Title:
MODIFIED CREATINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2013/043580
Kind Code:
A3
Abstract:
The invention discloses creatine derivatives that are represented by Formula (I), Formula (II), and Formula (III); wherein Z is a functional group; Y is a mitochondrial targeting agent, a cationic ammonium group, or a polypeptide containing at least one positively charged amino acid residue; each R1 is independently hydrogen, alkyl, or a phosphate group; R2 a linker; R3 is a spacer group; R4 is hydrogen, alkyl, aryl, or heterocyclic; or R4 and R1, or R4 and R3, together with the nitrogen atoms to which they are attached form a heterocyclic ring, and W is hydrogen or alkyl.
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Inventors:
KHAN SHAHARYAR M (US)
GADWOOD ROBERT C (US)
ROMERO ARTHUR GLENN (US)
GADWOOD ROBERT C (US)
ROMERO ARTHUR GLENN (US)
Application Number:
PCT/US2012/055887
Publication Date:
June 27, 2013
Filing Date:
September 18, 2012
Export Citation:
Assignee:
GENCIA CORP (US)
International Classes:
C07F9/54; A61K31/66; A61P21/00
Domestic Patent References:
| WO2009033130A1 | 2009-03-12 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TSE, BRIAN N. ET AL: "Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable for in Vitro Selection", XP002693487, retrieved from STN Database accession no. 2008:1313001
Attorney, Agent or Firm:
O'BRIEN, Jonathan P. et al. (350 East Michigan Avenue Suite 30, Kalamazoo MI, US)
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