MODIFIED NUCLEASES

CROSS-REFERENCE

[0001] This application claims priority to U.S. Provisional Application No. 63/185,315, filed May 6, 2021, and to U.S. Provisional Application No. 63/315,483, filed March 1, 2022, both of which are incorporated herein by reference.

BACKGROUND

[0002] Nucleic acid-guided nucleases have become important tools for research and genome engineering. The applicability of these tools can be limited by the sequence specificity requirements, expression, or delivery issues. INCORPORATION BY REFERENCE

[0003] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS [0004] The novel features of the invention are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings of which: [0005] Figure 1 shows a diagram of MAD7 comprising one or more nuclear localization signals (NLS).

[0006] Figure 2 shows editing frequency at the DNMT1 locus in and post-transfection cell viability of T-cell leukemic cells following treatment comprising one or more guide nucleic acids complexed with MAD7 comprising one or more NLS. [0007] Figure 3 shows editing frequency at the DNMT1 locus in T-cell leukemic cells using multiple electroporation programs in combination with the SE electroporation buffer.

[0008] Figure 4 shows editing frequency at the DNMT1 locus in T-cell leukemic cells using multiple electroporation programs in combination with the SF electroporation buffer.

[0009] Figure 5 shows editing frequency at the DNMT1 locus in T-cell leukemic cells using multiple electroporation programs in combination with the SG electroporation buffer.

[0010] Figure 6 shows editing frequency at the DNMT1 locus in T-cell leukemic cells using multiple electroporation programs. [0011] Figure 7shows editing frequency by type at eight loci in T-cell leukemic cells using multiple guide nucleic acids complexed with MAD7 comprising one or more NLS.

[0012] Figure 8 shows a comparison of editing efficiency between T-cell leukemic cells treated with MAD7 comprising one or more guide nucleic acids targeting the DNMT 1 locus as compared to a control guide nucleic acid binned by editing frequency.

[0013] Figure 9 shows editing frequency by PAM motif in T-cell leukemic cells using multiple guide nucleic acids complexed with MAD7 comprising one or more NLS.

[0014] Figure 10A shows sequence logo plots for multiple guide nucleic acids binned by editing frequency in T-cell leukemic cells using when complexed with MAD7 comprising one or more NLS.

[0015] Figure 10B shows nucleotide and dinucleotide frequency for multiple guide nucleic acids binned by editing frequency in T-cell leukemic cells using when complexed with MAD7 comprising one or more NLS.

[0016] Figure 11 shows trinucleotide AAA or UUU frequency binned by editing frequency in T-cell leukemic cells following treatment with multiple guide nucleic acids complexed with MAD7 comprising one or more NLS.

[0017] Figure 12 shows editing frequency for both INDELs and frameshift mutations at eight loci in T-cell leukemic cells following treatment with multiple guide nucleic acids complexed with MAD7 comprising one or more NLS. [0018] Figure 13 shows the correlation between INDEL frequency in the gNA validation experiment versus INDEL formation in the gNA screen experiment.

[0019] Figure 14 shows the proportion of frameshift to INDELs at eight loci in T-cell leukemic cells following treatment with multiple guide nucleic acids complexed with MAD7 comprising one or more NLS. [0020] Figure 15 shows INDEL frequency for gNAs comprising representative spacer sequences complexed with MAD7 comprising one or more NLS in T-cell leukemic cells at predicted off-target sites.

[0021] Figure 16 shows INDEL frequency for gNAs comprising representative spacer sequences complexed with MAD7 comprising one or more NLS in T-cell leukemic cells at predicted off-target sites.

[0022] Figure 17 shows INDEL frequency at the AAVS1 locus in T-cell leukemic cells following treatment with a gNA:MAD7 complex.

[0023] Figure 18 shows GFP insertion efficiency at the AAVS 1 locus and cell viability following treatment for multiple primer constructs. [0024] Figure 19 shows GFP insertion efficiency at the AAVS 1 locus with increasing concentrations of donor template (e.g., HDRT) and variable homology arm length.

[0025] Figure 20 shows CAR insertion efficiency at the AAVS 1 locus and cell viability with increasing concentrations of donor template and variable homology arm length.

[0026] Figure 21 shows CAR insertion efficiency (A) at the AAVS 1 locus and cell viability (B) in primary T-cells.

DETAILED DESCRIPTION

[0027] CRISPR is an abbreviation of Clustered Regularly Interspaced Short Palindromic Repeats. In a palindromic repeat, the sequence of nucleotides is the same in both directions.

Each of these palindromic repetitions is followed by short segments of spacer DNA. Small clusters of Cas (CRISPR-associated system) genes are located next to CRISPR sequences. The CRISPR/Cas system is a prokaryotic immune system that can confer resistance to foreign genetic elements such as those present within plasmids and phages providing the prokaryote a form of acquired immunity. RNA harboring a spacer sequence assists Cas (CRISPR-associated) proteins to recognize and cut exogenous DNA. CRISPR sequences are found in approximately 50% of bacterial genomes and nearly 90% of sequenced archaea has selected for efficient and robust metabolic and regulatory networks that prevent unnecessary metabolite biosynthesis and optimally distribute resources to maximize overall cellular fitness. The complexity of these networks with limited approaches to understand their structure and function and the ability to re program cellular networks to modify these systems for a diverse range of applications has complicated advances in this space. Certain approaches to re-program cellular networks are directed to modifying single genes of complex pathways but as a consequence of modifying single genes, unwanted modifications to the genes or other genes can result, getting in the way of identifying changes necessary to achieve a sought-after endpoint as well as complicating the endpoint sought by the modification.

[0028] CRISPR-Cas driven genome editing and engineering has dramatically impacted biology and biotechnology in general. CRISPR-Cas editing systems require a polynucleotide guided nuclease, a guide nucleic acid (gNA) e.g. a guide RNA (gRNA)) that directs the nuclease to cut a specific region of the genome, and, optionally, a donor DNA cassette (also referred to herein as a donor template or editing sequence) that can be used to repair the cut dsDNA and thereby incorporate programmable edits at the site of interest. The earliest demonstrations and applications of CRISPR-Cas editing used Cas9 nucleases and associated gRNA. These systems have been used for gene editing in a broad range of species encompassing bacteria to higher order mammalian systems such as animals and in certain cases, humans. It is well established, however, that important editing parameters such as protospacer adjacent motif (PAM) specificity, editing efficiency, and off-target rates, among others, are species, loci, and nuclease dependent. There is increasing interest in identifying and rapidly characterizing novel nuclease systems that can be exploited to broaden and improve overall editing capabilities.

[0029] One version of the CRISPR/Cas system, CRISPR/Cas9, has been modified to provide useful tools for editing targeted genomes. By delivering the Cas9 nuclease complexed with a synthetic guide RNA (gRNA) into a cell, the cell’s genome can be cut/edited at a predetermined location, allowing existing genes to be removed and/or new ones added. These systems are useful but have some important limitations regarding efficiency and accuracy of targeted editing, imprecise editing complications, as well as impediments when used for commercially relevant situations such as gene replacement. Therefore, a need exists for improved nucleic acid guided nuclease systems for directed and accurate editing with improved efficiency.

[0030] As used herein, the term “modulating” and “manipulating” of genome editing can mean an increase, a decrease, upregulation, downregulation, induction, a change in editing activity, a change in binding, a change cleavage or the like, of one or more of targeted genes or gene clusters of certain embodiments disclosed herein.

[0031] In certain embodiments of the present disclosure, there can be employed conventional molecular biology, microbiology, and recombinant DNA techniques within the skill of the art. Such techniques are explained fully in the literature and understood by those of skill in the art. [0032] In other embodiments, primers used herein for preparation per conventional techniques can include sequencing primers and amplification primers. In some embodiments, plasmids and oligomers used in conventional techniques can include synthesized oligomers and oligomer cassettes.

[0033] In some embodiments disclosed herein, nucleic acid-guided nuclease systems and methods of use are provided. A nuclease system can include transcripts and other elements involved in the expression of an engineered nuclease disclosed herein, which can include sequences encoding a novel engineered nucleic acid-guided nuclease protein and a guide sequence (gRNA) or a novel gRNA as disclosed herein. In some embodiments, nucleic acid- guided nuclease systems can include at least one CRISPR-associated nucleic acid guided nuclease construct, the disclosure of which are provided herein. In other embodiments, nucleic acid-guided nuclease systems can include at least one known guide sequence (gRNA) or at least one novel gRNA, such as a single gRNA or a dual gRNA. In some embodiments, an engineered nucleic acid-guided nuclease of the instant invention can be used in systems for editing a gene of interest in humans or other species. [0034] Bacterial and archaeal targetable nuclease systems have emerged as powerful tools for precision genome editing. However, naturally occurring nucleases have some limitations including expression and delivery challenges due to the nucleic acid sequence and protein size.

In certain embodiments, novel engineered nucleic acid-guided nuclease constructs disclosed herein can be created for targeting of a targeted gene and/or increased efficiency and/or accuracy of targeted gene editing in a subject.

[0035] In accordance with these embodiments, it is known that Casl2a is a single RNA- guided CRISPR/Cas endonuclease capable of genome editing having differing features when compared to Cas9. In certain embodiments, a Casl2a-based system allow fast and reliable introduction of donor DNA into a genome. In addition, Casl2a broadens genome editing. CRISPR/Casl2a genome editing has been evaluated in human cells as well as other organisms including plants. Several features of the CRISPR/Cas 12a system are different when compared to CRISPR/Cas9.

[0036] It is known that Casl2a nuclease recognizes T-rich protospacer adjacent motif (PAM) sequences (e.g. 5’-TTTN-3’ (AsCasl2a, LbCasl2a) and 5’-TTN-3’ (FnCasl2a); whereas, the comparable sequence for SpCas9 is NGG. The PAM sequence of Casl2a is located at the 5’ end of the target DNA sequence, where it is at the 3’ end for Cas9. In addition, Casl2a is capable of cleaving DNA distal to its PAM around the +18/+23 position of the protospacer. This cleavage creates a staggered DNA overhang (e.g. sticky ends), whereas Cas9 cleaves close to its PAM after the 3’ position of the protospacer at both strands and creates blunt ends. In certain methods, creating altered recognition of nucleases can provide an improvement over Cas9 or Casl2a to improve accuracy. Further, Casl2a is guided by a single crRNA and does not require a tracrRNA, resulting in a shorter gRNA sequence than the sgRNA used by Cas9. Surprisingly, it has been found that the modified Casl2a nucleases provided herein can also function with a dual gRNA.

[0037] It is also known that Casl2a displays additional ribonuclease activity that functions in crRNA processing. Casl2a is used as an editing tool for different species (e.g. S. cerevisiae), allowing the use of an alternative PAM sequence compared with the one recognized by CRISPR/Cas9. Novel nucleases disclosed herein can further recognize the same or alternative PAM sequences. These novel nucleases can provide an alternative system for multiplex genome editing as compared with known multiplex approaches and can be used as an improved system in mammalian gene editing.

[0038] Well-known Cas 12a protein-RNA complexes recognize a T-rich PAM and cleavage leads to a staggered DNA double-stranded break. Casl2a-type nuclease interacts with the pseudoknot structure formed by the 5 '-handle of crRNA. A guide RNA segment, composed of a seed region and the 3' terminus, possesses complementary binding sequences with the target

DNA sequences. Casl2a type nucleases characterized to date have been demonstrated to work with a single gRNA and to process gRNA arrays. While Casl2a-type and Cas9 nuclease systems have proven highly impactful, neither system has been demonstrated to function as predictably as is desired to enable the full range of applications envisioned for gene-editing technologies.

[0039] In the current state, a range of efforts have attempted to engineer improved CRISPR editing systems having increased efficiency and accuracy, which have included engineering of the PAM specificity, stability, and sequence of the gRNA and-or the nuclease. For example, chemical modifications of CRISPR/Cas9 gRNA expected to increase gRNA stability was found to lead to a 3.8-fold higher indel frequencies in human cells. In addition, other studies included structure-guided mutagenesis of Casl2a and screened to identify variants with an increased range of recognized PAM sequences. These engineered AsCasl2a recognized TYCV and TATV PAMs in addition to the established TTTV sequence, with enhanced activities in vitro and in tested human cells.

[0040] In certain embodiments, Casl2a-like nucleases and engineered gRNAs disclosed herein are contemplated for use in bacteria, and other prokaryotes. In certain embodiments, engineered designer nucleases are contemplated for use in eukaryotes such as yeast, mammals, e.g., human as well as of use in birds and fish, or cells derived from same.

[0041] In some embodiments, off-targeting rates for nuclease constructs disclosed herein can be reduced compared to a control, e.g., a native sequence, for improved editing. Off-targeting rates can be readily tested.

[0042] In some embodiments, nuclease constructs disclosed herein can share conserved encoded motifs of known nucleases. In other embodiments, nuclease constructs disclosed herein do not share conserved encoded peptide motifs with known nucleases. In preferred embodiments, provided herein are compositions, methods, and/or kits wherein the CRISPR nuclease comprises a Type V nuclease. In certain embodiments, provided herein are compositions, methods, and/or kits wherein the CRISPR nuclease comprises a Type V-A, V-B, V-C, V-D, or V-E CRISPR nuclease. In certain embodiments, provided herein are compositions, methods, and/or kits wherein the CRISPR nuclease comprises a Type V-A nuclease. Naturally occurring type V-A CRISPR nucleases comprise a RuvC-like nuclease domain but lack an HNH endonuclease domain, and recognize a 5 ’ T -rich PAM located immediately upstream from the target nucleotide sequence, the orientation determined using the non-target strand (i.e., the strand not hybridized with the spacer sequence) as the coordinate. These CRISPR nucleases cleave a double-stranded DNA to generate a staggered double-stranded break rather than a blunt end. The cleavage site is distant from the PAM site (e.g., separated by at least 10, 11, 12, 13, 14, or 15 nucleotides downstream from the PAM on the non-target strand and/or separated by at least 15, 16, 17, 18, or 19 nucleotides upstream from the sequence complementary to PAM on the target strand).

[0043] In certain embodiments, a type V-A CRISPR nuclease comprises Cpfl. Cpfl proteins are known in the art and are described, e.g., in U.S. Patent Nos. 9,790,490 and 10,113,179. Cpfl orthologs can be found in various bacterial and archaeal genomes. For example, in certain embodiments, the Cpfl protein is derived from Francisella novicida U112 (Fn), Acidaminococcus sp. BV3L6 (As), Lachnospiraceae bacterium ND2006 (Lb), Lachnospiraceae bacterium MA2020 (Lb2), Candidatus Methanoplasma termitum (CMt), Moraxella bovoculi 237 (Mb), Porphyromonas crevioricanis (Pc), Prevotella disiens (Pd), Francisella tularensis 1 , Francisella tularensis subsp. novicida, Prevotella albensis, Lachnospiraceae bacterium MC2017 1, Butyrivibrio proteoclasticus, Peregrinibacteria bacterium GW2011 GWA2 33 10, Parcubacteria bacterium GW2011 GWC2 44 17, Smithella sp. SCADC, Eubacterium eligens, Leptospira inadai, Porphyromonas macacae, Prevotella bryantii, Proteocatella sphenisci, Anaerovibrio sp. RM50 , Moraxella caprae, Lachnospiraceae bacterium COE1, or Eubacterium coprostanoligenes .

[0044] In certain embodiments, a type V-A CRISPR nuclease comprises AsCpfl or a variant thereof. In certain embodiments, a type V-A CRISPR nucleases comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 3 of International (PCT) Application Publication No. WO 2021/158918. In certain embodiments, a type V-A CRISPR nucleases comprises the amino acid sequence set forth in SEQ ID NO: 3 of International (PCT) Application Publication No. WO 2021/158918.

[0045] In certain embodiments, a type V-A CRISPR nuclease comprises LbCpfl or a variant thereof. In certain embodiments, a type V-A CRISPR nucleases comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 4 of International (PCT) Application Publication No. WO 2021158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 4 of International (PCT) Application Publication No. WO 2021/158918.

[0046] In certain embodiments, a type V-A CRISPR nuclease comprises FnCpfl or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%,

98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 5 of International (PCT) Application Publication No. WO 2021158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 5 of International (PCT) Application Publication No. WO 2021/158918.

[0047] In certain embodiments, a type V-A CRISPR nuclease comprises Prevotella hryantii Cpfl (PbCpfl) or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 6 of International (PCT) Application Publication No. WO 2021/158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 6 of International (PCT) Application Publication No. WO 2021/158918.

[0048] In certain embodiments, a type V-A CRISPR nuclease comprises Proteocatella sphenisci Cpfl (PsCpfl) or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 7 of International (PCT) Application Publication No. WO 2021158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 7 of International (PCT) Application Publication No. WO 2021/158918.

[0049] In certain embodiments, a type V-A CRISPR nuclease comprises Anaerovibrio sp. RM50 Cpfl (As2Cpfl) or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 8 of International (PCT) Application Publication No. WO 2021158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 8 of International (PCT) Application Publication No. WO 2021/158918.

[0050] In certain embodiments, a type V-A CRISPR nuclease comprises Moraxella caprae Cpfl (McCpfl) or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 9 of International (PCT) Application Publication No. WO 2021/158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 9 of International (PCT) Application Publication No. WO 2021/158918.

[0051] In certain embodiments, a type V-A CRISPR nuclease comprises Lachnospiraceae bacterium COE1 Cpfl (Lb3Cpfl) or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 10 of International (PCT) Application Publication No. WO 2021158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 10 of International (PCT) Application Publication No. WO 2021/158918.

[0052] In certain embodiments, a type V-A CRISPR nuclease comprises Eubacterium coprostanoli genes Cpfl (EcCpfl) or a variant thereof. In certain embodiments, a type V-A Cas protein comprises an amino acid sequence at least 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence set forth in SEQ ID NO: 11 of International (PCT) Application Publication No. WO 2021158918. In certain embodiments, a type V-A Cas protein comprises the amino acid sequence set forth in SEQ ID NO: 11 of International (PCT) Application Publication No. WO 2021/158918.

[0053] In certain embodiments, a type V-A CRISPR nuclease is not Cpfl. In certain embodiments, a type V-A CRISPR nuclease is not AsCpfl.

[0054] In certain embodiments, a type V-A CRISPR nuclease comprises a Type V-A nuclease described in U.S. Patent No. 9,982,279.

[0055] In certain embodiments, a Type VA CRISPR nuclease polypeptide used in compositions and methods herein can be represented by a polypeptide that includes a sequence that has at least 60, 70, 80, 85, 90, 95, 96, 97, 98, 99, or 100% sequence identity, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% sequence identity with SEQ ID NO: 1 SEQ ID NO: 1 wherein the Type VA CRISPR nuclease polypeptide further comprises at least one, two, three, four, five or six nuclear localization sequences (NLS), each of which can be at or near the amino end or carboxy end of the CRISPR nuclease polypeptide; and/or one or more purification tags; in addition, a cleavage sequence can be provided to remove portions of a protopeptide. As used herein, the term “at or near” an N-terminus or a C-terminus includes where the nearest amino acid of the NLS to the N- or C-terminus is within 300 amino acids, in some cases within 200 amino acids, from the N- or C-terminus of the polypeptide (e.g., a core polypeptide such as one of the CRISPR nucleases described herein, to which the NLS or NLSs is attached). In certain emobidments, a Type V CRISPR nuclease polypeptide, e.g., Type Va CRISPR polypeptide, comprises two, three, four, or five NLSs, each of which are at or near the N-terminus or the C-terminus of the polypeptide, in preferred embodiments the NLSs are at or near the N-terminus. In certain embodiments, a CRISPR nuclease polypeptide, including one or more NLSs and, in some cases, a purification tag and/or a cleavage site, comprises a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to any one of SEQ ID NOs: 109-112. In certain embodiments, a Type V, e.g., VA CRISPR nuclease polypeptide comprises at least 1-30, 1-20, 1- 15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 2-30, 2-20, 2-15, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 3-30, 3-20, 3-15, 3-10, 3-9, 3-8, 3-7, 3-6, or 3-5, preferably 1-10, more preferably 2-10, even more preferably 3-10 NLSs, each of which is at or near the N-terminus or the C-terminus of the polypeptide, in preferred embodiments at or near the N-terminus. In certain embodiments, at least two, or at least three, of the NLSs have different mechanisms, that is, different mechanisms by which they localize an attached polypeptide to a nucleus. Such mechanisms are well-known in the art; see, e.g., Lu et al. Cell Commun Signal (2021) 19:60 hftpsV/doLorg/IO.1186/s 12964 -021 -0074 ! -y. Suitable NLS, purification tag, and cleavage site sequences can be as described elsewhere herein, e.g., in sections labled Nuclear Localization Signals, Purification Tags, and Cleavage Sites.

[0056] SEQ ID NO:l

MNNGTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGIIKEDELRGENRQILKDI MDDY

YRGFISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKEQTEYRKAIHKKFANDDR FKN

MFSAKLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSFKDYFKNRANCFSAD DISSS

SCHRIVNDNAEIFFSNALVYRRIVKSLSNDDINKISGDMKDSLKEMSLEEIYSYEKY GEFI

TQEGISFYNDICGKVNSFMNLYCQKNKENKNLYKLQKLHKQILCIADTSYEVPYKFE SD

EEVYQSVNGFLDNISSKHIVERLRKIGDNYNGYNLDKIYIVSKFYESVSQKTYRDWE TIN

TALEIHYNNILPGNGKSKADKVKKAVKNDLQKSITEINELVSNYKLCSDDNIKAETY IHEI

SHILNNFEAQELKYNPEIHLVESELKASELKNVLDVIMNAFHWCSVFMTEELVDKDN NF

YAELEEIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFGIPTLADGWSKSKEYSNN AIIL

MRDNLYYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLLPGPNKMIPKVFLSSKT GV

ET YKP S A YILEGYKQNKHIKS SKDFDITFCHDLID YFKNCIAIHPEWKNF GFDF SDTS TYE

DIS GF YREVELQGYKIDWT YISEKDIDLLQEKGQL YLFQI YNKDF SKKS T GNDNLHTM YL

KNLFSEENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILVNRTYEAEEKDQFGNI QIVRK

NIPENIY QELYKYFNDKSDKELSDEAAKLKNVV GHHEAATNIVKDYRYTYDKYFLHMPI

TINFKANKTGFINDRILQYIAKEKDLHVIGIDRGERNLIYVSVIDTCGNIVEQKSFN IVNGY

DYQIKLKQQEGARQIARKEWKEIGKIKEIKEGYLSLVIHEISKMVIKYNAIIAMEDL SYGF

KKGRFKVERQVYQKFETMLINKLNYLVFKDISITENGGLLKGYQLTYIPDKLKNVGH QC

GCIFYVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKFDSIRYDSEKNLFCFTF DYNN

FITQNTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDTIDITKDMEKTLEMTDINWRD GH

DLRQDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLISPVLNENNIFYDSAKA GDALP

KDADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISNKDWFDFIQNKRYL

[0057] Nucleotide sequences coding for SEQ ID NO: 1 can include sequences with less than

99, 95, 90, 85, 80, 75, 70, 65, 60, 55, 50, 45, or 40% sequence identity with SEQ ID NO: 22, in preferred embodiments less than 75% sequence identity. . In certain embodiments, a nucleotide sequence coding for SEQ ID NO: 1 can also include nucleic acid sequences coding for one or more NLS at the N-terminus and/or C-terminus, as described herein, and/or a tag such as a purification tag at the N-terminus, as described herein. In certain embodiments, provided herein are compositions comprising a first polynucleotide coding for a polypeptide comprising a nucleic acid-guided nuclease comprising a CRISPR Type V nuclease polypeptide, wherein the polynucleotide has less than 75% sequence identity to SEQ ID NO: 22, such as wherein the nuclease polypeptide comprises at least 1, 2, 3, 4, or 5 NLSs, wherein each of the NLSs is at or near the N-terminus or the C-terminus of the nuclease polypeptide. NLSs can be any of those described herein. The first polynucleotide can comprise a sequence coding for a purification tag, such as a purification tag described herein, and/or cleavage site, such as a cleavage site described herein. In certain embodiments the first polynucleotide codes for a polypeptide comprising a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to any one of SEQ ID NOs: 109-112, such as SEQ ID NO: 109, or SEQ ID NO:

110, or SEQ ID NO: 111, or SEQ ID NO: 112. the first polynucleotide comprises a sequence at least 50, 60, 70, 80, 90, 95, 97, or 99% identical, or 100% identical , preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 113. In certain embodiment the composition further comprises a second polynucleotide coding for a gNA or portion thereof, wherein the gNA, e.g., gRNA, comprises a spacer sequence that targets a target nucleotide sequence within a polynucleotide, or a polynuclotide coding for the gNA, e.g., gRNA, wherein the gNA, e.g., gRNA is compatible with the Type V CRISPR nuclease. In certain embodiments the first and second polynucleotides are the same. The composition can further comprise a third polynucleotide comprising a donor template. In certain embodiments, provided is a vector comprising one of the polynucleotide compositions of this paragraph. In certain embodiments, provided is a cell comprising one of the polynucleotide compositions of this paragraph, e.g., a human cell, such as an immune cell, for example a T cell, or a stem cell, such as an iPSC. In certain embodiments, provided is a method comprising inserting any one of the polynucleotide compositions of this paragraph into a cell. In certain embodiments inserting the composition comprises electroporation.

[0058] SEQ ID NO: 22:

ATGAACAACGGCACAAATAATTTTCAGAACTTCATCGGGATCTCAAGTTTGCAGAAA

ACGCTGCGCAATGCTCTGATCCCCACGGAAACCACGCAACAGTTCATCGTCAAGAA

CGGAATAATTAAAGAAGATGAGTTACGTGGCGAGAACCGCCAGATTCTGAAAGATA

TCATGGATGACTACTACCGCGGATTCATCTCTGAGACTCTGAGTTCTATTGATGACA

TAGATTGGACTAGCCTGTTCGAAAAAATGGAAATTCAGCTGAAAAATGGTGATAAT AAAGATACCTTAATTAAGGAACAGACAGAGTATCGGAAAGCAATCCATAAAAAATT

TGCGAACGACGATCGGTTTAAGAACATGTTTAGCGCCAAACTGATTAGTGACATATT

ACCTGAATTTGTCATCCACAACAATAATTATTCGGCATCAGAGAAAGAGGAAAAAA

CCCAGGTGATAAAATTGTTTTCGCGCTTTGCGACTAGCTTTAAAGATTACTTCAAGA

ACCGTGCAAATTGCTTTTCAGCGGACGATATTTCATCAAGCAGCTGCCATCGCATCG

TCAACGACAATGCAGAGATATTCTTTTCAAATGCGCTGGTCTACCGCCGGATCGTAA

AATCGCTGAGCAATGACGATATCAACAAAATTTCGGGCGATATGAAAGATTCATTA

AAAGAAATGAGTCTGGAAGAAATATATTCTTACGAGAAGTATGGGGAATTTATTAC

CCAGGAAGGCATTAGCTTCTATAATGATATCTGTGGGAAAGTGAATTCTTTTATGAA

CCTGTATTGTCAGAAAAATAAAGAAAACAAAAATTTATACAAACTTCAGAAACTTC

ACAAACAGATTCTATGCATTGCGGACACTAGCTATGAGGTCCCGTATAAATTTGAAA

GTGACGAGGAAGTGTACCAATCAGTTAACGGCTTCCTTGATAACATTAGCAGCAAA

CATATAGTCGAAAGATTACGCAAAATCGGCGATAACTATAACGGCTACAACCTGGA

TAAAATTTATATCGTGTCCAAATTTTACGAGAGCGTTAGCCAAAAAACCTACCGCGA

CTGGGAAACAATTAATACCGCCCTCGAAATTCATTACAATAATATCTTGCCGGGTAA

CGGTAAAAGTAAAGCCGACAAAGTAAAAAAAGCGGTTAAGAATGATTTACAGAAAT

CCATCACCGAAATAAATGAACTAGTGTCAAACTATAAGCTGTGCAGTGACGACAAC

ATCAAAGCGGAGACTTATATACATGAGATTAGCCATATCTTGAATAACTTTGAAGCA

CAGGAATTGAAATACAATCCGGAAATTCACCTAGTTGAATCCGAGCTCAAAGCGAG

TGAGCTTAAAAACGTGCTGGACGTGATCATGAATGCGTTTCATTGGTGTTCGGTTTT T

ATGACTGAGGAACTTGTTGATAAAGACAACAATTTTTATGCGGAACTGGAGGAGAT

TTACGATGAAATTTATCCAGTAATTAGTCTGTACAACCTGGTTCGTAACTACGTTAC C

CAGAAACCGTACAGCACGAAAAAGATTAAATTGAACTTTGGAATACCGACGTTAGC

AGACGGTTGGTCAAAGTCCAAAGAGTATTCTAATAACGCTATCATACTGATGCGCGA

CAATCTGTATTATCTGGGCATCTTTAATGCGAAGAATAAACCGGACAAGAAGATTAT

CGAGGGTAATACGTCAGAAAATAAGGGTGACTACAAAAAGATGATTTATAATTTGC

TCCCGGGTCCCAACAAAATGATCCCGAAAGTTTTCTTGAGCAGCAAGACGGGGGTG

GAAACGTATAAACCGAGCGCCTATATCCTAGAGGGGTATAAACAGAATAAACATAT

CAAGTCTTCAAAAGACTTTGATATCACTTTCTGTCATGATCTGATCGACTACTTCAA A

AACTGTATTGCAATTCATCCCGAGTGGAAAAACTTCGGTTTTGATTTTAGCGACACC

AGTACTTATGAAGACATTTCCGGGTTTTATCGTGAGGTAGAGTTACAAGGTTACAAG

ATTGATTGGACATACATTAGCGAAAAAGACATTGATCTGCTGCAGGAAAAAGGTCA

ACTGTATCTGTTCCAGATATATAACAAAGATTTTTCGAAAAAATCAACCGGGAATGA

CAACCTTCACACCATGTACCTGAAAAATCTTTTCTCAGAAGAAAATCTTAAGGATAT

CGTCCTGAAACTTAACGGCGAAGCGGAAATCTTCTTCAGGAAGAGCAGCATAAAGA ACCCAATCATTCATAAAAAAGGCTCGATTTTAGTCAACCGTACCTACGAAGCAGAA

GAAAAAGACCAGTTTGGCAACATTCAAATTGTGCGTAAAAATATTCCGGAAAACAT

TTATCAGGAGCTGTACAAATACTTCAACGATAAAAGCGACAAAGAGCTGTCTGATG

AAGCAGCCAAACTGAAGAATGTAGTGGGACACCACGAGGCAGCGACGAATATAGTC

AAGGACTATCGCTACACGTATGATAAATACTTCCTTCATATGCCTATTACGATCAAT

TTCAAAGCCAATAAAACGGGTTTTATTAATGATAGGATCTTACAGTATATCGCTAAA

GAAAAAGACTTACATGTGATCGGCATTGATCGGGGCGAGCGTAACCTGATCTACGT

GTCCGTGATTGATACTTGTGGTAATATAGTTGAACAGAAAAGCTTTAACATTGTAAA

CGGCTACGACTATCAGATAAAACTGAAACAACAGGAGGGCGCTAGACAGATTGCGC

GGAAAGAATGGAAAGAAATTGGTAAAATTAAAGAGATCAAAGAGGGCTACCTGAG

CTTAGTAATCCACGAGATCTCTAAAATGGTAATCAAATACAATGCAATTATAGCGAT

GGAGGATTTGTCTTATGGTTTTAAAAAAGGGCGCTTTAAGGTCGAACGGCAAGTTTA

CCAGAAATTTGAAACCATGCTCATCAATAAACTCAACTATCTGGTATTTAAAGATAT

TTCGATTACCGAGAATGGCGGTCTCCTGAAAGGTTATCAGCTGACATACATTCCTGA

TAAACTTAAAAACGTGGGTCATCAGTGCGGCTGCATTTTTTATGTGCCTGCTGCATA

CACGAGCAAAATTGATCCGACCACCGGCTTTGTGAATATCTTTAAATTTAAAGACCT

GACAGTGGACGCAAAACGTGAATTCATTAAAAAATTTGACTCAATTCGTTATGACAG

TGAAAAAAATCTGTTCTGCTTTACATTTGACTACAATAACTTTATTACGCAAAACAC

GGTCATGAGCAAATCATCGTGGAGTGTGTATACATACGGCGTGCGCATCAAACGTC

GCTTTGTGAACGGCCGCTTCTCAAACGAAAGTGATACCATTGACATAACCAAAGATA

TGGAGAAAACGTTGGAAATGACGGACATTAACTGGCGCGATGGCCACGATCTTCGT

CAAGACATTATAGATTATGAAATTGTTCAGCACATATTCGAAATTTTCCGTTTAACA

GTGCAAATGCGTAACTCCTTGTCTGAACTGGAGGACCGTGATTACGATCGTCTCATT

TCACCTGTACTGAACGAAAATAACATTTTTTATGACAGCGCGAAAGCGGGGGATGC

ACTTCCTAAGGATGCCGATGCAAATGGTGCGTATTGTATTGCATTAAAAGGGTTATA

TGAAATTAAACAAATTACCGAAAATTGGAAAGAAGATGGTAAATTTTCGCGCGATA

AACTCAAAATCAGCAATAAAGATTGGTTCGACTTTATCCAGAATAAGCGCTATCTCT

AA

[0059] Exemplary nucleotide sequences coding for SEQ ID NO: 1 can include, e.g., SEQ ID NOs: 23-42:

[0060] SEQ ID NO: 23

ATGAACAACGGAACAAATAATTTTCAGAACTTTATTGGGATCAGTTCGCTTCAGAAA

ACGCTTCGTAATGCTCTGATTCCCACAGAAACCACTCAGCAGTTTATCGTAAAGAAT

GGCATTATCAAGGAGGATGAATTACGCGGCGAGAACCGCCAAATCTTAAAAGATAT

CATGGACGACTACTACCGCGGTTTCATTAGCGAAACTCTTAGTTCAATTGACGACAT TGACTGGACGTCCTTGTTCGAAAAGATGGAGATTCAATTAAAGAACGGTGATAACA

AGGATACGTTGATTAAAGAACAGACGGAGTACCGTAAGGCTATCCACAAAAAATTT

GCAAACGACGACCGCTTTAAAAATATGTTTAGCGCAAAATTAATCTCCGACATCCTG

CCTGAATTCGTCATCCATAACAATAACTATAGCGCCTCGGAAAAAGAAGAAAAAAC

GCAGGTTATTAAACTTTTCTCGCGCTTTGCAACAAGCTTTAAGGATTACTTCAAAAA

TCGCGCCAATTGTTTTTCAGCCGACGACATTAGCTCCAGTTCCTGCCACCGTATTGT G

AATGACAACGCTGAGATTTTTTTTTCCAATGCGCTGGTTTATCGTCGTATTGTTAAG A

GCCTTAGTAACGACGACATTAATAAAATTAGCGGTGATATGAAGGATAGCTTGAAA

GAAATGAGTCTGGAAGAGATCTATAGTTACGAGAAGTACGGCGAATTTATTACCCA

GGAGGGCATTTCATTTTACAATGATATCTGTGGAAAAGTCAACTCCTTTATGAACTT

GTATTGCCAAAAGAATAAAGAAAACAAAAACCTGTACAAACTGCAAAAGTTACACA

AGCAGATTTTGTGTATCGCAGACACGTCATACGAAGTACCGTACAAGTTTGAGTCCG

ATGAAGAAGTGTACCAAAGCGTTAATGGCTTTTTGGATAACATTTCGAGCAAACATA

TCGTAGAGCGTTTGCGTAAGATTGGTGATAATTACAACGGTTACAATTTAGACAAAA

TCTATATCGTCTCTAAGTTTTACGAAAGTGTTTCTCAGAAAACTTACCGCGATTGGG

AGACGATCAACACTGCGCTGGAGATTCATTACAATAATATCCTTCCAGGTAACGGTA

AAAGCAAAGCTGATAAGGTGAAAAAGGCGGTTAAAAATGACCTTCAAAAGTCTATC

ACAGAAATCAACGAATTGGTCAGCAATTATAAGCTTTGCAGTGACGATAACATTAA

GGCCGAGACTTACATCCATGAGATCTCTCACATTCTTAATAATTTTGAAGCGCAAGA

GCTGAAATACAATCCTGAAATCCATCTGGTCGAAAGTGAATTAAAAGCCTCCGAATT

AAAAAATGTCTTGGACGTGATCATGAATGCGTTCCATTGGTGCTCAGTTTTTATGAC

GGAAGAGTTGGTGGACAAAGACAACAATTTTTACGCCGAGCTTGAGGAAATTTACG

ACGAAATTTACCCCGTTATTTCGTTATACAACCTTGTGCGTAATTACGTTACACAAA

AGCCCTATTCGACAAAGAAAATCAAGTTAAATTTCGGGATTCCCACATTAGCTGATG

GATGGTCCAAATCCAAAGAATACTCGAATAACGCTATCATCCTTATGCGTGATAATT

TGTACTACTTAGGCATCTTCAATGCGAAGAACAAACCTGACAAGAAAATTATCGAA

GGAAACACTTCGGAGAACAAAGGTGATTATAAAAAGATGATCTACAACTTGCTTCC

CGGGCCAAACAAAATGATTCCCAAGGTATTTTTGAGTTCTAAAACCGGTGTCGAAAC

TTACAAACCAAGTGCTTATATTTTGGAAGGATACAAACAGAACAAACATATCAAGT

CTTCGAAAGACTTCGATATTACGTTCTGCCACGATCTGATCGATTACTTCAAGAACT

GTATTGCTATTCACCCCGAGTGGAAGAACTTTGGATTTGATTTCTCCGACACGTCCA

CTTATGAAGATATCTCTGGCTTCTATCGCGAGGTTGAATTACAAGGGTATAAGATTG

ACTGGACTTATATTTCGGAGAAGGATATCGATCTTTTGCAAGAAAAAGGGCAACTTT

ATTTATTTCAGATCTATAACAAGGACTTTTCAAAAAAGAGCACTGGAAATGACAATC

TGCATACCATGTACCTTAAGAACCTGTTCTCGGAAGAGAACCTGAAGGACATTGTAC TTAAACTGAATGGAGAGGCAGAGATCTTCTTTCGCAAATCAAGCATTAAGAACCCA

ATTATTCACAAAAAGGGGAGTATCTTAGTAAATCGCACATATGAGGCTGAGGAAAA

AGATCAGTTTGGTAACATTCAGATCGTGCGTAAGAACATTCCTGAAAATATCTATCA

GGAACTTTATAAGTATTTCAACGATAAAAGTGATAAAGAGCTGAGTGACGAAGCGG

CTAAACTTAAGAATGTTGTGGGACACCATGAGGCAGCAACCAATATTGTGAAGGAT

TATCGCTATACGTACGACAAATACTTTTTACACATGCCCATCACTATTAATTTTAAA G

CTAATAAGACTGGCTTCATTAACGATCGCATCCTGCAGTACATTGCTAAGGAAAAGG

ATCTTCACGTTATCGGTATCGATCGCGGGGAGCGTAATCTTATCTACGTCTCTGTCA T

TGACACGTGTGGCAATATTGTGGAGCAAAAGTCCTTCAATATTGTTAACGGCTATGA

CTATCAGATTAAATTGAAACAGCAGGAAGGTGCGCGTCAGATTGCCCGCAAGGAAT

GGAAGGAAATTGGCAAGATCAAAGAAATTAAGGAGGGCTACTTAAGCTTAGTAATT

CACGAAATTAGTAAAATGGTTATCAAATACAACGCCATCATCGCGATGGAGGATCTT

TCGTACGGGTTTAAGAAAGGTCGTTTTAAAGTGGAGCGTCAGGTGTACCAGAAATTT

GAAACTATGCTTATTAACAAACTTAACTACCTGGTTTTCAAGGATATCAGTATTACT

GAAAACGGGGGGCTGTTAAAAGGGTATCAATTAACTTACATTCCAGACAAATTAAA

GAACGTTGGACATCAGTGTGGCTGCATTTTTTATGTACCAGCTGCATACACTTCAAA

GATCGATCCTACGACTGGGTTCGTGAACATTTTTAAGTTTAAAGACTTGACGGTAGA

TGCCAAGCGCGAATTCATCAAGAAATTCGACAGCATTCGCTACGACTCTGAGAAAA

ATCTTTTCTGTTTCACATTCGATTATAACAATTTCATTACGCAGAACACAGTAATGT C

CAAGTCTTCTTGGAGTGTTTATACATATGGTGTCCGCATTAAGCGCCGTTTCGTCAA C

GGCCGCTTCAGTAATGAGAGCGATACTATTGACATCACAAAAGACATGGAAAAAAC

ACTGGAAATGACCGACATCAATTGGCGTGACGGCCATGACTTACGTCAGGATATCAT

TGATTATGAGATCGTTCAACACATCTTCGAAATCTTTCGCTTGACTGTTCAAATGCG C

AATTCCTTGTCGGAATTGGAGGACCGTGATTATGACCGCTTAATTTCCCCCGTCTTA A

ATGAAAACAATATTTTTTATGACTCTGCAAAAGCTGGAGATGCTCTGCCGAAAGACG

CCGATGCAAATGGGGCATATTGCATTGCTTTAAAGGGGCTTTACGAGATCAAGCAA

ATCACCGAAAACTGGAAAGAGGATGGAAAGTTTTCGCGTGATAAACTGAAGATCTC

TAACAAAGACTGGTTCGACTTTATCCAGAACAAGCGTTATTT

[0061] SEQ ID NO: 24

ATGAACAACGGCACCAATAACTTCCAAAACTTCATCGGGATCTCTAGCCTTCAGAAG

ACGCTTCGCAATGCTCTTATCCCAACTGAGACCACTCAACAATTTATTGTGAAGAAT

GGAATTATTAAAGAGGACGAACTGCGTGGCGAGAATCGTCAGATCTTAAAGGACAT

TATGGATGATTATTACCGTGGATTCATCTCCGAAACATTATCGTCGATCGATGATAT

CGATTGGACTTCTCTGTTCGAGAAAATGGAAATTCAATTGAAAAACGGAGATAATA

AAGATACGCTTATCAAAGAACAGACGGAATATCGTAAAGCGATTCATAAGAAATTC GCAAATGACGATCGTTTCAAAAATATGTTCAGTGCCAAGCTTATTTCGGACATTTTA

CCTGAATTTGTAATTCATAATAATAACTACTCAGCAAGTGAGAAGGAGGAGAAAAC

CCAAGTTATTAAACTGTTCTCTCGTTTCGCAACGTCCTTTAAAGATTACTTTAAAAA C

CGCGCGAATTGCTTTAGCGCTGACGACATTTCCAGCTCATCCTGTCATCGCATCGTA

AACGACAATGCGGAAATCTTCTTCAGCAACGCCCTGGTTTACCGCCGCATCGTCAAA

AGCTTATCGAATGACGACATCAATAAGATCTCAGGAGATATGAAGGACTCGCTTAA

GGAGATGTCTCTGGAGGAAATTTATAGTTACGAAAAGTATGGAGAGTTCATTACCCA

GGAGGGAATCTCGTTCTACAATGACATTTGCGGGAAGGTGAACTCCTTCATGAACTT

ATACTGCCAGAAAAACAAAGAGAACAAAAATCTGTATAAATTGCAGAAATTACATA

AACAGATTCTTTGTATTGCTGACACTTCCTACGAAGTACCCTATAAATTCGAGTCAG

ATGAAGAAGTATACCAGTCCGTGAACGGATTTCTGGACAATATCTCCTCAAAACACA

TCGTGGAACGCTTACGTAAAATTGGCGATAATTATAATGGTTACAATCTTGACAAAA

TTTATATCGTATCTAAATTTTACGAGAGTGTGAGCCAAAAGACCTACCGCGACTGGG

AGACCATCAACACAGCTTTAGAAATTCACTATAATAATATCTTACCCGGCAATGGTA

AGAGCAAGGCTGACAAGGTAAAAAAGGCCGTCAAGAATGATTTGCAGAAATCTATT

ACAGAAATTAATGAGTTAGTCTCCAACTATAAGCTTTGTTCCGACGATAACATCAAA

GCTGAGACATATATTCATGAGATTAGTCACATTCTTAACAACTTCGAGGCCCAGGAA

CTTAAGTACAATCCTGAAATTCATCTTGTCGAGTCTGAGCTGAAAGCTAGTGAATTG

AAAAATGTTTTAGACGTTATTATGAACGCATTCCACTGGTGCTCTGTGTTTATGACA

GAAGAACTGGTCGACAAGGACAATAACTTCTATGCCGAACTTGAGGAAATCTACGA

TGAAATTTACCCTGTAATCTCCTTGTATAATCTTGTACGTAATTACGTCACTCAAAA A

CCTTACAGCACGAAAAAAATTAAATTGAACTTCGGGATTCCTACACTTGCCGACGGG

TGGTCTAAATCCAAGGAATATAGCAACAATGCCATTATTTTAATGCGCGACAATCTT

TACTATTTAGGAATTTTTAACGCTAAGAACAAGCCCGATAAAAAGATTATTGAAGGA

AACACGTCTGAAAATAAGGGCGACTACAAAAAGATGATTTATAACCTTTTGCCCGGT

CCAAACAAAATGATCCCAAAGGTATTCCTGTCATCCAAAACAGGGGTTGAGACATA

TAAGCCCAGCGCATATATTCTGGAAGGATACAAACAGAATAAACATATCAAAAGCA

GCAAAGATTTTGACATTACTTTTTGCCACGATTTAATCGACTACTTCAAAAACTGTA T

CGCTATCCACCCTGAATGGAAGAATTTCGGATTTGATTTCTCAGATACAAGTACGTA

TGAGGATATCAGCGGTTTCTATCGCGAAGTTGAACTTCAAGGGTATAAAATTGACTG

GACCTACATTAGTGAGAAGGACATCGACCTGTTACAGGAAAAAGGCCAATTGTACT

TGTTTCAGATCTACAATAAGGATTTCTCAAAAAAATCGACCGGCAATGATAACTTGC

ACACCATGTACCTGAAGAACCTTTTTTCGGAGGAAAACCTTAAAGACATTGTCCTGA

AGTTGAATGGAGAAGCGGAGATTTTCTTTCGTAAGTCTTCCATTAAAAATCCAATTA

TTCATAAGAAGGGCAGCATCCTTGTGAACCGTACGTACGAGGCGGAAGAGAAGGAC CAATTCGGTAACATTCAAATCGTCCGCAAGAACATCCCTGAAAATATTTATCAGGAG

CTTTACAAGTATTTCAATGATAAGTCCGACAAGGAATTATCAGATGAGGCTGCGAAG

TTGAAAAATGTTGTTGGTCATCACGAGGCGGCGACGAATATTGTAAAGGATTATCGC

TACACTTATGACAAGTACTTTCTGCACATGCCGATCACCATTAATTTCAAGGCGAAC

AAAACAGGATTTATTAATGACCGCATCTTACAATACATTGCCAAAGAAAAGGACTT

ACACGTTATTGGCATTGATCGTGGAGAACGCAACTTAATCTACGTAAGCGTTATTGA

CACTTGCGGGAATATCGTAGAACAAAAGAGCTTCAACATCGTGAATGGTTACGATT

ACCAGATCAAGCTTAAGCAGCAGGAGGGAGCGCGCCAGATCGCGCGCAAGGAATG

GAAGGAGATTGGTAAGATCAAGGAAATCAAGGAAGGTTATCTGTCCTTGGTAATCC

ACGAAATTTCGAAAATGGTTATCAAATACAATGCTATTATTGCAATGGAGGACTTGT

CCTACGGCTTTAAAAAAGGACGCTTTAAGGTGGAGCGCCAGGTTTATCAAAAGTTTG

AAACAATGCTGATTAACAAGCTGAACTATTTGGTCTTTAAAGATATCTCCATCACCG

AAAATGGTGGGCTTTTGAAAGGCTATCAACTTACATATATCCCTGATAAGCTTAAGA

ATGTGGGTCATCAGTGCGGGTGCATTTTTTATGTTCCTGCAGCCTACACGTCCAAAA

TCGATCCTACAACTGGATTTGTTAATATCTTCAAATTTAAGGATCTTACCGTCGACG C

GAAGCGCGAATTTATCAAGAAATTCGATAGTATTCGTTATGATTCCGAAAAAAACCT

TTTCTGTTTCACCTTTGATTATAATAACTTTATCACGCAAAATACTGTCATGAGCAA A

TCGAGTTGGTCTGTGTACACTTACGGAGTACGCATCAAGCGTCGTTTTGTTAATGGG

CGCTTCAGTAACGAGTCAGACACGATTGATATCACAAAAGATATGGAGAAAACGCT

GGAGATGACAGACATCAATTGGCGCGATGGTCATGACTTACGTCAAGACATTATCG

ATTATGAAATTGTCCAGCATATCTTTGAGATCTTTCGTTTGACTGTTCAGATGCGCA A

CAGCCTGTCAGAATTGGAGGATCGTGACTATGATCGCCTTATTTCTCCCGTCTTAAA T

GAGAACAATATCTTCTACGACTCAGCCAAGGCTGGAGATGCACTGCCAAAAGACGC

CGACGCAAATGGGGCCTACTGTATTGCATTGAAGGGGTTGTACGAGATCAAACAGA

TTACAGAAAATTGGAAGGAGGACGGTAAGTTCTCTCGTGATAAGCTGAAGATTTCTA

ACAAAGACTGGTTCGATTTCATTCAGAACAAACGTTACCTG

[0062] SEQ ID NO: 25

ATGAACAACGGTACCAATAACTTTCAGAATTTCATTGGAATCAGCAGCTTACAGAAA

ACCCTGCGCAATGCACTTATCCCCACTGAGACAACCCAGCAGTTCATTGTAAAGAAC

GGGATTATTAAAGAAGATGAGCTTCGCGGGGAGAATCGTCAGATCTTAAAGGATAT

TATGGACGATTACTACCGTGGCTTCATTTCGGAGACGCTGTCGTCGATCGACGACAT

CGACTGGACATCCTTGTTTGAAAAGATGGAAATCCAACTGAAGAATGGCGATAACA

AGGACACGTTAATCAAAGAGCAGACGGAATACCGTAAAGCTATCCACAAAAAGTTC

GCTAATGACGACCGCTTTAAGAACATGTTCTCAGCAAAACTTATTAGCGATATTTTA

CCTGAATTTGTCATCCACAATAACAATTACTCCGCGAGTGAAAAAGAGGAGAAAAC CCAGGTGATTAAGCTGTTTTCCCGTTTTGCAACCAGTTTCAAGGACTATTTTAAGAAT

CGTGCTAATTGTTTCTCTGCAGACGACATTTCCTCGTCGTCCTGCCATCGCATTGTT A

ATGATAATGCTGAAATCTTTTTTTCAAACGCACTTGTGTATCGTCGCATTGTCAAAA G

CTTAAGTAATGACGATATCAATAAGATCTCAGGAGACATGAAGGACTCCCTGAAAG

AAATGTCATTGGAAGAAATTTACTCTTATGAAAAGTATGGAGAATTTATTACGCAGG

AGGGTATCAGCTTCTATAACGACATTTGTGGTAAAGTGAACAGCTTTATGAATCTTT

ATTGTCAAAAGAATAAAGAGAACAAAAATCTGTACAAGCTGCAGAAATTGCATAAA

CAAATTCTGTGCATTGCAGATACTTCGTATGAGGTTCCTTACAAATTCGAGTCGGAT

GAGGAGGTGTATCAAAGCGTAAACGGATTTTTGGATAACATTAGTAGTAAGCATATT

GTGGAACGCCTTCGCAAGATTGGTGACAACTATAACGGATACAACTTAGACAAGAT

CTATATTGTCTCGAAGTTTTACGAAAGTGTTTCCCAAAAGACTTATCGCGACTGGGA

GACAATCAACACTGCGCTGGAAATTCACTATAACAATATCTTGCCGGGGAACGGAA

AAAGTAAGGCAGATAAGGTGAAGAAAGCAGTCAAAAATGATCTGCAAAAAAGCAT

TACTGAAATTAACGAACTTGTGTCAAATTACAAATTGTGTTCGGATGACAATATTAA

AGCGGAAACGTATATCCACGAGATCTCGCACATTCTTAATAATTTCGAGGCGCAGGA

ATTAAAGTATAATCCTGAGATCCATTTGGTGGAATCAGAACTTAAAGCTAGTGAACT

GAAAAATGTCCTGGACGTTATTATGAATGCATTTCACTGGTGTTCTGTCTTTATGAC A

GAAGAACTTGTCGACAAAGACAACAACTTTTATGCGGAATTAGAAGAGATTTACGA

CGAAATTTATCCCGTTATTTCGTTATATAATTTAGTTCGTAATTACGTGACTCAGAA A

CCCTACAGCACAAAAAAGATTAAATTAAACTTTGGGATTCCGACTCTTGCTGATGGA

TGGAGCAAGTCCAAGGAGTACTCTAATAACGCCATTATCTTGATGCGTGACAACCTG

TACTACCTGGGCATTTTTAACGCTAAAAACAAACCCGACAAAAAGATCATTGAAGG

GAACACCTCGGAAAATAAGGGGGACTATAAAAAAATGATCTACAATCTGTTGCCAG

GCCCAAATAAGATGATCCCAAAGGTTTTTTTATCTTCCAAAACTGGCGTAGAAACTT

ACAAGCCGAGCGCATACATCCTTGAAGGATATAAACAAAACAAACATATCAAAAGT

TCAAAGGACTTCGATATTACGTTCTGCCATGATTTAATCGATTATTTCAAGAATTGC A

TCGCGATTCACCCAGAGTGGAAAAACTTTGGGTTTGATTTTTCAGACACCAGCACTT

ACGAGGATATTAGTGGATTCTATCGTGAGGTTGAACTGCAGGGCTATAAAATTGACT

GGACCTATATTTCTGAAAAAGATATTGATCTGCTTCAGGAGAAAGGCCAATTGTACT

TATTTCAAATCTATAACAAGGATTTCTCCAAGAAGTCCACGGGTAATGACAACTTAC

ACACAATGTATCTGAAGAATCTGTTTAGTGAGGAGAACTTGAAGGACATTGTGCTGA

AGCTTAATGGCGAGGCCGAAATCTTTTTTCGTAAGTCCTCCATTAAAAACCCTATTA

TCCATAAGAAAGGGAGTATTCTTGTCAACCGCACGTATGAGGCCGAAGAAAAGGAC

CAATTCGGAAACATCCAAATTGTCCGTAAAAATATTCCTGAGAACATTTACCAGGAG

CTTTACAAGTATTTCAACGACAAGAGTGATAAAGAACTTTCAGATGAGGCGGCGAA ACTGAAGAATGTAGTGGGGCACCACGAAGCTGCCACGAATATTGTAAAGGATTACC

GTTACACCTACGACAAGTACTTTTTGCATATGCCCATCACAATTAATTTTAAGGCCA

ATAAAACTGGTTTTATCAACGATCGTATCTTACAGTACATTGCTAAGGAAAAAGATC

TGCACGTTATCGGTATCGATCGCGGGGAACGCAATCTGATTTATGTTAGTGTGATTG

ACACGTGCGGAAATATTGTTGAGCAGAAGAGCTTTAATATCGTAAATGGATATGACT

ATCAAATTAAACTGAAGCAACAGGAAGGGGCCCGCCAGATTGCCCGCAAGGAGTGG

AAAGAAATTGGAAAGATCAAGGAGATTAAAGAAGGGTACCTTTCCCTTGTTATCCA

CGAAATCTCGAAAATGGTGATCAAGTACAATGCCATTATTGCTATGGAGGATCTGTC

ATATGGGTTTAAGAAAGGCCGCTTTAAGGTGGAACGTCAGGTTTACCAGAAGTTTGA

GACCATGCTTATCAATAAGCTGAATTATCTTGTCTTCAAAGACATCTCAATCACAGA

GAACGGCGGGCTGTTAAAAGGATATCAGCTGACCTATATCCCCGACAAACTGAAAA

ATGTCGGGCACCAATGCGGCTGTATTTTCTACGTGCCCGCTGCATACACATCTAAAA

TTGACCCAACGACTGGATTCGTAAATATTTTTAAGTTTAAGGATCTTACGGTAGATG

CAAAGCGCGAATTTATCAAGAAATTTGATAGTATCCGTTACGACAGCGAGAAAAAC

TTATTTTGTTTTACGTTCGATTATAACAACTTCATCACGCAAAATACCGTCATGTCA A

AATCTTCCTGGTCAGTCTATACGTATGGCGTCCGTATCAAGCGCCGCTTCGTCAACG

GGCGTTTTTCAAACGAGTCAGATACCATCGATATCACCAAAGATATGGAAAAAACA

TTGGAGATGACGGACATCAATTGGCGCGATGGTCATGACTTACGCCAGGACATTATT

GACTACGAAATCGTACAACATATTTTTGAGATTTTCCGTCTGACCGTGCAAATGCGC

AACTCATTATCCGAACTTGAGGATCGTGATTACGACCGCTTGATCAGTCCTGTTCTG

AACGAGAATAATATTTTTTACGACAGTGCCAAGGCGGGAGACGCACTGCCCAAGGA

CGCTGACGCTAACGGAGCTTATTGTATTGCGTTGAAGGGACTTTACGAAATCAAGCA

AATCACTGAAAACTGGAAGGAGGATGGTAAATTCTCACGCGACAAGTTGAAAATTT

CGAACAAGGACTGGTTCGATTTCATCCAAAACAAGCGTTATTTA

[0063] SEQ ID NO: 26

ATGAACAACGGGACTAATAACTTCCAGAACTTCATCGGTATTTCATCATTACAAAAA

ACGCTTCGTAACGCCTTGATCCCAACAGAAACGACCCAACAATTTATTGTAAAAAAC

GGCATCATCAAAGAAGACGAACTGCGTGGCGAAAATCGCCAAATTTTGAAGGACAT

TATGGATGACTATTATCGTGGGTTTATCTCGGAGACATTATCCTCCATCGACGACAT T

GATTGGACGAGTCTTTTTGAGAAAATGGAGATCCAGCTTAAAAATGGTGATAACAA

GGATACATTGATCAAGGAGCAAACCGAGTACCGCAAGGCCATCCATAAGAAGTTCG

CAAATGACGACCGCTTCAAAAATATGTTTAGTGCCAAATTGATCTCGGATATCCTTC

CTGAGTTCGTAATTCACAACAATAATTATAGCGCATCCGAAAAGGAGGAAAAGACT

CAAGTCATTAAGCTTTTCAGTCGCTTTGCTACCTCGTTTAAGGACTATTTCAAGAAC C

GCGCGAACTGCTTCTCAGCGGATGACATTTCTTCCTCGTCGTGTCACCGCATCGTGA ATGATAATGCGGAGATCTTCTTTAGTAATGCCTTGGTATACCGCCGCATTGTTAAAT

CCCTGTCTAACGACGATATCAATAAGATCTCAGGAGATATGAAGGATAGCCTTAAA

GAAATGTCTCTGGAAGAAATTTACTCCTATGAAAAGTACGGTGAGTTTATCACCCAA

GAGGGGATTAGCTTTTATAACGATATCTGCGGGAAGGTGAATTCGTTTATGAACCTT

TATTGTCAAAAGAATAAGGAGAATAAGAACTTATATAAGCTTCAGAAACTGCATAA

ACAAATCTTATGCATTGCCGATACTAGCTATGAAGTTCCGTATAAATTCGAGAGCGA

TGAAGAAGTTTATCAGAGCGTCAATGGGTTCTTGGATAACATTTCATCAAAACACAT

CGTGGAACGTCTGCGTAAGATTGGGGATAACTACAACGGATATAATCTTGACAAAA

TTTATATTGTATCTAAATTCTATGAGTCGGTGAGTCAAAAGACCTACCGTGATTGGG

AAACAATCAATACCGCGTTAGAAATCCACTATAACAACATTCTGCCAGGGAATGGT

AAAAGTAAAGCGGACAAAGTCAAGAAGGCTGTGAAGAACGATCTGCAAAAGAGTA

TTACAGAGATTAACGAATTAGTCTCCAATTATAAGTTATGCTCGGACGATAACATTA

AGGCGGAGACGTATATTCATGAGATTTCGCATATTCTTAACAACTTCGAGGCACAAG

AGCTTAAGTATAACCCAGAGATTCACCTTGTCGAATCGGAGCTGAAGGCATCGGAA

TTAAAAAATGTCTTAGATGTAATCATGAACGCGTTCCATTGGTGCAGTGTTTTCATG

ACTGAGGAGTTAGTTGACAAGGACAATAACTTCTACGCAGAATTAGAAGAGATCTA

TGATGAGATTTATCCAGTGATTTCGCTGTATAATCTGGTACGTAATTACGTCACTCA A

AAGCCCTACTCAACAAAAAAAATTAAGCTGAACTTCGGAATTCCGACTCTGGCCGA

CGGGTGGTCCAAGTCAAAGGAGTATTCTAATAATGCTATCATCCTGATGCGCGATAA

CTTATACTATTTGGGAATTTTCAATGCCAAAAATAAACCAGATAAAAAGATTATCGA

AGGTAATACAAGCGAGAATAAGGGTGACTATAAGAAAATGATTTACAATCTTCTTC

CAGGCCCTAACAAGATGATTCCCAAAGTTTTTTTGTCCAGTAAAACAGGGGTCGAAA

CTTACAAGCCCAGTGCCTATATCCTTGAAGGGTACAAGCAGAATAAGCACATCAAA

TCCTCGAAAGACTTTGATATTACATTTTGTCATGACTTAATCGATTATTTTAAGAAC T

GTATCGCAATCCATCCAGAATGGAAGAACTTCGGGTTTGATTTCTCTGATACTTCCA

CGTATGAGGATATTTCCGGGTTCTACCGCGAAGTAGAGCTTCAGGGCTATAAAATTG

ACTGGACATATATTTCAGAAAAAGACATCGATCTGTTACAAGAAAAAGGACAGTTG

TATCTGTTTCAAATCTATAATAAGGATTTCTCCAAAAAGTCAACTGGAAATGATAAC

TTACATACAATGTATCTGAAAAATCTTTTTAGTGAAGAGAATTTGAAGGATATCGTG

CTGAAGTTAAATGGCGAAGCAGAGATCTTCTTCCGCAAGTCCTCGATCAAGAATCCT

ATCATCCACAAGAAAGGTAGTATTCTGGTTAACCGCACGTACGAGGCCGAGGAAAA

AGACCAGTTCGGTAATATCCAGATTGTACGTAAGAATATTCCTGAAAATATTTACCA

GGAATTATACAAGTATTTTAACGACAAATCGGATAAGGAGCTTTCAGATGAGGCCG

CAAAGTTGAAGAACGTCGTAGGACACCATGAGGCCGCTACGAATATCGTCAAGGAC

TACCGCTATACGTATGACAAGTACTTCCTGCACATGCCTATTACTATCAATTTCAAA GCTAATAAAACAGGATTCATCAATGATCGTATCCTTCAGTACATTGCCAAAGAAAAA

GATCTGCACGTAATCGGAATCGACCGTGGCGAACGTAATCTGATTTACGTATCAGTT

ATCGACACATGTGGTAACATCGTGGAGCAGAAATCTTTTAACATTGTTAACGGCTAT

GATTATCAGATTAAGCTTAAACAGCAGGAGGGGGCACGCCAAATCGCTCGTAAAGA

ATGGAAGGAGATTGGAAAGATTAAAGAGATTAAAGAGGGGTACCTTTCGCTGGTTA

TTCACGAAATTTCCAAGATGGTGATTAAGTACAATGCAATCATCGCGATGGAAGATC

TTAGTTACGGATTCAAAAAGGGACGCTTCAAAGTTGAGCGTCAGGTCTACCAGAAA

TTTGAAACGATGCTGATTAACAAATTGAATTACTTGGTATTCAAAGATATCTCAATT

ACTGAAAATGGTGGCTTATTAAAGGGTTACCAGCTTACCTATATCCCGGATAAGCTG

AAGAACGTGGGCCATCAATGCGGCTGCATCTTTTACGTCCCTGCCGCATATACCTCT

AAAATTGACCCCACCACCGGATTCGTAAATATTTTTAAATTCAAGGACCTGACGGTG

GACGCCAAGCGCGAATTCATCAAAAAATTCGACTCAATCCGCTATGATTCCGAAAA

AAATCTTTTCTGCTTTACGTTCGATTATAATAACTTCATTACCCAAAACACGGTGAT G

TCAAAATCGTCCTGGAGCGTGTATACTTATGGAGTGCGTATCAAGCGCCGCTTTGTT

AATGGGCGCTTCAGTAACGAAAGCGATACCATCGACATTACCAAAGACATGGAGAA

GACGCTTGAAATGACGGATATCAATTGGCGTGACGGACACGATCTTCGTCAGGATAT

CATCGACTACGAGATTGTGCAACATATCTTTGAGATTTTCCGTTTAACTGTTCAAAT G

CGTAACTCCTTGTCCGAATTGGAAGACCGTGATTACGACCGCTTGATTTCACCAGTG

CTTAACGAGAATAACATCTTCTACGACTCCGCCAAAGCAGGCGATGCCCTGCCAAA

GGACGCTGATGCAAATGGTGCATACTGTATCGCGTTGAAGGGCTTATACGAGATTAA

GCAAATCACCGAAAATTGGAAAGAGGATGGAAAGTTCAGTCGCGATAAGCTGAAGA

TCTCTAATAAAGATTGGTTTGACTTTATCCAGAACAAACGTTATTTA

[0064] SEQ ID NO: 27

ATGAACAACGGTACCAATAATTTCCAAAATTTCATCGGAATCTCATCCTTGCAAAAA

ACCTTGCGCAATGCTTTGATCCCCACCGAAACCACGCAGCAGTTCATCGTGAAAAAC

GGCATTATCAAAGAGGATGAGTTGCGCGGGGAAAACCGTCAAATTCTTAAGGATAT

CATGGACGATTACTACCGTGGGTTTATCAGTGAGACCCTGTCAAGCATTGACGACAT

TGACTGGACCAGCTTATTTGAGAAGATGGAGATTCAATTAAAGAACGGGGACAATA

AGGACACGCTTATCAAAGAGCAGACAGAATACCGTAAAGCGATTCATAAGAAATTT

GCAAATGACGATCGCTTCAAGAACATGTTTTCAGCAAAATTAATCAGCGACATCCTT

CCCGAATTTGTGATTCATAATAACAACTATTCGGCTAGCGAAAAAGAGGAGAAAAC

TCAGGTTATTAAGCTTTTCTCGCGTTTTGCCACTTCGTTCAAAGACTATTTTAAGAA T

CGCGCAAACTGCTTTTCGGCTGATGATATTTCCAGTTCTAGCTGCCATCGTATCGTT A

ACGATAATGCTGAGATTTTCTTCTCTAATGCCCTGGTGTATCGTCGTATCGTTAAAT C

TTTGAGCAACGACGATATTAATAAGATTTCAGGCGACATGAAGGATTCTTTAAAGGA GATGTCTTTAGAAGAGATTTATTCCTATGAGAAATATGGCGAGTTTATCACCCAAGA

AGGAATTTCGTTCTACAACGACATCTGTGGCAAAGTGAACAGCTTCATGAATTTATA

CTGCCAAAAGAATAAGGAGAATAAAAATTTATATAAACTGCAGAAACTGCATAAGC

AAATTCTTTGCATTGCAGACACCTCTTATGAAGTTCCTTATAAGTTTGAATCGGACG

AGGAGGTATATCAGAGTGTGAACGGGTTCCTGGACAATATTTCATCCAAGCATATTG

TTGAACGTTTACGCAAAATTGGAGACAATTACAATGGGTATAACCTTGACAAAATTT

ACATCGTGTCGAAGTTTTACGAATCGGTAAGCCAGAAGACCTATCGTGACTGGGAA

ACTATCAATACCGCCTTAGAAATTCATTACAACAATATTCTTCCTGGTAACGGCAAA

AGCAAAGCCGATAAGGTAAAGAAGGCTGTCAAGAACGACCTGCAAAAGTCTATCAC

AGAGATCAACGAGTTAGTCTCTAACTACAAATTATGTTCCGACGACAATATTAAAGC

CGAAACCTACATCCATGAGATCTCACACATTCTTAACAATTTTGAGGCCCAGGAGCT

GAAATATAACCCAGAAATTCACCTTGTAGAGAGCGAATTAAAAGCCTCCGAGCTGA

AGAACGTTTTGGATGTAATCATGAACGCATTTCATTGGTGCAGCGTATTTATGACAG

AGGAGTTGGTCGACAAGGACAATAACTTTTACGCCGAGCTTGAAGAAATCTACGAT

GAAATTTACCCGGTAATTAGTTTATATAATTTAGTTCGCAACTACGTAACTCAGAAA

CCCTACAGTACCAAGAAGATTAAATTGAACTTTGGGATCCCGACACTTGCTGACGGT

TGGAGTAAATCAAAAGAATACTCCAATAATGCAATTATCCTGATGCGCGACAATCTT

TACTACTTGGGGATCTTTAACGCAAAGAACAAACCAGATAAGAAAATCATCGAGGG

CAACACCAGCGAGAATAAAGGCGATTACAAGAAAATGATCTATAATCTTTTGCCGG

GACCGAACAAAATGATCCCAAAGGTTTTCCTGTCGTCGAAAACGGGAGTCGAGACA

TATAAACCATCTGCGTACATCTTGGAAGGTTACAAACAGAATAAGCATATTAAGTCT

AGTAAAGACTTCGACATCACCTTTTGTCATGACCTGATTGATTATTTCAAGAACTGT

ATTGCTATCCATCCAGAATGGAAAAACTTCGGATTTGACTTCTCCGATACTAGCACC

TACGAAGACATTTCGGGTTTTTATCGCGAAGTAGAGCTTCAAGGGTACAAAATTGAT

TGGACATATATTAGCGAGAAAGACATTGATTTGCTTCAAGAGAAGGGACAGTTATA

TTTATTCCAGATCTACAACAAAGACTTCTCGAAGAAATCCACCGGTAATGATAATCT

TCACACTATGTACCTGAAGAATTTATTTTCAGAGGAAAATCTGAAGGACATTGTACT

TAAACTTAATGGAGAAGCCGAAATCTTCTTCCGCAAGAGTTCCATTAAAAATCCGAT

TATTCATAAAAAGGGAAGTATCCTTGTGAACCGCACGTATGAGGCCGAAGAGAAGG

ATCAGTTTGGGAATATTCAAATTGTCCGCAAAAACATCCCCGAGAACATCTACCAGG

AACTGTATAAATACTTTAATGATAAATCTGATAAAGAGTTATCAGACGAGGCTGCCA

AACTGAAAAACGTAGTCGGTCATCATGAGGCAGCGACCAATATTGTAAAGGACTAC

CGTTACACCTACGACAAGTATTTCCTTCACATGCCGATCACGATTAATTTTAAGGCT

AACAAGACCGGCTTTATCAATGACCGCATCTTGCAGTACATCGCGAAAGAGAAAGA

TTTACACGTCATCGGAATTGATCGTGGAGAGCGTAATCTTATCTACGTCAGCGTCAT CGACACCTGTGGAAACATTGTGGAACAAAAAAGTTTTAATATCGTAAACGGCTACG

ACTATCAAATTAAACTTAAACAGCAAGAGGGAGCTCGCCAGATCGCTCGCAAAGAG

TGGAAAGAGATTGGGAAAATTAAAGAAATTAAAGAGGGTTACCTGTCGCTGGTAAT

TCACGAAATCTCGAAAATGGTCATCAAATATAATGCAATTATCGCTATGGAGGATCT

GTCCTACGGGTTCAAGAAGGGACGTTTTAAAGTAGAGCGCCAGGTGTATCAAAAAT

TCGAAACCATGTTGATCAATAAGCTTAACTATTTGGTCTTCAAAGATATTTCGATTA C

GGAGAACGGAGGTTTGTTGAAAGGATATCAGCTGACGTATATCCCAGACAAGTTGA

AAAACGTGGGGCATCAATGTGGATGTATTTTCTATGTGCCCGCGGCCTACACGAGTA

AGATCGATCCTACCACTGGTTTCGTCAACATTTTCAAATTTAAAGATCTTACCGTGG

ATGCGAAGCGCGAATTTATTAAGAAATTTGATAGCATTCGCTATGATTCCGAAAAGA

ACCTGTTCTGTTTTACGTTCGACTATAACAATTTCATTACCCAAAACACGGTGATGA

GCAAATCCTCTTGGTCAGTTTATACATACGGTGTACGTATCAAACGCCGTTTCGTTA

ACGGACGCTTTTCCAATGAGTCTGATACAATCGATATCACGAAAGATATGGAAAAA

ACATTAGAGATGACTGATATCAACTGGCGTGACGGGCACGACCTGCGTCAAGACAT

TATTGACTACGAGATTGTGCAGCATATCTTCGAAATCTTTCGCTTAACTGTGCAAAT

GCGTAACTCGTTATCCGAGTTAGAAGACCGTGACTACGATCGCCTGATTTCACCCGT

CTTGAACGAAAATAACATCTTCTACGATTCCGCGAAGGCTGGGGACGCATTGCCCAA

GGACGCAGACGCGAATGGAGCGTACTGTATTGCGCTTAAAGGATTATATGAAATCA

AGCAGATCACCGAAAATTGGAAGGAGGACGGGAAGTTCTCACGCGACAAACTGAA

GATTTCAAATAAGGACTGGTTCGATTTCATTCAGAATAAGCGTTACCTG

[0065] SEQ ID NO: 28

TGAATAATGGTACGAACAACTTTCAGAACTTCATCGGCATCTCCAGCCTTCAAAAGA

CTTTACGCAACGCATTGATTCCCACGGAGACTACGCAACAGTTTATCGTAAAAAATG

GTATTATCAAAGAAGATGAATTACGCGGGGAGAATCGCCAGATTCTTAAGGACATT

ATGGACGATTATTACCGTGGATTCATCAGTGAGACACTGAGCTCCATTGATGACATC

GACTGGACGTCATTGTTTGAAAAGATGGAAATCCAGTTGAAAAATGGCGATAACAA

AGATACATTGATTAAAGAGCAGACAGAGTACCGCAAAGCAATTCACAAGAAATTCG

CCAATGATGATCGTTTTAAGAACATGTTTAGTGCCAAGCTTATTTCGGATATCTTAC C

CGAATTCGTGATTCACAACAACAATTATTCGGCAAGTGAGAAAGAGGAAAAGACCC

AGGTTATCAAATTGTTTTCGCGCTTCGCCACTTCGTTCAAAGATTATTTCAAGAACC G

TGCAAACTGTTTCTCCGCTGACGACATCAGTTCCAGCTCATGCCACCGTATTGTAAA

TGACAATGCGGAGATCTTTTTCAGTAATGCCTTAGTATATCGTCGCATTGTAAAGAG

CTTATCTAATGATGACATTAACAAGATCTCGGGTGATATGAAGGACTCACTTAAGGA

GATGAGTCTGGAAGAGATCTACTCCTACGAAAAATACGGGGAATTCATCACCCAGG

AGGGAATTTCATTCTACAACGATATCTGCGGCAAAGTTAACTCCTTTATGAATCTGT ACTGTCAAAAGAACAAGGAGAATAAAAACCTGTATAAATTGCAGAAACTTCATAAA

CAAATTTTGTGTATCGCAGACACGAGTTATGAAGTACCTTATAAATTCGAATCCGAC

GAAGAGGTATATCAGTCCGTAAATGGGTTCCTGGACAATATCAGTAGTAAGCACATT

GTGGAACGCTTACGCAAAATTGGAGACAATTACAACGGGTATAACCTGGACAAAAT

CTACATCGTATCCAAATTTTATGAAAGCGTGTCTCAAAAAACTTATCGTGATTGGGA

AACAATCAACACGGCTCTTGAGATCCATTACAATAACATCTTGCCGGGTAACGGCAA

ATCGAAGGCAGACAAAGTTAAAAAAGCAGTTAAGAACGACTTACAGAAAAGCATTA

CGGAGATTAACGAGTTAGTAAGTAATTACAAATTATGCTCCGACGATAATATCAAA

GCTGAAACCTACATCCATGAAATTAGCCACATTTTGAACAATTTCGAAGCGCAGGAG

CTGAAATATAACCCTGAAATCCATCTGGTAGAGTCTGAGTTGAAGGCGTCAGAACTG

AAAAACGTTCTTGACGTCATCATGAATGCCTTTCACTGGTGTAGTGTTTTTATGACT G

AGGAGCTTGTAGATAAGGACAACAACTTCTATGCTGAACTTGAAGAGATCTACGAT

GAAATCTACCCCGTAATCAGTCTGTATAATTTAGTTCGTAACTACGTCACGCAGAAA

CCCTATTCGACTAAGAAAATTAAGCTGAACTTTGGGATCCCTACTTTGGCAGACGGG

TGGAGCAAGAGTAAAGAATACAGTAATAATGCAATTATCTTGATGCGCGATAACTT

ATATTACTTAGGTATTTTCAATGCTAAGAACAAACCTGATAAGAAGATTATCGAAGG

AAATACGAGTGAGAATAAGGGAGACTACAAAAAGATGATTTACAACTTGCTGCCAG

GGCCTAATAAGATGATTCCAAAAGTTTTTCTGTCGAGCAAGACAGGGGTTGAAACTT

ATAAGCCATCCGCTTATATCCTTGAGGGGTACAAGCAGAATAAGCATATCAAGTCCT

CCAAAGATTTTGATATTACATTTTGCCACGACTTAATTGATTACTTCAAGAACTGCA T

CGCAATCCATCCCGAATGGAAGAATTTCGGCTTCGATTTCTCAGATACGTCCACGTA

TGAGGATATCTCAGGCTTTTACCGCGAAGTTGAGCTGCAAGGTTATAAAATTGATTG

GACATACATCTCCGAAAAAGACATTGATCTTTTACAGGAAAAGGGCCAATTATACTT

ATTTCAAATCTATAACAAAGATTTTAGCAAGAAGTCCACAGGTAATGATAACCTGCA

TACGATGTATTTGAAAAATCTTTTCAGTGAAGAGAATTTGAAGGATATCGTCCTGAA

GCTGAACGGTGAGGCTGAGATCTTCTTCCGCAAATCGTCTATCAAAAACCCCATCAT

TCACAAAAAGGGAAGTATCTTAGTAAACCGCACTTATGAAGCGGAGGAAAAGGATC

AGTTCGGGAACATCCAGATCGTGCGCAAGAACATTCCAGAAAACATCTATCAGGAA

CTTTACAAATATTTCAATGACAAGTCTGATAAAGAATTATCAGACGAGGCGGCGAA

ACTTAAAAATGTTGTTGGACACCACGAAGCAGCGACGAATATTGTAAAGGATTATC

GCTACACATACGATAAATACTTTTTGCACATGCCAATCACCATTAACTTTAAGGCGA

ACAAGACAGGTTTCATTAACGACCGTATTCTGCAATATATCGCAAAGGAAAAAGAC

CTGCACGTTATTGGGATCGATCGTGGCGAACGCAATTTGATCTACGTAAGCGTTATC

GACACTTGCGGAAATATCGTTGAACAAAAAAGCTTTAATATCGTCAATGGATACGAT

TACCAAATCAAGCTGAAACAACAAGAAGGGGCACGTCAGATCGCTCGTAAAGAATG GAAAGAGATTGGTAAGATCAAAGAGATTAAAGAAGGGTATCTTTCTTTAGTAATTC

ACGAGATTTCGAAAATGGTTATTAAATACAATGCGATTATTGCTATGGAAGACTTAA

GCTACGGCTTTAAGAAAGGTCGCTTCAAAGTGGAGCGCCAAGTGTATCAGAAGTTT

GAAACGATGTTGATTAACAAATTAAATTACCTGGTCTTTAAGGACATCAGTATCACA

GAAAATGGGGGGTTGCTTAAAGGGTACCAGCTTACATACATCCCTGATAAACTGAA

AAATGTCGGTCATCAGTGCGGATGTATCTTCTATGTACCAGCAGCCTATACCAGTAA

GATTGACCCTACTACTGGCTTTGTGAATATTTTTAAATTCAAGGATTTAACCGTGGA C

GCCAAGCGTGAATTTATTAAAAAATTTGATTCGATTCGCTACGACAGTGAGAAAAAC

CTTTTCTGCTTTACCTTTGACTACAACAATTTTATTACCCAGAACACCGTAATGTCA A

AGAGTTCGTGGTCTGTATATACCTACGGTGTTCGCATCAAGCGCCGCTTCGTAAACG

GGCGTTTCAGTAACGAATCTGACACCATCGACATCACTAAAGATATGGAGAAGACA

TTGGAAATGACGGACATTAATTGGCGTGATGGCCATGACTTACGTCAGGACATTATT

GATTACGAAATTGTGCAGCATATCTTCGAGATTTTCCGTTTGACAGTTCAGATGCGC

AACTCACTGAGTGAGTTAGAAGATCGCGATTACGACCGTCTGATCTCACCGGTCCTT

AATGAAAACAACATTTTCTACGACTCAGCAAAGGCGGGTGATGCCCTGCCAAAGGA

TGCGGACGCTAATGGCGCCTACTGCATCGCCCTGAAAGGATTGTATGAAATTAAGCA

GATTACAGAAAATTGGAAGGAAGATGGTAAATTTAGCCGTGATAAATTAAAAATCT

CGAACAAGGATTGGTTCGATTTTATTCAGAACAAACGTTATTTG

[0066] SEQ ID NO: 29

ATGAACAATGGAACAAATAATTTTCAAAATTTTATCGGCATCTCAAGTCTTCAAAAA

ACCCTTCGCAATGCCCTGATTCCAACTGAAACAACCCAGCAATTTATCGTCAAGAAC

GGCATCATTAAGGAAGACGAGTTACGCGGGGAGAACCGTCAAATCCTGAAAGATAT

CATGGATGACTACTATCGTGGGTTCATTTCGGAAACCTTGTCTTCAATCGACGACAT

TGACTGGACGAGTCTTTTCGAGAAAATGGAAATTCAGCTTAAAAATGGAGACAACA

AGGATACTCTGATTAAGGAACAGACAGAATATCGCAAAGCTATCCACAAAAAGTTC

GCTAATGATGATCGTTTCAAAAATATGTTTTCTGCTAAATTGATTTCCGATATCTTG C

CTGAATTTGTAATCCACAACAACAATTATTCTGCTTCCGAGAAGGAAGAGAAGACCC

AGGTCATTAAATTATTCAGCCGCTTTGCAACCAGCTTTAAAGACTACTTTAAGAATC

GCGCTAACTGCTTTTCGGCGGATGACATCTCATCATCATCATGCCACCGCATTGTGA

ACGACAATGCGGAGATCTTCTTTTCGAATGCGTTAGTTTATCGTCGCATTGTCAAAA

GTCTTAGCAATGATGACATCAACAAGATCTCAGGAGACATGAAAGATTCCTTAAAG

GAGATGTCTCTTGAGGAAATCTATTCGTATGAGAAATACGGCGAGTTCATTACCCAG

GAAGGTATTAGTTTCTACAATGATATCTGCGGCAAAGTAAATTCTTTTATGAATCTG

TATTGCCAAAAAAACAAAGAAAACAAGAATCTTTATAAGTTACAAAAGTTACATAA

GCAAATTCTGTGCATCGCTGATACATCTTATGAGGTACCCTACAAATTTGAAAGTGA TGAGGAGGTCTATCAGAGTGTCAACGGCTTCTTAGACAACATCTCTTCCAAACATAT

CGTGGAACGCCTGCGTAAAATCGGAGATAACTACAACGGATATAACTTAGATAAAA

TCTACATCGTGTCCAAGTTTTATGAAAGTGTGAGCCAAAAAACATATCGTGACTGGG

AAACCATTAACACCGCATTGGAAATTCACTATAACAACATTTTGCCAGGCAACGGG

AAAAGTAAGGCGGACAAAGTTAAGAAAGCAGTTAAAAATGACCTGCAAAAAAGCA

TCACTGAAATTAACGAATTGGTATCGAATTACAAATTATGTAGCGACGATAATATCA

AAGCAGAAACTTACATTCACGAGATTAGTCACATTTTAAATAACTTCGAGGCCCAGG

AATTGAAATACAATCCCGAAATTCATTTGGTTGAATCAGAACTGAAAGCATCAGAGT

TGAAAAATGTGTTAGATGTCATTATGAATGCGTTTCATTGGTGCTCTGTGTTCATGA C

CGAGGAACTGGTTGATAAAGATAACAACTTTTACGCTGAATTGGAGGAGATTTACG

ATGAGATTTACCCGGTCATTTCGCTTTATAACTTAGTGCGCAATTATGTGACGCAGA

AACCATATTCCACGAAGAAAATCAAACTTAATTTTGGCATCCCTACTCTGGCTGATG

GTTGGTCGAAATCGAAAGAGTACAGCAACAACGCGATCATTCTTATGCGTGACAAT

CTTTACTATTTGGGCATTTTTAATGCCAAGAATAAGCCAGATAAGAAAATCATTGAG

GGGAATACTTCCGAGAATAAGGGGGATTACAAAAAGATGATCTATAACTTGCTGCC

CGGCCCCAACAAAATGATTCCTAAGGTTTTCTTGTCAAGCAAGACGGGCGTCGAAAC

ATATAAGCCGTCAGCTTATATTCTGGAAGGCTATAAACAGAATAAGCACATCAAGTC

TTCCAAGGACTTTGACATCACTTTTTGCCACGATTTGATCGACTACTTTAAGAACTG T

ATTGCGATTCATCCGGAATGGAAGAACTTCGGTTTCGACTTTTCCGATACCTCAACA

TACGAGGATATCAGCGGCTTCTACCGTGAAGTCGAGCTTCAAGGCTACAAGATCGAT

TGGACATATATTTCAGAGAAGGACATTGATTTGTTACAAGAGAAAGGTCAACTTTAC

TTATTTCAGATCTATAACAAAGACTTTTCGAAGAAATCGACAGGAAACGATAACTTA

CACACTATGTATTTAAAAAATCTGTTTTCGGAGGAAAACCTGAAAGATATTGTGCTG

AAACTTAACGGCGAGGCAGAGATCTTTTTCCGTAAAAGCTCAATCAAGAATCCTATC

ATCCATAAAAAAGGTAGTATTCTTGTCAACCGCACATATGAAGCGGAGGAGAAGGA

CCAATTCGGAAACATCCAAATTGTCCGTAAGAATATTCCGGAGAACATTTACCAAGA

GTTGTATAAATACTTTAACGATAAGTCAGATAAGGAACTTAGCGATGAGGCGGCGA

AGCTTAAAAACGTAGTTGGGCATCATGAAGCTGCTACCAACATTGTAAAAGATTACC

GTTACACCTATGACAAGTATTTCTTGCACATGCCCATTACGATCAATTTCAAAGCAA

ATAAGACAGGCTTTATCAATGATCGCATCCTGCAGTACATTGCTAAAGAGAAGGATT

TGCATGTTATCGGTATTGATCGCGGAGAGCGCAATTTGATCTACGTCTCCGTAATCG

ACACTTGCGGTAACATTGTTGAGCAGAAGTCGTTCAACATCGTTAATGGTTATGATT

ACCAAATCAAGCTGAAGCAGCAAGAGGGTGCCCGCCAGATCGCGCGTAAGGAATGG

AAAGAAATCGGGAAAATTAAAGAGATCAAAGAAGGCTATTTGTCTCTGGTAATTCA

CGAAATCAGCAAGATGGTGATCAAGTATAACGCGATCATTGCGATGGAGGATCTTT CTTATGGCTTCAAGAAAGGGCGCTTTAAAGTCGAACGCCAGGTCTACCAGAAATTTG

AGACAATGCTTATCAACAAGCTTAACTATCTTGTATTTAAGGATATTTCCATCACTG

AGAACGGAGGACTTTTAAAGGGGTACCAACTGACGTACATTCCTGATAAGCTGAAG

AACGTTGGTCATCAATGCGGATGCATCTTCTATGTGCCAGCGGCTTACACCTCCAAA

ATCGATCCCACTACAGGCTTTGTCAATATCTTCAAATTCAAGGATTTGACCGTTGAC

GCGAAGCGCGAGTTTATCAAGAAGTTTGATAGCATTCGCTACGACAGCGAAAAAAA

TTTATTTTGTTTTACTTTCGACTACAATAACTTTATTACTCAGAACACTGTCATGTC A

AAGAGTTCGTGGAGTGTCTACACGTACGGAGTACGTATTAAGCGCCGTTTCGTCAAC

GGACGCTTCTCAAACGAAAGCGACACGATCGACATCACCAAAGACATGGAAAAAAC

TCTTGAGATGACGGATATCAATTGGCGCGACGGCCATGACCTGCGTCAGGATATCAT

TGATTACGAGATCGTTCAGCACATCTTCGAAATCTTCCGCCTTACCGTCCAGATGCG

CAACAGTTTAAGCGAGCTTGAAGACCGCGACTACGATCGTTTGATTAGCCCCGTTCT

GAACGAGAATAATATTTTCTACGACAGCGCAAAGGCCGGTGATGCTTTGCCAAAGG

ACGCAGACGCGAATGGAGCCTACTGCATCGCCCTGAAGGGCTTATATGAGATTAAG

CAAATTACCGAAAATTGGAAGGAAGATGGTAAGTTCTCCCGTGATAAGCTTAAAAT

TAGCAATAAGGATTGGTTCGACTTCATCCAGAACAAACGTTACCTG

[0067] SEQ ID NO: 30

ATGAACAACGGAACAAACAATTTCCAAAACTTCATCGGTATCTCTTCGTTGCAGAAG

ACTCTGCGTAATGCTTTGATCCCGACGGAGACAACCCAACAATTTATCGTCAAAAAC

GGTATTATTAAGGAGGACGAGTTACGTGGAGAAAATCGTCAAATCCTTAAGGACAT

CATGGACGATTATTATCGCGGGTTTATTTCTGAAACCCTGAGCAGTATCGATGATAT

CGACTGGACCTCACTTTTTGAGAAAATGGAGATCCAGTTGAAGAACGGTGATAACA

AAGACACTCTGATCAAAGAGCAAACTGAATACCGCAAGGCAATTCACAAAAAGTTC

GCCAACGACGACCGTTTCAAGAATATGTTCTCAGCTAAGTTAATCAGCGACATTTTG

CCAGAGTTCGTTATCCACAACAATAATTATAGTGCTTCAGAGAAGGAGGAAAAAAC

CCAAGTGATTAAACTTTTTTCGCGCTTTGCAACCTCATTCAAGGACTACTTCAAGAA T

CGCGCGAATTGCTTCAGTGCGGACGACATTTCTTCTTCAAGTTGCCATCGTATCGTT A

ACGATAACGCGGAAATTTTCTTCTCTAATGCTTTGGTGTATCGCCGCATTGTAAAAT C

GCTTAGTAACGATGACATTAATAAGATCTCAGGTGATATGAAAGATTCATTGAAGG

AAATGAGCTTGGAAGAGATTTACAGTTACGAAAAATATGGAGAATTTATTACTCAG

GAAGGCATCTCATTCTATAACGATATCTGCGGGAAGGTAAATTCGTTTATGAACTTA

TATTGCCAGAAAAATAAAGAGAATAAAAATTTGTATAAGCTTCAGAAGTTGCACAA

ACAGATCCTGTGCATTGCAGACACCTCGTATGAGGTTCCGTATAAATTTGAGTCCGA

TGAAGAAGTGTATCAGTCTGTGAATGGTTTCTTAGATAATATCTCTTCCAAGCATAT T

GTCGAACGCCTGCGCAAAATTGGTGATAACTATAACGGATACAATCTGGATAAAAT TTACATCGTTTCTAAATTTTACGAGTCAGTCTCGCAGAAGACCTACCGCGACTGGGA

AACAATTAACACGGCATTGGAGATTCACTACAATAATATCTTGCCTGGTAACGGTAA

GTCTAAGGCAGATAAGGTAAAAAAAGCTGTGAAAAACGACCTTCAGAAAAGCATCA

CGGAGATTAATGAGCTGGTGAGTAATTACAAATTATGTTCAGACGATAATATTAAAG

CTGAAACGTATATCCATGAAATCTCGCATATCTTGAACAACTTCGAGGCCCAAGAAC

TTAAATATAACCCCGAAATCCATTTAGTCGAGTCTGAATTGAAAGCGTCGGAATTAA

AAAACGTCTTAGACGTCATTATGAACGCGTTTCACTGGTGTTCAGTTTTCATGACCG

AAGAGCTGGTCGACAAAGACAACAACTTCTATGCGGAATTGGAGGAAATCTATGAT

GAAATCTACCCTGTTATTTCACTGTATAACCTTGTGCGCAACTATGTCACTCAGAAG

CCGTATTCGACCAAAAAAATTAAATTGAATTTCGGTATCCCTACTCTTGCAGACGGA

TGGAGTAAAAGCAAGGAATACAGTAATAACGCCATTATTCTTATGCGCGACAATTTA

TACTACCTGGGCATCTTTAACGCAAAGAATAAGCCGGATAAGAAGATTATTGAGGG

TAACACCAGTGAGAACAAGGGCGACTATAAGAAGATGATCTATAACTTATTGCCAG

GTCCAAATAAAATGATCCCAAAAGTATTCTTATCATCAAAGACGGGAGTTGAAACCT

ATAAGCCTAGTGCCTATATTCTTGAGGGATATAAACAGAACAAGCACATTAAGTCGT

CTAAGGATTTTGACATTACGTTCTGCCATGACTTAATCGACTATTTTAAAAACTGTA T

TGCGATTCACCCCGAATGGAAGAATTTTGGATTCGATTTTTCGGATACCTCGACCTA

TGAAGATATTTCGGGATTTTATCGTGAAGTGGAGTTGCAAGGCTATAAAATCGATTG

GACCTATATCTCAGAAAAAGACATTGATTTATTACAGGAAAAGGGACAACTGTACC

TTTTCCAAATTTATAACAAGGACTTTTCTAAAAAGTCCACAGGAAATGATAACCTTC

ACACCATGTACCTGAAGAACCTTTTCTCAGAGGAAAACCTGAAGGACATTGTCCTTA

AGTTAAATGGAGAAGCGGAGATCTTTTTCCGTAAATCTAGTATCAAGAATCCGATTA

TCCATAAAAAAGGTTCGATTTTGGTAAATCGCACCTATGAAGCGGAAGAGAAAGAT

CAATTTGGTAACATCCAGATCGTGCGCAAGAATATCCCGGAGAACATTTACCAAGA

GCTGTATAAGTACTTCAATGATAAGTCTGATAAGGAACTGTCAGATGAAGCTGCGA

AATTGAAGAACGTGGTTGGGCATCATGAAGCCGCTACCAATATCGTCAAGGATTAC

CGTTATACCTATGACAAATATTTCTTACACATGCCGATTACGATCAATTTTAAGGCA

AACAAGACAGGATTCATCAACGACCGTATCTTGCAGTATATTGCCAAAGAGAAGGA

TCTGCATGTGATCGGTATTGACCGCGGGGAGCGCAATTTAATCTATGTATCGGTGAT

CGATACTTGTGGTAACATCGTAGAACAAAAGAGCTTTAACATCGTGAATGGTTACGA

CTATCAGATCAAGCTGAAACAACAGGAAGGAGCCCGCCAGATCGCTCGCAAGGAAT

GGAAAGAAATCGGGAAAATTAAGGAAATCAAGGAAGGCTACCTTTCATTGGTCATT

CACGAAATTTCGAAAATGGTAATTAAGTACAACGCGATCATCGCCATGGAGGACCT

TTCGTACGGATTTAAGAAGGGTCGTTTCAAAGTTGAGCGCCAGGTATACCAAAAATT

CGAGACTATGCTTATCAACAAACTTAACTACTTGGTCTTTAAGGACATTTCTATTAC C GAAAACGGCGGCTTACTTAAAGGCTATCAATTGACATATATTCCCGACAAACTGAA

GAATGTTGGACATCAATGCGGGTGTATTTTCTATGTGCCGGCAGCTTACACTAGTAA

GATCGACCCTACAACCGGGTTCGTAAACATTTTTAAATTCAAAGACTTAACAGTCGA

TGCGAAGCGTGAATTTATTAAGAAGTTTGATAGTATCCGCTATGACAGTGAAAAGA

ACTTGTTTTGCTTTACGTTCGACTACAATAACTTTATTACACAGAACACGGTCATGT C

TAAATCATCATGGTCGGTTTACACATATGGGGTGCGCATCAAGCGTCGCTTTGTAAA

TGGCCGTTTTAGTAATGAGAGCGACACAATCGACATCACAAAGGATATGGAGAAAA

CTCTTGAGATGACAGACATCAATTGGCGTGACGGTCATGACTTACGCCAAGATATCA

TCGACTACGAAATCGTACAGCATATTTTTGAGATTTTTCGTCTTACTGTGCAAATGC G

TAATTCTTTATCCGAACTGGAAGATCGTGATTACGACCGCTTGATTAGTCCCGTCTT A

AATGAGAACAATATTTTCTATGATTCTGCGAAAGCCGGAGATGCACTGCCCAAAGA

CGCTGATGCCAATGGCGCGTATTGCATTGCATTAAAAGGATTATATGAGATTAAACA

GATTACCGAAAATTGGAAAGAGGACGGTAAATTCTCACGCGATAAATTGAAGATTT

CTAACAAGGACTGGTTCGACTTTATCCAAAATAAACGTTATCTT

[0068] SEQ ID NO: 31

ATGAATAACGGTACCAACAACTTTCAGAATTTCATTGGCATTAGCTCGCTTCAAAAA

ACTTTACGCAATGCTCTTATTCCGACTGAGACGACACAACAGTTTATCGTTAAGAAT

GGCATCATCAAAGAAGATGAATTACGCGGAGAAAACCGCCAGATCCTGAAAGACAT

TATGGACGATTATTACCGTGGGTTCATCTCCGAGACGTTGTCATCGATCGATGACAT

CGACTGGACGTCACTTTTTGAAAAAATGGAGATCCAGTTAAAGAACGGTGACAATA

AGGATACATTGATCAAAGAACAGACCGAGTACCGTAAAGCGATTCATAAAAAGTTT

GCGAACGATGATCGCTTCAAGAATATGTTTTCTGCGAAATTAATTTCCGACATTTTA

CCTGAATTTGTTATTCATAATAACAACTACTCGGCGTCTGAGAAAGAGGAGAAAACC

CAAGTGATTAAACTTTTTTCACGTTTCGCAACGTCGTTCAAAGACTATTTTAAAAAT C

GTGCTAATTGCTTTAGCGCGGATGACATCAGCTCTAGTTCATGTCATCGCATTGTCA

ACGATAATGCTGAGATCTTTTTCAGTAATGCGTTAGTGTACCGTCGTATTGTGAAGT

CCTTATCTAATGATGATATCAATAAGATCAGCGGGGATATGAAGGACTCACTTAAGG

AGATGAGCTTGGAGGAAATCTATTCCTATGAGAAGTATGGTGAGTTTATTACGCAAG

AAGGAATTAGCTTTTACAACGATATCTGTGGAAAGGTGAATTCGTTTATGAATTTGT

ATTGCCAGAAAAATAAGGAGAACAAGAACCTTTATAAATTGCAAAAGTTACACAAG

CAAATCCTGTGCATTGCAGATACTTCCTACGAGGTGCCTTACAAGTTTGAATCCGAC

GAAGAGGTCTACCAATCTGTAAACGGTTTCTTAGATAATATTAGTTCCAAGCATATT

GTGGAGCGCCTTCGTAAAATTGGCGATAATTACAACGGTTACAATTTAGACAAAATT

TACATTGTCAGTAAATTCTACGAGTCCGTATCTCAAAAGACGTATCGTGATTGGGAG

ACTATCAATACGGCCCTGGAGATCCACTACAACAATATCTTGCCCGGTAATGGTAAG TCGAAGGCCGATAAAGTTAAGAAAGCGGTGAAAAATGACTTACAGAAGTCAATCAC

CGAAATTAACGAATTGGTGTCCAATTATAAATTGTGTTCAGATGATAATATCAAAGC

CGAGACCTACATTCATGAGATTTCCCATATCTTAAATAATTTCGAGGCGCAAGAGCT

TAAGTATAACCCAGAAATCCACCTGGTAGAATCTGAGTTGAAGGCGTCAGAGTTAA

AAAATGTTTTAGATGTCATTATGAACGCGTTTCACTGGTGCTCCGTATTTATGACGG

AGGAATTAGTAGATAAAGACAACAATTTCTATGCCGAACTTGAGGAAATCTATGAT

GAGATCTATCCCGTCATTAGCCTGTATAACTTGGTCCGCAACTATGTTACCCAAAAA

CCGTACAGTACCAAGAAGATTAAGCTGAATTTCGGCATTCCTACACTGGCTGATGGT

TGGAGTAAATCGAAGGAATATTCGAATAACGCGATTATCTTGATGCGCGACAACTTA

TACTATTTGGGGATCTTTAACGCCAAAAACAAACCGGATAAGAAGATTATTGAGGG

AAACACATCAGAGAACAAAGGCGACTACAAAAAAATGATTTACAACTTGTTACCGG

GGCCTAACAAAATGATCCCGAAGGTGTTCTTATCCAGTAAAACAGGCGTTGAGACCT

ACAAACCTTCCGCATACATCCTGGAAGGGTATAAGCAGAACAAGCACATTAAGTCC

AGCAAGGATTTCGATATTACCTTCTGTCATGATTTAATTGACTATTTCAAGAACTGT A

TTGCAATCCACCCCGAGTGGAAGAACTTCGGATTCGACTTCTCAGATACGAGCACAT

ATGAGGACATCTCGGGGTTCTATCGTGAAGTAGAACTGCAGGGATATAAAATTGATT

GGACATATATTTCCGAAAAAGACATCGACCTTTTACAAGAGAAGGGTCAACTTTACT

TGTTCCAAATTTACAATAAAGACTTCTCAAAAAAAAGCACGGGTAACGATAATTTAC

ACACTATGTATTTAAAGAACCTTTTCTCGGAAGAGAATTTAAAGGATATCGTATTGA

AGTTGAATGGAGAAGCGGAGATCTTCTTCCGTAAGTCCAGTATTAAAAACCCTATTA

TTCACAAGAAGGGATCGATTTTAGTTAACCGCACATACGAGGCCGAAGAGAAGGAC

CAATTTGGGAACATTCAAATTGTCCGCAAAAACATCCCTGAGAACATTTATCAAGAG

CTTTATAAGTACTTTAACGATAAGTCCGATAAGGAATTGTCAGATGAGGCGGCAAA

GTTGAAGAATGTCGTGGGGCATCATGAAGCTGCCACCAACATTGTGAAGGACTACC

GCTACACTTACGACAAATACTTCCTGCACATGCCCATTACGATCAATTTTAAGGCCA

ATAAGACAGGCTTTATTAACGACCGTATTCTTCAATATATCGCTAAGGAGAAGGACC

TTCATGTGATTGGGATCGACCGCGGAGAACGTAATTTAATTTATGTGTCCGTCATCG

ATACGTGTGGAAATATCGTGGAACAGAAATCATTCAATATCGTGAATGGCTATGATT

ACCAGATCAAATTAAAACAGCAGGAGGGCGCTCGCCAAATTGCGCGTAAGGAATGG

AAAGAGATCGGAAAAATCAAAGAAATCAAAGAAGGATATTTGTCATTGGTGATCCA

TGAGATTTCAAAAATGGTAATTAAATATAATGCAATTATCGCAATGGAAGACCTGTC

CTATGGTTTTAAGAAGGGTCGTTTCAAGGTAGAACGCCAAGTGTATCAAAAGTTCGA

GACGATGCTGATCAATAAGCTGAATTATCTTGTGTTTAAGGACATTAGCATCACGGA

AAATGGAGGGCTGTTGAAAGGCTATCAACTGACGTATATCCCTGACAAGCTGAAAA

ATGTTGGCCATCAGTGCGGGTGCATTTTCTACGTCCCCGCGGCGTATACAAGCAAGA TCGATCCTACTACGGGATTCGTAAATATTTTTAAATTCAAAGACTTAACCGTGGACG

CCAAGCGCGAATTCATTAAGAAGTTTGATAGCATTCGCTACGATTCAGAAAAAAATC

TTTTCTGTTTTACGTTCGATTACAACAATTTTATCACCCAGAACACAGTGATGAGCA A

GTCATCCTGGTCTGTCTATACCTACGGTGTCCGTATCAAACGCCGCTTCGTCAACGG

ACGCTTCTCTAATGAATCTGATACCATTGACATCACCAAGGACATGGAAAAGACACT

TGAGATGACAGATATTAACTGGCGTGACGGACATGACCTGCGTCAGGACATCATCG

ATTATGAGATTGTTCAGCATATCTTCGAGATCTTCCGCCTGACAGTACAAATGCGCA

ATTCACTGTCAGAACTTGAAGACCGCGACTATGACCGCCTGATCTCTCCAGTATTAA

ATGAGAACAATATCTTTTATGACAGTGCTAAGGCCGGCGATGCCCTTCCGAAAGATG

CTGATGCTAACGGAGCTTATTGTATTGCATTAAAGGGTCTTTATGAGATCAAGCAAA

TTACCGAGAATTGGAAGGAGGATGGCAAATTCTCGCGCGACAAACTGAAAATCAGT

AACAAGGACTGGTTCGATTTTATTCAGAATAAACGTTACCTG

[0069] SEQ ID NO: 32

ATGAATAACGGAACGAACAACTTCCAGAACTTCATCGGCATCAGTTCTTTACAAAAA

ACCCTGCGTAACGCCCTTATTCCGACTGAGACAACACAACAGTTCATCGTTAAAAAC

GGAATTATCAAAGAGGACGAGTTGCGCGGCGAGAATCGCCAAATTTTGAAAGATAT

TATGGACGACTATTATCGTGGTTTTATTTCAGAAACACTGAGTTCGATTGACGATAT

CGATTGGACGAGCCTGTTTGAGAAAATGGAAATCCAGTTGAAAAATGGCGATAATA

AAGACACTTTAATCAAAGAACAAACCGAGTATCGTAAAGCGATCCATAAAAAGTTC

GCTAATGACGATCGTTTTAAGAATATGTTCAGTGCGAAACTGATTTCAGACATTTTG

CCCGAGTTCGTGATCCATAATAACAACTATTCCGCCTCGGAAAAGGAAGAAAAAAC

CCAGGTGATTAAGCTGTTCAGTCGCTTCGCAACATCTTTCAAGGATTATTTCAAGAA

TCGCGCGAATTGCTTCAGTGCGGACGATATTTCTAGTTCAAGCTGCCATCGTATCGT T

AATGATAACGCGGAGATTTTTTTTAGCAATGCTCTGGTGTACCGCCGCATTGTTAAG

TCACTGTCCAACGATGATATTAACAAGATCTCAGGAGACATGAAAGACTCGCTTAA

AGAGATGAGTCTGGAAGAGATCTATTCTTATGAGAAGTATGGCGAGTTTATTACCCA

AGAAGGAATCTCATTCTACAATGATATTTGTGGAAAGGTGAACAGCTTTATGAATCT

TTACTGCCAAAAAAACAAGGAGAATAAGAATCTTTACAAACTTCAGAAGTTACATA

AACAGATTTTGTGTATTGCGGATACGTCTTATGAAGTCCCCTACAAATTTGAATCGG

ATGAAGAGGTATACCAAAGTGTGAACGGATTCTTGGACAATATTTCTTCTAAACATA

TTGTTGAACGCTTACGTAAGATCGGGGATAACTACAATGGCTACAATCTTGACAAAA

TCTACATTGTTAGCAAATTCTACGAGAGTGTCAGCCAAAAGACGTACCGCGATTGGG

AAACAATTAATACTGCGCTTGAGATTCACTATAATAACATTTTACCAGGCAACGGCA

AGTCCAAGGCGGATAAAGTTAAAAAAGCTGTTAAAAACGATTTGCAAAAATCTATC

ACAGAAATTAACGAGTTAGTTAGTAACTACAAACTGTGCTCCGATGACAACATTAA GGCTGAGACGTATATCCATGAGATCTCTCACATCTTAAACAATTTTGAAGCTCAAGA

ACTTAAGTACAATCCGGAAATCCACCTGGTGGAATCCGAGCTGAAGGCTAGCGAAC

TGAAGAACGTATTGGACGTGATCATGAACGCGTTCCACTGGTGTTCTGTCTTTATGA

CGGAAGAGCTTGTCGACAAAGATAATAACTTTTACGCGGAACTTGAGGAAATTTAC

GATGAGATTTACCCAGTTATTTCATTGTATAACCTTGTCCGTAATTACGTGACCCAA A

AGCCTTATAGTACGAAAAAAATCAAATTAAATTTTGGAATCCCAACACTGGCTGACG

GTTGGAGCAAATCTAAGGAGTATTCTAATAACGCAATCATCTTAATGCGTGACAACC

TGTATTATTTGGGTATCTTCAATGCCAAAAATAAGCCTGACAAAAAGATTATCGAAG

GAAATACTTCGGAGAATAAGGGGGATTACAAAAAAATGATTTACAATTTGCTGCCC

GGGCCGAACAAGATGATCCCCAAAGTGTTCTTATCCTCGAAGACTGGTGTAGAAAC

ATACAAGCCAAGCGCATACATTCTGGAGGGTTACAAGCAAAACAAACACATCAAAT

CTTCAAAAGACTTTGACATTACATTTTGCCATGATCTTATTGACTACTTCAAAAACT G

CATTGCTATTCACCCCGAGTGGAAGAACTTTGGGTTTGACTTCAGCGACACGTCTAC

GTATGAGGACATCTCCGGGTTCTACCGTGAAGTTGAGTTACAAGGGTATAAGATTGA

CTGGACGTATATTTCAGAGAAAGATATCGATCTTTTGCAGGAAAAGGGCCAGTTATA

TTTATTCCAGATTTACAACAAGGACTTTAGTAAGAAGTCAACAGGAAATGACAACTT

GCATACGATGTATTTGAAAAATCTTTTTTCTGAGGAAAATCTTAAGGACATCGTACT

GAAATTGAATGGCGAGGCTGAAATCTTCTTCCGTAAATCCTCCATTAAGAATCCCAT

TATCCACAAAAAGGGGTCTATCCTGGTGAATCGTACCTACGAGGCAGAGGAGAAGG

ATCAATTCGGAAATATTCAGATTGTTCGTAAGAACATCCCCGAGAACATTTATCAAG

AATTGTATAAGTACTTTAATGACAAATCTGACAAAGAGTTATCCGACGAAGCTGCGA

AACTGAAAAACGTTGTTGGTCACCACGAGGCCGCCACTAATATCGTAAAAGACTAC

CGTTATACCTATGACAAGTACTTTTTGCACATGCCGATCACTATCAACTTCAAGGCG

AATAAGACGGGCTTCATTAACGATCGTATCCTGCAATACATCGCCAAGGAGAAGGA

CCTTCACGTCATTGGGATTGACCGTGGTGAGCGTAACCTGATTTATGTAAGCGTCAT

TGATACCTGCGGTAATATCGTCGAACAGAAAAGTTTCAACATTGTAAATGGATATGA

CTATCAGATCAAACTTAAGCAGCAGGAGGGTGCACGCCAGATTGCCCGCAAGGAAT

GGAAGGAGATTGGGAAGATTAAGGAAATTAAAGAAGGTTACTTATCACTGGTTATT

CACGAGATCAGTAAAATGGTAATCAAATATAACGCGATCATTGCCATGGAGGATCT

GAGCTATGGCTTTAAAAAGGGCCGTTTCAAAGTCGAGCGCCAGGTATATCAAAAGT

TTGAAACAATGCTGATTAACAAATTAAACTATCTGGTTTTCAAAGATATTTCGATCA

CTGAAAATGGCGGGCTGTTGAAGGGATACCAACTTACATACATCCCTGACAAACTG

AAAAATGTCGGTCACCAATGTGGATGTATCTTTTATGTACCAGCAGCGTATACGAGC

AAAATCGATCCAACTACGGGTTTTGTGAACATCTTTAAGTTCAAGGATTTGACAGTA

GATGCCAAACGCGAGTTCATTAAAAAATTTGATTCAATTCGCTACGATTCAGAGAAA AATCTTTTTTGTTTCACGTTCGATTACAATAATTTCATTACGCAGAACACAGTAATGT

CAAAGTCAAGCTGGTCGGTCTACACGTATGGAGTCCGTATTAAACGTCGTTTTGTAA

ACGGCCGTTTCTCAAATGAATCAGATACAATTGATATTACGAAGGATATGGAGAAG

ACATTAGAGATGACTGACATTAACTGGCGCGACGGACATGATCTTCGTCAGGACATT

ATTGATTATGAGATTGTACAGCATATCTTTGAGATCTTCCGCCTGACCGTTCAGATG C

GCAATTCGTTGTCCGAGTTAGAAGACCGCGATTACGACCGTTTAATCAGTCCCGTCT

TAAACGAAAATAACATCTTCTACGATTCAGCCAAGGCAGGCGATGCCTTGCCAAAG

GATGCTGACGCAAATGGCGCATACTGTATTGCGTTGAAAGGCCTTTATGAAATCAAG

CAAATTACCGAAAACTGGAAAGAAGACGGAAAATTCTCCCGTGATAAGTTGAAAAT

CTCTAATAAGGATTGGTTCGATTTCATCCAAAATAAACGCTATTTG

[0070] SEQ ID NO: 33

ATGAACAACGGAACTAATAATTTCCAAAATTTTATAGGCATCTCTTCTTTACAGAAG

ACTCTTCGTAACGCCCTAATCCCGACTGAGACCACACAACAATTCATAGTGAAAAAT

GGGATCATTAAAGAAGACGAGCTGCGTGGGGAGAACAGGCAGATCCTAAAAGACA

TAATGGACGATTATTATAGAGGGTTCATCTCAGAGACATTATCTAGCATCGACGACA

TTGACTGGACCTCCCTGTTTGAAAAAATGGAAATCCAGCTGAAGAATGGTGACAAT

AAAGACACATTAATAAAAGAACAAACAGAGTACAGGAAAGCCATCCACAAGAAGT

TCGCAAACGATGACAGATTCAAAAATATGTTCAGTGCGAAGCTAATATCCGACATCT

TACCAGAGTTTGTAATACACAATAACAATTACAGCGCGAGCGAAAAGGAAGAGAAA

ACGCAAGTAATTAAGCTTTTTAGTAGGTTCGCTACCTCTTTCAAAGATTACTTCAAA

AATCGTGCTAACTGCTTCTCAGCCGACGACATATCTTCAAGTTCCTGTCACCGTATC G

TGAATGATAACGCTGAGATATTCTTCTCAAACGCCCTTGTATACCGTAGGATCGTAA

AGTCCTTATCTAACGATGATATAAACAAGATCAGTGGAGACATGAAAGACAGCCTT

AAAGAGATGTCTCTAGAAGAAATTTACTCCTATGAAAAGTATGGGGAGTTTATAAC

ACAGGAGGGGATCAGCTTCTACAACGACATCTGCGGAAAGGTGAACAGTTTCATGA

ATCTTTACTGCCAGAAGAATAAAGAGAACAAAAATCTTTATAAGCTTCAAAAGTTGC

ACAAACAAATACTGTGCATTGCCGATACATCATATGAGGTCCCCTATAAGTTCGAAT

CTGATGAGGAAGTTTATCAATCTGTTAACGGCTTTCTAGACAATATCAGCTCAAAAC

ACATCGTAGAAAGACTGAGGAAAATAGGTGATAATTATAATGGATACAACTTGGAT

AAAATATATATAGTCTCTAAATTTTACGAGTCAGTATCCCAGAAAACGTATAGGGAT

TGGGAGACCATCAACACGGCGTTAGAGATTCATTACAATAACATCTTACCGGGAAA

CGGAAAAAGTAAGGCGGACAAAGTAAAGAAAGCCGTTAAAAATGACTTACAAAAG

AGTATAACAGAAATAAACGAACTAGTAAGCAACTACAAGCTTTGTTCCGATGATAA

TATCAAGGCCGAGACATATATCCATGAGATCTCCCACATTCTAAACAATTTCGAAGC

GCAAGAACTTAAATATAATCCCGAAATCCACCTGGTGGAAAGTGAACTAAAGGCTA GTGAGTTAAAGAACGTTCTTGATGTTATCATGAACGCCTTCCATTGGTGCTCTGTTTT

TATGACCGAGGAGTTGGTTGATAAAGATAATAATTTCTACGCTGAATTAGAGGAGAT

ATACGACGAAATCTACCCAGTGATTTCACTATACAACTTGGTCAGGAACTATGTTAC

ACAAAAGCCGTACAGCACTAAGAAAATTAAGCTAAATTTCGGTATCCCCACGTTAG

CCGACGGGTGGAGCAAGTCCAAAGAATATTCCAACAATGCGATTATTTTAATGCGTG

ACAATCTTTATTACCTTGGCATCTTCAATGCCAAAAACAAACCTGACAAAAAGATTA

TAGAAGGTAATACGTCCGAGAACAAAGGCGATTACAAGAAGATGATTTATAACCTA

CTGCCCGGACCAAACAAAATGATCCCCAAAGTTTTTCTTAGTTCTAAAACCGGCGTA

GAGACGTATAAACCTTCTGCCTATATCTTAGAGGGATATAAGCAGAACAAACATATC

AAATCTTCCAAGGACTTTGATATTACATTCTGCCACGATTTAATTGACTACTTCAAA A

ATTGCATAGCGATACATCCGGAGTGGAAGAACTTTGGCTTCGACTTCAGTGATACAT

