MODIFIED IMMUNOGENIC PNEUMOLYSIN, COMPOSITIONS AND THEIR USE AS VACCINES

Title:

MODIFIED IMMUNOGENIC PNEUMOLYSIN, COMPOSITIONS AND THEIR USE AS VACCINES

Document Type and Number:

WIPO Patent Application WO1999003884

Kind Code:

A3

Abstract:

This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also provides a method for generating novel pneumolysin variants with these desired characteristic properties. The invention also provides immunogenic compositions useful as pharmaceutical compositions including vaccines in which non-toxic, modified pneumolysin is used to stimulate protective immunity against Streptococcus pneumoniae. The vaccines may be compositions in which the modified pneumolysin in conjurated to bacterial polysaccharides or may be carried on an attenuated viral vector. In addition, the invention also provides a method of using the non-toxic, modified pneumolysin toxoid in order to stimulate antibodies against Streptococcus pneumoniae in a treated individual which are then isolated and transferred to a second individual, thereby conferring protection against Streptococcus pneumoniae in thesecond individual.

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Inventors:

MINETTI CONCEICAO (US)
MICHON FRANCIS (US)
PULLEN JEFFREY K (US)
POLVINO-BODNAR MARYELLEN (US)
LIANG SHU-MEI (US)
TAI JOSEPH Y (US)

Application Number:

PCT/US1998/014716

Publication Date:

April 08, 1999

Filing Date:

July 21, 1998

Export Citation:

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Assignee:

NORTH AMERICAN VACCINE INC (US)
MINETTI CONCEICAO (US)
MICHON FRANCIS (US)
PULLEN JEFFREY K (US)
POLVINO BODNAR MARYELLEN (US)
LIANG SHU MEI (US)
TAI JOSEPH Y (US)

International Classes:

C07K14/195; C07K14/315; C12N1/19; C12N1/21; C12N15/09; C12N5/10; (IPC1-7): C12N15/11; C07K14/315; C07K16/20; A61K39/09

Domestic Patent References:

WO1990006951A1	1990-06-28
WO1996005859A1	1996-02-29
WO1995016711A1	1995-06-22

Other References:

MICHON F. ET AL.: "Multivalent pneumococal capsular polysaccharide conjugate vaccines emloying genetically detoxified pneumolysin as a carrier protein", VACCINE, vol. 16, no. 18, November 1998 (1998-11-01), UK, pages 1732 - 1741, XP002089380

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