM 14987 01P GUA 19 4.388 5.868-34. 039 1.00 0.00 0 ATOM 14988 02P GUA 19 2.551 4.327-34. 941 1.00 0.00 0 ATOM 14989 05'GUA 19 4.845 3.440-34. 454 1.00 0.00 0 ATOM 14990 C5'GUA 19 4.730 2.205-35. 169 1.00 0.00 C ATOM 14991 C4'GUA 19 6.068 1.471-35. 246 1.00 0.00 C ATOM 14992 04'GUA 19 7.130 2.353-35. 655 1.00 0.00 0 ATOM 14993 C1'GUA 19 8.250 2.195-34. 763 1.00 0.00 C ATOM 14994 N9 GUA 19 8.328 3.304-33. 789 1.00 0.00 N ATOM 14995 C4 GUA 19 9.406 3.631-32. 995 1.00 0.00 C ATOM 14996 N3 GUA 19 10.608 3.010-32. 990 1. 00 0.00 N ATOM 14997 C2 GUA 19 11.454 3.554-32. 109 1.00 0.00 C ATOM 14998 N2 GUA 19 12.685 3. 062-31. 976 1.00 0.00 N ATOM 14999 N1 GUA 19 11.133 4.626-31. 300 1.00 0.00 N ATOM 15000 C6 GUA 19 9.908 5.279-31. 288 1.00 0.00 C ATOM 15001 06 GUA 19 9.723 6. 228-30. 530 1.00 0.00 0 ATOM 15002 C5 GUA 19 9.003 4. 708-32. 220 1.00 0.00 C ATOM 15003 N7 GUA 19 7.686 5.064-32. 517 1.00 0.00 N ATOM 15004 C8 GUA 19 7.381 4.204-33. 428 1.00 0.00 C ATOM 15005 C2'GUA 19 8.002 0.877-34. 053 1.00 0.00 C ATOM 15006 02'GUA 19 8.400-0. 240-34.858 1.00 0.00 0 ATOM 15007 C3'GUA 19 6.499 0.942-33. 884 1.00 0.00 C ATOM 15008 03'GUA 19 5.994-0. 387-33.719 1.00 0.00 0 ATOM 15009 1H5'GUA 19 4.378 2.409-36. 179 1.00 0.00 H ATOM 15010 2H5'GUA 19 4.003 1.567-34. 663 1.00 0.00 H ATOM 15011 H4'GUA 19 5.994 0.646-35. 953 1.00 0.00 H ATOM 15012 Hl'GUA 19 9.176 2.139-35. 336 1.00 0.00 H ATOM 15013 1H2 GUA 19 12.979 2.278-32. 541 1.00 0.00 H ATOM 15014 2H2 GUA 19 13.324 3.473-31. 309 1.00 0.00 H ATOM 15015 Hl GUA 19 11.828 4.980-30. 659 1.00 0.00 H ATOM 15016 H8 GUA 19 6.395 4.200-33. 890 1.00 0.00 H ATOM 15017 H2'GUA 19 8.501 0.867-33. 082 1.00 0.00 H ATOM 15018 H02'GUA 19 7.926-0. 176-35.690 1.00 0.00 H ATOM 15019 H3'GUA 19 6.208 1.611-33. 072 1.00 0.00 H ATOM 15020 P ADE 20 5.941-1. 063-32.257 1.00 0.00 P ATOM 15021 01P ADE 20 5.332-2. 406-32.390 1.00 0.00 0 ATOM 15022 02P ADE 20 5. 363-0. 082-31. 312 1.00 0.00 O ATOM 15023 05'ADE 20 7.499-1. 249-31.898 1.00 0.00 0 ATOM 15024 C5'ADE 20 8.314-2. 164-32.637 1.00 0.00 C ATOM 15025 C4'ADE 20 9.789-2. 020-32.274 1.00 0.00 C ATOM 15026 04'ADE 20 10.263-0. 683-32.509 1.00 0.00 0

ATOM 15027 C1'ADE 20 10.997-0. 225-31.358 1.00 0.00 C ATOM 15028 N9 ADE 20 10.215 0.760-30. 582 1.00 0.00 N ATOM 15029 C4 ADE 20 10.708 1.686-29. 689 1.00 0.00 C ATOM 15030 N3 ADE 20 11.998 1. 852-29. 336 1.00 0.00 N ATOM 15031 C2 ADE 20 12.134 2.836-28. 452 1.00 0.00 C ATOM 15032 N1 ADE 20 11.167 3.598-27. 939 1.00 0.00 N ATOM 15033 C6 ADE 20 9.888 3.414-28. 308 1.00 0.00 C ATOM 15034 N6 ADE 20 8.939 4.197-27. 800 1.00 0.00 N ATOM 15035 C5 ADE 20 9.625 2.402-29. 234 1.00 0.00 C ATOM 15036 N7 ADE 20 8.443 1.944-29. 822 1.00 0.00 N ATOM 15037 C8 ADE 20 8.880 0.998-30. 580 1.00 0.00 C ATOM 15038 C2'ADE 20 11.279-1. 471-30.536 1.00 0.00 C ATOM 15039 02'ADE 20 12.446-2. 160-31.004 1.00 0.00 0 ATOM 15040 C3'ADE 20 10.016-2. 267-30.790 1.00 0.00 C ATOM 15041 03'ADE 20 10.296-3. 655-30.591 1.00 0.00 0 ATOM 15042 1H5'ADE 20 8.190-1. 972-33.703 1.00 0.00 H ATOM 15043 2H5'ADE 20 7.992-3. 182-32.419 1.00 0.00 H ATOM 15044 H4'ADE 20 10.382-2. 721-32.859 1.00 0.00 H ATOM 15045 Hl'ADE 20 11.938 0.224-31. 679 1.00 0.00 H ATOM 15046 H2 ADE 20 13.147 3. 041-28. 107 1.00 0.00 H ATOM 15047 1H6 ADE 20 7.977 4.072-28. 082 1.00 0.00 H ATOM 15048 2H6 ADE 20 9.181 4. 920-27. 138 1.00 0.00 H ATOM 15049 H8 ADE 20 8.200 0.402-31. 188 1.00 0.00 H ATOM 15050 H2'ADE 20 11.367-1. 216-29.478 1.00 0.00 H ATOM 15051 H02'ADE 20 13.205-1. 614-30.788 1.00 0.00 H ATOM 15052 H3'ADE 20 9.182-1. 913-30.182 1.00 0.00 H ATOM 15053 P GUA 21 10.206-4. 298-29.118 1.00 0.00 P ATOM 15054 01P GUA 21 8.931-3. 867-28.501 1.00 0.00 0 ATOM 15055 02P GUA 21 10.525-5. 739-29.221 1.00 0.00 0 ATOM 15056 05'GUA 21 11.413-3. 566-28.343 1.00 0.00 0 ATOM 15057 C5'GUA 21 12.770-3. 950-28.583 1.00 0.00 C ATOM 15058 C4'GUA 21 13.732-3. 231-27.643 1.00 0.00 C ATOM 15059 04'GUA 21 13.724-1. 812-27.857 1.00 0.00 0 ATOM 15060 C1'GUA 21 13.673-1. 134-26.588 1.00 0.00 C ATOM 15061 N9 GUA 21 12.357-0. 495-26.380 1.00 0.00 N ATOM 15062 C4 GUA 21 12.091 0.612-25. 604 1.00 0.00 C ATOM 15063 N3 GUA 21 12.984 1.280-24. 839 1.00 0.00 N ATOM 15064 C2 GUA 21 12.428 2.314-24. 199 1.00 0.00 C ATOM 15065 N2 GUA 21 13.163 3.064-23. 378 1.00 0.00 N ATOM 15066 N1 GUA 21 11.096 2.660-24. 315 1.00 0.00 N ATOM 15067 C6 GUA 21 10.162 1.992-25. 095 1.00 0.00 C ATOM 15068 06 GUA 21 9.001 2.391-25. 144 1.00 0.00 0 ATOM 15069 C5 GUA 21 10.742 0.889-25. 773 1.00 0.00 C ATOM 15070 N7 GUA 21 10.155-0. 035-26.642 1.00 0.00 N ATOM 15071 C8 GUA 21 11.157-0. 792-26.937 1.00 0.00 C ATOM 15072 C2'GUA 21 13.948-2. 203-25.539 1.00 0.00 C ATOM 15073 02'GUA 21 15.354-2. 383-25.329 1.00 0.00 0 ATOM 15074 C3'GUA 21 13.320-3. 417-26.192 1.00 0.00 C ATOM 15075 03'GUA 21 13.949-4. 598-25.685 1.00 0.00 0 ATOM 15076 1H5'GUA 21 13.032-3. 710-29.614 1.00 0.00 H ATOM 15077 2H5'GUA 21 12.865-5. 026-28. 434 1.00 0.00 H ATOM 15078 H4'GUA 21 14.742-3. 612-27.789 1.00 0.00 H ATOM 15079 Hl'GUA 21 14.456-0. 375-26.549 1.00 0.00 H ATOM 15080 1H2 GUA 21 14.140 2.852-23. 240 1.00 0.00 H ATOM 15081 2H2 GUA 21 12.740 3.841-22. 889 1.00 0.00 H ATOM 15082 H1 GUA 21 10.753 3.460-23. 802 1.00 0.00 H ATOM 15083 H8 GUA 21 11.038-1. 651-27.595 1.00 0.00 H ATOM 15084 H2'GUA 21 13.436-1. 960-24.606 1.00 0.00 H ATOM 15085 H02'GUA 21 15.749-2. 566-26.184 1.00 0.00 H ATOM 15086 H3'GUA 21 12. 236-3.431-26. 070 1.00 0.00 H

ATOM 15087 P ADE 22 13.252-5. 461-24.517 1.00 0. 00 : ATOM 15088 01P ADE 22 11.784-5. 334-24.657 1.00 0. 00 0 ATOM 15089 02P ADE 22 13.876-6. 803-24.496 1.00 0. 00 0 ATOM 15090 05'ADE 22 13.702-4. 675-23.186 1.00 0. 00 0 ATOM 15091 C5'ADE 22 15.076-4. 656-22.786 1.00 0. 00 C ATOM 15092 C4'ADE 22 15.406-3. 419-21.957 1.00 0. 00 C ATOM 15093 04'ADE 22 15.046-2. 213-22.645 1.00 0. 00 0 ATOM 15094 C1'ADE 22 14.427-1. 299-21.720 1.00 0. 00 C ATOM 15095 N9 ADE 22 12.989-1. 132-22.008 1.00 0.00 N ATOM 15096 C4 ADE 22 12.221-0. 026-21.729 1.00 0.00 C ATOM 15097 N3 ADE 22 12.642 1.110-21. 141 1.00 0.00 N ATOM 15098 C2 ADE 22 11.651 1.985-21. 015 1.00 0. 00 C ATOM 15099 N1 ADE 22 10.383 1.827-21. 399 1.00 0.00 N ATOM 15100 C6 ADE 22 9.988 0.681-21. 985 1.00 0. 00 C ATOM 15101 N6 ADE 22 8.719 0.539-22. 363 1.00 0.00 N ATOM 15102 C5 ADE 22 10.950-0. 313-22.167 1.00 0.00 C ATOM 15103 N7 ADE 22 10.892-1. 593-22.725 1.00 0.00 N ATOM 15104 C8 ADE 22 12.112-1. 989-22.589 1.00 0.00 C ATOM 15105 C2'ADE 22 14.639-1. 903-20.339 1.00 0.00 C ATOM 15106 02'ADE 22 15.900-1. 507-19. 786 1.00 0. 00 0 ATOM 15107 C3'ADE 22 14.609-3. 382-20. 664 1.00 0.00 C ATOM 15108 03'ADE 22 15.333-4. 094-19.654 1.00 0. 00 0 ATOM 15109 1H5'ADE 22 15.706-4. 665-23.675 1.00 0. 00 H ATOM 15110 2H5'ADE 22 15.285-5. 547-22.193 1.00 0. 00 H ATOM 15111 H4'ADE 22 16.471-3. 400-21.732 1.00 0. 00 H ATOM 15112 H1'ADE 22 14.925-0. 331-21.775 1.00 0. 00 H ATOM 15113 H2 ADE 22 11. 902 2.937-20. 546 1.00 0. 00 H ATOM 15114 1H6 ADE 22 8. 417-0. 318-22.803 1.00 0.00 H ATOM 15115 2H6 ADE 22 8.060 1.290-22. 210 1.00 0. 00 H ATOM 15116 H8 ADE 22 12.424-2. 975-22.927 1.00 0.00 H ATOM 15117 H2'ADE 22 13.813-1. 638-19.675 1.00 0.00 H ATOM 15118 H02'ADE 22 15. 794-0. 615-19.446 1.00 0.00 H ATOM 15119 H3'ADE 22 13.590-3. 752-20.795 1.00 0. 00 H ATOM 15120 P CYT 23 14.641-4. 438-18.240 1. 00 0. 00 P ATOM 15121 01P CYT 23 13.262-4. 908-18.502 1.00 0. 00 0 ATOM 15122 02P CYT 23 15.573-5. 283-17.461 1.00 0.00 0 ATOM 15123 05'CYT 23 14.554-2. 995-17.529 1.00 0. 00 0 ATOM 15124 C5'CYT 23 15.744-2. 282-17.180 1.00 0. 00 C ATOM 15125 C4'CYT 23 15.442-0. 841-16.779 1.00 0. 00 C ATOM 15126 04'CYT 23 14.722-0. 144-17.795 1.00 0. 00 0 ATOM 15127 C1'CYT 23 13.849 0.824-17. 181 1.00 0.00 C ATOM 15128 N1 CYT 23 12.450 0.653-17. 634 1.00 0.00 N ATOM 15129 C6 CYT 23 11.943-0. 585-17.909 1.00 0.00 C ATOM 15130 C2 CYT 23 11.677 1.799-17. 775 1.00 0.00 C ATOM 15131 02 CYT 23 12.154 2.904-17. 521 1.00 0. 00 0 ATOM 15132 N3 CYT 23 10.391 1.662-18. 198 1.00 0.00 N ATOM 15133 C4 CYT 23 9.881 0.456-18. 472 1.00 0.00 C ATOM 15134 N4 CYT 23 8.619 0.362-18. 890 1.00 0.00 N ATOM 15135 C5 CYT 23 10.671-0. 728-18.328 1.00 0.00 C ATOM 15136 C2'CYT 23 13.970 0.623-15. 666 1.00 0.00 C ATOM 15137 02'CYT 23 14.855 1.587-15. 083 1.00 0.00 0 ATOM 15138 C3'CYT 23 14.535-0. 785-15.569 1.00 0.00 C ATOM 15139 03'CYT 23 15.348-0. 883-14.395 1.00 0.00 0 ATOM 15140 1H5'CYT 23 16.420-2. 277-18.036 1.00 0.00 H ATOM 15141 2H5'CYT 23 16. 231-2. 789-16.346 1.00 0.00 H ATOM 15142 H4'CYT 23 16.371-0. 314-16.567 1.00 0.00 H ATOM 15143 H1'CYT 23 14.191 1.828-17. 438 1.00 0.00 H ATOM 15144 H6 CYT 23 12. 573-1.466-17. 787 1. 00 0.00 H ATOM 15145 1H4 CYT 23 8.223-0. 543-19.103 1.00 0.00 H ATOM 15146 2H4 CYT 23 8.058 1.195-18. 993 1.00 0.00 H

ATOM 15147 H5 CYT 23 10.256-1. 711-18.547 1.00 0.00 H ATOM 15148 H2'CYT 23 12.982 0.667-15. 200 1.00 0.00 H ATOM 15149 H02'CYT 23 14.440 2. 447-15. 173 1.00 0.00 H ATOM 15150 H3'CYT 23 13.752-1. 544-15.604 1.00 0.00 H ATOM 15151 P GUA 24 14. 698-1. 227-12. 963 1.00 0.00 P ATOM 15152 O1P GUA 24 15.782-1. 665-12.056 1.00 0.00 0 ATOM 15153 02P GUA 24 13. 522-2. 100-13.183 1.00 0.00 O ATOM 15154 05'GUA 24 14.171 0.209-12. 463 1.00 0.00 0 ATOM 15155 C5'GUA 24 15.083 1.295-12. 274 1.00 0.00 C ATOM 15156 C4'GUA 24 14.409 2.477-11. 584 1.00 0.00 C ATOM 15157 04'GUA 24 13.272 2.943-12. 332 1.00 0.00 0 ATOM 15158 C1'GUA 24 12.133 3.028-11. 459 1.00 0.00 C ATOM 15159 N9 GUA 24 11.226 1.882-11. 645 1.00 0.00 N ATOM 15160 C4 GUA 24 10.013 1.704-11. 029 1.00 0.00 C ATOM 15161 N3 GUA 24 9.444 2.559-10. 153 1.00 0.00 N ATOM 15162 C2 GUA 24 8.263 2.121-9. 719 1.00 0.00 C ATOM 15163 N2 GUA 24 7.562 2.851-8. 853 1.00 0.00 N ATOM 15164 N1 GUA 24 7.694 0.931-10. 123 1.00 0.00 N ATOM 15165 C6 GUA 24 8.259 0.036-11. 021 1.00 0.00 C ATOM 15166 06 GUA 24 7.668-1. 001-11.314 1.00 0.00 0 ATOM 15167 C5 GUA 24 9.517 0.496-11. 489 1.00 0.00 C ATOM 15168 N7 GUA 24 10.408-0. 092-12.392 1. 00 0.00 N ATOM 15169 C8 GUA 24 11.361 0.778-12. 419 1.00 0.00 C ATOM 15170 C2'GUA 24 12.708 3.043-10. 055 1.00 0.00 C ATOM 15171 02'GUA 24 13.160 4.351-9. 683 1.00 0.00 0 ATOM 15172 C3'GUA 24 13.860 2.075-10. 220 1.00 0.00 C ATOM 15173 03'GUA 24 14.849 2.354-9. 225 1.00 0.00 O ATOM 15174 1H5'GUA 24 15.459 1.618-13. 245 1.00 0.00 H ATOM 15175 2H5'GUA 24 15.920 0.956-11. 663 1.00 0.00 H ATOM 15176 H4'GUA 24 15.123 3.291-11. 467 1.00 0.00 H ATOM 15177 Hl'GUA 24 11. 589 3. 955-11.643 1.00 0.00 H ATOM 15178 1H2 GUA 24 7.926 3.735-8. 527 1.00 0.00 H ATOM 15179 2H2 GUA 24 6.667 2. 522-8. 524 1.00 0.00 H ATOM 15180 H1 GUA 24 6.799 0.670-9. 747 1.00 0.00 H ATOM 15181 H8 GUA 24 12.244 0.629-13. 041 1.00 0.00 H ATOM 15182 H2'GUA 24 11.978 2.656-9. 341 1.00 0.00 H ATOM 15183 H02'GUA 24 13.758 4.652-10. 371 1.00 0.00 H ATOM 15184 H3'GUA 24 13.525 1.036-10. 202 1.00 0.00 H ATOM 15185 P ADE 25 14.794 1. 627-7. 787 1.00 0.00 P ATOM 15186 01P ADE 25 16.015 1.995-7. 035 1.00 0.00 0 ATOM 15187 02P ADE 25 14.461 0.200-8. 001 1.00 0.00 0 ATOM 15188 05'ADE 25 13.533 2.338-7. 083 1.00 0.00 0 ATOM 15189 C5'ADE 25 13.540 3.748-6. 840 1.00 0.00 C ATOM 15190 C4'ADE 25 12.163 4.256-6. 422 1.00 0.00 C ATOM 15191 04'ADE 25 11.160 3.923-7. 393 1.00 0.00 0 ATOM 15192 C1'ADE 25 9.998 3.402-6. 722 1.00 0.00 C ATOM 15193 N9 ADE 25 9.871 1.944-6. 928 1.00 0.00 N ATOM 15194 C4 ADE 25 8.809 1.149-6. 556 1.00 0.00 C ATOM 15195 N3 ADE 25 7.687 1.554-5. 930 1.00 0.00 N ATOM 15196 C2 ADE 25 6.860 0.536-5. 714 1.00 0.00 C ATOM 15197 N1 ADE 25 7.050-0. 743-6.045 1.00 0.00 N ATOM 15198 C6 ADE 25 8. 179-1. 122-6. 670 1.00 0.00 C ATOM 15199 N6 ADE 25 8.351-2. 403-6.993 1.00 0.00 N ATOM 15200 C5 ADE 25 9.125-0. 131-6.949 1.00 0.00 C ATOM 15201 N7 ADE 25 10.377-0. 167-7.569 1.00 0.00 N ATOM 15202 C8 ADE 25 10.731 1.072-7. 511 1.00 0.00 C ATOM 15203 C2'ADE 25 10.194 3.733-5. 250 1.00 0.00 C ATOM 15204 02'ADE 25 9.749 5.060-4. 944 1.00 0.00 0 ATOM 15205 C3'ADE 25 11.697 3.603-5. 130 1.00 0.00 C ATOM 15206 03'ADE 25 12.148 4.398-4. 029 1.00 0.00 0

