MODIFIED CELLS EVOKING REDUCED IMMUNOGENIC RESPONSES

Title:

MODIFIED CELLS EVOKING REDUCED IMMUNOGENIC RESPONSES

Document Type and Number:

WIPO Patent Application WO/2016/112779

Kind Code:

A1

Abstract:

Provided are composition, methods and systems associated with a genetically modified stem cell. The modified stem cell includes a reduced amount of Major Histcompatibility Complex II (MHC II) as compared to a corresponding wild-type cell. Further, the modified cell has decreased immunogenicity as compared to the corresponding wild-type cell.

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Inventors:

XIAO LEI (CN)
CHEN HAIDE (CN)
CUI CHUN (CN)
LI YANG (CN)
CUI DI (CN)

Application Number:

PCT/CN2015/099322

Publication Date:

July 21, 2016

Filing Date:

December 29, 2015

Export Citation:

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Assignee:

UNIV ZHEJIANG (CN)

International Classes:

C12N5/0735; A61K48/00; C07K14/74; C12N5/074; C12N5/0775; C12N5/0789; C12N5/0797; C12N5/095

Domestic Patent References:

WO2013158292A1

2013-10-24

Foreign References:

CN103442724A	2013-12-11
CN101595212A	2009-12-02
CN101126080A	2008-02-20

Other References: