Title:
MODIFIED IL-2 POLYPEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/140416
Kind Code:
A2
Abstract:
The present disclosure relates to modified IL-2 polypeptides, compositions comprising modified IL-2 polypeptides, methods of making the same, and methods of using the modified IL-2 polypeptides for treatment of diseases. In one aspect, the disclosure relates to the treatment of cancer using the modified IL-2 polypeptides. In some embodiments, the disclosed IL-2 polypeptides exhibit preferential binding characteristics to IL-2 receptor βγ complex (LL-2Κβ) over IL-2 receptor αβγ complex (LL-2Rα). In some embodiments, the molecular weight distribution of the modified IL-2 polypeptides is monodispersed.
Inventors:
PATTABIRAMAN VIJAYA (CH)
BODE JEFFREY (CH)
KURTULDU SAHIN (CH)
MAYMEG ALEXANDER (CH)
WEIBEL FRANZI (CH)
DELON CAMILLE (CH)
HAYDN ANNA (CH)
FLOHR ALEXANDER (CH)
BOEHRINGER REGIS (CH)
IACONE ROBERTO (CH)
FETZ CLAUDIA (CH)
OTTAVIANT GIORGIO (CH)
ARMENTANI ERIC (CH)
CARRALOT JEAN-PHILIPPE (CH)
AREVALO-RUIZ MATILDE (CH)
BODE JEFFREY (CH)
KURTULDU SAHIN (CH)
MAYMEG ALEXANDER (CH)
WEIBEL FRANZI (CH)
DELON CAMILLE (CH)
HAYDN ANNA (CH)
FLOHR ALEXANDER (CH)
BOEHRINGER REGIS (CH)
IACONE ROBERTO (CH)
FETZ CLAUDIA (CH)
OTTAVIANT GIORGIO (CH)
ARMENTANI ERIC (CH)
CARRALOT JEAN-PHILIPPE (CH)
AREVALO-RUIZ MATILDE (CH)
Application Number:
PCT/IB2021/000004
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
BRIGHT PEAK THERAPEUTICS AG (CH)
International Classes:
C07K14/55; A61K47/60; A61P35/00
Foreign References:
| US20160107999A1 | 2016-04-21 | |||
| US10266502B2 | 2019-04-23 | |||
| US20190204330A1 | 2019-07-04 |
Other References:
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1418
HEIN: "Click Chemistry, A Powerful Tool for Pharmaceutical Sciences", PHARMACEUTICAL RESEARCH, vol. 25, 2008, pages 2216 - 2230, XP019613182
THIRUMURUGAN ET AL.: "Click Chemistry for Drug Development and Diverse Chemical-Biology Applications", CHEM. REV., vol. 113, no. 7, 2013, pages 4905 - 4979, XP055165867, DOI: 10.1021/cr200409f
HEIN: "Click Chemistry, A Powerful Tool for Pharmaceutical Sciences", PHARMACEUTICAL RESEARCH, vol. 25, 2008, pages 2216 - 2230, XP019613182
THIRUMURUGAN ET AL.: "Click Chemistry for Drug Development and Diverse Chemical-Biology Applications", CHEM. REV., vol. 113, no. 7, 2013, pages 4905 - 4979, XP055165867, DOI: 10.1021/cr200409f
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