CCACCTATGAGGATATATCAGGCTTCTATCGTGAGGTCGAATTGCAAGGGTACAAAA

TCGATTGGACGTATATATCCGAGAAAGACATAGACCTTCTTCAAGAAAAGGGGCAG

TTATATTTATTCCAAATATACAACAAGGACTTCAGTAAGAAGTCAACAGGTAATGAC

AACTTACACACCATGTACTTGAAAAATTTATTTTCTGAAGAAAACCTAAAGGACATT

GTACTAAAACTGAACGGGGAGGCAGAAATTTTTTTTAGAAAGAGCAGCATAAAAAA

CCCAATAATTCATAAGAAAGGAAGCATTTTAGTTAATAGGACGTACGAGGCAGAGG

AAAAGGACCAGTTTGGCAATATCCAGATCGTAAGGAAAAATATTCCTGAAAACATA

TATCAGGAACTATATAAATACTTTAACGACAAATCCGACAAAGAATTATCCGACGA

GGCTGCAAAGCTGAAGAACGTCGTAGGGCACCATGAGGCAGCGACTAATATTGTGA

AAGACTATAGGTATACATACGACAAATACTTTCTGCACATGCCCATCACGATTAACT

TCAAGGCGAACAAGACGGGATTCATTAACGACCGTATATTACAATATATTGCTAAG

GAGAAAGATCTGCATGTAATAGGTATCGACAGAGGCGAACGTAATTTAATCTACGT

GTCCGTCATCGACACGTGCGGGAACATCGTAGAGCAAAAGAGTTTTAATATAGTAA

ATGGCTATGATTACCAAATTAAGCTAAAGCAGCAAGAAGGAGCAAGACAGATAGCT

AGGAAAGAATGGAAGGAGATAGGAAAAATAAAGGAGATCAAGGAGGGGTATCTTA

GCCTAGTAATTCATGAAATATCTAAGATGGTTATCAAATACAACGCTATCATAGCGA

TGGAAGACTTATCTTATGGTTTCAAGAAAGGAAGGTTCAAAGTAGAGCGTCAAGTTT

ATCAAAAGTTCGAAACGATGTTGATTAATAAACTAAACTATTTGGTATTTAAAGATA

TATCTATCACCGAGAATGGTGGTCTACTAAAGGGTTACCAGCTTACATACATACCGG

ACAAACTTAAAAACGTCGGACATCAGTGTGGATGCATTTTCTACGTTCCAGCTGCAT

ATACCAGCAAGATCGACCCAACGACTGGGTTCGTAAATATTTTTAAATTCAAGGATT

TGACTGTCGACGCCAAAAGAGAGTTCATAAAAAAGTTCGATTCAATTAGGTACGAC

AGCGAAAAGAATTTGTTCTGCTTTACTTTTGACTATAACAATTTCATTACTCAGAAC A

CTGTAATGTCTAAGTCCTCTTGGTCAGTCTATACTTATGGCGTTCGTATCAAACGTA G ATTTGTTAACGGTAGATTCTCAAATGAAAGTGATACAATAGATATCACGAAAGATAT

GGAGAAAACATTAGAAATGACAGACATAAACTGGAGAGACGGACATGACTTGAGA

CAGGACATTATTGACTACGAGATCGTGCAGCACATCTTTGAGATCTTTCGTTTGACC

GTACAAATGCGTAACAGTTTATCTGAGCTTGAGGACAGGGACTACGATAGATTGAT

ATCACCTGTATTAAATGAGAATAACATCTTCTATGATTCCGCAAAAGCAGGCGACGC

TCTACCCAAAGACGCTGATGCGAACGGTGCTTATTGCATAGCTTTAAAGGGTTTGTA

TGAGATCAAACAGATAACAGAAAATTGGAAGGAAGATGGTAAGTTCTCCCGTGACA

AGCTTAAAATATCAAATAAGGACTGGTTCGATTTTATACAGAATAAGCGTTATTA

[0071] SEQ ID NO: 34

ATGAACAATGGAACTAATAACTTCCAGAATTTCATTGGTATCTCCTCTTTACAAAAA

ACTCTAAGAAACGCCCTAATTCCGACTGAAACTACACAGCAATTCATCGTCAAAAAC

GGGATCATTAAGGAGGATGAGTTGAGGGGTGAAAATCGTCAAATTCTTAAAGACAT

CATGGACGACTACTACAGGGGGTTCATCAGCGAGACGTTATCTAGTATAGACGATAT

AGACTGGACTTCACTGTTCGAGAAGATGGAAATCCAATTAAAAAATGGGGACAATA

AAGATACACTTATAAAGGAACAGACAGAGTATAGAAAGGCAATACACAAAAAGTTT

GCCAACGACGATCGTTTCAAGAACATGTTTAGTGCTAAATTGATTTCAGATATTCTG

CCGGAATTTGTTATTCACAACAATAATTATAGCGCCAGTGAGAAAGAAGAAAAAAC

GCAGGTTATCAAACTGTTCAGTCGTTTCGCTACATCTTTTAAGGATTACTTTAAAAA C

CGTGCAAATTGTTTTTCAGCCGACGATATTAGTAGCAGCTCTTGTCACCGTATTGTT A

ATGATAATGCGGAGATTTTCTTTTCAAACGCATTGGTCTACAGGAGGATAGTCAAGT

CCCTTTCAAATGACGACATTAATAAGATCTCAGGTGACATGAAAGATTCCTTAAAGG

AAATGTCCCTGGAAGAGATCTATTCCTATGAAAAGTACGGTGAGTTCATTACTCAAG

AGGGTATAAGCTTTTACAATGACATATGTGGTAAGGTTAATAGCTTTATGAACCTGT

ATTGCCAGAAGAACAAAGAAAATAAGAATCTGTATAAGTTGCAAAAGCTACACAAA

CAAATTTTGTGCATTGCCGATACATCATACGAGGTGCCATACAAATTCGAGAGCGAT

GAGGAGGTTTATCAGAGCGTGAATGGATTCCTGGACAATATTAGTAGTAAGCATATC

GTGGAAAGGCTTAGAAAGATAGGTGACAATTACAATGGCTACAATCTGGATAAAAT

CTACATCGTCTCAAAATTCTATGAAAGTGTATCCCAGAAGACGTACCGTGATTGGGA

AACTATCAACACCGCTCTGGAGATACATTACAACAATATACTTCCCGGAAACGGCA

AGTCAAAAGCCGACAAAGTCAAAAAAGCGGTCAAGAACGATTTACAAAAGTCTATC

ACTGAAATTAATGAATTAGTTAGTAATTACAAACTGTGTAGTGATGATAATATTAAG

GCAGAGACTTACATACACGAAATTTCACACATTTTAAACAACTTCGAGGCACAGGA

ACTTAAATATAATCCTGAAATTCACCTGGTTGAAAGTGAATTGAAAGCCAGCGAGCT

AAAGAACGTTTTGGACGTAATCATGAACGCATTCCACTGGTGCTCTGTCTTTATGAC

AGAGGAACTAGTGGATAAGGACAATAATTTTTATGCGGAGCTGGAGGAAATATACG ATGAGATATATCCCGTAATATCATTATATAATCTGGTAAGAAACTATGTGACTCAAA

AGCCGTATAGCACCAAGAAAATTAAACTTAATTTCGGCATACCCACTTTAGCGGACG

GCTGGTCAAAATCCAAAGAGTATAGTAATAATGCCATCATCCTGATGCGTGACAACC

TGTACTATTTAGGTATATTTAACGCCAAAAATAAACCCGACAAAAAGATTATAGAG

GGCAACACCTCAGAGAACAAAGGTGATTATAAGAAGATGATTTACAACCTTTTACC

CGGTCCTAATAAGATGATTCCCAAAGTCTTTCTATCTAGCAAAACTGGTGTTGAAAC

ATACAAACCCTCAGCTTATATTTTAGAAGGGTATAAGCAGAATAAGCATATTAAAA

GCTCCAAAGATTTCGATATTACCTTTTGCCATGACTTGATAGACTATTTCAAAAATT G

TATTGCCATTCACCCTGAATGGAAAAACTTCGGATTTGACTTCTCTGACACATCCAC

CTACGAAGACATTTCAGGTTTTTACAGGGAAGTCGAGCTACAGGGTTATAAAATTGA

TTGGACATACATCAGCGAGAAAGATATTGACCTACTTCAAGAAAAAGGGCAGCTAT

ACCTGTTCCAGATATACAATAAAGACTTCAGTAAAAAAAGCACCGGGAACGATAAT

CTTCACACAATGTACTTAAAAAATTTATTTAGTGAAGAGAATCTGAAGGATATAGTG

CTGAAGTTAAACGGGGAGGCAGAGATATTTTTTAGAAAATCTAGTATTAAGAATCC

GATCATCCACAAGAAGGGTTCTATCCTTGTTAATAGGACTTATGAGGCAGAAGAAA

AAGACCAATTCGGCAACATACAAATTGTCCGTAAAAATATCCCTGAGAACATTTATC

AGGAACTATACAAGTACTTCAATGATAAAAGCGACAAGGAGCTGAGCGACGAGGCT

GCTAAGTTAAAGAATGTGGTGGGCCACCATGAGGCAGCAACGAATATTGTGAAGGA

CTATCGTTATACCTACGATAAATACTTTCTTCATATGCCGATCACCATTAATTTCAA G

GCAAACAAAACTGGCTTCATTAACGATCGTATCTTACAATATATCGCAAAAGAGAA

AGACCTTCACGTTATCGGGATCGATAGAGGCGAGCGTAACCTAATTTATGTTTCTGT

GATAGACACCTGTGGGAACATAGTCGAACAGAAATCATTTAATATTGTTAACGGCTA

CGATTATCAGATAAAGTTGAAGCAACAAGAGGGTGCACGTCAAATAGCAAGGAAAG

AATGGAAAGAAATAGGCAAGATTAAAGAAATAAAAGAAGGTTATTTATCCCTTGTA

ATACACGAAATTAGCAAAATGGTGATTAAATATAATGCGATCATTGCCATGGAGGA

TCTTTCTTACGGCTTCAAAAAGGGGAGATTCAAAGTCGAGAGGCAGGTGTATCAGA

AGTTTGAGACCATGCTAATCAATAAACTAAATTATCTAGTATTCAAAGACATAAGCA

TCACCGAAAATGGCGGCTTGTTGAAGGGTTATCAATTGACCTACATCCCAGATAAAC

TAAAAAACGTAGGGCATCAATGCGGATGTATATTTTACGTTCCAGCCGCATACACTT

CCAAAATCGATCCAACTACGGGTTTTGTGAACATCTTCAAATTCAAAGACTTGACTG

TCGATGCTAAGAGGGAGTTTATCAAGAAATTTGACTCCATTAGATACGACAGTGAG

AAGAATCTGTTCTGTTTTACCTTTGATTATAACAACTTTATAACTCAAAACACAGTC A

TGAGTAAGTCATCTTGGTCAGTGTATACGTATGGTGTGAGGATTAAAAGGAGGTTTG

TTAACGGGAGATTTTCCAATGAAAGTGATACAATAGATATAACCAAGGACATGGAA

AAGACTCTTGAAATGACCGACATTAACTGGAGAGATGGCCACGACTTACGTCAAGA TATAATCGATTACGAGATAGTGCAACATATCTTTGAGATATTTAGGCTTACTGTCCA

AATGCGTAACTCATTAAGTGAGTTGGAGGACAGGGATTACGATAGGCTAATAAGTC

CTGTTCTTAACGAAAACAATATATTCTACGATTCAGCAAAGGCGGGAGACGCCCTGC

CCAAGGACGCGGATGCTAACGGCGCATACTGTATTGCCCTGAAAGGCTTGTACGAG

ATAAAACAGATCACGGAGAACTGGAAAGAAGATGGAAAATTCAGTCGTGACAAGTT

AAAAATTAGTAACAAAGACTGGTTCGACTTTATTCAGAACAAGAGATATCTG

[0072] SEQ ID NO: 35

ATGAACAACGGAACCAATAACTTTCAAAACTTTATAGGCATCTCCAGTCTACAGAAG

ACACTACGTAACGCTTTGATACCAACTGAGACCACGCAGCAGTTTATCGTCAAGAAC

GGTATTATAAAGGAAGACGAGCTAAGGGGGGAAAACCGTCAGATCTTAAAGGACAT

CATGGATGACTACTACAGAGGCTTCATAAGTGAGACTTTGTCTAGTATAGACGACAT

CGACTGGACCAGTTTATTTGAGAAGATGGAAATTCAGTTAAAGAACGGGGACAATA

AAGACACACTAATTAAAGAGCAGACCGAATACAGAAAAGCTATACACAAAAAGTTT

GCCAACGATGATAGATTCAAAAATATGTTTTCAGCAAAATTGATTTCCGACATATTG

CCAGAATTCGTAATCCATAATAACAATTATTCTGCAAGTGAGAAGGAAGAGAAGAC

CCAAGTAATCAAGCTGTTTTCCCGTTTTGCTACGAGTTTCAAAGATTATTTCAAGAA T

AGGGCTAATTGTTTCTCCGCGGACGACATAAGTAGCAGTTCCTGTCACAGGATTGTG

AACGATAATGCTGAGATATTTTTTTCCAATGCCCTAGTGTATAGGAGAATAGTTAAA

AGCTTAAGCAACGACGATATCAATAAAATTTCAGGGGACATGAAGGACAGCTTAAA

GGAAATGAGTTTGGAGGAGATTTACAGTTATGAAAAATACGGAGAGTTTATAACTC

AGGAAGGCATCTCTTTCTATAATGATATCTGTGGGAAGGTAAACTCCTTCATGAATT

TATATTGCCAGAAGAATAAGGAAAACAAAAATCTTTACAAGCTTCAAAAGTTACAT

AAGCAGATCTTATGTATTGCCGACACGAGTTATGAAGTGCCTTATAAATTCGAGAGT

GATGAGGAAGTGTATCAGTCTGTTAACGGATTCCTAGATAATATAAGTTCCAAACAT

ATAGTCGAGAGGCTGAGGAAGATTGGCGATAACTATAATGGATATAATCTTGACAA

AATCTATATAGTCTCTAAATTTTATGAAAGCGTCAGCCAGAAGACATATAGAGATTG

GGAAACTATAAACACAGCCCTTGAAATACATTACAATAACATCCTACCCGGCAATG

GTAAGTCTAAGGCAGACAAAGTTAAAAAAGCAGTAAAGAATGACTTACAGAAGTCA

ATCACGGAGATAAATGAGTTGGTCAGTAACTACAAATTATGCTCCGACGATAATATT

AAGGCCGAAACATATATACACGAGATAAGTCATATATTAAACAATTTCGAAGCCCA

GGAGTTAAAATATAACCCTGAAATTCATCTGGTCGAAAGTGAGTTAAAGGCCAGTG

AGTTAAAGAATGTACTTGACGTAATTATGAATGCTTTTCATTGGTGCTCCGTGTTCA T

GACCGAGGAGTTAGTAGATAAAGACAATAACTTTTACGCCGAACTTGAAGAGATAT

ACGACGAGATTTATCCGGTAATCAGCTTGTACAACTTAGTTAGAAATTATGTAACAC

AGAAGCCTTACTCTACTAAAAAAATAAAACTGAACTTTGGTATCCCAACTCTTGCAG ATGGTTGGAGTAAAAGCAAGGAATATAGCAACAATGCGATCATCTTGATGAGAGAC

AACTTGTACTATTTGGGAATCTTCAACGCGAAAAATAAACCCGACAAAAAAATCAT

CGAAGGGAATACCTCTGAGAATAAAGGTGACTATAAGAAAATGATTTACAATCTAC

TTCCTGGTCCTAATAAAATGATCCCGAAAGTGTTTCTTAGTTCTAAGACTGGTGTCG

AGACGTACAAACCTAGCGCGTACATCTTAGAAGGGTACAAGCAGAATAAACACATC

AAATCAAGCAAAGACTTCGATATTACTTTTTGCCATGACTTGATAGACTACTTTAAA

AACTGCATAGCAATCCACCCGGAGTGGAAAAACTTTGGCTTTGATTTCTCTGACACC

TCTACATATGAGGACATATCTGGTTTTTACCGTGAGGTTGAATTGCAGGGATACAAA

ATTGACTGGACTTACATATCTGAAAAAGATATCGATCTATTGCAGGAGAAAGGCCA

GCTTTACCTTTTCCAGATCTATAATAAGGACTTCTCTAAGAAGTCTACAGGGAATGA

TAATTTGCACACTATGTACTTAAAAAATCTGTTTTCCGAGGAAAACTTGAAAGACAT

TGTTTTAAAGTTGAACGGAGAAGCTGAAATATTTTTCAGAAAGAGCTCCATAAAAA

ACCCGATCATTCATAAGAAGGGATCTATCCTGGTTAACAGAACGTACGAAGCGGAA

GAAAAAGACCAATTCGGAAACATTCAAATTGTTAGAAAGAATATCCCTGAGAACAT

CTACCAGGAGTTATATAAGTATTTTAATGATAAGTCAGATAAGGAACTATCTGACGA

AGCGGCGAAGCTTAAAAATGTTGTAGGACACCATGAGGCTGCTACAAATATAGTCA

AGGACTACCGTTATACCTACGATAAGTACTTTCTACACATGCCCATTACCATCAATT T

TAAAGCTAATAAAACGGGTTTTATCAACGATCGTATCCTACAATATATTGCGAAAGA

GAAGGATTTGCATGTCATTGGCATTGATAGAGGTGAGAGGAACCTAATATACGTATC

CGTGATTGATACGTGCGGGAACATAGTTGAACAGAAATCATTTAATATAGTTAATGG

GTACGACTATCAGATTAAGCTAAAGCAACAAGAAGGCGCCAGGCAAATTGCCCGTA

AAGAATGGAAAGAGATCGGGAAGATCAAGGAAATAAAAGAAGGATACCTTTCCCT

GGTCATCCATGAAATTAGCAAAATGGTGATTAAGTACAATGCCATAATCGCGATGG

AGGACTTAAGCTACGGGTTCAAAAAGGGGAGGTTTAAGGTGGAGAGGCAAGTGTAC

CAGAAATTTGAGACCATGCTAATCAACAAACTGAACTACCTAGTTTTTAAGGACATT

TCAATTACAGAGAATGGAGGACTTTTAAAGGGTTACCAACTAACGTATATACCAGAT

AAGTTGAAAAATGTCGGTCACCAGTGTGGCTGCATCTTTTACGTTCCCGCCGCTTAT

ACATCTAAAATTGATCCAACCACAGGCTTTGTAAATATCTTTAAATTCAAAGATTTA

ACTGTGGATGCAAAAAGAGAGTTTATCAAGAAATTCGATAGCATTCGTTATGATAGC

GAGAAGAACCTGTTCTGCTTTACTTTCGACTATAACAACTTTATAACTCAAAACACC

GTGATGTCAAAAAGCTCATGGTCAGTCTACACCTATGGTGTAAGGATTAAAAGGCGT

TTCGTGAATGGGAGATTCTCCAATGAAAGTGACACGATCGACATAACAAAGGACAT

GGAGAAGACACTAGAGATGACTGATATTAATTGGAGAGACGGACACGATCTGCGTC

AAGATATAATTGATTATGAGATAGTACAGCACATATTTGAGATCTTCCGTTTGACTG

TCCAAATGCGTAATTCCCTTTCTGAGCTGGAAGATAGGGACTATGATAGATTAATAT CCCCTGTACTAAATGAGAACAACATTTTCTATGATAGTGCAAAAGCCGGGGATGCAT

TGCCGAAAGACGCTGACGCTAATGGGGCGTACTGTATAGCTTTAAAGGGGCTTTACG

AAATAAAGCAGATAACCGAAAACTGGAAGGAAGATGGCAAATTCTCAAGGGACAA

ACTTAAGATCTCTAACAAGGATTGGTTCGATTTTATACAAAACAAACGTTATTTG

[0073] SEQ ID NO:36

ATGAATAATGGTACAAACAACTTTCAGAATTTCATTGGGATCTCTAGCTTACAGAAG

ACCCTGAGGAATGCGTTGATTCCAACTGAAACAACCCAGCAATTCATCGTGAAAAA

TGGGATAATCAAAGAGGATGAGTTAAGGGGTGAAAACCGTCAAATATTGAAGGATA

TTATGGACGACTACTACCGTGGATTCATCTCAGAGACGTTGAGCAGCATTGACGACA

TAGACTGGACTAGCCTTTTCGAGAAGATGGAAATTCAGTTAAAGAACGGAGATAAC

AAAGATACACTAATCAAGGAACAGACAGAATACAGAAAAGCAATTCATAAGAAATT

CGCTAATGACGATCGTTTTAAAAACATGTTCTCTGCAAAATTAATTAGCGACATTCT

GCCGGAATTCGTTATACATAATAATAACTACAGTGCTTCTGAAAAGGAAGAGAAAA

CTCAGGTAATAAAACTGTTCTCTCGTTTTGCCACATCCTTCAAAGACTACTTTAAAA A

TAGAGCGAACTGCTTTAGCGCCGACGATATTAGTTCTTCCTCATGCCACAGGATTGT

CAACGATAATGCAGAGATATTCTTTTCTAACGCACTAGTCTACAGAAGGATTGTAAA

GTCTTTGTCAAATGATGACATAAACAAGATTAGTGGAGATATGAAAGACTCTCTAAA

GGAAATGAGCCTTGAGGAGATATACTCTTATGAAAAGTACGGTGAGTTTATTACCCA

AGAAGGCATTAGTTTCTATAATGACATTTGTGGAAAAGTTAACAGTTTTATGAATCT

ATACTGTCAAAAAAATAAGGAGAATAAAAATCTTTATAAGTTGCAAAAACTGCATA

AGCAGATATTATGTATAGCAGACACGAGCTATGAGGTACCGTACAAGTTCGAGAGC

GATGAGGAAGTCTACCAATCTGTCAACGGATTTTTGGACAACATTTCTTCAAAACAT

ATTGTGGAGAGGCTTAGGAAAATAGGCGACAATTATAATGGATATAACTTAGATAA

GATATATATTGTTTCCAAATTCTACGAATCTGTAAGCCAGAAGACATACAGAGATTG

GGAAACGATAAACACAGCCCTTGAAATTCACTATAACAACATACTACCTGGAAACG

GCAAATCAAAGGCCGACAAAGTTAAGAAGGCCGTAAAGAATGATTTACAGAAGAG

CATAACGGAGATCAATGAGCTGGTGTCTAACTATAAATTGTGTAGCGATGACAACAT

AAAAGCCGAGACTTACATTCACGAAATTTCACACATACTTAACAACTTTGAAGCTCA

GGAATTAAAGTATAATCCCGAAATACACCTTGTGGAGTCCGAACTAAAGGCTAGTG

AGCTTAAGAACGTCCTAGACGTAATTATGAATGCCTTCCACTGGTGTAGTGTTTTTA T

GACCGAGGAACTTGTTGACAAAGATAATAATTTTTATGCAGAACTAGAAGAGATAT

ACGATGAAATATACCCGGTGATCAGTTTGTACAATCTTGTCAGGAACTATGTGACAC

AAAAGCCCTATTCAACAAAGAAAATAAAACTTAATTTCGGAATTCCTACGTTAGCTG

ATGGCTGGTCTAAATCCAAGGAATACAGCAACAACGCTATAATTCTGATGAGAGAT

AACTTGTACTATCTAGGCATCTTCAATGCCAAAAATAAGCCTGATAAGAAGATTATA GAGGGCAACACTTCAGAGAACAAGGGCGACTACAAGAAAATGATCTATAACCTATT

GCCTGGCCCAAACAAGATGATTCCGAAGGTCTTCCTATCATCCAAGACCGGCGTTGA

GACATACAAGCCATCAGCGTATATTTTAGAGGGGTACAAACAAAACAAGCACATAA

AGTCTAGTAAAGACTTCGATATAACATTTTGTCATGACTTAATTGACTACTTTAAGA

ATTGCATCGCTATACACCCGGAATGGAAGAATTTCGGCTTCGACTTCTCTGATACAT

CTACCTACGAGGACATTAGCGGGTTTTACCGTGAAGTCGAATTACAAGGGTATAAG

ATAGATTGGACGTACATCTCTGAGAAAGACATAGACTTGCTTCAGGAAAAGGGCCA

GTTGTATCTATTCCAAATATACAATAAGGATTTTTCCAAGAAATCTACGGGTAATGA

CAATCTTCACACAATGTATCTTAAGAACCTTTTCTCAGAAGAGAACCTGAAGGACAT

TGTCTTAAAACTAAATGGCGAAGCTGAGATTTTTTTCAGGAAGTCTTCAATTAAGAA

CCCGATAATCCACAAGAAGGGGAGTATTCTTGTGAATAGAACTTACGAGGCCGAAG

AAAAAGACCAATTTGGTAACATCCAGATAGTCAGAAAGAACATTCCAGAGAACATC

TACCAAGAGCTATACAAATATTTCAACGACAAGTCCGATAAGGAACTGTCCGATGA

GGCAGCCAAGTTGAAGAATGTCGTGGGTCATCATGAAGCTGCTACTAACATTGTCAA

GGACTATCGTTATACTTACGACAAGTATTTCCTACACATGCCGATAACAATTAATTT

CAAGGCTAACAAAACAGGCTTTATCAACGATCGTATCTTGCAGTACATAGCTAAGG

AAAAGGATTTGCATGTGATTGGCATTGATAGAGGGGAGCGTAACTTGATATATGTGT

CTGT CATAGAC ACGT GT GGC AAC ATCGTCGAAC AGAAATCATTC AAC AT AGTAAAC

GGCTACGATTACCAAATTAAGCTGAAACAGCAAGAGGGTGCACGTCAAATTGCGCG

TAAAGAGTGGAAAGAAATTGGTAAAATCAAGGAAATTAAAGAAGGCTACTTGTCTC

TTGTTATACATGAAATTTCCAAGATGGTTATAAAGTATAACGCGATAATTGCTATGG

AAGACTTATCATACGGGTTTAAAAAGGGGAGGTTCAAGGTAGAGAGGCAGGTCTAT

CAAAAGTTCGAGACGATGTTGATTAATAAACTAAACTATCTAGTGTTCAAAGATATC

AGCATTACGGAGAACGGGGGGCTACTGAAAGGATATCAACTAACGTACATTCCCGA

TAAGTTAAAGAACGTTGGTCATCAATGTGGTTGCATCTTCTACGTGCCTGCTGCCTA T

ACGTCCAAAATAGATCCAACTACTGGATTTGTTAACATCTTTAAATTCAAAGATTTA

ACCGTAGACGCCAAAAGGGAATTTATAAAAAAATTTGACAGCATCCGTTACGATAG

CGAAAAGAATCTGTTCTGTTTTACTTTCGACTACAATAATTTCATCACGCAAAATAC

GGTAATGTCTAAGTCAAGTTGGAGCGTCTACACGTATGGAGTCAGGATCAAGAGGC

GTTTCGTAAATGGAAGATTCTCTAATGAGTCAGATACTATAGACATCACGAAAGATA

TGGAGAAAACCTTGGAGATGACGGATATTAACTGGCGTGATGGACACGATTTAAGA

CAGGACATTATTGACTATGAGATTGTGCAACACATCTTCGAAATATTCCGTCTAACA

GTCCAAATGAGGAATAGCCTAAGTGAATTGGAGGACCGTGATTACGATAGGCTTAT

AAGTCCTGTCCTTAACGAAAACAATATTTTCTATGATAGTGCTAAGGCGGGGGACGC

ACTGCCTAAAGACGCAGATGCTAACGGGGCATACTGCATTGCGTTAAAGGGTCTGT ACGAAATCAAGCAGATTACGGAAAACTGGAAAGAGGATGGCAAGTTTAGCAGAGA

TAAGTTGAAGATAAGTAACAAAGATTGGTTTGACTTTATTCAGAATAAAAGGTATTT

A

[0074] SEQ ID NO: 37

ATGAATAACGGCACTAATAATTTCCAGAATTTCATCGGCATTAGCAGCTTACAAAAG

ACGTTGAGGAATGCCTTAATACCCACAGAAACTACTCAACAATTTATAGTGAAGAAT

GGGATAATTAAGGAAGACGAGTTGAGAGGTGAAAATAGGCAAATCTTGAAAGACAT

TATGGATGACTACTACAGGGGCTTCATTAGTGAAACGTTGTCTTCAATAGATGACAT

TGATTGGACTTCTTTGTTTGAGAAGATGGAAATACAGTTAAAGAACGGCGACAATA

AGGATACACTTATCAAAGAGCAAACAGAATATAGAAAAGCAATTCACAAAAAGTTT

GCTAACGATGATAGGTTCAAGAACATGTTTAGCGCTAAACTAATATCAGACATCCTT

CCCGAGTTCGTTATTCATAACAATAACTATAGTGCAAGTGAAAAAGAGGAGAAGAC

ACAGGTGATTAAGCTGTTCTCCAGATTCGCGACTTCTTTCAAAGATTACTTCAAAAA

CAGAGCCAACTGTTTTTCAGCTGACGATATCTCTAGTAGTAGTTGTCACCGTATAGT

GAACGATAACGCTGAGATCTTCTTTAGCAATGCATTAGTGTATAGAAGGATAGTTAA

GTCTCTAAGCAATGATGATATCAATAAAATTTCCGGAGACATGAAGGACTCCCTAAA

GGAAATGTCCTTAGAAGAGATCTACTCATATGAGAAATACGGGGAATTTATTACGC

AGGAAGGGATCTCCTTTTACAATGACATATGCGGGAAGGTCAACTCTTTCATGAACT

TATACTGCCAAAAGAACAAGGAGAACAAGAATTTATATAAACTTCAGAAACTTCAC

AAACAAATACTGTGCATAGCCGATACCTCATATGAGGTTCCTTACAAATTTGAATCA

GATGAAGAGGTATACCAATCCGTTAACGGCTTTCTTGACAATATTAGCTCAAAGCAC

ATCGTGGAGAGGTTGAGAAAGATTGGTGATAATTATAATGGCTACAATCTAGATAA

GATATATATTGTTAGCAAGTTCTACGAGTCTGTGTCCCAAAAAACATATAGGGATTG

GGAGACAATTAATACTGCTCTAGAAATCCATTACAACAACATCCTTCCTGGAAATGG

CAAGAGTAAGGCCGACAAAGTCAAGAAAGCAGTGAAAAATGATCTGCAAAAATCA

ATTACTGAGATAAACGAGCTAGTATCTAATTACAAGCTTTGTAGCGACGATAACATT

AAGGCAGAAACGTACATACACGAGATTAGTCACATCTTAAATAATTTTGAAGCCCA

AGAACTGAAATATAACCCTGAGATACACCTTGTTGAATCCGAGTTAAAGGCGTCTGA

ACTAAAAAACGTGTTAGACGTTATTATGAATGCCTTCCACTGGTGTAGCGTCTTTAT

GACTGAGGAGTTGGTTGATAAGGATAATAACTTTTACGCTGAATTGGAAGAAATTTA

TGACGAAATCTATCCTGTTATTTCTCTATATAATTTGGTGAGAAATTACGTAACGCA

AAAGCCCTATAGTACGAAAAAAATAAAACTAAATTTCGGGATCCCTACCCTAGCCG

ACGGTTGGTCTAAATCCAAGGAGTACTCAAACAATGCAATAATATTGATGAGGGAC

AACCTGTACTACCTAGGCATATTTAATGCCAAAAATAAGCCCGATAAAAAGATTATA

GAAGGGAACACGTCAGAAAATAAAGGAGACTATAAGAAAATGATCTACAACCTTTT GCCCGGCCCCAATAAAATGATCCCGAAGGTCTTCCTAAGTAGCAAGACTGGCGTAG

AGACCTACAAACCATCTGCATACATTTTGGAGGGGTACAAGCAAAACAAGCACATA

AAGAGTAGTAAGGATTTTGACATTACATTCTGCCATGACTTAATTGACTACTTTAAA

AATTGCATCGCAATTCACCCTGAATGGAAAAATTTTGGATTTGATTTCTCTGATACT T

CAACATATGAGGATATTTCAGGGTTCTACAGGGAGGTCGAACTACAGGGTTACAAA

ATAGACTGGACGTATATTTCTGAGAAAGATATAGATTTGCTTCAGGAAAAGGGTCA

GCTATATCTGTTCCAGATATATAATAAGGACTTCTCCAAAAAGAGTACCGGAAATGA

TAATCTGCACACAATGTACTTAAAAAACTTGTTCTCTGAGGAGAATCTAAAAGACAT

CGTACTAAAACTTAACGGGGAGGCCGAAATTTTTTTTAGGAAGTCCAGCATCAAGA

ACCCGATTATTCATAAAAAAGGTAGCATTTTGGTGAACCGTACTTATGAGGCGGAAG

AAAAAGACCAATTCGGTAATATTCAAATCGTTAGAAAGAACATCCCTGAGAACATT

TATCAGGAACTATACAAATACTTTAACGACAAATCAGATAAGGAGCTTTCTGATGAG

GCAGCTAAATTGAAAAATGTAGTGGGACATCACGAAGCAGCCACTAACATAGTGAA

GGACTACAGATACACATACGATAAGTACTTCCTGCACATGCCTATTACAATTAACTT

TAAAGCAAATAAAACAGGGTTTATTAACGACAGAATCTTACAGTATATTGCCAAAG

AAAAGGATCTGCATGTGATAGGAATAGACAGAGGAGAAAGAAACCTGATATACGTC

TCCGTGATTGATACATGTGGGAACATAGTAGAACAGAAGTCCTTTAACATTGTTAAT

GGGTACGATTATCAAATTAAATTAAAACAACAAGAAGGAGCACGTCAAATAGCTAG

GAAAGAATGGAAAGAGATAGGAAAAATTAAGGAAATTAAGGAGGGTTACCTGTCC

CTTGTAATTCATGAAATATCCAAAATGGTAATTAAATATAACGCGATCATCGCGATG

GAAGATCTAAGCTACGGGTTCAAAAAAGGCAGGTTTAAGGTGGAGAGGCAAGTTTA

CCAAAAGTTCGAGACAATGTTGATTAATAAGTTAAACTACTTAGTTTTCAAAGATAT

CTCCATAACCGAGAATGGCGGGCTTTTAAAAGGGTACCAACTAACATATATCCCGG

ATAAATTGAAGAACGTTGGACACCAGTGTGGCTGCATATTTTATGTACCCGCTGCGT

ATACTTCTAAAATTGACCCGACCACCGGGTTTGTAAACATATTCAAGTTTAAGGACC

TAACAGTTGACGCCAAACGTGAGTTCATCAAGAAGTTCGATAGTATAAGGTATGACT

CTGAGAAGAACCTTTTCTGCTTCACGTTTGACTATAATAATTTCATCACCCAAAATA C

AGTTATGTCAAAAAGCTCTTGGTCAGTATATACGTATGGCGTAAGGATTAAGCGTAG

GTTCGTGAACGGTAGATTTTCCAACGAGTCAGATACTATTGATATTACCAAGGATAT

GGAGAAGACATTAGAAATGACAGATATAAATTGGAGGGATGGGCACGATCTAAGGC

AAGATATCATTGATTACGAAATTGTTCAGCACATATTCGAGATATTCCGTCTTACAG

TACAAATGCGTAACAGCTTGTCTGAGTTGGAAGATCGTGACTATGACAGGTTGATAT

CACCGGTCTTGAACGAGAACAATATATTCTACGACAGCGCTAAGGCGGGAGACGCT

CTGCCTAAAGACGCAGATGCCAATGGGGCGTACTGCATTGCCTTAAAAGGCTTATAC GAGATTAAACAGATCACAGAGAACTGGAAAGAGGACGGCAAGTTTTCTAGAGATAA

ATTGAAAATCTCAAACAAAGACTGGTTCGATTTCATCCAAAACAAAAGATACCTT

[0075] SEQ ID NO: 38

ATGAACAATGGAACTAACAACTTCCAGAACTTTATCGGCATCTCTTCCCTCCAAAAG

ACACTGAGAAATGCACTGATCCCAACCGAAACGACTCAACAATTTATTGTTAAGAA

CGGCATCATAAAAGAAGACGAGCTTCGCGGCGAGAACCGCCAGATACTTAAGGATA

TTATGGACGATTATTACCGAGGCTTTATCAGCGAAACTCTTAGCTCTATTGATGATA T

CGACTGGACCTCCCTCTTCGAAAAAATGGAGATACAGCTCAAGAACGGCGATAATA

AAGACACCTTGATAAAGGAACAGACTGAGTACAGGAAAGCGATCCACAAGAAATTC

GCGAACGACGACAGGTTTAAAAACATGTTCTCTGCAAAATTGATATCCGACATCTTG

CCGGAATTTGTGATACACAACAATAACTATAGCGCTTCAGAGAAAGAAGAGAAGAC

CCAAGTAATCAAGTTGTTCAGCCGCTTCGCAACGTCTTTTAAAGATTACTTTAAGAA

CCGGGCCAATTGTTTCTCCGCGGATGATATTAGCTCATCAAGTTGCCATCGAATTGT

CAATGATAATGCGGAGATCTTCTTCAGCAATGCGCTGGTCTACAGACGAATCGTAAA

AAGTCTTTCAAATGACGACATCAATAAGATTAGTGGAGATATGAAGGATTCCCTTAA

GGAAATGAGTCTTGAAGAAATATACTCATACGAAAAGTACGGGGAATTTATTACCC

AGGAGGGGATCTCCTTCTATAACGACATCTGTGGAAAAGTAAACTCATTCATGAACC

TGTACTGTCAGAAAAACAAAGAAAACAAAAATCTGTATAAACTCCAAAAATTGCAC

AAGCAAATATTGTGTATAGCGGACACATCATACGAGGTTCCATATAAGTTCGAAAGT

GATGAAGAAGTCTACCAATCAGTGAATGGGTTTCTGGACAACATTAGTTCCAAGCAC

ATAGTTGAACGACTGCGAAAGATTGGTGACAATTACAACGGCTATAATTTGGACAA

GATTTATATAGTTAGCAAATTTTATGAATCCGTATCACAAAAGACTTATAGAGACTG

GGAAACAATCAACACGGCACTTGAGATCCATTATAACAATATTCTTCCAGGGAACG

GCAAAAGCAAGGCTGATAAGGTAAAAAAGGCCGTTAAGAATGATCTTCAAAAATCC

ATAACGGAGATCAACGAACTTGTAAGTAACTACAAATTGTGCTCTGACGACAATAT

AAAGGCTGAAACGTATATTCACGAGATTAGCCATATCCTGAATAACTTTGAGGCCCA

AGAACTCAAGTATAACCCGGAAATACATTTGGTAGAAAGCGAGCTTAAAGCGAGTG

AGCTGAAAAACGTCCTCGATGTGATCATGAATGCTTTCCACTGGTGTAGTGTCTTTA

TGACTGAGGAGTTGGTTGATAAAGACAATAATTTCTACGCTGAACTGGAAGAAATTT

ACGACGAAATCTATCCAGTGATCTCCCTCTATAACCTCGTTCGAAACTACGTGACGC

AGAAACCTTATTCTACAAAGAAAATTAAGTTGAACTTCGGCATTCCTACACTTGCTG

ACGGATGGTCCAAATCCAAAGAGTACTCAAACAACGCAATCATCCTCATGCGGGAT

AACCTTTATTATTTGGGCATTTTCAACGCCAAAAACAAACCTGATAAAAAGATAATT

GAAGGCAATACGAGTGAGAACAAGGGCGACTACAAAAAAATGATATATAACTTGTT

GCCAGGCCCCAACAAGATGATTCCTAAAGTTTTTCTGTCTTCTAAGACTGGAGTTGA AACTTACAAACCCTCCGCCTACATTCTTGAAGGGTATAAACAGAATAAGCACATAA

AGTCCTCAAAGGATTTCGACATTACGTTTTGCCATGACCTCATCGACTATTTCAAGA

ACTGTATCGCCATACATCCGGAGTGGAAGAATTTTGGATTTGATTTCTCCGACACAT

CTACCTATGAAGACATAAGCGGTTTCTACCGGGAGGTCGAGCTTCAGGGCTATAAG

ATAGATTGGACATACATTAGTGAAAAAGATATCGATCTTCTGCAAGAAAAGGGACA

ACTTTACCTTTTTCAGATTTATAATAAAGACTTTTCAAAAAAGTCCACAGGGAACGA

TAATCTGCACACCATGTATCTCAAGAATCTGTTTAGTGAAGAAAACCTTAAAGACAT

AGTTTTGAAGCTTAACGGAGAGGCTGAGATTTTTTTTAGAAAGTCCTCAATTAAAAA

CCCTATAATACACAAGAAAGGCTCTATTCTTGTTAACAGGACATATGAAGCCGAGG

AGAAAGATCAGTTTGGCAATATCCAGATTGTTCGCAAGAATATCCCGGAAAATATAT

ATCAGGAGCTGTATAAATACTTTAACGACAAGAGCGACAAGGAGCTGAGTGACGAG

GCCGCGAAGCTTAAGAATGTAGTAGGTCACCACGAAGCAGCCACCAATATCGTCAA

AGACTATAGGTACACGTACGACAAGTACTTTTTGCACATGCCTATAACTATAAACTT

CAAAGCTAATAAAACTGGGTTTATTAATGACAGGATTCTCCAATACATCGCTAAAGA

GAAGGATCTGCATGTAATTGGCATAGACAGAGGTGAGAGAAACTTGATATATGTCA

GCGTAATAGACACATGTGGCAATATCGTGGAACAGAAGTCTTTTAACATCGTCAATG

GTTACGACTACCAAATTAAGTTGAAACAGCAGGAAGGCGCACGACAGATCGCACGA

AAGGAATGGAAAGAGATAGGCAAAATAAAAGAAATAAAGGAGGGCTATCTCAGTC

TCGTTATACACGAAATTTCAAAAATGGTTATTAAGTACAATGCAATCATAGCGATGG

AGGATCTCAGTTATGGGTTCAAAAAGGGTCGGTTTAAAGTTGAGCGCCAAGTGTACC

AAAAGTTCGAGACAATGCTGATTAACAAGCTGAACTACCTCGTCTTCAAAGATATAA

GTATTACGGAGAACGGTGGCCTTCTTAAAGGCTATCAACTTACTTACATCCCGGACA

AGCTCAAAAACGTAGGGCACCAATGCGGGTGTATTTTCTATGTGCCTGCGGCATATA

CGTCAAAGATTGACCCAACCACAGGATTCGTAAACATATTCAAGTTTAAGGACCTCA

CCGTTGATGCGAAAAGGGAGTTCATTAAAAAATTTGATTCTATTCGATATGATAGTG

AGAAAAATCTCTTTTGTTTCACATTTGACTATAATAATTTTATTACTCAGAATACTG T

CATGAGCAAGTCATCTTGGTCAGTGTACACATACGGGGTGCGGATCAAACGCAGGT

TCGTCAATGGTCGCTTCTCAAACGAATCAGACACCATTGACATCACAAAGGACATGG

AAAAAACCCTTGAGATGACCGACATTAATTGGCGCGATGGTCATGATCTGCGGCAA

GACATCATAGACTACGAAATCGTCCAACACATCTTTGAGATCTTTCGCTTGACGGTC

CAAATGCGGAACTCCCTGTCCGAGCTCGAGGATAGAGATTATGATCGGCTGATATCT

CCCGTGCTTAATGAAAATAACATCTTCTACGACTCCGCCAAGGCGGGTGATGCCCTG

CCGAAGGATGCGGATGCTAATGGCGCTTATTGCATTGCTCTTAAGGGGCTCTATGAG

ATAAAGCAGATCACGGAAAACTGGAAAGAAGACGGTAAGTTTAGTAGAGACAAGC

TGAAGATCTCAAATAAAGACTGGTTTGATTTCATACAG. AAC. AAG. CGG. TAC. CTG [0076] SEQ ID NO: 39

ATGAACAATGGCACTAACAATTTTCAGAATTTCATCGGCATTTCAAGTCTGCAAAAA

ACTCTGAGGAATGCTTTGATCCCTACTGAAACCACTCAGCAATTTATAGTCAAGAAC

GGTATAATTAAAGAAGATGAACTCAGGGGTGAAAATAGACAAATACTCAAGGACAT

TATGGATGACTATTATAGAGGCTTCATCTCAGAGACTCTCTCATCAATAGATGATAT

CGATTGGACTAGCCTTTTCGAGAAAATGGAGATTCAGTTGAAAAATGGTGATAACA

AAGATACGTTGATAAAGGAACAGACCGAGTACAGGAAAGCCATTCATAAGAAATTT

GCTAATGACGATAGATTTAAGAATATGTTTAGTGCAAAACTGATTAGTGACATTCTG

CCGGAGTTCGTTATCCATAATAATAACTACTCTGCATCCGAAAAGGAGGAAAAGAC

GCAAGTTATTAAACTGTTCAGCCGCTTCGCCACAAGCTTCAAGGACTACTTCAAAAA

TAGAGCCAACTGCTTTTCTGCCGACGATATATCATCATCTTCATGCCATCGGATCGT T

AACGATAACGCCGAGATATTCTTCAGCAACGCCCTTGTATATCGAAGAATAGTCAAA

AGTCTGAGTAATGATGATATTAATAAAATTAGCGGTGATATGAAAGACTCCCTGAA

GGAAATGTCACTGGAGGAAATTTATAGTTACGAAAAGTACGGCGAATTCATTACTC

AAGAAGGCATATCCTTCTATAACGACATTTGCGGAAAGGTCAACTCATTCATGAACC

TTTATTGCCAGAAGAATAAGGAGAATAAAAATCTTTACAAATTGCAAAAACTTCAC

AAACAAATTCTTTGCATCGCGGATACGTCCTACGAAGTTCCTTACAAATTTGAATCC

GATGAGGAAGTGTATCAGAGTGTCAATGGATTTTTGGATAATATCTCTTCAAAACAT

ATTGTGGAGAGATTGCGCAAAATAGGTGATAACTACAATGGCTACAACCTGGACAA

GATTTATATTGTTAGCAAGTTCTATGAAAGTGTCAGTCAAAAGACCTACAGAGATTG

GGAGACAATCAACACGGCGCTCGAAATACACTACAATAACATCCTCCCCGGCAATG

GGAAGAGTAAAGCCGATAAGGTTAAAAAAGCTGTTAAGAACGACCTCCAGAAATCC

ATCACGGAAATAAACGAGCTGGTTTCCAACTATAAGCTGTGTAGCGATGATAATATT

AAGGCTGAGACATATATACATGAGATCAGCCACATTCTCAACAATTTCGAGGCACA

GGAACTCAAATACAATCCCGAGATTCACTTGGTGGAAAGTGAGTTGAAGGCGTCAG

AGCTTAAGAATGTACTTGACGTAATAATGAATGCTTTTCATTGGTGCTCCGTGTTCA T

GACTGAGGAACTCGTGGATAAGGATAATAACTTTTATGCGGAGTTGGAAGAGATAT

ACGATGAAATATACCCGGTTATCTCACTGTATAATCTGGTCAGAAATTACGTGACCC

AAAAGCCTTATAGTACAAAAAAAATAAAGTTGAACTTCGGTATTCCGACATTGGCA

GATGGTTGGTCCAAAAGCAAAGAATACTCTAATAACGCCATTATATTGATGCGAGA

CAATTTGTATTACCTTGGGATCTTTAACGCGAAAAACAAACCGGATAAGAAGATCAT

CGAAGGTAATACATCTGAGAATAAGGGGGATTACAAGAAGATGATTTATAATCTGT

TGCCGGGGCCAAACAAGATGATTCCGAAGGTCTTTCTGTCATCTAAGACAGGAGTA

GAGACCTACAAACCTTCTGCGTACATTTTGGAAGGCTACAAACAGAACAAGCATAT

AAAATCTAGCAAGGACTTTGATATCACGTTTTGTCATGATCTGATAGATTATTTCAA AAACTGCATCGCTATACATCCTGAGTGGAAGAATTTCGGCTTTGACTTTTCTGACAC

CAGCACATACGAAGACATCTCAGGTTTCTACCGGGAAGTCGAGCTCCAGGGGTACA

AGATTGACTGGACATATATAAGTGAAAAAGACATCGACCTCCTCCAAGAGAAGGGC

CAACTTTACCTGTTCCAGATCTATAACAAAGACTTTTCTAAAAAGTCCACGGGTAAC

GACAACTTGCACACTATGTATCTGAAAAACTTGTTCTCTGAAGAGAACCTCAAGGAC

ATCGTCCTGAAGCTTAACGGGGAGGCGGAGATCTTCTTTAGAAAGTCCTCTATCAAA

AATCCCATTATCCATAAAAAGGGCTCTATACTCGTTAATAGGACATATGAAGCGGAG

GAAAAAGATCAATTTGGGAACATCCAGATCGTCCGGAAAAATATACCTGAGAATAT

CTATCAAGAGCTGTACAAGTATTTTAATGATAAGTCAGACAAAGAGCTCAGTGATG

AGGCGGCAAAGCTCAAGAACGTGGTGGGGCATCATGAAGCTGCGACGAACATTGTC

AAAGATTATAGATACACTTACGATAAATACTTCCTCCACATGCCGATAACGATTAAC

TTCAAAGCCAATAAGACGGGGTTTATAAATGATCGGATCCTTCAGTACATTGCGAAA

GAGAAAGACCTCCATGTGATCGGAATTGACCGAGGAGAAAGGAATCTGATTTACGT

GTCCGTGATTGATACTTGCGGGAATATAGTCGAGCAAAAGAGTTTCAACATAGTCAA

CGGGTATGACTATC AGATAA AGCTCAAAC AGCAGGAAGGT GCGAGGC AAATTGCGC

GCAAAGAGTGGAAGGAGATAGGCAAGATTAAAGAAATCAAGGAAGGTTATCTCAG

CTTGGTGATCCATGAAATATCTAAGATGGTTATAAAGTACAATGCCATAATAGCCAT

GGAGGATCTTTCCTACGGGTTTAAGAAGGGCCGATTTAAAGTGGAGCGACAAGTTT

ACCAGAAGTTCGAAACCATGTTGATTAACAAACTTAACTATTTGGTGTTCAAGGATA

TAAGTATAACCGAAAACGGCGGTTTGCTTAAGGGTTATCAGCTCACGTATATTCCTG

ATAAACTTAAAAACGTTGGACACCAGTGTGGATGTATCTTCTACGTGCCAGCCGCTT

ACACTAGTAAGATAGATCCTACCACGGGGTTTGTGAATATTTTTAAGTTTAAAGACT

TGACAGTCGACGCCAAAAGGGAATTTATAAAAAAGTTTGATTCTATCCGCTACGATA

GTGAAAAAAATCTCTTTTGCTTTACTTTCGACTATAACAACTTCATTACGCAGAACA

CTGTCATGAGTAAGTCCAGCTGGAGCGTCTACACATATGGCGTCCGAATTAAACGAC

GATTTGTAAACGGGCGGTTTTCAAACGAATCTGACACGATAGACATTACCAAGGAT

ATGGAGAAGACACTTGAGATGACCGACATAAACTGGCGGGACGGTCACGATCTTCG

GCAGGACATAATTGATTACGAAATCGTCCAGCATATATTCGAAATATTTCGACTTAC

AGTGCAAATGCGGAACAGTCTCTCTGAACTGGAAGATCGCGATTATGACCGGTTGAT

TTCTCCGGTCCTCAATGAAAATAACATATTTTATGATAGTGCTAAGGCAGGTGATGC

GTTGCCAAAGGATGCAGACGCTAATGGTGCCTATTGTATCGCGCTCAAGGGATTGTA

CGAGATAAAGCAAATTACGGAGAACTGGAAGGAGGATGGTAAGTTTAGCCGAGAC

AAGTTGAAGATTAGCAATAAAGACTGGTTTGATTTTATCCAAAACAAGAGGTACCTG

[0077] SEQ ID NO: 40 ATGAATAACGGAACTAATAACTTTCAAAATTTCATAGGTATTTCAAGCTTGCAGAAG

ACCCTGAGGAATGCCCTGATTCCAACCGAGACAACGCAGCAGTTCATAGTCAAAAA

TGGCATTATTAAGGAAGATGAGCTGCGGGGGGAAAACCGACAGATACTCAAGGATA

TTATGGACGACTATTACCGGGGATTTATCTCAGAAACGCTGAGCAGTATTGATGACA

TCGATTGGACCAGTCTTTTCGAGAAAATGGAAATTCAACTTAAGAATGGTGACAATA

AAGACACTCTCATAAAGGAGCAAACTGAATACCGAAAAGCCATACACAAAAAGTTT

GCCAACGATGACCGCTTTAAAAACATGTTTTCAGCTAAGCTCATTAGCGACATTCTC

CCCGAGTTTGTGATTCATAACAATAACTATAGCGCATCCGAGAAGGAGGAAAAAAC

CCAAGTTATCAAATTGTTCAGTAGATTCGCTACGAGCTTTAAAGATTACTTTAAAAA

CCGGGCTAACTGCTTCAGTGCAGACGATATCAGCTCCTCATCCTGTCATCGCATCGT

CAATGATAATGCTGAGATCTTCTTTTCTAATGCACTGGTTTACCGCAGGATAGTTAA

GTCTCTTAGTAACGACGACATCAACAAGATATCAGGAGATATGAAGGATTCCCTTAA

AGAAATGAGTCTCGAGGAGATATATTCTTATGAAAAATACGGCGAATTTATTACCCA

AGAGGGCATTAGTTTCTATAATGACATATGCGGAAAAGTTAATAGTTTTATGAATCT

CTATTGTCAGAAGAATAAGGAGAATAAGAACCTCTACAAATTGCAGAAGTTGCACA

AGCAAATTCTGTGTATCGCGGACACCTCTTACGAGGTCCCATATAAGTTCGAGAGTG

ATGAAGAAGTATACCAGAGCGTTAATGGGTTCCTGGACAACATCTCAAGTAAACAC

ATAGTCGAAAGGCTCCGAAAGATCGGTGATAACTATAACGGATATAATTTGGATAA

AATTTATATAGTTAGCAAATTTTACGAGAGCGTCAGTCAGAAGACCTACCGGGACTG

GGAGACCATAAACACAGCGCTGGAAATACATTATAACAACATACTGCCTGGGAACG

GT AAGT C AAAGGCAGAC AAGGTTAAAAAGGCTGT GAAGAATGACCTGC AAAAATC A

ATTACAGAAATAAATGAGTTGGTAAGTAATTACAAACTTTGCAGCGATGATAATATA

AAGGCAGAGACGTACATACATGAAATATCTCATATCCTCAACAATTTCGAAGCCCA

AGAACTGAAGTACAACCCGGAAATTCATCTTGTAGAGTCTGAGTTGAAGGCCTCCG

AATTGAAAAACGTTCTTGACGTAATTATGAATGCCTTCCACTGGTGCTCAGTATTCA

TGACGGAAGAGCTCGTGGATAAAGACAACAATTTTTACGCTGAACTGGAAGAAATA

TATGACGAGATTTACCCCGTAATTTCACTCTACAACTTGGTACGAAATTACGTTACC

CAAAAGCCATACTCAACAAAAAAAATTAAACTGAACTTCGGGATACCCACCCTCGC

AGATGGATGGTCAAAGTCCAAAGAGTACAGTAACAATGCAATTATCCTGATGCGAG

ACAACCTTTATTACCTCGGGATTTTCAACGCTAAAAATAAACCTGATAAAAAAATAA

TTGAGGGTAATACCTCTGAAAACAAGGGGGATTATAAAAAGATGATATACAATCTG

CTGCCTGGCCCGAACAAAATGATTCCTAAAGTCTTCTTGTCTTCCAAGACTGGAGTC

GAAACCTACAAGCCAAGTGCTTATATACTCGAAGGGTACAAACAAAATAAGCACAT

AAAATCCAGCAAGGATTTTGATATTACATTCTGCCACGATTTGATTGATTATTTTAA G

AACTGTATAGCCATCCACCCAGAATGGAAGAATTTTGGTTTTGATTTTAGCGATACC TCAACATATGAGGATATCTCTGGCTTTTACCGCGAGGTAGAACTGCAAGGTTATAAG

ATCGATTGGACTTATATTTCTGAAAAGGACATAGATCTCCTGCAAGAGAAAGGGCA

ACTTTATTTGTTTCAAATATACAACAAAGATTTTAGTAAGAAGAGTACTGGCAATGA

TAACCTTCACACTATGTATCTGAAGAACCTTTTTTCTGAGGAGAACTTGAAGGACAT

AGTCCTTAAACTCAATGGGGAAGCTGAAATATTCTTTCGCAAAAGCTCCATTAAAAA

CCCGATCATTCATAAAAAGGGTTCCATCTTGGTAAACCGCACATACGAGGCGGAAG

AAAAAGATCAGTTCGGAAATATCCAGATCGTAAGGAAGAATATCCCCGAAAATATA

TACCAAGAGCTTTACAAATATTTTAACGATAAGTCAGACAAGGAACTGTCAGACGA

AGCAGCCAAGTTGAAGAATGTCGTAGGGCACCACGAAGCAGCTACAAACATAGTTA

AAGATTATCGGTACACCTACGATAAATATTTCCTGCATATGCCAATAACCATAAACT

TCAAAGCCAACAAAACAGGGTTCATCAATGACCGAATACTTCAGTATATAGCCAAG

GAAAAAGACCTGCATGTTATAGGAATAGATAGAGGTGAGCGCAACTTGATATATGT

CAGCGTGATAGACACCTGCGGAAATATCGTCGAGCAAAAAAGTTTCAACATTGTTA

ATGGCTACGATTACCAAATTAAATTGAAGCAGCAAGAGGGGGCTCGGCAAATCGCG

CGAAAGGAATGGAAAGAAATCGGGAAGATTAAAGAAATTAAAGAGGGCTACCTGT

CTCTTGTAATTCACGAAATATCTAAGATGGTCATCAAGTATAATGCCATTATTGCGA

TGGAAGATCTGTCCTACGGATTTAAGAAAGGCAGGTTTAAAGTCGAAAGGCAGGTG

TACCAGAAATTCGAGACCATGCTGATTAATAAGCTCAACTATCTCGTATTTAAGGAT

ATTTCTATAACTGAAAATGGAGGGCTTCTCAAAGGATATCAACTCACATACATACCT

GATAAGCTGAAGAACGTAGGCCACCAGTGTGGATGCATATTCTATGTACCAGCTGC

ATACACAAGCAAGATCGATCCAACTACTGGGTTTGTCAATATCTTCAAATTTAAGGA

CTTGACGGTCGATGCCAAACGGGAGTTCATCAAAAAGTTTGATAGTATTCGATATGA

TAGTGAGAAGAACTTGTTTTGCTTCACATTTGACTACAACAATTTCATAACGCAAAA

TACGGTTATGTCTAAATCCTCATGGAGCGTCTACACTTACGGAGTGAGGATAAAGCG

GCGCTTCGTAAATGGCAGGTTTAGCAATGAATCCGACACGATTGACATAACCAAGG

ATATGGAGAAAACCCTCGAGATGACCGATATAAATTGGCGGGATGGACACGATCTG

CGACAAGACATAATCGATTATGAAATCGTGCAGCACATATTTGAGATATTCAGGCTT

ACGGTCCAAATGAGAAATTCCCTTTCCGAACTTGAAGACCGCGATTACGACCGACTG

ATAAGCCCCGTTCTGAACGAAAATAACATCTTCTACGACAGCGCTAAAGCGGGAGA

CGCGCTGCCGAAAGATGCGGACGCAAATGGAGCCTATTGTATCGCCTTGAAAGGGT

TGTACGAGATCAAACAGATAACCGAGAATTGGAAGGAGGATGGGAAGTTTAGTCGA

GACAAACTTAAAATAAGCAACAAGGACTGGTTCGACTTTATTCAAAACAAACGATA

TCTC

[0078] SEQ ID NO: 41 ATGAATAATGGTACTAACAATTTTCAAAACTTTATCGGCATCTCTTCACTTCAGAAA

ACTCTTCGGAACGCCCTTATACCGACGGAGACAACGCAGCAGTTTATAGTTAAAAAC

GGGATCATTAAAGAAGATGAACTCAGAGGGGAAAACAGGCAAATATTGAAGGACA

TTATGGACGATTACTACCGGGGGTTTATTTCAGAGACCCTTTCATCTATTGATGACA T

AGATTGGACCTCCCTTTTCGAGAAAATGGAGATACAATTGAAAAACGGCGACAATA

AAGATACACTTATCAAGGAACAAACTGAGTATCGCAAGGCGATTCACAAGAAGTTT

GCGAATGACGATCGCTTTAAGAATATGTTTTCTGCGAAGCTCATAAGTGACATTCTG

CCTGAATTTGTCATTCATAACAACAATTATTCTGCTAGCGAAAAAGAGGAAAAAACT

CAAGTCATTAAGCTTTTTAGCAGGTTCGCTACTAGTTTTAAAGACTATTTTAAGAAC C

GGGCGAATTGCTTTAGCGCTGACGACATATCATCCTCATCCTGTCATCGCATAGTCA

ATGATAATGCAGAAATATTCTTTTCTAATGCGCTCGTGTATCGGAGAATAGTGAAAA

GCCTCTCTAACGATGACATTAACAAAATAAGCGGCGATATGAAGGATAGTCTGAAG

GAAATGTCCCTCGAAGAAATATACTCATACGAGAAGTACGGAGAATTTATCACCCA

GGAAGGAATTAGTTTTTACAACGACATCTGTGGTAAGGTTAACTCTTTTATGAATCT

GTATTGTCAAAAGAATAAAGAAAATAAAAATCTTTATAAGCTCCAAAAGCTTCACA

AACAAATCTTGTGCATTGCGGATACGTCATACGAAGTACCTTACAAATTTGAAAGCG

ACGAAGAGGTGTATCAGTCAGTGAATGGGTTCCTTGACAATATTTCTAGCAAACATA

TTGTGGAGCGACTTCGAAAGATCGGTGATAATTACAATGGCTATAATTTGGATAAAA

TTTACATAGTTAGTAAGTTTTATGAATCCGTCTCACAAAAGACGTACCGAGATTGGG

AGACCATCAACACTGCTCTGGAGATTCATTACAATAATATATTGCCTGGGAATGGGA

AGTCAAAGGCCGACAAGGTTAAAAAAGCCGTAAAAAACGATCTTCAAAAGTCCATT

ACCGAGATAAATGAACTTGTATCCAACTATAAGTTGTGCTCTGACGATAATATTAAA

GCAGAAACGTATATCCACGAAATAAGTCACATCCTGAACAACTTCGAAGCTCAAGA

GCTCAAGTATAATCCTGAAATTCATCTCGTCGAAAGCGAGCTGAAAGCATCCGAGTT

GAAGAATGTGCTTGATGTGATCATGAACGCATTCCATTGGTGCAGTGTGTTCATGAC

CGAAGAACTTGTAGACAAAGACAACAACTTCTACGCTGAATTGGAAGAGATTTACG

ATGAAATTTACCCCGTGATATCCCTCTATAATCTGGTAAGAAATTACGTCACGCAAA

AACCATACAGTACCAAGAAAATAAAGCTCAACTTTGGTATTCCGACGTTGGCAGAT

GGGTGGAGTAAGAGCAAGGAGTATTCTAACAATGCAATCATCCTCATGCGCGACAA

TTTGTATTATCTGGGGATCTTCAACGCGAAAAATAAGCCCGACAAAAAGATAATAG

AAGGCAATACGTCCGAGAACAAAGGGGACTATAAGAAAATGATTTATAACCTTCTT

CCAGGACCCAACAAGATGATCCCAAAGGTTTTCTTGAGTTCAAAAACCGGCGTAGA

AACTTATAAACCGTCCGCCTACATTCTGGAAGGGTACAAGCAAAACAAGCACATTA

AGTCATCTAAGGATTTCGACATTACTTTTTGTCATGATTTGATAGACTACTTCAAAA A

TTGTATAGCGATACATCCGGAATGGAAAAATTTTGGGTTCGATTTTTCCGACACAAG TACTTATGAAGACATCTCAGGGTTTTATAGGGAAGTTGAACTGCAAGGTTACAAAAT

AGACTGGACTTATATTAGTGAGAAGGACATTGATTTGCTCCAGGAAAAGGGTCAATT

GTATCTGTTCCAGATATATAACAAGGATTTCTCTAAAAAATCTACAGGTAACGACAA

TCTCCACACGATGTACCTCAAGAATCTCTTCAGCGAAGAGAATTTGAAGGATATCGT

ACTTAAGCTCAATGGAGAAGCGGAAATATTCTTCAGAAAGTCCAGCATTAAGAATC

CTATAATTCACAAGAAAGGGTCAATTCTCGTAAACCGGACTTATGAGGCCGAAGAA

AAAGATCAGTTTGGTAACATTCAGATTGTACGGAAAAACATTCCCGAGAACATCTAT

CAAGAACTGTATAAATACTTTAATGATAAATCCGACAAGGAACTTTCTGACGAGGCT

GCAAAATTGAAGAACGTAGTGGGACACCATGAGGCCGCAACCAATATAGTAAAGGA

TTACAGATACACTTATGATAAGTATTTCCTCCATATGCCGATCACGATTAATTTCAA G

GCGAATAAAACCGGCTTCATTAACGATCGCATTTTGCAATATATTGCGAAGGAAAA

GGATTTGCACGTGATAGGTATAGACCGGGGTGAACGAAACTTGATTTACGTCTCTGT

GATCGACACATGCGGAAATATAGTTGAACAGAAGTCCTTTAATATTGTGAATGGTTA

CGACTACCAGATAAAATTGAAGCAACAGGAGGGCGCAAGACAGATAGCTCGCAAA

GAGTGGAAGGAAATCGGCAAGATCAAAGAAATAAAGGAGGGTTATCTTTCCCTGGT

AATTCATGAAATTAGCAAGATGGTTATTAAGTATAATGCTATAATAGCTATGGAGGA

CCTTTCCTATGGGTTCAAGAAAGGTCGCTTCAAAGTGGAGCGACAAGTGTATCAAAA

GTTCGAGACTATGTTGATAAATAAATTGAATTATTTGGTTTTTAAAGACATTTCAAT A

ACTGAGAACGGGGGTCTCTTGAAGGGGTACCAATTGACTTATATTCCGGACAAGTTG

AAGAATGTCGGACACCAGTGTGGTTGCATTTTCTACGTGCCTGCCGCTTACACCTCA

AAAATCGATCCGACCACTGGTTTTGTAAATATATTTAAATTCAAAGATCTCACCGTT

GATGCCAAACGGGAGTTTATCAAAAAATTCGATTCCATTCGCTACGACTCTGAGAAA

AACCTTTTTTGTTTCACGTTCGATTATAACAACTTTATAACCCAAAATACTGTAATG T

CCAAGTCAAGTTGGTCTGTCTATACTTACGGAGTAAGGATCAAGCGCCGCTTCGTTA

ATGGGAGATTCTCAAACGAGTCTGATACCATAGACATAACTAAAGACATGGAAAAA

ACCCTGGAAATGACGGACATCAATTGGCGAGACGGGCATGATCTTCGACAGGACAT

AATAGATTACGAAATTGTTCAACACATTTTCGAGATATTTCGACTTACGGTTCAGAT

GAGGAATTCCCTTTCCGAATTGGAAGACCGGGATTATGATCGACTTATATCTCCCGT

GCTCAATGAAAACAATATTTTTTATGATTCAGCGAAAGCTGGGGACGCGCTGCCAAA

AGATGCCGATGCCAATGGAGCATACTGTATCGCCCTGAAGGGTTTGTATGAGATTAA

GCAAATTACTGAAAACTGGAAGGAAGATGGCAAGTTTTCTAGAGATAAGCTTAAGA

TTAGCAATAAGGACTGGTTTGACTTCATTCAAAATAAAAGGTATCTT

[0079] SEQ ID NO: 42

ATGAATAATGGAACAAATAATTTTCAAAATTTTATTGGTATCAGTTCATTGCAAAAG

ACTTTGAGAAATGCTTTGATCCCGACTGAGACCACACAGCAGTTCATCGTCAAAAAT GGCATAATCAAGGAAGACGAACTTAGGGGTGAGAATAGACAAATATTGAAGGACAT

CATGGATGACTATTATAGGGGGTTCATTTCCGAAACGCTCAGTAGTATTGATGACAT

TGACTGGACTAGTCTTTTCGAGAAAATGGAAATTCAGCTTAAGAACGGGGACAATA

AAGACACGCTGATCAAGGAGCAAACGGAATATAGGAAGGCGATCCATAAAAAATTC

GCGAATGATGATCGGTTTAAAAACATGTTTAGTGCCAAGTTGATCAGCGACATACTG

CCCGAATTCGTGATCCACAACAATAATTACAGCGCCTCCGAAAAGGAGGAAAAAAC

TCAGGTCATTAAATTGTTTAGCCGATTCGCAACGAGTTTCAAAGATTATTTTAAGAA

CCGGGCCAACTGTTTTTCAGCGGATGATATTAGCTCCAGCAGCTGCCATCGCATAGT

AAATGATAACGCTGAAATCTTTTTTAGCAACGCACTTGTCTACCGGAGGATTGTAAA

ATCACTGTCAAATGATGACATTAACAAAATATCTGGAGATATGAAGGACTCACTCA

AAGAAATGAGCCTGGAAGAAATATATTCATACGAAAAATACGGGGAGTTTATTACC

CAGGAAGGTATCAGTTTTTATAATGATATATGTGGAAAAGTTAATTCATTTATGAAT

CTTTACTGT C AA AAAAAT AAGGAGA AC AAGAATTT GT AC AAGCTCC AAAAACTT C A

TAAACAGATTCTGTGCATCGCAGACACAAGTTATGAGGTACCGTACAAATTTGAGA

GCGACGAAGAAGTTTATCAGAGTGTGAATGGTTTCCTGGACAATATCTCTTCTAAAC

ACATTGTTGAGAGGCTTAGGAAGATCGGTGATAATTATAACGGCTATAATCTGGACA

AAATTTATATTGTATCAAAGTTTTATGAATCAGTCTCTCAAAAGACGTATCGGGATT

GGGAAACAATTAACACGGCTCTGGAGATCCACTACAATAACATTCTGCCCGGCAAC

GGGAAGAGCAAAGCTGATAAGGTCAAGAAGGCAGTCAAGAACGACCTTCAGAAGA

GCATAACAGAAATTAACGAATTGGTCAGTAACTACAAACTGTGTAGTGATGACAAC

ATAAAAGCCGAAACATACATCCATGAAATAAGCCATATCCTGAATAACTTCGAAGC

CCAAGAACTTAAATACAATCCCGAGATTCATCTTGTCGAATCAGAACTCAAGGCGTC

CGAGCTCAAAAATGTCCTTGACGTGATAATGAATGCCTTCCACTGGTGCAGCGTATT

CATGACGGAGGAGTTGGTAGATAAAGACAACAACTTTTATGCCGAATTGGAAGAGA

TTTATGATGAGATTTACCCCGTTATTTCTCTGTACAACTTGGTTCGAAACTACGTAA C

ACAAAAACCATACTCAACCAAAAAGATCAAACTCAATTTTGGCATACCTACATTGGC

TGATGGTTGGTCCAAGTCAAAGGAATATAGCAATAATGCAATAATTCTCATGCGAG

ATAACTTGTATTATTTGGGGATCTTTAACGCTAAGAACAAACCAGATAAAAAGATAA

TCGAGGGGAACACAAGTGAGAACAAGGGTGATTACAAAAAAATGATTTACAATCTG

CTTCCTGGGCCTAACAAAATGATTCCGAAGGTGTTTCTTAGCTCTAAAACTGGAGTG

GAGACGTATAAGCCTTCCGCGTACATTCTCGAAGGCTACAAGCAAAATAAGCATAT

CAAGTCCAGTAAGGACTTCGACATCACTTTTTGCCACGATCTCATCGATTACTTTAA

GAACTGTATCGCAATACACCCCGAGTGGAAAAACTTTGGTTTTGATTTTTCAGACAC

TAGTACCTACGAGGACATTTCCGGCTTCTATCGAGAAGTCGAACTCCAGGGCTACAA

AATCGATTGGACGTACATTTCTGAGAAGGACATCGACTTGCTCCAAGAGAAAGGTC AACTTTACCTCTTCCAAATTTACAATAAAGACTTTTCAAAGAAGAGCACCGGTAATG

ACAACTTGCATACCATGTATCTGAAGAACCTGTTTTCTGAGGAGAACCTCAAGGATA

TTGTATTGAAGTTGAATGGCGAAGCAGAAATATTTTTCCGAAAGTCATCTATCAAGA

ACCCCATTATACACAAAAAAGGCTCTATCCTGGTGAACCGGACTTACGAGGCAGAG

GAGAAGGATCAATTCGGAAACATACAGATAGTCCGCAAAAACATCCCTGAGAATAT

CTATCAGGAACTCTATAAGTACTTCAATGATAAATCAGACAAGGAGCTTAGCGACG

AAGCAGCTAAACTTAAAAACGTGGTTGGCCATCACGAGGCCGCTACCAACATAGTC

AAAGACTACCGCTATACTTATGACAAGTACTTTTTGCACATGCCCATAACAATTAAT

TTCAAAGCTAACAAAACAGGGTTTATAAATGACAGAATCCTCCAATACATCGCCAA

AGAGAAGGACCTCCATGTAATCGGGATTGATAGAGGCGAACGGAACTTGATTTACG

TTAGTGTCATTGATACCTGTGGTAACATTGTCGAACAAAAGTCATTCAACATAGTCA

ATGGATATGATTATCAGATAAAACTCAAGCAACAAGAAGGCGCGAGGCAGATTGCC

AGGAAGGAATGGAAAGAAATCGGGAAGATCAAGGAGATCAAGGAGGGTTACCTGT

CCTTGGTGATACACGAGATTTCAAAAATGGTTATAAAATACAATGCCATTATCGCGA

TGGAGGATTTGTCTTATGGATTTAAGAAGGGGAGGTTCAAAGTCGAACGACAAGTC

TATCAGAAGTTTGAAACAATGCTCATTAACAAGCTCAATTACCTTGTTTTCAAGGAT

ATAAGCATCACTGAAAACGGCGGACTCCTTAAGGGATATCAGCTGACTTATATCCCC

GACAAGCTCAAGAACGTAGGGCACCAATGCGGATGCATCTTTTACGTGCCTGCAGC

ATATACTTCAAAAATTGATCCGACTACTGGCTTTGTTAACATTTTCAAGTTCAAGGA T

CTGACGGTAGACGCTAAGAGAGAATTCATAAAAAAGTTTGACAGCATCAGGTACGA

TAGTGAAAAGAACCTTTTTTGTTTTACCTTTGACTACAATAATTTTATTACGCAAAA T

ACAGTTATGAGCAAATCAAGTTGGAGCGTTTACACATATGGCGTTCGGATCAAGCGC

AGATTCGTCAATGGTCGCTTCTCAAATGAGAGCGATACAATCGATATAACGAAGGA

TATGGAGAAGACGCTTGAGATGACAGATATCAACTGGCGGGACGGACATGACCTTA

GACAAGACATAATCGATTACGAAATAGTACAGCATATCTTTGAGATTTTTAGGCTTA

CAGTTCAGATGCGGAACTCTCTTTCCGAACTGGAGGACCGGGATTATGATCGGTTGA

TCTCCCCAGTACTGAACGAAAATAATATCTTTTACGATAGCGCGAAGGCTGGTGATG

CACTCCCAAAAGACGCTGATGCGAACGGAGCTTATTGCATAGCCCTTAAAGGGCTTT

ACGAGATTAAACAAATAACAGAAAATTGGAAGGAAGATGGCAAATTTTCCCGCGAC

AAGTTGAAGATTAGTAACAAAGACTGGTTCGACTTCATTCAGAATAAACGCTACCTC

[0080] Nucleic acid-guided nucleases can encompass a native sequence, an engineered sequence, or engineered nucleotide sequences of synthetized variants. Non-limiting examples of types of engineering that can be done to obtain a non-naturally occurring nuclease system are as follows. Engineering can include codon optimization to facilitate expression or improve expression in a host cell, such as a heterologous host cell. Engineering can reduce the size or molecular weight of the nuclease in order to facilitate expression or delivery. Engineering can alter PAM selection in order to change PAM specificity or to broaden the range of recognized PAMs. Engineering can alter, increase, or decrease stability, processivity, specificity, or efficiency of a targetable nuclease system. Engineering can alter, increase, or decrease protein stability. Engineering can alter, increase, or decrease processivity of nucleic acid scanning. Engineering can alter, increase, or decrease target sequence specificity. Engineering can alter, increase, or decrease nuclease activity. Engineering can alter, increase, or decrease editing efficiency. Engineering can alter, increase, or decrease transformation efficiency. Engineering can alter, increase, or decrease nuclease or guide nucleic acid expression. As used herein, a non- naturally occurring nucleic acid sequence can be an engineered sequence or engineered nucleotide sequences of synthetized variants. Such non-naturally occurring nucleic acid sequences can be amplified, cloned, assembled, synthesized, generated from synthesized oligonucleotides or dNTPs, or otherwise obtained using methods known by those skilled in the art. In certain embodiments, examples of non-naturally occurring nucleic acid-guided nucleases disclosed herein can include those nucleic acid-guided nucleases with engineered polypeptide sequences ( e.g SEQ ID NOs:2-4) and those nucleotide sequences of synthetized variants (e.g., SEQ ID NOs: 43-63)

[0081] SEQ ID NO: 2

MGHHHHHHS S GVDLGTENLYFQSPAAKKKKLDGS VDMNN GTNNF QNFIGIS SLQKTLR

NALIPTETTQQFIVKNGIIKEDELRGENRQILKDIMDDYYRGFISETLSSIDDIDWT SLFEK

MEIQLKNGDNKDTLIKEQTEYRKAIHKKFANDDRFKNMFSAKLISDILPEFVIHNNN YSA

SEKEEKTQVIKLFSRFATSFKDYFKNRANCFSADDISSSSCHRIVNDNAEIFFSNAL VYRRI

VKSLSNDDINKISGDMKDSLKEMSLEEIYSYEKYGEFITQEGISFYNDICGKVNSFM NLY

CQKNKENKNLYKLQKLHKQILCIADTS YEVPYKFESDEEVYQSVN GFLDNIS SKHIVERL

RKIGDNYNGYNLDKIYIVSKFYESVSQKTYRDWETINTALEIHYNNILPGNGKSKAD KV

KKAVKNDLQKSITEINELVSNYKLCSDDNIKAETYIHEISHILNNFEAQELKYNPEI HLVE

SELKASELKNVLDVIMNAFHWCSVFMTEELVDKDNNFYAELEEIYDEIYPVISLYNL VR

NYVTQKPYSTKKIKLNFGIPTLADGWSKSKEYSNNAIILMRDNLYYLGIFNAKNKPD KKI

IEGNTSENKGDYKKMIYNLLPGPNKMIPKVFLSSKTGVETYKPSAYILEGYKQNKHI KSS

KDFDITFCHDLIDYFKNCIAIHPEWKNFGFDFSDTSTYEDISGFYREVELQGYKIDW TYIS

EKDIDLLQEKGQLYLFQIYNKDFSKKSTGNDNLHTMYLKNLFSEENLKDIVLKLNGE AEI

FFRKSSIKNPIIHKKGSILVNRTYEAEEKDQFGNIQIVRKNIPENIYQELYKYFNDK SDKEL

SDEAAKLKNVVGHHEAATNIVKDYRYTYDKYFLHMPITINFKANKTGFINDRILQYI AK

EKDLHVIGIDRGERNLIYVSVIDTCGNIVEQKSFNIVNGYDYQIKLKQQEGARQIAR KEW

KEIGKIKEIKEGYLSLVIHEISKMVIKYNAIIAMEDLSYGFKKGRFKVERQVYQKFE TMLI NKLNYLVFKDISITENGGLLKGYQLTYIPDKLKNVGHQCGCIFYVPAAYTSKIDPTTGFV

NIFKFKDLTVDAKREFIKKFDSIRYDSEKNLFCFTFDYNNFITQNTVMSKSSWSVYT YGV

RIKRRFVNGRFSNESDTIDITKDMEKTLEMTDINWRDGHDLRQDIIDYEIVQHIFEI FRLTV

QMRNSLSELEDRDYDRLISPVLNENNIFYDSAKAGDALPKDADANGAYCIALKGLYE IK

QITENWKEDGKFSRDKLKISNKDWFDFIQNKRYLKRPAATKKAGQAKKKKASGSGAG S

PKKKRKVEDPKKKRKVIPG*

[0082] SEQ ID NO:3

SPAAKKKKLDGSVDMNNGTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGIIKE DELR

GENRQILKDIMDDYYRGFISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKEQTE YRK

AIHKKFANDDRFKNMFSAKLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSF KDYF

KNRANCFSADDISSSSCHRIVNDNAEIFFSNALVYRRIVKSLSNDDINKISGDMKDS LKEM

SLEEIYSYEKYGEFITQEGISFYNDICGKVNSFMNLYCQKNKENKNLYKLQKLHKQI LCI

ADTSYEVPYKFESDEEVYQSVNGFLDNISSKHIVERLRKIGDNYNGYNLDKIYIVSK FYE

SVSQKTYRDWETINTALEIHYNNILPGNGKSKADKVKKAVKNDLQKSITEINELVSN YK

LCSDDNIKAETYIHEISHILNNFEAQELKYNPEIHLVESELKASELKNVLDVIMNAF HWCS

VFMTEELVDKDNNFYAELEEIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFGIPT LAD

GWSKSKEYSNNAIILMRDNLYYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLLP GP

