Title:
MODIFIED CASPASE POLYPEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/164348
Kind Code:
A3
Abstract:
The technology relates in part to compositions comprising modified caspase-9 polypeptides, compositions comprising nucleic acids coding for modified caspase-9 polypeptides, chimeric modified caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified caspase-9 protein, with reduced basal activity in the absence of the inducer.
Inventors:
SPENCER DAVID (US)
CHANG WEI-CHUN (US)
CHANG WEI-CHUN (US)
Application Number:
PCT/US2014/022004
Publication Date:
March 05, 2015
Filing Date:
March 07, 2014
Export Citation:
Assignee:
BELLICUM PHARMACEUTICALS INC (US)
International Classes:
A01N65/00; C12N5/00; C12P21/00
Foreign References:
| US20110286980A1 | 2011-11-24 | |||
| US6403765B1 | 2002-06-11 |
Other References:
BRADY ET AL.: "Regulation of Caspase 9 through Phosphorylation by Protein Kinase C Zeta in Response to Hyperosmotic Stress", MOLECULAR AND CELLULAR BIOLOGY, vol. 25, no. 23, 1 December 2005 (2005-12-01), pages 10543 - 10555, XP055293374, DOI: 10.1128/MCB.25.23.10543-10555.2005
DENAULT ET AL.: "Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9", BIOCHEM. J., vol. 405, no. 1, 1 July 2007 (2007-07-01), pages 11 - 19, XP055293379, DOI: 10.1042/BJ20070288
CHAO ET AL.: "Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation", PLOS BIOL, vol. 3, no. 6, 1 June 2005 (2005-06-01), pages 1 - 9, XP055250949, DOI: 10.1371/JOURNAL.PBIO.0030183
DENAULT ET AL.: "Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9", BIOCHEM. J., vol. 405, no. 1, 1 July 2007 (2007-07-01), pages 11 - 19, XP055293379, DOI: 10.1042/BJ20070288
CHAO ET AL.: "Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation", PLOS BIOL, vol. 3, no. 6, 1 June 2005 (2005-06-01), pages 1 - 9, XP055250949, DOI: 10.1371/JOURNAL.PBIO.0030183
Attorney, Agent or Firm:
SILVERSTEIN, Sheryl, R. et al. (c/o PortfolioIPP.O. Box 5205, Minneapolis MN, US)
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