ATOM 15207 1H5'ADE 25 13.847 4.264-7. 750 1.00 0.00 H ATOM 15208 2H5'ADE 25 14.256 3.969-6. 047 1.00 0.00 H ATOM 15209 H4'ADE 25 12.195 5.337-6. 295 1.00 0.00 H ATOM 15210 H1'ADE 25 9.105 3.904-7. 094 1.00 0.00 H ATOM 15211 H2 ADE 25 5.923 0.772-5. 208 1.00 0.00 H ATOM 15212 1H6 ADE 25 9.196-2. 695-7.463 1.00 0.00 H ATOM 15213 2H6 ADE 25 7.637-3. 082-6.768 1.00 0.00 H ATOM 15214 H8 ADE 25 11.687 1.405-7. 912 1.00 0.00 H ATOM 15215 H2'ADE 25 9.693 2.991-4. 622 1.00 0.00 H ATOM 15216 H02'ADE 25 10.174 5.654-5. 567 1.00 0.00 H ATOM 15217 H3'ADE 25 12. 010 2.560-5. 054 1.00 0.00 H ATOM 15218 P CYT 26 12.153 3.794-2. 538 1.00 0.00 P ATOM 15219 01P CYT 26 12.714 2.426-2. 590 1.00 0.00 0 ATOM 15220 02P CYT 26 12.747 4.802-1. 631 1.00 0.00 0 ATOM 15221 05'CYT 26 10.583 3.680-2. 209 1.00 0.00 O ATOM 15222 C5'CYT 26 9.803 4.855-1. 973 1.00 0.00 C ATOM 15223 C4'CYT 26 8.380 4.504-1. 553 1.00 0.00 C ATOM 15224 04'CYT 26 7.664 3.828-2. 596 1.00 0.00 0 ATOM 15225 C1'CYT 26 6. 914 2.736-2. 027 1.00 0.00 C ATOM 15226 N1 CYT 26 7.476 1.430-2. 430 1.00 0.00 N ATOM 15227 C6 CYT 26 8.813 1.284-2. 663 1. 00 0. 00 C ATOM 15228 C2 CYT 26 6.601 0.356-2. 531 1.00 0.00 C ATOM 15229 02 CYT 26 5.400 0.514-2. 320 1.00 0.00 0 ATOM 15230 N3 CYT 26 7.110-0. 860-2.868 1.00 0.00 N ATOM 15231 C4 CYT 26 8.419-1. 018-3.096 1.00 0.00 C ATOM 15232 N4 CYT 26 8.884-2. 223-3.423 1.00 0.00 N ATOM 15233 C5 CYT 26 9.322 0.087-2. 993 1.00 0.00 C ATOM 15234 C2'CYT 26 7.002 2. 917-0. 517 1.00 0.00 C ATOM 15235 02'CYT 26 5.980 3. 794-0. 028 1.00 0.00 0 ATOM 15236 C3'CYT 26 8.379 3.531-0. 388 1.00 0.00 C ATOM 15237 03'CYT 26 8.452 4.277 0.831 1.00 0.00 0 ATOM 15238 1H5'CYT 26 9.769 5. 452-2. 885 1.00 0.00 H ATOM 15239 2H5'CYT 26 10.272 5.440-1. 181 1.00 0.00 H ATOM 15240 H4'CYT 26 7.844 5.411-1. 275 1.00 0.00 H ATOM 15241 H1'CYT 26 5.874 2.802-2. 344 1.00 0.00 H ATOM 15242 H6 CYT 26 9.474 2.149-2. 592 1.00 0.00 H ATOM 15243 1H4 CYT 26 9. 870-2. 354-3. 598 1.00 0.00 H ATOM 15244 2H4 CYT 26 8.249-3. 005-3.496 1.00 0.00 H ATOM 15245 H5 CYT 26 10.389-0. 038-3.155 1.00 0.00 H ATOM 15246 H2'CYT 26 6.966 1.946-0. 015 1.00 0.00 H ATOM 15247 H02'CYT 26 6.005 4.589-0. 566 1.00 0.00 H ATOM 15248 H3'CYT 26 9.170 2.781-0. 478 1.00 0.00 H ATOM 15249 P CYT 27 9.597 3.958 1.919 1. 00 0. 00 P ATOM 15250 O1P CYT 27 10.831 3.572 1.197 1.00 0.00 0 ATOM 15251 02P CYT 27 9.631 5.068 2.896 1.00 0.00 0 ATOM 15252 05'CYT 27 9.018 2.651 2.658 1.00 0.00 0 ATOM 15253 C5'CYT 27 7.756 2. 700 3.330 1.00 0.00 C ATOM 15254 C4'CYT 27 7.021 1.366 3.246 1.00 0.00 C ATOM 15255 04'CYT 27 6.890 0. 918 1.894 1.00 0.00 0 ATOM 15256 C1'CYT 27 6.980-0. 521 1.861 1.00 0.00 C ATOM 15257 N1 CYT 27 8.110-0. 986 1.023 1.00 0.00 N ATOM 15258 C6 CYT 27 9.131-0. 147 0.671 1.00 0.00 C ATOM 15259 C2 CYT 27 8.099-2. 316 0.627 1.00 0.00 C ATOM 15260 02 CYT 27 7.172-3. 050 0.960 1.00 0.00 0 ATOM 15261 N3 CYT 27 9.134-2. 777-0.123 1.00 0.00 N ATOM 15262 C4 CYT 27 10.142-1. 972-0.475 1.00 0.00 C ATOM 15263 N4 CYT 27 11.137-2. 461-1.214 1.00 0.00 N ATOM 15264 C5 CYT 27 10. 163-0. 599-0. 072 1.00 0.00 C ATOM 15265 C2'CYT 27 7.164-0. 971 3.310 1.00 0.00 C ATOM 15266 02'CYT 27 5.910-1. 292 3.924 1.00 0.00 0

ATOM 15267 C3'CYT 27 7.793 0.257 3.934 1.00 0.00 C ATOM 15268 03'CYT 27 7.486 0.275 5.333 1.00 0.00 0 ATOM 15269 1H5'CYT 27 7.139 3.473 2.873 1.00 0.00 H ATOM 15270 2H5'CYT 27 7.921 2.950 4.378 1.00 0.00 H ATOM 15271 H4'CYT 27 6.033 1.459 3.693 1.00 0.00 H ATOM 15272 Hl'CYT 27 6.048-0. 931 1.472 1.00 0.00 H ATOM 15273 H6 CYT 27 9.108 0.895 0.989 1.00 0.00 H ATOM 15274 1H4 CYT 27 11.903-1. 863-1.490 1.00 0.00 H ATOM 15275 2H4 CYT 27 11.125-3. 430-1.497 1.00 0.00 H ATOM 15276 H5 CYT 27 10.989 0.057-0. 351 1.00 0.00 H ATOM 15277 H2'CYT 27 7.854-1. 817 3.358 1.00 0.00 H ATOM 15278 H02'CYT 27 6.083-1. 466 4.852 1.00 0.00 H ATOM 15279 H3'CYT 27 8.865 0.315 3.735 1.00 0.00 H ATOM 15280 P GUA 28 8.385-0. 558 6.380 1.00 0.00 P ATOM 15281 O1P GUA 28 9.781-0. 570 5.888 1.00 0.00 0 ATOM 15282 02P GUA 28 8.089-0. 060 7.743 1.00 0.00 0 ATOM 15283 05'GUA 28 7.794-2. 052 6.247 1.00 0.00 0 ATOM 15284 C5'GUA 28 6.631-2. 444 6.985 1.00 0.00 C ATOM 15285 C4'GUA 28 6.393-3. 950 6.906 1.00 0.00 C ATOM 15286 04'GUA 28 6.202-4. 388 5.554 1.00 0.00 0 ATOM 15287 Cl'GUA 28 6.910-5. 627 5.348 1.00 0.00 C ATOM 15288 N9 GUA 28 8.054-5. 444 4.432 1.00 0.00 N ATOM 15289 C4 GUA 28 8. 717-6.433 3.740 1.00 0.00 C ATOM 15290 N3 GUA 28 8.435-7. 754 3.779 1.00 0.00 N ATOM 15291 C2 GUA 28 9.253-8. 469 3.002 1.00 0.00 C ATOM 15292 N2 GUA 28. 9.115-9. 793 2.931 1.00 0.00 N ATOM 15293 N1 GUA 28 10.268-7. 916 2.245 1.00 0.00 N ATOM 15294 C6 GUA 28 10.576-6. 563 2.188 1.00 0.00 C ATOM 15295 06 GUA 28 11.500-6. 171 1.480 1.00 0.00 0 ATOM 15296 C5 GUA 28 9.712-5. 796 3.013 1.00 0.00 C ATOM 15297 N7 GUA 28 9.682-4. 417 3.241 1.00 0.00 N ATOM 15298 C8 GUA 28 8.699-4. 309 4.069 1.00 0.00 C ATOM 15299 C2'GUA 28 7.382-6. 069 6.728 1.00 0.00 C ATOM 15300 02'GUA 28 6.382-6. 843 7.402 1.00 0.00 0 ATOM 15301 C3'GUA 28 7.599-4. 730 7.399 1.00 0.00 C ATOM 15302 03'GUA 28 7.495-4. 902 8.816 1.00 0.00 0 ATOM 15303 1H5'GUA 28 5.761-1. 925 6.581 1.00 0.00 H ATOM 15304 2H5'GUA 28 6.761-2. 160 8.029 1.00 0.00 H ATOM 15305 H4'GUA 28 5.518-4. 215 7.497 1.00 0.00 H ATOM 15306 Hl'GUA 28 6.229-6. 373 4.939 1.00 0.00 H ATOM 15307 1H2 GUA 28 8.392-10. 254 3.465 1.00 0.00 H ATOM 15308 2H2 GUA 28 9.734-10. 335 2.346 1.00 0.00 H ATOM 15309 HI GUA 28 10.843-8. 526 1.681 1.00 0.00 H ATOM 15310 H8 GUA 28 8.402-3. 340 4.469 1.00 0.00 H ATOM 15311 H2'GUA 28 8.323-6. 618 6.650 1.00 0.00 H ATOM 15312 H02'GUA 28 6.503-6. 704 8.344 1.00 0.00 H ATOM 15313 H3'GUA 28 8.541-4. 269 7.097 1.00 0.00 H ATOM 15314 P CYT 29 8.810-5. 191 9.701 1.00 0.00 P ATOM 15315 01P CYT 29 8.398-5. 301 11.119 1.00 0.00 0 ATOM 15316 02P CYT 29 9.855-4. 219 9.310 1.00 0.00 0 ATOM 15317 05'CYT 29 9.263-6. 649 9.190 1.00 0.00 0 ATOM 15318 C5'CYT 29 8.552-7. 821 9.603 1.00 0.00 C ATOM 15319 C4'CYT 29 9.062-9. 070 8.889 1.00 0.00 C ATOM 15320 04'CYT 29 8. 949-8.950 7.465 1.00 0.00 O ATOM 15321 C1'CYT 29 10.136-9. 481 6.841 1.00 0.00 C ATOM 15322 N1 CYT 29 10.923-8. 412 6.182 1.00 0.00 N ATOM 15323 C6 CYT 29 10.837-7. 114 6.599 1.00 0.00 C ATOM 15324 C2 CYT 29 11.744-8. 778 5.122 1.00 0.00 C ATOM 15325 02 CYT 29 11.813-9. 953 4.767 1.00 0.00 0 ATOM 15326 N3 CYT 29 12. 465-7. 806 4.499 1.00 0. 00 N

ATOM 15327 C4 CYT 29 12.388-6. 529 4.896 1.00 0.00 C ATOM 15328 N4 CYT 29 13.103-5. 603 4.259 1.00 0.00 N ATOM 15329 C5 CYT 29 11.547-6. 148 5.987 1.00 0.00 C ATOM 15330 C2'CYT 29 10.934-10. 143 7.959 1.00 0.00 C ATOM 15331 02'CYT 29 10.547-11. 511 8.143 1.00 0.00 O ATOM 15332 C3'CYT 29 10.544-9. 286 9.145 1.00 0.00 C ATOM 15333 03'CYT 29 10.695-10. 055 10.343 1.00 0.00 O ATOM 15334 1H5'CYT 29 7.493-7. 692 9.380 1.00 0.00 H ATOM 15335 2H5'CYT 29 8.675-7. 951 10.678 1.00 0.00 H ATOM 15336 H4'CYT 29 8.501-9. 940 9.224 1.00 0.00 H ATOM 15337 H1'CYT 29 9.852-10. 232 6.103 1.00 0.00 H ATOM 15338 H6 CYT 29 10.191-6. 859 7.438 1.00 0.00 H ATOM 15339 1H4 CYT 29 13.049-4. 636 4.547 1.00 0.00 H ATOM 15340 2H4 CYT 29 13.701-5. 868 3.489 1.00 0.00 H ATOM 15341 H5 CYT 29 11.482-5. 109 6.313 1.00 0.00 H ATOM 15342 H2'CYT 29 12.004-10. 059 7.761 1.00 0.00 H ATOM 15343 H02'CYT 29 9.607-11. 518 8.336 1.00 0.00 H ATOM 15344 H3'CYT 29 11.099-8. 348 9.172 1.00 0.00 H ATOM 15345 P CYT 30 12.039-9. 943 11.222 1.00 0.00 P ATOM 15346 01P CYT 30 12.464-8. 525 11.243 1.00 0.00 0 ATOM 15347 02P CYT 30 11.821-10. 665 12.496 1.00 0.00 0 ATOM 15348 05'CYT 30 13.104-10. 774 10.346 1.00 0.00 0 ATOM 15349 C5'CYT 30 13.046-12. 203 10.289 1.00 0.00 C ATOM 15350 C4'CYT 30 13.927-12. 756 9.173 1.00 0.00 C ATOM 15351 04'CYT 30 13.556-12. 225 7.896 1.00 0.00 0 ATOM 15352 C1'CYT 30 14.743-11. 964 7.126 1.00 0.00 C ATOM 15353 N1 CYT 30 14.910-10. 517 6.864 1.00 0.00 N ATOM 15354 C6 CYT 30 14.416-9. 580 7.727 1.00 0.00 C ATOM 15355 C2 CYT 30 15.582-10. 149 5.706 1.00 0.00 C ATOM 15356 02 CYT 30 16.027-11. 009 4.948 1.00 0.00 0 ATOM 15357 N3 CYT 30 15.740-8. 823 5.444 1.00 0.00 N ATOM 15358 C4 CYT 30 15.261-7. 894 6.280 1.00 0.00 C ATOM 15359 N4 CYT 30 15.435-6. 605 5.993 1.00 0.00 N ATOM 15360 C5 CYT 30 14.568-8. 266 7.475 1.00 0.00 C ATOM 15361 C2'CYT 30 15.904-12. 515 7.950 1.00 0.00 C ATOM 15362 02'CYT 30 16.159-13. 890 7.639 1.00 0.00 0 ATOM 15363 C3'CYT 30 15.379-12. 351 9.360 1.00 0.00 C ATOM 15364 03'CYT 30 16.060-13. 205 10.287 1.00 0.00 0 ATOM 15365 1H5'CYT 30 12.015-12. 511 10.113 1.00 0.00 H ATOM 15366 2H5'CYT 30 13.382-12. 611 11.243 1.00 0.00 H ATOM 15367 H4'CYT 30 13.850-13. 842 9.148 1.00 0.00 H ATOM 15368 H1'CYT 30 14.684-12. 502 6.179 1.00 0.00 H ATOM 15369 H6 CYT 30 13.896-9. 899 8.630 1.00 0.00 H ATOM 15370 1H4 CYT 30 15.078-5. 896 6.616 1.00 0.00 H ATOM 15371 2H4 CYT 30 15.933-6. 338 5.156 1.00 0.00 H ATOM 15372 H5 CYT 30 14.175-7. 512 8.157 1.00 0.00 H ATOM 15373 H2'CYT 30 16.799-11. 904 7.801 1.00 0.00 H ATOM 15374 H02'CYT 30 16.767-14. 225 8.302 1.00 0.00 H ATOM 15375 H3'CYT 30 15.443-11. 302 9.665 1.00 0.00 H ATOM 15376 H03'CYT 30 16.955-12. 871 10.378 1.00 0.00 H TER ATOM 15377 05'GUA 1-15.113-15. 900-6.425 1.00 0.00 0 ATOM 15378 C5'GUA 1-14.581-17. 174-6.050 1.00 0.00 C ATOM 15379 C4'GUA 1-13.708-17. 767-7.154 1.00 0.00 C ATOM 15380 04'GUA 1-14.447-17. 932-8.376 1.00 0.00 0 ATOM 15381 C1'GUA 1-13.702-17. 366-9.468 1.00 0.00 C ATOM 15382 N9 GUA 1-14.268-16. 065-9.883 1.00 0.00 N ATOM 15383 C4 GUA 1-14.038-15. 409-11.073 1.00 0.00 C ATOM 15384 N3 GUA 1-13.247-15. 844-12.080 1.00 0.00 N ATOM 15385 C2 GUA 1-13.220-14. 989-13.106 1.00 0.00 C

ATOM 15386 N2 GUA 1-12. 481-15.260-14. 182 1.00 0.00 N ATOM 15387 N1 GUA 1-13.923-13. 800-13.131 1.00 0.00 N ATOM 15388 C6 GUA 1-14.741-13. 333-12.112 1.00 0.00 C ATOM 15389 06 GUA 1-15.324-12. 258-12.232 1.00 0.00 0 ATOM 15390 C5 GUA 1-14.774-14. 235-11.016 1.00 0.00 C ATOM 15391 N7 GUA 1-15.465-14. 145-9.805 1.00 0.00 N ATOM 15392 C8 GUA 1-15.113-15. 239-9.219 1.00 0.00 C ATOM 15393 C2'GUA 1-12. 283-17.204-8. 948 1.00 0.00 C ATOM 15394 02'GUA 1-11.539-18. 423-9.060 1.00 0.00 0 ATOM 15395 C3'GUA 1-12.551-16. 840-7.502 1.00 0.00 C ATOM 15396 03'GUA 1-11.414-17. 209-6.715 1.00 0.00 0 ATOM 15397 H5'GUA 1-14.371-15. 298-6.523 1.00 0.00 H ATOM 15398 1H5'GUA 1-15.405-17. 856-5.843 1.00 0.00 H ATOM 15399 2H5'GUA 1-13.982-17. 056-5.147 1.00 0.00 H ATOM 15400 H4'GUA 1-13.320-18. 733-6.835 1.00 0.00 H ATOM 15401 H1'GUA 1-13.708-18. 056-10.312 1. 00 0.00 H ATOM 15402 1H2 GUA 1-11.941-16. 112-14.221 1.00 0.00 H ATOM 15403 2H2 GUA 1-12.461-14. 613-14.957 1.00 0.00 H ATOM 15404 H1 GUA 1-13.852-13. 209-13.946 1.00 0.00 H ATOM 15405 H8 GUA 1-15.480-15. 489-8.224 1.00 0.00 H ATOM 15406 H2'GUA 1-11. 780-16.384-9. 464 1.00 0.00 H ATOM 15407 H02'GUA 1-12.036-19. 105-8.602 1.00 0.00 H ATOM 15408 H3'GUA 1-12.818-15. 788-7.389 1.00 0.00 H ATOM 15409 P GUA 2-10.223-16. 157-6.453 1.00 0.00 P ATOM 15410 O1P GUA 2-9.176-16. 834-5.655 1.00 0.00 0 ATOM 15411 02P GUA 2-10.819-14. 893-5.967 1.00 0.00 0 ATOM 15412 05'GUA 2-9.645-15. 905-7.935 1.00 0.00 0 ATOM 15413 C5'GUA 2-8.938-16. 940-8.626 1.00 0.00 C ATOM 15414 C4'GUA 2-8.680-16. 571-10. 085 1.00 0.00 C ATOM 15415 04'GUA 2-9.897-16. 309-10.789 1.00 0.00 0 ATOM 15416 C1'GUA 2-9.681-15. 246-11.739 1.00 0.00 C ATOM 15417 N9 GUA 2-10. 560-14.091-11. 463 1.00 0.00 N ATOM 15418 C4 GUA 2-10.841-13. 052-12.323 1.00 0.00 C ATOM 15419 N3 GUA 2-10.344-12. 900-13.572 1.00 0.00 N ATOM 15420 C2 GUA 2-10.800-11. 793-14.166 1.00 0.00 C ATOM 15421 N2 GUA 2-10.402-11. 488-15.400 1.00 0.00 N ATOM 15422 N1. GUA 2-11.679-10. 911-13.570 1.00 0.00 N ATOM 15423 C6 GUA 2-12.203-11. 045-12.291 1.00 0.00 C ATOM 15424 06 GUA 2-12.984-10. 204-11.854 1.00 0.00 0 ATOM 15425 C5 GUA 2-11.722-12. 219-11.651 1.00 0.00 C ATOM 15426 N7 GUA 2-11.997-12. 719-10.376 1.00 0.00 N ATOM 15427 C8 GUA 2-11.286-13. 796-10.355 1.00 0.00 C ATOM 15428 C2'GUA 2-8.208-14. 856-11.619 1.00 0.00 C ATOM 15429 02'GUA 2-7.401-15. 555-12.575 1.00 0.00 0 ATOM 15430 C3'GUA 2-7.890-15. 282-10.200 1.00 0.00 C ATOM 15431 03'GUA 2-6.495-15. 589-10.112 1.00 0.00 0 ATOM 15432 1H5'GUA 2-9.525-17. 857-8.591 1.00 0.00 H ATOM 15433 2H5'GUA 2-7.982-17. 110-8.129 1.00 0.00 H ATOM 15434 H4'GUA 2-8.143-17. 378-10.580 1.00 0.00 H ATOM 15435 H1'GUA 2-9.875-15. 617-12.745 1.00 0.00 H ATOM 15436 1H2 GUA 2-9.756-12. 093-15.887 1.00 0.00 H ATOM 15437 2H2 GUA 2-10.745-10. 650-15.849 1.00 0.00 H ATOM 15438 H1 GUA 2-11.979-10. 098-14. OB8 1.00 0.00 H ATOM 15439 H8 GUA 2-11.269-14. 443-9.479 1.00 0.00 H ATOM 15440 H2'GUA 2-8.095-13. 775-11.726 1.00 0.00 H ATOM 15441 H02'GUA 2-7.559-15. 152-13.431 1.00 0.00 H ATOM 15442 H3'GUA 2-8.206-14. 537-9.468 1.00 0. 00 H ATOM 15443 P CYT 3-5.419-14. 428-9.819 1.00 0.00 P ATOM 15444 01P CYT 3-5.927-13. 594-8.706 1.00 0.00 0

ATOM 15445 02P CYT 3-4.080-15. 052-9.721 1.00 0.00 0 ATOM 15446 05'CYT 3-5.471-13. 551-11.169 1.00 0.00 O ATOM 15447 C5'CYT 3-4.697-13. 923-12.312 1.00 0.00 C ATOM 15448 C4'CYT 3-4.782-12. 870-13.414 1. 00 0.00 C ATOM 15449 04'CYT 3-6.121-12. 727-13.912 1.00 0.00 0 ATOM 15450 C1'CYT 3-6.432-11. 327-14.055 1.00 0.00 C ATOM 15451 N1 CYT 3-7.412-10. 887-13.037 1.00 0.00 N ATOM 15452 C6 CYT 3-7.406-11. 424-11.782 1.00 0.00 C ATOM 15453 C2 CYT 3-8.330-9. 913-13.403 1.00 0. 00 C ATOM 15454 02 CYT 3-8.311-9. 437-14.536 1.00 0.00 0 ATOM 15455 N3 CYT 3-9.237-9. 501-12.475 1.00 0.00 N ATOM 15456 C4 CYT 3-9.242-10. 020-11.240 1.00 0.00 C ATOM 15457 N4 CYT 3-10.146-9. 598-10.358 1.00 0.00 N ATOM 15458 C5 CYT 3-8.296-11. 022-10.859 1.00 0.00 C ATOM 15459 C2'CYT 3-5.107-10. 595-13.889 1.00 0.00 C ATOM 15460 02'CYT 3-4.386-10. 520-15.126 1.00 0.00 0 ATOM 15461 C3'CYT 3-4.413-11. 492-12.889 1.00 0.00 C ATOM 15462 03'CYT 3-2.999-11. 313-13.008 1.00 0.00 O ATOM 15463 1H5'CYT 3-5.064-14. 874-12.699 1.00 0.00 H ATOM 15464 2H5'CYT 3-3.655-14. 038-12. 013 1.00 0.00 H ATOM 15465 H4'CYT 3-4.119-13. 140-14.234 1.00 0.00 H ATOM 15466 H1'CYT 3-6.831-11. 141-15.053 1.00 0.00 H ATOM 15467 H6 CYT 3-6.672-12. 187-11.525 1.00 0.00 H ATOM 15468 1H4 CYT 3-10.162-9. 985-9.425 1.00 0.00 H ATOM 15469 2H4 CYT 3-10.815-8. 887-10.620 1.00 0.00 H ATOM 15470 H5 CYT 3-8.290-11. 441-9.854 1.00 0.00 H ATOM 15471 H2'CYT 3-5.271-9. 601-13.465 1.00 0.00 H ATOM 15472 H02'CYT 3-4.841-9. 883-15.683 1.00 0.00 H ATOM 15473 H3'CYT 3-4.777-11. 328-11.871 1.00 0.00 H ATOM 15474 P GUA 4-2.233-10. 253-12.069 1.00 0.00 P ATOM 15475 01P GUA 4-2.609-10. 523-10.663 1.00 0.00 O ATOM 15476 02P GUA 4-0.806-10. 235-12. 460 1.00 0.00 0 ATOM 15477 05'GUA 4-2.896-8. 852-12.508 1.00 0.00 0 ATOM 15478 C5'GUA 4-2.626-8. 297-13.799 1.00 0.00 C ATOM 15479 C4'GUA 4-3.587-7. 162-14.144 1.00 0.00 C ATOM 15480 04'GUA 4-4.953-7. 578-14.091 1.00 0.00 O ATOM 15481 C1'GUA 4-5.768-6. 452-13.704 1.00 0.00 C ATOM 15482 N9 GUA 4-6.575-6. 746-12.503 1.00 0.00 N ATOM 15483 C4 GUA 4-7.579-5. 960-11. 988 1.00 0.00 C ATOM 15484 N3 GUA 4-8.006-4. 788-12.507 1.00 0.00 N ATOM 15485 C2 GUA 4-8.992-4. 247-11.790 1.00 0.00 C ATOM 15486 N2 GUA 4-9.525-3. 086-12.168 1.00 0.00 N ATOM 15487 N1 GUA 4-9.515-4. 8. 23-10. 648 1.00 0.00 N ATOM 15488 C6 GUA 4-9.094-6. 027-10.096 1.00 0.00 C ATOM 15489 06 GUA 4-9.630-6. 459-9.078 1.00 0.00 O ATOM 15490 C5 GUA 4-8.041-6. 608-10.855 1.00 0.00 C ATOM 15491 N7 GUA 4-7.338-7. 800-10.650 1.00 0.00 N ATOM 15492 C8 GUA 4-6.516-7. 796-11.646 1.00 0.00 C ATOM 15493 C2'GUA 4-4.803-5. 295-13.434 1.00 0.00 C ATOM 15494 02'GUA 4-4.672-4. 443-14.579 1.00 0.00 0 ATOM 15495 C3'GUA 4-3.514-6. 034-13.136 1.00 0.00 C ATOM 15496 03'GUA 4-2.407-5. 188-13.463 1.00 0. 00 0 ATOM 15497 1H5'GUA 4-2.721-9. 082-14. 550 1.00 0.00 H ATOM 15498 2H5'GUA 4-1.605-7. 914-13.813 1.00 0.00 H ATOM 15499 H4'GUA 4-3.366-6. 781-15.139 1.00 0.00 H ATOM 15500 H1'GUA 4-6.429-6. 184-14.529 1.00 0.00 H ATOM 15501 1H2 GUA 4-9.183-2. 619-12.995 1.00 0.00 H ATOM 15502 2H2 GUA 4-10. 267-2.671-11. 625 1.00 0.00 H ATOM 15503 H1 GUA 4-10.258-4. 347-10.156 1.00 0.00 H

ATOM 15504 H8 GUA 4-5.799-8. 603-11.789 1.00 0.00 H ATOM 15505 H2'GUA 4-5.127-4. 728-12.557 1.00 0.00 H ATOM 15506 H02'GUA 4-5.493-3. 953-14.665 1.00 0.00 H ATOM 15507 H3'GUA 4-3.479-6. 400-12.108 1.00 0.00 H ATOM 15508 P CYT 5-1. 930-4. 040-12.439 1.00 0.00 P ATOM 15509 01P CYT 5-2.007-4. 584-11.064 1.00 0.00 0 ATOM 15510 02P CYT 5-0.656-3. 474-12.937 1.00 0.00 0 ATOM 15511 05'CYT 5-3.079-2. 923-12.602 1.00 0.00 0 ATOM 15512 C5'CYT 5-3.068-2. 026-13. 717 1.00 0.00 C ATOM 15513 C4'CYT 5-4.058-0. 879-13. 528 1.00 0.00 C ATOM 15514 04'CYT 5-5.409-1. 347-13.449 1. 00 0.00 O ATOM 15515 C1'CYT 5-6.124-0. 583-12.457 1.00 0.00 C ATOM 15516 N1 CYT 5-6.553-1. 437-11. 327 1.00 0.00 N ATOM 15517 C6 CYT 5-5.801-2. 503-10.926 1.00 0.00 C ATOM 15518 C2 CYT 5-7. 744-1. 110-10.690 1.00 0.00 C ATOM 15519 02 CYT 5-8.407-0. 146-11.070 1.00 0.00 0 ATOM 15520 N3 CYT 5-8.150-1. 883-9.647 1.00 0.00 N ATOM 15521 C4 CYT 5-7.423-2. 932-9. 243 1.00 0.00 C ATOM 15522 N4 CYT 5-7.855-3. 665-8.218 1.00 0.00 N ATOM 15523 C5 CYT 5-6.196-3. 273-9.895 1.00 0.00 C ATOM 15524 C2'CYT 5-5.163 0.507-11. 987 1.00 0.00 C ATOM 15525 02'CYT 5-5.299 1. 700-12. 769 1.00 0.00 0 ATOM 15526 C3'CYT 5-3.822-0. 159-12.212 1.00 0.00 C ATOM 15527 03'CYT 5-2.827 0.850-12. 413 1.00 0.00 0 ATOM 15528 1H5'CYT 5-3.330-2. 576-14.620 1.00 0.00 H ATOM 15529 2H5'CYT 5-2.065-1. 613-13.830 1.00 0.00 H ATOM 15530 H4'CYT 5-3.967-0. 174-14. 353 1.00 0.00 H ATOM 15531 H1'CYT 5-6.998-0. 121-12.915 1.00 0.00 H ATOM 15532 H6 CYT 5-4. 872-2. 735-11.446 1.00 0.00 H ATOM 15533 1H4 CYT 5-8.721-3. 427-7.757 1.00 0.00 H ATOM 15534 2H4 CYT 5-7.316-4. 459-7.903 1.00 0.00 H ATOM 15535 H5 CYT 5-5.601-4. 124-9.569 1.00 0.00 H ATOM 15536 H2'CYT 5-5.315 0.713-10. 925 1.00 0.00 H ATOM 15537 H02'CYT 5-4.558 2.270-12. 550 1.00 0.00 H ATOM 15538 H3'CYT 5-3.568-0. 849-11.406 1. 00 0.00 H ATOM 15539 P URI 6-1.711 1.127-11. 285 1.00 0.00 P ATOM 15540 O1P URI 6-0.692 2.036-11. 856 1.00 0.00 O ATOM 15541 02P URI 6-1.300-0. 173-10.709 1.00 0.00 O ATOM 15542 05'URI 6-2.540 1.935-10. 166 1.00 0.00 0 ATOM 15543 C5'URI 6-2.833 3.324-10. 342 1. 00 0. 00 C ATOM 15544 C4'URI 6-3.767 3.846-9. 254 1.00 0.00 C ATOM 15545 04'URI 6-5.027 3.161-9. 259 1.00 0.00 0 ATOM 15546 C1'URI 6-5.442 2.915-7. 901 1.00 0.00 C ATOM 15547 N1 URI 6-5.447 1.466-7. 589 1.00 0.00 N ATOM 15548 C6 URI 6-4.635 0.592-8. 266 1.00 0.00 C ATOM 15549 C2 URI 6-6.301 1.030-6. 590 1.00 0.00 C ATOM 15550 02 URI 6-7.032 1.799-5. 968 1.00 0.00 0 ATOM 15551 N3 URI 6-6.284-0. 326-6.325 1.00 0.00 N ATOM 15552 C4 URI 6-5.499-1. 273-6. 959 1.00 0.00 C ATOM 15553 04 URI 6-5.568-2. 457-6.641 1.00 0.00 0 ATOM 15554 C5 URI 6-4.637-0. 733-7.984 1.00 0.00 C ATOM 15555 C2'URI 6-4.450 3.665-7. 020 1.00 0.00 C ATOM 15556 02'URI 6-4.865 5.018-6. 794 1.00 0.00 0 ATOM 15557 C3'URI 6-3.199 3. 597-7. 868 1.00 0.00 C ATOM 15558 03'URI 6-2. 340 4.686-7. 515 1.00 0.00 0 ATOM 15559 1H5'URI 6-3.305 3.469-11. 314 1.00 0.00 H ATOM 15560 2H5'URI 6-1.901 3.889-10. 310 1.00 0.00 H ATOM 15561 H4'URI 6-3.936 4.913-9. 395 1.00 0.00 H ATOM 15562 H1'URI 6-6.440 3.323-7. 746 1.00 0.00 H ATOM 15563 H6 URI 6-3.979 0.970-9. 050 1. 00 0. 00 H

ATOM 15564 H3 URI 6-6.904-0. 657-5.600 1.00 0.00 H ATOM 15565 H5 URI 6-3.973-1. 402-8.534 1.00 0.00 H ATOM 15566 H2'URI 6-4.306 3.135-6. 078 1.00 0.00 H ATOM 15567 H02'URI 6-5.610 4.991-6. 189 1.00 0.00 H ATOM 15568 H3'URI 6-2.706 2.626-7. 793 1.00 0.00 H ATOM 15569 P CYT 7-1.113 4.461-6. 494 1.00 0.00 P ATOM 15570 01P CYT 7-0.449 3.185-6. 844 1.00 0.00 0 ATOM 15571 02P CYT 7-0.324 5.712-6. 436 1.00 0.00 0 ATOM 15572 05'CYT 7-1.862 4.267-5. 081 1.00 0.00 O ATOM 15573 C5'CYT 7-2.467 5.382-4. 421 1.00 0.00 C ATOM 15574 C4'CYT 7-3.502 4.938-3. 391 1.00 0.00 C ATOM 15575 04'CYT 7-4.501 4.090-3. 972 1.00 0.00 0 ATOM 15576 C1'CYT 7-4.855 3.059-3. 026 1.00 0.00 C ATOM 15577 N1 CYT 7-4.469 1.713-3. 506 1.00 0.00 N ATOM 15578 C6 CYT 7-3.499 1.547-4. 453 1.00 0.00 C ATOM 15579 C2 CYT 7-5.112 0.626-2. 933 1.00 0.00 C ATOM 15580 02 CYT 7-5.982 0.800-2. 083 1.00 0.00 0 ATOM 15581 N3 CYT 7-4.753-0. 623-3.333 1.00 0.00 N ATOM 15582 C4 CYT 7-3.804-0. 802-4.258 1.00 0.00 C ATOM 15583 N4 CYT 7-3.475-2. 040-4.620 1.00 0.00 N ATOM 15584 C5 CYT 7-3.138 0.314-4. 856 1.00 0.00 C ATOM 15585 C2'CYT 7-4.110 3.401-1. 741 1.00 0.00 C ATOM 15586 02'CYT 7-4.875 4.281-0. 907 1.00 0.00 0 ATOM 15587 C3'CYT 7-2.882 4.087-2. 297 1.00 0.00 C ATOM 15588 03'CYT 7-2.334 4.938-1. 286 1.00 0.00 0 ATOM 15589 1H5'CYT 7-2.955 6.012-5. 165 1.00 0.00 H ATOM 15590 2H5'CYT 7-1.691 5.961-3. 919 1.00 0.00 H ATOM 15591 H4'CYT 7-3.982 5.810-2. 951 1.00 0.00 H ATOM 15592 Hl'CYT 7-5.930 3.088-2. 842 1.00 0.00 H ATOM 15593 H6 CYT 7-3.014 2.420-4. 890 1.00 0.00 H ATOM 15594 1H4 CYT 7-2.758-2. 190-5.315 1.00 0.00 H ATOM 15595 2H4 CYT 7-3.943-2. 829-4.196 1.00 0.00 H ATOM 15596 H5 CYT 7-2.365 0.171-5. 611 1.00 0.00 H ATOM 15597 H2'CYT 7-3.832 2.489-1. 206 1.00 0.00 H ATOM 15598 H02'CYT 7-4.254 4.760-0. 353 1.00 0.00 H ATOM 15599 H3'CYT 7-2.156 3.373-2. 691 1.00 0.00 H ATOM 15600 P ADE 8-1.186 4.388-0. 297 1.00 0.00 P ATOM 15601 O1P ADE 8-0.037 3.949-1. 121 1.00 0.00 0 ATOM 15602 02P ADE 8-0.983 5.385 0.778 1.00 0.00 0 ATOM 15603 05'ADE 8-1.871 3.079 0.348 1.00 0.00 0 ATOM 15604 C5'ADE 8-2.880 3.202 1.356 1.00 0.00 C ATOM 15605 C4'ADE 8-3.420 1.838 1.783 1.00 0.00 C ATOM 15606 04'ADE 8-4. 012 1.133 0.681 1.00 0.00 0 ATOM 15607 C1'ADE 8-3.554-0. 234 0.686 1.00 0.00 C ATOM 15608 N9 ADE 8-2.593-0. 481-0.409 1.00 0.00 N ATOM 15609 C4 ADE 8-2.184-1. 707-0.888 1.00 0.00 C ATOM 15610 N3 ADE 8-2.577-2. 916-0.439 1.00 0.00 N ATOM 15611 C2 ADE 8-1.993-3. 900-1.120 1.00 0.00 C ATOM 15612 N1 ADE 8-1.124-3. 778-2.125 1.00 0.00 N ATOM 15613 C6 ADE 8-0.747-2. 561-2.555 1.00 0.00 C ATOM 15614 N6 ADE 8 0.122-2. 462-3.561 1.00 0.00 N ATOM 15615 C5 ADE 8-1.299-1. 450-1.910 1.00 0. 00 C ATOM 15616 N7 ADE 8-1.135-0. 073-2.092 1.00 0.00 N ATOM 15617 C8 ADE 8-1.917 0.404-1. 184 1.00 0.00 C ATOM 15618 C2'ADE 8-2.906-0. 439 2.045 1.00 0.00 C ATOM 15619 02'ADE 8-3.876-0. 767 3.047 1.00 0.00 0 ATOM 15620 C3'ADE 8-2.304 0.929 2.274 1.00 0.00 C ATOM 15621 03'ADE 8-2.120 1.125 3. 680 1.00 0.00 0 ATOM 15622 1H5'ADE 8-3.701 3.803 0.968 1.00 0.00 H ATOM 15623 2H5'ADE 8-2.453 3.703 2.225 1.00 0.00 H

ATOM 15624 H4'ADE 8-4.162 1.966 2.570 1.00 0.00 H ATOM 15625 H1'ADE 8-4.403-0. 905 0.587 1.00 0.00 H ATOM 15626 H2 ADE 8-2.252-4. 917-0.822 1.00 0.00 H ATOM 15627 1H6 ADE 8 0.493-3. 296-3.993 1.00 0.00 H ATOM 15628 2H6 ADE 8 0.411-1. 551-3.890 1.00 0.00 H ATOM 15629 H8 ADE 8-2.028 1.478-1. 043 1.00 0.00 H ATOM 15630 H2'ADE 8-2.126-1. 200 1.983 1.00 0.00 H ATOM 15631 H02'ADE 8-3.474-0. 592 3.901 1.00 0.00 H ATOM 15632 H3'ADE 8-1.386 1.067 1.706 1.00 0.00 H ATOM 15633 P ADE 9-0.987 2.135 4.224 1.00 0.00 P ATOM 15634 01P ADE 9-1.395 3.517 3.887 1.00 0.00 O ATOM 15635 02P ADE 9-0.686 1.777 5.627 1.00 0.00 0 ATOM 15636 05'ADE 9 0.292 1.752 3.320 1.00 0.00 O ATOM 15637 C5'ADE 9 1.572 2.338 3.585 1.00 0.00 C ATOM 15638 C4'ADE 9 2.617 1.926 2.546 1.00 0.00 C ATOM 15639 04'ADE 9 2.735 0.504 2.457 1.00 0.00 0 ATOM 15640 C1'ADE 9 2.100 0.033 1.256 1.00 0.00 C ATOM 15641 N9 ADE 9 1.176-1. 077 1.560 1.00 0.00 N ATOM 15642 C4 ADE 9 1.162-2. 322 0.975 1.00 0.00 C ATOM 15643 N3 ADE 9 1.971-2. 749-0.011 1.00 0.00 N ATOM 15644 C2 ADE 9 1.699-4. 003-0.348 1.00 0. 00 C ATOM 15645 N1 ADE 9 0.763-4. 796 0.176 1.00 0.00 N ATOM 15646 C6 ADE 9-0.034-4. 348 1.160 1.00 0.00 C ATOM 15647 N6 ADE 9-0.963-5. 155 1.671 1.00 0.00 N ATOM 15648 C5 ADE 9 0.163-3. 035 1.597 1.00 0.00 C ATOM 15649 N7 ADE 9-0.464-2. 260 2.575 1.00 0.00 N ATOM 15650 C8 ADE 9 0. 185-1.149 2. 480 1.00 0.00 C ATOM 15651 C2'ADE 9 1.359 1.232 0.670 1.00 0.00 C ATOM 15652 02'ADE 9 1.296 1.170-0. 760 1.00 0.00 O ATOM 15653 C3'ADE 9 2.225 2.383 1.143 1.00 0.00 C ATOM 15654 03'ADE 9 3.397 2.428 0.308 1.00 0.00 O ATOM 15655 1H5'ADE 9 1.910 2.018 4.571 1.00 0.00 H ATOM 15656 2H5'ADE 9 1.474 3.424 3.579 1.00 0.00 H ATOM 15657 H4'ADE 9 3.581 2.349 2.819 1.00 0.00 H ATOM 15658 H1'ADE 9 2. 858.-0. 307 0.549 1.00 0.00 H ATOM 15659 H2 ADE 9 2.313-4. 434-1.133 1.00 0.00 H ATOM 15660 1H6 ADE 9-1.566-4. 826 2.411 1.00 0.00 H ATOM 15661 2H6 ADE 9-1.063-6. 096 1.319 1.00 0.00 H ATOM 15662 H8 ADE 9-0.057-0. 299 3.114 1.00 0.00 H ATOM 15663 H2'ADE 9 0.364 1.313 1.107 1.00 0.00 H ATOM 15664 H02'ADE 9 2.198 1.111-1. 083 1.00 0.00 H ATOM 15665 H3'ADE 9 1.685 3.329 1.154 1.00 0.00 H ATOM 15666 P URI 10 4.767 3.121 0.805 1.00 0.00 P ATOM 15667 01P URI 10 4.422 4.317 1.606 1.00 0.00 O ATOM 15668 02P URI 10 5.672 3.247-0. 359 1.00 0.00 0 ATOM 15669 05'URI 10 5.369 2.005 1.799 1.00 0.00 0 ATOM 15670 C5'URI 10 6.779 1. 864 1.990 1.00 0.00 C ATOM 15671 C4'URI 10 7.255 0.471 1.583 1.00 0.00 C ATOM 15672 04'URI 10 7.098 0.257 0.171 1.00 0. 00 O ATOM 15673 C1'URI 10 8.389 0.138-0. 450 1.00 0.00 C ATOM 15674 N1 URI 10 8.439 0.876-1. 733 1.00 0.00 N ATOM 15675 C6 URI 10 7.443 1. 748-2. 084 1.00 0.00 C ATOM 15676 C2 URI 10 9.529 0.657-2. 561 1.00 0.00 C ATOM 15677 02 URI 10 10. 431-0. 126-2. 268 1.00 0.00 0 ATOM 15678 N3 URI 10 9.545 1.369-3. 746 1.00 0.00 N ATOM 15679 C4 URI 10 8.583 2.267-4. 173 1.00 0.00 C ATOM 15680 04 URI 10 8.701 2.846-5. 251 1.00 0.00 O ATOM 15681 C5 URI 10 7.483 2.433-3. 251 1.00 0.00 C ATOM 15682 C2'URI 10 9.377 0.712 0.556 1.00 0.00 C ATOM 15683 02'URI 10 10.686 0.152 0.398 1.00 0.00 0

