Title:
MODIFIED MEMBRANE PERMEABILITY
Document Type and Number:
WIPO Patent Application WO/2017/079872
Kind Code:
A1
Abstract:
Provided are microorganisms genetically modified to overexpress porin polypeptides to enhance the production of lysine and lysine derivatives by the microorganism. Also provided are methods of generating such microorganism, and methods of producing lysine and lysine derivatives using the genetically modified microorganisms.
Inventors:
CHOU HOWARD (CN)
YU LIJUN (CN)
LIU XIUCAI (CN)
YU LIJUN (CN)
LIU XIUCAI (CN)
Application Number:
PCT/CN2015/094121
Publication Date:
May 18, 2017
Filing Date:
November 09, 2015
Export Citation:
Assignee:
CATHAY R & D CENTER CO LTD (CN)
CATHAY IND BIOTECH LTD (KY)
CATHAY IND BIOTECH LTD (KY)
International Classes:
C12N1/21; C12N15/52; C12P13/04
Domestic Patent References:
| WO2003008607A2 | 2003-01-30 | |||
| WO2005073390A2 | 2005-08-11 |
Foreign References:
| CN1993461A | 2007-07-04 | |||
| US4551433A | 1985-11-05 | |||
| CN2014080873W | 2014-06-26 | |||
| CN2015072978W | 2015-02-13 |
Other References:
ZHANG LEI ET AL.: "Construction, Expression and Pur if ica tion of Gene Encod ing Omp25d Prote in of B ruce lla m e litensis in Prokaryotic Cell", SCIENCE TECHNOLOGY AND ENGINEERING, vol. 10, no. 25, 30 September 2010 (2010-09-30), pages 6146 - 6149, XP009506405, ISSN: 1671-1815
WANG LIYUAN ET AL.: "Progress of Studies on Molecualr Immunology of Outer Membrane Protein (OMP) of Salmonella Lignieres", CHINESE JOURNAL OF ZOONOSES, vol. 19, no. 4, 31 December 2003 (2003-12-31), pages 106 - 108, XP009506564, ISSN: 1002-2694
See also references of EP 3374491A4
KIKUCHI, FEMS MICROBIOLOGY LETTERS, vol. 173, 1999, pages 211 - 215
OGAWA-MIYATA ET AL., BIOSCI. BIOTECHNOL. BIOCHEM., vol. 65, 2001, pages 1149 - 1154
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
HENIKOFFHENIKOFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1989, pages 10915
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
PEARSONLIPMAN, PROC. NAT'L. ACAD SCI. USA, vol. 85, 1988, pages 2444
SAMBROOKRUSSELL: "Molecular Cloning, A Laboratory Manual", 2001
AUSUBEL: "Current Protocols in Molecular Biology", 2009, JOHN WILEY AND SONS
GALDIERO ET AL., CURR. PROT. PEPTIDESCI., vol. 13, 2012, pages 843 - 854
"PCR see PCR Protocols: A Guide to Methods and Applications", 1990, ACADEMIC PRESS
HENAUTDANCHIN ET AL.: "Escherichia coli and Salmonella", 1996, ASM PRES, pages: 2047 - 2066
NUCLEIC ACIDS RES., vol. 20, pages 2111 - 2118
NAKAMURA ET AL., NUCL. ACIDS RES., vol. 28, 2000, pages 292
JENSENHAMMER, APPL. ENVIRON. MICROBIOL., vol. 64, no. 82, pages 1998
SHIMADA ET AL., J. BACTERIOL., vol. 186, 2004, pages 7112
MIKSCH ET AL., PPL. MICROBIOL. BIOTECHNOL., vol. 69, 2005, pages 312
KANJEE, EMBO J., vol. 30, 2011, pages 931 - 944
LEMMONIERLANE, MICROBIOLOGYL, vol. 44, 1998, pages 751 - 760
SHAH ET AL., J. MED. SCI, vol. 2, 2002, pages 152 - 157
ANASTASSIADIA, S, RECENT PATENTS ON BIOTECHNOL., vol. 1, 2007, pages 11 - 24
KIND ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 91, 2011, pages 1287 - 1296
WANG LIYUAN ET AL.: "Progress of Studies on Molecualr Immunology of Outer Membrane Protein (OMP) of Salmonella Lignieres", CHINESE JOURNAL OF ZOONOSES, vol. 19, no. 4, 31 December 2003 (2003-12-31), pages 106 - 108, XP009506564, ISSN: 1002-2694
See also references of EP 3374491A4
KIKUCHI, FEMS MICROBIOLOGY LETTERS, vol. 173, 1999, pages 211 - 215
OGAWA-MIYATA ET AL., BIOSCI. BIOTECHNOL. BIOCHEM., vol. 65, 2001, pages 1149 - 1154
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
HENIKOFFHENIKOFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1989, pages 10915
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
PEARSONLIPMAN, PROC. NAT'L. ACAD SCI. USA, vol. 85, 1988, pages 2444
SAMBROOKRUSSELL: "Molecular Cloning, A Laboratory Manual", 2001
AUSUBEL: "Current Protocols in Molecular Biology", 2009, JOHN WILEY AND SONS
GALDIERO ET AL., CURR. PROT. PEPTIDESCI., vol. 13, 2012, pages 843 - 854
"PCR see PCR Protocols: A Guide to Methods and Applications", 1990, ACADEMIC PRESS
HENAUTDANCHIN ET AL.: "Escherichia coli and Salmonella", 1996, ASM PRES, pages: 2047 - 2066
NUCLEIC ACIDS RES., vol. 20, pages 2111 - 2118
NAKAMURA ET AL., NUCL. ACIDS RES., vol. 28, 2000, pages 292
JENSENHAMMER, APPL. ENVIRON. MICROBIOL., vol. 64, no. 82, pages 1998
SHIMADA ET AL., J. BACTERIOL., vol. 186, 2004, pages 7112
MIKSCH ET AL., PPL. MICROBIOL. BIOTECHNOL., vol. 69, 2005, pages 312
KANJEE, EMBO J., vol. 30, 2011, pages 931 - 944
LEMMONIERLANE, MICROBIOLOGYL, vol. 44, 1998, pages 751 - 760
SHAH ET AL., J. MED. SCI, vol. 2, 2002, pages 152 - 157
ANASTASSIADIA, S, RECENT PATENTS ON BIOTECHNOL., vol. 1, 2007, pages 11 - 24
KIND ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 91, 2011, pages 1287 - 1296
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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