Title:
MODIFIED ACTIVIN A
Document Type and Number:
WIPO Patent Application WO/2020/100993
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide modified activin A. The present invention provides activin A that includes a modified proregion.
Inventors:
TAKAYAMA HIDEHITO (JP)
WATANABE RISA (JP)
TAKEMOTO YUTAKA (JP)
TANAKA HIROYUKI (JP)
KAWABATA HIROSHI (JP)
YOSHINAKA KYOJI (JP)
WATANABE RISA (JP)
TAKEMOTO YUTAKA (JP)
TANAKA HIROYUKI (JP)
KAWABATA HIROSHI (JP)
YOSHINAKA KYOJI (JP)
Application Number:
PCT/JP2019/044744
Publication Date:
May 22, 2020
Filing Date:
November 14, 2019
Export Citation:
Assignee:
MITSUBISHI CHEM CORP (JP)
UNIBIO CORP (JP)
UNIBIO CORP (JP)
International Classes:
C07K14/52; A01H5/00; C12N15/19; C12N15/63; C12P21/02
Domestic Patent References:
| WO2002099067A2 | 2002-12-12 |
Foreign References:
| JP2005501558A | 2005-01-20 | |||
| JP2018214630A | 2018-11-15 |
Other References:
WANG X. ET AL.: "Structure and activation of pro-activin A", NAT. COMMUN., vol. 7, no. 12052, 4 July 2016 (2016-07-04), XP055642542
FISCHER W.H. ET AL.: "Residues in the C-terminal region of activin A determine specificity for follistatin and type II receptor binding", J. ENDOCRINOL., vol. 176, no. 1, January 2003 (2003-01-01), pages 61 - 68, XP002372264, DOI: 10.1677/joe.0.1760061
SAINSBURY ET AL., CURR. OPIN. PLANT BIOL., vol. 19, no. 1-7, 2014
MANDAL MK ET AL., FRONT PLANT SCI., vol. 7, 2015, pages 267
PILLARY P. ET AL., BIOENGINEERED, vol. 5, no. 1, 2014, pages 15 - 20
WANG X. ET AL., NAT. COMMUN., vol. 7, 4 July 2016 (2016-07-04), pages 12052
KORETZ K. ET AL., HISTOCHEMISTRY, vol. 86, no. 5, 1987, pages 471 - 8
"GenBank", Database accession no. NP 002183.1
"Molecular Cloning, A Laboratory Manual (4th edition", 2012, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3882262A4
FISCHER W.H. ET AL.: "Residues in the C-terminal region of activin A determine specificity for follistatin and type II receptor binding", J. ENDOCRINOL., vol. 176, no. 1, January 2003 (2003-01-01), pages 61 - 68, XP002372264, DOI: 10.1677/joe.0.1760061
SAINSBURY ET AL., CURR. OPIN. PLANT BIOL., vol. 19, no. 1-7, 2014
MANDAL MK ET AL., FRONT PLANT SCI., vol. 7, 2015, pages 267
PILLARY P. ET AL., BIOENGINEERED, vol. 5, no. 1, 2014, pages 15 - 20
WANG X. ET AL., NAT. COMMUN., vol. 7, 4 July 2016 (2016-07-04), pages 12052
KORETZ K. ET AL., HISTOCHEMISTRY, vol. 86, no. 5, 1987, pages 471 - 8
"GenBank", Database accession no. NP 002183.1
"Molecular Cloning, A Laboratory Manual (4th edition", 2012, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3882262A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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