ATOM 15684 C3'URI 10 8.741 0. 288 1.864 1.00 0.00 C ATOM 15685 03'URI 10 8.995-1. 109 2.060 1.00 0.00 0 ATOM 15686 1H5'URI 10 7.012 2.024 3.043 1.00 0.00 H ATOM 15687 2H5'URI 10 7.302 2. 610 1.393 1.00 0.00 H ATOM 15688 H4'URI 10 6.685-0. 281 2.125 1.00 0.00 H ATOM 15689 HOURI 10 8.615-0. 915-0.623 1.00 0.00 H ATOM 15690 H6 URI 10 6.598 1.892-1. 411 1.00 0.00 H ATOM 15691 H3 URI 10 10.334 1.219-4. 358 1.00 0.00 H ATOM 15692 H5 URI 10 6.673 3.119-3. 497 1.00 0.00 H ATOM 15693 H2'URI 10 9.400 1.803 0.485 1.00 0.00 H ATOM 15694 H02'URI 10 11.182 0.358 1.193 1.00 0.00 H ATOM 15695 H3'URI 10 9.080 0.895 2.705 1.00 0.00 H ATOM 15696 P GUA 11 8.690-1. 817 3.476 1.00 0.00 P ATOM 15697 01P GUA 11 9.321-1. 010 4.545 1.00 0.00 0 ATOM 15698 02P GUA 11 9.014-3. 255 3.350 1.00 0.00 0 ATOM 15699 05'GUA 11 7.089-1. 675 3.607 1.00 0.00 0 ATOM 15700 C5'GUA 11 6.506-0. 874 4.642 1.00 0.00 C ATOM 15701 C4'GUA 11 5.077-1. 312 4.953 1.00 0.00 C ATOM 15702 04'GUA 11 4.224-1. 201 3.803 1.00 0.00 0 ATOM 15703 C1'GUA 11 3.477-2. 421 3.642 1.00 0.00 C ATOM 15704 N9 GUA 11 4.019-3. 233 2.540 1.00 0.00 N ATOM 15705 C4 GUA 11 3.587-4. 478 2.149 1.00 0.00 C ATOM 15706 N3 GUA 11 2.582-5. 180 2.717 1.00 0.00 N ATOM 15707 C2 GUA 11 2.391-6. 359 2.120 1.00 0.00 C ATOM 15708 N2 GUA 11 1.437-7. 180 2.557 1.00 0.00 N ATOM 15709 N1 GUA 11 3.137-6. 803 1.047 1.00 0.00 N ATOM 15710 C6 GUA 11 4.174-6. 100 0.447 1.00 0.00 C ATOM 15711 06 GUA 11 4.779-6. 585-0.504 1.00 0.00 0 ATOM 15712 C5 GUA 11 4.383-4. 845 1.076 1.00 0.00 C ATOM 15713 N7 GUA 11 5.314-3. 843 0.789 1.00 0.00 N ATOM 15714 C8 GUA 11 5.028-2. 957 1.682 1.00 0.00 C ATOM 15715 C2'GUA 11 3.608-3. 149 4.970 1.00 0.00 C ATOM 15716 02'GUA 11 2.662-2. 669 5.934 1.00 0.00 O ATOM 15717 C3'GUA 11 5.028-2. 781 5.343 1.00 0.00 C ATOM 15718 03'GUA 11 5.181-2. 888 6.759 1.00 0.00 0 ATOM 15719 1H5'GUA 11 6.496 0.169 4.324 1.00 0.00 H ATOM 15720 2H5'GUA 11 7.109-0. 965 5.546 1.00 0.00 H ATOM 15721 H4'GUA 11 4.674-0. 704 5. 762 1.00 0.00 H ATOM 15722 H1'GUA 11 2.429-2. 191 3.446 1.00 0.00 H ATOM 15723 1H2 GUA 11 1.292-8. 071 2.106 1.00 0.00 H ATOM 15724 2H2 GUA 11 0.859-6. 910 3.340 1.00 0.00 H ATOM 15725 H1 GUA 11 2.930-7. 709 0.651 1.00 0.00 H ATOM 15726 H8 GUA 11 5.580-2. 022 1.749 1.00 0.00 H ATOM 15727 H2'GUA 11 3.516-4. 229 4. 825 1.00 0.00 H ATOM 15728 H02'GUA 11 1. 791-2. 948 5.641 1.00 0.00 H ATOM 15729 H3'GUA 11 5.759-3. 376 4.793 1.00 0.00 H ATOM 15730 P CYT 12 5.990-4. 126 7.391 1.00 0.00 P ATOM 15731 01P CYT 12 7.295-4. 229 6.700 1.00 0.00 O ATOM 15732 02P CYT 12 5.943-4. 007 8.865 1.00 0.00 O ATOM 15733 05'CYT 12 5.088-5. 386 6.956 1.00 0.00 0 ATOM 15734 C5'CYT 12 3.833-5. 635 7.594 1.00 0. 00. C ATOM 15735 C4'CYT 12 3.190-6. 923 7.090 1.00 0.00 C ATOM 15736 04'CYT 12 2. 887-6. 859 5.692 1.00 0.00 0 ATOM 15737 Cl'CYT 12 3.147-8. 143 5.089 1.00 0.00 C ATOM 15738 N1 CYT 12 4.227-8. 056 4.077 1.00 0.00 N ATOM 15739 C6 CYT 12 5.001-6. 934 3.967 1.00 0.00 C ATOM 15740 C2 CYT 12 4.407-9. 145 3.232 1.00 0.00 C ATOM 15741 02 CYT 12 3. 711-10. 151 3.359 1.00 0.00 O ATOM 15742 N3 CYT 12 5.376-9. 069 2.280 1.00 0.00 N ATOM 15743 C4 CYT 12 6. 139-7. 975 2.159 1.00 0.00 C

ATOM 15744 N4 CYT 12 7.069-7. 929 1.205 1.00 0.00 N ATOM 15745 C5 CYT 12 5.962-6. 854 3.029 1.00 0.00 C ATOM 15746 C2'CYT 12 3.534-9. 077 6.234 1.00 0.00 C ATOM 15747 02'CYT 12 2.388-9. 742 6.776 1.00 0.00 0 ATOM 15748 C3'CYT 12 4.134-8. 101 7.224 1.00 0.00 C ATOM 15749 03'CYT 12 4.012-8. 637 8.544 1.00 0.00 0 ATOM 15750 1H5'CYT 12 3.161-4. 800 7.397 1.00 0.00 H ATOM 15751 2H5'CYT 12 3.993-5. 716 8.670 1.00 0.00 H ATOM 15752 H4'CYT 12 2.275-7. 120 7.648 1.00 0.00 H ATOM 15753 H1'CYT 12 2.236-8. 511 4.617 1.00 0.00 H ATOM 15754 H6 CYT 12 4.837-6. 095 4.642 1.00 0.00 H ATOM 15755 1H4 CYT 12 7.645-7. 106 1.100 1.00 0.00 H ATOM 15756 2H4 CYT 12 7.195-8. 717 0.585 1.00 0.00 H ATOM 15757 H5 CYT 12 6.584-5. 964 2.936 1.00 0.00 H ATOM 15758 H2'CYT 12 4.285-9. 795 5.900 1.00 0.00 H ATOM 15759 H02'CYT 12 1.718-9. 072 6.931 1.00 0.00 H ATOM 15760 H3'CYT 12 5.162-7. 839 6.967 1.00 0.00 H ATOM 15761 P URI 13 5.277-9. 320 9.268 1.00 0.00 P ATOM 15762 01P URI 13 4.924-9. 569 10.684 1.00 0.00 0 ATOM 15763 02P URI 13 6.485-8. 530 8.937 1.00 0.00 0 ATOM 15764 05'URI 13 5.381-10. 738 8.515 1.00 0.00 O ATOM 15765 C5'URI 13 4.409-11. 759 8.756 1.00 0.00 C ATOM 15766 C4'URI 13 4.526-12. 895 7.746 1.00 0.00 C ATOM 15767 04'URI 13 4.314-12. 439 6.406 1.00 0.00 0 ATOM 15768 C1'URI 13 5.211-13. 133 5.517 1.00 0.00 C ATOM 15769 N1 URI 13 6.154-12. 200 4.858 1.00 0.00 N ATOM 15770 C6 URI 13 6.438-10. 973 5.400 1.00 0.00 C ATOM 15771 C2 URI 13 6. 728-12. 612 3.668 1.00 0.00 C ATOM 15772 02 URI 13 6.490-13. 710 3.169 1.00 0.00 0 ATOM 15773 N3 URI 13 7.592-11. 717 3. 068 1.00 0.00 N ATOM 15774 C4 URI 13 7.929-10. 463 3.543 1.00 0.00 C ATOM 15775 04 URI 13 8.703-9. 744 2.916 1.00 0.00 O ATOM 15776 C5 URI 13 7.289-10. 113 4.790 1.00 0.00 C ATOM 15777 C2'URI 13 5.957-14. 152 6.376 1.00 0.00 C ATOM 15778 02'URI 13 5.285-15. 417 6.394 1.00 0.00 O ATOM 15779 C3'URI 13 5. 925-13. 482 7.734 1.00 0.00 C ATOM 15780 03'URI 13 6.012-14. 486 8.749 1.00 0.00 0 ATOM 15781 1H5'URI 13 3.411-11. 325 8.689 1.00 0.00 H ATOM 15782 2H5'URI 13 4.557-12. 160 9.760 1.00 0.00 H ATOM 15783 H4'URI 13 3.802-13. 674 7.981 1.00 0.00 H ATOM 15784 H1'URI 13 4.630-13. 658 4.758 1.00 0.00 H ATOM 15785 H6 URI 13 5.974-10. 683 6.343 1.00 0.00 H ATOM 15786 H3 URI 13 8.021-12. 009 2.203 1.00 0.00 H ATOM 15787 H5 URI 13 7.493-9. 145 5.246 1.00 0.00 H ATOM 15788 H2'URI 13 6.987-14. 258 6.028 1.00 0.00 H ATOM 15789 H02'URI 13 4.388-15. 259 6.698 1.00 0.00 H ATOM 15790 H3'URI 13 6.694-12. 714 7.830 1.00 0.00 H ATOM 15791 P CYT 14 7. 443-14. 912 9.353 1.00 0.00 P ATOM 15792 01P CYT 14 7.211-15. 860 10.466 1.00 0.00 0 ATOM 15793 02P CYT 14 8.235-13. 683 9.583 1.00 0.00 0 ATOM 15794 05'CYT 14 8. 112-15. 720 8.131 1.00 0.00 0 ATOM 15795 C5'CYT 14 7.718-17. 064 7.842 1.00 0.00 C ATOM 15796 C4'CYT 14 8.421-17. 601 6.598 1.00 0.00 C ATOM 15797 04'CYT 14 8.099-16. 830 5.435 1.00 0.00 0 ATOM 15798 C1'CYT 14 9.278-16. 672 4.620 1.00 0.00 C ATOM 15799 N1 CYT 14 9.691-15. 256 4.533 1.00 0.00 N ATOM 15800 C6 CYT 14 9.444-14. 386 5.555 1.00 0.00 C ATOM 15801 C2 CYT 14 10.349-14. 849 3.380 1.00 0.00 C ATOM 15802 02 CYT 14 10.568-15. 652 2.474 1.00 0.00 0 ATOM 15803 N3 CYT 14 10.745-13. 551 3.287 1.00 0.00 N

ATOM 15804 C4 CYT 14 10. 509-12.688 4. 282 1.00 0.00 C ATOM 15805 N4 CYT 14 10.911-11. 425 4.158 1.00 0.00 N ATOM 15806 C5 CYT 14 9.833-13. 102 5.472 1.00 0.00 C ATOM 15807 C2'CYT 14 10.367-17. 513 5.278 1.00 0.00 C ATOM 15808 02'CYT 14 10.396-18. 844 4.751 1.00 0.00 0 ATOM 15809 C3'CYT 14 9.930-17. 494 6.729 1.00 0.00 C ATOM 15810 03'CYT 14 10.423-18. 672 7.372 1.00 0.00 0 ATOM 15811 1H5'CYT 14 6.640-17. 094 7.682 1.00 0.00 H ATOM 15812 2H5'CYT 14 7. 969-17. 698 8.692 1.00 0.00 H ATOM 15813 H4'CYT 14 8.139-18. 639 6.433 1.00 0.00 H ATOM 15814 H1'CYT 14 9.080-17. 056 3.618 1.00 0.00 H ATOM 15815 H6 CYT 14 8.927-14. 735 6.449 1.00 0.00 H ATOM 15816 1H4 CYT 14 10.738-10. 764 4.901 1.00 0.00 H ATOM 15817 2H4 CYT 14 11.394-11. 130 3.321 1.00 0.00 H ATOM 15818 H5 CYT 14 9.646-12. 404 6.286 1.00 0.00 H ATOM 15819 H2'CYT 14 11.337-17. 022 5.168 1.00 0.00 H ATOM 15820 H02'CYT 14 9.519-19. 217 4.866 1.00 0.00 H ATOM 15821 H3'CYT 14 10.235-16. 577 7.236 1.00 0.00 H ATOM 15822 P URI 15 11.849-18. 656 8.120 1.00 0.00 P ATOM 15823 01P URI 15 11. 832-17. 572 9.127 1.00 0.00 0 ATOM 15824 02P URI 15 12.172-20. 041 8.531 1.00 0.00 0 ATOM 15825 05'URI 15 12.860-18. 230 6.940 1.00 0.00 0 ATOM 15826 C5'URI 15 13.211-19. 155 5.906 1.00 0.00 C ATOM 15827 C4'URI 15 13.995-18. 477 4.785 1.00 0.00 C ATOM 15828 04'URI 15 13.234-17. 433 4.158 1.00 0.00 0 ATOM 15829 C1'URI 15 14.080-16. 284 3.948 1. 00 0.00 C ATOM 15830 N1 URI 15 13.705-15. 167 4.844 1.00 0.00 N ATOM 15831 C6 URI 15 13.229-15. 407 6.105 1.00 0.00 C ATOM 15832 C2 URI 15 13.867-13. 878 4.367 1.00 0.00 C ATOM 15833 02 URI 15 14.297-13. 643 3.240 1.00 0.00 0 ATOM 15834 N3 URI 15 13.522-12. 861 5.238 1.00 0.00 N ATOM 15835 C4 URI 15 13.036-13. 017 6.524 1.00 0.00 C ATOM 15836 04 URI 15 12.759-12. 037 7.211 1.00 0.00 0 ATOM 15837 C5 URI 15 12.899-14. 394 6.938 1.00 0.00 C ATOM 15838 C2'URI 15 15.498-16. 758 4.238 1.00 0.00 C ATOM 15839 02'URI 15 16.107-17. 346 3.081 1.00 0.00 0 ATOM 15840 C3'URI 15 15.238-17. 785 5.319 1.00 0.00 C ATOM 15841 03'URI 15 16.317-18. 724 5.337 1.00 0.00 0 ATOM 15842 1H5'URI 15 12.301-19. 589 5.491 1.00 0.00 H ATOM 15843 2H5'URI 15 13.821-19. 951 6.334 1.00 0.00 H ATOM 15844 H4'URI 15 14.278-19. 215 4.036 1.00 0.00 H ATOM 15845 Hl'URI 15 14.007-15. 961 2.909 1.00 0.00 H ATOM 15846 H6 URI 15 13.112-16. 435 6.445 1.00 0.00 H ATOM 15847 H3 URI 15 13.634-11. 915 4.903 1.00 0.00 H ATOM 15848 H5 URI 15 12.532-14. 622 7.937 1.00 0.00 H ATOM 15849 H2'URI 15 16.102-15. 935 4.628 1. 00 0.00 H ATOM 15850 H02'URI 15 16.232-16. 644 2.437 1.00 0.00 H ATOM 15851 H3'URI 15 15.065-17. 320 6.292 1.00 0.00 H ATOM 15852 P URI 16 17.654-18. 414 6.178 1.00 0.00 P ATOM 15853 01P URI 16 18.499-19. 629 6.169 1.00 0.00 0 ATOM 15854 02P URI 16 17.259-17. 797 7.466 1.00 0.00 0 ATOM 15855 05'URI 16 18.378-17. 288 5.281 1.00 0. 00 0 ATOM 15856 C5'URI 16 19.649-16. 755 5. 668 1.00 0.00 C ATOM 15857 C4'URI 16 20.709-17. 012 4.603 1.00 0.00 C ATOM 15858 04'URI 16 20.727-18. 393 4.210 1. 00 0.00 0 ATOM 15859 C1'URI 16 20. 521-18.496 2.797 1.00 0.00 C ATOM 15860 N1 URI 16 19.734-19. 702 2. 456 1.00 0.00 N ATOM 15861 C6 URI 16 18.453-19. 864 2.914 1.00 0.00 C ATOM 15862 C2 URI 16 20.342-20. 660 1.661 1.00 0.00 C

ATOM 15863 02 URI 16 21.491-20. 533 1.241 1.00 0.00 0 ATOM 15864 N3 URI 16 19.580-21. 775 1. 365 1.00 0.00 N ATOM 15865 C4 URI 16 18. 284-22. 015 1.785 1.00 0.00 C ATOM 15866 04 URI 16 17.701-23. 047 1.459 1.00 0. 00 O ATOM 15867 C5 URI 16 17.728-20. 966 2.609 1.00 0.00 C ATOM 15868 C2'URI 16 19. 784-17. 226 2.406 1.00 0. 00 C ATOM 15869 02'URI 16 19.996-16. 893 1.028 1.00 0.00 0 ATOM 15870 C3'URI 16 20.422-16. 209 3.334 1.00 0.00 C ATOM 15871 03'URI 16 21.674-15. 796 2.776 1.00 0.00 0 ATOM 15872 1H5'URI 16 19.961-17. 214 6.601 1.00 0.00 H ATOM 15873 2H5'URI 16 19.555-15. 682 5.820 1.00 0.00 H ATOM 15874 H4'URI 16 21.688-16. 739 4.994 1.00 0.00 H ATOM 15875 Hl'URI 16 21.485-18. 529 2.288 1.00 0.00 H ATOM 15876 H6 URI 16 18.007-19. 089 3.536 1.00 0.00 H ATOM 15877 H3 URI 16 20.011-22. 482 0.786 1.00 0.00 H ATOM 15878 H5 URI 16 16.711-21. 063 2.989 1.00 0.00 H ATOM 15879 H2'URI 16 18.719-17. 321 2.631 1.00 0.00 H ATOM 15880 H02'URI 16 19.600-16. 031 0.879 1.00 0.00 H ATOM 15881 H3'URI 16 19.762-15. 363 3.528 1.00 0.00 H ATOM 15882 P CYT 17 22.529-14. 626 3.479 1.00 0.00 P ATOM 15883 01P CYT 17 22. 948-15. 096 4.819 1.00 0.00 0 ATOM 15884 02P CYT 17 23.545-14. 150 2.514 1.00 0.00 0 ATOM 15885 05'CYT 17 21.430-13. 465 3.672 1.00 0.00 0 ATOM 15886 C5'CYT 17 20.922-12. 758 2.538 1.00 0.00 C ATOM 15887 C4'CYT 17 19.908-11. 693 2.936 1.00 0.00 C ATOM 15888 04'CYT 17 18.741-12. 276 3.532 1.00 0.00 0 ATOM 15889 Cl'CYT 17 18.462-11. 605 4.759 1.00 0.00 C ATOM 15890 N1 CYT 17 17.773-12. 496 5.714 1.00 0.00 N ATOM 15891 C6 CYT 17 17.909-13. 845 5.622 1.00 0.00 C ATOM 15892 C2 CYT 17 16.980-11. 910 6.693 1.00 0. 00 C ATOM 15893 02 CYT 17 16.873-10. 686 6.754 1.00 0.00 0 ATOM 15894 N3 CYT 17 16.333-12. 727 7.569 1.00 0.00 N ATOM 15895 C4 CYT 17 16.459-14. 058 7.490 1.00 0.00 C ATOM 15896 N4 CYT 17 15.811-14. 830 8.362 1.00 0.00 N ATOM 15897 C5 CYT 17 17. 277-14. 658 6.482 1.00 0.00 C ATOM 15898 C2'CYT 17 19.821-11. 175 5.273 1.00 0.00 C ATOM 15899 02'CYT 17 19.719-10. 095 6.209 1.00 0.00 0 ATOM 15900 C3'CYT 17 20.496-10. 742 3.979 1.00 0.00 C ATOM 15901 03'CYT 17 20.067-9. 411 3.665 1.00 0.00 0 ATOM 15902 1H5'CYT 17 20.446-13. 462 1.864 1.00 0. 00 H ATOM 15903 2H5'CYT 17 21.751-12. 280 2.023 1.00 0. 00 H ATOM 15904 H4'CYT 17 19.615-11. 126 2.054 1.00 0.00 H ATOM 15905 Hl'CYT 17 17.849-10. 730 4.566 1.00 0.00 H ATOM 15906 H6 CYT 17 18.536-14. 270 4.839 1.00 0.00 H ATOM 15907 1H4 CYT 17 15.899-15. 835 8. 309 1.00 0.00 H ATOM 15908 2H4 CYT 17 15. 233-14.410 9.075 1.00 0.00 H ATOM 15909 H5 CYT 17 17.387-15. 737 6.413 1.00 0.00 H ATOM 15910 H2'CYT 17 20.350-12. 029 5.706 1.00 0.00 H ATOM 15911 H02'CYT 17 19.209-10. 413 6.958 1.00 0.00 H ATOM 15912 H3'CYT 17 21.580-10. 826 4.033 1.00 0.00 H ATOM 15913 P GUA 18 21.067-8. 369 2.950 1.00 0.00 P ATOM 15914 01P GUA 18 22.367-8. 415 3.657 1.00 0.00 O ATOM 15915 02P GUA 18 20.358-7. 080 2.795 1.00 0.00 0 ATOM 15916 05'GUA 18 21.267-9. 015 1.487 1.00 0.00 0 ATOM 15917 C5'GUA 18 20. 208-8.991 0.525 1.00 0.00 C ATOM 15918 C4'GUA 18 20.561-9. 810-0.715 1.00 0.00 C ATOM 15919 04'GUA 18 20. 823-11. 173-0.382 1.00 0.00 0 ATOM 15920 C1'GUA 18 20. 338-12. 031-1.430 1.00 0.00 C ATOM 15921 N9 GUA 18 19.375-13. 020-0. 903 1. 00 0. 00 N

