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Title:
MODIFIED MSCL PROTEIN CHANNEL
Document Type and Number:
WIPO Patent Application WO2005051902
Kind Code:
A3
Abstract:
The invention relates to the field of drug delivery, in particular to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/ or localised release of therapeutic molecules (e.g. small molecules, peptides, proteins or other macromolecules). Provided are pH- and/or light-responsive compounds capable of controlling the channel activity of a mechanosensitive channel, such as the MscL channel protein of E.coli, or a functional equivalent thereof, and use of these compounds to convert a mechanosensitive channel protein into a pH- and/or light-responsive channel. Also provided are drug delivery vehicles comprising a pH- and/or light-responsive channel protein.

Inventors:
KOCER ARMAGAN (NL)
WALKO MARTIN (NL)
ROBILLARD GEORGE THOMAS (NL)
Application Number:
PCT/NL2004/000812
Publication Date:
October 27, 2005
Filing Date:
November 25, 2004
Export Citation:
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Assignee:
APPLIED NANOSYSTEMS BV (NL)
KOCER ARMAGAN (NL)
WALKO MARTIN (NL)
ROBILLARD GEORGE THOMAS (NL)
International Classes:
A61K9/127; A61K47/48; C07C381/04; (IPC1-7): C07C381/04; A61K9/127; A61K47/48; A61P35/00
Other References:
K. YOSHIMURA, ET AL.: "Chemically charging the pore constriction opens the mechanosensitive channel MscL", BIOPHYSICAL JOURNAL, vol. 80, no. 5, May 2001 (2001-05-01), BIOPHYSICAL SOCIETY, NEW YORK, US, pages 2198 - 2206, XP002278303, ISSN: 0006-3495
A.F. BATIZA, ET AL.: "Gating the bacterial mechanosensitive channel MscL in vivo", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 99, no. 8, 16 April 2002 (2002-04-16), NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, pages 5643 - 5648, XP002278316
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