Title:
MODIFIED BACE
Document Type and Number:
WIPO Patent Application WO2003072733
Kind Code:
A3
Abstract:
The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.
Inventors:
CHOU KUO-CHEN (US)
HOWE JEFFREY W (US)
HOWE JEFFREY W (US)
Application Number:
PCT/US2003/005508
Publication Date:
August 11, 2005
Filing Date:
February 21, 2003
Export Citation:
Assignee:
UPJOHN CO (US)
CHOU KUO-CHEN (US)
HOWE JEFFREY W (US)
CHOU KUO-CHEN (US)
HOWE JEFFREY W (US)
International Classes:
C12N1/21; C12N9/50; C12N9/64; C12N15/09; (IPC1-7): C12N1/21; C12N15/52; C12N9/64; C07H21/04
Domestic Patent References:
| WO2001050829A2 | 2001-07-19 |
Other References:
VASSAR ET AL.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE", SCIENCE, vol. 286, 22 October 1999 (1999-10-22), pages 735 - 741, XP000914811
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