NKMIPKVFLSSKTGVETYKPSAYILEGYKQNKHIKSSKDFDITFCHDLIDYFKNCIA IHPE

WKNFGFDFSDTSTYEDISGFYREVELQGYKIDWTYISEKDIDLLQEKGQLYLFQIYN KDF

SKKSTGNDNLHTMYLKNLFSEENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILV NRTY

EAEEKDQFGNIQIVRKNIPENIYQELYKYFNDKSDKELSDEAAKLKNVVGHHEAATN IV

KDYRYTYDKYFLHMPITINFKANKTGFINDRILQYIAKEKDLHVIGIDRGERNLIYV SVID

TCGNIVEQKSFNIVNGYDYQIKLKQQEGARQIARKEWKEIGKIKEIKEGYLSLVIHE ISKM

VIKYNAIIAMEDLSYGFKKGRFKVERQVYQKFETMLINKLNYLVFKDISITENGGLL KGY

QLTYIPDKLKNVGHQCGCIFYVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKF DSIR

YDSEKNLFCFTFDYNNFITQNTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDTIDIT KDM

EKTLEMTDINWRDGHDLRQDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLIS PVLN

ENNIFYDSAKAGDALPKDADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISN KD

WFDFIQNKRYLKRPAATKKAGQAKKKKASGSGAGSPKKKRKVEDPKKKRKVIPG*

[0083] SEQ ID NO: 4

PAAKKKKLDGSVDMNNGTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGIIKED ELRG ENRQILKDIMDDYYRGFISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKEQTEYRKA I HKKFANDDRFKNMFSAKLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSFKDYFK NRANCFSADDISSSSCHRIVNDNAEIFFSNALVYRRIVKSLSNDDINKISGDMKDSLKEM S LEEIY S YEKY GEFITQEGISFYNDICGKVNSFMNLYCQKNKENKNL YKLQKLHKQILCIA DT S YEVP YKFESDEEV Y Q S VN GFLDNIS SKHIVERLRKIGDN YN GYNLDKI YI VSKF YES

VSQKTYRDWETINTALEIHYNNILPGNGKSKADKVKKAVKNDLQKSITEINELVSNY KL

CSDDNIKAETYIHEISHILNNFEAQELKYNPEIHLVESELKASELKNVLDVIMNAFH WCSV

FMTEELVDKDNNFYAELEEIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFGIPTL ADG

WSKSKEYSNNAIILMRDNLYYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLLPG PN

KMIPKVFLSSKTGVETYKPSAYILEGYKQNKHIKSSKDFDITFCHDLIDYFKNCIAI HPEW

KNFGFDFSDTSTYEDISGFYREVELQGYKIDWTYISEKDIDLLQEKGQLYLFQIYNK DFSK

KSTGNDNLHTMYLKNLFSEENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILVNR TYEA

EEKDQFGNIQIVRKNIPENIYQELYKYFNDKSDKELSDEAAKLKNVVGHHEAATNIV KD

YRYTYDKYFLHMPITINFKANKTGFINDRILQYIAKEKDLHVIGIDRGERNLIYVSV IDTC

GNIVEQKSFNIVNGYDYQIKLKQQEGARQIARKEWKEIGKIKEIKEGYLSLVIHEIS KMVI

KYNAIIAMEDLSYGFKKGRFKVERQVYQKFETMLINKLNYLVFKDISITENGGLLKG YQ

LTYIPDKLKNVGHQCGCIFYVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKFD SIRY

DSEKNLFCFTFDYNNFITQNTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDTIDITK DME

KTLEMTDINWRDGHDLRQDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLISP VLNE

NNIFYDSAKAGDALPKDADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISNK D

WFDFIQNKRYLKRPAATKKAGQAKKKKASGSGAGSPKKKRKVEDPKKKRKVIPG*

[0084] SEQ ID NO: 109:

SMSRRRKANPTKLSENAKKLAKEVENASGSGAGSKRPAATKKAGQAKKKKASGSGAG

SPAAKKKKLDGSVDASGSGAGSPKKKRKVEDASGSGAGSPKKKRKVASGSGAGSMNN

GTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGIIKEDELRGENRQILKDIMDD YYRGF

ISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKEQTEYRKAIHKKFANDDRFKNM FSA

KLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSFKDYFKNRANCFSADDISS SSCHR

IVNDNAEIFFSNALVYRRIVKSLSNDDINKISGDMKDSLKEMSLEEIYSYEKYGEFI TQEGI

SFYNDICGKVNSFMNLYCQKNKENKNLYKLQKLHKQILCIADTSYEVPYKFESDEEV YQ

SVNGFLDNISSKHIVERLRKIGDNYNGYNLDKIYIVSKFYESVSQKTYRDWETINTA LEIH

YNNILPGNGKSKADKVKKAVKNDLQKSITEINELVSNYKLCSDDNIKAETYIHEISH ILN

NFEAQELKYNPEIHLVESELKASELKNVLDVIMNAFHWCSVFMTEELVDKDNNFYAE LE

EIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFGIPTLADGWSKSKEYSNNAIILM RDNL

YYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLLPGPNKMIPKVFLSSKTGVETY KPS

AYILEGYKQNKHIKS SKDFDITFCHDLID YFKN CIAIHPEWKNF GFDF SDTS T YEDIS GF Y

REVELQGYKIDWTYISEKDIDLLQEKGQLYLFQIYNKDFSKKSTGNDNLHTMYLKNL FS

EENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILVNRTYEAEEKDQFGNIQIVRK NIPENI

YQELYKYFNDKSDKELSDEAAKLKNVVGHHEAATNIVKDYRYTYDKYFLHMPITINF K

ANKTGFINDRILQYIAKEKDLHVIGIDRGERNLIYVSVIDTCGNIVEQKSFNIVNGY DYQI KLKQQEGARQIARKEWKEIGKIKEIKEGYLSLVIHEISKMVIKYNAIIAMEDLSYGFKKG

RFKVERQV YQKFETMLINKLNYL VFKDISITEN GGLLKGY QLTYIPDKLKNV GHQCGCIF

YVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKFDSIRYDSEKNLFCFTFDYNN FITQ

NTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDTIDITKDMEKTLEMTDINWRDGHDL R

QDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLISPVLNENNIFYDSAKAGDA LPKD

ADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISNKDWFDFIQNKRYL

[0085] SEQ ID NO: 110:

MSRRRKANPTKLSENAKKLAKEVENASGSGAGSKRPAATKKAGQAKKKKASGSGAGS

PAAKKKKLDGSVDASGSGAGSPKKKRKVEDASGSGAGSPKKKRKVASGSGAGSMNNG

TNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGIIKEDELRGENRQILKDIMDDY YRGFI

SETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKEQTEYRKAIHKKFANDDRFKNMF SAK

LISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSFKDYFKNRANCFSADDISSS SCHRI

VNDNAEIFFSNALVYRRIVKSLSNDDINKISGDMKDSLKEMSLEEIYSYEKYGEFIT QEGI

SFYNDICGKVNSFMNLYCQKNKENKNLYKLQKLHKQILCIADTSYEVPYKFESDEEV YQ

SVNGFLDNISSKHIVERLRKIGDNYNGYNLDKIYIVSKFYESVSQKTYRDWETINTA LEIH

YNNILPGNGKSKADKVKKAVKNDLQKSITEINELVSNYKLCSDDNIKAETYIHEISH ILN

NFEAQELKYNPEIHLVESELKASELKNVLDVIMNAFHWCSVFMTEELVDKDNNFYAE LE

EIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFGIPTLADGWSKSKEYSNNAIILM RDNL

YYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLLPGPNKMIPKVFLSSKTGVETY KPS

AYILEGYKQNKHIKS SKDFDITFCHDLID YFKN CIAIHPEWKNF GFDF SDTS T YEDIS GF Y

REVELQGYKIDWTYISEKDIDLLQEKGQLYLFQIYNKDFSKKSTGNDNLHTMYLKNL FS

EENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILVNRTYEAEEKDQFGNIQIVRK NIPENI

YQELYKYFNDKSDKELSDEAAKLKNVVGHHEAATNIVKDYRYTYDKYFLHMPITINF K

ANKTGFINDRILQYIAKEKDLHVIGIDRGERNLIYVSVIDTCGNIVEQKSFNIVNGY DYQI

KLKQQEGARQIARKEWKEIGKIKEIKEGYLSLVIHEISKMVIKYNAIIAMEDLSYGF KKG

RFKVERQV YQKFETMLINKLNYL VFKDISITEN GGLLKGY QLTYIPDKLKNV GHQCGCIF

YVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKFDSIRYDSEKNLFCFTFDYNN FITQ

NTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDTIDITKDMEKTLEMTDINWRDGHDL R

QDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLISPVLNENNIFYDSAKAGDA LPKD

ADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISNKDWFDFIQNKRYL

[0086] SEQ ID NO: 111

GHHHHHHSSGVDLGTENLYFQSMSRRRKANPTKLSENAKKLAKEVENASGSGAGSKR P

AATKKAGQAKKKKASGSGAGSPAAKKKKLDGSVDASGSGAGSPKKKRKVEDASGSGA

GSPKKKRKVASGSGAGSMNNGTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKNGI IKED

ELRGENRQILKDIMDDYYRGFISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLIKE QTEY RKAIHKKFANDDRFKNMFSAKLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRFATSFK D

YFKNRANCFSADDISSSSCHRIVNDNAEIFFSNALVYRRIVKSLSNDDINKISGDMK DSLK

EMSLEEIYSYEKYGEFITQEGISFYNDICGKVNSFMNLYCQKNKENKNLYKLQKLHK QIL

CIADTSYEVPYKFESDEEVYQSVNGFLDNISSKHIVERLRKIGDNYNGYNLDKIYIV SKFY

ESVSQKTYRDWETINTALEIHYNNILPGNGKSKADKVKKAVKNDLQKSITEINELVS NY

KLCSDDNIKAETYIHEISHILNNFEAQELKYNPEIHLVESELKASELKNVLDVIMNA FHW

CSVFMTEELVDKDNNFYAELEEIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFGI PTLA

DGWSKSKEYSNNAIILMRDNLYYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYNLL PG

PNKMIPKVFL S SKT GVET YKP S A YILEGYKQNKHIKS SKDFDITFCHDLID YFKNCIAIHPE

WKNFGFDFSDTSTYEDISGFYREVELQGYKIDWTYISEKDIDLLQEKGQLYLFQIYN KDF

SKKSTGNDNLHTMYLKNLFSEENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILV NRTY

EAEEKDQFGNIQIVRKNIPENIYQELYKYFNDKSDKELSDEAAKLKNVVGHHEAATN IV

KDYRYTYDKYFLHMPITINFKANKTGFINDRILQYIAKEKDLHVIGIDRGERNLIYV SVID

TCGNIVEQKSFNIVNGYDYQIKLKQQEGARQIARKEWKEIGKIKEIKEGYLSLVIHE ISKM

VIKYNAIIAMEDLSYGFKKGRFKVERQVYQKFETMLINKLNYLVFKDISITENGGLL KGY

QLTYIPDKLKNVGHQCGCIFYVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKF DSIR

YDSEKNLFCFTFDYNNFITQNTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDTIDIT KDM

EKTLEMTDINWRDGHDLRQDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDRLIS PVLN

ENNIFYDSAKAGDALPKDADANGAYCIALKGLYEIKQITENWKEDGKFSRDKLKISN KD

WFDFIQNKRYL*

[0087] SEQ ID NO: 112

MGHHHHHHSSGVDLGTENLYFQSMSRRRKANPTKLSENAKKLAKEVENASGSGAGSK

RPAATKKAGQAKKKKASGSGAGSPAAKKKKLDGSVDASGSGAGSPKKKRKVEDASGS

GAGSPKKKRKVASGSGAGSMNNGTNNFQNFIGISSLQKTLRNALIPTETTQQFIVKN GIIK

EDELRGENRQILKDIMDDYYRGFISETLSSIDDIDWTSLFEKMEIQLKNGDNKDTLI KEQT

EYRKAIHKKFANDDRFKNMFSAKLISDILPEFVIHNNNYSASEKEEKTQVIKLFSRF ATSF

KDYFKNRANCFSADDISSSSCHRIVNDNAEIFFSNALVYRRIVKSLSNDDINKISGD MKDS

LKEMSLEEIYSYEKYGEFITQEGISFYNDICGKVNSFMNLYCQKNKENKNLYKLQKL HK

QILCIADTSYEVPYKFESDEEVYQSVNGFLDNISSKHIVERLRKIGDNYNGYNLDKI YIVS

KFYESVSQKTYRDWETINTALEIHYNNILPGNGKSKADKVKKAVKNDLQKSITEINE LVS

NYKLCSDDNIKAETYIHEISHILNNFEAQELKYNPEIHLVESELKASELKNVLDVIM NAFH

WCSVFMTEELVDKDNNFYAELEEIYDEIYPVISLYNLVRNYVTQKPYSTKKIKLNFG IPT

LADGWSKSKEYSNNAIILMRDNLYYLGIFNAKNKPDKKIIEGNTSENKGDYKKMIYN LL

PGPNKMIPKVFLSSKTGVE TYKPSA YILEGYKQNKHIKS SKDFDITFCHDLID YFKNCIAI

HPEWKNFGFDFSDTSTYEDISGFYREVELQGYKIDWTYISEKDIDLLQEKGQLYLFQ IYN KDFSKKSTGNDNLHTMYLKNLFSEENLKDIVLKLNGEAEIFFRKSSIKNPIIHKKGSILV N

RTYEAEEKDQFGNIQIVRKNIPENIYQELYKYFNDKSDKELSDEAAKLKNVVGHHEA AT

NIVKDYRYTYDKYFLHMPITINFKANKTGFINDRILQYIAKEKDLHVIGIDRGERNL IYVS

VIDTCGNIVEQKSFNIVNGYDYQIKLKQQEGARQIARKEWKEIGKIKEIKEGYLSLV IHEI

SKMVIKYNAIIAMEDLSYGFKKGRFKVERQVYQKFETMLINKLNYLVFKDISITENG GLL

KGY QLTYIPDKLKNV GHQCGCIFYVPAAYTSKIDPTTGFVNIFKFKDLTVDAKREFIKKF

DSIRYDSEKNLFCFTFDYNNFITQNTVMSKSSWSVYTYGVRIKRRFVNGRFSNESDT IDIT

KDMEKTLEMTDINWRDGHDLRQDIIDYEIVQHIFEIFRLTVQMRNSLSELEDRDYDR LIS

PVLNENNIFYDSAKAGDALPKDADANGAYCIALKGLYEIKQITENWKEDGKFSRDKL KI

SNKD WFDF IQNKRYL *

[0088] SEQ ID NO: 43

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAACGGTACCAATAACTTCCAGAACTTCATCGGTATTTCTAGCCTGCAAAAGACCCT

GCGTAACGCGCTGATTCCGACCGAGACTACCCAGCAATTCATCGTGAAAAACGGTA

TCATTAAGGAAGATGAATTGCGCGGTGAGAATCGTCAGATTCTGAAAGATATCATG

GATGACTACTATCGCGGTTTCATTAGCGAAACCCTGTCGAGCATCGATGATATCGAT

TGGACGAGCCTCTTCGAGAAAATGGAAATTCAACTGAAAAATGGTGACAACAAAGA

TACCCTGATTAAAGAACAAACGGAATACCGCAAGGCAATCCATAAAAAGTTTGCGA

ATGACGACCGTTTTAAGAATATGTTCTCGGCCAAGCTGATTTCCGACATCCTGCCAG

AGTTCGTCATTCACAACAACAATTACAGCGCAAGCGAGAAAGAGGAAAAGACTCAG

GTCATTAAGCTGTTTAGCCGCTTTGCGACGTCCTTCAAAGACTACTTCAAGAATCGT

GCGAATTGCTTTAGCGCGGATGACATCTCTAGCTCTAGCTGTCACCGTATTGTTAAC

GACAATGCAGAGATTTTCTTCAGCAACGCCCTGGTGTATCGCCGTATTGTCAAGTCT

CTGAGCAACGACGACATTAACAAGATCAGCGGCGACATGAAAGACAGCCTGAAAG

AAATGTCTCTGGAAGAAATCTACAGCTACGAGAAATATGGTGAGTTTATCACCCAA

GAGGGCATTAGCTTCTACAATGATATCTGTGGTAAGGTTAATAGCTTTATGAATCTG

TACTGCCAGAAGAATAAAGAAAACAAGAACTTGTACAAGCTGCAAAAGCTGCATAA

GCAAATTCTGTGCATCGCCGATACTAGCTATGAAGTTCCGTACAAGTTCGAGTCTGA

TGAAGAGGTGTATCAGTCAGTCAACGGTTTTCTGGATAACATCAGCAGCAAGCACAT

CGTCGAGCGCCTGCGCAAGATTGGTGACAACTACAATGGTTATAACCTGGACAAGA

TCTATATCGTGTCGAAGTTTTACGAGAGCGTGTCCCAGAAAACGTACCGTGATTGGG

AAACGATTAACACGGCCTTGGAAATTCACTATAACAATATCCTGCCGGGCAACGGC

AAGAGCAAAGCTGACAAAGTCAAAAAAGCTGTGAAAAACGATCTGCAAAAGTCCAT

CACCGAGATCAACGAACTGGTTAGCAACTATAAGCTGTGTAGCGACGACAACATTA AAGCTGAAACGTATATCCACGAAATCAGCCACATCCTGAATAACTTTGAGGCACAA

GAACTGAAATACAATCCTGAGATCCATCTGGTAGAGAGCGAGCTGAAGGCAAGCGA

GTTGAAAAACGTTCTCGACGTTATCATGAATGCTTTCCACTGGTGTAGCGTGTTTAT G

ACCGAAGAACTGGTTGACAAAGATAACAATTTCTATGCAGAGCTGGAAGAAATCTA

TGATGAAATCTACCCGGTCATCAGCCTGTATAACCTGGTTCGTAACTACGTGACGCA

GAAGCCGTACAGCACCAAAAAGATCAAGCTGAACTTCGGTATTCCGACCTTGGCGG

ACGGTTGGAGCAAATCCAAAGAATACTCCAATAATGCGATTATTCTGATGCGTGATA

ATCTGTACTATCTGGGTATCTTCAATGCGAAGAACAAGCCAGATAAAAAGATTATTG

AAGGCAACACCAGCGAGAATAAAGGCGACTACAAGAAAATGATCTACAACTTATTG

CCGGGTCCGAACAAGATGATCCCGAAAGTTTTTCTGAGCAGCAAGACCGGCGTTGA

AACCTATAAGCCGAGCGCGTACATTTTAGAGGGCTATAAACAAAACAAGCACATCA

AGAGCAGCAAAGATTTTGATATTACGTTCTGCCACGACCTGATCGACTATTTCAAGA

ATTGTATTGCGATTCACCCTGAGTGGAAGAACTTCGGTTTTGACTTTTCCGATACCT C

CACCTATGAAGATATTAGCGGTTTTTACCGTGAAGTCGAGTTGCAGGGTTATAAGAT

TGATTGGACTTACATTTCCGAGAAAGACATCGACCTGTTGCAAGAGAAAGGTCAGCT

GTACCTGTTTCAGATCTATAACAAAGATTTCAGCAAAAAGTCGACGGGCAATGATA

ATCTGCACACCATGTATCTGAAAAACCTGTTTAGCGAAGAGAACCTGAAAGACATT

GTTCTTAAGCTGAATGGTGAGGCCGAGATCTTCTTCCGTAAAAGCTCCATTAAGAAC

CCGATTATCCACAAAAAGGGCTCTATTCTGGTTAACCGCACGTACGAAGCGGAAGA

GAAAGATCAATTTGGTAACATCCAGATCGTGCGTAAGAATATCCCGGAGAACATTT

ACCAAGAACTGTATAAGTATTTCAATGACAAGAGCGATAAAGAATTGAGCGATGAA

GCGGCAAAGCTGAAAAACGTCGTTGGCCACCACGAAGCCGCGACGAATATCGTGAA

AGATTATCGTTACACCTACGACAAGTACTTTCTGCACATGCCGATCACCATCAATTT

CAAAGCGAATAAAACGGGTTTTATCAATGACCGTATCCTGCAGTACATTGCGAAAG

AAAAAGATTTACACGTGATTGGTATTGATCGCGGCGAGCGCAATCTGATTTACGTCA

GCGTTATCGACACGTGCGGCAATATTGTGGAGCAGAAAAGCTTCAATATCGTCAATG

GTTACGACTACCAGATCAAACTGAAGCAACAAGAGGGCGCCCGCCAGATTGCGCGT

AAAGAGTGGAAAGAAATCGGTAAGATTAAAGAAATCAAGGAAGGCTACCTGTCCCT

GGTGATCCATGAAATCAGCAAAATGGTGATCAAGTACAACGCTATCATTGCGATGG

AAGATCTGAGCTACGGTTTTAAAAAGGGTCGCTTCAAAGTTGAGCGTCAAGTGTATC

AGAAATTTGAGACTATGCTGATTAACAAGTTGAACTATCTGGTTTTTAAAGACATCA

GCATTACCGAGAATGGTGGCCTGCTGAAGGGTTATCAACTGACCTATATTCCTGACA

AGTTGAAAAATGTTGGTCATCAGTGTGGTTGCATTTTCTACGTACCGGCAGCGTACA

CGAGCAAGATTGACCCGACCACGGGTTTCGTTAACATTTTCAAGTTTAAAGATTTGA

CCGTGGACGCCAAGCGTGAGTTCATTAAAAAGTTCGACAGCATCAGATACGACTCT GAGAAGAATCTGTTCTGCTTTACGTTCGACTACAATAACTTCATTACCCAAAATACC

GTTATGAGCAAAAGCTCCTGGAGCGTGTACACGTACGGCGTCCGTATCAAGCGTCGT

TTTGTGAATGGTCGCTTTTCCAACGAATCTGACACCATTGACATTACCAAAGATATG

GAAAAGACCCTTGAGATGACCGACATTAATTGGCGTGATGGCCATGACTTGCGCCA

AGACATTATCGACTACGAAATTGTTCAGCACATCTTTGAGATTTTTCGTCTGACGGT C

CAGATGCGCAACTCGCTGAGCGAGTTGGAAGATCGTGACTATGACCGTCTGATTAGC

CCGGTGCTGAATGAAAACAATATCTTCTATGATAGCGCAAAGGCCGGTGACGCGCT

GCCGAAAGATGCGGATGCTAACGGTGCATACTGCATTGCACTGAAGGGTCTGTACG

AAATCAAACAGATCACCGAGAATTGGAAAGAGGATGGTAAGTTTAGCCGTGATAAG

CTGAAGATTAGCAATAAAGACTGGTTCGACTTTATTCAAAACAAGCGCTATCTGAAA

CGTCCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTA

GCGGCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACG

TAAGGTTATTCCGGGCTAA

[0089] SEQ ID NO: 44

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGAACAAATAATTTTCAGAACTTTATTGGGATCAGTTCGCTTCAGAAAACGCT

TCGTAATGCTCTGATTCCCACAGAAACCACTCAGCAGTTTATCGTAAAGAATGGCAT

TATCAAGGAGGATGAATTACGCGGCGAGAACCGCCAAATCTTAAAAGATATCATGG

ACGACTACTACCGCGGTTTCATTAGCGAAACTCTTAGTTCAATTGACGACATTGACT

GGACGTCCTTGTTCGAAAAGATGGAGATTCAATTAAAGAACGGTGATAACAAGGAT

ACGTTGATTAAAGAACAGACGGAGTACCGTAAGGCTATCCACAAAAAATTTGCAAA

CGACGACCGCTTTAAAAATATGTTTAGCGCAAAATTAATCTCCGACATCCTGCCTGA

ATTCGTCATCCATAACAATAACTATAGCGCCTCGGAAAAAGAAGAAAAAACGCAGG

TTATTAAACTTTTCTCGCGCTTTGCAACAAGCTTTAAGGATTACTTCAAAAATCGCG C

CAATTGTTTTTCAGCCGACGACATTAGCTCCAGTTCCTGCCACCGTATTGTGAATGA C

AACGCTGAGATTTTTTTTTCCAATGCGCTGGTTTATCGTCGTATTGTTAAGAGCCTT A

GTAACGACGACATTAATAAAATTAGCGGTGATATGAAGGATAGCTTGAAAGAAATG

AGTCTGGAAGAGATCTATAGTTACGAGAAGTACGGCGAATTTATTACCCAGGAGGG

CATTTCATTTTACAATGATATCTGTGGAAAAGTCAACTCCTTTATGAACTTGTATTG C

CAAAAGAATAAAGAAAACAAAAACCTGTACAAACTGCAAAAGTTACACAAGCAGA

TTTTGTGTATCGCAGACACGTCATACGAAGTACCGTACAAGTTTGAGTCCGATGAAG

AAGTGTACCAAAGCGTTAATGGCTTTTTGGATAACATTTCGAGCAAACATATCGTAG

AGCGTTTGCGTAAGATTGGTGATAATTACAACGGTTACAATTTAGACAAAATCTATA

TCGTCTCTAAGTTTTACGAAAGTGTTTCTCAGAAAACTTACCGCGATTGGGAGACGA TCAACACTGCGCTGGAGATTCATTACAATAATATCCTTCCAGGTAACGGTAAAAGCA

AAGCTGATAAGGTGAAAAAGGCGGTTAAAAATGACCTTCAAAAGTCTATCACAGAA

ATCAACGAATTGGTCAGCAATTATAAGCTTTGCAGTGACGATAACATTAAGGCCGA

GACTTACATCCATGAGATCTCTCACATTCTTAATAATTTTGAAGCGCAAGAGCTGAA

ATACAATCCTGAAATCCATCTGGTCGAAAGTGAATTAAAAGCCTCCGAATTAAAAA

ATGTCTTGGACGTGATCATGAATGCGTTCCATTGGTGCTCAGTTTTTATGACGGAAG

AGTTGGTGGACAAAGACAACAATTTTTACGCCGAGCTTGAGGAAATTTACGACGAA

ATTTACCCCGTTATTTCGTTATACAACCTTGTGCGTAATTACGTTACACAAAAGCCC T

ATTCGACAAAGAAAATCAAGTTAAATTTCGGGATTCCCACATTAGCTGATGGATGGT

CCAAATCCAAAGAATACTCGAATAACGCTATCATCCTTATGCGTGATAATTTGTACT

ACTTAGGCATCTTCAATGCGAAGAACAAACCTGACAAGAAAATTATCGAAGGAAAC

ACTTCGGAGAACAAAGGTGATTATAAAAAGATGATCTACAACTTGCTTCCCGGGCC

AAACAAAATGATTCCCAAGGTATTTTTGAGTTCTAAAACCGGTGTCGAAACTTACAA

ACCAAGTGCTTATATTTTGGAAGGATACAAACAGAACAAACATATCAAGTCTTCGA

AAGACTTCGATATTACGTTCTGCCACGATCTGATCGATTACTTCAAGAACTGTATTG

CTATTCACCCCGAGTGGAAGAACTTTGGATTTGATTTCTCCGACACGTCCACTTATG

AAGATATCTCTGGCTTCTATCGCGAGGTTGAATTACAAGGGTATAAGATTGACTGGA

CTTATATTTCGGAGAAGGATATCGATCTTTTGCAAGAAAAAGGGCAACTTTATTTAT

TTCAGATCTATAACAAGGACTTTTCAAAAAAGAGCACTGGAAATGACAATCTGCAT

ACCATGTACCTTAAGAACCTGTTCTCGGAAGAGAACCTGAAGGACATTGTACTTAAA

CTGAATGGAGAGGCAGAGATCTTCTTTCGCAAATCAAGCATTAAGAACCCAATTATT

CACAAAAAGGGGAGTATCTTAGTAAATCGCACATATGAGGCTGAGGAAAAAGATCA

GTTTGGTAACATTCAGATCGTGCGTAAGAACATTCCTGAAAATATCTATCAGGAACT

TTATAAGTATTTCAACGATAAAAGTGATAAAGAGCTGAGTGACGAAGCGGCTAAAC

TTAAGAATGTTGTGGGACACCATGAGGCAGCAACCAATATTGTGAAGGATTATCGCT

ATACGTACGACAAATACTTTTTACACATGCCCATCACTATTAATTTTAAAGCTAATA

AGACTGGCTTCATTAACGATCGCATCCTGCAGTACATTGCTAAGGAAAAGGATCTTC

ACGTTATCGGTATCGATCGCGGGGAGCGTAATCTTATCTACGTCTCTGTCATTGACA

CGTGTGGCAATATTGTGGAGCAAAAGTCCTTCAATATTGTTAACGGCTATGACTATC

AGATTAAATTGAAACAGCAGGAAGGTGCGCGTCAGATTGCCCGCAAGGAATGGAAG

GAAATTGGCAAGATCAAAGAAATTAAGGAGGGCTACTTAAGCTTAGTAATTCACGA

AATTAGTAAAATGGTTATCAAATACAACGCCATCATCGCGATGGAGGATCTTTCGTA

CGGGTTT AAGAA AGGTCGTTTTAAAGT GGAGCGT C AGGT GT ACC AGAAATTTGAA A

CTATGCTTATTAACAAACTTAACTACCTGGTTTTCAAGGATATCAGTATTACTGAAA

ACGGGGGGCTGTTAAAAGGGTATCAATTAACTTACATTCCAGACAAATTAAAGAAC GTTGGACATCAGTGTGGCTGCATTTTTTATGTACCAGCTGCATACACTTCAAAGATC

GATCCTACGACTGGGTTCGTGAACATTTTTAAGTTTAAAGACTTGACGGTAGATGCC

AAGCGCGAATTCATCAAGAAATTCGACAGCATTCGCTACGACTCTGAGAAAAATCTT

TTCTGTTTCACATTCGATTATAACAATTTCATTACGCAGAACACAGTAATGTCCAAG T

CTTCTTGGAGTGTTTATACATATGGTGTCCGCATTAAGCGCCGTTTCGTCAACGGCC G

CTTCAGTAATGAGAGCGATACTATTGACATCACAAAAGACATGGAAAAAACACTGG

AAATGACCGACATCAATTGGCGTGACGGCCATGACTTACGTCAGGATATCATTGATT

ATGAGATCGTTCAACACATCTTCGAAATCTTTCGCTTGACTGTTCAAATGCGCAATT C

CTTGTCGGAATTGGAGGACCGTGATTATGACCGCTTAATTTCCCCCGTCTTAAATGA

AAACAATATTTTTTATGACTCTGCAAAAGCTGGAGATGCTCTGCCGAAAGACGCCGA

TGCAAATGGGGCATATTGCATTGCTTTAAAGGGGCTTTACGAGATCAAGCAAATCAC

CGAAAACTGGAAAGAGGATGGAAAGTTTTCGCGTGATAAACTGAAGATCTCTAACA

AAGACTGGTTCGACTTTATCCAGAACAAGCGTTATTTGAAACGTCCGGCAGCGACCA

AAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCC

GAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCT

AA

[0090] SEQ ID NO: 45

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGCACCAATAACTTCCAAAACTTCATCGGGATCTCTAGCCTTCAGAAGACGCT

TCGCAATGCTCTTATCCCAACTGAGACCACTCAACAATTTATTGTGAAGAATGGAAT

TATTAAAGAGGACGAACTGCGTGGCGAGAATCGTCAGATCTTAAAGGACATTATGG

ATGATTATTACCGTGGATTCATCTCCGAAACATTATCGTCGATCGATGATATCGATT

GGACTTCTCTGTTCGAGAAAATGGAAATTCAATTGAAAAACGGAGATAATAAAGAT

ACGCTTATCAAAGAACAGACGGAATATCGTAAAGCGATTCATAAGAAATTCGCAAA

TGACGATCGTTTCAAAAATATGTTCAGTGCCAAGCTTATTTCGGACATTTTACCTGA

ATTTGTAATTCATAATAATAACTACTCAGCAAGTGAGAAGGAGGAGAAAACCCAAG

TTATTAAACTGTTCTCTCGTTTCGCAACGTCCTTTAAAGATTACTTTAAAAACCGCG C

GAATTGCTTTAGCGCTGACGACATTTCCAGCTCATCCTGTCATCGCATCGTAAACGA

CAATGCGGAAATCTTCTTCAGCAACGCCCTGGTTTACCGCCGCATCGTCAAAAGCTT

ATCGAATGACGACATCAATAAGATCTCAGGAGATATGAAGGACTCGCTTAAGGAGA

TGTCTCTGGAGGAAATTTATAGTTACGAAAAGTATGGAGAGTTCATTACCCAGGAGG

GAATCTCGTTCTACAATGACATTTGCGGGAAGGTGAACTCCTTCATGAACTTATACT

GCCAGAAAAACAAAGAGAACAAAAATCTGTATAAATTGCAGAAATTACATAAACAG

ATTCTTTGTATTGCTGACACTTCCTACGAAGTACCCTATAAATTCGAGTCAGATGAA GAAGTATACCAGTCCGTGAACGGATTTCTGGACAATATCTCCTCAAAACACATCGTG

GAACGCTTACGTAAAATTGGCGATAATTATAATGGTTACAATCTTGACAAAATTTAT

ATCGTATCTAAATTTTACGAGAGTGTGAGCCAAAAGACCTACCGCGACTGGGAGAC

CATCAACACAGCTTTAGAAATTCACTATAATAATATCTTACCCGGCAATGGTAAGAG

CAAGGCTGACAAGGTAAAAAAGGCCGTCAAGAATGATTTGCAGAAATCTATTACAG

AAATTAATGAGTTAGTCTCCAACTATAAGCTTTGTTCCGACGATAACATCAAAGCTG

AGACATATATTCATGAGATTAGTCACATTCTTAACAACTTCGAGGCCCAGGAACTTA

AGTACAATCCTGAAATTCATCTTGTCGAGTCTGAGCTGAAAGCTAGTGAATTGAAAA

ATGTTTTAGACGTTATTATGAACGCATTCCACTGGTGCTCTGTGTTTATGACAGAAG

AACTGGTCGACAAGGACAATAACTTCTATGCCGAACTTGAGGAAATCTACGATGAA

ATTTACCCTGTAATCTCCTTGTATAATCTTGTACGTAATTACGTCACTCAAAAACCT T

ACAGCACGAAAAAAATTAAATTGAACTTCGGGATTCCTACACTTGCCGACGGGTGG

TCTAAATCCAAGGAATATAGCAACAATGCCATTATTTTAATGCGCGACAATCTTTAC

TATTTAGGAATTTTTAACGCTAAGAACAAGCCCGATAAAAAGATTATTGAAGGAAA

CACGTCTGAAAATAAGGGCGACTACAAAAAGATGATTTATAACCTTTTGCCCGGTCC

AAACAAAATGATCCCAAAGGTATTCCTGTCATCCAAAACAGGGGTTGAGACATATA

AGCCCAGCGCATATATTCTGGAAGGATACAAACAGAATAAACATATCAAAAGCAGC

AAAGATTTTGACATTACTTTTTGCCACGATTTAATCGACTACTTCAAAAACTGTATC G

CTATCCACCCTGAATGGAAGAATTTCGGATTTGATTTCTCAGATACAAGTACGTATG

AGGATATCAGCGGTTTCTATCGCGAAGTTGAACTTCAAGGGTATAAAATTGACTGGA

CCTACATTAGTGAGAAGGACATCGACCTGTTACAGGAAAAAGGCCAATTGTACTTGT

TTCAGATCTACAATAAGGATTTCTCAAAAAAATCGACCGGCAATGATAACTTGCACA

CCATGTACCTGAAGAACCTTTTTTCGGAGGAAAACCTTAAAGACATTGTCCTGAAGT

TGAATGGAGAAGCGGAGATTTTCTTTCGTAAGTCTTCCATTAAAAATCCAATTATTC

ATAAGAAGGGCAGCATCCTTGTGAACCGTACGTACGAGGCGGAAGAGAAGGACCA

ATTCGGTAACATTCAAATCGTCCGCAAGAACATCCCTGAAAATATTTATCAGGAGCT

TTACAAGTATTTCAATGATAAGTCCGACAAGGAATTATCAGATGAGGCTGCGAAGTT

GAAAAATGTTGTTGGTCATCACGAGGCGGCGACGAATATTGTAAAGGATTATCGCT

ACACTTATGACAAGTACTTTCTGCACATGCCGATCACCATTAATTTCAAGGCGAACA

AAACAGGATTTATTAATGACCGCATCTTACAATACATTGCCAAAGAAAAGGACTTAC

ACGTTATTGGCATTGATCGTGGAGAACGCAACTTAATCTACGTAAGCGTTATTGACA

CTTGCGGGAATATCGTAGAACAAAAGAGCTTCAACATCGTGAATGGTTACGATTACC

AGATCAAGCTTAAGCAGCAGGAGGGAGCGCGCCAGATCGCGCGCAAGGAATGGAA

GGAGATTGGTAAGATCAAGGAAATCAAGGAAGGTTATCTGTCCTTGGTAATCCACG

AAATTTCGAAAATGGTTATCAAATACAATGCTATTATTGCAATGGAGGACTTGTCCT ACGGCTTTAAAAAAGGACGCTTTAAGGTGGAGCGCCAGGTTTATCAAAAGTTTGAA

ACAATGCTGATTAACAAGCTGAACTATTTGGTCTTTAAAGATATCTCCATCACCGAA

AATGGTGGGCTTTTGAAAGGCTATCAACTTACATATATCCCTGATAAGCTTAAGAAT

GTGGGTCATCAGTGCGGGTGCATTTTTTATGTTCCTGCAGCCTACACGTCCAAAATC

GATCCTACAACTGGATTTGTTAATATCTTCAAATTTAAGGATCTTACCGTCGACGCG

AAGCGCGAATTTATCAAGAAATTCGATAGTATTCGTTATGATTCCGAAAAAAACCTT

TTCTGTTTCACCTTTGATTATAATAACTTTATCACGCAAAATACTGTCATGAGCAAA T

CGAGTTGGTCTGTGTACACTTACGGAGTACGCATCAAGCGTCGTTTTGTTAATGGGC

GCTTCAGTAACGAGTCAGACACGATTGATATCACAAAAGATATGGAGAAAACGCTG

GAGATGACAGACATCAATTGGCGCGATGGTCATGACTTACGTCAAGACATTATCGAT

TATGAAATTGTCCAGCATATCTTTGAGATCTTTCGTTTGACTGTTCAGATGCGCAAC A

GCCTGTCAGAATTGGAGGATCGTGACTATGATCGCCTTATTTCTCCCGTCTTAAATG

AGAACAATATCTTCTACGACTCAGCCAAGGCTGGAGATGCACTGCCAAAAGACGCC

GACGCAAATGGGGCCTACTGTATTGCATTGAAGGGGTTGTACGAGATCAAACAGAT

TACAGAAAATTGGAAGGAGGACGGTAAGTTCTCTCGTGATAAGCTGAAGATTTCTA

ACAAAGACTGGTTCGATTTCATTCAGAACAAACGTTACCTGAAACGTCCGGCAGCG

ACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCA

GCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCG

GGCTAA

[0091] SEQ ID NO: 46

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGTACCAATAACTTTCAGAATTTCATTGGAATCAGCAGCTTACAGAAAACCCT

GCGCAATGCACTTATCCCCACTGAGACAACCCAGCAGTTCATTGTAAAGAACGGGA

TTATTAAAGAAGATGAGCTTCGCGGGGAGAATCGTCAGATCTTAAAGGATATTATG

GACGATTACTACCGTGGCTTCATTTCGGAGACGCTGTCGTCGATCGACGACATCGAC

TGGACATCCTTGTTTGAAAAGATGGAAATCCAACTGAAGAATGGCGATAACAAGGA

CACGTTAATCAAAGAGCAGACGGAATACCGTAAAGCTATCCACAAAAAGTTCGCTA

ATGACGACCGCTTTAAGAACATGTTCTCAGCAAAACTTATTAGCGATATTTTACCTG

AATTTGTCATCCACAATAACAATTACTCCGCGAGTGAAAAAGAGGAGAAAACCCAG

GTGATTAAGCTGTTTTCCCGTTTTGCAACCAGTTTCAAGGACTATTTTAAGAATCGT G

CTAATTGTTTCTCTGCAGACGACATTTCCTCGTCGTCCTGCCATCGCATTGTTAATG A

TAATGCTGAAATCTTTTTTTCAAACGCACTTGTGTATCGTCGCATTGTCAAAAGCTT A

AGTAATGACGATATCAATAAGATCTCAGGAGACATGAAGGACTCCCTGAAAGAAAT

GTCATTGGAAGAAATTTACTCTTATGAAAAGTATGGAGAATTTATTACGCAGGAGGG TATCAGCTTCTATAACGACATTTGTGGTAAAGTGAACAGCTTTATGAATCTTTATTGT

CAAAAGAATAAAGAGAACAAAAATCTGTACAAGCTGCAGAAATTGCATAAACAAAT

TCTGTGCATTGCAGATACTTCGTATGAGGTTCCTTACAAATTCGAGTCGGATGAGGA

GGTGTATCAAAGCGTAAACGGATTTTTGGATAACATTAGTAGTAAGCATATTGTGGA

ACGCCTTCGCAAGATTGGTGACAACTATAACGGATACAACTTAGACAAGATCTATAT

TGTCTCGAAGTTTTACGAAAGTGTTTCCCAAAAGACTTATCGCGACTGGGAGACAAT

CAACACTGCGCTGGAAATTCACTATAACAATATCTTGCCGGGGAACGGAAAAAGTA

AGGCAGATAAGGTGAAGAAAGCAGTCAAAAATGATCTGCAAAAAAGCATTACTGA

AATTAACGAACTTGTGTCAAATTACAAATTGTGTTCGGATGACAATATTAAAGCGGA

AACGTATATCCACGAGATCTCGCACATTCTTAATAATTTCGAGGCGCAGGAATTAAA

GTATAATCCTGAGATCCATTTGGTGGAATCAGAACTTAAAGCTAGTGAACTGAAAA

ATGTCCTGGACGTTATTATGAATGCATTTCACTGGTGTTCTGTCTTTATGACAGAAG A

ACTTGTCGACAAAGACAACAACTTTTATGCGGAATTAGAAGAGATTTACGACGAAA

TTTATCCCGTTATTTCGTTATATAATTTAGTTCGTAATTACGTGACTCAGAAACCCT A

CAGCACAAAAAAGATTAAATTAAACTTTGGGATTCCGACTCTTGCTGATGGATGGAG

CAAGTCCAAGGAGTACTCTAATAACGCCATTATCTTGATGCGTGACAACCTGTACTA

CCTGGGCATTTTTAACGCTAAAAACAAACCCGACAAAAAGATCATTGAAGGGAACA

CCTCGGAAAATAAGGGGGACTATAAAAAAATGATCTACAATCTGTTGCCAGGCCCA

AATAAGATGATCCCAAAGGTTTTTTTATCTTCCAAAACTGGCGTAGAAACTTACAAG

CCGAGCGCATACATCCTTGAAGGATATAAACAAAACAAACATATCAAAAGTTCAAA

GGACTTCGATATTACGTTCTGCCATGATTTAATCGATTATTTCAAGAATTGCATCGC G

ATTCACCCAGAGTGGAAAAACTTTGGGTTTGATTTTTCAGACACCAGCACTTACGAG

GATATTAGTGGATTCTATCGTGAGGTTGAACTGCAGGGCTATAAAATTGACTGGACC

TATATTTCTGAAAAAGATATTGATCTGCTTCAGGAGAAAGGCCAATTGTACTTATTT

CAAATCTATAACAAGGATTTCTCCAAGAAGTCCACGGGTAATGACAACTTACACAC

AATGTATCTGAAGAATCTGTTTAGTGAGGAGAACTTGAAGGACATTGTGCTGAAGCT

TAATGGCGAGGCCGAAATCTTTTTTCGTAAGTCCTCCATTAAAAACCCTATTATCCA T

AAGAAAGGGAGTATTCTTGTCAACCGCACGTATGAGGCCGAAGAAAAGGACCAATT

CGGAAACATCCAAATTGTCCGTAAAAATATTCCTGAGAACATTTACCAGGAGCTTTA

CAAGTATTTCAACGACAAGAGTGATAAAGAACTTTCAGATGAGGCGGCGAAACTGA

AGAATGTAGTGGGGCACCACGAAGCTGCCACGAATATTGTAAAGGATTACCGTTAC

ACCTACGACAAGTACTTTTTGCATATGCCCATCACAATTAATTTTAAGGCCAATAAA

ACTGGTTTTATCAACGATCGTATCTTACAGTACATTGCTAAGGAAAAAGATCTGCAC

GTTATCGGTATCGATCGCGGGGAACGCAATCTGATTTATGTTAGTGTGATTGACACG

TGCGGAAATATTGTTGAGCAGAAGAGCTTTAATATCGTAAATGGATATGACTATCAA ATTAAACTGAAGCAACAGGAAGGGGCCCGCCAGATTGCCCGCAAGGAGTGGAAAG

AAATTGGAAAGATCAAGGAGATTAAAGAAGGGTACCTTTCCCTTGTTATCCACGAA

ATCTCGAAAATGGTGATCAAGTACAATGCCATTATTGCTATGGAGGATCTGTCATAT

GGGTTTAAGAAAGGCCGCTTTAAGGTGGAACGTCAGGTTTACCAGAAGTTTGAGAC

CATGCTTATCAATAAGCTGAATTATCTTGTCTTCAAAGACATCTCAATCACAGAGAA

CGGCGGGCTGTTAAAAGGATATCAGCTGACCTATATCCCCGACAAACTGAAAAATG

TCGGGCACCAATGCGGCTGTATTTTCTACGTGCCCGCTGCATACACATCTAAAATTG

ACCCAACGACTGGATTCGTAAATATTTTTAAGTTTAAGGATCTTACGGTAGATGCAA

AGCGCGAATTTATCAAGAAATTTGATAGTATCCGTTACGACAGCGAGAAAAACTTAT

TTTGTTTTACGTTCGATTATAACAACTTCATCACGCAAAATACCGTCATGTCAAAAT C

TTCCTGGTCAGTCTATACGTATGGCGTCCGTATCAAGCGCCGCTTCGTCAACGGGCG

TTTTTCAAACGAGTCAGATACCATCGATATCACCAAAGATATGGAAAAAACATTGG

AGATGACGGACATCAATTGGCGCGATGGTCATGACTTACGCCAGGACATTATTGACT

ACGAAATCGTACAACATATTTTTGAGATTTTCCGTCTGACCGTGCAAATGCGCAACT

CATTATCCGAACTTGAGGATCGTGATTACGACCGCTTGATCAGTCCTGTTCTGAACG

AGAATAATATTTTTTACGACAGTGCCAAGGCGGGAGACGCACTGCCCAAGGACGCT

GACGCTAACGGAGCTTATTGTATTGCGTTGAAGGGACTTTACGAAATCAAGCAAATC

ACTGAAAACTGGAAGGAGGATGGTAAATTCTCACGCGACAAGTTGAAAATTTCGAA

CAAGGACTGGTTCGATTTCATCCAAAACAAGCGTTATTTAAAACGTCCGGCAGCGAC

CAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGC

CCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0092] SEQ ID NO: 47

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGGACTAATAACTTCCAGAACTTCATCGGTATTTCATCATTACAAAAAACGCT

TCGTAACGCCTTGATCCCAACAGAAACGACCCAACAATTTATTGTAAAAAACGGCAT

CATCAAAGAAGACGAACTGCGTGGCGAAAATCGCCAAATTTTGAAGGACATTATGG

ATGACTATTATCGTGGGTTTATCTCGGAGACATTATCCTCCATCGACGACATTGATT G

GACGAGTCTTTTTGAGAAAATGGAGATCCAGCTTAAAAATGGTGATAACAAGGATA

CATTGATCAAGGAGCAAACCGAGTACCGCAAGGCCATCCATAAGAAGTTCGCAAAT

GACGACCGCTTCAAAAATATGTTTAGTGCCAAATTGATCTCGGATATCCTTCCTGAG

TTCGTAATTCACAACAATAATTATAGCGCATCCGAAAAGGAGGAAAAGACTCAAGT

CATTAAGCTTTTCAGTCGCTTTGCTACCTCGTTTAAGGACTATTTCAAGAACCGCGC G

AACTGCTTCTCAGCGGATGACATTTCTTCCTCGTCGTGTCACCGCATCGTGAATGAT A ATGCGGAGATCTTCTTTAGTAATGCCTTGGTATACCGCCGCATTGTTAAATCCCTGTC

TAACGACGATATCAATAAGATCTCAGGAGATATGAAGGATAGCCTTAAAGAAATGT

CTCTGGAAGAAATTTACTCCTATGAAAAGTACGGTGAGTTTATCACCCAAGAGGGG

ATTAGCTTTTATAACGATATCTGCGGGAAGGTGAATTCGTTTATGAACCTTTATTGT C

AAAAGAATAAGGAGAATAAGAACTTATATAAGCTTCAGAAACTGCATAAACAAATC

TTATGCATTGCCGATACTAGCTATGAAGTTCCGTATAAATTCGAGAGCGATGAAGAA

GTTTATCAGAGCGTCAATGGGTTCTTGGATAACATTTCATCAAAACACATCGTGGAA

CGTCTGCGTAAGATTGGGGATAACTACAACGGATATAATCTTGACAAAATTTATATT

GTATCTAAATTCTATGAGTCGGTGAGTCAAAAGACCTACCGTGATTGGGAAACAATC

AATACCGCGTTAGAAATCCACTATAACAACATTCTGCCAGGGAATGGTAAAAGTAA

AGCGGACAAAGTCAAGAAGGCTGTGAAGAACGATCTGCAAAAGAGTATTACAGAG

ATTAACGAATTAGTCTCCAATTATAAGTTATGCTCGGACGATAACATTAAGGCGGAG

ACGTATATTCATGAGATTTCGCATATTCTTAACAACTTCGAGGCACAAGAGCTTAAG

TATAACCCAGAGATTCACCTTGTCGAATCGGAGCTGAAGGCATCGGAATTAAAAAA

TGTCTTAGATGTAATCATGAACGCGTTCCATTGGTGCAGTGTTTTCATGACTGAGGA

GTTAGTTGACAAGGACAATAACTTCTACGCAGAATTAGAAGAGATCTATGATGAGA

TTTATCCAGTGATTTCGCTGTATAATCTGGTACGTAATTACGTCACTCAAAAGCCCT A

CTCAACAAAAAAAATTAAGCTGAACTTCGGAATTCCGACTCTGGCCGACGGGTGGT

CCAAGTCAAAGGAGTATTCTAATAATGCTATCATCCTGATGCGCGATAACTTATACT

ATTTGGGAATTTTCAATGCCAAAAATAAACCAGATAAAAAGATTATCGAAGGTAAT

ACAAGCGAGAATAAGGGTGACTATAAGAAAATGATTTACAATCTTCTTCCAGGCCCT

AACAAGATGATTCCCAAAGTTTTTTTGTCCAGTAAAACAGGGGTCGAAACTTACAAG

CCCAGTGCCTATATCCTTGAAGGGTACAAGCAGAATAAGCACATCAAATCCTCGAA

AGACTTTGATATTACATTTTGTCATGACTTAATCGATTATTTTAAGAACTGTATCGC A

ATCCATCCAGAATGGAAGAACTTCGGGTTTGATTTCTCTGATACTTCCACGTATGAG

GATATTTCCGGGTTCTACCGCGAAGTAGAGCTTCAGGGCTATAAAATTGACTGGACA

TATATTTCAGAAAAAGACATCGATCTGTTACAAGAAAAAGGACAGTTGTATCTGTTT

CAAATCTATAATAAGGATTTCTCCAAAAAGTCAACTGGAAATGATAACTTACATACA

ATGTATCTGAAAAATCTTTTTAGTGAAGAGAATTTGAAGGATATCGTGCTGAAGTTA

AATGGCGAAGCAGAGATCTTCTTCCGCAAGTCCTCGATCAAGAATCCTATCATCCAC

AAGAAAGGTAGTATTCTGGTTAACCGCACGTACGAGGCCGAGGAAAAAGACCAGTT

CGGTAATATCCAGATTGTACGTAAGAATATTCCTGAAAATATTTACCAGGAATTATA

CAAGTATTTTAACGACAAATCGGATAAGGAGCTTTCAGATGAGGCCGCAAAGTTGA

AGAACGTCGTAGGACACCATGAGGCCGCTACGAATATCGTCAAGGACTACCGCTAT

ACGTATGACAAGTACTTCCTGCACATGCCTATTACTATCAATTTCAAAGCTAATAAA ACAGGATTCATCAATGATCGTATCCTTCAGTACATTGCCAAAGAAAAAGATCTGCAC

GTAATCGGAATCGACCGTGGCGAACGTAATCTGATTTACGTATCAGTTATCGACACA

TGTGGTAACATCGTGGAGCAGAAATCTTTTAACATTGTTAACGGCTATGATTATCAG

ATTAAGCTTAAACAGCAGGAGGGGGCACGCCAAATCGCTCGTAAAGAATGGAAGGA

GATTGGAAAGATTAAAGAGATTAAAGAGGGGTACCTTTCGCTGGTTATTCACGAAA

TTTCCAAGATGGTGATTAAGTACAATGCAATCATCGCGATGGAAGATCTTAGTTACG

GATTCAAAAAGGGACGCTTCAAAGTTGAGCGTCAGGTCTACCAGAAATTTGAAACG

ATGCTGATTAACAAATTGAATTACTTGGTATTCAAAGATATCTCAATTACTGAAAAT

GGTGGCTTATTAAAGGGTTACCAGCTTACCTATATCCCGGATAAGCTGAAGAACGTG

GGCCATCAATGCGGCTGCATCTTTTACGTCCCTGCCGCATATACCTCTAAAATTGAC

CCCACCACCGGATTCGTAAATATTTTTAAATTCAAGGACCTGACGGTGGACGCCAAG

CGCGAATTCATCAAAAAATTCGACTCAATCCGCTATGATTCCGAAAAAAATCTTTTC

TGCTTTACGTTCGATTATAATAACTTCATTACCCAAAACACGGTGATGTCAAAATCG

TCCTGGAGCGTGTATACTTATGGAGTGCGTATCAAGCGCCGCTTTGTTAATGGGCGC

TTCAGTAACGAAAGCGATACCATCGACATTACCAAAGACATGGAGAAGACGCTTGA

AATGACGGATATCAATTGGCGTGACGGACACGATCTTCGTCAGGATATCATCGACTA

CGAGATTGTGCAACATATCTTTGAGATTTTCCGTTTAACTGTTCAAATGCGTAACTC C

TTGTCCGAATTGGAAGACCGTGATTACGACCGCTTGATTTCACCAGTGCTTAACGAG

AATAACATCTTCTACGACTCCGCCAAAGCAGGCGATGCCCTGCCAAAGGACGCTGA

TGCAAATGGTGCATACTGTATCGCGTTGAAGGGCTTATACGAGATTAAGCAAATCAC

CGAAAATTGGAAAGAGGATGGAAAGTTCAGTCGCGATAAGCTGAAGATCTCTAATA

AAGATTGGTTTGACTTTATCCAGAACAAACGTTATTTAAAACGTCCGGCAGCGACCA

AAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCC

GAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCT

AA

[0093] SEQ ID NO: 48

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGTACCAATAATTTCCAAAATTTCATCGGAATCTCATCCTTGCAAAAAACCTT

GCGCAATGCTTTGATCCCCACCGAAACCACGCAGCAGTTCATCGTGAAAAACGGCA

TTATCAAAGAGGATGAGTTGCGCGGGGAAAACCGTCAAATTCTTAAGGATATCATG

GACGATTACTACCGTGGGTTTATCAGTGAGACCCTGTCAAGCATTGACGACATTGAC

TGGACCAGCTTATTTGAGAAGATGGAGATTCAATTAAAGAACGGGGACAATAAGGA

CACGCTTATCAAAGAGCAGACAGAATACCGTAAAGCGATTCATAAGAAATTTGCAA

ATGACGATCGCTTCAAGAACATGTTTTCAGCAAAATTAATCAGCGACATCCTTCCCG AATTTGTGATTCATAATAACAACTATTCGGCTAGCGAAAAAGAGGAGAAAACTCAG

GTTATTAAGCTTTTCTCGCGTTTTGCCACTTCGTTCAAAGACTATTTTAAGAATCGC G

CAAACTGCTTTTCGGCTGATGATATTTCCAGTTCTAGCTGCCATCGTATCGTTAACG A

TAATGCTGAGATTTTCTTCTCTAATGCCCTGGTGTATCGTCGTATCGTTAAATCTTT G

AGCAACGACGATATTAATAAGATTTCAGGCGACATGAAGGATTCTTTAAAGGAGAT

GTCTTTAGAAGAGATTTATTCCTATGAGAAATATGGCGAGTTTATCACCCAAGAAGG

AATTTCGTTCTACAACGACATCTGTGGCAAAGTGAACAGCTTCATGAATTTATACTG

CCAAAAGAATAAGGAGAATAAAAATTTATATAAACTGCAGAAACTGCATAAGCAAA

TTCTTTGCATTGCAGACACCTCTTATGAAGTTCCTTATAAGTTTGAATCGGACGAGG

AGGTATATCAGAGTGTGAACGGGTTCCTGGACAATATTTCATCCAAGCATATTGTTG

AACGTTTACGCAAAATTGGAGACAATTACAATGGGTATAACCTTGACAAAATTTACA

TCGTGTCGAAGTTTTACGAATCGGTAAGCCAGAAGACCTATCGTGACTGGGAAACTA

TCAATACCGCCTTAGAAATTCATTACAACAATATTCTTCCTGGTAACGGCAAAAGCA

AAGCCGATAAGGTAAAGAAGGCTGTCAAGAACGACCTGCAAAAGTCTATCACAGAG

ATCAACGAGTTAGTCTCTAACTACAAATTATGTTCCGACGACAATATTAAAGCCGAA

ACCTACATCCATGAGATCTCACACATTCTTAACAATTTTGAGGCCCAGGAGCTGAAA

TATAACCCAGAAATTCACCTTGTAGAGAGCGAATTAAAAGCCTCCGAGCTGAAGAA

CGTTTTGGATGTAATCATGAACGCATTTCATTGGTGCAGCGTATTTATGACAGAGGA

GTTGGTCGACAAGGACAATAACTTTTACGCCGAGCTTGAAGAAATCTACGATGAAA

TTTACCCGGTAATTAGTTTATATAATTTAGTTCGCAACTACGTAACTCAGAAACCCT A

CAGTACCAAGAAGATTAAATTGAACTTTGGGATCCCGACACTTGCTGACGGTTGGAG

TAAATCAAAAGAATACTCCAATAATGCAATTATCCTGATGCGCGACAATCTTTACTA

CTTGGGGATCTTTAACGCAAAGAACAAACCAGATAAGAAAATCATCGAGGGCAACA

CCAGCGAGAATAAAGGCGATTACAAGAAAATGATCTATAATCTTTTGCCGGGACCG

AACAAAATGATCCCAAAGGTTTTCCTGTCGTCGAAAACGGGAGTCGAGACATATAA

ACCATCTGCGTACATCTTGGAAGGTTACAAACAGAATAAGCATATTAAGTCTAGTAA

AGACTTCGACATCACCTTTTGTCATGACCTGATTGATTATTTCAAGAACTGTATTGC T

ATCCATCCAGAATGGAAAAACTTCGGATTTGACTTCTCCGATACTAGCACCTACGAA

GACATTTCGGGTTTTTATCGCGAAGTAGAGCTTCAAGGGTACAAAATTGATTGGACA

TATATTAGCGAGAAAGACATTGATTTGCTTCAAGAGAAGGGACAGTTATATTTATTC

CAGATCTACAACAAAGACTTCTCGAAGAAATCCACCGGTAATGATAATCTTCACACT

ATGTACCTGAAGAATTTATTTTCAGAGGAAAATCTGAAGGACATTGTACTTAAACTT

AATGGAGAAGCCGAAATCTTCTTCCGCAAGAGTTCCATTAAAAATCCGATTATTCAT

AAAAAGGGAAGTATCCTTGTGAACCGCACGTATGAGGCCGAAGAGAAGGATCAGTT

TGGGAATATTCAAATTGTCCGCAAAAACATCCCCGAGAACATCTACCAGGAACTGT ATAAATACTTTAATGATAAATCTGATAAAGAGTTATCAGACGAGGCTGCCAAACTG

AAAAACGTAGTCGGTCATCATGAGGCAGCGACCAATATTGTAAAGGACTACCGTTA

CACCTACGACAAGTATTTCCTTCACATGCCGATCACGATTAATTTTAAGGCTAACAA

GACCGGCTTTATCAATGACCGCATCTTGCAGTACATCGCGAAAGAGAAAGATTTACA

CGTCATCGGAATTGATCGTGGAGAGCGTAATCTTATCTACGTCAGCGTCATCGACAC

CTGTGGAAACATTGTGGAACAAAAAAGTTTTAATATCGTAAACGGCTACGACTATCA

AATTAAACTTAAACAGCAAGAGGGAGCTCGCCAGATCGCTCGCAAAGAGTGGAAAG

AGATTGGGAAAATTAAAGAAATTAAAGAGGGTTACCTGTCGCTGGTAATTCACGAA

ATCTCGAAAATGGTCATCAAATATAATGCAATTATCGCTATGGAGGATCTGTCCTAC

GGGTTCAAGAAGGGACGTTTTAAAGTAGAGCGCCAGGTGTATCAAAAATTCGAAAC

CATGTTGATCAATAAGCTTAACTATTTGGTCTTCAAAGATATTTCGATTACGGAGAA

CGGAGGTTTGTTGAAAGGATATCAGCTGACGTATATCCCAGACAAGTTGAAAAACG

TGGGGCATCAATGTGGATGTATTTTCTATGTGCCCGCGGCCTACACGAGTAAGATCG

ATCCTACCACTGGTTTCGTCAACATTTTCAAATTTAAAGATCTTACCGTGGATGCGA

AGCGCGAATTTATTAAGAAATTTGATAGCATTCGCTATGATTCCGAAAAGAACCTGT

TCTGTTTTACGTTCGACTATAACAATTTCATTACCCAAAACACGGTGATGAGCAAAT

CCTCTTGGTCAGTTTATACATACGGTGTACGTATCAAACGCCGTTTCGTTAACGGAC

GCTTTTCCAATGAGTCTGATACAATCGATATCACGAAAGATATGGAAAAAACATTAG

AGATGACTGATATCAACTGGCGTGACGGGCACGACCTGCGTCAAGACATTATTGACT

ACGAGATTGTGCAGCATATCTTCGAAATCTTTCGCTTAACTGTGCAAATGCGTAACT

CGTTATCCGAGTTAGAAGACCGTGACTACGATCGCCTGATTTCACCCGTCTTGAACG

AAAATAACATCTTCTACGATTCCGCGAAGGCTGGGGACGCATTGCCCAAGGACGCA

GACGCGAATGGAGCGTACTGTATTGCGCTTAAAGGATTATATGAAATCAAGCAGAT

CACCGAAAATTGGAAGGAGGACGGGAAGTTCTCACGCGACAAACTGAAGATTTCAA

ATAAGGACTGGTTCGATTTCATTCAGAATAAGCGTTACCTGAAACGTCCGGCAGCGA

CCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAG

CCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0094] SEQ ID NO: 49

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAATGGTACGAACAACTTTCAGAACTTCATCGGCATCTCCAGCCTTCAAAAGACTTT

ACGCAACGCATTGATTCCCACGGAGACTACGCAACAGTTTATCGTAAAAAATGGTAT

TATCAAAGAAGATGAATTACGCGGGGAGAATCGCCAGATTCTTAAGGACATTATGG

ACGATTATTACCGTGGATTCATCAGTGAGACACTGAGCTCCATTGATGACATCGACT GGACGTCATTGTTTGAAAAGATGGAAATCCAGTTGAAAAATGGCGATAACAAAGAT

ACATTGATTAAAGAGCAGACAGAGTACCGCAAAGCAATTCACAAGAAATTCGCCAA

TGATGATCGTTTTAAGAACATGTTTAGTGCCAAGCTTATTTCGGATATCTTACCCGA A

TTCGTGATTCACAACAACAATTATTCGGCAAGTGAGAAAGAGGAAAAGACCCAGGT

TATCAAATTGTTTTCGCGCTTCGCCACTTCGTTCAAAGATTATTTCAAGAACCGTGC A

AACTGTTTCTCCGCTGACGACATCAGTTCCAGCTCATGCCACCGTATTGTAAATGAC

AATGCGGAGATCTTTTTCAGTAATGCCTTAGTATATCGTCGCATTGTAAAGAGCTTA

TCTAATGATGACATTAACAAGATCTCGGGTGATATGAAGGACTCACTTAAGGAGAT

GAGTCTGGAAGAGATCTACTCCTACGAAAAATACGGGGAATTCATCACCCAGGAGG

GAATTTCATTCTACAACGATATCTGCGGCAAAGTTAACTCCTTTATGAATCTGTACT G

TCAAAAGAACAAGGAGAATAAAAACCTGTATAAATTGCAGAAACTTCATAAACAAA

TTTTGTGTATCGCAGACACGAGTTATGAAGTACCTTATAAATTCGAATCCGACGAAG

AGGTATATCAGTCCGTAAATGGGTTCCTGGACAATATCAGTAGTAAGCACATTGTGG

AACGCTTACGCAAAATTGGAGACAATTACAACGGGTATAACCTGGACAAAATCTAC

ATCGTATCCAAATTTTATGAAAGCGTGTCTCAAAAAACTTATCGTGATTGGGAAACA

ATCAACACGGCTCTTGAGATCCATTACAATAACATCTTGCCGGGTAACGGCAAATCG

AAGGCAGACAAAGTTAAAAAAGCAGTTAAGAACGACTTACAGAAAAGCATTACGG

AGATTAACGAGTTAGTAAGTAATTACAAATTATGCTCCGACGATAATATCAAAGCTG

AAACCTACATCCATGAAATTAGCCACATTTTGAACAATTTCGAAGCGCAGGAGCTGA

AATATAACCCTGAAATCCATCTGGTAGAGTCTGAGTTGAAGGCGTCAGAACTGAAA

AACGTTCTTGACGTCATCATGAATGCCTTTCACTGGTGTAGTGTTTTTATGACTGAG G

AGCTTGTAGATAAGGACAACAACTTCTATGCTGAACTTGAAGAGATCTACGATGAA

ATCTACCCCGTAATCAGTCTGTATAATTTAGTTCGTAACTACGTCACGCAGAAACCC

TATTCGACTAAGAAAATTAAGCTGAACTTTGGGATCCCTACTTTGGCAGACGGGTGG

AGCAAGAGTAAAGAATACAGTAATAATGCAATTATCTTGATGCGCGATAACTTATAT

TACTTAGGTATTTTCAATGCTAAGAACAAACCTGATAAGAAGATTATCGAAGGAAAT

ACGAGTGAGAATAAGGGAGACTACAAAAAGATGATTTACAACTTGCTGCCAGGGCC

TAATAAGATGATTCCAAAAGTTTTTCTGTCGAGCAAGACAGGGGTTGAAACTTATAA

GCCATCCGCTTATATCCTTGAGGGGTACAAGCAGAATAAGCATATCAAGTCCTCCAA

AGATTTTGATATTACATTTTGCCACGACTTAATTGATTACTTCAAGAACTGCATCGC A

ATCCATCCCGAATGGAAGAATTTCGGCTTCGATTTCTCAGATACGTCCACGTATGAG

GATATCTCAGGCTTTTACCGCGAAGTTGAGCTGCAAGGTTATAAAATTGATTGGACA

TACATCTCCGAAAAAGACATTGATCTTTTACAGGAAAAGGGCCAATTATACTTATTT

CAAATCTATAACAAAGATTTTAGCAAGAAGTCCACAGGTAATGATAACCTGCATAC

GATGTATTTGAAAAATCTTTTCAGTGAAGAGAATTTGAAGGATATCGTCCTGAAGCT GAACGGTGAGGCTGAGATCTTCTTCCGCAAATCGTCTATCAAAAACCCCATCATTCA

CAAAAAGGGAAGTATCTTAGTAAACCGCACTTATGAAGCGGAGGAAAAGGATCAGT

TCGGGAACATCCAGATCGTGCGCAAGAACATTCCAGAAAACATCTATCAGGAACTT

TACAAATATTTCAATGACAAGTCTGATAAAGAATTATCAGACGAGGCGGCGAAACT

TAAAAATGTTGTTGGACACCACGAAGCAGCGACGAATATTGTAAAGGATTATCGCT

ACACATACGATAAATACTTTTTGCACATGCCAATCACCATTAACTTTAAGGCGAACA

AGACAGGTTTCATTAACGACCGTATTCTGCAATATATCGCAAAGGAAAAAGACCTG

CACGTTATTGGGATCGATCGTGGCGAACGCAATTTGATCTACGTAAGCGTTATCGAC

ACTTGCGGAAATATCGTTGAACAAAAAAGCTTTAATATCGTCAATGGATACGATTAC

CAAATCAAGCTGAAACAACAAGAAGGGGCACGTCAGATCGCTCGTAAAGAATGGA

AAGAGATTGGTAAGATCAAAGAGATTAAAGAAGGGTATCTTTCTTTAGTAATTCACG

AGATTTCGAAAATGGTTATTAAATACAATGCGATTATTGCTATGGAAGACTTAAGCT

ACGGCTTTAAGAAAGGTCGCTTCAAAGTGGAGCGCCAAGTGTATCAGAAGTTTGAA

ACGATGTTGATTAACAAATTAAATTACCTGGTCTTTAAGGACATCAGTATCACAGAA

AATGGGGGGTTGCTTAAAGGGTACCAGCTTACATACATCCCTGATAAACTGAAAAA

TGTCGGTCATCAGTGCGGATGTATCTTCTATGTACCAGCAGCCTATACCAGTAAGAT

TGACCCTACTACTGGCTTTGTGAATATTTTTAAATTCAAGGATTTAACCGTGGACGC C

AAGCGTGAATTTATTAAAAAATTTGATTCGATTCGCTACGACAGTGAGAAAAACCTT

TTCTGCTTTACCTTTGACTACAACAATTTTATTACCCAGAACACCGTAATGTCAAAG A

GTTCGTGGTCTGTATATACCTACGGTGTTCGCATCAAGCGCCGCTTCGTAAACGGGC

GTTTCAGTAACGAATCTGACACCATCGACATCACTAAAGATATGGAGAAGACATTG

GAAATGACGGACATTAATTGGCGTGATGGCCATGACTTACGTCAGGACATTATTGAT

TACGAAATTGTGCAGCATATCTTCGAGATTTTCCGTTTGACAGTTCAGATGCGCAAC

TCACTGAGTGAGTTAGAAGATCGCGATTACGACCGTCTGATCTCACCGGTCCTTAAT

GAAAACAACATTTTCTACGACTCAGCAAAGGCGGGTGATGCCCTGCCAAAGGATGC

GGACGCTAATGGCGCCTACTGCATCGCCCTGAAAGGATTGTATGAAATTAAGCAGA

TTACAGAAAATTGGAAGGAAGATGGTAAATTTAGCCGTGATAAATTAAAAATCTCG

AACAAGGATTGGTTCGATTTTATTCAGAACAAACGTTATTTGAAACGTCCGGCAGCG

ACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCA

GCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCG

GGCTAA

[0095] SEQ ID NO: 50

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAATGGAACAAATAATTTTCAAAATTTTATCGGCATCTCAAGTCTTCAAAAAACCCT TCGCAATGCCCTGATTCCAACTGAAACAACCCAGCAATTTATCGTCAAGAACGGCAT

