Title:
MODIFIED CEA NUCLEIC ACID AND EXPRESSION VECTORS
Document Type and Number:
WIPO Patent Application WO2003085087
Kind Code:
A3
Abstract:
The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and / or treating cancer. The invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer. One such foreign DNA sequence is modified CEA nucleic acid.
Inventors:
PARRINGTON MARK (CA)
ZHANG LINONG (CA)
ROVINSKI BENI (CA)
GRITZ LINDA R (US)
GREENHALGH TRISH
ZHANG LINONG (CA)
ROVINSKI BENI (CA)
GRITZ LINDA R (US)
GREENHALGH TRISH
Application Number:
PCT/US2003/010916
Publication Date:
November 27, 2003
Filing Date:
April 09, 2003
Export Citation:
Assignee:
AVENTIS PASTEUR (CA)
THERION BIOLOGICS INC (US)
PARRINGTON MARK (CA)
ZHANG LINONG (CA)
ROVINSKI BENI (CA)
GRITZ LINDA R (US)
GREENHALGH TRISH
THERION BIOLOGICS INC (US)
PARRINGTON MARK (CA)
ZHANG LINONG (CA)
ROVINSKI BENI (CA)
GRITZ LINDA R (US)
GREENHALGH TRISH
International Classes:
A61F2/28; A61F2/44; A61F2/46; A61K39/00; A61K39/275; A61P35/00; C07K14/47; C12N15/12; C12N15/86; A61B17/28; A61F2/00; A61F2/30; (IPC1-7): A61K39/275
Foreign References:
| US5942235A | 1999-08-24 | |||
| US5833975A | 1998-11-10 | |||
| US5698530A | 1997-12-16 |
Other References:
HODGE ET AL.: "A triad of costimulatory molecules synergize to amplify T-cell activation", CANCER RESEARCH, vol. 59, no. 22, 15 November 1999 (1999-11-15), pages 5800 - 5807, XP000882899
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