ATOM 15922 C4 GUA 18 18.353-12. 786-0.008 1.00 0.00 C ATOM 15923 N3 GUA 18 18.029-11. 589 0.534 1.00 0.00 N ATOM 15924 C2 GUA 18 16.991-11. 678 1.371 1.00 0.00 C ATOM 15925 N2 GUA 18 16.545-10. 588 1.995 1.00 0.00 N ATOM 15926 N1 GUA 18 16.329-12. 857 1.648 1.00 0.00 N ATOM 15927 C6 GUA 18 16.641-14. 096 1.105 1.00 0.00 C ATOM 15928 06 GUA 18 15.989-15. 090 1.419 1.00 0.00 O ATOM 15929 C5 GUA 18 17. 743-14.012 0.214 1.00 0.00 C ATOM 15930 N7 GUA 18 18.368-15. 015-0.532 1.00 0.00 N ATOM 15931 C8 GUA 18 19.292-14. 352-1.142 1.00 0.00 C ATOM 15932 C2'GUA 18 19.691-11. 124-2.481 1.00 0.00 C ATOM 15933 02'GUA 18 20.586-10. 871-3.571 1.00 0.00 O ATOM 15934 C3'GUA 18 19.401-9. 858-1.693 1.00 0.00 C ATOM 15935 03'GUA 18 19.510-8. 735-2.576 1.00 0.00 O ATOM 15936 1H5'GUA 18 20. 018-7.960 0.228 1.00 0.00 H ATOM 15937 2H5'GUA 18 19.306-9. 403 0.978 1.00 0.00 H ATOM 15938 H4'GUA 18 21.436-9. 382-1.203 1.00 0.00 H ATOM 15939 H1'GUA 18 21.181-12. 555-1.881 1.00 0.00 H ATOM 15940 1H2 GUA 18 15.761-10. 654 2.628 1.00 0.00 H ATOM 15941 2H2 GUA 18 16.991-9. 696 1.835 1.00 0.00 H ATOM 15942 H1 GUA 18 15.553-12. 841 2.295 1.00 0.00 H ATOM 15943 H8 GUA 18 19.982-14. 847-1.826 1.00 0.00 H ATOM 15944 H2'GUA 18 18.758-11. 569-2.838 1.00 0.00 H ATOM 15945 H02'GUA 18 20.719-11. 704-4.029 1.00 0.00 H ATOM 15946 H3'GUA 18 18.436-9. 903-1.186 1.00 0.00 H ATOM 15947 P GUA 19 18.233-8. 208-3.405 1.00 0.00 P ATOM 15948 01P GUA 19 18.682-7. 126-4.309 1.00 0.00 O ATOM 15949 02P GUA 19 17.132-7. 960-2.447 1.00 0.00 O ATOM 15950 05'GUA 19 17.844-9. 487-4.306 1.00 0.00 O ATOM 15951 C5'GUA 19 16.476-9. 875-4.470 1.00 0.00 C ATOM 15952 C4'GUA 19 16.329-11. 393-4.542 1.00 0.00 C ATOM 15953 04'GUA 19 16.880-12. 032-3.376 1.00 0.00 0 ATOM 15954 C1'GUA 19 15.887-12. 892-2.795 1.00 0.00 C ATOM 15955 N9 GUA 19 15.208-12. 230-1.663 1.00 0.00 N ATOM 15956 C4 GUA 19 14.291-12. 796-0.804 1.00 0.00 C ATOM 15957 N3 GUA 19 13.861-14. 078-0.831 1.00 0.00 N ATOM 15958 C2 GUA 19 12.967-14. 331 0. 131 1.00 0.00 C ATOM 15959 N2 GUA 19 12.438-15. 549 0.247 1.00 0.00 N ATOM 15960 N1 GUA 19 12.537-13. 388 1.043 1.00 0.00 N ATOM 15961 C6 GUA 19 12.963-12. 068 1.090 1.00 0.00 C ATOM 15962 06 GUA 19 12.518-11. 306 1.943 1.00 0.00 O ATOM 15963 C5 GUA 19 13.912-11. 791 0.073 1.00 0.00 C ATOM 15964 N7 GUA 19 14.579-10. 600-0.223 1.00 0.00 N ATOM 15965 C8 GUA 19 15.302-10. 948-1.232 1.00 0.00 C ATOM 15966 C2'GUA 19 14.912-13. 171-3.923 1.00 0.00 C ATOM 15967 02'GUA 19 15.414-14. 168-4.823 1.00 0.00 O ATOM 15968 C3'GUA 19 14.860-11. 803-4.570 1.00 0.00 C ATOM 15969 03'GUA 19 14.440-11. 948-5.930 1.00 0.00 O ATOM 15970 1H5'GUA 19 16.089-9. 436-5.390 1.00 0.00 H ATOM 15971 2H5'GUA 19 15.896-9. 501-3.627 1.00 0.00 H ATOM 15972 H4'GUA 19 16.832-11. 770-5.432 1.00 0.00 H ATOM 15973 H1'GUA 19 16.348-13. 822-2.462 1.00 0.00 H ATOM 15974 1H2 GUA 19 12.712-16. 281-0.392 1.00 0. 00 H ATOM 15975 2H2 GUA 19 11.763-15. 740 0.974 1.00 0.00 H ATOM 15976 H1 GUA 19 11.859-13. 657 1.741 1.00 0.00 H ATOM 15977 H8 GUA 19 15.965-10. 236-1.722 1.00 0.00 H ATOM 15978 H2'GUA 19 13.933-13. 449-3.524 1.00 0.00 H ATOM 15979 H02'GUA 19 14.967-14. 044-5.663 1.00 0.00 H ATOM 15980 H3'GUA 19 14.230-11. 112-4.007 1.00 0.00 H

ATOM 15981 P ADE 20 12.895-11. 726-6.330 1.00 0.00 P ATOM 15982 01P ADE 20 12.411-10. 504-5.648 1.00 0.00 O ATOM 15983 02P ADE 20 12.774-11. 847-7.800 1.00 0.00 0 ATOM 15984 05'ADE 20 12.174-12. 996-5.655 1.00 0.00 0 ATOM. 15985 C5'ADE 20 12.330-14. 305-6.211 1.00 0.00 C ATOM 15986 C4'ADE 20 11.609-15. 357-5.375 1.00 0.00 C ATOM 15987 04'ADE 20 12.123-15. 412-4.034 1.00 0.00 0 ATOM 15988 C1'ADE 20 11.027-15. 424-3.101 1.00 0.00 C ATOM 15989 N9 ADE 20 10.887-14. 120-2.420 1.00 0.00 N ATOM 15990 C4 ADE 20 10.151-13. 857-1.286 1.00 0.00 C ATOM 15991 N3 ADE 20 9.408-14. 741-0.590 1.00 0.00 N ATOM 15992 C2 ADE 20 8.824-14. 163 0.455 1.00 0.00 C ATOM 15993 N1 ADE 20 8.918-12. 886 0.826 1.00 0.00 N ATOM 15994 C6 ADE 20 9.666-12. 024 0. 117 1.00 0.00 C ATOM 15995 N6 ADE 20 9.758-10. 756 0.514 1.00 0.00 N ATOM 15996 C5 ADE 20 10.328-12. 521-1.009 1.00 0.00 C ATOM 15997 N7 ADE 20 11.166-11. 923-1.953 1.00 0.00 N ATOM 15998 C8 ADE 20 11.438-12. 919-2.726 1.00 0.00 C ATOM 15999 C2'ADE 20 9.794-15. 740-3.933 1.00 0.00 C ATOM 16000 02'ADE 20 9.640-17. 150-4.137 1.00 0.00 0 ATOM 16001 C3'ADE 20 10.135-15. 019-5.218 1.00 0.00 C ATOM 16002 03'ADE 20 9.405-15. 616-6.293 1.00 0.00 0 ATOM 16003 1H5'ADE 20 13. 391-14. 551-6.255 1.00 0.00 H ATOM 16004 2H5'ADE 20 11.920-14. 312-7.221 1.00 0.00 H ATOM 16005 H4'ADE 20 11.714-16. 335-5.842 1.00 0.00 H ATOM 16006 H1'ADE 20 11.182-16. 211-2.362 1.00 0.00 H ATOM 16007 H2 ADE 20 8. 199-14.803 1.078 1.00 0.00 H ATOM 16008 1H6 ADE 20 10.326-10. 103-0.008 1.00 0.00 H ATOM 16009 2H6 ADE 20 9.263-10. 447 1.339 1.00 0.00 H ATOM 16010 H8 ADE 20 12.078-12. 797-3.598 1.00 0. 00 H ATOM 16011 H2'ADE 20 8.903-15. 306-3.472 1.00 0. 00 H ATOM 16012 H02'ADE 20 10.454-17. 471-4.532 1.00 0.00 H ATOM 16013 H3'ADE 20 9.966-13. 944-5.140 1.00 0.00 H ATOM 16014 P GUA 21 7. 954-15.048-6. 699 1.00 0.00 P ATOM 16015 O1P GUA 21 7.472-15. 806-7.875 1.00 0.00 0 ATOM 16016 02P GUA 21 8.033-13. 571-6.755 1.00 0.00 O ATOM 16017 05'GUA 21 7.054-15. 455-5.428 1.00 0.00 0 ATOM 16018 C5'GUA 21 6.598-16. 801-5.262 1.00 0.00 C ATOM 16019 C4'GUA 21 5.634-16. 925-4.086 1.00 0.00 C ATOM 16020 04'GUA 21 6.273-16. 626-2. 837 1.00 0.00 0 ATOM 16021 C1'GUA 21 5.401-15. 804-2.037 1.00 0.00 C ATOM 16022 N9 GUA 21 5.938-14. 434-1.902 1.00 0. 00 N ATOM 16023 C4 GUA 21 5.639-13. 529-0.908 1.00 0.00 C ATOM 16024 N3 GUA 21 4.764-13. 722 0.105 1.00 0.00 N ATOM 16025 C2 GUA 21 4.685-12. 661 0.914 1. 00 0.00 C ATOM 16026 N2 GUA 21 3.856-12. 677 1.957 1. 00 0.00 N ATOM 16027 N1 GUA 21 5.417-11. 505 0.733 1.00 0.00 N ATOM 16028 C6 GUA 21 6.321-11. 283-0.297 1.00 0.00 C ATOM 16029 06 GUA 21 6.933-10. 220-0.361 1.00 0.00 O ATOM 16030 C5 GUA 21 6.409-12. 404-1.163 1.00 0.00 C ATOM 16031 N7 GUA 21 7.187-12. 590-2.309 1.00 0.00 N ATOM 16032 C8 GUA 21 6.850-13. 782-2.666 1.00 0.00 C ATOM 16033 C2'GUA 21 4.057-15. 805-2.756 1.00 0.00 C ATOM 16034 02'GUA 21 3.250-16. 922-2.362 1.00 0.00 O ATOM 16035 C3'GUA 21 4.503-15. 918-4.198 1.00 0.00 C ATOM 16036 03'GUA 21 3.448-16. 498-4.971 1.00 0.00 O ATOM 16037 1H5'GUA 21 7.456-17. 450-5.089 1.00 0. 00 H ATOM 16038 2H5'GUA 21 6.089-17. 118-6.172 1.00 0.00 H ATOM 16039 H4'GUA 21 5.226-17. 934-4.050 1.00 0. 00 H

ATOM 16040 Hl'GUA 21 5.286-16. 250-1. 048 1. 00 0.00 H ATOM 16041 1H2 GUA 21 3. 287-13. 492 2.137 1.00 0.00 H ATOM 16042 2H2 GUA 21 3.792-11. 873 2.565 1.00 0.00 H ATOM 16043 Hl GUA 21 5.302-10. 748 1.390 1.00 0.00 H ATOM 16044 H8 GUA 21 7.273-14. 245-3.556 1.00 0.00 H ATOM 16045 H2'GUA 21 3.536-14. 861-2. 588 1.00 0.00 H ATOM 16046 H02'GUA 21 3.757-17. 718-2.541 1.00 0.00 H ATOM 16047 H3'GUA 21 4.842-14. 961-4.597 1.00 0.00 H ATOM 16048 P ADE 22 2.416-15. 560-5. 777 1.00 0.00 P ATOM 16049 O1P ADE 22 1.675-16. 406-6.739 1. 00 0.00 0 ATOM 16050 02P ADE 22 3.149-14. 367-6.256 1.00 0.00 0 ATOM 16051 05'ADE 22 1.395-15. 093-4.624 1.00 0.00 0 ATOM 16052 C5'ADE 22 0.526-16. 043-4.001 1.00 0.00 C ATOM 16053 C4'ADE 22 0.002-15. 534-2.661 1.00 0.00 C ATOM 16054 04'ADE 22 1.071-15. 184-1.774 1.00 0.00 0 ATOM 16055 C1'ADE 22 0.734-13. 973-1.071 1.00 0.00 C ATOM 16056 N9 ADE 22 1.625-12. 860-1.457 1.00 0.00 N ATOM 16057 C4 ADE 22 1.914-11. 744-0.706 1.00 0.00 C ATOM 16058 N3 ADE 22 1.425-11. 455 0.516 1.00 0.00 N ATOM 16059 C2 ADE 22 1.903-10. 301 0.967 1.00 0.00 C ATOM 16060 N1 ADE 22 2.758-9. 485 0.347 1.00 0. 00 N ATOM 16061 C6 ADE 22 3.233-9. 797-0.872 1.00 0.00 C ATOM 16062 N6 ADE 22 4.090-8. 973-1.472 1.00 0.00 N ATOM 16063 C5 ADE 22 2.795-10. 992-1.447 1.00 0.00 C ATOM 16064 N7 ADE 22 3.073-11. 612-2.669 1.00 0.00 N ATOM 16065 C8 ADE 22 2.355-12. 680-2.587 1.00 0.00 C ATOM 16066 C2'ADE 22-0.715-13. 667-1.432 1.00 0.00 C ATOM 16067 02'ADE 22-1.623-14. 307-0.529 1.00 0.00 0 ATOM 16068 C3'ADE 22-0. 802-14.256-2. 825 1.00 0.00 C ATOM 16069 03'ADE 22-2.164-14. 603-3.098 1.00 0.00 0 ATOM 16070 1H5'ADE 22 1.072-16. 972-3.837 1.00 0.00 H ATOM 16071 2H5'ADE 22-0. 319-16.238-4. 662 1.00 0.00 H ATOM 16072 H4'ADE 22-0.617-16. 299-2.194 1. 00 0.00 H ATOM 16073 H1'ADE 22 0.811-14. 145 0.003 1.00 0.00 H ATOM 16074 H2 ADE 22 1.555-9. 985 1.951 1.00 0.00 H ATOM 16075 1H6 ADE 22 4.455-9. 202-2.386 1.00 0. 00 H ATOM 16076 2H6 ADE 22 4.377-8. 119-1.014 1.00 0.00 H ATOM 16077 H8 ADE 22 2.329-13. 406-3.398 1.00 0.00 H ATOM 16078 H2'ADE 22-0.880-12. 587-1.461 1.00 0.00 H ATOM 16079 H02'ADE 22-1.371-15. 232-0. 477 1.00 0.00 H ATOM 16080 H3'ADE 22-0. 374-13. 592-3.578 1.00 0.00 H ATOM 16081 P CYT 23-3.209-13. 488-3. 610 1.00 0.00 P ATOM 16082 01P CYT 23-4.477-14. 167-3.958 1.00 0. 00 O ATOM 16083 02P CYT 23-2.527-12. 639-4.613 1.00 0.00 0 ATOM 16084 05'CYT 23-3. 456-12. 604-2.286 1.00 0.00 0 ATOM 16085 C5'CYT 23-4.081-13. 179-1.134 1.00 0.00 C ATOM 16086 C4'CYT 23-4.023-12. 240 0.069 1.00 0.00 C ATOM 16087 04'CYT 23-2.685-11. 857 0.379 1.00 0.00 0 ATOM 16088 C1'CYT 23-2.690-10. 535 0.950 1.00 0.00 C ATOM 16089 N1 CYT 23-1.731-9. 646 0.256 1.00 0.00 N ATOM 16090 C6 CYT 23-1.423-9. 832-1.061 1.00 0.00 C ATOM 16091 C2 CYT 23-1.152-8. 623 0.997 1.00 0.00 C ATOM 16092 02 CYT 23-1.448-8. 471 2.181 1.00 0.00 0 ATOM 16093 N3 CYT 23-0.260-7. 803 0.378 1.00 0.00 N ATOM 16094 C4 CYT 23 0.053-7. 974-0. 911 1.00 0.00 C ATOM 16095 N4 CYT 23 0.936-7. 155-1.482 1.00 0.00 N ATOM 16096 C5 CYT 23-0.541-9. 024-1.680 1.00 0.00 C ATOM 16097 C2'CYT 23-4.125-10. 007 0.828 1.00 0.00 C ATOM 16098 02'CYT 23-4.821-10. 093 2. 076 1.00 0. 00 0