CATTAAGGAAGACGAGTTACGCGGGGAGAACCGTCAAATCCTGAAAGATATCATGG

ATGACTACTATCGTGGGTTCATTTCGGAAACCTTGTCTTCAATCGACGACATTGACT

GGACGAGTCTTTTCGAGAAAATGGAAATTCAGCTTAAAAATGGAGACAACAAGGAT

ACTCTGATTAAGGAACAGACAGAATATCGCAAAGCTATCCACAAAAAGTTCGCTAA

TGATGATCGTTTCAAAAATATGTTTTCTGCTAAATTGATTTCCGATATCTTGCCTGA A

TTTGTAATCCACAACAACAATTATTCTGCTTCCGAGAAGGAAGAGAAGACCCAGGTC

ATTAAATTATTCAGCCGCTTTGCAACCAGCTTTAAAGACTACTTTAAGAATCGCGCT

AACTGCTTTTCGGCGGATGACATCTCATCATCATCATGCCACCGCATTGTGAACGAC

AATGCGGAGATCTTCTTTTCGAATGCGTTAGTTTATCGTCGCATTGTCAAAAGTCTT A

GCAATGATGACATCAACAAGATCTCAGGAGACATGAAAGATTCCTTAAAGGAGATG

TCTCTTGAGGAAATCTATTCGTATGAGAAATACGGCGAGTTCATTACCCAGGAAGGT

ATTAGTTTCTACAATGATATCTGCGGCAAAGTAAATTCTTTTATGAATCTGTATTGC C

AAAAAAACAAAGAAAACAAGAATCTTTATAAGTTACAAAAGTTACATAAGCAAATT

CTGTGCATCGCTGATACATCTTATGAGGTACCCTACAAATTTGAAAGTGATGAGGAG

GTCTATCAGAGTGTCAACGGCTTCTTAGACAACATCTCTTCCAAACATATCGTGGAA

CGCCTGCGTAAAATCGGAGATAACTACAACGGATATAACTTAGATAAAATCTACAT

CGTGTCCAAGTTTTATGAAAGTGTGAGCCAAAAAACATATCGTGACTGGGAAACCA

TTAACACCGCATTGGAAATTCACTATAACAACATTTTGCCAGGCAACGGGAAAAGT

AAGGCGGACAAAGTTAAGAAAGCAGTTAAAAATGACCTGCAAAAAAGCATCACTG

AAATTAACGAATTGGTATCGAATTACAAATTATGTAGCGACGATAATATCAAAGCA

GAAACTTACATTCACGAGATTAGTCACATTTTAAATAACTTCGAGGCCCAGGAATTG

AAATACAATCCCGAAATTCATTTGGTTGAATCAGAACTGAAAGCATCAGAGTTGAA

AAATGTGTTAGATGTCATTATGAATGCGTTTCATTGGTGCTCTGTGTTCATGACCGA G

GAACTGGTTGATAAAGATAACAACTTTTACGCTGAATTGGAGGAGATTTACGATGA

GATTTACCCGGTCATTTCGCTTTATAACTTAGTGCGCAATTATGTGACGCAGAAACC

ATATTCCACGAAGAAAATCAAACTTAATTTTGGCATCCCTACTCTGGCTGATGGTTG

GTCGAAATCGAAAGAGTACAGCAACAACGCGATCATTCTTATGCGTGACAATCTTTA

CTATTTGGGCATTTTTAATGCCAAGAATAAGCCAGATAAGAAAATCATTGAGGGGA

ATACTTCCGAGAATAAGGGGGATTACAAAAAGATGATCTATAACTTGCTGCCCGGC

CCCAACAAAATGATTCCTAAGGTTTTCTTGTCAAGCAAGACGGGCGTCGAAACATAT

AAGCCGTCAGCTTATATTCTGGAAGGCTATAAACAGAATAAGCACATCAAGTCTTCC

AAGGACTTTGACATCACTTTTTGCCACGATTTGATCGACTACTTTAAGAACTGTATT G

CGATTCATCCGGAATGGAAGAACTTCGGTTTCGACTTTTCCGATACCTCAACATACG

AGGATATCAGCGGCTTCTACCGTGAAGTCGAGCTTCAAGGCTACAAGATCGATTGG ACATATATTTCAGAGAAGGACATTGATTTGTTACAAGAGAAAGGTCAACTTTACTTA

TTTCAGATCTATAACAAAGACTTTTCGAAGAAATCGACAGGAAACGATAACTTACAC

ACTATGTATTTAAAAAATCTGTTTTCGGAGGAAAACCTGAAAGATATTGTGCTGAAA

CTTAACGGCGAGGCAGAGATCTTTTTCCGTAAAAGCTCAATCAAGAATCCTATCATC

CATAAAAAAGGTAGTATTCTTGTCAACCGCACATATGAAGCGGAGGAGAAGGACCA

ATTCGGAAACATCCAAATTGTCCGTAAGAATATTCCGGAGAACATTTACCAAGAGTT

GTATAAATACTTTAACGATAAGTCAGATAAGGAACTTAGCGATGAGGCGGCGAAGC

TTAAAAACGTAGTTGGGCATCATGAAGCTGCTACCAACATTGTAAAAGATTACCGTT

ACACCTATGACAAGTATTTCTTGCACATGCCCATTACGATCAATTTCAAAGCAAATA

AGACAGGCTTTATCAATGATCGCATCCTGCAGTACATTGCTAAAGAGAAGGATTTGC

ATGTTATCGGTATTGATCGCGGAGAGCGCAATTTGATCTACGTCTCCGTAATCGACA

CTTGCGGTAACATTGTTGAGCAGAAGTCGTTCAACATCGTTAATGGTTATGATTACC

AAATCAAGCTGAAGCAGCAAGAGGGTGCCCGCCAGATCGCGCGTAAGGAATGGAA

AGAAATCGGGAAAATTAAAGAGATCAAAGAAGGCTATTTGTCTCTGGTAATTCACG

AAATCAGCAAGATGGTGATCAAGTATAACGCGATCATTGCGATGGAGGATCTTTCTT

ATGGCTTCAAGAAAGGGCGCTTTAAAGTCGAACGCCAGGTCTACCAGAAATTTGAG

ACAATGCTTATCAACAAGCTTAACTATCTTGTATTTAAGGATATTTCCATCACTGAG

AACGGAGGACTTTTAAAGGGGTACCAACTGACGTACATTCCTGATAAGCTGAAGAA

CGTTGGTCATCAATGCGGATGCATCTTCTATGTGCCAGCGGCTTACACCTCCAAAAT

CGATCCCACTACAGGCTTTGTCAATATCTTCAAATTCAAGGATTTGACCGTTGACGC

GAAGCGCGAGTTTATCAAGAAGTTTGATAGCATTCGCTACGACAGCGAAAAAAATT

TATTTTGTTTTACTTTCGACTACAATAACTTTATTACTCAGAACACTGTCATGTCAA A

GAGTTCGTGGAGTGTCTACACGTACGGAGTACGTATTAAGCGCCGTTTCGTCAACGG

ACGCTTCTCAAACGAAAGCGACACGATCGACATCACCAAAGACATGGAAAAAACTC

TTGAGATGACGGATATCAATTGGCGCGACGGCCATGACCTGCGTCAGGATATCATTG

ATTACGAGATCGTTCAGCACATCTTCGAAATCTTCCGCCTTACCGTCCAGATGCGCA

ACAGTTTAAGCGAGCTTGAAGACCGCGACTACGATCGTTTGATTAGCCCCGTTCTGA

ACGAGAATAATATTTTCTACGACAGCGCAAAGGCCGGTGATGCTTTGCCAAAGGAC

GCAGACGCGAATGGAGCCTACTGCATCGCCCTGAAGGGCTTATATGAGATTAAGCA

AATTACCGAAAATTGGAAGGAAGATGGTAAGTTCTCCCGTGATAAGCTTAAAATTA

GCAATAAGGATTGGTTCGACTTCATCCAGAACAAACGTTACCTGAAACGTCCGGCA

GCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAG

GCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTAT

TCCGGGCTAA

[0096] SEQ ID NO: 51 ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGAACAAACAATTTCCAAAACTTCATCGGTATCTCTTCGTTGCAGAAGACTCT

GCGTAATGCTTTGATCCCGACGGAGACAACCCAACAATTTATCGTCAAAAACGGTAT

TATTAAGGAGGACGAGTTACGTGGAGAAAATCGTCAAATCCTTAAGGACATCATGG

ACGATTATTATCGCGGGTTTATTTCTGAAACCCTGAGCAGTATCGATGATATCGACT

GGACCTCACTTTTTGAGAAAATGGAGATCCAGTTGAAGAACGGTGATAACAAAGAC

ACTCTGATCAAAGAGCAAACTGAATACCGCAAGGCAATTCACAAAAAGTTCGCCAA

CGACGACCGTTTCAAGAATATGTTCTCAGCTAAGTTAATCAGCGACATTTTGCCAGA

GTTCGTTATCCACAACAATAATTATAGTGCTTCAGAGAAGGAGGAAAAAACCCAAG

TGATTAAACTTTTTTCGCGCTTTGCAACCTCATTCAAGGACTACTTCAAGAATCGCG C

GAATTGCTTCAGTGCGGACGACATTTCTTCTTCAAGTTGCCATCGTATCGTTAACGA T

AACGCGGAAATTTTCTTCTCTAATGCTTTGGTGTATCGCCGCATTGTAAAATCGCTT A

GTAACGATGACATTAATAAGATCTCAGGTGATATGAAAGATTCATTGAAGGAAATG

AGCTTGGAAGAGATTTACAGTTACGAAAAATATGGAGAATTTATTACTCAGGAAGG

CATCTCATTCTATAACGATATCTGCGGGAAGGTAAATTCGTTTATGAACTTATATTG C

CAGAAAAATAAAGAGAATAAAAATTTGTATAAGCTTCAGAAGTTGCACAAACAGAT

CCTGTGCATTGCAGACACCTCGTATGAGGTTCCGTATAAATTTGAGTCCGATGAAGA

AGTGTATCAGTCTGTGAATGGTTTCTTAGATAATATCTCTTCCAAGCATATTGTCGA A

CGCCTGCGCAAAATTGGTGATAACTATAACGGATACAATCTGGATAAAATTTACATC

GTTTCTAAATTTTACGAGTCAGTCTCGCAGAAGACCTACCGCGACTGGGAAACAATT

AACACGGCATTGGAGATTCACTACAATAATATCTTGCCTGGTAACGGTAAGTCTAAG

GCAGATAAGGTAAAAAAAGCTGTGAAAAACGACCTTCAGAAAAGCATCACGGAGA

TTAATGAGCTGGTGAGTAATTACAAATTATGTTCAGACGATAATATTAAAGCTGAAA

CGTATATCCATGAAATCTCGCATATCTTGAACAACTTCGAGGCCCAAGAACTTAAAT

ATAACCCCGAAATCCATTTAGTCGAGTCTGAATTGAAAGCGTCGGAATTAAAAAAC

GTCTTAGACGTCATTATGAACGCGTTTCACTGGTGTTCAGTTTTCATGACCGAAGAG

CTGGTCGACAAAGACAACAACTTCTATGCGGAATTGGAGGAAATCTATGATGAAAT

CTACCCTGTTATTTCACTGTATAACCTTGTGCGCAACTATGTCACTCAGAAGCCGTA T

TCGACCAAAAAAATTAAATTGAATTTCGGTATCCCTACTCTTGCAGACGGATGGAGT

AAAAGCAAGGAATACAGTAATAACGCCATTATTCTTATGCGCGACAATTTATACTAC

CTGGGCATCTTTAACGCAAAGAATAAGCCGGATAAGAAGATTATTGAGGGTAACAC

CAGTGAGAACAAGGGCGACTATAAGAAGATGATCTATAACTTATTGCCAGGTCCAA

ATAAAATGATCCCAAAAGTATTCTTATCATCAAAGACGGGAGTTGAAACCTATAAG

CCTAGTGCCTATATTCTTGAGGGATATAAACAGAACAAGCACATTAAGTCGTCTAAG GATTTTGACATTACGTTCTGCCATGACTTAATCGACTATTTTAAAAACTGTATTGCGA

TTCACCCCGAATGGAAGAATTTTGGATTCGATTTTTCGGATACCTCGACCTATGAAG

ATATTTCGGGATTTTATCGTGAAGTGGAGTTGCAAGGCTATAAAATCGATTGGACCT

ATATCTCAGAAAAAGACATTGATTTATTACAGGAAAAGGGACAACTGTACCTTTTCC

AAATTTATAACAAGGACTTTTCTAAAAAGTCCACAGGAAATGATAACCTTCACACCA

TGTACCTGAAGAACCTTTTCTCAGAGGAAAACCTGAAGGACATTGTCCTTAAGTTAA

ATGGAGAAGCGGAGATCTTTTTCCGTAAATCTAGTATCAAGAATCCGATTATCCATA

AAAAAGGTTCGATTTTGGTAAATCGCACCTATGAAGCGGAAGAGAAAGATCAATTT

GGTAACATCCAGATCGTGCGCAAGAATATCCCGGAGAACATTTACCAAGAGCTGTA

TAAGTACTTCAATGATAAGTCTGATAAGGAACTGTCAGATGAAGCTGCGAAATTGA

AGAACGTGGTTGGGCATCATGAAGCCGCTACCAATATCGTCAAGGATTACCGTTATA

CCTATGACAAATATTTCTTACACATGCCGATTACGATCAATTTTAAGGCAAACAAGA

CAGGATTCATCAACGACCGTATCTTGCAGTATATTGCCAAAGAGAAGGATCTGCATG

TGATCGGTATTGACCGCGGGGAGCGCAATTTAATCTATGTATCGGTGATCGATACTT

GTGGTAACATCGTAGAACAAAAGAGCTTTAACATCGTGAATGGTTACGACTATCAG

ATCAAGCTGAAACAACAGGAAGGAGCCCGCCAGATCGCTCGCAAGGAATGGAAAG

AAATCGGGAAAATTAAGGAAATCAAGGAAGGCTACCTTTCATTGGTCATTCACGAA

ATTTCGAAAATGGTAATTAAGTACAACGCGATCATCGCCATGGAGGACCTTTCGTAC

GGATTTAAGAAGGGTCGTTTCAAAGTTGAGCGCCAGGTATACCAAAAATTCGAGAC

TATGCTTATCAACAAACTTAACTACTTGGTCTTTAAGGACATTTCTATTACCGAAAA C

GGCGGCTTACTTAAAGGCTATCAATTGACATATATTCCCGACAAACTGAAGAATGTT

GGACATCAATGCGGGTGTATTTTCTATGTGCCGGCAGCTTACACTAGTAAGATCGAC

CCTACAACCGGGTTCGTAAACATTTTTAAATTCAAAGACTTAACAGTCGATGCGAAG

CGTGAATTTATTAAGAAGTTTGATAGTATCCGCTATGACAGTGAAAAGAACTTGTTT

TGCTTTACGTTCGACTACAATAACTTTATTACACAGAACACGGTCATGTCTAAATCA

TCATGGTCGGTTTACACATATGGGGTGCGCATCAAGCGTCGCTTTGTAAATGGCCGT

TTTAGTAATGAGAGCGACACAATCGACATCACAAAGGATATGGAGAAAACTCTTGA

GATGACAGACATCAATTGGCGTGACGGTCATGACTTACGCCAAGATATCATCGACTA

CGAAATCGTACAGCATATTTTTGAGATTTTTCGTCTTACTGTGCAAATGCGTAATTC T

TTATCCGAACTGGAAGATCGTGATTACGACCGCTTGATTAGTCCCGTCTTAAATGAG

AACAATATTTTCTATGATTCTGCGAAAGCCGGAGATGCACTGCCCAAAGACGCTGAT

GCCAATGGCGCGTATTGCATTGCATTAAAAGGATTATATGAGATTAAACAGATTACC

GAAAATTGGAAAGAGGACGGTAAATTCTCACGCGATAAATTGAAGATTTCTAACAA

GGACTGGTTCGACTTTATCCAAAATAAACGTTATCTTAAACGTCCGGCAGCGACCAA

AAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCG AAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTA

A

[0097] SEQ ID NO: 52

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAACGGTACCAACAACTTTCAGAATTTCATTGGCATTAGCTCGCTTCAAAAAACTTT

ACGCAATGCTCTTATTCCGACTGAGACGACACAACAGTTTATCGTTAAGAATGGCAT

CATCAAAGAAGATGAATTACGCGGAGAAAACCGCCAGATCCTGAAAGACATTATGG

ACGATTATTACCGTGGGTTCATCTCCGAGACGTTGTCATCGATCGATGACATCGACT

GGACGTCACTTTTTGAAAAAATGGAGATCCAGTTAAAGAACGGTGACAATAAGGAT

ACATTGATCAAAGAACAGACCGAGTACCGTAAAGCGATTCATAAAAAGTTTGCGAA

CGATGATCGCTTCAAGAATATGTTTTCTGCGAAATTAATTTCCGACATTTTACCTGA A

TTTGTTATTCATAATAACAACTACTCGGCGTCTGAGAAAGAGGAGAAAACCCAAGT

GATTAAACTTTTTTCACGTTTCGCAACGTCGTTCAAAGACTATTTTAAAAATCGTGC T

AATTGCTTTAGCGCGGATGACATCAGCTCTAGTTCATGTCATCGCATTGTCAACGAT

AATGCTGAGATCTTTTTCAGTAATGCGTTAGTGTACCGTCGTATTGTGAAGTCCTTA T

CTAATGATGATATCAATAAGATCAGCGGGGATATGAAGGACTCACTTAAGGAGATG

AGCTTGGAGGAAATCTATTCCTATGAGAAGTATGGTGAGTTTATTACGCAAGAAGG

AATTAGCTTTTACAACGATATCTGTGGAAAGGTGAATTCGTTTATGAATTTGTATTG C

CAGAAAAATAAGGAGAACAAGAACCTTTATAAATTGCAAAAGTTACACAAGCAAAT

CCTGTGCATTGCAGATACTTCCTACGAGGTGCCTTACAAGTTTGAATCCGACGAAGA

GGTCTACCAATCTGTAAACGGTTTCTTAGATAATATTAGTTCCAAGCATATTGTGGA

GCGCCTTCGTAAAATTGGCGATAATTACAACGGTTACAATTTAGACAAAATTTACAT

TGTCAGTAAATTCTACGAGTCCGTATCTCAAAAGACGTATCGTGATTGGGAGACTAT

CAATACGGCCCTGGAGATCCACTACAACAATATCTTGCCCGGTAATGGTAAGTCGAA

GGCCGATAAAGTTAAGAAAGCGGTGAAAAATGACTTACAGAAGTCAATCACCGAAA

TTAACGAATTGGTGTCCAATTATAAATTGTGTTCAGATGATAATATCAAAGCCGAGA

CCTACATTCATGAGATTTCCCATATCTTAAATAATTTCGAGGCGCAAGAGCTTAAGT

ATAACCCAGAAATCCACCTGGTAGAATCTGAGTTGAAGGCGTCAGAGTTAAAAAAT

GTTTTAGATGTCATTATGAACGCGTTTCACTGGTGCTCCGTATTTATGACGGAGGAA

TTAGTAGATAAAGACAACAATTTCTATGCCGAACTTGAGGAAATCTATGATGAGATC

TATCCCGTCATTAGCCTGTATAACTTGGTCCGCAACTATGTTACCCAAAAACCGTAC

AGTACCAAGAAGATTAAGCTGAATTTCGGCATTCCTACACTGGCTGATGGTTGGAGT

AAATCGAAGGAATATTCGAATAACGCGATTATCTTGATGCGCGACAACTTATACTAT

TTGGGGATCTTTAACGCCAAAAACAAACCGGATAAGAAGATTATTGAGGGAAACAC ATCAGAGAACAAAGGCGACTACAAAAAAATGATTTACAACTTGTTACCGGGGCCTA

ACAAAATGATCCCGAAGGTGTTCTTATCCAGTAAAACAGGCGTTGAGACCTACAAA

CCTTCCGCATACATCCTGGAAGGGTATAAGCAGAACAAGCACATTAAGTCCAGCAA

GGATTTCGATATTACCTTCTGTCATGATTTAATTGACTATTTCAAGAACTGTATTGC A

ATCCACCCCGAGTGGAAGAACTTCGGATTCGACTTCTCAGATACGAGCACATATGAG

GACATCTCGGGGTTCTATCGTGAAGTAGAACTGCAGGGATATAAAATTGATTGGAC

ATATATTTCCGAAAAAGACATCGACCTTTTACAAGAGAAGGGTCAACTTTACTTGTT

CCAAATTTACAATAAAGACTTCTCAAAAAAAAGCACGGGTAACGATAATTTACACA

CTATGTATTTAAAGAACCTTTTCTCGGAAGAGAATTTAAAGGATATCGTATTGAAGT

TGAATGGAGAAGCGGAGATCTTCTTCCGTAAGTCCAGTATTAAAAACCCTATTATTC

ACAAGAAGGGATCGATTTTAGTTAACCGCACATACGAGGCCGAAGAGAAGGACCAA

TTTGGGAACATTCAAATTGTCCGCAAAAACATCCCTGAGAACATTTATCAAGAGCTT

TATAAGTACTTTAACGATAAGTCCGATAAGGAATTGTCAGATGAGGCGGCAAAGTT

GAAGAATGTCGTGGGGCATCATGAAGCTGCCACCAACATTGTGAAGGACTACCGCT

ACACTTACGACAAATACTTCCTGCACATGCCCATTACGATCAATTTTAAGGCCAATA

AGACAGGCTTTATTAACGACCGTATTCTTCAATATATCGCTAAGGAGAAGGACCTTC

ATGTGATTGGGATCGACCGCGGAGAACGTAATTTAATTTATGTGTCCGTCATCGATA

CGTGTGGAAATATCGTGGAACAGAAATCATTCAATATCGTGAATGGCTATGATTACC

AGATCAAATTAAAACAGCAGGAGGGCGCTCGCCAAATTGCGCGTAAGGAATGGAAA

GAGATCGGAAAAATCAAAGAAATCAAAGAAGGATATTTGTCATTGGTGATCCATGA

GATTTCAAAAATGGTAATTAAATATAATGCAATTATCGCAATGGAAGACCTGTCCTA

TGGTTTTAAGAAGGGTCGTTTCAAGGTAGAACGCCAAGTGTATCAAAAGTTCGAGA

CGATGCTGATCAATAAGCTGAATTATCTTGTGTTTAAGGACATTAGCATCACGGAAA

ATGGAGGGCTGTTGAAAGGCTATCAACTGACGTATATCCCTGACAAGCTGAAAAAT

GTTGGCCATCAGTGCGGGTGCATTTTCTACGTCCCCGCGGCGTATACAAGCAAGATC

GATCCTACTACGGGATTCGTAAATATTTTTAAATTCAAAGACTTAACCGTGGACGCC

AAGCGCGAATTCATTAAGAAGTTTGATAGCATTCGCTACGATTCAGAAAAAAATCTT

TTCTGTTTTACGTTCGATTACAACAATTTTATCACCCAGAACACAGTGATGAGCAAG

TCATCCTGGTCTGTCTATACCTACGGTGTCCGTATCAAACGCCGCTTCGTCAACGGA

CGCTTCTCTAATGAATCTGATACCATTGACATCACCAAGGACATGGAAAAGACACTT

GAGATGACAGATATTAACTGGCGTGACGGACATGACCTGCGTCAGGACATCATCGA

TTATGAGATTGTTCAGCATATCTTCGAGATCTTCCGCCTGACAGTACAAATGCGCAA

TTCACTGTCAGAACTTGAAGACCGCGACTATGACCGCCTGATCTCTCCAGTATTAAA

TGAGAACAATATCTTTTATGACAGTGCTAAGGCCGGCGATGCCCTTCCGAAAGATGC

TGATGCTAACGGAGCTTATTGTATTGCATTAAAGGGTCTTTATGAGATCAAGCAAAT TACCGAGAATTGGAAGGAGGATGGCAAATTCTCGCGCGACAAACTGAAAATCAGTA

ACAAGGACTGGTTCGATTTTATTCAGAATAAACGTTACCTGAAACGTCCGGCAGCGA

CCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAG

CCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0098] SEQ ID NO: 53

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAACGGAACGAACAACTTCCAGAACTTCATCGGCATCAGTTCTTTACAAAAAACCCT

GCGTAACGCCCTTATTCCGACTGAGACAACACAACAGTTCATCGTTAAAAACGGAAT

TATCAAAGAGGACGAGTTGCGCGGCGAGAATCGCCAAATTTTGAAAGATATTATGG

ACGACTATTATCGTGGTTTTATTTCAGAAACACTGAGTTCGATTGACGATATCGATT

GGACGAGCCTGTTTGAGAAAATGGAAATCCAGTTGAAAAATGGCGATAATAAAGAC

ACTTTAATCAAAGAACAAACCGAGTATCGTAAAGCGATCCATAAAAAGTTCGCTAA

TGACGATCGTTTTAAGAATATGTTCAGTGCGAAACTGATTTCAGACATTTTGCCCGA

GTTCGTGATCCATAATAACAACTATTCCGCCTCGGAAAAGGAAGAAAAAACCCAGG

TGATTAAGCTGTTCAGTCGCTTCGCAACATCTTTCAAGGATTATTTCAAGAATCGCG

CGAATTGCTTCAGTGCGGACGATATTTCTAGTTCAAGCTGCCATCGTATCGTTAATG

ATAACGCGGAGATTTTTTTTAGCAATGCTCTGGTGTACCGCCGCATTGTTAAGTCAC T

GTCCAACGATGATATTAACAAGATCTCAGGAGACATGAAAGACTCGCTTAAAGAGA

TGAGTCTGGAAGAGATCTATTCTTATGAGAAGTATGGCGAGTTTATTACCCAAGAAG

GAATCTCATTCTACAATGATATTTGTGGAAAGGTGAACAGCTTTATGAATCTTTACT

GCCAAAAAAACAAGGAGAATAAGAATCTTTACAAACTTCAGAAGTTACATAAACAG

ATTTTGTGTATTGCGGATACGTCTTATGAAGTCCCCTACAAATTTGAATCGGATGAA

GAGGTATACCAAAGTGTGAACGGATTCTTGGACAATATTTCTTCTAAACATATTGTT

GAACGCTTACGTAAGATCGGGGATAACTACAATGGCTACAATCTTGACAAAATCTA

CATTGTTAGCAAATTCTACGAGAGTGTCAGCCAAAAGACGTACCGCGATTGGGAAA

CAATTAATACTGCGCTTGAGATTCACTATAATAACATTTTACCAGGCAACGGCAAGT

CCAAGGCGGATAAAGTTAAAAAAGCTGTTAAAAACGATTTGCAAAAATCTATCACA

GAAATTAACGAGTTAGTTAGTAACTACAAACTGTGCTCCGATGACAACATTAAGGCT

GAGACGTATATCCATGAGATCTCTCACATCTTAAACAATTTTGAAGCTCAAGAACTT

AAGTACAATCCGGAAATCCACCTGGTGGAATCCGAGCTGAAGGCTAGCGAACTGAA

GAACGTATTGGACGTGATCATGAACGCGTTCCACTGGTGTTCTGTCTTTATGACGGA

AGAGCTTGTCGACAAAGATAATAACTTTTACGCGGAACTTGAGGAAATTTACGATG

AGATTTACCCAGTTATTTCATTGTATAACCTTGTCCGTAATTACGTGACCCAAAAGC C TTATAGTACGAAAAAAATCAAATTAAATTTTGGAATCCCAACACTGGCTGACGGTTG

GAGCAAATCTAAGGAGTATTCTAATAACGCAATCATCTTAATGCGTGACAACCTGTA

TTATTTGGGTATCTTCAATGCCAAAAATAAGCCTGACAAAAAGATTATCGAAGGAA

ATACTTCGGAGAATAAGGGGGATTACAAAAAAATGATTTACAATTTGCTGCCCGGG

CCGAACAAGATGATCCCCAAAGTGTTCTTATCCTCGAAGACTGGTGTAGAAACATAC

AAGCCAAGCGCATACATTCTGGAGGGTTACAAGCAAAACAAACACATCAAATCTTC

AAAAGACTTTGACATTACATTTTGCCATGATCTTATTGACTACTTCAAAAACTGCAT T

GCTATTCACCCCGAGTGGAAGAACTTTGGGTTTGACTTCAGCGACACGTCTACGTAT

GAGGACATCTCCGGGTTCTACCGTGAAGTTGAGTTACAAGGGTATAAGATTGACTGG

ACGTATATTTCAGAGAAAGATATCGATCTTTTGCAGGAAAAGGGCCAGTTATATTTA

TTCCAGATTTACAACAAGGACTTTAGTAAGAAGTCAACAGGAAATGACAACTTGCA

TACGATGTATTTGAAAAATCTTTTTTCTGAGGAAAATCTTAAGGACATCGTACTGAA

ATTGAATGGCGAGGCTGAAATCTTCTTCCGTAAATCCTCCATTAAGAATCCCATTAT

CCACAAAAAGGGGTCTATCCTGGTGAATCGTACCTACGAGGCAGAGGAGAAGGATC

AATTCGGAAATATTCAGATTGTTCGTAAGAACATCCCCGAGAACATTTATCAAGAAT

TGTATAAGTACTTTAATGACAAATCTGACAAAGAGTTATCCGACGAAGCTGCGAAA

CTGAAAAACGTTGTTGGTCACCACGAGGCCGCCACTAATATCGTAAAAGACTACCGT

TATACCTATGACAAGTACTTTTTGCACATGCCGATCACTATCAACTTCAAGGCGAAT

AAGACGGGCTTCATTAACGATCGTATCCTGCAATACATCGCCAAGGAGAAGGACCT

TCACGTCATTGGGATTGACCGTGGTGAGCGTAACCTGATTTATGTAAGCGTCATTGA

TACCTGCGGTAATATCGTCGAACAGAAAAGTTTCAACATTGTAAATGGATATGACTA

TCAGATCAAACTTAAGCAGCAGGAGGGTGCACGCCAGATTGCCCGCAAGGAATGGA

AGGAGATTGGGAAGATTAAGGAAATTAAAGAAGGTTACTTATCACTGGTTATTCAC

GAGATCAGTAAAATGGTAATCAAATATAACGCGATCATTGCCATGGAGGATCTGAG

CTATGGCTTTAAAAAGGGCCGTTTCAAAGTCGAGCGCCAGGTATATCAAAAGTTTGA

AACAATGCTGATTAACAAATTAAACTATCTGGTTTTCAAAGATATTTCGATCACTGA

AAATGGCGGGCTGTTGAAGGGATACCAACTTACATACATCCCTGACAAACTGAAAA

ATGTCGGTCACCAATGTGGATGTATCTTTTATGTACCAGCAGCGTATACGAGCAAAA

TCGATCCAACTACGGGTTTTGTGAACATCTTTAAGTTCAAGGATTTGACAGTAGATG

CCAAACGCGAGTTCATTAAAAAATTTGATTCAATTCGCTACGATTCAGAGAAAAATC

TTTTTTGTTTCACGTTCGATTACAATAATTTCATTACGCAGAACACAGTAATGTCAA A

GTCAAGCTGGTCGGTCTACACGTATGGAGTCCGTATTAAACGTCGTTTTGTAAACGG

CCGTTTCTCAAATGAATCAGATACAATTGATATTACGAAGGATATGGAGAAGACATT

AGAGATGACTGACATTAACTGGCGCGACGGACATGATCTTCGTCAGGACATTATTGA

TTATGAGATTGTACAGCATATCTTTGAGATCTTCCGCCTGACCGTTCAGATGCGCAA TTCGTTGTCCGAGTTAGAAGACCGCGATTACGACCGTTTAATCAGTCCCGTCTTAAA

CGAAAATAACATCTTCTACGATTCAGCCAAGGCAGGCGATGCCTTGCCAAAGGATG

CTGACGCAAATGGCGCATACTGTATTGCGTTGAAAGGCCTTTATGAAATCAAGCAAA

TTACCGAAAACTGGAAAGAAGACGGAAAATTCTCCCGTGATAAGTTGAAAATCTCT

AATAAGGATTGGTTCGATTTCATCCAAAATAAACGCTATTTGAAACGTCCGGCAGCG

ACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCA

GCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCG

GGCTAA

[0099] SEQ ID NO: 54

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGAACTAATAATTTCCAAAATTTTATAGGCATCTCTTCTTTACAGAAGACTCT T

CGTAACGCCCTAATCCCGACTGAGACCACACAACAATTCATAGTGAAAAATGGGAT

CATTAAAGAAGACGAGCTGCGTGGGGAGAACAGGCAGATCCTAAAAGACATAATG

GACGATTATTATAGAGGGTTCATCTCAGAGACATTATCTAGCATCGACGACATTGAC

TGGACCTCCCTGTTTGAAAAAATGGAAATCCAGCTGAAGAATGGTGACAATAAAGA

CACATTAATAAAAGAACAAACAGAGTACAGGAAAGCCATCCACAAGAAGTTCGCAA

ACGATGACAGATTCAAAAATATGTTCAGTGCGAAGCTAATATCCGACATCTTACCAG

AGTTTGTAATACACAATAACAATTACAGCGCGAGCGAAAAGGAAGAGAAAACGCA

AGTAATTAAGCTTTTTAGTAGGTTCGCTACCTCTTTCAAAGATTACTTCAAAAATCG T

GCTAACTGCTTCTCAGCCGACGACATATCTTCAAGTTCCTGTCACCGTATCGTGAAT

GATAACGCTGAGATATTCTTCTCAAACGCCCTTGTATACCGTAGGATCGTAAAGTCC

TTATCTAACGATGATATAAACAAGATCAGTGGAGACATGAAAGACAGCCTTAAAGA

GATGTCTCTAGAAGAAATTTACTCCTATGAAAAGTATGGGGAGTTTATAACACAGGA

GGGGATCAGCTTCTACAACGACATCTGCGGAAAGGTGAACAGTTTCATGAATCTTTA

CTGCCAGAAGAATAAAGAGAACAAAAATCTTTATAAGCTTCAAAAGTTGCACAAAC

AAATACTGTGCATTGCCGATACATCATATGAGGTCCCCTATAAGTTCGAATCTGATG

AGGAAGTTTATCAATCTGTTAACGGCTTTCTAGACAATATCAGCTCAAAACACATCG

TAGAAAGACTGAGGAAAATAGGTGATAATTATAATGGATACAACTTGGATAAAATA

TATATAGTCTCTAAATTTTACGAGTCAGTATCCCAGAAAACGTATAGGGATTGGGAG

ACCATCAACACGGCGTTAGAGATTCATTACAATAACATCTTACCGGGAAACGGAAA

AAGTAAGGCGGACAAAGTAAAGAAAGCCGTTAAAAATGACTTACAAAAGAGTATA

ACAGAAATAAACGAACTAGTAAGCAACTACAAGCTTTGTTCCGATGATAATATCAA

GGCCGAGACATATATCCATGAGATCTCCCACATTCTAAACAATTTCGAAGCGCAAGA

ACTTAAATATAATCCCGAAATCCACCTGGTGGAAAGTGAACTAAAGGCTAGTGAGT TAAAGAACGTTCTTGATGTTATCATGAACGCCTTCCATTGGTGCTCTGTTTTTATGAC

CGAGGAGTTGGTTGATAAAGATAATAATTTCTACGCTGAATTAGAGGAGATATACG

ACGAAATCTACCCAGTGATTTCACTATACAACTTGGTCAGGAACTATGTTACACAAA

AGCCGTACAGCACTAAGAAAATTAAGCTAAATTTCGGTATCCCCACGTTAGCCGACG

GGTGGAGCAAGTCCAAAGAATATTCCAACAATGCGATTATTTTAATGCGTGACAATC

TTTATTACCTTGGCATCTTCAATGCCAAAAACAAACCTGACAAAAAGATTATAGAAG

GTAATACGTCCGAGAACAAAGGCGATTACAAGAAGATGATTTATAACCTACTGCCC

GGACCAAACAAAATGATCCCCAAAGTTTTTCTTAGTTCTAAAACCGGCGTAGAGACG

TATAAACCTTCTGCCTATATCTTAGAGGGATATAAGCAGAACAAACATATCAAATCT

TCCAAGGACTTTGATATTACATTCTGCCACGATTTAATTGACTACTTCAAAAATTGC A

TAGCGATACATCCGGAGTGGAAGAACTTTGGCTTCGACTTCAGTGATACATCCACCT

ATGAGGATATATCAGGCTTCTATCGTGAGGTCGAATTGCAAGGGTACAAAATCGATT

GGACGTATATATCCGAGAAAGACATAGACCTTCTTCAAGAAAAGGGGCAGTTATAT

TTATTCCAAATATACAACAAGGACTTCAGTAAGAAGTCAACAGGTAATGACAACTT

ACACACCATGTACTTGAAAAATTTATTTTCTGAAGAAAACCTAAAGGACATTGTACT

AAAACTGAACGGGGAGGCAGAAATTTTTTTTAGAAAGAGCAGCATAAAAAACCCAA

TAATTCATAAGAAAGGAAGCATTTTAGTTAATAGGACGTACGAGGCAGAGGAAAAG

GACCAGTTTGGCAATATCCAGATCGTAAGGAAAAATATTCCTGAAAACATATATCA

GGAACTATATAAATACTTTAACGACAAATCCGACAAAGAATTATCCGACGAGGCTG

CAAAGCTGAAGAACGTCGTAGGGCACCATGAGGCAGCGACTAATATTGTGAAAGAC

TATAGGTATACATACGACAAATACTTTCTGCACATGCCCATCACGATTAACTTCAAG

GCGAACAAGACGGGATTCATTAACGACCGTATATTACAATATATTGCTAAGGAGAA

AGATCTGCATGTAATAGGTATCGACAGAGGCGAACGTAATTTAATCTACGTGTCCGT

CATCGACACGTGCGGGAACATCGTAGAGCAAAAGAGTTTTAATATAGTAAATGGCT

ATGATTACCAAATTAAGCTAAAGCAGCAAGAAGGAGCAAGACAGATAGCTAGGAA

AGAATGGAAGGAGATAGGAAAAATAAAGGAGATCAAGGAGGGGTATCTTAGCCTA

GTAATTCATGAAATATCTAAGATGGTTATCAAATACAACGCTATCATAGCGATGGAA

GACTTATCTTATGGTTTCAAGAAAGGAAGGTTCAAAGTAGAGCGTCAAGTTTATCAA

AAGTTCGAAACGATGTTGATTAATAAACTAAACTATTTGGTATTTAAAGATATATCT

ATCACCGAGAATGGTGGTCTACTAAAGGGTTACCAGCTTACATACATACCGGACAA

ACTTAAAAACGTCGGACATCAGTGTGGATGCATTTTCTACGTTCCAGCTGCATATAC

CAGCAAGATCGACCCAACGACTGGGTTCGTAAATATTTTTAAATTCAAGGATTTGAC

TGTCGACGCCAAAAGAGAGTTCATAAAAAAGTTCGATTCAATTAGGTACGACAGCG

AAAAGAATTTGTTCTGCTTTACTTTTGACTATAACAATTTCATTACTCAGAACACTG T

AATGTCTAAGTCCTCTTGGTCAGTCTATACTTATGGCGTTCGTATCAAACGTAGATT T GTTAACGGTAGATTCTCAAATGAAAGTGATACAATAGATATCACGAAAGATATGGA

GAAAACATTAGAAATGACAGACATAAACTGGAGAGACGGACATGACTTGAGACAG

GACATTATTGACTACGAGATCGTGCAGCACATCTTTGAGATCTTTCGTTTGACCGTA

CAAATGCGTAACAGTTTATCTGAGCTTGAGGACAGGGACTACGATAGATTGATATCA

CCTGTATTAAATGAGAATAACATCTTCTATGATTCCGCAAAAGCAGGCGACGCTCTA

CCCAAAGACGCTGATGCGAACGGTGCTTATTGCATAGCTTTAAAGGGTTTGTATGAG

ATCAAACAGATAACAGAAAATTGGAAGGAAGATGGTAAGTTCTCCCGTGACAAGCT

TAAAATATCAAATAAGGACTGGTTCGATTTTATACAGAATAAGCGTTATTAAAACGT

CCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCG

GCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAA

GGTTATTCCGGGCTAA

[0100] SEQ ID NO: 55

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAATGGAACTAATAACTTCCAGAATTTCATTGGTATCTCCTCTTTACAAAAAACTCT

AAGAAACGCCCTAATTCCGACTGAAACTACACAGCAATTCATCGTCAAAAACGGGA

TCATTAAGGAGGATGAGTTGAGGGGTGAAAATCGTCAAATTCTTAAAGACATCATG

GACGACTACTACAGGGGGTTCATCAGCGAGACGTTATCTAGTATAGACGATATAGA

CTGGACTTCACTGTTCGAGAAGATGGAAATCCAATTAAAAAATGGGGACAATAAAG

ATACACTTATAAAGGAACAGACAGAGTATAGAAAGGCAATACACAAAAAGTTTGCC

AACGACGATCGTTTCAAGAACATGTTTAGTGCTAAATTGATTTCAGATATTCTGCCG

GAATTTGTTATTCACAACAATAATTATAGCGCCAGTGAGAAAGAAGAAAAAACGCA

GGTTATCAAACTGTTCAGTCGTTTCGCTACATCTTTTAAGGATTACTTTAAAAACCG T

GCAAATTGTTTTTCAGCCGACGATATTAGTAGCAGCTCTTGTCACCGTATTGTTAAT G

ATAATGCGGAGATTTTCTTTTCAAACGCATTGGTCTACAGGAGGATAGTCAAGTCCC

TTTCAAATGACGACATTAATAAGATCTCAGGTGACATGAAAGATTCCTTAAAGGAA

ATGTCCCTGGAAGAGATCTATTCCTATGAAAAGTACGGTGAGTTCATTACTCAAGAG

GGTATAAGCTTTTACAATGACATATGTGGTAAGGTTAATAGCTTTATGAACCTGTAT

TGCCAGAAGAACAAAGAAAATAAGAATCTGTATAAGTTGCAAAAGCTACACAAACA

AATTTTGTGCATTGCCGATACATCATACGAGGTGCCATACAAATTCGAGAGCGATGA

GGAGGTTTATCAGAGCGTGAATGGATTCCTGGACAATATTAGTAGTAAGCATATCGT

GGAAAGGCTTAGAAAGATAGGTGACAATTACAATGGCTACAATCTGGATAAAATCT

ACATCGTCTCAAAATTCTATGAAAGTGTATCCCAGAAGACGTACCGTGATTGGGAAA

CTATCAACACCGCTCTGGAGATACATTACAACAATATACTTCCCGGAAACGGCAAGT

CAAAAGCCGACAAAGTCAAAAAAGCGGTCAAGAACGATTTACAAAAGTCTATCACT GAAATTAATGAATTAGTTAGTAATTACAAACTGTGTAGTGATGATAATATTAAGGCA

GAGACTTACATACACGAAATTTCACACATTTTAAACAACTTCGAGGCACAGGAACTT

AAATATAATCCTGAAATTCACCTGGTTGAAAGTGAATTGAAAGCCAGCGAGCTAAA

GAACGTTTTGGACGTAATCATGAACGCATTCCACTGGTGCTCTGTCTTTATGACAGA

GGAACTAGTGGATAAGGACAATAATTTTTATGCGGAGCTGGAGGAAATATACGATG

AGATATATCCCGTAATATCATTATATAATCTGGTAAGAAACTATGTGACTCAAAAGC

CGTATAGCACCAAGAAAATTAAACTTAATTTCGGCATACCCACTTTAGCGGACGGCT

GGTCAAAATCCAAAGAGTATAGTAATAATGCCATCATCCTGATGCGTGACAACCTGT

ACTATTTAGGTATATTTAACGCCAAAAATAAACCCGACAAAAAGATTATAGAGGGC

AACACCTCAGAGAACAAAGGTGATTATAAGAAGATGATTTACAACCTTTTACCCGGT

CCTAATAAGATGATTCCCAAAGTCTTTCTATCTAGCAAAACTGGTGTTGAAACATAC

AAACCCTCAGCTTATATTTTAGAAGGGTATAAGCAGAATAAGCATATTAAAAGCTCC

AAAGATTTCGATATTACCTTTTGCCATGACTTGATAGACTATTTCAAAAATTGTATT G

CCATTCACCCTGAATGGAAAAACTTCGGATTTGACTTCTCTGACACATCCACCTACG

AAGACATTTCAGGTTTTTACAGGGAAGTCGAGCTACAGGGTTATAAAATTGATTGGA

CATACATCAGCGAGAAAGATATTGACCTACTTCAAGAAAAAGGGCAGCTATACCTG

TTCCAGATATACAATAAAGACTTCAGTAAAAAAAGCACCGGGAACGATAATCTTCA

CACAATGTACTTAAAAAATTTATTTAGTGAAGAGAATCTGAAGGATATAGTGCTGAA

GTTAAACGGGGAGGCAGAGATATTTTTTAGAAAATCTAGTATTAAGAATCCGATCAT

CCACAAGAAGGGTTCTATCCTTGTTAATAGGACTTATGAGGCAGAAGAAAAAGACC

AATTCGGCAACATACAAATTGTCCGTAAAAATATCCCTGAGAACATTTATCAGGAAC

TATACAAGTACTTCAATGATAAAAGCGACAAGGAGCTGAGCGACGAGGCTGCTAAG

TTAAAGAATGTGGTGGGCCACCATGAGGCAGCAACGAATATTGTGAAGGACTATCG

TTATACCTACGATAAATACTTTCTTCATATGCCGATCACCATTAATTTCAAGGCAAA C

AAAACTGGCTTCATTAACGATCGTATCTTACAATATATCGCAAAAGAGAAAGACCTT

CACGTTATCGGGATCGATAGAGGCGAGCGTAACCTAATTTATGTTTCTGTGATAGAC

ACCTGTGGGAACATAGTCGAACAGAAATCATTTAATATTGTTAACGGCTACGATTAT

CAGATAAAGTTGAAGCAACAAGAGGGTGCACGTCAAATAGCAAGGAAAGAATGGA

AAGAAATAGGCAAGATTAAAGAAATAAAAGAAGGTTATTTATCCCTTGTAATACAC

GAAATTAGCAAAATGGTGATTAAATATAATGCGATCATTGCCATGGAGGATCTTTCT

TACGGCTTCAAAAAGGGGAGATTCAAAGTCGAGAGGCAGGTGTATCAGAAGTTTGA

GACCATGCTAATCAATAAACTAAATTATCTAGTATTCAAAGACATAAGCATCACCGA

AAATGGCGGCTTGTTGAAGGGTTATCAATTGACCTACATCCCAGATAAACTAAAAA

ACGTAGGGCATCAATGCGGATGTATATTTTACGTTCCAGCCGCATACACTTCCAAAA

TCGATCCAACTACGGGTTTTGTGAACATCTTCAAATTCAAAGACTTGACTGTCGATG CTAAGAGGGAGTTTATCAAGAAATTTGACTCCATTAGATACGACAGTGAGAAGAAT

CTGTTCTGTTTTACCTTTGATTATAACAACTTTATAACTCAAAACACAGTCATGAGT A

AGTCATCTTGGTCAGTGTATACGTATGGTGTGAGGATTAAAAGGAGGTTTGTTAACG

GGAGATTTTCCAATGAAAGTGATACAATAGATATAACCAAGGACATGGAAAAGACT

CTTGAAATGACCGACATTAACTGGAGAGATGGCCACGACTTACGTCAAGATATAAT

CGATTACGAGATAGTGCAACATATCTTTGAGATATTTAGGCTTACTGTCCAAATGCG

TAACTCATTAAGTGAGTTGGAGGACAGGGATTACGATAGGCTAATAAGTCCTGTTCT

TAACGAAAACAATATATTCTACGATTCAGCAAAGGCGGGAGACGCCCTGCCCAAGG

ACGCGGATGCTAACGGCGCATACTGTATTGCCCTGAAAGGCTTGTACGAGATAAAA

CAGATCACGGAGAACTGGAAAGAAGATGGAAAATTCAGTCGTGACAAGTTAAAAAT

TAGTAACAAAGACTGGTTCGACTTTATTCAGAACAAGAGATATCTGAAACGTCCGGC

AGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCA

GGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTA

TTCCGGGCTAA

[0101] SEQ ID NO: 56

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAACGGAACCAATAACTTTCAAAACTTTATAGGCATCTCCAGTCTACAGAAGACACT

ACGTAACGCTTTGATACCAACTGAGACCACGCAGCAGTTTATCGTCAAGAACGGTAT

TATAAAGGAAGACGAGCTAAGGGGGGAAAACCGTCAGATCTTAAAGGACATCATGG

ATGACTACTACAGAGGCTTCATAAGTGAGACTTTGTCTAGTATAGACGACATCGACT

GGACCAGTTTATTTGAGAAGATGGAAATTCAGTTAAAGAACGGGGACAATAAAGAC

ACACTAATTAAAGAGCAGACCGAATACAGAAAAGCTATACACAAAAAGTTTGCCAA

CGATGATAGATTCAAAAATATGTTTTCAGCAAAATTGATTTCCGACATATTGCCAGA

ATTCGTAATCCATAATAACAATTATTCTGCAAGTGAGAAGGAAGAGAAGACCCAAG

TAATCAAGCTGTTTTCCCGTTTTGCTACGAGTTTCAAAGATTATTTCAAGAATAGGG C

TAATTGTTTCTCCGCGGACGACATAAGTAGCAGTTCCTGTCACAGGATTGTGAACGA

TAATGCTGAGATATTTTTTTCCAATGCCCTAGTGTATAGGAGAATAGTTAAAAGCTT

AAGCAACGACGATATCAATAAAATTTCAGGGGACATGAAGGACAGCTTAAAGGAAA

TGAGTTTGGAGGAGATTTACAGTTATGAAAAATACGGAGAGTTTATAACTCAGGAA

GGCATCTCTTTCTATAATGATATCTGTGGGAAGGTAAACTCCTTCATGAATTTATAT T

GCCAGAAGAATAAGGAAAACAAAAATCTTTACAAGCTTCAAAAGTTACATAAGCAG

ATCTTATGTATTGCCGACACGAGTTATGAAGTGCCTTATAAATTCGAGAGTGATGAG

GAAGTGTATCAGTCTGTTAACGGATTCCTAGATAATATAAGTTCCAAACATATAGTC

GAGAGGCTGAGGAAGATTGGCGATAACTATAATGGATATAATCTTGACAAAATCTA TATAGTCTCTAAATTTTATGAAAGCGTCAGCCAGAAGACATATAGAGATTGGGAAA

CTATAAACACAGCCCTTGAAATACATTACAATAACATCCTACCCGGCAATGGTAAGT

CTAAGGCAGACAAAGTTAAAAAAGCAGTAAAGAATGACTTACAGAAGTCAATCACG

GAGATAAATGAGTTGGTCAGTAACTACAAATTATGCTCCGACGATAATATTAAGGCC

GAAACATATATACACGAGATAAGTCATATATTAAACAATTTCGAAGCCCAGGAGTT

AAAATATAACCCTGAAATTCATCTGGTCGAAAGTGAGTTAAAGGCCAGTGAGTTAA

AGAATGTACTTGACGTAATTATGAATGCTTTTCATTGGTGCTCCGTGTTCATGACCG A

GGAGTTAGTAGATAAAGACAATAACTTTTACGCCGAACTTGAAGAGATATACGACG

AGATTTATCCGGTAATCAGCTTGTACAACTTAGTTAGAAATTATGTAACACAGAAGC

CTTACTCTACTAAAAAAATAAAACTGAACTTTGGTATCCCAACTCTTGCAGATGGTT

GGAGTAAAAGCAAGGAATATAGCAACAATGCGATCATCTTGATGAGAGACAACTTG

TACTATTTGGGAATCTTCAACGCGAAAAATAAACCCGACAAAAAAATCATCGAAGG

GAATACCTCTGAGAATAAAGGTGACTATAAGAAAATGATTTACAATCTACTTCCTGG

TCCTAATAAAATGATCCCGAAAGTGTTTCTTAGTTCTAAGACTGGTGTCGAGACGTA

CAAACCTAGCGCGTACATCTTAGAAGGGTACAAGCAGAATAAACACATCAAATCAA

GCAAAGACTTCGATATTACTTTTTGCCATGACTTGATAGACTACTTTAAAAACTGCA

TAGCAATCCACCCGGAGTGGAAAAACTTTGGCTTTGATTTCTCTGACACCTCTACAT

ATGAGGACATATCTGGTTTTTACCGTGAGGTTGAATTGCAGGGATACAAAATTGACT

GGACTTACATATCTGAAAAAGATATCGATCTATTGCAGGAGAAAGGCCAGCTTTACC

TTTTCCAGATCTATAATAAGGACTTCTCTAAGAAGTCTACAGGGAATGATAATTTGC

ACACTATGTACTTAAAAAATCTGTTTTCCGAGGAAAACTTGAAAGACATTGTTTTAA

AGTTGAACGGAGAAGCTGAAATATTTTTCAGAAAGAGCTCCATAAAAAACCCGATC

ATTCATAAGAAGGGATCTATCCTGGTTAACAGAACGTACGAAGCGGAAGAAAAAGA

CCAATTCGGAAACATTCAAATTGTTAGAAAGAATATCCCTGAGAACATCTACCAGG

AGTTATATAAGTATTTTAATGATAAGTCAGATAAGGAACTATCTGACGAAGCGGCG

AAGCTTAAAAATGTTGTAGGACACCATGAGGCTGCTACAAATATAGTCAAGGACTA

CCGTTATACCTACGATAAGTACTTTCTACACATGCCCATTACCATCAATTTTAAAGC T

AATAAAACGGGTTTTATCAACGATCGTATCCTACAATATATTGCGAAAGAGAAGGA

TTTGCATGTCATTGGCATTGATAGAGGTGAGAGGAACCTAATATACGTATCCGTGAT

TGATACGTGCGGGAACATAGTTGAACAGAAATCATTTAATATAGTTAATGGGTACG

ACTATCAGATTAAGCTAAAGCAACAAGAAGGCGCCAGGCAAATTGCCCGTAAAGAA

TGGAAAGAGATCGGGAAGATCAAGGAAATAAAAGAAGGATACCTTTCCCTGGTCAT

CCATGAAATTAGCAAAATGGTGATTAAGTACAATGCCATAATCGCGATGGAGGACT

TAAGCTACGGGTTCAAAAAGGGGAGGTTTAAGGTGGAGAGGCAAGTGTACCAGAAA

TTTGAGACCATGCTAATCAACAAACTGAACTACCTAGTTTTTAAGGACATTTCAATT ACAGAGAATGGAGGACTTTTAAAGGGTTACCAACTAACGTATATACCAGATAAGTT

GAAAAATGTCGGTCACCAGTGTGGCTGCATCTTTTACGTTCCCGCCGCTTATACATC T

AAAATTGATCCAACCACAGGCTTTGTAAATATCTTTAAATTCAAAGATTTAACTGTG

GATGCAAAAAGAGAGTTTATCAAGAAATTCGATAGCATTCGTTATGATAGCGAGAA

GAACCTGTTCTGCTTTACTTTCGACTATAACAACTTTATAACTCAAAACACCGTGAT G

TCAAAAAGCTCATGGTCAGTCTACACCTATGGTGTAAGGATTAAAAGGCGTTTCGTG

AATGGGAGATTCTCCAATGAAAGTGACACGATCGACATAACAAAGGACATGGAGAA

GACACTAGAGATGACTGATATTAATTGGAGAGACGGACACGATCTGCGTCAAGATA

TAATTGATTATGAGATAGTACAGCACATATTTGAGATCTTCCGTTTGACTGTCCAAA

TGCGTAATTCCCTTTCTGAGCTGGAAGATAGGGACTATGATAGATTAATATCCCCTG

TACTAAATGAGAACAACATTTTCTATGATAGTGCAAAAGCCGGGGATGCATTGCCG

AAAGACGCTGACGCTAATGGGGCGTACTGTATAGCTTTAAAGGGGCTTTACGAAAT

AAAGCAGATAACCGAAAACTGGAAGGAAGATGGCAAATTCTCAAGGGACAAACTT

AAGATCTCTAACAAGGATTGGTTCGATTTTATACAAAACAAACGTTATTTGAAACGT

CCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCG

GCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAA

GGTTATTCCGGGCTAA

[0102] SEQ ID NO: 57

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAATGGTACAAACAACTTTCAGAATTTCATTGGGATCTCTAGCTTACAGAAGACCCT

GAGGAATGCGTTGATTCCAACTGAAACAACCCAGCAATTCATCGTGAAAAATGGGA

TAATCAAAGAGGATGAGTTAAGGGGTGAAAACCGTCAAATATTGAAGGATATTATG

GACGACTACTACCGTGGATTCATCTCAGAGACGTTGAGCAGCATTGACGACATAGA

CTGGACTAGCCTTTTCGAGAAGATGGAAATTCAGTTAAAGAACGGAGATAACAAAG

ATACACTAATCAAGGAACAGACAGAATACAGAAAAGCAATTCATAAGAAATTCGCT

AATGACGATCGTTTTAAAAACATGTTCTCTGCAAAATTAATTAGCGACATTCTGCCG

GAATTCGTTATACATAATAATAACTACAGTGCTTCTGAAAAGGAAGAGAAAACTCA

GGTAATAAAACTGTTCTCTCGTTTTGCCACATCCTTCAAAGACTACTTTAAAAATAG

AGCGAACTGCTTTAGCGCCGACGATATTAGTTCTTCCTCATGCCACAGGATTGTCAA

CGATAATGCAGAGATATTCTTTTCTAACGCACTAGTCTACAGAAGGATTGTAAAGTC

TTTGTCAAATGATGACATAAACAAGATTAGTGGAGATATGAAAGACTCTCTAAAGG

AAATGAGCCTTGAGGAGATATACTCTTATGAAAAGTACGGTGAGTTTATTACCCAAG

AAGGCATTAGTTTCTATAATGACATTTGTGGAAAAGTTAACAGTTTTATGAATCTAT

ACTGTCAAAAAAATAAGGAGAATAAAAATCTTTATAAGTTGCAAAAACTGCATAAG CAGATATTATGTATAGCAGACACGAGCTATGAGGTACCGTACAAGTTCGAGAGCGA

TGAGGAAGTCTACCAATCTGTCAACGGATTTTTGGACAACATTTCTTCAAAACATAT

TGTGGAGAGGCTTAGGAAAATAGGCGACAATTATAATGGATATAACTTAGATAAGA

TATATATTGTTTCCAAATTCTACGAATCTGTAAGCCAGAAGACATACAGAGATTGGG

AAACGATAAACACAGCCCTTGAAATTCACTATAACAACATACTACCTGGAAACGGC

AAATCAAAGGCCGACAAAGTTAAGAAGGCCGTAAAGAATGATTTACAGAAGAGCAT

AACGGAGATCAATGAGCTGGTGTCTAACTATAAATTGTGTAGCGATGACAACATAA

AAGCCGAGACTTACATTCACGAAATTTCACACATACTTAACAACTTTGAAGCTCAGG

AATTAAAGTATAATCCCGAAATACACCTTGTGGAGTCCGAACTAAAGGCTAGTGAG

CTTAAGAACGTCCTAGACGTAATTATGAATGCCTTCCACTGGTGTAGTGTTTTTATG A

CCGAGGAACTTGTTGACAAAGATAATAATTTTTATGCAGAACTAGAAGAGATATAC

GATGAAATATACCCGGTGATCAGTTTGTACAATCTTGTCAGGAACTATGTGACACAA

AAGCCCTATTCAACAAAGAAAATAAAACTTAATTTCGGAATTCCTACGTTAGCTGAT

GGCTGGTCTAAATCCAAGGAATACAGCAACAACGCTATAATTCTGATGAGAGATAA

CTTGTACTATCTAGGCATCTTCAATGCCAAAAATAAGCCTGATAAGAAGATTATAGA

GGGCAACACTTCAGAGAACAAGGGCGACTACAAGAAAATGATCTATAACCTATTGC

CTGGCCCAAACAAGATGATTCCGAAGGTCTTCCTATCATCCAAGACCGGCGTTGAGA

CATACAAGCCATCAGCGTATATTTTAGAGGGGTACAAACAAAACAAGCACATAAAG

TCTAGTAAAGACTTCGATATAACATTTTGTCATGACTTAATTGACTACTTTAAGAAT T

GCATCGCTATACACCCGGAATGGAAGAATTTCGGCTTCGACTTCTCTGATACATCTA

CCTACGAGGACATTAGCGGGTTTTACCGTGAAGTCGAATTACAAGGGTATAAGATA

GATTGGACGTACATCTCTGAGAAAGACATAGACTTGCTTCAGGAAAAGGGCCAGTT

GTATCTATTCCAAATATACAATAAGGATTTTTCCAAGAAATCTACGGGTAATGACAA

TCTTCACACAATGTATCTTAAGAACCTTTTCTCAGAAGAGAACCTGAAGGACATTGT

CTTAAAACTAAATGGCGAAGCTGAGATTTTTTTCAGGAAGTCTTCAATTAAGAACCC

GATAATCCACAAGAAGGGGAGTATTCTTGTGAATAGAACTTACGAGGCCGAAGAAA

AAGACCAATTTGGTAACATCCAGATAGTCAGAAAGAACATTCCAGAGAACATCTAC

CAAGAGCTATACAAATATTTCAACGACAAGTCCGATAAGGAACTGTCCGATGAGGC

AGCCAAGTTGAAGAATGTCGTGGGTCATCATGAAGCTGCTACTAACATTGTCAAGG

ACTATCGTTATACTTACGACAAGTATTTCCTACACATGCCGATAACAATTAATTTCA

AGGCTAACAAAACAGGCTTTATCAACGATCGTATCTTGCAGTACATAGCTAAGGAA

AAGGATTTGCATGTGATTGGCATTGATAGAGGGGAGCGTAACTTGATATATGTGTCT

GTCATAGACACGTGTGGCAACATCGTCGAACAGAAATCATTCAACATAGTAAACGG

CTACGATTACCAAATTAAGCTGAAACAGCAAGAGGGTGCACGTCAAATTGCGCGTA

AAGAGTGGAAAGAAATTGGTAAAATCAAGGAAATTAAAGAAGGCTACTTGTCTCTT GTTATACATGAAATTTCCAAGATGGTTATAAAGTATAACGCGATAATTGCTATGGAA

GACTTATCATACGGGTTTAAAAAGGGGAGGTTCAAGGTAGAGAGGCAGGTCTATCA

AAAGTTCGAGACGATGTTGATTAATAAACTAAACTATCTAGTGTTCAAAGATATCAG

CATTACGGAGAACGGGGGGCTACTGAAAGGATATCAACTAACGTACATTCCCGATA

AGTTAAAGAACGTTGGTCATCAATGTGGTTGCATCTTCTACGTGCCTGCTGCCTATA

CGTCCAAAATAGATCCAACTACTGGATTTGTTAACATCTTTAAATTCAAAGATTTAA

CCGTAGACGCCAAAAGGGAATTTATAAAAAAATTTGACAGCATCCGTTACGATAGC

GAAAAGAATCTGTTCTGTTTTACTTTCGACTACAATAATTTCATCACGCAAAATACG

GTAATGTCTAAGTCAAGTTGGAGCGTCTACACGTATGGAGTCAGGATCAAGAGGCG

TTTCGTAAATGGAAGATTCTCTAATGAGTCAGATACTATAGACATCACGAAAGATAT

GGAGAAAACCTTGGAGATGACGGATATTAACTGGCGTGATGGACACGATTTAAGAC

AGGACATTATTGACTATGAGATTGTGCAACACATCTTCGAAATATTCCGTCTAACAG

TCCAAATGAGGAATAGCCTAAGTGAATTGGAGGACCGTGATTACGATAGGCTTATA

AGTCCTGTCCTTAACGAAAACAATATTTTCTATGATAGTGCTAAGGCGGGGGACGCA

CTGCCTAAAGACGCAGATGCTAACGGGGCATACTGCATTGCGTTAAAGGGTCTGTAC

GAAATCAAGCAGATTACGGAAAACTGGAAAGAGGATGGCAAGTTTAGCAGAGATA

AGTTGAAGATAAGTAACAAAGATTGGTTTGACTTTATTCAGAATAAAAGGTATTTAA

AACGTCCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGG

TAGCGGCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAA

CGTAAGGTTATTCCGGGCTAA

[0103] SEQ ID NO: 58

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAACGGCACTAATAATTTCCAGAATTTCATCGGCATTAGCAGCTTACAAAAGACGTT

GAGGAATGCCTTAATACCCACAGAAACTACTCAACAATTTATAGTGAAGAATGGGA

TAATTAAGGAAGACGAGTTGAGAGGTGAAAATAGGCAAATCTTGAAAGACATTATG

GATGACTACTACAGGGGCTTCATTAGTGAAACGTTGTCTTCAATAGATGACATTGAT

TGGACTTCTTTGTTTGAGAAGATGGAAATACAGTTAAAGAACGGCGACAATAAGGA

TACACTTATCAAAGAGCAAACAGAATATAGAAAAGCAATTCACAAAAAGTTTGCTA

ACGATGATAGGTTCAAGAACATGTTTAGCGCTAAACTAATATCAGACATCCTTCCCG

AGTTCGTTATTCATAACAATAACTATAGTGCAAGTGAAAAAGAGGAGAAGACACAG

GTGATTAAGCTGTTCTCCAGATTCGCGACTTCTTTCAAAGATTACTTCAAAAACAGA

GCCAACTGTTTTTCAGCTGACGATATCTCTAGTAGTAGTTGTCACCGTATAGTGAAC

GATAACGCTGAGATCTTCTTTAGCAATGCATTAGTGTATAGAAGGATAGTTAAGTCT

CTAAGCAATGATGATATCAATAAAATTTCCGGAGACATGAAGGACTCCCTAAAGGA AATGTCCTTAGAAGAGATCTACTCATATGAGAAATACGGGGAATTTATTACGCAGG

AAGGGATCTCCTTTTACAATGACATATGCGGGAAGGTCAACTCTTTCATGAACTTAT

ACTGCCAAAAGAACAAGGAGAACAAGAATTTATATAAACTTCAGAAACTTCACAAA

CAAATACTGTGCATAGCCGATACCTCATATGAGGTTCCTTACAAATTTGAATCAGAT

GAAGAGGTATACCAATCCGTTAACGGCTTTCTTGACAATATTAGCTCAAAGCACATC

GTGGAGAGGTTGAGAAAGATTGGTGATAATTATAATGGCTACAATCTAGATAAGAT

ATATATTGTTAGCAAGTTCTACGAGTCTGTGTCCCAAAAAACATATAGGGATTGGGA

GACAATTAATACTGCTCTAGAAATCCATTACAACAACATCCTTCCTGGAAATGGCAA

GAGTAAGGCCGACAAAGTCAAGAAAGCAGTGAAAAATGATCTGCAAAAATCAATTA

CTGAGATAAACGAGCTAGTATCTAATTACAAGCTTTGTAGCGACGATAACATTAAGG

CAGAAACGTACATACACGAGATTAGTCACATCTTAAATAATTTTGAAGCCCAAGAA

CTGAAATATAACCCTGAGATACACCTTGTTGAATCCGAGTTAAAGGCGTCTGAACTA

AAAAACGTGTTAGACGTTATTATGAATGCCTTCCACTGGTGTAGCGTCTTTATGACT

GAGGAGTTGGTTGATAAGGATAATAACTTTTACGCTGAATTGGAAGAAATTTATGAC

GAAATCTATCCTGTTATTTCTCTATATAATTTGGTGAGAAATTACGTAACGCAAAAG

CCCTATAGTACGAAAAAAATAAAACTAAATTTCGGGATCCCTACCCTAGCCGACGGT

TGGTCTAAATCCAAGGAGTACTCAAACAATGCAATAATATTGATGAGGGACAACCT

GTACTACCTAGGCATATTTAATGCCAAAAATAAGCCCGATAAAAAGATTATAGAAG

GGAACACGTCAGAAAATAAAGGAGACTATAAGAAAATGATCTACAACCTTTTGCCC

GGCCCCAATAAAATGATCCCGAAGGTCTTCCTAAGTAGCAAGACTGGCGTAGAGAC

CTACAAACCATCTGCATACATTTTGGAGGGGTACAAGCAAAACAAGCACATAAAGA

GTAGTAAGGATTTTGACATTACATTCTGCCATGACTTAATTGACTACTTTAAAAATT G

CATCGCAATTCACCCTGAATGGAAAAATTTTGGATTTGATTTCTCTGATACTTCAAC A

TATGAGGATATTTCAGGGTTCTACAGGGAGGTCGAACTACAGGGTTACAAAATAGA

CTGGACGTATATTTCTGAGAAAGATATAGATTTGCTTCAGGAAAAGGGTCAGCTATA

TCTGTTCCAGATATATAATAAGGACTTCTCCAAAAAGAGTACCGGAAATGATAATCT

GCACACAATGTACTTAAAAAACTTGTTCTCTGAGGAGAATCTAAAAGACATCGTACT

AAAACTTAACGGGGAGGCCGAAATTTTTTTTAGGAAGTCCAGCATCAAGAACCCGA

TTATTCATAAAAAAGGTAGCATTTTGGTGAACCGTACTTATGAGGCGGAAGAAAAA

GACCAATTCGGTAATATTCAAATCGTTAGAAAGAACATCCCTGAGAACATTTATCAG

GAACTATACAAATACTTTAACGACAAATCAGATAAGGAGCTTTCTGATGAGGCAGC

TAAATTGAAAAATGTAGTGGGACATCACGAAGCAGCCACTAACATAGTGAAGGACT

ACAGATACACATACGATAAGTACTTCCTGCACATGCCTATTACAATTAACTTTAAAG

CAAATAAAACAGGGTTTATTAACGACAGAATCTTACAGTATATTGCCAAAGAAAAG

GATCTGCATGTGATAGGAATAGACAGAGGAGAAAGAAACCTGATATACGTCTCCGT GATTGATACATGTGGGAACATAGTAGAACAGAAGTCCTTTAACATTGTTAATGGGTA

CGATTATCAAATTAAATTAAAACAACAAGAAGGAGCACGTCAAATAGCTAGGAAAG

AATGGAAAGAGATAGGAAAAATTAAGGAAATTAAGGAGGGTTACCTGTCCCTTGTA

ATTCATGAAATATCCAAAATGGTAATTAAATATAACGCGATCATCGCGATGGAAGA

TCTAAGCTACGGGTTCAAAAAAGGCAGGTTTAAGGTGGAGAGGCAAGTTTACCAAA

AGTTCGAGACAATGTTGATTAATAAGTTAAACTACTTAGTTTTCAAAGATATCTCCA

TAACCGAGAATGGCGGGCTTTTAAAAGGGTACCAACTAACATATATCCCGGATAAA

TTGAAGAACGTTGGACACCAGTGTGGCTGCATATTTTATGTACCCGCTGCGTATACT

TCTAAAATTGACCCGACCACCGGGTTTGTAAACATATTCAAGTTTAAGGACCTAACA

GTTGACGCCAAACGTGAGTTCATCAAGAAGTTCGATAGTATAAGGTATGACTCTGAG

AAGAACCTTTTCTGCTTCACGTTTGACTATAATAATTTCATCACCCAAAATACAGTT A

TGTCAAAAAGCTCTTGGTCAGTATATACGTATGGCGTAAGGATTAAGCGTAGGTTCG

TGAACGGTAGATTTTCCAACGAGTCAGATACTATTGATATTACCAAGGATATGGAGA

AGACATTAGAAATGACAGATATAAATTGGAGGGATGGGCACGATCTAAGGCAAGAT

ATCATTGATTACGAAATTGTTCAGCACATATTCGAGATATTCCGTCTTACAGTACAA

ATGCGTAACAGCTTGTCTGAGTTGGAAGATCGTGACTATGACAGGTTGATATCACCG

GTCTTGAACGAGAACAATATATTCTACGACAGCGCTAAGGCGGGAGACGCTCTGCC

TAAAGACGCAGATGCCAATGGGGCGTACTGCATTGCCTTAAAAGGCTTATACGAGA

TTAAACAGATCACAGAGAACTGGAAAGAGGACGGCAAGTTTTCTAGAGATAAATTG

AAAATCTCAAACAAAGACTGGTTCGATTTCATCCAAAACAAAAGATACCTTAAACG

TCCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGC

GGCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTA

AGGTTATTCCGGGCTAA

[0104] SEQ ID NO: 59

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAATGGAACTAACAACTTCCAGAACTTTATCGGCATCTCTTCCCTCCAAAAGACACT

GAGAAATGCACTGATCCCAACCGAAACGACTCAACAATTTATTGTTAAGAACGGCA

TCATAAAAGAAGACGAGCTTCGCGGCGAGAACCGCCAGATACTTAAGGATATTATG

GACGATTATTACCGAGGCTTTATCAGCGAAACTCTTAGCTCTATTGATGATATCGAC

TGGACCTCCCTCTTCGAAAAAATGGAGATACAGCTCAAGAACGGCGATAATAAAGA

CACCTTGATAAAGGAACAGACTGAGTACAGGAAAGCGATCCACAAGAAATTCGCGA

ACGACGACAGGTTTAAAAACATGTTCTCTGCAAAATTGATATCCGACATCTTGCCGG

AATTTGTGATACACAACAATAACTATAGCGCTTCAGAGAAAGAAGAGAAGACCCAA

GTAATCAAGTTGTTCAGCCGCTTCGCAACGTCTTTTAAAGATTACTTTAAGAACCGG GCCAATTGTTTCTCCGCGGATGATATTAGCTCATCAAGTTGCCATCGAATTGTCAAT

GATAATGCGGAGATCTTCTTCAGCAATGCGCTGGTCTACAGACGAATCGTAAAAAGT

CTTTCAAATGACGACATCAATAAGATTAGTGGAGATATGAAGGATTCCCTTAAGGA

AATGAGTCTTGAAGAAATATACTCATACGAAAAGTACGGGGAATTTATTACCCAGG

AGGGGATCTCCTTCTATAACGACATCTGTGGAAAAGTAAACTCATTCATGAACCTGT

ACTGTCAGAAAAACAAAGAAAACAAAAATCTGTATAAACTCCAAAAATTGCACAAG

CAAATATTGTGTATAGCGGACACATCATACGAGGTTCCATATAAGTTCGAAAGTGAT

GAAGAAGTCTACCAATCAGTGAATGGGTTTCTGGACAACATTAGTTCCAAGCACATA

GTTGAACGACTGCGAAAGATTGGTGACAATTACAACGGCTATAATTTGGACAAGAT

TTATATAGTTAGCAAATTTTATGAATCCGTATCACAAAAGACTTATAGAGACTGGGA

AACAATCAACACGGCACTTGAGATCCATTATAACAATATTCTTCCAGGGAACGGCA

AAAGCAAGGCTGATAAGGTAAAAAAGGCCGTTAAGAATGATCTTCAAAAATCCATA

ACGGAGATCAACGAACTTGTAAGTAACTACAAATTGTGCTCTGACGACAATATAAA

GGCTGAAACGTATATTCACGAGATTAGCCATATCCTGAATAACTTTGAGGCCCAAGA

ACTCAAGTATAACCCGGAAATACATTTGGTAGAAAGCGAGCTTAAAGCGAGTGAGC

TGAAAAACGTCCTCGATGTGATCATGAATGCTTTCCACTGGTGTAGTGTCTTTATGA

CTGAGGAGTTGGTTGATAAAGACAATAATTTCTACGCTGAACTGGAAGAAATTTACG

ACGAAATCTATCCAGTGATCTCCCTCTATAACCTCGTTCGAAACTACGTGACGCAGA

AACCTTATTCTACAAAGAAAATTAAGTTGAACTTCGGCATTCCTACACTTGCTGACG

GATGGTCCAAATCCAAAGAGTACTCAAACAACGCAATCATCCTCATGCGGGATAAC

CTTTATTATTTGGGCATTTTCAACGCCAAAAACAAACCTGATAAAAAGATAATTGAA

GGCAATACGAGTGAGAACAAGGGCGACTACAAAAAAATGATATATAACTTGTTGCC

AGGCCCCAACAAGATGATTCCTAAAGTTTTTCTGTCTTCTAAGACTGGAGTTGAAAC

TTACAAACCCTCCGCCTACATTCTTGAAGGGTATAAACAGAATAAGCACATAAAGTC

CTCAAAGGATTTCGACATTACGTTTTGCCATGACCTCATCGACTATTTCAAGAACTG T

ATCGCCATACATCCGGAGTGGAAGAATTTTGGATTTGATTTCTCCGACACATCTACC

TATGAAGACATAAGCGGTTTCTACCGGGAGGTCGAGCTTCAGGGCTATAAGATAGA

TTGGACATACATTAGTGAAAAAGATATCGATCTTCTGCAAGAAAAGGGACAACTTT

ACCTTTTTCAGATTTATAATAAAGACTTTTCAAAAAAGTCCACAGGGAACGATAATC

TGCACACCATGTATCTCAAGAATCTGTTTAGTGAAGAAAACCTTAAAGACATAGTTT

TGAAGCTTAACGGAGAGGCTGAGATTTTTTTTAGAAAGTCCTCAATTAAAAACCCTA

TAATACACAAGAAAGGCTCTATTCTTGTTAACAGGACATATGAAGCCGAGGAGAAA

GATCAGTTTGGCAATATCCAGATTGTTCGCAAGAATATCCCGGAAAATATATATCAG

GAGCTGTATAAATACTTTAACGACAAGAGCGACAAGGAGCTGAGTGACGAGGCCGC

GAAGCTTAAGAATGTAGTAGGTCACCACGAAGCAGCCACCAATATCGTCAAAGACT ATAGGTACACGTACGACAAGTACTTTTTGCACATGCCTATAACTATAAACTTCAAAG

CTAATAAAACTGGGTTTATTAATGACAGGATTCTCCAATACATCGCTAAAGAGAAGG

ATCTGCATGTAATTGGCATAGACAGAGGTGAGAGAAACTTGATATATGTCAGCGTA

ATAGACACATGTGGCAATATCGTGGAACAGAAGTCTTTTAACATCGTCAATGGTTAC

GACTACCAAATTAAGTTGAAACAGCAGGAAGGCGCACGACAGATCGCACGAAAGG

AATGGAAAGAGATAGGCAAAATAAAAGAAATAAAGGAGGGCTATCTCAGTCTCGTT

AT AC ACGAAATTTC AAAAAT GGTT ATTAAGTAC AAT GC AATCAT AGCGATGGAGGA

TCTCAGTTATGGGTTCAAAAAGGGTCGGTTTAAAGTTGAGCGCCAAGTGTACCAAAA

GTTCGAGACAATGCTGATTAACAAGCTGAACTACCTCGTCTTCAAAGATATAAGTAT

TACGGAGAACGGTGGCCTTCTTAAAGGCTATCAACTTACTTACATCCCGGACAAGCT

CAAAAACGTAGGGCACCAATGCGGGTGTATTTTCTATGTGCCTGCGGCATATACGTC

AAAGATTGACCCAACCACAGGATTCGTAAACATATTCAAGTTTAAGGACCTCACCGT

TGATGCGAAAAGGGAGTTCATTAAAAAATTTGATTCTATTCGATATGATAGTGAGAA

AAATCTCTTTTGTTTCACATTTGACTATAATAATTTTATTACTCAGAATACTGTCAT G

AGCAAGTCATCTTGGTCAGTGTACACATACGGGGTGCGGATCAAACGCAGGTTCGTC

AATGGTCGCTTCTCAAACGAATCAGACACCATTGACATCACAAAGGACATGGAAAA

AACCCTTGAGATGACCGACATTAATTGGCGCGATGGTCATGATCTGCGGCAAGACAT

CATAGACTACGAAATCGTCCAACACATCTTTGAGATCTTTCGCTTGACGGTCCAAAT

GCGGAACTCCCTGTCCGAGCTCGAGGATAGAGATTATGATCGGCTGATATCTCCCGT

GCTTAATGAAAATAACATCTTCTACGACTCCGCCAAGGCGGGTGATGCCCTGCCGAA

GGATGCGGATGCTAATGGCGCTTATTGCATTGCTCTTAAGGGGCTCTATGAGATAAA

GCAGATCACGGAAAACTGGAAAGAAGACGGTAAGTTTAGTAGAGACAAGCTGAAG

ATCTCAAATAAAGACTGGTTTGATTTCATACAGAACAAGCGGTACCTGAAACGTCCG

GCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCG

CAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGT

TATTCCGGGCTAA

[0105] SEQ ID NO: 60

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

CAATGGCACTAACAATTTTCAGAATTTCATCGGCATTTCAAGTCTGCAAAAAACTCT

GAGGAATGCTTTGATCCCTACTGAAACCACTCAGCAATTTATAGTCAAGAACGGTAT

AATTAAAGAAGATGAACTCAGGGGTGAAAATAGACAAATACTCAAGGACATTATGG

ATGACTATTATAGAGGCTTCATCTCAGAGACTCTCTCATCAATAGATGATATCGATT

GGACTAGCCTTTTCGAGAAAATGGAGATTCAGTTGAAAAATGGTGATAACAAAGAT

ACGTTGATAAAGGAACAGACCGAGTACAGGAAAGCCATTCATAAGAAATTTGCTAA TGACGATAGATTTAAGAATATGTTTAGTGCAAAACTGATTAGTGACATTCTGCCGGA

GTTCGTTATCCATAATAATAACTACTCTGCATCCGAAAAGGAGGAAAAGACGCAAG

TTATTAAACTGTTCAGCCGCTTCGCCACAAGCTTCAAGGACTACTTCAAAAATAGAG

CCAACTGCTTTTCTGCCGACGATATATCATCATCTTCATGCCATCGGATCGTTAACG A

TAACGCCGAGATATTCTTCAGCAACGCCCTTGTATATCGAAGAATAGTCAAAAGTCT

GAGTAATGATGATATTAATAAAATTAGCGGTGATATGAAAGACTCCCTGAAGGAAA

TGTCACTGGAGGAAATTTATAGTTACGAAAAGTACGGCGAATTCATTACTCAAGAA

GGCATATCCTTCTATAACGACATTTGCGGAAAGGTCAACTCATTCATGAACCTTTAT

TGCCAGAAGAATAAGGAGAATAAAAATCTTTACAAATTGCAAAAACTTCACAAACA

AATTCTTTGCATCGCGGATACGTCCTACGAAGTTCCTTACAAATTTGAATCCGATGA

GGAAGTGTATCAGAGTGTCAATGGATTTTTGGATAATATCTCTTCAAAACATATTGT

GGAGAGATTGCGCAAAATAGGTGATAACTACAATGGCTACAACCTGGACAAGATTT

ATATTGTTAGCAAGTTCTATGAAAGTGTCAGTCAAAAGACCTACAGAGATTGGGAG

ACAATCAACACGGCGCTCGAAATACACTACAATAACATCCTCCCCGGCAATGGGAA

GAGTAAAGCCGATAAGGTTAAAAAAGCTGTTAAGAACGACCTCCAGAAATCCATCA

CGGAAATAAACGAGCTGGTTTCCAACTATAAGCTGTGTAGCGATGATAATATTAAG

GCTGAGACATATATACATGAGATCAGCCACATTCTCAACAATTTCGAGGCACAGGA

ACTCAAATACAATCCCGAGATTCACTTGGTGGAAAGTGAGTTGAAGGCGTCAGAGC

TTAAGAATGTACTTGACGTAATAATGAATGCTTTTCATTGGTGCTCCGTGTTCATGA C

TGAGGAACTCGTGGATAAGGATAATAACTTTTATGCGGAGTTGGAAGAGATATACG

ATGAAATATACCCGGTTATCTCACTGTATAATCTGGTCAGAAATTACGTGACCCAAA

AGCCTTATAGTACAAAAAAAATAAAGTTGAACTTCGGTATTCCGACATTGGCAGATG

GTTGGTCCAAAAGCAAAGAATACTCTAATAACGCCATTATATTGATGCGAGACAATT

TGTATTACCTTGGGATCTTTAACGCGAAAAACAAACCGGATAAGAAGATCATCGAA

GGTAATACATCTGAGAATAAGGGGGATTACAAGAAGATGATTTATAATCTGTTGCC

GGGGCCAAACAAGATGATTCCGAAGGTCTTTCTGTCATCTAAGACAGGAGTAGAGA

CCTACAAACCTTCTGCGTACATTTTGGAAGGCTACAAACAGAACAAGCATATAAAAT

CTAGCAAGGACTTTGATATCACGTTTTGTCATGATCTGATAGATTATTTCAAAAACT

GCATCGCTATACATCCTGAGTGGAAGAATTTCGGCTTTGACTTTTCTGACACCAGCA

CATACGAAGACATCTCAGGTTTCTACCGGGAAGTCGAGCTCCAGGGGTACAAGATT

GACTGGACATATATAAGTGAAAAAGACATCGACCTCCTCCAAGAGAAGGGCCAACT

TTACCTGTTCCAGATCTATAACAAAGACTTTTCTAAAAAGTCCACGGGTAACGACAA

CTTGCACACTATGTATCTGAAAAACTTGTTCTCTGAAGAGAACCTCAAGGACATCGT

CCTGAAGCTTAACGGGGAGGCGGAGATCTTCTTTAGAAAGTCCTCTATCAAAAATCC

CATTATCCATAAAAAGGGCTCTATACTCGTTAATAGGACATATGAAGCGGAGGAAA AAGATCAATTTGGGAACATCCAGATCGTCCGGAAAAATATACCTGAGAATATCTATC

AAGAGCTGTACAAGTATTTTAATGATAAGTCAGACAAAGAGCTCAGTGATGAGGCG

GCAAAGCTCAAGAACGTGGTGGGGCATCATGAAGCTGCGACGAACATTGTCAAAGA

TTATAGATACACTTACGATAAATACTTCCTCCACATGCCGATAACGATTAACTTCAA

AGCCAATAAGACGGGGTTTATAAATGATCGGATCCTTCAGTACATTGCGAAAGAGA

AAGACCTCCATGTGATCGGAATTGACCGAGGAGAAAGGAATCTGATTTACGTGTCC

GTGATTGATACTTGCGGGAATATAGTCGAGCAAAAGAGTTTCAACATAGTCAACGG

GTATGACTATCAGATAAAGCTCAAACAGCAGGAAGGTGCGAGGCAAATTGCGCGCA

AAGAGTGGAAGGAGATAGGCAAGATTAAAGAAATCAAGGAAGGTTATCTCAGCTTG

GTGATCCATGAAATATCTAAGATGGTTATAAAGTACAATGCCATAATAGCCATGGA

GGATCTTTCCTACGGGTTTAAGAAGGGCCGATTTAAAGTGGAGCGACAAGTTTACCA

GAAGTTCGAAACCATGTTGATTAACAAACTTAACTATTTGGTGTTCAAGGATATAAG

TATAACCGAAAACGGCGGTTTGCTTAAGGGTTATCAGCTCACGTATATTCCTGATAA

ACTTAAAAACGTTGGACACCAGTGTGGATGTATCTTCTACGTGCCAGCCGCTTACAC

TAGTAAGATAGATCCTACCACGGGGTTTGTGAATATTTTTAAGTTTAAAGACTTGAC

AGTCGACGCCAAAAGGGAATTTATAAAAAAGTTTGATTCTATCCGCTACGATAGTGA

AAAAAATCTCTTTTGCTTTACTTTCGACTATAACAACTTCATTACGCAGAACACTGT C

ATGAGTAAGTCCAGCTGGAGCGTCTACACATATGGCGTCCGAATTAAACGACGATTT

GTAAACGGGCGGTTTTCAAACGAATCTGACACGATAGACATTACCAAGGATATGGA

GAAGACACTTGAGATGACCGACATAAACTGGCGGGACGGTCACGATCTTCGGCAGG

ACATAATTGATTACGAAATCGTCCAGCATATATTCGAAATATTTCGACTTACAGTGC

AAATGCGGAACAGTCTCTCTGAACTGGAAGATCGCGATTATGACCGGTTGATTTCTC

CGGTCCTCAATGAAAATAACATATTTTATGATAGTGCTAAGGCAGGTGATGCGTTGC

CAAAGGATGCAGACGCTAATGGTGCCTATTGTATCGCGCTCAAGGGATTGTACGAG

ATAAAGCAAATTACGGAGAACTGGAAGGAGGATGGTAAGTTTAGCCGAGACAAGTT

GAAGATTAGCAATAAAGACTGGTTTGATTTTATCCAAAACAAGAGGTACCTGAAAC

GTCCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAG

CGGCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGT

AAGGTTATTCCGGGCTAA

[0106] SEQ ID NO: 61

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAACGGAACTAATAACTTTCAAAATTTCATAGGTATTTCAAGCTTGCAGAAGACCCT

GAGGAATGCCCTGATTCCAACCGAGACAACGCAGCAGTTCATAGTCAAAAATGGCA

TTATTAAGGAAGATGAGCTGCGGGGGGAAAACCGACAGATACTCAAGGATATTATG GACGACTATTACCGGGGATTTATCTCAGAAACGCTGAGCAGTATTGATGACATCGAT

TGGACCAGTCTTTTCGAGAAAATGGAAATTCAACTTAAGAATGGTGACAATAAAGA

CACTCTCATAAAGGAGCAAACTGAATACCGAAAAGCCATACACAAAAAGTTTGCCA

ACGATGACCGCTTTAAAAACATGTTTTCAGCTAAGCTCATTAGCGACATTCTCCCCG

AGTTTGTGATTCATAACAATAACTATAGCGCATCCGAGAAGGAGGAAAAAACCCAA

GTTATCAAATTGTTCAGTAGATTCGCTACGAGCTTTAAAGATTACTTTAAAAACCGG

GCTAACTGCTTCAGTGCAGACGATATCAGCTCCTCATCCTGTCATCGCATCGTCAAT

GATAATGCTGAGATCTTCTTTTCTAATGCACTGGTTTACCGCAGGATAGTTAAGTCT C

TTAGTAACGACGACATCAACAAGATATCAGGAGATATGAAGGATTCCCTTAAAGAA

ATGAGTCTCGAGGAGATATATTCTTATGAAAAATACGGCGAATTTATTACCCAAGAG

GGCATTAGTTTCTATAATGACATATGCGGAAAAGTTAATAGTTTTATGAATCTCTAT T

GTCAGAAGAATAAGGAGAATAAGAACCTCTACAAATTGCAGAAGTTGCACAAGCAA

ATTCTGTGTATCGCGGACACCTCTTACGAGGTCCCATATAAGTTCGAGAGTGATGAA

GAAGTATACCAGAGCGTTAATGGGTTCCTGGACAACATCTCAAGTAAACACATAGT

CGAAAGGCTCCGAAAGATCGGTGATAACTATAACGGATATAATTTGGATAAAATTT

ATATAGTTAGCAAATTTTACGAGAGCGTCAGTCAGAAGACCTACCGGGACTGGGAG

ACCATAAACACAGCGCTGGAAATACATTATAACAACATACTGCCTGGGAACGGTAA

GT CAAAGGC AGACA AGGTT AA AAAGGCTGT GAAGAATGACCTGC AAAAATC AATT A

CAGAAATAAATGAGTTGGTAAGTAATTACAAACTTTGCAGCGATGATAATATAAAG

GCAGAGACGTACATACATGAAATATCTCATATCCTCAACAATTTCGAAGCCCAAGA

ACTGAAGTACAACCCGGAAATTCATCTTGTAGAGTCTGAGTTGAAGGCCTCCGAATT

GAAAAACGTTCTTGACGTAATTATGAATGCCTTCCACTGGTGCTCAGTATTCATGAC

GGAAGAGCTCGTGGATAAAGACAACAATTTTTACGCTGAACTGGAAGAAATATATG

ACGAGATTTACCCCGTAATTTCACTCTACAACTTGGTACGAAATTACGTTACCCAAA

AGCCATACTCAACAAAAAAAATTAAACTGAACTTCGGGATACCCACCCTCGCAGAT

GGATGGTCAAAGTCCAAAGAGTACAGTAACAATGCAATTATCCTGATGCGAGACAA

CCTTTATTACCTCGGGATTTTCAACGCTAAAAATAAACCTGATAAAAAAATAATTGA

GGGTAATACCTCTGAAAACAAGGGGGATTATAAAAAGATGATATACAATCTGCTGC

CTGGCCCGAACAAAATGATTCCTAAAGTCTTCTTGTCTTCCAAGACTGGAGTCGAAA

CCTACAAGCCAAGTGCTTATATACTCGAAGGGTACAAACAAAATAAGCACATAAAA

TCCAGCAAGGATTTTGATATTACATTCTGCCACGATTTGATTGATTATTTTAAGAAC T

GTATAGCCATCCACCCAGAATGGAAGAATTTTGGTTTTGATTTTAGCGATACCTCAA

CATATGAGGATATCTCTGGCTTTTACCGCGAGGTAGAACTGCAAGGTTATAAGATCG

ATTGGACTTATATTTCTGAAAAGGACATAGATCTCCTGCAAGAGAAAGGGCAACTTT

ATTTGTTTCAAATATACAACAAAGATTTTAGTAAGAAGAGTACTGGCAATGATAACC TTCACACTATGTATCTGAAGAACCTTTTTTCTGAGGAGAACTTGAAGGACATAGTCC

TTAAACTCAATGGGGAAGCTGAAATATTCTTTCGCAAAAGCTCCATTAAAAACCCGA

TCATTCATAAAAAGGGTTCCATCTTGGTAAACCGCACATACGAGGCGGAAGAAAAA

GATCAGTTCGGAAATATCCAGATCGTAAGGAAGAATATCCCCGAAAATATATACCA

AGAGCTTTACAAATATTTTAACGATAAGTCAGACAAGGAACTGTCAGACGAAGCAG

CCAAGTTGAAGAATGTCGTAGGGCACCACGAAGCAGCTACAAACATAGTTAAAGAT

TATCGGTACACCTACGATAAATATTTCCTGCATATGCCAATAACCATAAACTTCAAA

GCCAACAAAACAGGGTTCATCAATGACCGAATACTTCAGTATATAGCCAAGGAAAA

AGACCTGCATGTTATAGGAATAGATAGAGGTGAGCGCAACTTGATATATGTCAGCG

TGATAGACACCTGCGGAAATATCGTCGAGCAAAAAAGTTTCAACATTGTTAATGGCT

ACGATTACCAAATTAAATTGAAGCAGCAAGAGGGGGCTCGGCAAATCGCGCGAAAG

GAATGGAAAGAAATCGGGAAGATTAAAGAAATTAAAGAGGGCTACCTGTCTCTTGT

AATTCACGAAATATCTAAGATGGTCATCAAGTATAATGCCATTATTGCGATGGAAGA

TCTGTCCTACGGATTTAAGAAAGGCAGGTTTAAAGTCGAAAGGCAGGTGTACCAGA

AATTCGAGACCATGCTGATTAATAAGCTCAACTATCTCGTATTTAAGGATATTTCTA T

AACTGAAAATGGAGGGCTTCTCAAAGGATATCAACTCACATACATACCTGATAAGC

TGAAGAACGTAGGCCACCAGTGTGGATGCATATTCTATGTACCAGCTGCATACACAA

GCAAGATCGATCCAACTACTGGGTTTGTCAATATCTTCAAATTTAAGGACTTGACGG

TCGATGCCAAACGGGAGTTCATCAAAAAGTTTGATAGTATTCGATATGATAGTGAGA

AGAACTTGTTTTGCTTCACATTTGACTACAACAATTTCATAACGCAAAATACGGTTA

TGTCTAAATCCTCATGGAGCGTCTACACTTACGGAGTGAGGATAAAGCGGCGCTTCG

TAAATGGCAGGTTTAGCAATGAATCCGACACGATTGACATAACCAAGGATATGGAG

AAAACCCTCGAGATGACCGATATAAATTGGCGGGATGGACACGATCTGCGACAAGA

CATAATCGATTATGAAATCGTGCAGCACATATTTGAGATATTCAGGCTTACGGTCCA

AATGAGAAATTCCCTTTCCGAACTTGAAGACCGCGATTACGACCGACTGATAAGCCC

CGTTCTGAACGAAAATAACATCTTCTACGACAGCGCTAAAGCGGGAGACGCGCTGC

CGAAAGATGCGGACGCAAATGGAGCCTATTGTATCGCCTTGAAAGGGTTGTACGAG

ATCAAACAGATAACCGAGAATTGGAAGGAGGATGGGAAGTTTAGTCGAGACAAACT

TAAAATAAGCAACAAGGACTGGTTCGACTTTATTCAAAACAAACGATATCTCAAAC

GTCCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAG

CGGCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGT

AAGGTTATTCCGGGCTAA

[0107] SEQ ID NO: 62

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA TAATGGTACTAACAATTTTCAAAACTTTATCGGCATCTCTTCACTTCAGAAAACTCTT

CGGAACGCCCTTATACCGACGGAGACAACGCAGCAGTTTATAGTTAAAAACGGGAT

CATTAAAGAAGATGAACTCAGAGGGGAAAACAGGCAAATATTGAAGGACATTATGG

ACGATTACTACCGGGGGTTTATTTCAGAGACCCTTTCATCTATTGATGACATAGATT

GGACCTCCCTTTTCGAGAAAATGGAGATACAATTGAAAAACGGCGACAATAAAGAT

ACACTTATCAAGGAACAAACTGAGTATCGCAAGGCGATTCACAAGAAGTTTGCGAA

TGACGATCGCTTTAAGAATATGTTTTCTGCGAAGCTCATAAGTGACATTCTGCCTGA

ATTTGTCATTCATAACAACAATTATTCTGCTAGCGAAAAAGAGGAAAAAACTCAAGT

CATTAAGCTTTTTAGCAGGTTCGCTACTAGTTTTAAAGACTATTTTAAGAACCGGGC

GAATTGCTTTAGCGCTGACGACATATCATCCTCATCCTGTCATCGCATAGTCAATGA

TAATGCAGAAATATTCTTTTCTAATGCGCTCGTGTATCGGAGAATAGTGAAAAGCCT

CTCTAACGATGACATTAACAAAATAAGCGGCGATATGAAGGATAGTCTGAAGGAAA

TGTCCCTCGAAGAAATATACTCATACGAGAAGTACGGAGAATTTATCACCCAGGAA

GGAATTAGTTTTTACAACGACATCTGTGGTAAGGTTAACTCTTTTATGAATCTGTAT T

GTCAAAAGAATAAAGAAAATAAAAATCTTTATAAGCTCCAAAAGCTTCACAAACAA

ATCTTGTGCATTGCGGATACGTCATACGAAGTACCTTACAAATTTGAAAGCGACGAA

GAGGTGTATCAGTCAGTGAATGGGTTCCTTGACAATATTTCTAGCAAACATATTGTG

GAGCGACTTCGAAAGATCGGTGATAATTACAATGGCTATAATTTGGATAAAATTTAC

ATAGTTAGTAAGTTTTATGAATCCGTCTCACAAAAGACGTACCGAGATTGGGAGACC

ATCAACACTGCTCTGGAGATTCATTACAATAATATATTGCCTGGGAATGGGAAGTCA

AAGGCCGACAAGGTTAAAAAAGCCGTAAAAAACGATCTTCAAAAGTCCATTACCGA

GATAAATGAACTTGTATCCAACTATAAGTTGTGCTCTGACGATAATATTAAAGCAGA

AACGTATATCCACGAAATAAGTCACATCCTGAACAACTTCGAAGCTCAAGAGCTCA

AGTATAATCCTGAAATTCATCTCGTCGAAAGCGAGCTGAAAGCATCCGAGTTGAAG

AATGTGCTTGATGTGATCATGAACGCATTCCATTGGTGCAGTGTGTTCATGACCGAA

GAACTTGTAGACAAAGACAACAACTTCTACGCTGAATTGGAAGAGATTTACGATGA

AATTTACCCCGTGATATCCCTCTATAATCTGGTAAGAAATTACGTCACGCAAAAACC

ATACAGTACCAAGAAAATAAAGCTCAACTTTGGTATTCCGACGTTGGCAGATGGGT

GGAGTAAGAGCAAGGAGTATTCTAACAATGCAATCATCCTCATGCGCGACAATTTGT

ATTATCTGGGGATCTTCAACGCGAAAAATAAGCCCGACAAAAAGATAATAGAAGGC

AATACGTCCGAGAACAAAGGGGACTATAAGAAAATGATTTATAACCTTCTTCCAGG

ACCCAACAAGATGATCCCAAAGGTTTTCTTGAGTTCAAAAACCGGCGTAGAAACTTA

TAAACCGTCCGCCTACATTCTGGAAGGGTACAAGCAAAACAAGCACATTAAGTCAT

CTAAGGATTTCGACATTACTTTTTGTCATGATTTGATAGACTACTTCAAAAATTGTA T

AGCGATACATCCGGAATGGAAAAATTTTGGGTTCGATTTTTCCGACACAAGTACTTA TGAAGACATCTCAGGGTTTTATAGGGAAGTTGAACTGCAAGGTTACAAAATAGACT

GGACTTATATTAGTGAGAAGGACATTGATTTGCTCCAGGAAAAGGGTCAATTGTATC

TGTTCCAGATATATAACAAGGATTTCTCTAAAAAATCTACAGGTAACGACAATCTCC

ACACGATGTACCTCAAGAATCTCTTCAGCGAAGAGAATTTGAAGGATATCGTACTTA

AGCTCAATGGAGAAGCGGAAATATTCTTCAGAAAGTCCAGCATTAAGAATCCTATA

ATTCACAAGAAAGGGTCAATTCTCGTAAACCGGACTTATGAGGCCGAAGAAAAAGA

TCAGTTTGGTAACATTCAGATTGTACGGAAAAACATTCCCGAGAACATCTATCAAGA

ACTGTATAAATACTTTAATGATAAATCCGACAAGGAACTTTCTGACGAGGCTGCAAA

ATTGAAGAACGTAGTGGGACACCATGAGGCCGCAACCAATATAGTAAAGGATTACA

GATACACTTATGATAAGTATTTCCTCCATATGCCGATCACGATTAATTTCAAGGCGA

ATAAAACCGGCTTCATTAACGATCGCATTTTGCAATATATTGCGAAGGAAAAGGATT

TGCACGTGATAGGTATAGACCGGGGTGAACGAAACTTGATTTACGTCTCTGTGATCG

ACACATGCGGAAATATAGTTGAACAGAAGTCCTTTAATATTGTGAATGGTTACGACT

ACCAGATAAAATTGAAGCAACAGGAGGGCGCAAGACAGATAGCTCGCAAAGAGTG

GAAGGAAATCGGCAAGATCAAAGAAATAAAGGAGGGTTATCTTTCCCTGGTAATTC

ATGAAATTAGCAAGATGGTTATTAAGTATAATGCTATAATAGCTATGGAGGACCTTT

CCTATGGGTTCAAGAAAGGTCGCTTCAAAGTGGAGCGACAAGTGTATCAAAAGTTC

GAGACTATGTTGATAAATAAATTGAATTATTTGGTTTTTAAAGACATTTCAATAACT

GAGAACGGGGGTCTCTTGAAGGGGTACCAATTGACTTATATTCCGGACAAGTTGAA

GAATGTCGGACACCAGTGTGGTTGCATTTTCTACGTGCCTGCCGCTTACACCTCAAA

AATCGATCCGACCACTGGTTTTGTAAATATATTTAAATTCAAAGATCTCACCGTTGA

TGCCAAACGGGAGTTTATCAAAAAATTCGATTCCATTCGCTACGACTCTGAGAAAAA

CCTTTTTTGTTTCACGTTCGATTATAACAACTTTATAACCCAAAATACTGTAATGTC C

AAGTCAAGTTGGTCTGTCTATACTTACGGAGTAAGGATCAAGCGCCGCTTCGTTAAT

GGGAGATTCTCAAACGAGTCTGATACCATAGACATAACTAAAGACATGGAAAAAAC

CCTGGAAATGACGGACATCAATTGGCGAGACGGGCATGATCTTCGACAGGACATAA

TAGATTACGAAATTGTTCAACACATTTTCGAGATATTTCGACTTACGGTTCAGATGA

GGAATTCCCTTTCCGAATTGGAAGACCGGGATTATGATCGACTTATATCTCCCGTGC

TCAATGAAAACAATATTTTTTATGATTCAGCGAAAGCTGGGGACGCGCTGCCAAAA

GATGCCGATGCCAATGGAGCATACTGTATCGCCCTGAAGGGTTTGTATGAGATTAAG

CAAATTACTGAAAACTGGAAGGAAGATGGCAAGTTTTCTAGAGATAAGCTTAAGAT

TAGCAATAAGGACTGGTTTGACTTCATTCAAAATAAAAGGTATCTTAAACGTCCGGC

AGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCA

GGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTA

TTCCGGGCTAA [0108] SEQ ID NO: 63

ATGGGCCATCATCATCATCATCACAGCAGCGGCGTCGATCTGGGTACCGAGAATTTG

TATTTCCAGAGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAA

TAATGGAACAAATAATTTTCAAAATTTTATTGGTATCAGTTCATTGCAAAAGACTTT

GAGAAATGCTTTGATCCCGACTGAGACCACACAGCAGTTCATCGTCAAAAATGGCA

TAATCAAGGAAGACGAACTTAGGGGTGAGAATAGACAAATATTGAAGGACATCATG

GATGACTATTATAGGGGGTTCATTTCCGAAACGCTCAGTAGTATTGATGACATTGAC

TGGACTAGTCTTTTCGAGAAAATGGAAATTCAGCTTAAGAACGGGGACAATAAAGA

CACGCTGATCAAGGAGCAAACGGAATATAGGAAGGCGATCCATAAAAAATTCGCGA

ATGATGATCGGTTTAAAAACATGTTTAGTGCCAAGTTGATCAGCGACATACTGCCCG

AATTCGTGATCCACAACAATAATTACAGCGCCTCCGAAAAGGAGGAAAAAACTCAG

GTCATTAAATTGTTTAGCCGATTCGCAACGAGTTTCAAAGATTATTTTAAGAACCGG

GCCAACTGTTTTTCAGCGGATGATATTAGCTCCAGCAGCTGCCATCGCATAGTAAAT

GATAACGCTGAAATCTTTTTTAGCAACGCACTTGTCTACCGGAGGATTGTAAAATCA

CTGTCAAATGATGACATTAACAAAATATCTGGAGATATGAAGGACTCACTCAAAGA

AATGAGCCTGGAAGAAATATATTCATACGAAAAATACGGGGAGTTTATTACCCAGG

AAGGTATCAGTTTTTATAATGATATATGTGGAAAAGTTAATTCATTTATGAATCTTT A

CTGTCAAAAAAATAAGGAGAACAAGAATTTGTACAAGCTCCAAAAACTTCATAAAC

AGATTCTGTGCATCGCAGACACAAGTTATGAGGTACCGTACAAATTTGAGAGCGAC

GAAGAAGTTTATCAGAGTGTGAATGGTTTCCTGGACAATATCTCTTCTAAACACATT

GTTGAGAGGCTTAGGAAGATCGGTGATAATTATAACGGCTATAATCTGGACAAAAT

TTATATTGTATCAAAGTTTTATGAATCAGTCTCTCAAAAGACGTATCGGGATTGGGA

AACAATTAACACGGCTCTGGAGATCCACTACAATAACATTCTGCCCGGCAACGGGA

AGAGCAAAGCTGATAAGGTCAAGAAGGCAGTCAAGAACGACCTTCAGAAGAGCAT

AACAGAAATTAACGAATTGGTCAGTAACTACAAACTGTGTAGTGATGACAACATAA

AAGCCGAAACATACATCCATGAAATAAGCCATATCCTGAATAACTTCGAAGCCCAA

GAACTTAAATACAATCCCGAGATTCATCTTGTCGAATCAGAACTCAAGGCGTCCGAG

CTCAAAAATGTCCTTGACGTGATAATGAATGCCTTCCACTGGTGCAGCGTATTCATG

ACGGAGGAGTTGGTAGATAAAGACAACAACTTTTATGCCGAATTGGAAGAGATTTA

TGATGAGATTTACCCCGTTATTTCTCTGTACAACTTGGTTCGAAACTACGTAACACA

AAAACCATACTCAACCAAAAAGATCAAACTCAATTTTGGCATACCTACATTGGCTGA

TGGTTGGTCCAAGTCAAAGGAATATAGCAATAATGCAATAATTCTCATGCGAGATA

ACTTGTATTATTTGGGGATCTTTAACGCTAAGAACAAACCAGATAAAAAGATAATCG

AGGGGAACACAAGTGAGAACAAGGGTGATTACAAAAAAATGATTTACAATCTGCTT

CCTGGGCCTAACAAAATGATTCCGAAGGTGTTTCTTAGCTCTAAAACTGGAGTGGAG ACGTATAAGCCTTCCGCGTACATTCTCGAAGGCTACAAGCAAAATAAGCATATCAA

GTCCAGTAAGGACTTCGACATCACTTTTTGCCACGATCTCATCGATTACTTTAAGAA

CTGTATCGCAATACACCCCGAGTGGAAAAACTTTGGTTTTGATTTTTCAGACACTAG

TACCTACGAGGACATTTCCGGCTTCTATCGAGAAGTCGAACTCCAGGGCTACAAAAT

CGATTGGACGTACATTTCTGAGAAGGACATCGACTTGCTCCAAGAGAAAGGTCAAC

TTTACCTCTTCCAAATTTACAATAAAGACTTTTCAAAGAAGAGCACCGGTAATGACA

ACTTGCATACCATGTATCTGAAGAACCTGTTTTCTGAGGAGAACCTCAAGGATATTG

TATTGAAGTTGAATGGCGAAGCAGAAATATTTTTCCGAAAGTCATCTATCAAGAACC

CCATTATACACAAAAAAGGCTCTATCCTGGTGAACCGGACTTACGAGGCAGAGGAG

AAGGATCAATTCGGAAACATACAGATAGTCCGCAAAAACATCCCTGAGAATATCTA

TCAGGAACTCTATAAGTACTTCAATGATAAATCAGACAAGGAGCTTAGCGACGAAG

CAGCTAAACTTAAAAACGTGGTTGGCCATCACGAGGCCGCTACCAACATAGTCAAA

GACTACCGCTATACTTATGACAAGTACTTTTTGCACATGCCCATAACAATTAATTTC A

AAGCTAACAAAACAGGGTTTATAAATGACAGAATCCTCCAATACATCGCCAAAGAG

AAGGACCTCCATGTAATCGGGATTGATAGAGGCGAACGGAACTTGATTTACGTTAGT

GTCATTGATACCTGTGGTAACATTGTCGAACAAAAGTCATTCAACATAGTCAATGGA

TATGATTATCAGATAAAACTCAAGCAACAAGAAGGCGCGAGGCAGATTGCCAGGAA

GGAATGGAAAGAAATCGGGAAGATCAAGGAGATCAAGGAGGGTTACCTGTCCTTGG

TGATACACGAGATTTCAAAAATGGTTATAAAATACAATGCCATTATCGCGATGGAG

GATTTGTCTTATGGATTTAAGAAGGGGAGGTTCAAAGTCGAACGACAAGTCTATCAG

AAGTTTGAAACAATGCTCATTAACAAGCTCAATTACCTTGTTTTCAAGGATATAAGC

ATCACTGAAAACGGCGGACTCCTTAAGGGATATCAGCTGACTTATATCCCCGACAAG

CTCAAGAACGTAGGGCACCAATGCGGATGCATCTTTTACGTGCCTGCAGCATATACT

TCAAAAATTGATCCGACTACTGGCTTTGTTAACATTTTCAAGTTCAAGGATCTGACG

GTAGACGCTAAGAGAGAATTCATAAAAAAGTTTGACAGCATCAGGTACGATAGTGA

AAAGAACCTTTTTTGTTTTACCTTTGACTACAATAATTTTATTACGCAAAATACAGT T

ATGAGCAAATCAAGTTGGAGCGTTTACACATATGGCGTTCGGATCAAGCGCAGATTC

GTCAATGGTCGCTTCTCAAATGAGAGCGATACAATCGATATAACGAAGGATATGGA

GAAGACGCTTGAGATGACAGATATCAACTGGCGGGACGGACATGACCTTAGACAAG

ACATAATCGATTACGAAATAGTACAGCATATCTTTGAGATTTTTAGGCTTACAGTTC

AGATGCGGAACTCTCTTTCCGAACTGGAGGACCGGGATTATGATCGGTTGATCTCCC

CAGTACTGAACGAAAATAATATCTTTTACGATAGCGCGAAGGCTGGTGATGCACTCC

CAAAAGACGCTGATGCGAACGGAGCTTATTGCATAGCCCTTAAAGGGCTTTACGAG

ATTAAACAAATAACAGAAAATTGGAAGGAAGATGGCAAATTTTCCCGCGACAAGTT

GAAGATTAGTAACAAAGACTGGTTCGACTTCATTCAGAATAAACGCTACCTCAAAC GTCCGGCAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAG

CGGCGCAGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGT

AAGGTTATTCCGGGCTAA

[0109] SEQ ID NO: 64

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGTA

CCAATAACTTCCAGAACTTCATCGGTATTTCTAGCCTGCAAAAGACCCTGCGTAACG

CGCTGATTCCGACCGAGACTACCCAGCAATTCATCGTGAAAAACGGTATCATTAAGG

AAGATGAATTGCGCGGTGAGAATCGTCAGATTCTGAAAGATATCATGGATGACTAC

TATCGCGGTTTCATTAGCGAAACCCTGTCGAGCATCGATGATATCGATTGGACGAGC

CTCTTCGAGAAAATGGAAATTCAACTGAAAAATGGTGACAACAAAGATACCCTGAT

TAAAGAACAAACGGAATACCGCAAGGCAATCCATAAAAAGTTTGCGAATGACGACC

GTTTTAAGAATATGTTCTCGGCCAAGCTGATTTCCGACATCCTGCCAGAGTTCGTCA T

TCACAACAACAATTACAGCGCAAGCGAGAAAGAGGAAAAGACTCAGGTCATTAAGC

TGTTTAGCCGCTTTGCGACGTCCTTCAAAGACTACTTCAAGAATCGTGCGAATTGCT T

TAGCGCGGATGACATCTCTAGCTCTAGCTGTCACCGTATTGTTAACGACAATGCAGA

GATTTTCTTCAGCAACGCCCTGGTGTATCGCCGTATTGTCAAGTCTCTGAGCAACGA

CGACATTAACAAGATCAGCGGCGACATGAAAGACAGCCTGAAAGAAATGTCTCTGG

AAGAAATCTACAGCTACGAGAAATATGGTGAGTTTATCACCCAAGAGGGCATTAGC

TTCTACAATGATATCTGTGGTAAGGTTAATAGCTTTATGAATCTGTACTGCCAGAAG

AATAAAGAAAACAAGAACTTGTACAAGCTGCAAAAGCTGCATAAGCAAATTCTGTG

CATCGCCGATACTAGCTATGAAGTTCCGTACAAGTTCGAGTCTGATGAAGAGGTGTA

TCAGTCAGTCAACGGTTTTCTGGATAACATCAGCAGCAAGCACATCGTCGAGCGCCT

GCGCAAGATTGGTGACAACTACAATGGTTATAACCTGGACAAGATCTATATCGTGTC

GAAGTTTTACGAGAGCGTGTCCCAGAAAACGTACCGTGATTGGGAAACGATTAACA

CGGCCTTGGAAATTCACTATAACAATATCCTGCCGGGCAACGGCAAGAGCAAAGCT

GAC AAAGTC AAAAAAGCTGT GAAA AACGAT CTGC AAAAGTCC ATC ACCGAGATCA A

CGAACTGGTTAGCAACTATAAGCTGTGTAGCGACGACAACATTAAAGCTGAAACGT

ATATCCACGAAATCAGCCACATCCTGAATAACTTTGAGGCACAAGAACTGAAATAC

AATCCTGAGATCCATCTGGTAGAGAGCGAGCTGAAGGCAAGCGAGTTGAAAAACGT

TCTCGACGTTATCATGAATGCTTTCCACTGGTGTAGCGTGTTTATGACCGAAGAACT

GGTTGACAAAGATAACAATTTCTATGCAGAGCTGGAAGAAATCTATGATGAAATCT

ACCCGGTCATCAGCCTGTATAACCTGGTTCGTAACTACGTGACGCAGAAGCCGTACA

GCACCAAAAAGATCAAGCTGAACTTCGGTATTCCGACCTTGGCGGACGGTTGGAGC

AAATCCAAAGAATACTCCAATAATGCGATTATTCTGATGCGTGATAATCTGTACTAT

CTGGGTATCTTCAATGCGAAGAACAAGCCAGATAAAAAGATTATTGAAGGCAACAC CAGCGAGAATAAAGGCGACTACAAGAAAATGATCTACAACTTATTGCCGGGTCCGA

ACAAGATGATCCCGAAAGTTTTTCTGAGCAGCAAGACCGGCGTTGAAACCTATAAG

CCGAGCGCGTACATTTTAGAGGGCTATAAACAAAACAAGCACATCAAGAGCAGCAA

AGATTTTGATATTACGTTCTGCCACGACCTGATCGACTATTTCAAGAATTGTATTGC G

ATTCACCCTGAGTGGAAGAACTTCGGTTTTGACTTTTCCGATACCTCCACCTATGAA

GATATTAGCGGTTTTTACCGTGAAGTCGAGTTGCAGGGTTATAAGATTGATTGGACT

TACATTTCCGAGAAAGACATCGACCTGTTGCAAGAGAAAGGTCAGCTGTACCTGTTT

CAGATCTATAACAAAGATTTCAGCAAAAAGTCGACGGGCAATGATAATCTGCACAC

CATGTATCTGAAAAACCTGTTTAGCGAAGAGAACCTGAAAGACATTGTTCTTAAGCT

GAATGGTGAGGCCGAGATCTTCTTCCGTAAAAGCTCCATTAAGAACCCGATTATCCA

CAAAAAGGGCTCTATTCTGGTTAACCGCACGTACGAAGCGGAAGAGAAAGATCAAT

TTGGTAACATCCAGATCGTGCGTAAGAATATCCCGGAGAACATTTACCAAGAACTGT

ATAAGTATTTCAATGACAAGAGCGATAAAGAATTGAGCGATGAAGCGGCAAAGCTG

AAAAACGTCGTTGGCCACCACGAAGCCGCGACGAATATCGTGAAAGATTATCGTTA

CACCTACGACAAGTACTTTCTGCACATGCCGATCACCATCAATTTCAAAGCGAATAA

AACGGGTTTTATCAATGACCGTATCCTGCAGTACATTGCGAAAGAAAAAGATTTACA

CGTGATTGGTATTGATCGCGGCGAGCGCAATCTGATTTACGTCAGCGTTATCGACAC

GTGCGGCAATATTGTGGAGCAGAAAAGCTTCAATATCGTCAATGGTTACGACTACCA

GATCAAACTGAAGCAACAAGAGGGCGCCCGCCAGATTGCGCGTAAAGAGTGGAAA

GAAATCGGTAAGATTAAAGAAATCAAGGAAGGCTACCTGTCCCTGGTGATCCATGA

AATCAGCAAAATGGTGATCAAGTACAACGCTATCATTGCGATGGAAGATCTGAGCT

ACGGTTTTAAAAAGGGTCGCTTCAAAGTTGAGCGTCAAGTGTATCAGAAATTTGAGA

CTATGCTGATTAACAAGTTGAACTATCTGGTTTTTAAAGACATCAGCATTACCGAGA

ATGGTGGCCTGCTGAAGGGTTATCAACTGACCTATATTCCTGACAAGTTGAAAAATG

TTGGTCATCAGTGTGGTTGCATTTTCTACGTACCGGCAGCGTACACGAGCAAGATTG

ACCCGACCACGGGTTTCGTTAACATTTTCAAGTTTAAAGATTTGACCGTGGACGCCA

AGCGTGAGTTCATTAAAAAGTTCGACAGCATCAGATACGACTCTGAGAAGAATCTG

TTCTGCTTTACGTTCGACTACAATAACTTCATTACCCAAAATACCGTTATGAGCAAA

AGCTCCTGGAGCGTGTACACGTACGGCGTCCGTATCAAGCGTCGTTTTGTGAATGGT

CGCTTTTCCAACGAATCTGACACCATTGACATTACCAAAGATATGGAAAAGACCCTT

GAGATGACCGACATTAATTGGCGTGATGGCCATGACTTGCGCCAAGACATTATCGAC

TACGAAATTGTTCAGCACATCTTTGAGATTTTTCGTCTGACGGTCCAGATGCGCAAC

TCGCTGAGCGAGTTGGAAGATCGTGACTATGACCGTCTGATTAGCCCGGTGCTGAAT

GAAAACAATATCTTCTATGATAGCGCAAAGGCCGGTGACGCGCTGCCGAAAGATGC

GGATGCTAACGGTGCATACTGCATTGCACTGAAGGGTCTGTACGAAATCAAACAGA TCACCGAGAATTGGAAAGAGGATGGTAAGTTTAGCCGTGATAAGCTGAAGATTAGC

AATAAAGACTGGTTCGACTTTATTCAAAACAAGCGCTATCTGAAACGTCCGGCAGCG

ACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCA

GCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCG

GGCTAA

[0110] SEQ ID NO: 65

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAA

CAAATAATTTTCAGAACTTTATTGGGATCAGTTCGCTTCAGAAAACGCTTCGTAATG

CTCTGATTCCCACAGAAACCACTCAGCAGTTTATCGTAAAGAATGGCATTATCAAGG

AGGATGAATTACGCGGCGAGAACCGCCAAATCTTAAAAGATATCATGGACGACTAC

TACCGCGGTTTCATTAGCGAAACTCTTAGTTCAATTGACGACATTGACTGGACGTCC

TTGTTCGAAAAGATGGAGATTCAATTAAAGAACGGTGATAACAAGGATACGTTGAT

TAAAGAACAGACGGAGTACCGTAAGGCTATCCACAAAAAATTTGCAAACGACGACC

GCTTTAAAAATATGTTTAGCGCAAAATTAATCTCCGACATCCTGCCTGAATTCGTCA

TCCATAACAATAACTATAGCGCCTCGGAAAAAGAAGAAAAAACGCAGGTTATTAAA

CTTTTCTCGCGCTTTGCAACAAGCTTTAAGGATTACTTCAAAAATCGCGCCAATTGT T

TTTCAGCCGACGACATTAGCTCCAGTTCCTGCCACCGTATTGTGAATGACAACGCTG

AGATTTTTTTTTCCAATGCGCTGGTTTATCGTCGTATTGTTAAGAGCCTTAGTAACG A

CGACATTAATAAAATTAGCGGTGATATGAAGGATAGCTTGAAAGAAATGAGTCTGG

AAGAGATCTATAGTTACGAGAAGTACGGCGAATTTATTACCCAGGAGGGCATTTCAT

TTTACAATGATATCTGTGGAAAAGTCAACTCCTTTATGAACTTGTATTGCCAAAAGA

ATAAAGAAAACAAAAACCTGTACAAACTGCAAAAGTTACACAAGCAGATTTTGTGT

ATCGCAGACACGTCATACGAAGTACCGTACAAGTTTGAGTCCGATGAAGAAGTGTA

CCAAAGCGTTAATGGCTTTTTGGATAACATTTCGAGCAAACATATCGTAGAGCGTTT

GCGTAAGATTGGTGATAATTACAACGGTTACAATTTAGACAAAATCTATATCGTCTC

TAAGTTTTACGAAAGTGTTTCTCAGAAAACTTACCGCGATTGGGAGACGATCAACAC

TGCGCTGGAGATTCATTACAATAATATCCTTCCAGGTAACGGTAAAAGCAAAGCTGA

TAAGGTGAAAAAGGCGGTTAAAAATGACCTTCAAAAGTCTATCACAGAAATCAACG

AATTGGTCAGCAATTATAAGCTTTGCAGTGACGATAACATTAAGGCCGAGACTTACA

TCCATGAGATCTCTCACATTCTTAATAATTTTGAAGCGCAAGAGCTGAAATACAATC

CTGAAATCCATCTGGTCGAAAGTGAATTAAAAGCCTCCGAATTAAAAAATGTCTTGG

ACGTGATCATGAATGCGTTCCATTGGTGCTCAGTTTTTATGACGGAAGAGTTGGTGG

ACAAAGACAACAATTTTTACGCCGAGCTTGAGGAAATTTACGACGAAATTTACCCCG

TTATTTCGTTATACAACCTTGTGCGTAATTACGTTACACAAAAGCCCTATTCGACAA

AGAAAATCAAGTTAAATTTCGGGATTCCCACATTAGCTGATGGATGGTCCAAATCCA AAGAATACTCGAATAACGCTATCATCCTTATGCGTGATAATTTGTACTACTTAGGCA

TCTTCAATGCGAAGAACAAACCTGACAAGAAAATTATCGAAGGAAACACTTCGGAG

AACAAAGGTGATTATAAAAAGATGATCTACAACTTGCTTCCCGGGCCAAACAAAAT

GATTCCCAAGGTATTTTTGAGTTCTAAAACCGGTGTCGAAACTTACAAACCAAGTGC

TTATATTTTGGAAGGATACAAACAGAACAAACATATCAAGTCTTCGAAAGACTTCGA

TATTACGTTCTGCCACGATCTGATCGATTACTTCAAGAACTGTATTGCTATTCACCC C

GAGTGGAAGAACTTTGGATTTGATTTCTCCGACACGTCCACTTATGAAGATATCTCT

GGCTTCTATCGCGAGGTTGAATTACAAGGGTATAAGATTGACTGGACTTATATTTCG

GAGAAGGATATCGATCTTTTGCAAGAAAAAGGGCAACTTTATTTATTTCAGATCTAT

AACAAGGACTTTTCAAAAAAGAGCACTGGAAATGACAATCTGCATACCATGTACCT

TAAGAACCTGTTCTCGGAAGAGAACCTGAAGGACATTGTACTTAAACTGAATGGAG

AGGCAGAGATCTTCTTTCGCAAATCAAGCATTAAGAACCCAATTATTCACAAAAAG

GGGAGTATCTTAGTAAATCGCACATATGAGGCTGAGGAAAAAGATCAGTTTGGTAA

CATTCAGATCGTGCGTAAGAACATTCCTGAAAATATCTATCAGGAACTTTATAAGTA

TTTCAACGATAAAAGTGATAAAGAGCTGAGTGACGAAGCGGCTAAACTTAAGAATG

TTGTGGGACACCATGAGGCAGCAACCAATATTGTGAAGGATTATCGCTATACGTACG

ACAAATACTTTTTACACATGCCCATCACTATTAATTTTAAAGCTAATAAGACTGGCT T

CATTAACGATCGCATCCTGCAGTACATTGCTAAGGAAAAGGATCTTCACGTTATCGG

TATCGATCGCGGGGAGCGTAATCTTATCTACGTCTCTGTCATTGACACGTGTGGCAA

TATTGTGGAGCAAAAGTCCTTCAATATTGTTAACGGCTATGACTATCAGATTAAATT

GAAACAGCAGGAAGGTGCGCGTCAGATTGCCCGCAAGGAATGGAAGGAAATTGGC

AAGATCAAAGAAATTAAGGAGGGCTACTTAAGCTTAGTAATTCACGAAATTAGTAA

AATGGTTATCAAATACAACGCCATCATCGCGATGGAGGATCTTTCGTACGGGTTTAA

GAAAGGTCGTTTTAAAGTGGAGCGTCAGGTGTACCAGAAATTTGAAACTATGCTTAT

TAACAAACTTAACTACCTGGTTTTCAAGGATATCAGTATTACTGAAAACGGGGGGCT

GTTAAAAGGGTATCAATTAACTTACATTCCAGACAAATTAAAGAACGTTGGACATCA

GTGTGGCTGCATTTTTTATGTACCAGCTGCATACACTTCAAAGATCGATCCTACGAC T

GGGTTCGTGAACATTTTTAAGTTTAAAGACTTGACGGTAGATGCCAAGCGCGAATTC

ATCAAGAAATTCGACAGCATTCGCTACGACTCTGAGAAAAATCTTTTCTGTTTCACA

TTCGATTATAACAATTTCATTACGCAGAACACAGTAATGTCCAAGTCTTCTTGGAGT

GTTTATACATATGGTGTCCGCATTAAGCGCCGTTTCGTCAACGGCCGCTTCAGTAAT

GAGAGCGATACTATTGACATCACAAAAGACATGGAAAAAACACTGGAAATGACCGA

CATCAATTGGCGTGACGGCCATGACTTACGTCAGGATATCATTGATTATGAGATCGT

TCAACACATCTTCGAAATCTTTCGCTTGACTGTTCAAATGCGCAATTCCTTGTCGGA A

TTGGAGGACCGTGATTATGACCGCTTAATTTCCCCCGTCTTAAATGAAAACAATATT TTTTATGACTCTGCAAAAGCTGGAGATGCTCTGCCGAAAGACGCCGATGCAAATGG

GGCATATTGCATTGCTTTAAAGGGGCTTTACGAGATCAAGCAAATCACCGAAAACTG

GAAAGAGGATGGAAAGTTTTCGCGTGATAAACTGAAGATCTCTAACAAAGACTGGT

TCGACTTTATCCAGAACAAGCGTTATTTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0111] SEQ ID NO: 66

