Title:
MODIFIED CELL, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016514
Kind Code:
A1
Abstract:
A modified cell, a method for preparing a modified cell, and a use thereof in treatment of a disease. The modified cell comprises a polynucleotide that codes a presenting peptide, wherein the polynucleotide is under the transcriptional regulation of an endogenous B2M gene.
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Inventors:
HUANG ZHUO (CN)
LIN YANNI (CN)
ZHENG XIAOCUI (CN)
LIN YANNI (CN)
ZHENG XIAOCUI (CN)
Application Number:
PCT/CN2022/111713
Publication Date:
February 16, 2023
Filing Date:
August 11, 2022
Export Citation:
Assignee:
CURE GENETICS CO LTD (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; C07K14/74; C12N5/0783; C12N15/62
Domestic Patent References:
| WO2021027758A1 | 2021-02-18 | |||
| WO2021027200A1 | 2021-02-18 | |||
| WO2019238015A1 | 2019-12-19 | |||
| WO2021027758A1 | 2021-02-18 |
Foreign References:
| US20210070835A1 | 2021-03-11 | |||
| CN112040769A | 2020-12-04 |
Other References:
CREW, M.D. ; CANNON, M.J. ; PHANAVANH, B. ; GARCIA-BORGES, C.N.: "An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cells", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 42, no. 10, 1 June 2005 (2005-06-01), GB , pages 1205 - 1214, XP027634988, ISSN: 0161-5890
TAFURO S, ET AL.: "RECONSTITUTION OF ANTIGEN PRESENTATION IN HLA CLASS I-NEGATIVE CANCER CELLS WITH PEPTIDE-BETA2M FUSION MOLECULES", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-VCH, HOBOKEN, USA, vol. 31, no. 02, 1 February 2001 (2001-02-01), Hoboken, USA, pages 440 - 449, XP001020497, ISSN: 0014-2980, DOI: 10.1002/1521-4141(200102)31:2<440::AID-IMMU440>3.0.CO;2-0
"UniProt", Database accession no. J7RUA5
"Uniprot", Database accession no. A0A191URJ7
"NCBI", Database accession no. NP_001358692.1
SCHUMANN ET AL., PNAS, vol. 112, 2015, pages 10437 - 10442
TAFURO S, ET AL.: "RECONSTITUTION OF ANTIGEN PRESENTATION IN HLA CLASS I-NEGATIVE CANCER CELLS WITH PEPTIDE-BETA2M FUSION MOLECULES", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-VCH, HOBOKEN, USA, vol. 31, no. 02, 1 February 2001 (2001-02-01), Hoboken, USA, pages 440 - 449, XP001020497, ISSN: 0014-2980, DOI: 10.1002/1521-4141(200102)31:2<440::AID-IMMU440>3.0.CO;2-0
"UniProt", Database accession no. J7RUA5
"Uniprot", Database accession no. A0A191URJ7
"NCBI", Database accession no. NP_001358692.1
SCHUMANN ET AL., PNAS, vol. 112, 2015, pages 10437 - 10442
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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