ATOM 16099 C3'CYT 23-4.733-10. 933-0.215 1.00 0.00 C ATOM 16100 03'CYT 23-6.126-11. 108 0.074 1.00 0.00 O ATOM 16101 1H5'CYT 23-3.573-14. 110-0.882 1.00 0.00 H ATOM 16102 2H5'CYT 23-5.124-13. 394-1.366 1.00 0.00 H ATOM 16103 H4'CYT 23-4.471-12. 722 0.936 1.00 0.00 H ATOM 16104 H1'CYT 23-2.420-10. 600 2.005 1.00 0.00 H ATOM 16105 H6 CYT 23-1.897-10. 640-1.618 1.00 0.00 H ATOM 16106 1H4 CYT 23 1.184-7. 276-2.453 1.00 0.00 H ATOM 16107 2H4 CYT 23 1.357-6. 411-0.942 1.00 0.00 H ATOM 16108 H5 CYT 23-0.290-9. 163-2.731 1.00 0.00 H ATOM 16109 H2'CYT 23-4.115-8. 978 0.458 1.00 0.00 H ATOM 16110 H02'CYT 23-5.728-9. 825 1.915 1.00 0.00 H ATOM 16111 H3'CYT 23-4.555-10. 579-1.231 1.00 0.00 H ATOM 16112 P GUA 24-7.209-10. 004-0. 377 1.00 0.00 P ATOM 16113 O1P GUA 24-6.739-9. 375-1.632 1.00 0.00 O ATOM 16114 02P GUA 24-8.552-10. 624-0.321 1.00 0.00 O ATOM 16115 05'GUA 24-7.106-8. 912 0.800 1.00 0.00 O ATOM 16116 C5'GUA 24-7.828-9. 081 2.024 1.00 0.00 C ATOM 16117 C4'GUA 24-8. 198-7.736 2.640 1.00 0.00 C ATOM 16118 04'GUA 24-7.030-6. 941 2.911 1.00 0.00 O ATOM 16119 Cl'GUA 24-7.208-5. 630 2.349 1.00 0.00 C ATOM 16120 N9 GUA 24-6.460-5. 479 1.088 1.00 0.00 N ATOM 16121 C4 GUA 24-6. 288-4.314 0.383 1.00 0.00 C ATOM 16122 N3 GUA 24-6.782-3. 105 0.729 1.00 0.00 N ATOM 16123 C2 GUA 24-6.452-2. 158-0.150 1.00 0.00 C ATOM 16124 N2 GUA 24-6.863-0. 904 0.038 1.00 0.00 N ATOM 16125 N1 GUA 24-5.693-2. 393-1.278 1.00 0.00 N ATOM 16126 C6 GUA 24-5.177-3. 625-1.654 1.00 0.00 C ATOM 16127 06 GUA 24-4. 516-3. 729-2. 685 1.00 0.00 0 ATOM 16128 C5 GUA 24-5.523-4. 639-0.725 1.00 0.00 C ATOM 16129 N7 GUA 24-5.209-6. 001-0.724 1.00 0.00 N ATOM 16130 C8 GUA 24-5.790-6. 402 0.356 1.00 0.00 C ATOM 16131 C2'GUA 24-8.703-5. 497 2.115 1.00 0.00 C ATOM 16132 02'GUA 24-9.397-5. 136 3.315 1.00 0.00 0 ATOM 16133 C3'GUA 24-9.034-6. 906 1.674 1.00 0.00 C ATOM 16134 03'GUA 24-10.420-7. 162 1.925 1.00 0.00 0 ATOM 16135 1H5'GUA 24-7.211-9. 639 2.729 1.00 0.00 H ATOM 16136 2H5'GUA 24-8. 740-9.645 1. 826 1.00 0.00 H ATOM 16137 H4'GUA 24-8.751-7. 894 3.565 1.00 0.00 H ATOM 16138 Hl'GUA 24-6.879-4. 872 3.059 1.00 0.00 H ATOM 16139 1H2 GUA 24-7.424-0. 672 0. 845 1.00 0.00 H ATOM 16140 2H2 GUA 24-6.614-0. 186-0. 626 1.00 0.00 H ATOM 16141 H1 GUA 24-5.484-1. 623-1.890 1.00 0.00 H ATOM 16142 H8 GUA 24-5.744-7. 446 0.668 1.00 0.00 H ATOM 16143 H2'GUA 24-8.900-4. 785 1.311 1.00 0.00 H ATOM 16144 H02'GUA 24-9. 189-4. 217 3.499 1.00 0.00 H ATOM 16145 H3'GUA 24-8.755-7. 083 0.634 1.00 0.00 H ATOM 16146 P ADE 25-11.489-7. 100 0.721 1.00 0.00 P ATOM 16147 01P ADE 25-12.771-7. 652 1.212 1.00 0.00 O ATOM 16148 02P ADE 25-10.858-7. 668-0.492 1.00 0.00 0 ATOM 16149 05'ADE 25-11.672-5. 516 0.499 1.00 0.00 O ATOM 16150 C5'ADE 25-12.482-4. 747 1.393 1.00 0.00 C ATOM 16151 C4'ADE 25-12.432-3. 258 1.060 1. 00 0. 00 C ATOM 16152 04'ADE 25-11.098-2. 739 1.156 1.00 0.00 0 ATOM 16153 C1'ADE 25-10.835-1. 883 0.027 1.00 0.00 C ATOM 16154 N9 ADE 25-9.879-2. 507-0.909 1.00 0.00 N ATOM 16155 C4 ADE 25-9.186-1. 874-1.915 1.00 0.00 C ATOM 16156 N3 ADE 25-9.244-0. 564-2.224 1.00 0.00 N ATOM 16157 C2 ADE 25-8.451-0. 274-3.251 1.00 0.00 C

ATOM 16158 N1 ADE 25-7.673-1. 117-3.932 1.00 0.00 N ATOM 16159 C6 ADE 25-7.633-2. 420-3.604 1.00 0.00 C ATOM 16160 N6 ADE 25-6.851-3. 246-4.296 1.00 0.00 N ATOM 16161 C5 ADE 25-8.430-2. 841-2.536 1.00 0.00 C ATOM 16162 N7 ADE 25-8.630-4. 089-1.938 1.00 0.00 N ATOM 16163 C8 ADE 25-9.480-3. 799-1.011 1.00 0.00 C ATOM 16164 C2'ADE 25-12.183-1. 665-0.645 1.00 0.00 C ATOM 16165 02'ADE 25-12.903-0. 581-0.045 1.00 0.00 0 ATOM 16166 C3'ADE 25-12.850-2. 997-0.378 1.00 0.00 C ATOM 16167 03'ADE 25-14.268-2. 821-0.428 1.00 0.00 O ATOM 16168 1H5'ADE 25-12.126-4. 895 2.413 1.00 0.00 H ATOM 16169 2H5'ADE 25-13.514-5. 092 1.322 1.00 0.00 H ATOM 16170 H4'ADE 25-13.083-2. 708 1.737 1.00 0.00 H ATOM 16171 H1'ADE 25-10. 439-0.929 0.374 1.00 0.00 H ATOM 16172 H2 ADE 25-8.436 0.768-3. 572 1.00 0.00 H ATOM 16173 1H6 ADE 25-6.815-4. 227-4.056 1.00 0.00 H ATOM 16174 2H6 ADE 25-6.294-2. 893-5.061 1.00 0.00 H ATOM 16175 H8 ADE 25-9.864-4. 564-0.338 1.00 0.00 H ATOM 16176 H2'ADE 25-12.053-1. 509-1.719 1.00 0.00 H ATOM 16177 H02'ADE 25-12.967-0. 767 0.895 1.00 0.00 H ATOM 16178 H3'ADE 25-12.496-3. 774-1.058 1.00 0.00 H ATOM 16179 P CYT 26-15.046-2. 901-1.836 1.00 0.00 P ATOM 16180 01P CYT 26-16.483-2. 653-1.586 1.00 0.00 0 ATOM 16181 02P CYT 26-14. 621-4. 137-2.531 1.00 0.00 0 ATOM 16182 05'CYT 26-14. 445-1. 642-2.641 1.00 0.00 0 ATOM 16183 C5'CYT 26-14.912-0. 315-2.376 1.00 0. 00 C ATOM 16184 C4'CYT 26-14.335 0.692-3. 367 1.00 0.00 C ATOM 16185 04'CYT 26-12.907 0.795-3. 257 1.00 0.00 0 ATOM 16186 C1'CYT 26-12. 326 0.823-4. 577 1.00 0.00 C ATOM 16187 N1 CYT 26-11.597-0. 432-4. 866 1.00 0.00 N ATOM 16188 C6 CYT 26-12.048-1. 627-4.389 1.00 0.00 C ATOM 16189 C2 CYT 26-10.444-0. 349-5.637 1.00 0.00 C ATOM 16190 02 CYT 26-10.055 0.740-6. 055 1.00 0.00 O ATOM 16191 N3 CYT 26-9.767-1. 498-5.908 1.00 0.00 N ATOM 16192 C4 CYT 26-10.200-2. 677-5.445 1.00 0.00 C ATOM 16193 N4 CYT 26-9.508-3. 782-5.720 1.00 0.00 N ATOM 16194 C5 CYT 26-11.387-2. 765-4.653 1.00 0.00 C ATOM 16195 C2'CYT 26-13.496 1.012-5. 535 1.00 0.00 C ATOM 16196 02'CYT 26-13.826 2.397-5. 699 1.00 0.00 0 ATOM 16197 C3'CYT 26-14.584 0.257-4. 802 1.00 0.00 C ATOM 16198 03'CYT 26-15.862 0.751-5. 215 1.00 0.00 0 ATOM 16199 lH5'CYT 26-14.618-0. 028-1.366 1.00 0.00 H ATOM 16200 2H5'CYT 26-15.999-0. 301-2.448 1.00 0. 00 H ATOM 16201 H4'CYT 26-14.781 1.671-3. 198 1.00 0.00 H ATOM 16202 H1'CYT 26-11.646 1.671-4. 659 1.00 0.00 H ATOM 16203 H6 CYT 26-12.954-1. 660-3. 784 1.00 0.00 H ATOM 16204 1H4 CYT 26-9.823-4. 676-5.371 1.00 0.00 H ATOM 16205 2H4 CYT 26-8.666-3. 726-6.274 1.00 0.00 H ATOM 16206 H5 CYT 26-11.751-3. 722-4.285 1.00 0.00 H ATOM 16207 H2'CYT 26-13.279 0.540-6. 497 1.00 0.00 H ATOM 16208 H02'CYT 26-13.114 2.803-6. 198 1.00 0.00 H ATOM 16209 H3'CYT 26-14.487-0. 824-4.927 1.00 0.00 H ATOM 16210 P CYT 27-16. 985-0. 259-5.778 1.00 0.00 P ATOM 16211 01P CYT 27-16.806-1. 571-5.115 1.00 0.00 0 ATOM 16212 02P CYT 27-18.295 0.426-5. 719 1. 00 0.00 0 ATOM 16213 05'CYT 27-16.566-0. 416-7.325 1.00 0.00 0 ATOM 16214 C5'CYT 27-16.488 0.734-8. 172 1.00 0.00 C ATOM 16215 C4'CYT 27-15.304 0.649-9. 131 1.00 0.00 C ATOM 16216 04'CYT 27-14. 083 0.362-8. 443 1.00 0.00 O ATOM 16217 C1'CYT 27-13.235-0. 428-9.303 1.00 0.00 C

ATOM 16218 N1 CYT 27-12.863-1. 722-8.684 1.00 0.00 N ATOM 16219 C6 CYT 27-13.560-2. 236-7.626 1.00 0.00 C ATOM 16220 C2 CYT 27-11. 790-2.402-9. 242 1.00 0.00 C ATOM 16221 02 CYT 27-11.184-1. 922-10.196 1.00 0.00 O ATOM 16222 N3 CYT 27-11.440-3. 604-8.713 1. 00 0. 00 N ATOM 16223 C4 CYT 27-12.112-4. 124-7. 680 1.00 0.00 C ATOM 16224 N4 CYT 27-11.736-5. 303-7.188 1.00 0.00 N ATOM 16225 C5 CYT 27-13.220-3. 431-7.097 1.00 0.00 C ATOM 16226 C2'CYT 27-14.026-0. 658-10.591 1.00 0.00 C ATOM 16227 02'CYT 27-13.694 0.312-11. 591 1.00 0.00 0 ATOM 16228 C3'CYT 27-15.453-0. 499-10.108 1.00 0.00 C ATOM 16229 03'CYT 27-16.267-0. 076-11.207 1.00 0.00 0 ATOM 16230 1H5'CYT 27-16.378 1.625-7. 553 1.00 0.00 H ATOM 16231 2H5'CYT 27-17.409 0.814-8. 749 1.00 0.00 H ATOM 16232 H4'CYT 27-15.200 1.586-9. 674 1.00 0.00 H ATOM 16233 H1'CYT 27-12.331 0.137-9. 532 1.00 0.00 H ATOM 16234 H6 CYT 27-14.393-1. 675-7.202 1.00 0.00 H ATOM 16235 1H4 CYT 27-12.231-5. 706-6.406 1.00 0.00 H ATOM 16236 2H4 CYT 27-10. 957-5. 796-7.601 1.00 0.00 H ATOM 16237 H5 CYT 27-13.776-3. 861-6.262 1.00 0.00 H ATOM 16238 H2'CYT 27-13.861-1. 673-10.957 1.00 0.00 H ATOM 16239 H02'CYT 27-12.808 0.109-11. 903 1.00 0.00 H ATOM 16240 H3'CYT 27-15.827-1. 405-9.627 1.00 0.00 H ATOM 16241 P GUA 28-16.801-1. 146-12.288 1.00 0.00 P ATOM 16242 01P GUA 28-17.123-2. 403-11. 577 1.00 0.00 0 ATOM 16243 02P GUA 28-17.833-0. 486-13.120 1.00 0.00 0 ATOM 16244 05'GUA 28-15.501-1. 405-13.206 1. 00 0.00 0 ATOM 16245 C5'GUA 28-15.134-0. 473-14.228 1.00 0.00 C ATOM 16246 C4'GUA 28-14.043-1. 031-15.140 1.00 0.00 C ATOM 16247 04'GUA 28-12. 842-1.326-14. 417 1.00 0.00 0 ATOM 16248 C1'GUA 28-12.267-2. 549-14.921 1.00 0.00 C ATOM 16249 N9 GUA 28-12.285-3. 611-13.894 1.00 0.00 N ATOM 16250 C4 GUA 28-11.572-4. 790-13.917 1.00 0.00 C ATOM 16251 N3 GUA 28-10.737-5. 193-14.901 1.00 0.00 N ATOM 16252 C2 GUA 28-10.188-6. 383-14.641 1.00 0.00 C ATOM 16253 N2 GUA 28-9. 347-6.934-15. 517 1.00 0.00 N ATOM 16254 N1 GUA 28-10.446-7. 112-13.497 1.00 0.00 N ATOM 16255 C6 GUA 28-11.299-6. 720-12.475 1. 00 0. 00 C ATOM 16256 06 GUA 28-11.458-7. 442-11.494 1.00 0.00 0 ATOM 16257 C5 GUA 28-11.888-5. 456-12.743 1.00 0. 00 C ATOM 16258 N7 GUA 28-12.793-4. 712-11.982 1.00 0. 00 N ATOM 16259 C8 GUA 28-12.964-3. 669-12.723 1.00 0.00 C ATOM 16260 C2'GUA 28-13.110-2. 941-16.131 1.00 0.00 C ATOM 16261 02'GUA 28-12.600-2. 358-17.336 1.00 0.00 O ATOM 16262 C3'GUA 28-14.455-2. 357-15.754 1.00 0.00 C ATOM 16263 03'GUA 28-15.199-2. 103-16.950 1.00 0.00 0 ATOM 16264 lH5'GUA 28-14.772 0.443-13. 761 1.00 0.00 H ATOM 16265 2H5'GUA 28-16.014-0. 242-14.829 1.00 0.00 H ATOM 16266 H4'GUA 28-13.822-0. 314-15.929 1.00 0.00 H ATOM 16267 H1'GUA 28-11. 240-2. 365-15.238 1.00 0.00 H ATOM 16268 1H2 GUA 28-9.125-6. 451-16.376 1.00 0.00 H ATOM 16269 2H2 GUA 28-8.931-7. 833-15.321 1.00 0.00 H ATOM 16270 Hl GUA 28-9.986-8. 002-13.372 1.00 0.00 H ATOM 16271 H8 GUA 28-13.638-2. 869-12.424 1.00 0.00 H ATOM 16272 H2'GUA 28-13.173-4. 028-16.214 1.00 0.00 H ATOM 16273 H02'GUA 28-13.337-2. 270-17.944 1.00 0.00 H ATOM 16274 H3'GUA 28-14.993-2. 990-15.047 1.00 0.00 H ATOM 16275 P CYT 29-16. 182-3. 229-17. 552 1.00 0.00 P ATOM 16276 01P CYT 29-17.030-3. 740-16.452 1.00 0.00 O ATOM 16277 02P CYT 29-16.811-2. 687-18.777 1. 00 0.00 O

ATOM 16278 05'CYT 29-15.159-4. 397-17.982 1.00 0.00 O ATOM 16279 C5'CYT 29-14.411-4. 303-19.199 1.00 0.00 C ATOM 16280 C4'CYT 29-13.499-5. 511-19.394 1.00 0.00 C ATOM 16281 04'CYT 29-12.554-5. 639-18.323 1.00 0.00 0 ATOM 16282 C1'CYT 29-12.444-7. 025-17.940 1.00 0.00 C ATOM 16283 N1 CYT 29-12.994-7. 254-16.584 1.00 0.00 N ATOM 16284 C6 CYT 29-13.972-6. 448-16.076 1.00 0.00 C ATOM 16285 C2 CYT 29-12.470-8. 308-15.846 1.00 0.00 C ATOM 16286 02 CYT 29-11.596-9. 027-16.326 1.00 0.00 O ATOM 16287 N3 CYT 29-12.952-8. 519-14.591 1.00 0.00 N ATOM 16288 C4 CYT 29-13.909-7. 734-14.080 1.00 0.00 C ATOM 16289 N4 CYT 29-14.351-7. 964-12.844 1.00 0.00 N ATOM 16290 C5 CYT 29-14.455-6. 650-14.836 1.00 0.00 C ATOM 16291 C2'CYT 29-13.222-7. 810-18.990 1.00 0.00 C ATOM 16292 02'CYT 29-12.394-8. 158-20.107 1.00 0.00 O ATOM 16293 C3'CYT 29-14.289-6. 808-19.377 1.00 0.00 C ATOM 16294 03'CYT 29-14.733-7. 094-20.707 1.00 0.00 0 ATOM 16295 1H5'CYT 29-13.803-3. 398-19.176 1.00 0.00 H ATOM 16296 2H5'CYT 29-15.105-4. 243-20.038 1.00 0.00 H ATOM 16297 H4'CYT 29-12.964-5. 420-20.338 1.00 0.00 H ATOM 16298 H1'CYT 29-11.396-7. 326-17.964 1.00 0.00 H ATOM 16299 H6 CYT 29-14.369-5. 633-16.682 1.00 0.00 H ATOM 16300 1H4 CYT 29-15.068-7. 374-12.446 1.00 0.00 H ATOM 16301 2H4 CYT 29-13.968-8. 728-12.305 1.00 0. 00 H ATOM 16302 H5 CYT 29-15.234-6. 011-14. 423 1.00 0.00 H ATOM 16303 H2'CYT 29-13.674-8. 698-18.542 1.00 0.00 H ATOM 16304 H02'CYT 29-12.036-7. 342-20.463 1.00 0.00 H ATOM 16305 H3'CYT 29-15.107-6. 783-18.655 1.00 0.00 H ATOM 16306 P CYT 30-15.987-8. 073-20.957 1.00 0.00 P ATOM 16307 O1P CYT 30-16.266-8. 105-22.409 1.00 0.00 O ATOM 16308 02P CYT 30-17.061-7. 703-20.007 1.00 0.00 O ATOM 16309 05'CYT 30-15.404-9. 509-20.521 1.00 0.00 O ATOM 16310 C5'CYT 30-14.456-10. 193-21.348 1.00 0.00 C ATOM 16311 C4'CYT 30-13.837-11. 386-20. 624 1. 00 0.00 C ATOM 16312 04'CYT 30-13.179-10. 988-19. 418 1.00 0.00 0 ATOM 16313 C1'CYT 30-13.394-11. 990-18.408 1.00 0.00 C ATOM 16314 N1 CYT 30-14.158-11. 447-17.262 1.00 0.00 N ATOM 16315 C6 CYT 30-15.074-10. 448-17.432 1.00 0.00 C ATOM 16316 C2 CYT 30-13.902-11. 988-16.009 1.00 0. 00 C ATOM 16317 02 CYT 30-13.079-12. 892-15.880 1.00 0.00 O ATOM 16318 N3 CYT 30-14.589-11. 497-14.942 1.00 0.00 N ATOM 16319 C4 CYT 30-15.490-10. 519-15.093 1.00 0. 00 C ATOM 16320 N4 CYT 30-16.145-10. 063-14.026 1.00 0.00 N ATOM 16321 C5 CYT 30-15.758-9. 958-16.381 1.00 0.00 C ATOM 16322 C2'CYT 30-14.155-13. 123-19.094 1.00 0.00 C ATOM 16323 02'CYT 30-13.258-14. 097-19.643 1.00 0.00 0 ATOM 16324 C3'CYT 30-14.899-12. 377-20.182 1.00 0.00 C ATOM 16325 03'CYT 30-15.299-13. 245-21.248 1.00 0.00 O ATOM 16326 1H5'CYT 30-13.664-9. 499-21.631 1.00 0.00 H ATOM 16327 2H5'CYT 30-14.959-10. 545-22.249 1.00 0.00 H ATOM 16328 H4'CYT 30-13.122-11. 882-21.278 1.00 0.00 H ATOM 16329 H1'CYT 30-12.430-12. 362-18.059 1.00 0.00 H ATOM 16330 H6 CYT 30-15.257-10. 047-18.429 1.00 0.00 H ATOM 16331 1H4 CYT 30-16.826-9. 324-14.128 1.00 0.00 H ATOM 16332 2H4 CYT 30-15.964-10. 461-13.115 1.00 0.00 H ATOM 16333 H5 CYT 30-16.490-9. 160-16.508 1.00 0. 00 H ATOM 16334 H2'CYT 30-14.859-13. 585-18.397 1.00 0.00 H ATOM 16335 H02'CYT 30-12.793-14. 502-18.907 1.00 0.00 H ATOM 16336 H3'CYT 30-15.757-11. 848-19.755 1.00 0.00 H ATOM 16337 H03'CYT 30-14.534-13. 772-21.489 1.00 0.00 H