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGCA

CCAATAACTTCCAAAACTTCATCGGGATCTCTAGCCTTCAGAAGACGCTTCGCAATG

CTCTTATCCCAACTGAGACCACTCAACAATTTATTGTGAAGAATGGAATTATTAAAG

AGGACGAACTGCGTGGCGAGAATCGTCAGATCTTAAAGGACATTATGGATGATTAT

TACCGTGGATTCATCTCCGAAACATTATCGTCGATCGATGATATCGATTGGACTTCT C

TGTTCGAGAAAATGGAAATTCAATTGAAAAACGGAGATAATAAAGATACGCTTATC

AAAGAACAGACGGAATATCGTAAAGCGATTCATAAGAAATTCGCAAATGACGATCG

TTTCAAAAATATGTTCAGTGCCAAGCTTATTTCGGACATTTTACCTGAATTTGTAAT T

CATAATAATAACTACTCAGCAAGTGAGAAGGAGGAGAAAACCCAAGTTATTAAACT

GTTCTCTCGTTTCGCAACGTCCTTTAAAGATTACTTTAAAAACCGCGCGAATTGCTT T

AGCGCTGACGACATTTCCAGCTCATCCTGTCATCGCATCGTAAACGACAATGCGGAA

ATCTTCTTCAGCAACGCCCTGGTTTACCGCCGCATCGTCAAAAGCTTATCGAATGAC

GACATCAATAAGATCTCAGGAGATATGAAGGACTCGCTTAAGGAGATGTCTCTGGA

GGAAATTTATAGTTACGAAAAGTATGGAGAGTTCATTACCCAGGAGGGAATCTCGTT

CTACAATGACATTTGCGGGAAGGTGAACTCCTTCATGAACTTATACTGCCAGAAAAA

CAAAGAGAACAAAAATCTGTATAAATTGCAGAAATTACATAAACAGATTCTTTGTAT

TGCTGACACTTCCTACGAAGTACCCTATAAATTCGAGTCAGATGAAGAAGTATACCA

GTCCGTGAACGGATTTCTGGACAATATCTCCTCAAAACACATCGTGGAACGCTTACG

TAAAATTGGCGATAATTATAATGGTTACAATCTTGACAAAATTTATATCGTATCTAA

ATTTTACGAGAGTGTGAGCCAAAAGACCTACCGCGACTGGGAGACCATCAACACAG

CTTTAGAAATTCACTATAATAATATCTTACCCGGCAATGGTAAGAGCAAGGCTGACA

AGGTAAAAAAGGCCGTCAAGAATGATTTGCAGAAATCTATTACAGAAATTAATGAG

TTAGTCTCCAACTATAAGCTTTGTTCCGACGATAACATCAAAGCTGAGACATATATT

CATGAGATTAGTCACATTCTTAACAACTTCGAGGCCCAGGAACTTAAGTACAATCCT

GAAATTCATCTTGTCGAGTCTGAGCTGAAAGCTAGTGAATTGAAAAATGTTTTAGAC

GTTATTATGAACGCATTCCACTGGTGCTCTGTGTTTATGACAGAAGAACTGGTCGAC

AAGGACAATAACTTCTATGCCGAACTTGAGGAAATCTACGATGAAATTTACCCTGTA

ATCTCCTTGTATAATCTTGTACGTAATTACGTCACTCAAAAACCTTACAGCACGAAA AAAATTAAATTGAACTTCGGGATTCCTACACTTGCCGACGGGTGGTCTAAATCCAAG

GAATATAGCAACAATGCCATTATTTTAATGCGCGACAATCTTTACTATTTAGGAATT

TTTAACGCTAAGAACAAGCCCGATAAAAAGATTATTGAAGGAAACACGTCTGAAAA

TAAGGGCGACTACAAAAAGATGATTTATAACCTTTTGCCCGGTCCAAACAAAATGAT

CCCAAAGGTATTCCTGTCATCCAAAACAGGGGTTGAGACATATAAGCCCAGCGCAT

ATATTCTGGAAGGATACAAACAGAATAAACATATCAAAAGCAGCAAAGATTTTGAC

ATTACTTTTTGCCACGATTTAATCGACTACTTCAAAAACTGTATCGCTATCCACCCT G

AATGGAAGAATTTCGGATTTGATTTCTCAGATACAAGTACGTATGAGGATATCAGCG

GTTTCTATCGCGAAGTTGAACTTCAAGGGTATAAAATTGACTGGACCTACATTAGTG

AGAAGGACATCGACCTGTTACAGGAAAAAGGCCAATTGTACTTGTTTCAGATCTACA

ATAAGGATTTCTCAAAAAAATCGACCGGCAATGATAACTTGCACACCATGTACCTGA

AGAACCTTTTTTCGGAGGAAAACCTTAAAGACATTGTCCTGAAGTTGAATGGAGAA

GCGGAGATTTTCTTTCGTAAGTCTTCCATTAAAAATCCAATTATTCATAAGAAGGGC

AGCATCCTTGTGAACCGTACGTACGAGGCGGAAGAGAAGGACCAATTCGGTAACAT

TCAAATCGTCCGCAAGAACATCCCTGAAAATATTTATCAGGAGCTTTACAAGTATTT

CAATGATAAGTCCGACAAGGAATTATCAGATGAGGCTGCGAAGTTGAAAAATGTTG

TTGGTCATCACGAGGCGGCGACGAATATTGTAAAGGATTATCGCTACACTTATGACA

AGTACTTTCTGCACATGCCGATCACCATTAATTTCAAGGCGAACAAAACAGGATTTA

TTAATGACCGCATCTTACAATACATTGCCAAAGAAAAGGACTTACACGTTATTGGCA

TTGATCGTGGAGAACGCAACTTAATCTACGTAAGCGTTATTGACACTTGCGGGAATA

TCGTAGAACAAAAGAGCTTCAACATCGTGAATGGTTACGATTACCAGATCAAGCTTA

AGCAGCAGGAGGGAGCGCGCCAGATCGCGCGCAAGGAATGGAAGGAGATTGGTAA

GATCAAGGAAATCAAGGAAGGTTATCTGTCCTTGGTAATCCACGAAATTTCGAAAAT

GGTTATCAAATACAATGCTATTATTGCAATGGAGGACTTGTCCTACGGCTTTAAAAA

AGGACGCTTTAAGGTGGAGCGCCAGGTTTATCAAAAGTTTGAAACAATGCTGATTA

ACAAGCTGAACTATTTGGTCTTTAAAGATATCTCCATCACCGAAAATGGTGGGCTTT

TGAAAGGCTATCAACTTACATATATCCCTGATAAGCTTAAGAATGTGGGTCATCAGT

GCGGGTGCATTTTTTATGTTCCTGCAGCCTACACGTCCAAAATCGATCCTACAACTG

GATTTGTTAATATCTTCAAATTTAAGGATCTTACCGTCGACGCGAAGCGCGAATTTA

TCAAGAAATTCGATAGTATTCGTTATGATTCCGAAAAAAACCTTTTCTGTTTCACCT T

TGATTATAATAACTTTATCACGCAAAATACTGTCATGAGCAAATCGAGTTGGTCTGT

GTACACTTACGGAGTACGCATCAAGCGTCGTTTTGTTAATGGGCGCTTCAGTAACGA

GTCAGACACGATTGATATCACAAAAGATATGGAGAAAACGCTGGAGATGACAGACA

TCAATTGGCGCGATGGTCATGACTTACGTCAAGACATTATCGATTATGAAATTGTCC

AGCATATCTTTGAGATCTTTCGTTTGACTGTTCAGATGCGCAACAGCCTGTCAGAAT T GGAGGATCGTGACTATGATCGCCTTATTTCTCCCGTCTTAAATGAGAACAATATCTT

CTACGACTCAGCCAAGGCTGGAGATGCACTGCCAAAAGACGCCGACGCAAATGGGG

CCTACTGTATTGCATTGAAGGGGTTGTACGAGATCAAACAGATTACAGAAAATTGG

AAGGAGGACGGTAAGTTCTCTCGTGATAAGCTGAAGATTTCTAACAAAGACTGGTTC

GATTTCATTCAGAACAAACGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCCGG

CCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAAA

CGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0112] SEQ ID NO: 67

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGTA

CCAATAACTTTCAGAATTTCATTGGAATCAGCAGCTTACAGAAAACCCTGCGCAATG

CACTTATCCCCACTGAGACAACCCAGCAGTTCATTGTAAAGAACGGGATTATTAAAG

AAGATGAGCTTCGCGGGGAGAATCGTCAGATCTTAAAGGATATTATGGACGATTAC

TACCGTGGCTTCATTTCGGAGACGCTGTCGTCGATCGACGACATCGACTGGACATCC

TTGTTTGAAAAGATGGAAATCCAACTGAAGAATGGCGATAACAAGGACACGTTAAT

CAAAGAGCAGACGGAATACCGTAAAGCTATCCACAAAAAGTTCGCTAATGACGACC

GCTTTAAGAACATGTTCTCAGCAAAACTTATTAGCGATATTTTACCTGAATTTGTCA T

CCACAATAACAATTACTCCGCGAGTGAAAAAGAGGAGAAAACCCAGGTGATTAAGC

TGTTTTCCCGTTTTGCAACCAGTTTCAAGGACTATTTTAAGAATCGTGCTAATTGTT T

CTCTGCAGACGACATTTCCTCGTCGTCCTGCCATCGCATTGTTAATGATAATGCTGA A

ATCTTTTTTTCAAACGCACTTGTGTATCGTCGCATTGTCAAAAGCTTAAGTAATGAC G

ATATCAATAAGATCTCAGGAGACATGAAGGACTCCCTGAAAGAAATGTCATTGGAA

GAAATTTACTCTTATGAAAAGTATGGAGAATTTATTACGCAGGAGGGTATCAGCTTC

TATAACGACATTTGTGGTAAAGTGAACAGCTTTATGAATCTTTATTGTCAAAAGAAT

AAAGAGAACAAAAATCTGTACAAGCTGCAGAAATTGCATAAACAAATTCTGTGCAT

TGCAGATACTTCGTATGAGGTTCCTTACAAATTCGAGTCGGATGAGGAGGTGTATCA

AAGCGTAAACGGATTTTTGGATAACATTAGTAGTAAGCATATTGTGGAACGCCTTCG

CAAGATTGGTGACAACTATAACGGATACAACTTAGACAAGATCTATATTGTCTCGAA

GTTTTACGAAAGTGTTTCCCAAAAGACTTATCGCGACTGGGAGACAATCAACACTGC

GCTGGAAATTCACTATAACAATATCTTGCCGGGGAACGGAAAAAGTAAGGCAGATA

AGGTGAAGAAAGCAGTCAAAAATGATCTGCAAAAAAGCATTACTGAAATTAACGAA

CTTGTGTCAAATTACAAATTGTGTTCGGATGACAATATTAAAGCGGAAACGTATATC

CACGAGATCTCGCACATTCTTAATAATTTCGAGGCGCAGGAATTAAAGTATAATCCT

GAGATCCATTTGGTGGAATCAGAACTTAAAGCTAGTGAACTGAAAAATGTCCTGGA

CGTTATTATGAATGCATTTCACTGGTGTTCTGTCTTTATGACAGAAGAACTTGTCGA C

AAAGACAACAACTTTTATGCGGAATTAGAAGAGATTTACGACGAAATTTATCCCGTT ATTTCGTTATATAATTTAGTTCGTAATTACGTGACTCAGAAACCCTACAGCACAAAA

AAGATTAAATTAAACTTTGGGATTCCGACTCTTGCTGATGGATGGAGCAAGTCCAAG

GAGTACTCTAATAACGCCATTATCTTGATGCGTGACAACCTGTACTACCTGGGCATT

TTTAACGCTAAAAACAAACCCGACAAAAAGATCATTGAAGGGAACACCTCGGAAAA

TAAGGGGGACTATAAAAAAATGATCTACAATCTGTTGCCAGGCCCAAATAAGATGA

TCCCAAAGGTTTTTTTATCTTCCAAAACTGGCGTAGAAACTTACAAGCCGAGCGCAT

AC ATCCTTGAAGGAT ATAAACAAAAC AAACATATC AAAAGTTC AAAGGACTTCGAT

ATTACGTTCTGCCATGATTTAATCGATTATTTCAAGAATTGCATCGCGATTCACCCA G

AGTGGAAAAACTTTGGGTTTGATTTTTCAGACACCAGCACTTACGAGGATATTAGTG

GATTCTATCGTGAGGTTGAACTGCAGGGCTATAAAATTGACTGGACCTATATTTCTG

AAAAAGATATTGATCTGCTTCAGGAGAAAGGCCAATTGTACTTATTTCAAATCTATA

ACAAGGATTTCTCCAAGAAGTCCACGGGTAATGACAACTTACACACAATGTATCTGA

AGAATCTGTTTAGTGAGGAGAACTTGAAGGACATTGTGCTGAAGCTTAATGGCGAG

GCCGAAATCTTTTTTCGTAAGTCCTCCATTAAAAACCCTATTATCCATAAGAAAGGG

AGTATTCTTGTCAACCGCACGTATGAGGCCGAAGAAAAGGACCAATTCGGAAACAT

CCAAATTGTCCGTAAAAATATTCCTGAGAACATTTACCAGGAGCTTTACAAGTATTT

CAACGACAAGAGTGATAAAGAACTTTCAGATGAGGCGGCGAAACTGAAGAATGTAG

TGGGGCACCACGAAGCTGCCACGAATATTGTAAAGGATTACCGTTACACCTACGAC

AAGTACTTTTTGCATATGCCCATCACAATTAATTTTAAGGCCAATAAAACTGGTTTT A

TCAACGATCGTATCTTACAGTACATTGCTAAGGAAAAAGATCTGCACGTTATCGGTA

TCGATCGCGGGGAACGCAATCTGATTTATGTTAGTGTGATTGACACGTGCGGAAATA

TTGTTGAGCAGAAGAGCTTTAATATCGTAAATGGATATGACTATCAAATTAAACTGA

AGCAACAGGAAGGGGCCCGCCAGATTGCCCGCAAGGAGTGGAAAGAAATTGGAAA

GATCAAGGAGATTAAAGAAGGGTACCTTTCCCTTGTTATCCACGAAATCTCGAAAAT

GGTGATCAAGTACAATGCCATTATTGCTATGGAGGATCTGTCATATGGGTTTAAGAA

AGGCCGCTTTAAGGTGGAACGTCAGGTTTACCAGAAGTTTGAGACCATGCTTATCAA

TAAGCTGAATTATCTTGTCTTCAAAGACATCTCAATCACAGAGAACGGCGGGCTGTT

AAAAGGATATCAGCTGACCTATATCCCCGACAAACTGAAAAATGTCGGGCACCAAT

GCGGCTGTATTTTCTACGTGCCCGCTGCATACACATCTAAAATTGACCCAACGACTG

GATTCGTAAATATTTTTAAGTTTAAGGATCTTACGGTAGATGCAAAGCGCGAATTTA

TCAAGAAATTTGATAGTATCCGTTACGACAGCGAGAAAAACTTATTTTGTTTTACGT

TCGATTATAACAACTTCATCACGCAAAATACCGTCATGTCAAAATCTTCCTGGTCAG

TCTATACGTATGGCGTCCGTATCAAGCGCCGCTTCGTCAACGGGCGTTTTTCAAACG

AGTCAGATACCATCGATATCACCAAAGATATGGAAAAAACATTGGAGATGACGGAC

ATCAATTGGCGCGATGGTCATGACTTACGCCAGGACATTATTGACTACGAAATCGTA CAACATATTTTTGAGATTTTCCGTCTGACCGTGCAAATGCGCAACTCATTATCCGAA

CTTGAGGATCGTGATTACGACCGCTTGATCAGTCCTGTTCTGAACGAGAATAATATT

TTTTACGACAGTGCCAAGGCGGGAGACGCACTGCCCAAGGACGCTGACGCTAACGG

AGCTTATTGTATTGCGTTGAAGGGACTTTACGAAATCAAGCAAATCACTGAAAACTG

GAAGGAGGATGGTAAATTCTCACGCGACAAGTTGAAAATTTCGAACAAGGACTGGT

TCGATTTCATCCAAAACAAGCGTTATTTAAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0113] SEQ ID NO: 68

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGGA

CTAATAACTTCCAGAACTTCATCGGTATTTCATCATTACAAAAAACGCTTCGTAACG

CCTTGATCCCAACAGAAACGACCCAACAATTTATTGTAAAAAACGGCATCATCAAA

GAAGACGAACTGCGTGGCGAAAATCGCCAAATTTTGAAGGACATTATGGATGACTA

TTATCGTGGGTTTATCTCGGAGACATTATCCTCCATCGACGACATTGATTGGACGAG

TCTTTTTGAGAAAATGGAGATCCAGCTTAAAAATGGTGATAACAAGGATACATTGAT

CAAGGAGCAAACCGAGTACCGCAAGGCCATCCATAAGAAGTTCGCAAATGACGACC

GCTTCAAAAATATGTTTAGTGCCAAATTGATCTCGGATATCCTTCCTGAGTTCGTAA T

TCACAACAATAATTATAGCGCATCCGAAAAGGAGGAAAAGACTCAAGTCATTAAGC

TTTTCAGTCGCTTTGCTACCTCGTTTAAGGACTATTTCAAGAACCGCGCGAACTGCT T

CTCAGCGGATGACATTTCTTCCTCGTCGTGTCACCGCATCGTGAATGATAATGCGGA

GATCTTCTTTAGTAATGCCTTGGTATACCGCCGCATTGTTAAATCCCTGTCTAACGA C

GATATCAATAAGATCTCAGGAGATATGAAGGATAGCCTTAAAGAAATGTCTCTGGA

AGAAATTTACTCCTATGAAAAGTACGGTGAGTTTATCACCCAAGAGGGGATTAGCTT

TTATAACGATATCTGCGGGAAGGTGAATTCGTTTATGAACCTTTATTGTCAAAAGAA

TAAGGAGAATAAGAACTTATATAAGCTTCAGAAACTGCATAAACAAATCTTATGCA

TTGCCGATACTAGCTATGAAGTTCCGTATAAATTCGAGAGCGATGAAGAAGTTTATC

AGAGCGT CAATGGGTT CTTGGAT AAC ATTTC AT C AAAACAC ATCGT GGAACGTCTGC

GTAAGATTGGGGATAACTACAACGGATATAATCTTGACAAAATTTATATTGTATCTA

AATTCTATGAGTCGGTGAGTCAAAAGACCTACCGTGATTGGGAAACAATCAATACC

GCGTTAGAAATCCACTATAACAACATTCTGCCAGGGAATGGTAAAAGTAAAGCGGA

CAAAGTCAAGAAGGCTGTGAAGAACGATCTGCAAAAGAGTATTACAGAGATTAACG

AATTAGTCTCCAATTATAAGTTATGCTCGGACGATAACATTAAGGCGGAGACGTATA

TTCATGAGATTTCGCATATTCTTAACAACTTCGAGGCACAAGAGCTTAAGTATAACC

CAGAGATTCACCTTGTCGAATCGGAGCTGAAGGCATCGGAATTAAAAAATGTCTTA

GATGTAATCATGAACGCGTTCCATTGGTGCAGTGTTTTCATGACTGAGGAGTTAGTT GACAAGGACAATAACTTCTACGCAGAATTAGAAGAGATCTATGATGAGATTTATCC

AGTGATTTCGCTGTATAATCTGGTACGTAATTACGTCACTCAAAAGCCCTACTCAAC

AAAAAAAATTAAGCTGAACTTCGGAATTCCGACTCTGGCCGACGGGTGGTCCAAGT

CAAAGGAGTATTCTAATAATGCTATCATCCTGATGCGCGATAACTTATACTATTTGG

GAATTTTCAATGCCAAAAATAAACCAGATAAAAAGATTATCGAAGGTAATACAAGC

GAGAATAAGGGTGACTATAAGAAAATGATTTACAATCTTCTTCCAGGCCCTAACAA

GATGATTCCCAAAGTTTTTTTGTCCAGTAAAACAGGGGTCGAAACTTACAAGCCCAG

TGCCTATATCCTTGAAGGGTACAAGCAGAATAAGCACATCAAATCCTCGAAAGACTT

TGATATTACATTTTGTCATGACTTAATCGATTATTTTAAGAACTGTATCGCAATCCA T

CCAGAATGGAAGAACTTCGGGTTTGATTTCTCTGATACTTCCACGTATGAGGATATT

TCCGGGTTCTACCGCGAAGTAGAGCTTCAGGGCTATAAAATTGACTGGACATATATT

TCAGAAAAAGACATCGATCTGTTACAAGAAAAAGGACAGTTGTATCTGTTTCAAATC

TATAATAAGGATTTCTCCAAAAAGTCAACTGGAAATGATAACTTACATACAATGTAT

CTGAAAAATCTTTTTAGTGAAGAGAATTTGAAGGATATCGTGCTGAAGTTAAATGGC

GAAGCAGAGATCTTCTTCCGCAAGTCCTCGATCAAGAATCCTATCATCCACAAGAAA

GGTAGTATTCTGGTTAACCGCACGTACGAGGCCGAGGAAAAAGACCAGTTCGGTAA

TATCCAGATTGTACGTAAGAATATTCCTGAAAATATTTACCAGGAATTATACAAGTA

TTTTAACGACAAATCGGATAAGGAGCTTTCAGATGAGGCCGCAAAGTTGAAGAACG

TCGTAGGACACCATGAGGCCGCTACGAATATCGTCAAGGACTACCGCTATACGTATG

ACAAGTACTTCCTGCACATGCCTATTACTATCAATTTCAAAGCTAATAAAACAGGAT

TCATCAATGATCGTATCCTTCAGTACATTGCCAAAGAAAAAGATCTGCACGTAATCG

GAATCGACCGTGGCGAACGTAATCTGATTTACGTATCAGTTATCGACACATGTGGTA

ACATCGTGGAGCAGAAATCTTTTAACATTGTTAACGGCTATGATTATCAGATTAAGC

TTAAACAGCAGGAGGGGGCACGCCAAATCGCTCGTAAAGAATGGAAGGAGATTGG

AAAGATTAAAGAGATTAAAGAGGGGTACCTTTCGCTGGTTATTCACGAAATTTCCAA

GATGGTGATTAAGTACAATGCAATCATCGCGATGGAAGATCTTAGTTACGGATTCAA

AAAGGGACGCTTCAAAGTTGAGCGTCAGGTCTACCAGAAATTTGAAACGATGCTGA

TTAACAAATTGAATTACTTGGTATTCAAAGATATCTCAATTACTGAAAATGGTGGCT

TATTAAAGGGTTACCAGCTTACCTATATCCCGGATAAGCTGAAGAACGTGGGCCATC

AATGCGGCTGCATCTTTTACGTCCCTGCCGCATATACCTCTAAAATTGACCCCACCA

CCGGATTCGTAAATATTTTTAAATTCAAGGACCTGACGGTGGACGCCAAGCGCGAAT

TCATCAAAAAATTCGACTCAATCCGCTATGATTCCGAAAAAAATCTTTTCTGCTTTA C

GTTCGATTATAATAACTTCATTACCCAAAACACGGTGATGTCAAAATCGTCCTGGAG

CGTGTATACTTATGGAGTGCGTATCAAGCGCCGCTTTGTTAATGGGCGCTTCAGTAA

CGAAAGCGATACCATCGACATTACCAAAGACATGGAGAAGACGCTTGAAATGACGG ATATCAATTGGCGTGACGGACACGATCTTCGTCAGGATATCATCGACTACGAGATTG

TGCAACATATCTTTGAGATTTTCCGTTTAACTGTTCAAATGCGTAACTCCTTGTCCG A

ATTGGAAGACCGTGATTACGACCGCTTGATTTCACCAGTGCTTAACGAGAATAACAT

CTTCTACGACTCCGCCAAAGCAGGCGATGCCCTGCCAAAGGACGCTGATGCAAATG

GTGCATACTGTATCGCGTTGAAGGGCTTATACGAGATTAAGCAAATCACCGAAAATT

GGAAAGAGGATGGAAAGTTCAGTCGCGATAAGCTGAAGATCTCTAATAAAGATTGG

TTTGACTTTATCCAGAACAAACGTTATTTAAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0114] SEQ ID NO: 69

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGTA

CCAATAATTTCCAAAATTTCATCGGAATCTCATCCTTGCAAAAAACCTTGCGCAATG

CTTTGATCCCCACCGAAACCACGCAGCAGTTCATCGTGAAAAACGGCATTATCAAAG

AGGATGAGTTGCGCGGGGAAAACCGTCAAATTCTTAAGGATATCATGGACGATTAC

TACCGTGGGTTTATCAGTGAGACCCTGTCAAGCATTGACGACATTGACTGGACCAGC

TTATTTGAGAAGATGGAGATTCAATTAAAGAACGGGGACAATAAGGACACGCTTAT

CAAAGAGCAGACAGAATACCGTAAAGCGATTCATAAGAAATTTGCAAATGACGATC

GCTTCAAGAACATGTTTTCAGCAAAATTAATCAGCGACATCCTTCCCGAATTTGTGA

TTCATAATAACAACTATTCGGCTAGCGAAAAAGAGGAGAAAACTCAGGTTATTAAG

CTTTTCTCGCGTTTTGCCACTTCGTTCAAAGACTATTTTAAGAATCGCGCAAACTGC T

TTTCGGCTGATGATATTTCCAGTTCTAGCTGCCATCGTATCGTTAACGATAATGCTG A

GATTTTCTTCTCTAATGCCCTGGTGTATCGTCGTATCGTTAAATCTTTGAGCAACGA C

GATATTAATAAGATTTCAGGCGACATGAAGGATTCTTTAAAGGAGATGTCTTTAGAA

GAGATTTATTCCTATGAGAAATATGGCGAGTTTATCACCCAAGAAGGAATTTCGTTC

TACAACGACATCTGTGGCAAAGTGAACAGCTTCATGAATTTATACTGCCAAAAGAAT

AAGGAGAATAAAAATTTATATAAACTGCAGAAACTGCATAAGCAAATTCTTTGCATT

GCAGACACCTCTTATGAAGTTCCTTATAAGTTTGAATCGGACGAGGAGGTATATCAG

AGTGTGAACGGGTTCCTGGACAATATTTCATCCAAGCATATTGTTGAACGTTTACGC

AAAATTGGAGACAATTACAATGGGTATAACCTTGACAAAATTTACATCGTGTCGAA

GTTTTACGAATCGGTAAGCCAGAAGACCTATCGTGACTGGGAAACTATCAATACCGC

CTTAGAAATTCATTACAACAATATTCTTCCTGGTAACGGCAAAAGCAAAGCCGATAA

GGTAAAGAAGGCTGTCAAGAACGACCTGCAAAAGTCTATCACAGAGATCAACGAGT

TAGTCTCTAACTACAAATTATGTTCCGACGACAATATTAAAGCCGAAACCTACATCC

ATGAGATCTCACACATTCTTAACAATTTTGAGGCCCAGGAGCTGAAATATAACCCAG

AAATTCACCTTGTAGAGAGCGAATTAAAAGCCTCCGAGCTGAAGAACGTTTTGGAT GTAATCATGAACGCATTTCATTGGTGCAGCGTATTTATGACAGAGGAGTTGGTCGAC

AAGGACAATAACTTTTACGCCGAGCTTGAAGAAATCTACGATGAAATTTACCCGGTA

ATTAGTTTATATAATTTAGTTCGCAACTACGTAACTCAGAAACCCTACAGTACCAAG

AAGATTAAATTGAACTTTGGGATCCCGACACTTGCTGACGGTTGGAGTAAATCAAAA

GAATACTCCAATAATGCAATTATCCTGATGCGCGACAATCTTTACTACTTGGGGATC

TTTAACGCAAAGAACAAACCAGATAAGAAAATCATCGAGGGCAACACCAGCGAGA

ATAAAGGCGATTACAAGAAAATGATCTATAATCTTTTGCCGGGACCGAACAAAATG

ATCCCAAAGGTTTTCCTGTCGTCGAAAACGGGAGTCGAGACATATAAACCATCTGCG

TACATCTTGGAAGGTTACAAACAGAATAAGCATATTAAGTCTAGTAAAGACTTCGAC

ATCACCTTTTGTCATGACCTGATTGATTATTTCAAGAACTGTATTGCTATCCATCCA G

AATGGAAAAACTTCGGATTTGACTTCTCCGATACTAGCACCTACGAAGACATTTCGG

GTTTTTATCGCGAAGTAGAGCTTCAAGGGTACAAAATTGATTGGACATATATTAGCG

AGAAAGACATTGATTTGCTTCAAGAGAAGGGACAGTTATATTTATTCCAGATCTACA

ACAAAGACTTCTCGAAGAAATCCACCGGTAATGATAATCTTCACACTATGTACCTGA

AGAATTTATTTTCAGAGGAAAATCTGAAGGACATTGTACTTAAACTTAATGGAGAAG

CCGAAATCTTCTTCCGCAAGAGTTCCATTAAAAATCCGATTATTCATAAAAAGGGAA

GTATCCTTGTGAACCGCACGTATGAGGCCGAAGAGAAGGATCAGTTTGGGAATATT

CAAATTGTCCGCAAAAACATCCCCGAGAACATCTACCAGGAACTGTATAAATACTTT

AATGATAAATCTGATAAAGAGTTATCAGACGAGGCTGCCAAACTGAAAAACGTAGT

CGGTCATCATGAGGCAGCGACCAATATTGTAAAGGACTACCGTTACACCTACGACA

AGTATTTCCTTCACATGCCGATCACGATTAATTTTAAGGCTAACAAGACCGGCTTTA

TCAATGACCGCATCTTGCAGTACATCGCGAAAGAGAAAGATTTACACGTCATCGGA

ATTGATCGTGGAGAGCGTAATCTTATCTACGTCAGCGTCATCGACACCTGTGGAAAC

ATTGTGGAACAAAAAAGTTTTAATATCGTAAACGGCTACGACTATCAAATTAAACTT

AAACAGCAAGAGGGAGCTCGCCAGATCGCTCGCAAAGAGTGGAAAGAGATTGGGA

AAATTAAAGAAATTAAAGAGGGTTACCTGTCGCTGGTAATTCACGAAATCTCGAAA

ATGGTCATCAAATATAATGCAATTATCGCTATGGAGGATCTGTCCTACGGGTTCAAG

AAGGGACGTTTTAAAGTAGAGCGCCAGGTGTATCAAAAATTCGAAACCATGTTGAT

CAATAAGCTTAACTATTTGGTCTTCAAAGATATTTCGATTACGGAGAACGGAGGTTT

GTTGAAAGGATATCAGCTGACGTATATCCCAGACAAGTTGAAAAACGTGGGGCATC

AATGTGGATGTATTTTCTATGTGCCCGCGGCCTACACGAGTAAGATCGATCCTACCA

CTGGTTTCGTCAACATTTTCAAATTTAAAGATCTTACCGTGGATGCGAAGCGCGAAT

TTATTAAGAAATTTGATAGCATTCGCTATGATTCCGAAAAGAACCTGTTCTGTTTTA C

GTTCGACTATAACAATTTCATTACCCAAAACACGGTGATGAGCAAATCCTCTTGGTC

AGTTTATACATACGGTGTACGTATCAAACGCCGTTTCGTTAACGGACGCTTTTCCAA TGAGTCTGATACAATCGATATCACGAAAGATATGGAAAAAACATTAGAGATGACTG

ATATCAACTGGCGTGACGGGCACGACCTGCGTCAAGACATTATTGACTACGAGATTG

TGCAGCATATCTTCGAAATCTTTCGCTTAACTGTGCAAATGCGTAACTCGTTATCCG A

GTTAGAAGACCGTGACTACGATCGCCTGATTTCACCCGTCTTGAACGAAAATAACAT

CTTCTACGATTCCGCGAAGGCTGGGGACGCATTGCCCAAGGACGCAGACGCGAATG

GAGCGTACTGTATTGCGCTTAAAGGATTATATGAAATCAAGCAGATCACCGAAAATT

GGAAGGAGGACGGGAAGTTCTCACGCGACAAACTGAAGATTTCAAATAAGGACTGG

TTCGATTTCATTCAGAATAAGCGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0115] SEQ ID NO: 70

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGTA

CGAACAACTTTCAGAACTTCATCGGCATCTCCAGCCTTCAAAAGACTTTACGCAACG

CATTGATTCCCACGGAGACTACGCAACAGTTTATCGTAAAAAATGGTATTATCAAAG

AAGATGAATTACGCGGGGAGAATCGCCAGATTCTTAAGGACATTATGGACGATTAT

TACCGTGGATTCATCAGTGAGACACTGAGCTCCATTGATGACATCGACTGGACGTCA

TTGTTTGAAAAGATGGAAATCCAGTTGAAAAATGGCGATAACAAAGATACATTGAT

TAAAGAGCAGACAGAGTACCGCAAAGCAATTCACAAGAAATTCGCCAATGATGATC

GTTTTAAGAACATGTTTAGTGCCAAGCTTATTTCGGATATCTTACCCGAATTCGTGA T

TCACAACAACAATTATTCGGCAAGTGAGAAAGAGGAAAAGACCCAGGTTATCAAAT

TGTTTTCGCGCTTCGCCACTTCGTTCAAAGATTATTTCAAGAACCGTGCAAACTGTT T

CTCCGCTGACGACATCAGTTCCAGCTCATGCCACCGTATTGTAAATGACAATGCGGA

GATCTTTTTCAGTAATGCCTTAGTATATCGTCGCATTGTAAAGAGCTTATCTAATGA T

GACATTAACAAGATCTCGGGTGATATGAAGGACTCACTTAAGGAGATGAGTCTGGA

AGAGATCTACTCCTACGAAAAATACGGGGAATTCATCACCCAGGAGGGAATTTCAT

TCTACAACGATATCTGCGGCAAAGTTAACTCCTTTATGAATCTGTACTGTCAAAAGA

ACAAGGAGAATAAAAACCTGTATAAATTGCAGAAACTTCATAAACAAATTTTGTGT

ATCGCAGACACGAGTTATGAAGTACCTTATAAATTCGAATCCGACGAAGAGGTATA

TCAGTCCGTAAATGGGTTCCTGGACAATATCAGTAGTAAGCACATTGTGGAACGCTT

ACGCAAAATTGGAGACAATTACAACGGGTATAACCTGGACAAAATCTACATCGTAT

CCAAATTTTATGAAAGCGTGTCTCAAAAAACTTATCGTGATTGGGAAACAATCAACA

CGGCTCTTGAGATCCATTACAATAACATCTTGCCGGGTAACGGCAAATCGAAGGCA

GACAAAGTTAAAAAAGCAGTTAAGAACGACTTACAGAAAAGCATTACGGAGATTAA

CGAGTTAGTAAGTAATTACAAATTATGCTCCGACGATAATATCAAAGCTGAAACCTA

CATCCATGAAATTAGCCACATTTTGAACAATTTCGAAGCGCAGGAGCTGAAATATAA CCCTGAAATCCATCTGGTAGAGTCTGAGTTGAAGGCGTCAGAACTGAAAAACGTTCT

TGACGTCATCATGAATGCCTTTCACTGGTGTAGTGTTTTTATGACTGAGGAGCTTGT A

GATAAGGACAACAACTTCTATGCTGAACTTGAAGAGATCTACGATGAAATCTACCCC

GTAATCAGTCTGTATAATTTAGTTCGTAACTACGTCACGCAGAAACCCTATTCGACT

AAGAAAATTAAGCTGAACTTTGGGATCCCTACTTTGGCAGACGGGTGGAGCAAGAG

TAAAGAATACAGTAATAATGCAATTATCTTGATGCGCGATAACTTATATTACTTAGG

TATTTTCAATGCTAAGAACAAACCTGATAAGAAGATTATCGAAGGAAATACGAGTG

AGAATAAGGGAGACTACAAAAAGATGATTTACAACTTGCTGCCAGGGCCTAATAAG

ATGATTCCAAAAGTTTTTCTGTCGAGCAAGACAGGGGTTGAAACTTATAAGCCATCC

GCTTATATCCTTGAGGGGTACAAGCAGAATAAGCATATCAAGTCCTCCAAAGATTTT

GATATTACATTTTGCCACGACTTAATTGATTACTTCAAGAACTGCATCGCAATCCAT C

CCGAATGGAAGAATTTCGGCTTCGATTTCTCAGATACGTCCACGTATGAGGATATCT

CAGGCTTTTACCGCGAAGTTGAGCTGCAAGGTTATAAAATTGATTGGACATACATCT

CCGAAAAAGACATTGATCTTTTACAGGAAAAGGGCCAATTATACTTATTTCAAATCT

ATAACAAAGATTTTAGCAAGAAGTCCACAGGTAATGATAACCTGCATACGATGTATT

TGAAAAATCTTTTCAGTGAAGAGAATTTGAAGGATATCGTCCTGAAGCTGAACGGTG

AGGCTGAGATCTTCTTCCGCAAATCGTCTATCAAAAACCCCATCATTCACAAAAAGG

GAAGTATCTTAGTAAACCGCACTTATGAAGCGGAGGAAAAGGATCAGTTCGGGAAC

ATCCAGATCGTGCGCAAGAACATTCCAGAAAACATCTATCAGGAACTTTACAAATAT

TTCAATGACAAGTCTGATAAAGAATTATCAGACGAGGCGGCGAAACTTAAAAATGT

TGTTGGACACCACGAAGCAGCGACGAATATTGTAAAGGATTATCGCTACACATACG

ATAAATACTTTTTGCACATGCCAATCACCATTAACTTTAAGGCGAACAAGACAGGTT

TCATTAACGACCGTATTCTGCAATATATCGCAAAGGAAAAAGACCTGCACGTTATTG

GGATCGATCGTGGCGAACGCAATTTGATCTACGTAAGCGTTATCGACACTTGCGGAA

ATATCGTTGAACAAAAAAGCTTTAATATCGTCAATGGATACGATTACCAAATCAAGC

TGAAACAACAAGAAGGGGCACGTCAGATCGCTCGTAAAGAATGGAAAGAGATTGGT

AAGATCAAAGAGATTAAAGAAGGGTATCTTTCTTTAGTAATTCACGAGATTTCGAAA

ATGGTTATTAAATACAATGCGATTATTGCTATGGAAGACTTAAGCTACGGCTTTAAG

AAAGGTCGCTTCAAAGTGGAGCGCCAAGTGTATCAGAAGTTTGAAACGATGTTGAT

TAACAAATTAAATTACCTGGTCTTTAAGGACATCAGTATCACAGAAAATGGGGGGTT

GCTTAAAGGGTACCAGCTTACATACATCCCTGATAAACTGAAAAATGTCGGTCATCA

GTGCGGATGTATCTTCTATGTACCAGCAGCCTATACCAGTAAGATTGACCCTACTAC

TGGCTTTGTGAATATTTTTAAATTCAAGGATTTAACCGTGGACGCCAAGCGTGAATT

TATTAAAAAATTTGATTCGATTCGCTACGACAGTGAGAAAAACCTTTTCTGCTTTAC

CTTTGACTACAACAATTTTATTACCCAGAACACCGTAATGTCAAAGAGTTCGTGGTC TGTATATACCTACGGTGTTCGCATCAAGCGCCGCTTCGTAAACGGGCGTTTCAGTAA

CGAATCTGACACCATCGACATCACTAAAGATATGGAGAAGACATTGGAAATGACGG

ACATTAATTGGCGTGATGGCCATGACTTACGTCAGGACATTATTGATTACGAAATTG

TGCAGCATATCTTCGAGATTTTCCGTTTGACAGTTCAGATGCGCAACTCACTGAGTG

AGTTAGAAGATCGCGATTACGACCGTCTGATCTCACCGGTCCTTAATGAAAACAACA

TTTTCTACGACTCAGCAAAGGCGGGTGATGCCCTGCCAAAGGATGCGGACGCTAAT

GGCGCCTACTGCATCGCCCTGAAAGGATTGTATGAAATTAAGCAGATTACAGAAAA

TTGGAAGGAAGATGGTAAATTTAGCCGTGATAAATTAAAAATCTCGAACAAGGATT

GGTTCGATTTTATTCAGAACAAACGTTATTTGAAACGTCCGGCAGCGACCAAAAAAG

CCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAA

GAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0116] SEQ ID NO: 71

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGAA

CAAATAATTTTCAAAATTTTATCGGCATCTCAAGTCTTCAAAAAACCCTTCGCAATG

CCCTGATTCCAACTGAAACAACCCAGCAATTTATCGTCAAGAACGGCATCATTAAGG

AAGACGAGTTACGCGGGGAGAACCGTCAAATCCTGAAAGATATCATGGATGACTAC

TATCGTGGGTTCATTTCGGAAACCTTGTCTTCAATCGACGACATTGACTGGACGAGT

CTTTTCGAGAAAATGGAAATTCAGCTTAAAAATGGAGACAACAAGGATACTCTGAT

TAAGGAACAGACAGAATATCGCAAAGCTATCCACAAAAAGTTCGCTAATGATGATC

GTTTCAAAAATATGTTTTCTGCTAAATTGATTTCCGATATCTTGCCTGAATTTGTAA T

CCACAACAACAATTATTCTGCTTCCGAGAAGGAAGAGAAGACCCAGGTCATTAAAT

TATTCAGCCGCTTTGCAACCAGCTTTAAAGACTACTTTAAGAATCGCGCTAACTGCT

TTTCGGCGGATGACATCTCATCATCATCATGCCACCGCATTGTGAACGACAATGCGG

AGATCTTCTTTTCGAATGCGTTAGTTTATCGTCGCATTGTCAAAAGTCTTAGCAATG A

TGACATCAACAAGATCTCAGGAGACATGAAAGATTCCTTAAAGGAGATGTCTCTTG

AGGAAATCTATTCGTATGAGAAATACGGCGAGTTCATTACCCAGGAAGGTATTAGTT

TCTACAATGATATCTGCGGCAAAGTAAATTCTTTTATGAATCTGTATTGCCAAAAAA

ACAAAGAAAACAAGAATCTTTATAAGTTACAAAAGTTACATAAGCAAATTCTGTGC

ATCGCTGATACATCTTATGAGGTACCCTACAAATTTGAAAGTGATGAGGAGGTCTAT

CAGAGTGTCAACGGCTTCTTAGACAACATCTCTTCCAAACATATCGTGGAACGCCTG

CGTAAAATCGGAGATAACTACAACGGATATAACTTAGATAAAATCTACATCGTGTCC

AAGTTTTATGAAAGTGTGAGCCAAAAAACATATCGTGACTGGGAAACCATTAACAC

CGCATTGGAAATTCACTATAACAACATTTTGCCAGGCAACGGGAAAAGTAAGGCGG

ACAAAGTTAAGAAAGCAGTTAAAAATGACCTGCAAAAAAGCATCACTGAAATTAAC

GAATTGGTATCGAATTACAAATTATGTAGCGACGATAATATCAAAGCAGAAACTTA CATTCACGAGATTAGTCACATTTTAAATAACTTCGAGGCCCAGGAATTGAAATACAA

TCCCGAAATTCATTTGGTTGAATCAGAACTGAAAGCATCAGAGTTGAAAAATGTGTT

AGATGTCATTATGAATGCGTTTCATTGGTGCTCTGTGTTCATGACCGAGGAACTGGT

TGATAAAGATAACAACTTTTACGCTGAATTGGAGGAGATTTACGATGAGATTTACCC

GGTCATTTCGCTTTATAACTTAGTGCGCAATTATGTGACGCAGAAACCATATTCCAC

GAAGAAAATCAAACTTAATTTTGGCATCCCTACTCTGGCTGATGGTTGGTCGAAATC

GAAAGAGTACAGCAACAACGCGATCATTCTTATGCGTGACAATCTTTACTATTTGGG

CATTTTTAATGCCAAGAATAAGCCAGATAAGAAAATCATTGAGGGGAATACTTCCG

AGAATAAGGGGGATTACAAAAAGATGATCTATAACTTGCTGCCCGGCCCCAACAAA

ATGATTCCTAAGGTTTTCTTGTCAAGCAAGACGGGCGTCGAAACATATAAGCCGTCA

GCTTATATTCTGGAAGGCTATAAACAGAATAAGCACATCAAGTCTTCCAAGGACTTT

GACATCACTTTTTGCCACGATTTGATCGACTACTTTAAGAACTGTATTGCGATTCAT C

CGGAATGGAAGAACTTCGGTTTCGACTTTTCCGATACCTCAACATACGAGGATATCA

GCGGCTTCTACCGTGAAGTCGAGCTTCAAGGCTACAAGATCGATTGGACATATATTT

CAGAGAAGGACATTGATTTGTTACAAGAGAAAGGTCAACTTTACTTATTTCAGATCT

ATAACAAAGACTTTTCGAAGAAATCGACAGGAAACGATAACTTACACACTATGTAT

TTAAAAAATCTGTTTTCGGAGGAAAACCTGAAAGATATTGTGCTGAAACTTAACGGC

GAGGCAGAGATCTTTTTCCGTAAAAGCTCAATCAAGAATCCTATCATCCATAAAAAA

GGTAGTATTCTTGTCAACCGCACATATGAAGCGGAGGAGAAGGACCAATTCGGAAA

CATCCAAATTGTCCGTAAGAATATTCCGGAGAACATTTACCAAGAGTTGTATAAATA

CTTTAACGATAAGTCAGATAAGGAACTTAGCGATGAGGCGGCGAAGCTTAAAAACG

TAGTTGGGCATCATGAAGCTGCTACCAACATTGTAAAAGATTACCGTTACACCTATG

ACAAGTATTTCTTGCACATGCCCATTACGATCAATTTCAAAGCAAATAAGACAGGCT

TTATCAATGATCGCATCCTGCAGTACATTGCTAAAGAGAAGGATTTGCATGTTATCG

GTATTGATCGCGGAGAGCGCAATTTGATCTACGTCTCCGTAATCGACACTTGCGGTA

ACATTGTTGAGCAGAAGTCGTTCAACATCGTTAATGGTTATGATTACCAAATCAAGC

TGAAGCAGCAAGAGGGTGCCCGCCAGATCGCGCGTAAGGAATGGAAAGAAATCGG

GAAAATTAAAGAGATCAAAGAAGGCTATTTGTCTCTGGTAATTCACGAAATCAGCA

AGATGGTGATCAAGTATAACGCGATCATTGCGATGGAGGATCTTTCTTATGGCTTCA

AGAAAGGGCGCTTTAAAGTCGAACGCCAGGTCTACCAGAAATTTGAGACAATGCTT

ATCAACAAGCTTAACTATCTTGTATTTAAGGATATTTCCATCACTGAGAACGGAGGA

CTTTTAAAGGGGTACCAACTGACGTACATTCCTGATAAGCTGAAGAACGTTGGTCAT

CAATGCGGATGCATCTTCTATGTGCCAGCGGCTTACACCTCCAAAATCGATCCCACT

ACAGGCTTTGTCAATATCTTCAAATTCAAGGATTTGACCGTTGACGCGAAGCGCGAG

TTTATCAAGAAGTTTGATAGCATTCGCTACGACAGCGAAAAAAATTTATTTTGTTTT ACTTTCGACTACAATAACTTTATTACTCAGAACACTGTCATGTCAAAGAGTTCGTGG

AGTGTCTACACGTACGGAGTACGTATTAAGCGCCGTTTCGTCAACGGACGCTTCTCA

AACGAAAGCGACACGATCGACATCACCAAAGACATGGAAAAAACTCTTGAGATGAC

GGATATCAATTGGCGCGACGGCCATGACCTGCGTCAGGATATCATTGATTACGAGAT

CGTTCAGCACATCTTCGAAATCTTCCGCCTTACCGTCCAGATGCGCAACAGTTTAAG

CGAGCTTGAAGACCGCGACTACGATCGTTTGATTAGCCCCGTTCTGAACGAGAATAA

TATTTTCTACGACAGCGCAAAGGCCGGTGATGCTTTGCCAAAGGACGCAGACGCGA

ATGGAGCCTACTGCATCGCCCTGAAGGGCTTATATGAGATTAAGCAAATTACCGAA

AATTGGAAGGAAGATGGTAAGTTCTCCCGTGATAAGCTTAAAATTAGCAATAAGGA

TTGGTTCGACTTCATCCAGAACAAACGTTACCTGAAACGTCCGGCAGCGACCAAAA

AAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAA

AAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0117] SEQ ID NO: 72

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAA

CAAACAATTTCCAAAACTTCATCGGTATCTCTTCGTTGCAGAAGACTCTGCGTAATG

CTTTGATCCCGACGGAGACAACCCAACAATTTATCGTCAAAAACGGTATTATTAAGG

AGGACGAGTTACGTGGAGAAAATCGTCAAATCCTTAAGGACATCATGGACGATTAT

TATCGCGGGTTTATTTCTGAAACCCTGAGCAGTATCGATGATATCGACTGGACCTCA

CTTTTTGAGAAAATGGAGATCCAGTTGAAGAACGGTGATAACAAAGACACTCTGAT

CAAAGAGCAAACTGAATACCGCAAGGCAATTCACAAAAAGTTCGCCAACGACGACC

GTTTCAAGAATATGTTCTCAGCTAAGTTAATCAGCGACATTTTGCCAGAGTTCGTTA T

CCACAACAATAATTATAGTGCTTCAGAGAAGGAGGAAAAAACCCAAGTGATTAAAC

TTTTTTCGCGCTTTGCAACCTCATTCAAGGACTACTTCAAGAATCGCGCGAATTGCT T

CAGTGCGGACGACATTTCTTCTTCAAGTTGCCATCGTATCGTTAACGATAACGCGGA

AATTTTCTTCTCTAATGCTTTGGTGTATCGCCGCATTGTAAAATCGCTTAGTAACGA T

GACATTAATAAGATCTCAGGTGATATGAAAGATTCATTGAAGGAAATGAGCTTGGA

AGAGATTTACAGTTACGAAAAATATGGAGAATTTATTACTCAGGAAGGCATCTCATT

CTATAACGATATCTGCGGGAAGGTAAATTCGTTTATGAACTTATATTGCCAGAAAAA

TAAAGAGAATAAAAATTTGTATAAGCTTCAGAAGTTGCACAAACAGATCCTGTGCA

TTGCAGACACCTCGTATGAGGTTCCGTATAAATTTGAGTCCGATGAAGAAGTGTATC

AGTCTGTGAATGGTTTCTTAGATAATATCTCTTCCAAGCATATTGTCGAACGCCTGC G

CAAAATTGGTGATAACTATAACGGATACAATCTGGATAAAATTTACATCGTTTCTAA

ATTTTACGAGTCAGTCTCGCAGAAGACCTACCGCGACTGGGAAACAATTAACACGG

CATTGGAGATTCACTACAATAATATCTTGCCTGGTAACGGTAAGTCTAAGGCAGATA

AGGTAAAAAAAGCTGTGAAAAACGACCTTCAGAAAAGCATCACGGAGATTAATGAG CTGGTGAGTAATTACAAATTATGTTCAGACGATAATATTAAAGCTGAAACGTATATC

CATGAAATCTCGCATATCTTGAACAACTTCGAGGCCCAAGAACTTAAATATAACCCC

GAAATCCATTTAGTCGAGTCTGAATTGAAAGCGTCGGAATTAAAAAACGTCTTAGAC

GTCATTATGAACGCGTTTCACTGGTGTTCAGTTTTCATGACCGAAGAGCTGGTCGAC

AAAGACAACAACTTCTATGCGGAATTGGAGGAAATCTATGATGAAATCTACCCTGTT

ATTTCACTGTATAACCTTGTGCGCAACTATGTCACTCAGAAGCCGTATTCGACCAAA

AAAATTAAATTGAATTTCGGTATCCCTACTCTTGCAGACGGATGGAGTAAAAGCAAG

GAATACAGTAATAACGCCATTATTCTTATGCGCGACAATTTATACTACCTGGGCATC

TTTAACGCAAAGAATAAGCCGGATAAGAAGATTATTGAGGGTAACACCAGTGAGAA

CAAGGGCGACTATAAGAAGATGATCTATAACTTATTGCCAGGTCCAAATAAAATGA

TCCCAAAAGTATTCTTATCATCAAAGACGGGAGTTGAAACCTATAAGCCTAGTGCCT

ATATTCTTGAGGGATATAAACAGAACAAGCACATTAAGTCGTCTAAGGATTTTGACA

TTACGTTCTGCCATGACTTAATCGACTATTTTAAAAACTGTATTGCGATTCACCCCG A

ATGGAAGAATTTTGGATTCGATTTTTCGGATACCTCGACCTATGAAGATATTTCGGG

ATTTTATCGTGAAGTGGAGTTGCAAGGCTATAAAATCGATTGGACCTATATCTCAGA

AAAAGACATTGATTTATTACAGGAAAAGGGACAACTGTACCTTTTCCAAATTTATAA

CAAGGACTTTTCTAAAAAGTCCACAGGAAATGATAACCTTCACACCATGTACCTGAA

GAACCTTTTCTCAGAGGAAAACCTGAAGGACATTGTCCTTAAGTTAAATGGAGAAG

CGGAGATCTTTTTCCGTAAATCTAGTATCAAGAATCCGATTATCCATAAAAAAGGTT

CGATTTTGGTAAATCGCACCTATGAAGCGGAAGAGAAAGATCAATTTGGTAACATC

CAGATCGTGCGCAAGAATATCCCGGAGAACATTTACCAAGAGCTGTATAAGTACTTC

AATGATAAGTCTGATAAGGAACTGTCAGATGAAGCTGCGAAATTGAAGAACGTGGT

TGGGCATCATGAAGCCGCTACCAATATCGTCAAGGATTACCGTTATACCTATGACAA

ATATTTCTTACACATGCCGATTACGATCAATTTTAAGGCAAACAAGACAGGATTCAT

CAACGACCGTATCTTGCAGTATATTGCCAAAGAGAAGGATCTGCATGTGATCGGTAT

TGACCGCGGGGAGCGCAATTTAATCTATGTATCGGTGATCGATACTTGTGGTAACAT

CGTAGAACAAAAGAGCTTTAACATCGTGAATGGTTACGACTATCAGATCAAGCTGA

AACAACAGGAAGGAGCCCGCCAGATCGCTCGCAAGGAATGGAAAGAAATCGGGAA

AATTAAGGAAATCAAGGAAGGCTACCTTTCATTGGTCATTCACGAAATTTCGAAAAT

GGTAATTAAGTACAACGCGATCATCGCCATGGAGGACCTTTCGTACGGATTTAAGAA

GGGTCGTTTCAAAGTTGAGCGCCAGGTATACCAAAAATTCGAGACTATGCTTATCAA

CAAACTTAACTACTTGGTCTTTAAGGACATTTCTATTACCGAAAACGGCGGCTTACT

TAAAGGCTATCAATTGACATATATTCCCGACAAACTGAAGAATGTTGGACATCAATG

CGGGTGTATTTTCTATGTGCCGGCAGCTTACACTAGTAAGATCGACCCTACAACCGG

GTTCGTAAACATTTTTAAATTCAAAGACTTAACAGTCGATGCGAAGCGTGAATTTAT TAAGAAGTTTGATAGTATCCGCTATGACAGTGAAAAGAACTTGTTTTGCTTTACGTT

CGACTACAATAACTTTATTACACAGAACACGGTCATGTCTAAATCATCATGGTCGGT

TTACACATATGGGGTGCGCATCAAGCGTCGCTTTGTAAATGGCCGTTTTAGTAATGA

GAGCGACACAATCGACATCACAAAGGATATGGAGAAAACTCTTGAGATGACAGACA

TCAATTGGCGTGACGGTCATGACTTACGCCAAGATATCATCGACTACGAAATCGTAC

AGCATATTTTTGAGATTTTTCGTCTTACTGTGCAAATGCGTAATTCTTTATCCGAAC T

GGAAGATCGTGATTACGACCGCTTGATTAGTCCCGTCTTAAATGAGAACAATATTTT

CTATGATTCTGCGAAAGCCGGAGATGCACTGCCCAAAGACGCTGATGCCAATGGCG

CGTATTGCATTGCATTAAAAGGATTATATGAGATTAAACAGATTACCGAAAATTGGA

AAGAGGACGGTAAATTCTCACGCGATAAATTGAAGATTTCTAACAAGGACTGGTTC

GACTTTATCCAAAATAAACGTTATCTTAAACGTCCGGCAGCGACCAAAAAAGCCGG

CCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAAA

CGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0118] SEQ ID NO: 73

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGTA

CCAACAACTTTCAGAATTTCATTGGCATTAGCTCGCTTCAAAAAACTTTACGCAATG

CTCTTATTCCGACTGAGACGACACAACAGTTTATCGTTAAGAATGGCATCATCAAAG

AAGATGAATTACGCGGAGAAAACCGCCAGATCCTGAAAGACATTATGGACGATTAT

TACCGTGGGTTCATCTCCGAGACGTTGTCATCGATCGATGACATCGACTGGACGTCA

CTTTTTGAAAAAATGGAGATCCAGTTAAAGAACGGTGACAATAAGGATACATTGAT

CAAAGAACAGACCGAGTACCGTAAAGCGATTCATAAAAAGTTTGCGAACGATGATC

GCTTCAAGAATATGTTTTCTGCGAAATTAATTTCCGACATTTTACCTGAATTTGTTA T

TCATAATAACAACTACTCGGCGTCTGAGAAAGAGGAGAAAACCCAAGTGATTAAAC

TTTTTTCACGTTTCGCAACGTCGTTCAAAGACTATTTTAAAAATCGTGCTAATTGCT T

TAGCGCGGATGACATCAGCTCTAGTTCATGTCATCGCATTGTCAACGATAATGCTGA

GATCTTTTTCAGTAATGCGTTAGTGTACCGTCGTATTGTGAAGTCCTTATCTAATGA T

GATATCAATAAGATCAGCGGGGATATGAAGGACTCACTTAAGGAGATGAGCTTGGA

GGAAATCTATTCCTATGAGAAGTATGGTGAGTTTATTACGCAAGAAGGAATTAGCTT

TTACAACGATATCTGTGGAAAGGTGAATTCGTTTATGAATTTGTATTGCCAGAAAAA

TAAGGAGAACAAGAACCTTTATAAATTGCAAAAGTTACACAAGCAAATCCTGTGCA

TTGCAGATACTTCCTACGAGGTGCCTTACAAGTTTGAATCCGACGAAGAGGTCTACC

AATCTGTAAACGGTTTCTTAGATAATATTAGTTCCAAGCATATTGTGGAGCGCCTTC

GTAAAATTGGCGATAATTACAACGGTTACAATTTAGACAAAATTTACATTGTCAGTA

AATTCTACGAGTCCGTATCTCAAAAGACGTATCGTGATTGGGAGACTATCAATACGG

CCCTGGAGATCCACTACAACAATATCTTGCCCGGTAATGGTAAGTCGAAGGCCGATA AAGTTAAGAAAGCGGTGAAAAATGACTTACAGAAGTCAATCACCGAAATTAACGAA

TTGGTGTCCAATTATAAATTGTGTTCAGATGATAATATCAAAGCCGAGACCTACATT

CATGAGATTTCCCATATCTTAAATAATTTCGAGGCGCAAGAGCTTAAGTATAACCCA

GAAATCCACCTGGTAGAATCTGAGTTGAAGGCGTCAGAGTTAAAAAATGTTTTAGAT

GTCATTATGAACGCGTTTCACTGGTGCTCCGTATTTATGACGGAGGAATTAGTAGAT

AAAGACAACAATTTCTATGCCGAACTTGAGGAAATCTATGATGAGATCTATCCCGTC

ATTAGCCTGTATAACTTGGTCCGCAACTATGTTACCCAAAAACCGTACAGTACCAAG

AAGATTAAGCTGAATTTCGGCATTCCTACACTGGCTGATGGTTGGAGTAAATCGAAG

GAATATTCGAATAACGCGATTATCTTGATGCGCGACAACTTATACTATTTGGGGATC

TTTAACGCCAAAAACAAACCGGATAAGAAGATTATTGAGGGAAACACATCAGAGAA

CAAAGGCGACTACAAAAAAATGATTTACAACTTGTTACCGGGGCCTAACAAAATGA

TCCCGAAGGTGTTCTTATCCAGTAAAACAGGCGTTGAGACCTACAAACCTTCCGCAT

ACATCCTGGAAGGGTATAAGCAGAACAAGCACATTAAGTCCAGCAAGGATTTCGAT

ATTACCTTCTGTCATGATTTAATTGACTATTTCAAGAACTGTATTGCAATCCACCCC G

AGTGGAAGAACTTCGGATTCGACTTCTCAGATACGAGCACATATGAGGACATCTCG

GGGTTCTATCGTGAAGTAGAACTGCAGGGATATAAAATTGATTGGACATATATTTCC

GAAAAAGACATCGACCTTTTACAAGAGAAGGGTCAACTTTACTTGTTCCAAATTTAC

AATAAAGACTTCTCAAAAAAAAGCACGGGTAACGATAATTTACACACTATGTATTTA

AAGAACCTTTTCTCGGAAGAGAATTTAAAGGATATCGTATTGAAGTTGAATGGAGA

AGCGGAGATCTTCTTCCGTAAGTCCAGTATTAAAAACCCTATTATTCACAAGAAGGG

ATCGATTTTAGTTAACCGCACATACGAGGCCGAAGAGAAGGACCAATTTGGGAACA

TTCAAATTGTCCGCAAAAACATCCCTGAGAACATTTATCAAGAGCTTTATAAGTACT

TTAACGATAAGTCCGATAAGGAATTGTCAGATGAGGCGGCAAAGTTGAAGAATGTC

GTGGGGCATCATGAAGCTGCCACCAACATTGTGAAGGACTACCGCTACACTTACGA

CAAATACTTCCTGCACATGCCCATTACGATCAATTTTAAGGCCAATAAGACAGGCTT

TATTAACGACCGTATTCTTCAATATATCGCTAAGGAGAAGGACCTTCATGTGATTGG

GATCGACCGCGGAGAACGTAATTTAATTTATGTGTCCGTCATCGATACGTGTGGAAA

TATCGTGGAACAGAAATCATTCAATATCGTGAATGGCTATGATTACCAGATCAAATT

AAAACAGCAGGAGGGCGCTCGCCAAATTGCGCGTAAGGAATGGAAAGAGATCGGA

AAAATCAAAGAAATCAAAGAAGGATATTTGTCATTGGTGATCCATGAGATTTCAAA

AATGGTAATTAAATATAATGCAATTATCGCAATGGAAGACCTGTCCTATGGTTTTAA

GAAGGGTCGTTTCAAGGTAGAACGCCAAGTGTATCAAAAGTTCGAGACGATGCTGA

TCAATAAGCTGAATTATCTTGTGTTTAAGGACATTAGCATCACGGAAAATGGAGGGC

TGTTGAAAGGCTATCAACTGACGTATATCCCTGACAAGCTGAAAAATGTTGGCCATC

AGTGCGGGTGCATTTTCTACGTCCCCGCGGCGTATACAAGCAAGATCGATCCTACTA CGGGATTCGTAAATATTTTTAAATTCAAAGACTTAACCGTGGACGCCAAGCGCGAAT

TCATTAAGAAGTTTGATAGCATTCGCTACGATTCAGAAAAAAATCTTTTCTGTTTTA C

GTTCGATTACAACAATTTTATCACCCAGAACACAGTGATGAGCAAGTCATCCTGGTC

TGTCTATACCTACGGTGTCCGTATCAAACGCCGCTTCGTCAACGGACGCTTCTCTAA T

GAATCTGATACCATTGACATCACCAAGGACATGGAAAAGACACTTGAGATGACAGA

TATTAACTGGCGTGACGGACATGACCTGCGTCAGGACATCATCGATTATGAGATTGT

TCAGCATATCTTCGAGATCTTCCGCCTGACAGTACAAATGCGCAATTCACTGTCAGA

ACTTGAAGACCGCGACTATGACCGCCTGATCTCTCCAGTATTAAATGAGAACAATAT

CTTTTATGACAGTGCTAAGGCCGGCGATGCCCTTCCGAAAGATGCTGATGCTAACGG

AGCTTATTGTATTGCATTAAAGGGTCTTTATGAGATCAAGCAAATTACCGAGAATTG

GAAGGAGGATGGCAAATTCTCGCGCGACAAACTGAAAATCAGTAACAAGGACTGGT

TCGATTTTATTCAGAATAAACGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0119] SEQ ID NO: 74

