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Title:
MODIFIED FACTOR IX
Document Type and Number:
WIPO Patent Application WO2003020764
Kind Code:
A3
Abstract:
The invention in particular relates to the modification of human factor IX to result in factor IX proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates, furthermore, to T-cell epitope sequences deriving from human factor IX, which are immunogenic.

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Inventors:
CARR FRANCIS J (GB)
CARTER GRAHAM (GB)
Application Number:
PCT/EP2002/009717
Publication Date:
November 20, 2003
Filing Date:
August 30, 2002
Export Citation:
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Assignee:
MERCK PATENT GMBH (DE)
CARR FRANCIS J (GB)
CARTER GRAHAM (GB)
International Classes:
A61K38/00; A61P7/04; A61P43/00; C07K7/06; C12N15/09; C07K7/08; C07K14/745; C12N9/64; C12N15/57; C12P21/02; (IPC1-7): C12N9/64; C07K14/745; C12N15/57; A61K38/48
Domestic Patent References:
WO2000034317A22000-06-15
WO1994029370A11994-12-22
WO1998052976A11998-11-26
WO1999046274A11999-09-16
Other References:
BOTTEMA C D K ET AL: "MISSENSE MUTATION AND EVOLUTIONARY CONSERVATION OF AMINO ACIDS EVIDENCE THAT MANY OF THE AMINO ACIDS IN FACTOR IX FUNCTION AS SPACER ELEMENTS", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 49, no. 4, 1991, pages 820 - 838, XP009007557, ISSN: 0002-9297
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