TER ATOM 16338 05'GUA 1 7.294-3. 684-23.616 1.00 0.00 0 ATOM 16339 C5'GUA 1 6.473-3. 571-24.781 1.00 0.00 C ATOM 16340 C4'GUA 1 6.024-4. 939-25.289 1.00 0.00 C ATOM 16341 04'GUA 1 7.144-5. 801-25.546 1.00 0.00 0 ATOM 16342 C1'GUA 1 6. 879-7. 109-25.002 1.00 0.00 C ATOM 16343 N9 GUA 1 7.696-7. 366-23.798 1.00 0.00 N ATOM 16344 C4 GUA 1 7.991-8. 596-23.253 1.00 0.00 C ATOM 16345 N3 GUA 1 7.582-9. 795-23.728 1.00 0.00 N ATOM 16346 C2 GUA 1 8.028-10. 811-22.984 1.00 0.00 C ATOM 16347 N2 GUA 1 7.708-12. 064-23.307 1.00 0.00 N ATOM 16348 N1 GUA 1 8.815-10. 651-21.862 1.00 0.00 N ATOM 16349 C6 GUA 1 9.247-9. 433-21.355 1.00 0.00 C ATOM 16350 06 GUA 1 9.947-9. 399-20.345 1.00 0.00 O ATOM 16351 C5 GUA 1 8.778-8. 347-22.138 1.00 0.00 C ATOM 16352 N7 GUA 1 8.981-6. 974-21.976 1.00 0.00 N ATOM 16353 C8 GUA 1 8.322-6. 491-22.974 1.00 0.00 C ATOM 16354 C2'GUA 1 5.396-7. 115-24.663 1.00 0.00 C ATOM 16355 02'GUA 1 4.597-7. 458-25.802 1.00 0.00 0 ATOM 16356 C3'GUA 1 5.195-5. 673-24.247 1.00 0.00 C ATOM 16357 03'GUA 1 3.817-5. 328-24.424 1.00 0.00 O ATOM 16358 H5'GUA 1 8.176-3. 921-23.912 1.00 0.00 H ATOM 16359 1H5'GUA 1 7.038-3. 069-25.566 1.00 0.00 H ATOM 16360 2H5'GUA 1 5.593-2. 975-24.539 1.00 0.00 H ATOM 16361 H4'GUA 1 5.444-4. 821-26.203 1.00 0.00 H ATOM 16362 Hl'GUA 1 7.085-7. 868-25.756 1.00 0.00 H ATOM 16363 1H2 GUA 1 7.129-12. 245-24.114 1.00 0.00 H ATOM 16364 2H2 GUA 1 8.045-12. 832-22.744 1.00 0.00 H ATOM 16365 H1 GUA 1 9.112-11. 470-21.355 1.00 0.00 H ATOM 16366 H8 GUA 1 8.265-5. 418-23.144 1.00 0.00 H ATOM 16367 H2'GUA 1 5.200-7. 788-23.825 1.00 0.00 H ATOM 16368 H02'GUA 1 4.720-8. 396-25.964 1.00 0.00 H ATOM 16369 H3'GUA 1 5.550-5. 487-23.232 1.00 0.00 H ATOM 16370 P GUA 2 2.747-5. 611-23.253 1.00 0.00 P ATOM 16371 01P GUA 2 1.407-5. 221-23.746 1.00 0.00 0 ATOM 16372 02P GUA 2 3.269-5. 029-21.996 1.00 0.00 0 ATOM 16373 05'GUA 2 2.789-7. 216-23.121 1.00 0.00 O ATOM 16374 C5'GUA 2 2.263-8. 044-24.162 1.00 0.00 C ATOM 16375 C4'GUA 2 2.559-9. 521-23.915 1.00 0.00 C ATOM 16376 04'GUA 2 3.964-9. 776-23.822 1.00 0.00 0 ATOM 16377 C1'GUA 2 4.198-10. 803-22.836 1.00 0.00 C ATOM 16378 N9 GUA 2 5.039-10. 300-21.729 1.00 0.00 N ATOM 16379 C4 GUA 2 5.751-11. 063-20.827 1.00 0.00 C ATOM 16380 N3 GUA 2 5.785-12. 415-20.782 1.00 0.00 N ATOM 16381 C2 GUA 2 6.565-12. 869-19.796 1.00 0.00 C ATOM 16382 N2 GUA 2 6.706-14. 180-19.607 1.00 0.00 N ATOM 16383 N1 GUA 2 7.255-12. 048-18.927 1.00 0.00 N ATOM 16384 C6 GUA 2 7. 236-10. 660-18.952 1.00 0.00 C ATOM 16385 06 GUA 2 7.891-10. 020-18. 134 1.00 0.00 0 ATOM 16386 C5 GUA 2 6.408-10. 169-19.996 1.00 0.00 C ATOM 16387 N7 GUA 2 6.118-8. 851-20. 362 1.00 0.00 N ATOM 16388 C8 GUA 2 5.325-9. 024-21.365 1.00 0.00 C ATOM 16389 C2'GUA 2 2.820-11. 232-22.332 1.00 0.00 C ATOM 16390 02'GUA 2 2.316-12. 353-23.070 1.00 0.00 0 ATOM 16391 C3'GUA 2 2.000-9. 983-22.585 1.00 0.00 C ATOM 16392 03'GUA 2 0.630-10. 353-22.769 1.00 0.00 0 ATOM 16393 1H5'GUA 2 2.707-7. 747-25.112 1.00 0.00 H ATOM 16394 2H5'GUA 2 1.183-7. 903-24.216 1.00 0.00 H ATOM 16395 H4'GUA 2 2.136-10. 121-24.719 1.00 0.00 H ATOM 16396 H1'GUA 2 4.690-11. 652-23.310 1.00 0.00 H

ATOM 16397 1H2 GUA 2 6.222-14. 832-20. 208 1.00 0. 00 H ATOM 16398 2H2 GUA 2 7.297-14. 523-18.862 1.00 0.00 H ATOM 16399 H1 GUA 2 7.830-12. 469-18.210 1.00 0.00 H ATOM 16400 H8 GUA 2 4.900-8. 175-21. 900 1.00 0.00 H ATOM 16401 H2'GUA 2 2.861-11. 452-21.263 1.00 0.00 H ATOM 16402 H02'GUA 2 2.294-12. 098-23.996 1.00 0.00 H ATOM 16403 H3'GUA 2 2.135-9. 240-21.798 1.00 0.00 H ATOM 16404 P CYT 3-0. 377-10. 406-21.515 1.00 0.00 P ATOM 16405 01P CYT 3-1.752-10. 588-22.033 1.00 0.00 0 ATOM 16406 02P CYT 3-0.069-9. 267-20.622 1.00 0.00 0 ATOM 16407 05'CYT 3 0.067-11. 762-20.771 1.00 0.00 0 ATOM 16408 C5'CYT 3-0.398-13. 034-21.231 1.00 0.00 C ATOM 16409 C4'CYT 3 0. 072-14. 163-20.320 1.00 0.00 C ATOM 16410 04'CYT 3 1.500-14. 304-20.341 1.00 0.00 0 ATOM 16411 Cl'CYT 3 1.986-14. 465-18.994 1.00 0.00 C ATOM 16412 N1 CYT 3 2.712-13. 258-18.538 1.00 0.00 N ATOM 16413 C6 CYT 3 2. 319-12. 012-18. 933 1.00 0.00 C ATOM 16414 C2 CYT 3 3.803-13. 440-17.700 1.00 0.00 C ATOM 16415 02 CYT 3 4.134-14. 571-17.352 1.00 0.00 0 ATOM 16416 N3 CYT 3 4.482-12. 338-17.277 1.00 0.00 N ATOM 16417 C4 CYT 3 4.106-11. 110-17.658 1.00 0.00 C ATOM 16418 N4 CYT 3 4.797-10. 052-17.232 1.00 0.00 N ATOM 16419 C5 CYT 3 2.981-10. 919-18. 519 1.00 0.00 C ATOM 16420 C2'CYT 3 0. 749-14. 719-18.141 1.00 0.00 C ATOM 16421 02'CYT 3 0. 386-16. 105-18.138 1.00 0.00 0 ATOM 16422 C3'CYT 3-0.273-13. 873-18.869 1.00 0.00 C ATOM 16423 03'CYT 3-1.582-14. 382-18.596 1.00 0.00 0 ATOM 16424 1H5'CYT 3-0.023-13. 210-22.240 1.00 0.00 H ATOM 16425 2H5'CYT 3-1.488-13. 026-21.253 1.00 0.00 H ATOM 16426 H4'CYT 3-0.388-15. 101-20.627 1.00 0.00 H ATOM 16427 Hl'CYT 3 2.647-15. 332-18.947 1.00 0.00 H ATOM 16428 H6 CYT 3 1.461-11. 900-19.596 1.00 0.00 H ATOM 16429 1H4 CYT 3 4.525-9. 123-17.518 1.00 0.00 H ATOM 16430 2H4 CYT 3 5.592-10. 180-16.621 1.00 0.00 H ATOM 16431 H5 CYT 3 2.665-9. 923-18.824 1.00 0.00 H ATOM 16432 H2'CYT 3 0.904-14. 348-17.126 1.00 0.00 H ATOM 16433 H02'CYT 3-0.505-16. 165-17.788 1.00 0.00 H ATOM 16434 H3'CYT 3-0. 172-12. 812-18.626 1.00 0.00 H ATOM 16435 P GUA 4-2. 549-13. 626-17.555 1.00 0.00 P ATOM 16436 01P GUA 4-3. 879-14. 274-17.603 1.00 0.00 0 ATOM 16437 02P GUA 4-2.430-12. 168-17.785 1.00 0.00 0 ATOM 16438 05'GUA 4-1.868-13. 970-16.138 1.00 0.00 0 ATOM 16439 C5'GUA 4-1.974-15. 284-15.583 1.00 0.00 C ATOM 16440 C4'GUA 4-0.973-15. 503-14.452 1.00 0.00 C ATOM 16441 04'GUA 4 0.378-15. 342-14.893 1.00 0.00 0 ATOM 16442 C1'GUA 4 1.160-14. 781-13.819 1.00 0.00 C ATOM 16443 N9 GUA 4 1.775-13. 497-14.208 1.00 0.00 N ATOM 16444 C4 GUA 4 2.853-12. 892-13.602 1.00 0.00 C ATOM 16445 N3 GUA 4 3.547-13. 384-12.552 1.00 0.00 N ATOM 16446 C2 GUA 4 4.539-12. 573-12.177 1.00 0.00 C ATOM 16447 N2 GUA 4 5.320-12. 908-11. 152 1.00 0.00 N ATOM 16448 N1 GUA 4 4.820-11. 371-12.796 1.00 0.00 N ATOM 16449 C6 GUA 4 4.123-10. 845-13.877 1.00 0.00 C ATOM 16450 06 GUA 4 4.455-9. 765-14.359 1.00 0.00 0 ATOM 16451 C5 GUA 4 3.064-11. 703-14. 280 1.00 0.00 C ATOM 16452 N7 GUA 4 2.130-11. 551-15.310 1.00 0.00 N ATOM 16453 C8 GUA 4 1.431-12. 630-15.192 1.00 0.00 C ATOM 16454 C2'GUA 4 0.200-14. 586-12.645 1.00 0.00 C ATOM 16455 02'GUA 4 0.223-15. 710-11.757 1.00 0.00 O

ATOM 16456 C3'GUA 4-1.130-14. 464-13.361 1.00 0.00 C ATOM 16457 03'GUA 4-2.175-14. 875-12.474 1.00 0.00 0 ATOM 16458 1H5'GUA 4-1.789-16. 019-16.367 1.00 0.00 H ATOM 16459 2H5'GUA 4-2.983-15. 425-15.195 1.00 0.00 H ATOM 16460 H4'GUA 4-1.100-16. 500-14.033 1.00 0.00 H ATOM 16461 H1'GUA 4 1.941-15. 486-13.533 1.00 0.00 H ATOM 16462 1H2 GUA 4 5.162-13. 775-10.659 1.00 0.00 H ATOM 16463 2H2 GUA 4 6.066-12. 292-10.863 1.00 0.00 H ATOM 16464 H1 GUA 4 5.584-10. 810-12.449 1.00 0.00 H ATOM 16465 H8 GUA 4 0.590-12. 833-15.855 1.00 0.00 H ATOM 16466 H2'GUA 4 0.433-13. 659-12.115 1.00 0.00 H ATOM 16467 H02'GUA 4 1.041-15. 661-11.257 1.00 0.00 H ATOM 16468 H3'GUA 4-1.288-13. 463-13.765 1.00 0.00 H ATOM 16469 P CYT 5-2.749-13. 856-11.368 1.00 0.00 P ATOM 16470 O1P CYT 5-3.915-14. 491-10.713 1.00 0.00 0 ATOM 16471 02P CYT 5-2.892-12. 522-11.994 1.00 0.00 0 ATOM 16472 05'CYT 5-1.546-13. 784-10.300 1.00 0.00 0 ATOM 16473 C5'CYT 5-1.294-14. 880-9.417 1.00 0.00 C ATOM 16474 C4'CYT 5-0.156-14. 573-8.448 1.00 0.00 C ATOM 16475 04'CYT 5 1.083-14. 352-9.130 1.00 0.00 0 ATOM 16476 Cl'CYT 5 1.810-13. 295-8.472 1.00 0.00 C ATOM 16477 N1 CYT 5 2.000-12. 134-9.372 1.00 0.00 N ATOM 16478 C6 CYT 5 1.038-11. 777-10.274 1.00 0.00 C ATOM 16479 C2 CYT 5 3.194-11. 430-9.272 1.00 0.00 C ATOM 16480 02 CYT 5 4.047-11. 768-8.453 1.00 0.00 0 ATOM 16481 N3 CYT 5 3.388-10. 367-10.101 1.00 0.00 N ATOM 16482 C4 CYT 5 2.454-10. 007-10.990 1.00 0.00 C ATOM 16483 N4 CYT 5 2.682-8. 965-11.789 1.00 0.00 N ATOM 16484 C5 CYT 5 1.223-10. 727-11.096 1.00 0.00 C ATOM 16485 C2'CYT 5 0.987-12. 916-7.241 1.00 0.00 C ATOM 16486 02'CYT 5 1.387-13. 671-6.090 1.00 0.00 0 ATOM 16487 C3'CYT 5-0.412-13. 284-7.691 1.00 0.00 C ATOM 16488 03'CYT 5-1.212-13. 580-6.543 1.00 0.00 0 ATOM 16489 1H5'CYT 5-1.032-15. 760-10.005 1.00 0.00 H ATOM 16490 2H5'CYT 5-2.198-15. 091-8.846 1.00 0.00 H ATOM 16491 H4'CYT 5-0.039-15. 395-7.744 1.00 0.00 H ATOM 16492 H1'CYT 5 2.782-13. 669-8.152 1.00 0.00 H ATOM 16493 H6 CYT 5 0.111-12. 347-10.329 1.00 0.00 H ATOM 16494 1H4 CYT 5 3.550-8. 455-11.717 1.00 0.00 H ATOM 16495 2H4 CYT 5 1.987-8. 687-12.467 1.00 0.00 H ATOM 16496 H5 CYT 5 0.459-10. 435-11.817 1.00 0.00 H ATOM 16497 H2'CYT 5 1.059-11. 842-7.052 1.00 0.00 H ATOM 16498 H02'CYT 5 0.713-13. 545-5.418 1.00 0.00 H ATOM 16499 H3'CYT 5-0.853-12. 514-8.327 1.00 0.00 H ATOM 16500 P URI 6-2.374-12. 569-6.076 1.00 0.00 P ATOM 16501 O1P URI 6-3.258-13. 285-5.128 1.00 0.00 0 ATOM 16502 02P URI 6-2.948-11. 930-7.281 1.00 0.00 O ATOM 16503 05'URI 6-1.552-11. 454-5.258 1.00 0.00 0 ATOM 16504 C5'URI 6-0.996-11. 760-3.977 1.00 0.00 C ATOM 16505 C4'URI 6 0.003-10. 699-3.527 1.00 0.00 C ATOM 16506 04'URI 6 1.094-10. 572-4.447 1.00 0.00 0 ATOM 16507 C1'URI 6 1.450-9. 180-4.576 1.00 0.00 C ATOM 16508 N1 URI 6 1.204-8. 681-5.950 1.00 0.00 N ATOM 16509 C6 URI 6 0.272-9. 270-6.763 1.00 0.00 C ATOM 16510 C2 URI 6 1.956-7. 601-6.380 1.00 0.00 C ATOM 16511 02 URI 6 2.791-7. 055-5.661 1.00 0.00 0 ATOM 16512 N3 URI 6 1.711-7. 163-7.669 1.00 0.00 N ATOM 16513 C4 URI 6 0.793-7. 701-8. 553 1.00 0.00 C ATOM 16514 04 URI 6 0.665-7. 234-9. 683 1.00 0.00 0

ATOM 16515 C5 URI 6 0.050-8. 821-8.023 1. 00 0.00 C ATOM 16516 C2'URI 6 0.595-8. 433-3.556 1.00 0.00 C ATOM 16517 02'URI 6 1.252-8. 345-2.286 1.00 0.00 0 ATOM 16518 C3'URI 6-0.631-9. 320-3.491 1.00 0.00 C ATOM 16519 03'URI 6-1.272-9. 140-2.223 1.00 0. 00 0 ATOM 16520 1H5'URI 6-0.489-12. 724-4.029 1.00 0.00 H ATOM 16521 2H5'URI 6-1.802-11. 822-3.245 1.00 0.00 H ATOM 16522 H4'URI 6 0.390-10. 951-2.542 1.00 0.00 H ATOM 16523 H1'URI 6 2.502-9. 051-4.326 1.00 0.00 H ATOM 16524 H6 URI 6-0.302-10. 118-6.390 1.00 0.00 H ATOM 16525 H3 URI 6 2.254-6. 376-7.994 1.00 0.00 H ATOM 16526 H5 URI 6-0. 702-9.308-8. 644 1.00 0.00 H ATOM 16527 H2'URI 6 0.334-7. 444-3.934 1.00 0.00 H ATOM 16528 H02'URI 6 1.459-9. 240-2.009 1.00 0.00 H ATOM 16529 H3'URI 6-1.303-9. 152-4.334 1.00 0.00 H ATOM 16530 P CYT 7-2.480-8. 085-2.056 1.00 0.00 P ATOM 16531 01P CYT 7-3.332-8. 159-3.264 1.00 0.00 0 ATOM 16532 02P CYT 7-3.080-8. 278-0.717 1.00 0.00 O ATOM 16533 05'CYT 7-1.714-6. 669-2.067 1.00 0.00 0 ATOM 16534 C5'CYT 7-0.713-6. 378-1.089 1.00 0.00 C ATOM 16535 C4'CYT 7 0.212-5. 254-1.546 1.00 0.00 C ATOM 16536 04'CYT 7 0.758-5. 516-2.844 1.00 0.00 0 ATOM 16537 C1'CYT 7 0.837-4. 282-3.587 1.00 0.00 C ATOM 16538 N1 CYT 7-0.030-4. 303-4.787 1.00 0. 00 N ATOM 16539 C6 CYT 7-0.899-5. 332-5.020 1.00 0.00 C ATOM 16540 C2 CYT 7 0.070-3. 231-5.663 1.00 0.00 C ATOM 16541 02 CYT 7 0.858-2. 316-5.432 1.00 0.00 0 ATOM 16542 N3 CYT 7-0.720-3. 222-6.768 1.00 0.00 N ATOM 16543 C4 CYT 7-1.575-4. 222-7.010 1.00 0.00 C ATOM 16544 N4 CYT 7-2.337-4. 176-8.102 1.00 0.00 N ATOM 16545 C5 CYT 7-1.684-5. 332-6.114 1.00 0.00 C ATOM 16546 C2'CYT 7 0.400-3. 183-2.623 1.00 0.00 C ATOM 16547 02'CYT 7 1.516-2. 638-1.909 1.00 0.00 0 ATOM 16548 C3'CYT 7-0.535-3. 943-1.705 1.00 0.00 C ATOM 16549 03'CYT 7-0.579-3. 276-0.439 1.00 0. 00 0 ATOM 16550 1H5'CYT 7-0. 119-7. 275-0.911 1.00 0.00 H ATOM 16551 2H5'CYT 7-1.198-6. 084-0.158 1.00 0.00 H ATOM 16552 H4'CYT 7 1.024-5. 131-0.832 1.00 0.00 H ATOM 16553 H1'CYT 7 1.871-4. 108-3.888 1.00 0.00 H ATOM 16554 H6 CYT 7-0.962-6. 157-4.313 1.00 0.00 H ATOM 16555 1H4 CYT 7-2.989-4. 923-8.296 1. 00 0. 00 H ATOM 16556 2H4 CYT 7-2.265-3. 390-8.734 1.00 0.00 H ATOM 16557 H5 CYT 7-2.376-6. 150-6.311 1.00 0.00 H ATOM 16558 H2'CYT 7-0.144-2. 401-3.160 1.00 0.00 H ATOM 16559 H02'CYT 7 2.065-2. 176-2.546 1.00 0.00 H ATOM 16560 H3'CYT 7-1.523-4. 081-2.148 1.00 0.00 H ATOM 16561 P ADE 8-1.630-2. 082-0.177 1.00 0.00 P ATOM 16562 01P ADE 8-2.990-2. 588-0.469 1.00 0.00 O ATOM 16563 02P ADE 8-1.334-1. 486 1.145 1.00 0.00 0 ATOM 16564 05'ADE 8-1. 239-1. 009-1. 313 1.00 0.00 0 ATOM 16565 C5'ADE 8 0.012-0. 314-1.265 1.00 0.00 C ATOM 16566 C4'ADE 8 0.115 0.735-2. 370 1.00 0. 00 C ATOM 16567 04'ADE 8-0. 022 0.145-3. 674 1. 00 0. 00 O ATOM 16568 C1'ADE 8-0.952 0.918-4. 456 1.00 0.00 C ATOM 16569 N9 ADE 8-2.244 0.216-4. 602 1. 00 0.00 N ATOM 16570 C4 ADE 8-3.287 0.564-5. 435 1. 00 0.00 C ATOM 16571 N3 ADE 8-3.321 1.609-6. 289 1.00 0. 00 N ATOM 16572 C2 ADE 8-4.479 1.662-6. 944 1.00 0.00 C ATOM 16573 N1 ADE 8-5.512 0. 826-6. 824 1.00 0.00 N ATOM 16574 C6 ADE 8-5.454-0. 208-5.967 1.00 0.00 C

ATOM 16575 N6 ADE 8-6.498-1. 029-5.862 1.00 0.00 N ATOM 16576 C5 ADE 8-4.281-0. 364-5.221 1.00 0.00 C ATOM 16577 N7 ADE 8-3.888-1. 302-4.262 1.00 0.00 N ATOM 16578 C8 ADE 8-2.703-0. 888-3.963 1. 00 0.00 C ATOM 16579 C2'ADE 8-1.127 2.227-3. 702 1.00 0.00 C ATOM 16580 02'ADE 8-0.098 3.168-4. 031 1.00 0.00 0 ATOM 16581 C3'ADE 8-1.016 1.748-2. 271 1.00 0.00 C ATOM 16582 03'ADE 8-0.592 2.842-1. 450 1.00 0.00 0 ATOM 16583 1H5'ADE 8 0.823-1. 032-1.380 1.00 0.00 H ATOM 16584 2H5'ADE 8 0.107 0. 178-0. 298 1.00 0. 00 H ATOM 16585 H4'ADE 8 1.074 1.246-2. 304 1.00 0.00 H ATOM 16586 Hl'ADE 8-0.529 1.117-5. 440 1.00 0.00 H ATOM 16587 H2 ADE 8-4.599 2.479-7. 658 1.00 0.00 H ATOM 16588 1H6 ADE 8-7. 322-0. 873-6.424 1.00 0.00 H ATOM 16589 2H6 ADE 8-6.465-1. 808-5.220 1. 00 0.00 H ATOM 16590 H8 ADE 8-2.096-1. 402-3. 218 1.00 0.00 H ATOM 16591 H2'ADE 8-2.120 2.642-3. 891 1.00 0. 00 H ATOM 16592 H02'ADE 8-0.186 3.908-3. 426 1.00 0. 00 H ATOM 16593 H3'ADE 8-1.943 1.294-1. 922 1. 00 0.00 H ATOM 16594 P ADE 9-0.854 2.827 0.141 1.00 0.00 P ATOM 16595 01P ADE 9-0.710 4.211 0.645 1.00 0.00 0 ATOM 16596 02P ADE 9-0.046 1.740 0.736 1.00 0. 00 0 ATOM 16597 05'ADE 9-2. 408 2.414 0.240 1.00 0.00 0 ATOM 16598 C5'ADE 9-3.099 2.473 1.493 1.00 0.00 C ATOM 16599 C4'ADE 9-4.589 2.170 1.338 1.00 0.00 C ATOM 16600 04'ADE 9-5.197 3.023 0.362 1.00 0.00 0 ATOM 16601 C1'ADE 9-5.468 2.278-0. 837 1.00 0.00 C ATOM 16602 N9 ADE 9-4.976 3.001-2. 023 1.00 0.00 N ATOM 16603 C4 ADE 9-5.708 3.383-3. 122 1.00 0.00 C ATOM 16604 N3 ADE 9-7.023 3.173-3. 317 1.00 0.00 N ATOM 16605 C2 ADE 9-7.422 3.670-4. 481 1.00 0.00 C ATOM 16606 N1 ADE 9-6.677 4.302-5. 389 1.00 0.00 N ATOM 16607 C6 ADE 9-5.365 4.500-5. 171 1.00 0.00 C ATOM 16608 N6 ADE 9-4.636 5.134-6. 089 1.00 0.00 N ATOM 16609 C5 ADE 9-4.834 4.019-3. 971 1.00 0.00 C ATOM 16610 N7 ADE 9-3.548 4.050-3. 427 1.00 0.00 N ATOM 16611 C8 ADE 9-3.729 3.440-2. 304 1.00 0.00 C ATOM 16612 C2'ADE 9-4.752 0.941-0. 671 1.00 0.00 C ATOM 16613 02'ADE 9-5.422-0. 112-1.374 1.00 0.00 0 ATOM 16614 C3'ADE 9-4.825 0.750 0.830 1.00 0.00 C ATOM 16615 03'ADE 9-6.166 0.337 1.159 1.00 0.00 0 ATOM 16616 1H5'ADE 9-2.983 3.472 1.914 1.00 0.00 H ATOM 16617 2H5'ADE 9-2.658 1.747 2.177 1.00 0.00 H ATOM 16618 H4'ADE 9-5.086 2.311 2.295 1.00 0.00 H ATOM 16619 H1'ADE 9-6.541 2.110-0. 930 1.00 0.00 H ATOM 16620 H2 ADE 9-8.477 3.557-4. 715 1.00 0.00 H ATOM 16621 1H6 ADE 9-3.650 5.287-5. 934 1.00 0.00 H ATOM 16622 2H6 ADE 9-5.070 5.460-6. 941 1.00 0.00 H ATOM 16623 H8 ADE 9-2. 912 3.293-1. 603 1.00 0.00 H ATOM 16624 H2'ADE 9-3.709 1.028-0. 985 1.00 0.00 H ATOM 16625 H02'ADE 9-4.976-0. 933-1.151 1.00 0.00 H ATOM 16626 H3'ADE 9-4.072 0.051 1.194 1.00 0.00 H ATOM 16627 P URI 10-6.797 0. 578 2.626 1.00 0.00 P ATOM 16628 01P URI 10-5. 773 0.227 3.636 1.00 0.00 0 ATOM 16629 02P URI 10-8.129-0. 065 2.669 1. 00 0. 00 O ATOM 16630 05'URI 10-7.001 2.177 2.647 1.00 0.00 0 ATOM 16631 C5'URI 10-8. 066 2.784 3.384 1.00 0.00 C ATOM 16632 C4'URI 10-8.992 3.577 2.464 1.00 0.00 C ATOM 16633 04'URI 10-9. 707 2.713 1.566 1.00 0.00 0 ATOM 16634 C1'URI 10-11.108 2.714 1.897 1.00 0.00 C

ATOM 16635 N1 URI 10-11.672 1.345 1.866 1.00 0.00 N ATOM 16636 C6 URI 10-10.858 0.249 1.756 1.00 0.00 C ATOM 16637 C2 URI 10-13.048 1.214 1.959 1.00 0.00 C ATOM 16638 02 URI 10-13.796 2.185 2.060 1.00 0.00 0 ATOM 16639 N3 URI 10-13.538-0. 078 1.934 1.00 0.00 N ATOM 16640 C4 URI 10-12.787-1. 235 1.826 1.00 0.00 C ATOM 16641 04 URI 10-13. 332-2.336 1.814 1.00 0.00 0 ATOM 16642 C5 URI 10-11.363-1. 006 1.735 1.00 0.00 C ATOM 16643 C2'URI 10-11.195 3.312 3.294 1.00 0.00 C ATOM 16644 02'URI 10-12.459 3.946 3.524 1.00 0.00 0 ATOM 16645 C3'URI 10-10.059 4.317 3.258 1.00 0.00 C ATOM 16646 03'URI 10-10. 478 5.456 2.494 1.00 0.00 0 ATOM 16647 1H5'URI 10-7.641 3.458 4.128 1.00 0.00 H ATOM 16648 2H5'URI 10-8.641 2.010 3.893 1.00 0.00 H ATOM 16649 H4'URI 10-8.406 4.290 1.885 1.00 0.00 H ATOM 16650 H1'URI 10-11.651 3.348 1.195 1.00 0.00 H ATOM 16651 H6 URI 10-9.780 0.390 1.677 1.00 0.00 H ATOM 16652 H3 URI 10-14.540-0. 188 2.000 1.00 0.00 H ATOM 16653 H5 URI 10-10. 686-1.854 1.652 1.00 0.00 H ATOM 16654 H2'URI 10-10.992 2.544 4.046 1.00 0.00 H ATOM 16655 H02'URI 10-13. 142 3.289 3.361 1.00 0.00 H ATOM 16656 H3'URI 10-9.716 4.589 4.256 1.00 0.00 H ATOM 16657 P GUA 11-9.676 6.853 2.578 1.00 0.00 P ATOM 16658 01P GUA 11-10.436 7.867 1.813 1.00 0.00 O ATOM 16659 02P GUA 11-9.334 7.107 3.997 1.00 0.00 O ATOM 16660 05'GUA 11-8.312 6.538 1.775 1.00 0.00 0 ATOM 16661 C5'GUA 11-7.044 6.557 2.444 1.00 0.00 C ATOM 16662 C4'GUA 11-5.879 6.619 1.457 1.00 0.00 C ATOM 16663 04'GUA 11-5.901 5.512 0.539 1.00 0.00 0 ATOM 16664 C1'GUA 11-5. 782 6.006-0. 807 1.00 0.00 C ATOM 16665 N9 GUA 11-7. 095 6.037-1. 474 1.00 0.00 N ATOM 16666 C4 GUA 11-7.359 6.464-2. 752 1.00 0.00 C ATOM 16667 N3 GUA 11-6.446 6.912-3. 640 1.00 0.00 N ATOM 16668 C2 GUA 11-7.002 7.258-4. 802 1.00 0.00 C ATOM 16669 N2 GUA 11-6.239 7.711-5. 795 1.00 0.00 N ATOM 16670 N1 GUA 11-8.356 7.168-5. 060 1.00 0.00 N ATOM 16671 C6 GUA 11-9.313 6.710-4. 166 1.00 0.00 C ATOM 16672 06 GUA 11-10.496 6.671-4. 494 1.00 0.00 0 ATOM 16673 C5 GUA 11-8.728 6.339-2. 927 1.00 0.00 C ATOM 16674 N7 GUA 11-9.327 5.835-1. 769 1.00 0.00 N ATOM 16675 C8 GUA 11-8.307 5.692-0. 992 1.00 0.00 C ATOM 16676 C2'GUA 11-5.214 7.407-0. 659 1.00 0.00 C ATOM 16677 02'GUA 11-3.796 7.383-0. 453 1.00 0.00 0 ATOM 16678 C3'GUA 11-5.956 7.863 0.581 1.00 0.00 C ATOM 16679 03'GUA 11-5.213 8.915 1.204 1.00 0.00 0 ATOM 16680 1H5'GUA 11-6. 949 5.655 3.049 1.00 0.00 H ATOM 16681 2H5'GUA 11-7.001 7.428 3.098 1. 00 0.00 H ATOM 16682 H4'GUA 11-4.936 6.614 2.003 1.00 0.00 H ATOM 16683 H1'GUA 11-5.094 5.381-1. 375 1.00 0.00 H ATOM 16684 1H2 GUA 11-6.659 7.973-6. 675 1.00 0.00 H ATOM 16685 2H2 GUA 11-5.241 7.791-5. 668 1.00 0.00 H ATOM 16686 Hl GUA 11-8.698 7.457-5. 964 1.00 0.00 H ATOM 16687 H8 GUA 11-8.415 5.309 0.019 1.00 0. 00 H ATOM 16688 H2'GUA 11-5.482 8.023-1. 521 1.00 0.00 H ATOM 16689 H02'GUA 11-3.624 6.786 0.279 1.00 0.00 H ATOM 16690 H3'GUA 11-6. 986 8.147 0.359 1.00 0. 00 H ATOM 16691 P CYT 12-5.689 10.446 1.053 1.00 0.00 P ATOM 16692 01P CYT 12-7.127 10.521 1.394 1.00 0.00 0 ATOM 16693 02P CYT 12-4.716 11.305 1.764 1.00 0.00 0 ATOM 16694 05'CYT 12-5.534 10.707-0. 529 1.00 0.00 0

ATOM 16695 C5'CYT 12-4.238 10.826-1. 123 1.00 0.00 C ATOM 16696 C4'CYT 12-4.326 10.995-2. 637 1.00 0.00 C ATOM 16697 04'CYT 12-4.993 9.887-3. 255 1.00 0.00 0 ATOM 16698 C1'CYT 12-5.893 10.371-4. 270 1.00 0.00 C ATOM 16699 N1 CYT 12-7.308 10.131-3. 896 1.00 0.00 N ATOM 16700 C6 CYT 12-7.654 9.808-2. 613 1.00 0.00 C ATOM 16701 C2 CYT 12-8.265 10.221-4. 901 1.00 0.00 C ATOM 16702 02 CYT 12-7.936 10.527-6. 047 1.00 0.00 0 ATOM 16703 N3 CYT 12-9.564 9.970-4. 580 1.00 0.00 N ATOM 16704 C4 CYT 12-9.913 9.648-3. 327 1.00 0.00 C ATOM 16705 N4 CYT 12-11.190 9.388-3. 050 1.00 0.00 N ATOM 16706 C5 CYT 12-8.936 9.562-2. 289 1.00 0.00 C ATOM 16707 C2'CYT 12-5.600 11.859-4. 414 1.00 0.00 C ATOM 16708 02'CYT 12-4.568 12.097-5. 375 1.00 0.00 0 ATOM 16709 C3'CYT 12-5.156 12.212-3. 011 1.00 0.00 C ATOM 16710 03'CYT 12-4.292 13.352-3. 072 1.00 0.00 0 ATOM 16711 1H5'CYT 12-3.660 9.929-0. 899 1.00 0.00 H ATOM 16712 2H5'CYT 12-3.730 11.692-0. 698 1.00 0.00 H ATOM 16713 H4'CYT 12-3.325 11.091-3. 055 1.00 0.00 H ATOM 16714 H1'CYT 12-5.677 9.870-5. 213 1.00 0.00 H ATOM 16715 H6 CYT 12-6.883 9.743-1. 845 1.00 0.00 H ATOM 16716 1H4 CYT 12-11. 461 9.134-2. 111 1.00 0.00 H ATOM 16717 2H4 CYT 12-11.885 9.435-3. 781 1.00 0.00 H ATOM 16718 H5 CYT 12-9. 222 9.313-1. 268 1.00 0.00 H ATOM 16719 H2'CYT 12-6.511 12.398-4. 674 1.00 0.00 H ATOM 16720 H02'CYT 12-4.902 11.806-6. 227 1.00 0.00 H ATOM 16721 H3'CYT 12-6.003 12.360-2. 340 1.00 0.00 H ATOM 16722 P URI 13-4.875 14.833-2. 836 1.00 0.00 P ATOM 16723 01P URI 13-3.738 15.781-2. 816 1.00 0.00 0 ATOM 16724 02P URI 13-5.816 14.786-1. 695 1.00 0.00 0 ATOM 16725 05'URI 13-5.724 15.091-4. 179 1.00 0.00 0 ATOM 16726 C5'URI 13-5.062 15.331-5. 423 1.00 0.00 C ATOM 16727 C4'URI 13-6.039 15.286-6. 594 1.00 0.00 C ATOM 16728 04'URI 13-6.678 14.008-6. 701 1.00 0.00 O ATOM 16729 C1'URI 13-8.068 14.193-7. 035 1.00 0.00 C ATOM 16730 N1 URI 13-8.953 13.734-5. 940 1.00 0.00 N ATOM 16731 C6 URI 13-8.512 13.685-4. 642 1.00 0.00 C ATOM 16732 C2 URI 13-10.234 13.336-6. 280 1.00 0.00 C ATOM 16733 02 URI 13-10.651 13.380-7. 436 1.00 0.00 0 ATOM 16734 N3 URI 13-11.027 12.888-5. 242 1.00 0.00 N ATOM 16735 C4 URI 13-10.660 12.802-3. 911 1.00 0.00 C ATOM 16736 04 URI 13-11.444 12.368-3. 072 1.00 0.00 0 ATOM 16737 C5 URI 13-9.310 13.240-3. 643 1.00 0.00 C ATOM 16738 C2'URI 13-8.243 15.685-7. 299 1.00 0.00 C ATOM 16739 02'URI 13-8.010 16.005-8. 677 1.00 0.00 0 ATOM 16740 C3'URI 13-7.175 16.273-6. 402 1.00 0.00 C ATOM 16741 03'URI 13-6.775 17.542-6. 928 1.00 0.00 0 ATOM 16742 1H5'URI 13-4.293 14.573-5. 572 1.00 0.00 H ATOM 16743 2H5'URI 13-4.591 16.314-5. 391 1.00 0.00 H ATOM 16744 H4'URI 13-5.513 15.506-7. 522 1.00 0.00 H ATOM 16745 Hl'URI 13-8.296 13.636-7. 944 1.00 0.00 H ATOM 16746 H6 URI 13-7.499 14.012-4. 407 1.00 0.00 H ATOM 16747 H3 URI 13-11.965 12.600-5. 477 1.00 0.00 H ATOM 16748 H5 URI 13-8.929 13.213-2. 622 1.00 0.00 H ATOM 16749 H2'URI 13-9.235 16.014-6. 981 1.00 0.00 H ATOM 16750 H02'URI 13-7.810 16.942-8. 722 1.00 0.00 H ATOM 16751 H3'URI 13-7.501 16.330-5. 362 1.00 0.00 H ATOM 16752 P CYT 14-7.436 18. 901-6. 371 1.00 0.00 P ATOM 16753 O1P CYT 14-7.474 18.826-4. 893 1.00 0.00 0 ATOM 16754 02P CYT 14-6.771 20.044-7. 035 1.00 0.00 0

ATOM 16755 05'CYT 14-8.947 18.805-6. 919 1.00 0.00 0 ATOM 16756 C5'CYT 14-9.251 19.114-8. 282 1.00 0.00 C ATOM 16757 C4'CYT 14-10.715 18. 835-8. 609 1.00 0.00 C ATOM 16758 04'CYT 14-11.051 17.458-8. 403 1.00 0.00 0 ATOM 16759 Cl'CYT 14-12.377 17.366-7. 843 1.00 0.00 C ATOM 16760 N1 CYT 14-12.354 16.762-6. 493 1.00 0.00 N ATOM 16761 C6 CYT 14-11.271 16.907-5. 676 1.00 0.00 C ATOM 16762 C2 CYT 14-13.477 16.054-6. 087 1.00 0.00 C ATOM 16763 02 CYT 14-14.445 15.945-6. 837 1.00 0.00 0 ATOM 16764 N3 CYT 14-13.477 15.499-4. 845 1.00 0.00 N ATOM 16765 C4 CYT 14-12.421 15. 633-4.033 1.00 0.00 C ATOM 16766 N4 CYT 14-12.454 15.078-2. 822 1.00 0.00 N ATOM 16767 C5 CYT 14-11.262 16.362-4. 447 1.00 0.00 C ATOM 16768 C2'CYT 14-12. 918 18.791-7. 788 1.00 0.00 C ATOM 16769 02'CYT 14-13.657 19.118-8. 971 1.00 0.00 0 ATOM 16770 C3'CYT 14-11.641 19.599-7. 682 1.00 0.00 C ATOM 16771 03'CYT 14-11. 873 20.900-8. 230 1.00 0.00 0 ATOM 16772 lH5'CYT 14-8.620 18.510-8. 935 1.00 0.00 H ATOM 16773 2H5'CYT 14-9.042 20.168-8. 462 1.00 0.00 H ATOM 16774 H4'CYT 14-10.922 19.107-9. 642 1.00 0.00 H ATOM 16775 Hl'CYT 14-13.006 16.764-8. 500 1.00 0.00 H ATOM 16776 H6 CYT 14-10. 405 17. 471-6.022 1.00 0.00 H ATOM 16777 1H4 CYT 14-11.664 15.172-2. 201 1.00 0.00 H ATOM 16778 2H4 CYT 14-13.273 14.565-2. 524 1.00 0.00 H ATOM 16779 H5 CYT 14-10.404 16.476-3. 788 1.00 0.00 H ATOM 16780 H2'CYT 14-13.529 18.926-6. 891 1.00 0.00 H ATOM 16781 H02'CYT 14-14.469 18.607-8. 950 1.00 0.00 H ATOM 16782 H3'CYT 14-11.263 19.634-6. 659 1.00 0.00 H ATOM 16783 P URI 15-12.380 22. 103-7.287 1.00 0.00 P ATOM 16784 01P URI 15-12.682 23.270-8. 145 1.00 0.00 O ATOM 16785 02P URI 15-11.429 22.241-6. 161 1.00 0.00 O ATOM 16786 05'URI 15-13.768 21. 530-6.704 1.00 0.00 O ATOM 16787 C5'URI 15-14. 934 21.457-7. 531 1.00 0.00 C ATOM 16788 C4'URI 15-16.071 20.712-6. 835 1.00 0.00 C ATOM 16789 04'URI 15-15.714 19. 355-6.533 1.00 0.00 0 ATOM 16790 C1'URI 15-16.166 19.024-5. 204 1.00 0.00 C ATOM 16791 N1 URI 15-15. 026 18.868-4. 273 1.00 0.00 N ATOM 16792 C6 URI 15-13.901 19.636-4. 403 1.00 0.00 C ATOM 16793 C2 URI 15-15.144 17.927-3. 264 1.00 0. 00 C ATOM 16794 02 URI 15-16.148 17.233-3. 127 1.00 0.00 O ATOM 16795 N3 URI 15-14.063 17.815-2. 409 1.00 0.00 N ATOM 16796 C4 URI 15-12.893 18.551-2. 471 1.00 0.00 C ATOM 16797 04 URI 15-11.993 18.365-1. 656 1.00 0.00 O ATOM 16798 C5 URI 15-12.858 19.509-3. 553 1.00 0.00 C ATOM 16799 C2'URI 15-17. 064 20.178-4. 776 1.00 0.00 C ATOM 16800 02'URI 15-18.415 19.988-5. 213 1.00 0.00 0 ATOM 16801 C3'URI 15-16.399 21.337-5. 490 1.00 0.00 C ATOM 16802 03'URI 15-17.362 22.376-5. 687 1.00 0.00 O ATOM 16803 1H5'URI 15-14. 683 20.939-8. 457 1. 00 0.00 H