Title:
MODIFIED MRI CONTRAST AGENTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/200615
Kind Code:
A3
Abstract:
The present disclosure generally provides compounds useful as MRI contrast agents. In some aspects, the disclosure provides MRI contrast agents that are chemically modified to have one or more moieties that include hydrophobic portions. In some aspects, the disclosure provides compositions that include such modified MRI contrast agents and a protein, such as albumin or albumin mimetics. Further, the disclosure provides various uses of these compounds and compositions.
Inventors:
LEGUYADER CLARE L M (US)
GIANNESCHI NATHAN C (US)
CALLMANN CASSANDRA E (US)
THOMPSON MATTHEW P (US)
DITRI TREFFLY (US)
BERTIN PAUL A (US)
GIANNESCHI NATHAN C (US)
CALLMANN CASSANDRA E (US)
THOMPSON MATTHEW P (US)
DITRI TREFFLY (US)
BERTIN PAUL A (US)
Application Number:
PCT/US2018/029271
Publication Date:
January 10, 2019
Filing Date:
April 25, 2018
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
VYBYL HOLDINGS INC (US)
VYBYL HOLDINGS INC (US)
International Classes:
A61K49/10; A61P35/00
Domestic Patent References:
| WO2008144728A1 | 2008-11-27 | |||
| WO2006095771A1 | 2006-09-14 |
Foreign References:
| US20040156785A1 | 2004-08-12 | |||
| US20030021750A1 | 2003-01-30 |
Other References:
OTHMAN, M. ET AL.: "Synthesis and physicochemical characterization of new squalenoyl amphiphilic gadolinium complexes as nanoparticle contrast agents", ORG. BIOMOL. CHEM., vol. 9, no. 11, 2011, pages 4367 - 4386, XP055561003
VERWILST, P. ET AL.: "Recent advances in Gd-chelate based bimodal optical/MRI contrast agents", CHEMICAL SOCIETY REVIEWS, vol. 44, no. 7, 2015, pages 1791 - 1806, XP055561004
ZHU, Q. ET AL.: "HP-D03A-based amphiphilic MRI contrast agents and relaxation enhancement through their assembly with polyelectrolytes", JOURNAL OF MATERIALS CHEMISTRY. B, MATERIALS FOR BIOLOGY AND MEDICINE, vol. 4, no. 45, 2016, pages 7241 - 7248, XP055561007
See also references of EP 3615088A4
VERWILST, P. ET AL.: "Recent advances in Gd-chelate based bimodal optical/MRI contrast agents", CHEMICAL SOCIETY REVIEWS, vol. 44, no. 7, 2015, pages 1791 - 1806, XP055561004
ZHU, Q. ET AL.: "HP-D03A-based amphiphilic MRI contrast agents and relaxation enhancement through their assembly with polyelectrolytes", JOURNAL OF MATERIALS CHEMISTRY. B, MATERIALS FOR BIOLOGY AND MEDICINE, vol. 4, no. 45, 2016, pages 7241 - 7248, XP055561007
See also references of EP 3615088A4
Attorney, Agent or Firm:
DAILEY, Robert S. (US)
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