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGAA

CGAACAACTTCCAGAACTTCATCGGCATCAGTTCTTTACAAAAAACCCTGCGTAACG

CCCTTATTCCGACTGAGACAACACAACAGTTCATCGTTAAAAACGGAATTATCAAAG

AGGACGAGTTGCGCGGCGAGAATCGCCAAATTTTGAAAGATATTATGGACGACTAT

TATCGTGGTTTTATTTCAGAAACACTGAGTTCGATTGACGATATCGATTGGACGAGC

CTGTTTGAGAAAATGGAAATCCAGTTGAAAAATGGCGATAATAAAGACACTTTAAT

CAAAGAACAAACCGAGTATCGTAAAGCGATCCATAAAAAGTTCGCTAATGACGATC

GTTTTAAGAATATGTTCAGTGCGAAACTGATTTCAGACATTTTGCCCGAGTTCGTGA

TCCATAATAACAACTATTCCGCCTCGGAAAAGGAAGAAAAAACCCAGGTGATTAAG

CTGTTCAGTCGCTTCGCAACATCTTTCAAGGATTATTTCAAGAATCGCGCGAATTGC T

TCAGTGCGGACGATATTTCTAGTTCAAGCTGCCATCGTATCGTTAATGATAACGCGG

AGATTTTTTTTAGCAATGCTCTGGTGTACCGCCGCATTGTTAAGTCACTGTCCAACG A

TGATATTAACAAGATCTCAGGAGACATGAAAGACTCGCTTAAAGAGATGAGTCTGG

AAGAGATCTATTCTTATGAGAAGTATGGCGAGTTTATTACCCAAGAAGGAATCTCAT

TCTACAATGATATTTGTGGAAAGGTGAACAGCTTTATGAATCTTTACTGCCAAAAAA

ACAAGGAGAATAAGAATCTTTACAAACTTCAGAAGTTACATAAACAGATTTTGTGTA

TTGCGGATACGTCTTATGAAGTCCCCTACAAATTTGAATCGGATGAAGAGGTATACC

AAAGTGTGAACGGATTCTTGGACAATATTTCTTCTAAACATATTGTTGAACGCTTAC

GTAAGATCGGGGATAACTACAATGGCTACAATCTTGACAAAATCTACATTGTTAGCA

AATTCTACGAGAGTGTCAGCCAAAAGACGTACCGCGATTGGGAAACAATTAATACT GCGCTTGAGATTCACTATAATAACATTTTACCAGGCAACGGCAAGTCCAAGGCGGAT

AAAGTTAAAAAAGCTGTTAAAAACGATTTGCAAAAATCTATCACAGAAATTAACGA

GTTAGTTAGTAACTACAAACTGTGCTCCGATGACAACATTAAGGCTGAGACGTATAT

CCATGAGATCTCTCACATCTTAAACAATTTTGAAGCTCAAGAACTTAAGTACAATCC

GGAAATCCACCTGGTGGAATCCGAGCTGAAGGCTAGCGAACTGAAGAACGTATTGG

ACGTGATCATGAACGCGTTCCACTGGTGTTCTGTCTTTATGACGGAAGAGCTTGTCG

ACAAAGATAATAACTTTTACGCGGAACTTGAGGAAATTTACGATGAGATTTACCCAG

TTATTTCATTGTATAACCTTGTCCGTAATTACGTGACCCAAAAGCCTTATAGTACGA A

AAAAATCAAATTAAATTTTGGAATCCCAACACTGGCTGACGGTTGGAGCAAATCTA

AGGAGTATTCTAATAACGCAATCATCTTAATGCGTGACAACCTGTATTATTTGGGTA

TCTTCAATGCCAAAAATAAGCCTGACAAAAAGATTATCGAAGGAAATACTTCGGAG

AATAAGGGGGATTACAAAAAAATGATTTACAATTTGCTGCCCGGGCCGAACAAGAT

GATCCCCAAAGTGTTCTTATCCTCGAAGACTGGTGTAGAAACATACAAGCCAAGCGC

AT AC ATT CTGGAGGGTTAC AAGC AAAAC AAACAC AT CAAATCTTCAAAAGACTTTG

ACATTACATTTTGCCATGATCTTATTGACTACTTCAAAAACTGCATTGCTATTCACC C

CGAGTGGAAGAACTTTGGGTTTGACTTCAGCGACACGTCTACGTATGAGGACATCTC

CGGGTTCTACCGTGAAGTTGAGTTACAAGGGTATAAGATTGACTGGACGTATATTTC

AGAGAAAGATATCGATCTTTTGCAGGAAAAGGGCCAGTTATATTTATTCCAGATTTA

CAACAAGGACTTTAGTAAGAAGTCAACAGGAAATGACAACTTGCATACGATGTATT

TGAAAAATCTTTTTTCTGAGGAAAATCTTAAGGACATCGTACTGAAATTGAATGGCG

AGGCTGAAATCTTCTTCCGTAAATCCTCCATTAAGAATCCCATTATCCACAAAAAGG

GGTCTATCCTGGTGAATCGTACCTACGAGGCAGAGGAGAAGGATCAATTCGGAAAT

ATTCAGATTGTTCGTAAGAACATCCCCGAGAACATTTATCAAGAATTGTATAAGTAC

TTTAATGACAAATCTGACAAAGAGTTATCCGACGAAGCTGCGAAACTGAAAAACGT

TGTTGGTCACCACGAGGCCGCCACTAATATCGTAAAAGACTACCGTTATACCTATGA

CAAGTACTTTTTGCACATGCCGATCACTATCAACTTCAAGGCGAATAAGACGGGCTT

CATTAACGATCGTATCCTGCAATACATCGCCAAGGAGAAGGACCTTCACGTCATTGG

GATTGACCGTGGTGAGCGTAACCTGATTTATGTAAGCGTCATTGATACCTGCGGTAA

TATCGTCGAACAGAAAAGTTTCAACATTGTAAATGGATATGACTATCAGATCAAACT

TAAGCAGCAGGAGGGTGCACGCCAGATTGCCCGCAAGGAATGGAAGGAGATTGGG

AAGATTAAGGAAATTAAAGAAGGTTACTTATCACTGGTTATTCACGAGATCAGTAA

AATGGTAATCAAATATAACGCGATCATTGCCATGGAGGATCTGAGCTATGGCTTTAA

AAAGGGCCGTTTCAAAGTCGAGCGCCAGGTATATCAAAAGTTTGAAACAATGCTGA

TTAACAAATTAAACTATCTGGTTTTCAAAGATATTTCGATCACTGAAAATGGCGGGC

TGTTGAAGGGATACCAACTTACATACATCCCTGACAAACTGAAAAATGTCGGTCACC AATGTGGATGTATCTTTTATGTACCAGCAGCGTATACGAGCAAAATCGATCCAACTA

CGGGTTTTGTGAACATCTTTAAGTTCAAGGATTTGACAGTAGATGCCAAACGCGAGT

TCATTAAAAAATTTGATTCAATTCGCTACGATTCAGAGAAAAATCTTTTTTGTTTCA C

GTTCGATTACAATAATTTCATTACGCAGAACACAGTAATGTCAAAGTCAAGCTGGTC

GGTCTACACGTATGGAGTCCGTATTAAACGTCGTTTTGTAAACGGCCGTTTCTCAAA

TGAATCAGATACAATTGATATTACGAAGGATATGGAGAAGACATTAGAGATGACTG

ACATTAACTGGCGCGACGGACATGATCTTCGTCAGGACATTATTGATTATGAGATTG

TACAGCATATCTTTGAGATCTTCCGCCTGACCGTTCAGATGCGCAATTCGTTGTCCG A

GTTAGAAGACCGCGATTACGACCGTTTAATCAGTCCCGTCTTAAACGAAAATAACAT

CTTCTACGATTCAGCCAAGGCAGGCGATGCCTTGCCAAAGGATGCTGACGCAAATG

GCGCATACTGTATTGCGTTGAAAGGCCTTTATGAAATCAAGCAAATTACCGAAAACT

GGAAAGAAGACGGAAAATTCTCCCGTGATAAGTTGAAAATCTCTAATAAGGATTGG

TTCGATTTCATCCAAAATAAACGCTATTTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0120] SEQ ID NO: 75

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAA

CTAATAATTTCCAAAATTTTATAGGCATCTCTTCTTTACAGAAGACTCTTCGTAACG C

CCTAATCCCGACTGAGACCACACAACAATTCATAGTGAAAAATGGGATCATTAAAG

AAGACGAGCTGCGTGGGGAGAACAGGCAGATCCTAAAAGACATAATGGACGATTAT

TATAGAGGGTTCATCTCAGAGACATTATCTAGCATCGACGACATTGACTGGACCTCC

CTGTTTGAAAAAATGGAAATCCAGCTGAAGAATGGTGACAATAAAGACACATTAAT

AAAAGAACAAACAGAGTACAGGAAAGCCATCCACAAGAAGTTCGCAAACGATGAC

AGATTCAAAAATATGTTCAGTGCGAAGCTAATATCCGACATCTTACCAGAGTTTGTA

ATACACAATAACAATTACAGCGCGAGCGAAAAGGAAGAGAAAACGCAAGTAATTA

AGCTTTTTAGTAGGTTCGCTACCTCTTTCAAAGATTACTTCAAAAATCGTGCTAACT G

CTTCTCAGCCGACGACATATCTTCAAGTTCCTGTCACCGTATCGTGAATGATAACGC

TGAGATATTCTTCTCAAACGCCCTTGTATACCGTAGGATCGTAAAGTCCTTATCTAA C

GATGATATAAACAAGATCAGTGGAGACATGAAAGACAGCCTTAAAGAGATGTCTCT

AGAAGAAATTTACTCCTATGAAAAGTATGGGGAGTTTATAACACAGGAGGGGATCA

GCTTCTACAACGACATCTGCGGAAAGGTGAACAGTTTCATGAATCTTTACTGCCAGA

AGAATAAAGAGAACAAAAATCTTTATAAGCTTCAAAAGTTGCACAAACAAATACTG

TGCATTGCCGATACATCATATGAGGTCCCCTATAAGTTCGAATCTGATGAGGAAGTT

TATCAATCTGTTAACGGCTTTCTAGACAATATCAGCTCAAAACACATCGTAGAAAGA

CTGAGGAAAATAGGTGATAATTATAATGGATACAACTTGGATAAAATATATATAGT CTCTAAATTTTACGAGTCAGTATCCCAGAAAACGTATAGGGATTGGGAGACCATCAA

CACGGCGTTAGAGATTCATTACAATAACATCTTACCGGGAAACGGAAAAAGTAAGG

CGGACAAAGTAAAGAAAGCCGTTAAAAATGACTTACAAAAGAGTATAACAGAAAT

AAACGAACTAGTAAGCAACTACAAGCTTTGTTCCGATGATAATATCAAGGCCGAGA

CATATATCCATGAGATCTCCCACATTCTAAACAATTTCGAAGCGCAAGAACTTAAAT

ATAATCCCGAAATCCACCTGGTGGAAAGTGAACTAAAGGCTAGTGAGTTAAAGAAC

GTTCTTGATGTTATCATGAACGCCTTCCATTGGTGCTCTGTTTTTATGACCGAGGAG T

TGGTTGATAAAGATAATAATTTCTACGCTGAATTAGAGGAGATATACGACGAAATCT

ACCCAGTGATTTCACTATACAACTTGGTCAGGAACTATGTTACACAAAAGCCGTACA

GCACTAAGAAAATTAAGCTAAATTTCGGTATCCCCACGTTAGCCGACGGGTGGAGC

AAGTCCAAAGAATATTCCAACAATGCGATTATTTTAATGCGTGACAATCTTTATTAC

CTTGGCATCTTCAATGCCAAAAACAAACCTGACAAAAAGATTATAGAAGGTAATAC

GTCCGAGAACAAAGGCGATTACAAGAAGATGATTTATAACCTACTGCCCGGACCAA

ACAAAATGATCCCCAAAGTTTTTCTTAGTTCTAAAACCGGCGTAGAGACGTATAAAC

CTTCTGCCTATATCTTAGAGGGATATAAGCAGAACAAACATATCAAATCTTCCAAGG

ACTTTGATATTACATTCTGCCACGATTTAATTGACTACTTCAAAAATTGCATAGCGA T

ACATCCGGAGTGGAAGAACTTTGGCTTCGACTTCAGTGATACATCCACCTATGAGGA

TATATCAGGCTTCTATCGTGAGGTCGAATTGCAAGGGTACAAAATCGATTGGACGTA

TATATCCGAGAAAGACATAGACCTTCTTCAAGAAAAGGGGCAGTTATATTTATTCCA

AATATACAACAAGGACTTCAGTAAGAAGTCAACAGGTAATGACAACTTACACACCA

TGTACTTGAAAAATTTATTTTCTGAAGAAAACCTAAAGGACATTGTACTAAAACTGA

ACGGGGAGGCAGAAATTTTTTTTAGAAAGAGCAGCATAAAAAACCCAATAATTCAT

AAGAAAGGAAGCATTTTAGTTAATAGGACGTACGAGGCAGAGGAAAAGGACCAGTT

TGGCAATATCCAGATCGTAAGGAAAAATATTCCTGAAAACATATATCAGGAACTAT

ATAAATACTTTAACGACAAATCCGACAAAGAATTATCCGACGAGGCTGCAAAGCTG

AAGAACGTCGTAGGGCACCATGAGGCAGCGACTAATATTGTGAAAGACTATAGGTA

TACATACGACAAATACTTTCTGCACATGCCCATCACGATTAACTTCAAGGCGAACAA

GACGGGATTCATTAACGACCGTATATTACAATATATTGCTAAGGAGAAAGATCTGCA

TGTAATAGGTATCGACAGAGGCGAACGTAATTTAATCTACGTGTCCGTCATCGACAC

GTGCGGGAACATCGTAGAGCAAAAGAGTTTTAATATAGTAAATGGCTATGATTACC

AAATTAAGCTAAAGCAGCAAGAAGGAGCAAGACAGATAGCTAGGAAAGAATGGAA

GGAGATAGGAAAAATAAAGGAGATCAAGGAGGGGTATCTTAGCCTAGTAATTCATG

AAATATCTAAGATGGTTATCAAATACAACGCTATCATAGCGATGGAAGACTTATCTT

ATGGTTTCAAGAAAGGAAGGTTCAAAGTAGAGCGTCAAGTTTATCAAAAGTTCGAA

ACGATGTTGATTAATAAACTAAACTATTTGGTATTTAAAGATATATCTATCACCGAG AATGGTGGTCTACTAAAGGGTTACCAGCTTACATACATACCGGACAAACTTAAAAA

CGTCGGACATCAGTGTGGATGCATTTTCTACGTTCCAGCTGCATATACCAGCAAGAT

CGACCCAACGACTGGGTTCGTAAATATTTTTAAATTCAAGGATTTGACTGTCGACGC

CAAAAGAGAGTTCATAAAAAAGTTCGATTCAATTAGGTACGACAGCGAAAAGAATT

TGTTCTGCTTTACTTTTGACTATAACAATTTCATTACTCAGAACACTGTAATGTCTA A

GTCCTCTTGGTCAGTCTATACTTATGGCGTTCGTATCAAACGTAGATTTGTTAACGG T

AGATTCTCAAATGAAAGTGATACAATAGATATCACGAAAGATATGGAGAAAACATT

AGAAATGACAGACATAAACTGGAGAGACGGACATGACTTGAGACAGGACATTATTG

ACTACGAGATCGTGCAGCACATCTTTGAGATCTTTCGTTTGACCGTACAAATGCGTA

ACAGTTTATCTGAGCTTGAGGACAGGGACTACGATAGATTGATATCACCTGTATTAA

ATGAGAATAACATCTTCTATGATTCCGCAAAAGCAGGCGACGCTCTACCCAAAGAC

GCTGATGCGAACGGTGCTTATTGCATAGCTTTAAAGGGTTTGTATGAGATCAAACAG

ATAACAGAAAATTGGAAGGAAGATGGTAAGTTCTCCCGTGACAAGCTTAAAATATC

AAATAAGGACTGGTTCGATTTTATACAGAATAAGCGTTATTAAAACGTCCGGCAGCG

ACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCA

GCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCG

GGCTAA

[0121] SEQ ID NO: 76

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGAA

CTAATAACTTCCAGAATTTCATTGGTATCTCCTCTTTACAAAAAACTCTAAGAAACG

CCCTAATTCCGACTGAAACTACACAGCAATTCATCGTCAAAAACGGGATCATTAAGG

AGGATGAGTTGAGGGGTGAAAATCGTCAAATTCTTAAAGACATCATGGACGACTAC

TACAGGGGGTTCATCAGCGAGACGTTATCTAGTATAGACGATATAGACTGGACTTCA

CTGTTCGAGAAGATGGAAATCCAATTAAAAAATGGGGACAATAAAGATACACTTAT

AAAGGAACAGACAGAGTATAGAAAGGCAATACACAAAAAGTTTGCCAACGACGAT

CGTTTCAAGAACATGTTTAGTGCTAAATTGATTTCAGATATTCTGCCGGAATTTGTT A

TTCACAACAATAATTATAGCGCCAGTGAGAAAGAAGAAAAAACGCAGGTTATCAAA

CTGTTCAGTCGTTTCGCTACATCTTTTAAGGATTACTTTAAAAACCGTGCAAATTGT T

TTTCAGCCGACGATATTAGTAGCAGCTCTTGTCACCGTATTGTTAATGATAATGCGG

AGATTTTCTTTTCAAACGCATTGGTCTACAGGAGGATAGTCAAGTCCCTTTCAAATG

ACGACATTAATAAGATCTCAGGTGACATGAAAGATTCCTTAAAGGAAATGTCCCTG

GAAGAGATCTATTCCTATGAAAAGTACGGTGAGTTCATTACTCAAGAGGGTATAAG

CTTTTACAATGACATATGTGGTAAGGTTAATAGCTTTATGAACCTGTATTGCCAGAA

GAACAAAGAAAATAAGAATCTGTATAAGTTGCAAAAGCTACACAAACAAATTTTGT

GCATTGCCGATACATCATACGAGGTGCCATACAAATTCGAGAGCGATGAGGAGGTT TATCAGAGCGTGAATGGATTCCTGGACAATATTAGTAGTAAGCATATCGTGGAAAG

GCTTAGAAAGATAGGTGACAATTACAATGGCTACAATCTGGATAAAATCTACATCGT

CTCAAAATTCTATGAAAGTGTATCCCAGAAGACGTACCGTGATTGGGAAACTATCAA

CACCGCTCTGGAGATACATTACAACAATATACTTCCCGGAAACGGCAAGTCAAAAG

CCGACAAAGTCAAAAAAGCGGTCAAGAACGATTTACAAAAGTCTATCACTGAAATT

AATGAATTAGTTAGTAATTACAAACTGTGTAGTGATGATAATATTAAGGCAGAGACT

TACATACACGAAATTTCACACATTTTAAACAACTTCGAGGCACAGGAACTTAAATAT

AATCCTGAAATTCACCTGGTTGAAAGTGAATTGAAAGCCAGCGAGCTAAAGAACGT

TTTGGACGTAATCATGAACGCATTCCACTGGTGCTCTGTCTTTATGACAGAGGAACT

AGTGGATAAGGACAATAATTTTTATGCGGAGCTGGAGGAAATATACGATGAGATAT

ATCCCGTAATATCATTATATAATCTGGTAAGAAACTATGTGACTCAAAAGCCGTATA

GCACCAAGAAAATTAAACTTAATTTCGGCATACCCACTTTAGCGGACGGCTGGTCAA

AATCCAAAGAGTATAGTAATAATGCCATCATCCTGATGCGTGACAACCTGTACTATT

TAGGTATATTTAACGCCAAAAATAAACCCGACAAAAAGATTATAGAGGGCAACACC

TCAGAGAACAAAGGTGATTATAAGAAGATGATTTACAACCTTTTACCCGGTCCTAAT

AAGATGATTCCCAAAGTCTTTCTATCTAGCAAAACTGGTGTTGAAACATACAAACCC

TCAGCTTATATTTTAGAAGGGTATAAGCAGAATAAGCATATTAAAAGCTCCAAAGAT

TTCGATATTACCTTTTGCCATGACTTGATAGACTATTTCAAAAATTGTATTGCCATT C

ACCCTGAATGGAAAAACTTCGGATTTGACTTCTCTGACACATCCACCTACGAAGACA

TTTCAGGTTTTTACAGGGAAGTCGAGCTACAGGGTTATAAAATTGATTGGACATACA

TCAGCGAGAAAGATATTGACCTACTTCAAGAAAAAGGGCAGCTATACCTGTTCCAG

ATATACAATAAAGACTTCAGTAAAAAAAGCACCGGGAACGATAATCTTCACACAAT

GTACTTAAAAAATTTATTTAGTGAAGAGAATCTGAAGGATATAGTGCTGAAGTTAAA

CGGGGAGGCAGAGATATTTTTTAGAAAATCTAGTATTAAGAATCCGATCATCCACAA

GAAGGGTTCTATCCTTGTTAATAGGACTTATGAGGCAGAAGAAAAAGACCAATTCG

GCAACATACAAATTGTCCGTAAAAATATCCCTGAGAACATTTATCAGGAACTATACA

AGTACTTCAATGATAAAAGCGACAAGGAGCTGAGCGACGAGGCTGCTAAGTTAAAG

AATGTGGTGGGCCACCATGAGGCAGCAACGAATATTGTGAAGGACTATCGTTATAC

CTACGATAAATACTTTCTTCATATGCCGATCACCATTAATTTCAAGGCAAACAAAAC

TGGCTTCATTAACGATCGTATCTTACAATATATCGCAAAAGAGAAAGACCTTCACGT

TATCGGGATCGATAGAGGCGAGCGTAACCTAATTTATGTTTCTGTGATAGACACCTG

TGGGAACATAGTCGAACAGAAATCATTTAATATTGTTAACGGCTACGATTATCAGAT

AAAGTTGAAGCAACAAGAGGGTGCACGTCAAATAGCAAGGAAAGAATGGAAAGAA

ATAGGCAAGATTAAAGAAATAAAAGAAGGTTATTTATCCCTTGTAATACACGAAAT

TAGCAAAATGGTGATTAAATATAATGCGATCATTGCCATGGAGGATCTTTCTTACGG CTTCAAAAAGGGGAGATTCAAAGTCGAGAGGCAGGTGTATCAGAAGTTTGAGACCA

TGCTAATCAATAAACTAAATTATCTAGTATTCAAAGACATAAGCATCACCGAAAATG

GCGGCTTGTTGAAGGGTTATCAATTGACCTACATCCCAGATAAACTAAAAAACGTAG

GGCATCAATGCGGATGTATATTTTACGTTCCAGCCGCATACACTTCCAAAATCGATC

CAACTACGGGTTTTGTGAACATCTTCAAATTCAAAGACTTGACTGTCGATGCTAAGA

GGGAGTTTATCAAGAAATTTGACTCCATTAGATACGACAGTGAGAAGAATCTGTTCT

GTTTTACCTTTGATTATAACAACTTTATAACTCAAAACACAGTCATGAGTAAGTCAT

CTTGGTCAGTGTATACGTATGGTGTGAGGATTAAAAGGAGGTTTGTTAACGGGAGAT

TTTCCAATGAAAGTGATACAATAGATATAACCAAGGACATGGAAAAGACTCTTGAA

ATGACCGACATTAACTGGAGAGATGGCCACGACTTACGTCAAGATATAATCGATTA

CGAGATAGTGCAACATATCTTTGAGATATTTAGGCTTACTGTCCAAATGCGTAACTC

ATTAAGTGAGTTGGAGGACAGGGATTACGATAGGCTAATAAGTCCTGTTCTTAACGA

AAACAATATATTCTACGATTCAGCAAAGGCGGGAGACGCCCTGCCCAAGGACGCGG

ATGCTAACGGCGCATACTGTATTGCCCTGAAAGGCTTGTACGAGATAAAACAGATC

ACGGAGAACTGGAAAGAAGATGGAAAATTCAGTCGTGACAAGTTAAAAATTAGTAA

CAAAGACTGGTTCGACTTTATTCAGAACAAGAGATATCTGAAACGTCCGGCAGCGA

CCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAG

CCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0122] SEQ ID NO: 77

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAA

CCAATAACTTTCAAAACTTTATAGGCATCTCCAGTCTACAGAAGACACTACGTAACG

CTTTGATACCAACTGAGACCACGCAGCAGTTTATCGTCAAGAACGGTATTATAAAGG

AAGACGA GCTAA GGGGGGAAAACCGTCAGATCTTAAAGGACATCATGGATGACTAC

TACAGAGGCTTCATAAGTGAGACTTTGTCTAGTATAGACGACATCGACTGGACCAGT

TTATTTGAGAAGATGGAAATTCAGTTAAAGAACGGGGACAATAAAGACACACTAAT

TAAAGAGCAGACCGAATACAGAAAAGCTATACACAAAAAGTTTGCCAACGATGATA

GATTCAAAAATATGTTTTCAGCAAAATTGATTTCCGACATATTGCCAGAATTCGTAA

TCCATAATAACAATTATTCTGCAAGTGAGAAGGAAGAGAAGACCCAAGTAATCAAG

CTGTTTTCCCGTTTTGCTACGAGTTTCAAAGATTATTTCAAGAATAGGGCTAATTGT T

TCTCCGCGGACGACATAAGTAGCAGTTCCTGTCACAGGATTGTGAACGATAATGCTG

AGATATTTTTTTCCAATGCCCTAGTGTATAGGAGAATAGTTAAAAGCTTAAGCAACG

ACGATATCAATAAAATTTCAGGGGACATGAAGGACAGCTTAAAGGAAATGAGTTTG

GAGGAGATTTACAGTTATGAAAAATACGGAGAGTTTATAACTCAGGAAGGCATCTC

TTTCTATAATGATATCTGTGGGAAGGTAAACTCCTTCATGAATTTATATTGCCAGAA GAATAAGGAAAACAAAAATCTTTACAAGCTTCAAAAGTTACATAAGCAGATCTTAT

GTATTGCCGACACGAGTTATGAAGTGCCTTATAAATTCGAGAGTGATGAGGAAGTGT

ATCAGTCTGTTAACGGATTCCTAGATAATATAAGTTCCAAACATATAGTCGAGAGGC

TGAGGAAGATTGGCGATAACTATAATGGATATAATCTTGACAAAATCTATATAGTCT

CTAAATTTTATGAAAGCGTCAGCCAGAAGACATATAGAGATTGGGAAACTATAAAC

ACAGCCCTTGAAATACATTACAATAACATCCTACCCGGCAATGGTAAGTCTAAGGCA

GACAAAGTTAAAAAAGCAGTAAAGAATGACTTACAGAAGTCAATCACGGAGATAA

ATGAGTTGGTCAGTAACTACAAATTATGCTCCGACGATAATATTAAGGCCGAAACAT

ATATACACGAGATAAGTCATATATTAAACAATTTCGAAGCCCAGGAGTTAAAATAT

AACCCTGAAATTCATCTGGTCGAAAGTGAGTTAAAGGCCAGTGAGTTAAAGAATGT

ACTTGACGTAATTATGAATGCTTTTCATTGGTGCTCCGTGTTCATGACCGAGGAGTT A

GTAGATAAAGACAATAACTTTTACGCCGAACTTGAAGAGATATACGACGAGATTTA

TCCGGTAATCAGCTTGTACAACTTAGTTAGAAATTATGTAACACAGAAGCCTTACTC

TACTAAAAAAATAAAACTGAACTTTGGTATCCCAACTCTTGCAGATGGTTGGAGTAA

AAGCAAGGAATATAGCAACAATGCGATCATCTTGATGAGAGACAACTTGTACTATTT

GGGAATCTTCAACGCGAAAAATAAACCCGACAAAAAAATCATCGAAGGGAATACCT

CTGAGAATAAAGGTGACTATAAGAAAATGATTTACAATCTACTTCCTGGTCCTAATA

AAATGATCCCGAAAGTGTTTCTTAGTTCTAAGACTGGTGTCGAGACGTACAAACCTA

GCGCGTACATCTTAGAAGGGTACAAGCAGAATAAACACATCAAATCAAGCAAAGAC

TTCGATATTACTTTTTGCCATGACTTGATAGACTACTTTAAAAACTGCATAGCAATC C

ACCCGGAGTGGAAAAACTTTGGCTTTGATTTCTCTGACACCTCTACATATGAGGACA

TATCTGGTTTTTACCGTGAGGTTGAATTGCAGGGATACAAAATTGACTGGACTTACA

TATCTGAAAAAGATATCGATCTATTGCAGGAGAAAGGCCAGCTTTACCTTTTCCAGA

TCTATAATAAGGACTTCTCTAAGAAGTCTACAGGGAATGATAATTTGCACACTATGT

ACTTAAAAAATCTGTTTTCCGAGGAAAACTTGAAAGACATTGTTTTAAAGTTGAACG

GAGAAGCTGAAATATTTTTCAGAAAGAGCTCCATAAAAAACCCGATCATTCATAAG

AAGGGATCTATCCTGGTTAACAGAACGTACGAAGCGGAAGAAAAAGACCAATTCGG

AAACATTCAAATTGTTAGAAAGAATATCCCTGAGAACATCTACCAGGAGTTATATAA

GTATTTTAATGATAAGTCAGATAAGGAACTATCTGACGAAGCGGCGAAGCTTAAAA

ATGTTGTAGGACACCATGAGGCTGCTACAAATATAGTCAAGGACTACCGTTATACCT

ACGATAAGTACTTTCTACACATGCCCATTACCATCAATTTTAAAGCTAATAAAACGG

GTTTTATCAACGATCGTATCCTACAATATATTGCGAAAGAGAAGGATTTGCATGTCA

TTGGCATTGATAGAGGTGAGAGGAACCTAATATACGTATCCGTGATTGATACGTGCG

GGAACATAGTTGAACAGAAATCATTTAATATAGTTAATGGGTACGACTATCAGATTA

AGCTAAAGCAACAAGAAGGCGCCAGGCAAATTGCCCGTAAAGAATGGAAAGAGAT CGGGAAGATCAAGGAAATAAAAGAAGGATACCTTTCCCTGGTCATCCATGAAATTA

GCAAAATGGTGATTAAGTACAATGCCATAATCGCGATGGAGGACTTAAGCTACGGG

TTCAAAAAGGGGAGGTTTAAGGTGGAGAGGCAAGTGTACCAGAAATTTGAGACCAT

GCTAATCAACAAACTGAACTACCTAGTTTTTAAGGACATTTCAATTACAGAGAATGG

AGGACTTTTAAAGGGTTACCAACTAACGTATATACCAGATAAGTTGAAAAATGTCG

GTCACCAGTGTGGCTGCATCTTTTACGTTCCCGCCGCTTATACATCTAAAATTGATC C

AACCACAGGCTTTGTAAATATCTTTAAATTCAAAGATTTAACTGTGGATGCAAAAAG

AGAGTTTATCAAGAAATTCGATAGCATTCGTTATGATAGCGAGAAGAACCTGTTCTG

CTTTACTTTCGACTATAACAACTTTATAACTCAAAACACCGTGATGTCAAAAAGCTC

ATGGTCAGTCTACACCTATGGTGTAAGGATTAAAAGGCGTTTCGTGAATGGGAGATT

CTCCAATGAAAGTGACACGATCGACATAACAAAGGACATGGAGAAGACACTAGAG

ATGACTGATATTAATTGGAGAGACGGACACGATCTGCGTCAAGATATAATTGATTAT

GAGATAGTACAGCACATATTTGAGATCTTCCGTTTGACTGTCCAAATGCGTAATTCC

CTTTCTGAGCTGGAAGATAGGGACTATGATAGATTAATATCCCCTGTACTAAATGAG

AACAACATTTTCTATGATAGTGCAAAAGCCGGGGATGCATTGCCGAAAGACGCTGA

CGCTAATGGGGCGTACTGTATAGCTTTAAAGGGGCTTTACGAAATAAAGCAGATAA

CCGAAAACTGGAAGGAAGATGGCAAATTCTCAAGGGACAAACTTAAGATCTCTAAC

AAGGATTGGTTCGATTTTATACAAAACAAACGTTATTTGAAACGTCCGGCAGCGACC

AAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCC

CGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGG

CTAA

[0123] SEQ ID NO: 78

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGTA

CAAACAACTTTCAGAATTTCATTGGGATCTCTAGCTTACAGAAGACCCTGAGGAATG

CGTTGATTCCAACTGAAACAACCCAGCAATTCATCGTGAAAAATGGGATAATCAAA

GAGGATGAGTTAAGGGGTGAAAACCGTCAAATATTGAAGGATATTATGGACGACTA

CTACCGTGGATTCATCTCAGAGACGTTGAGCAGCATTGACGACATAGACTGGACTAG

CCTTTTCGAGAAGATGGAAATTCAGTTAAAGAACGGAGATAACAAAGATACACTAA

TCAAGGAACAGACAGAATACAGAAAAGCAATTCATAAGAAATTCGCTAATGACGAT

CGTTTTAAAAACATGTTCTCTGCAAAATTAATTAGCGACATTCTGCCGGAATTCGTT

ATACATAATAATAACTACAGTGCTTCTGAAAAGGAAGAGAAAACTCAGGTAATAAA

ACTGTTCTCTCGTTTTGCCACATCCTTCAAAGACTACTTTAAAAATAGAGCGAACTG

CTTTAGCGCCGACGATATTAGTTCTTCCTCATGCCACAGGATTGTCAACGATAATGC

AGAGATATTCTTTTCTAACGCACTAGTCTACAGAAGGATTGTAAAGTCTTTGTCAAA

TGATGACATAAACAAGATTAGTGGAGATATGAAAGACTCTCTAAAGGAAATGAGCC TTGAGGAGATATACTCTTATGAAAAGTACGGTGAGTTTATTACCCAAGAAGGCATTA

GTTTCTATAATGACATTTGTGGAAAAGTTAACAGTTTTATGAATCTATACTGTCAAA

AAAATAAGGAGAATAAAAATCTTTATAAGTTGCAAAAACTGCATAAGCAGATATTA

TGTATAGCAGACACGAGCTATGAGGTACCGTACAAGTTCGAGAGCGATGAGGAAGT

CTACCAATCTGTCAACGGATTTTTGGACAACATTTCTTCAAAACATATTGTGGAGAG

GCTTAGGAAAATAGGCGACAATTATAATGGATATAACTTAGATAAGATATATATTGT

TTCCAAATTCTACGAATCTGTAAGCCAGAAGACATACAGAGATTGGGAAACGATAA

ACACAGCCCTTGAAATTCACTATAACAACATACTACCTGGAAACGGCAAATCAAAG

GCCGACAAAGTTAAGAAGGCCGTAAAGAATGATTTACAGAAGAGCATAACGGAGAT

CAATGAGCTGGTGTCTAACTATAAATTGTGTAGCGATGACAACATAAAAGCCGAGA

CTTACATTCACGAAATTTCACACATACTTAACAACTTTGAAGCTCAGGAATTAAAGT

ATAATCCCGAAATACACCTTGTGGAGTCCGAACTAAAGGCTAGTGAGCTTAAGAAC

GTCCTAGACGTAATTATGAATGCCTTCCACTGGTGTAGTGTTTTTATGACCGAGGAA

CTTGTTGACAAAGATAATAATTTTTATGCAGAACTAGAAGAGATATACGATGAAATA

TACCCGGTGATCAGTTTGTACAATCTTGTCAGGAACTATGTGACACAAAAGCCCTAT

TCAACAAAGAAAATAAAACTTAATTTCGGAATTCCTACGTTAGCTGATGGCTGGTCT

AAATCCAAGGAATACAGCAACAACGCTATAATTCTGATGAGAGATAACTTGTACTA

TCTAGGCATCTTCAATGCCAAAAATAAGCCTGATAAGAAGATTATAGAGGGCAACA

CTTCAGAGAACAAGGGCGACTACAAGAAAATGATCTATAACCTATTGCCTGGCCCA

AACAAGATGATTCCGAAGGTCTTCCTATCATCCAAGACCGGCGTTGAGACATACAA

GCCATCAGCGTATATTTTAGAGGGGTACAAACAAAACAAGCACATAAAGTCTAGTA

AAGACTTCGATATAACATTTTGTCATGACTTAATTGACTACTTTAAGAATTGCATCG C

TATACACCCGGAATGGAAGAATTTCGGCTTCGACTTCTCTGATACATCTACCTACGA

GGACATTAGCGGGTTTTACCGTGAAGTCGAATTACAAGGGTATAAGATAGATTGGA

CGTACATCTCTGAGAAAGACATAGACTTGCTTCAGGAAAAGGGCCAGTTGTATCTAT

TCCAAATATACAATAAGGATTTTTCCAAGAAATCTACGGGTAATGACAATCTTCACA

CAATGTATCTTAAGAACCTTTTCTCAGAAGAGAACCTGAAGGACATTGTCTTAAAAC

TAAATGGCGAAGCTGAGATTTTTTTCAGGAAGTCTTCAATTAAGAACCCGATAATCC

ACAAGAAGGGGAGTATTCTTGTGAATAGAACTTACGAGGCCGAAGAAAAAGACCAA

TTTGGTAACATCCAGATAGTCAGAAAGAACATTCCAGAGAACATCTACCAAGAGCT

ATACAAATATTTCAACGACAAGTCCGATAAGGAACTGTCCGATGAGGCAGCCAAGT

TGAAGAATGTCGTGGGTCATCATGAAGCTGCTACTAACATTGTCAAGGACTATCGTT

ATACTTACGACAAGTATTTCCTACACATGCCGATAACAATTAATTTCAAGGCTAACA

AAACAGGCTTTATCAACGATCGTATCTTGCAGTACATAGCTAAGGAAAAGGATTTGC

ATGTGATTGGCATTGATAGAGGGGAGCGTAACTTGATATATGTGTCTGTCATAGACA CGTGTGGCAACATCGTCGAACAGAAATCATTCAACATAGTAAACGGCTACGATTAC

CAAATTAAGCTGAAACAGCAAGAGGGTGCACGTCAAATTGCGCGTAAAGAGTGGAA

AGAAATTGGTAAAATCAAGGAAATTAAAGAAGGCTACTTGTCTCTTGTTATACATGA

AATTTCCAAGATGGTTATAAAGTATAACGCGATAATTGCTATGGAAGACTTATCATA

CGGGTTTAAAAAGGGGAGGTTCAAGGTAGAGAGGCAGGTCTATCAAAAGTTCGAGA

CGATGTTGATTAATAAACTAAACTATCTAGTGTTCAAAGATATCAGCATTACGGAGA

ACGGGGGGCTACTGAAAGGATATCAACTAACGTACATTCCCGATAAGTTAAAGAAC

GTTGGTCATCAATGTGGTTGCATCTTCTACGTGCCTGCTGCCTATACGTCCAAAATA G

ATCCAACTACTGGATTTGTTAACATCTTTAAATTCAAAGATTTAACCGTAGACGCCA

AAAGGGAATTTATAAAAAAATTTGACAGCATCCGTTACGATAGCGAAAAGAATCTG

TTCTGTTTTACTTTCGACTACAATAATTTCATCACGCAAAATACGGTAATGTCTAAG T

CAAGTTGGAGCGTCTACACGTATGGAGTCAGGATCAAGAGGCGTTTCGTAAATGGA

AGATTCTCTAATGAGTCAGATACTATAGACATCACGAAAGATATGGAGAAAACCTT

GGAGATGACGGATATTAACTGGCGTGATGGACACGATTTAAGACAGGACATTATTG

ACTATGAGATTGTGCAACACATCTTCGAAATATTCCGTCTAACAGTCCAAATGAGGA

ATAGCCTAAGTGAATTGGAGGACCGTGATTACGATAGGCTTATAAGTCCTGTCCTTA

ACGAAAACAATATTTTCTATGATAGTGCTAAGGCGGGGGACGCACTGCCTAAAGAC

GCAGATGCTAACGGGGCATACTGCATTGCGTTAAAGGGTCTGTACGAAATCAAGCA

GATTACGGAAAACTGGAAAGAGGATGGCAAGTTTAGCAGAGATAAGTTGAAGATAA

GTAACAAAGATTGGTTTGACTTTATTCAGAATAAAAGGTATTTAAAACGTCCGGCAG

CGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGG

CAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTC

CGGGCTAA

[0124] SEQ ID NO: 79

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGCA

CTAATAATTTCCAGAATTTCATCGGCATTAGCAGCTTACAAAAGACGTTGAGGAATG

CCTTAATACCCACAGAAACTACTCAACAATTTATAGTGAAGAATGGGATAATTAAG

GAAGACGAGTTGAGAGGTGAAAATAGGCAAATCTTGAAAGACATTATGGATGACTA

CTACAGGGGCTTCATTAGTGAAACGTTGTCTTCAATAGATGACATTGATTGGACTTC

TTTGTTTGAGAAGATGGAAATACAGTTAAAGAACGGCGACAATAAGGATACACTTA

TCAAAGAGCAAACAGAATATAGAAAAGCAATTCACAAAAAGTTTGCTAACGATGAT

AGGTTCAAGAACATGTTTAGCGCTAAACTAATATCAGACATCCTTCCCGAGTTCGTT

ATTCATAACAATAACTATAGTGCAAGTGAAAAAGAGGAGAAGACACAGGTGATTAA

GCTGTTCTCCAGATTCGCGACTTCTTTCAAAGATTACTTCAAAAACAGAGCCAACTG

TTTTTCAGCTGACGATATCTCTAGTAGTAGTTGTCACCGTATAGTGAACGATAACGC TGAGATCTTCTTTAGCAATGCATTAGTGTATAGAAGGATAGTTAAGTCTCTAAGCAA

TGATGATATCAATAAAATTTCCGGAGACATGAAGGACTCCCTAAAGGAAATGTCCTT

AGAAGAGATCTACTCATATGAGAAATACGGGGAATTTATTACGCAGGAAGGGATCT

CCTTTTACAATGACATATGCGGGAAGGTCAACTCTTTCATGAACTTATACTGCCAAA

AGAACAAGGAGAACAAGAATTTATATAAACTTCAGAAACTTCACAAACAAATACTG

TGCATAGCCGATACCTCATATGAGGTTCCTTACAAATTTGAATCAGATGAAGAGGTA

TACCAATCCGTTAACGGCTTTCTTGACAATATTAGCTCAAAGCACATCGTGGAGAGG

TTGAGAAAGATTGGTGATAATTATAATGGCTACAATCTAGATAAGATATATATTGTT

AGCAAGTTCTACGAGTCTGTGTCCCAAAAAACATATAGGGATTGGGAGACAATTAA

TACTGCTCTAGAAATCCATTACAACAACATCCTTCCTGGAAATGGCAAGAGTAAGGC

CGACAAAGTCAAGAAAGCAGTGAAAAATGATCTGCAAAAATCAATTACTGAGATAA

ACGAGCTAGTATCTAATTACAAGCTTTGTAGCGACGATAACATTAAGGCAGAAACG

TACATACACGAGATTAGTCACATCTTAAATAATTTTGAAGCCCAAGAACTGAAATAT

AACCCTGAGATACACCTTGTTGAATCCGAGTTAAAGGCGTCTGAACTAAAAAACGT

GTTAGACGTTATTATGAATGCCTTCCACTGGTGTAGCGTCTTTATGACTGAGGAGTT

GGTTGATAAGGATAATAACTTTTACGCTGAATTGGAAGAAATTTATGACGAAATCTA

TCCTGTTATTTCTCTATATAATTTGGTGAGAAATTACGTAACGCAAAAGCCCTATAG T

ACGAAAAAAATAAAACTAAATTTCGGGATCCCTACCCTAGCCGACGGTTGGTCTAA

ATCCAAGGAGTACTCAAACAATGCAATAATATTGATGAGGGACAACCTGTACTACC

TAGGCATATTTAATGCCAAAAATAAGCCCGATAAAAAGATTATAGAAGGGAACACG

TCAGAAAATAAAGGAGACTATAAGAAAATGATCTACAACCTTTTGCCCGGCCCCAA

TAAAATGATCCCGAAGGTCTTCCTAAGTAGCAAGACTGGCGTAGAGACCTACAAAC

CATCTGCATACATTTTGGAGGGGTACAAGCAAAACAAGCACATAAAGAGTAGTAAG

GATTTTGACATTACATTCTGCCATGACTTAATTGACTACTTTAAAAATTGCATCGCA A

TTCACCCTGAATGGAAAAATTTTGGATTTGATTTCTCTGATACTTCAACATATGAGG

ATATTTCAGGGTTCTACAGGGAGGTCGAACTACAGGGTTACAAAATAGACTGGACG

TATATTTCTGAGAAAGATATAGATTTGCTTCAGGAAAAGGGTCAGCTATATCTGTTC

CAGATATATAATAAGGACTTCTCCAAAAAGAGTACCGGAAATGATAATCTGCACAC

AATGTACTTAAAAAACTTGTTCTCTGAGGAGAATCTAAAAGACATCGTACTAAAACT

TAACGGGGAGGCCGAAATTTTTTTTAGGAAGTCCAGCATCAAGAACCCGATTATTCA

TAAAAAAGGTAGCATTTTGGTGAACCGTACTTATGAGGCGGAAGAAAAAGACCAAT

TCGGTAATATTCAAATCGTTAGAAAGAACATCCCTGAGAACATTTATCAGGAACTAT

ACAAATACTTTAACGACAAATCAGATAAGGAGCTTTCTGATGAGGCAGCTAAATTG

AAAAATGTAGTGGGACATCACGAAGCAGCCACTAACATAGTGAAGGACTACAGATA

CACATACGATAAGTACTTCCTGCACATGCCTATTACAATTAACTTTAAAGCAAATAA AACAGGGTTTATTAACGACAGAATCTTACAGTATATTGCCAAAGAAAAGGATCTGC

ATGTGATAGGAATAGACAGAGGAGAAAGAAACCTGATATACGTCTCCGTGATTGAT

ACATGTGGGAACATAGTAGAACAGAAGTCCTTTAACATTGTTAATGGGTACGATTAT

CAAATTAAATTAAAACAACAAGAAGGAGCACGTCAAATAGCTAGGAAAGAATGGA

AAGAGATAGGAAAAATTAAGGAAATTAAGGAGGGTTACCTGTCCCTTGTAATTCAT

GAAATATCCAAAATGGTAATTAAATATAACGCGATCATCGCGATGGAAGATCTAAG

CTACGGGTTCAAAAAAGGCAGGTTTAAGGTGGAGAGGCAAGTTTACCAAAAGTTCG

AGACAATGTTGATTAATAAGTTAAACTACTTAGTTTTCAAAGATATCTCCATAACCG

AGAATGGCGGGCTTTTAAAAGGGTACCAACTAACATATATCCCGGATAAATTGAAG

AACGTTGGACACCAGTGTGGCTGCATATTTTATGTACCCGCTGCGTATACTTCTAAA

ATTGACCCGACCACCGGGTTTGTAAACATATTCAAGTTTAAGGACCTAACAGTTGAC

GCCAAACGTGAGTTCATCAAGAAGTTCGATAGTATAAGGTATGACTCTGAGAAGAA

CCTTTTCTGCTTCACGTTTGACTATAATAATTTCATCACCCAAAATACAGTTATGTC A

AAAAGCTCTTGGTCAGTATATACGTATGGCGTAAGGATTAAGCGTAGGTTCGTGAAC

GGTAGATTTTCCAACGAGTCAGATACTATTGATATTACCAAGGATATGGAGAAGAC

ATTAGAAATGACAGATATAAATTGGAGGGATGGGCACGATCTAAGGCAAGATATCA

TTGATTACGAAATTGTTCAGCACATATTCGAGATATTCCGTCTTACAGTACAAATGC

GTAACAGCTTGTCTGAGTTGGAAGATCGTGACTATGACAGGTTGATATCACCGGTCT

TGAACGAGAACAATATATTCTACGACAGCGCTAAGGCGGGAGACGCTCTGCCTAAA

GACGCAGATGCCAATGGGGCGTACTGCATTGCCTTAAAAGGCTTATACGAGATTAA

ACAGATCACAGAGAACTGGAAAGAGGACGGCAAGTTTTCTAGAGATAAATTGAAAA

TCTCAAACAAAGACTGGTTCGATTTCATCCAAAACAAAAGATACCTTAAACGTCCGG

CAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGC

AGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTT

ATTCCGGGCTAA

[0125] SEQ ID NO: 80

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGAA

CTAACAACTTCCAGAACTTTATCGGCATCTCTTCCCTCCAAAAGACACTGAGAAATG

CACTGATCCCAACCGAAACGACTCAACAATTTATTGTTAAGAACGGCATCATAAAA

GAAGACGAGCTTCGCGGCGAGAACCGCCAGATACTTAAGGATATTATGGACGATTA

TTACCGAGGCTTTATCAGCGAAACTCTTAGCTCTATTGATGATATCGACTGGACCTC

CCTCTTCGAAAAAATGGAGATACAGCTCAAGAACGGCGATAATAAAGACACCTTGA

TAAAGGAACAGACTGAGTACAGGAAAGCGATCCACAAGAAATTCGCGAACGACGA

CAGGTTTAAAAACATGTTCTCTGCAAAATTGATATCCGACATCTTGCCGGAATTTGT

GATACACAACAATAACTATAGCGCTTCAGAGAAAGAAGAGAAGACCCAAGTAATCA AGTTGTTCAGCCGCTTCGCAACGTCTTTTAAAGATTACTTTAAGAACCGGGCCAATT

GTTTCTCCGCGGATGATATTAGCTCATCAAGTTGCCATCGAATTGTCAATGATAATG

CGGAGATCTTCTTCAGCAATGCGCTGGTCTACAGACGAATCGTAAAAAGTCTTTCAA

ATGACGACATCAATAAGATTAGTGGAGATATGAAGGATTCCCTTAAGGAAATGAGT

CTTGAAGAAATATACTCATACGAAAAGTACGGGGAATTTATTACCCAGGAGGGGAT

CTCCTTCTATAACGACATCTGTGGAAAAGTAAACTCATTCATGAACCTGTACTGTCA

GAAAAACAAAGAAAACAAAAATCTGTATAAACTCCAAAAATTGCACAAGCAAATAT

TGTGTATAGCGGACACATCATACGAGGTTCCATATAAGTTCGAAAGTGATGAAGAA

GTCTACCAATCAGTGAATGGGTTTCTGGACAACATTAGTTCCAAGCACATAGTTGAA

CGACTGCGAAAGATTGGTGACAATTACAACGGCTATAATTTGGACAAGATTTATATA

GTTAGCAAATTTTATGAATCCGTATCACAAAAGACTTATAGAGACTGGGAAACAATC

AACACGGCACTTGAGATCCATTATAACAATATTCTTCCAGGGAACGGCAAAAGCAA

GGCTGATAAGGTAAAAAAGGCCGTTAAGAATGATCTTCAAAAATCCATAACGGAGA

TCAACGAACTTGTAAGTAACTACAAATTGTGCTCTGACGACAATATAAAGGCTGAA

ACGTATATTCACGAGATTAGCCATATCCTGAATAACTTTGAGGCCCAAGAACTCAAG

TATAACCCGGAAATACATTTGGTAGAAAGCGAGCTTAAAGCGAGTGAGCTGAAAAA

CGTCCTCGATGTGATCATGAATGCTTTCCACTGGTGTAGTGTCTTTATGACTGAGGA

GTTGGTTGATAAAGACAATAATTTCTACGCTGAACTGGAAGAAATTTACGACGAAAT

CTATCCAGTGATCTCCCTCTATAACCTCGTTCGAAACTACGTGACGCAGAAACCTTA

TTCTACAAAGAAAATTAAGTTGAACTTCGGCATTCCTACACTTGCTGACGGATGGTC

CAAATCCAAAGAGTACTCAAACAACGCAATCATCCTCATGCGGGATAACCTTTATTA

TTTGGGCATTTTCAACGCCAAAAACAAACCTGATAAAAAGATAATTGAAGGCAATA

CGAGTGAGAACAAGGGCGACTACAAAAAAATGATATATAACTTGTTGCCAGGCCCC

AACAAGATGATTCCTAAAGTTTTTCTGTCTTCTAAGACTGGAGTTGAAACTTACAAA

CCCTCCGCCTACATTCTTGAAGGGTATAAACAGAATAAGCACATAAAGTCCTCAAAG

GATTTCGACATTACGTTTTGCCATGACCTCATCGACTATTTCAAGAACTGTATCGCC A

TACATCCGGAGTGGAAGAATTTTGGATTTGATTTCTCCGACACATCTACCTATGAAG

ACATAAGCGGTTTCTACCGGGAGGTCGAGCTTCAGGGCTATAAGATAGATTGGACA

TACATTAGTGAAAAAGATATCGATCTTCTGCAAGAAAAGGGACAACTTTACCTTTTT

CAGATTTATAATAAAGACTTTTCAAAAAAGTCCACAGGGAACGATAATCTGCACAC

CATGTATCTCAAGAATCTGTTTAGTGAAGAAAACCTTAAAGACATAGTTTTGAAGCT

TAACGGAGAGGCTGAGATTTTTTTTAGAAAGTCCTCAATTAAAAACCCTATAATACA

CAAGAAAGGCTCTATTCTTGTTAACAGGACATATGAAGCCGAGGAGAAAGATCAGT

TTGGCAATATCCAGATTGTTCGCAAGAATATCCCGGAAAATATATATCAGGAGCTGT

ATAAATACTTTAACGACAAGAGCGACAAGGAGCTGAGTGACGAGGCCGCGAAGCTT AAGAATGTAGTAGGTCACCACGAAGCAGCCACCAATATCGTCAAAGACTATAGGTA

CACGTACGACAAGTACTTTTTGCACATGCCTATAACTATAAACTTCAAAGCTAATAA

AACTGGGTTTATTAATGACAGGATTCTCCAATACATCGCTAAAGAGAAGGATCTGCA

TGTAATTGGCATAGACAGAGGTGAGAGAAACTTGATATATGTCAGCGTAATAGACA

CATGTGGCAATATCGTGGAACAGAAGTCTTTTAACATCGTCAATGGTTACGACTACC

AAATTAAGTTGAAACAGCAGGAAGGCGCACGACAGATCGCACGAAAGGAATGGAA

AGAGATAGGCAAAATAAAAGAAATAAAGGAGGGCTATCTCAGTCTCGTTATACACG

AAATTTCAAAAATGGTTATTAAGTACAATGCAATCATAGCGATGGAGGATCTCAGTT

ATGGGTTCAAAAAGGGTCGGTTTAAAGTTGAGCGCCAAGTGTACCAAAAGTTCGAG

ACAATGCTGATTAACAAGCTGAACTACCTCGTCTTCAAAGATATAAGTATTACGGAG

AACGGTGGCCTTCTTAAAGGCTATCAACTTACTTACATCCCGGACAAGCTCAAAAAC

GTAGGGCACCAATGCGGGTGTATTTTCTATGTGCCTGCGGCATATACGTCAAAGATT

GACCCAACCACAGGATTCGTAAACATATTCAAGTTTAAGGACCTCACCGTTGATGCG

AAAAGGGAGTTCATTAAAAAATTTGATTCTATTCGATATGATAGTGAGAAAAATCTC

TTTTGTTTCACATTTGACTATAATAATTTTATTACTCAGAATACTGTCATGAGCAAG T

CATCH GGT C AGT GTAC AC ATACGGGGT GCGGAT C AAACGC AGGTTCGT C AAT GGT C

GCTTCTCAAACGAATCAGACACCATTGACATCACAAAGGACATGGAAAAAACCCTT

GAGATGACCGACATTAATTGGCGCGATGGTCATGATCTGCGGCAAGACATCATAGA

CTACGAAATCGTCCAACACATCTTTGAGATCTTTCGCTTGACGGTCCAAATGCGGAA

CTCCCTGTCCGAGCTCGAGGATAGAGATTATGATCGGCTGATATCTCCCGTGCTTAA

TGAAAATAACATCTTCTACGACTCCGCCAAGGCGGGTGATGCCCTGCCGAAGGATG

CGGATGCTAATGGCGCTTATTGCATTGCTCTTAAGGGGCTCTATGAGATAAAGCAGA

TCACGGAAAACTGGAAAGAAGACGGTAAGTTTAGTAGAGACAAGCTGAAGATCTCA

AATAAAGACTGGTTTGATTTCATACAGAACAAGCGGTACCTGAAACGTCCGGCAGC

GACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGC

AGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCC

GGGCTAA

[0126] SEQ ID NO: 81

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGCA

CTAACAATTTTCAGAATTTCATCGGCATTTCAAGTCTGCAAAAAACTCTGAGGAATG

CTTTGATCCCTACTGAAACCACTCAGCAATTTATAGTCAAGAACGGTATAATTAAAG

AAGATGAACTCAGGGGTGAAAATAGACAAATACTCAAGGACATTATGGATGACTAT

TATAGAGGCTTCATCTCAGAGACTCTCTCATCAATAGATGATATCGATTGGACTAGC

CTTTTCGAGAAAATGGAGATTCAGTTGAAAAATGGTGATAACAAAGATACGTTGAT

AAAGGAACAGACCGAGTACAGGAAAGCCATTCATAAGAAATTTGCTAATGACGATA GATTTAAGAATATGTTTAGTGCAAAACTGATTAGTGACATTCTGCCGGAGTTCGTTA

TCCATAATAATAACTACTCTGCATCCGAAAAGGAGGAAAAGACGCAAGTTATTAAA

CTGTTCAGCCGCTTCGCCACAAGCTTCAAGGACTACTTCAAAAATAGAGCCAACTGC

TTTTCTGCCGACGATATATCATCATCTTCATGCCATCGGATCGTTAACGATAACGCC G

AGATATTCTTCAGCAACGCCCTTGTATATCGAAGAATAGTCAAAAGTCTGAGTAATG

ATGATATTAATAAAATTAGCGGTGATATGAAAGACTCCCTGAAGGAAATGTCACTG

GAGGAAATTTATAGTTACGAAAAGTACGGCGAATTCATTACTCAAGAAGGCATATC

CTTCTATAACGACATTTGCGGAAAGGTCAACTCATTCATGAACCTTTATTGCCAGAA

GAATAAGGAGAATAAAAATCTTTACAAATTGCAAAAACTTCACAAACAAATTCTTT

GCATCGCGGATACGTCCTACGAAGTTCCTTACAAATTTGAATCCGATGAGGAAGTGT

ATCAGAGTGTCAATGGATTTTTGGATAATATCTCTTCAAAACATATTGTGGAGAGAT

TGCGCAAAATAGGTGATAACTACAATGGCTACAACCTGGACAAGATTTATATTGTTA

GCAAGTTCTATGAAAGTGTCAGTCAAAAGACCTACAGAGATTGGGAGACAATCAAC

ACGGCGCTCGAAATACACTACAATAACATCCTCCCCGGCAATGGGAAGAGTAAAGC

CGATAAGGTTAAAAAAGCTGTTAAGAACGACCTCCAGAAATCCATCACGGAAATAA

ACGAGCTGGTTTCCAACTATAAGCTGTGTAGCGATGATAATATTAAGGCTGAGACAT

ATATACATGAGATCAGCCACATTCTCAACAATTTCGAGGCACAGGAACTCAAATAC

AATCCCGAGATTCACTTGGTGGAAAGTGAGTTGAAGGCGTCAGAGCTTAAGAATGT

ACTTGACGTAATAATGAATGCTTTTCATTGGTGCTCCGTGTTCATGACTGAGGAACT

CGTGGATAAGGATAATAACTTTTATGCGGAGTTGGAAGAGATATACGATGAAATAT

ACCCGGTTATCTCACTGTATAATCTGGTCAGAAATTACGTGACCCAAAAGCCTTATA

GTACAAAAAAAATAAAGTTGAACTTCGGTATTCCGACATTGGCAGATGGTTGGTCCA

AAAGCAAAGAATACTCTAATAACGCCATTATATTGATGCGAGACAATTTGTATTACC

TTGGGATCTTTAACGCGAAAAACAAACCGGATAAGAAGATCATCGAAGGTAATACA

TCTGAGAATAAGGGGGATTACAAGAAGATGATTTATAATCTGTTGCCGGGGCCAAA

CAAGATGATTCCGAAGGTCTTTCTGTCATCTAAGACAGGAGTAGAGACCTACAAACC

TTCTGCGTACATTTTGGAAGGCTACAAACAGAACAAGCATATAAAATCTAGCAAGG

ACTTTGATATCACGTTTTGTCATGATCTGATAGATTATTTCAAAAACTGCATCGCTA T

ACATCCTGAGTGGAAGAATTTCGGCTTTGACTTTTCTGACACCAGCACATACGAAGA

CATCTCAGGTTTCTACCGGGAAGTCGAGCTCCAGGGGTACAAGATTGACTGGACATA

TATAAGTGAAAAAGACATCGACCTCCTCCAAGAGAAGGGCCAACTTTACCTGTTCCA

GATCTATAACAAAGACTTTTCTAAAAAGTCCACGGGTAACGACAACTTGCACACTAT

GTATCTGAAAAACTTGTTCTCTGAAGAGAACCTCAAGGACATCGTCCTGAAGCTTAA

CGGGGAGGCGGAGATCTTCTTTAGAAAGTCCTCTATCAAAAATCCCATTATCCATAA

AAAGGGCTCTATACTCGTTAATAGGACATATGAAGCGGAGGAAAAAGATCAATTTG GGAACATCCAGATCGTCCGGAAAAATATACCTGAGAATATCTATCAAGAGCTGTAC

AAGTATTTTAATGATAAGTCAGACAAAGAGCTCAGTGATGAGGCGGCAAAGCTCAA

GAACGTGGTGGGGCATCATGAAGCTGCGACGAACATTGTCAAAGATTATAGATACA

CTTACGATAAATACTTCCTCCACATGCCGATAACGATTAACTTCAAAGCCAATAAGA

CGGGGTTTATAAATGATCGGATCCTTCAGTACATTGCGAAAGAGAAAGACCTCCATG

TGATCGGAATTGACCGAGGAGAAAGGAATCTGATTTACGTGTCCGTGATTGATACTT

GCGGGAATATAGTCGAGCAAAAGAGTTTCAACATAGTCAACGGGTATGACTATCAG

ATAAAGCTCAAACAGCAGGAAGGTGCGAGGCAAATTGCGCGCAAAGAGTGGAAGG

AGATAGGCAAGATTAAAGAAATCAAGGAAGGTTATCTCAGCTTGGTGATCCATGAA

ATATCTAAGATGGTTATAAAGTACAATGCCATAATAGCCATGGAGGATCTTTCCTAC

GGGTTTAAGAAGGGCCGATTTAAAGTGGAGCGACAAGTTTACCAGAAGTTCGAAAC

CATGTTGATTAACAAACTTAACTATTTGGTGTTCAAGGATATAAGTATAACCGAAAA

CGGCGGTTTGCTTAAGGGTTATCAGCTCACGTATATTCCTGATAAACTTAAAAACGT

TGGACACCAGTGTGGATGTATCTTCTACGTGCCAGCCGCTTACACTAGTAAGATAGA

TCCTACCACGGGGTTTGTGAATATTTTTAAGTTTAAAGACTTGACAGTCGACGCCAA

AAGGGAATTTATAAAAAAGTTTGATTCTATCCGCTACGATAGTGAAAAAAATCTCTT

TTGCTTTACTTTCGACTATAACAACTTCATTACGCAGAACACTGTCATGAGTAAGTC C

AGCTGGAGCGTCTACACATATGGCGTCCGAATTAAACGACGATTTGTAAACGGGCG

GTTTTCAAACGAATCTGACACGATAGACATTACCAAGGATATGGAGAAGACACTTG

AGATGACCGACATAAACTGGCGGGACGGTCACGATCTTCGGCAGGACATAATTGAT

TACGAAATCGTCCAGCATATATTCGAAATATTTCGACTTACAGTGCAAATGCGGAAC

AGTCTCTCTGAACTGGAAGATCGCGATTATGACCGGTTGATTTCTCCGGTCCTCAAT

GAAAATAACATATTTTATGATAGTGCTAAGGCAGGTGATGCGTTGCCAAAGGATGC

AGACGCTAATGGTGCCTATTGTATCGCGCTCAAGGGATTGTACGAGATAAAGCAAA

TTACGGAGAACTGGAAGGAGGATGGTAAGTTTAGCCGAGACAAGTTGAAGATTAGC

AATAAAGACTGGTTTGATTTTATCCAAAACAAGAGGTACCTGAAACGTCCGGCAGC

GACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGC

AGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCC

GGGCTAA

[0127] SEQ ID NO: 82

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGAA

CTAATAACTTTCAAAATTTCATAGGTATTTCAAGCTTGCAGAAGACCCTGAGGAATG

CCCTGATTCCAACCGAGACAACGCAGCAGTTCATAGTCAAAAATGGCATTATTAAG

GAAGATGAGCTGCGGGGGGAAAACCGACAGATACTCAAGGATATTATGGACGACTA

TTACCGGGGATTTATCTCAGAAACGCTGAGCAGTATTGATGACATCGATTGGACCAG TCTTTTCGAGAAAATGGAAATTCAACTTAAGAATGGTGACAATAAAGACACTCTCAT

AAAGGAGCAAACTGAATACCGAAAAGCCATACACAAAAAGTTTGCCAACGATGACC

GCTTTAAAAACATGTTTTCAGCTAAGCTCATTAGCGACATTCTCCCCGAGTTTGTGA T

TCATAACAATAACTATAGCGCATCCGAGAAGGAGGAAAAAACCCAAGTTATCAAAT

TGTTCAGTAGATTCGCTACGAGCTTTAAAGATTACTTTAAAAACCGGGCTAACTGCT

TCAGTGCAGACGATATCAGCTCCTCATCCTGTCATCGCATCGTCAATGATAATGCTG

AGATCTTCTTTTCTAATGCACTGGTTTACCGCAGGATAGTTAAGTCTCTTAGTAACG A

CGACATCAACAAGATATCAGGAGATATGAAGGATTCCCTTAAAGAAATGAGTCTCG

AGGAGATATATTCTTATGAAAAATACGGCGAATTTATTACCCAAGAGGGCATTAGTT

TCTATAATGACATATGCGGAAAAGTTAATAGTTTTATGAATCTCTATTGTCAGAAGA

ATAAGGAGAATAAGAACCTCTACAAATTGCAGAAGTTGCACAAGCAAATTCTGTGT

ATCGCGGACACCTCTTACGAGGTCCCATATAAGTTCGAGAGTGATGAAGAAGTATA

CCAGAGCGTTAATGGGTTCCTGGACAACATCTCAAGTAAACACATAGTCGAAAGGC

TCCGAAAGATCGGTGATAACTATAACGGATATAATTTGGATAAAATTTATATAGTTA

GCAAATTTTACGAGAGCGTCAGTCAGAAGACCTACCGGGACTGGGAGACCATAAAC

ACAGCGCTGGAAATACATTATAACAACATACTGCCTGGGAACGGTAAGTCAAAGGC

AGACAAGGTTAAAAAGGCTGTGAAGAATGACCTGCAAAAATCAATTACAGAAATAA

ATGAGTTGGTAAGTAATTACAAACTTTGCAGCGATGATAATATAAAGGCAGAGACG

TACATACATGAAATATCTCATATCCTCAACAATTTCGAAGCCCAAGAACTGAAGTAC

AACCCGGAAATTCATCTTGTAGAGTCTGAGTTGAAGGCCTCCGAATTGAAAAACGTT

CTTGACGTAATTATGAATGCCTTCCACTGGTGCTCAGTATTCATGACGGAAGAGCTC

GTGGATAAAGACAACAATTTTTACGCTGAACTGGAAGAAATATATGACGAGATTTA

CCCCGTAATTTCACTCTACAACTTGGTACGAAATTACGTTACCCAAAAGCCATACTC

AACAAAAAAAATTAAACTGAACTTCGGGATACCCACCCTCGCAGATGGATGGTCAA

AGTCCAAAGAGTACAGTAACAATGCAATTATCCTGATGCGAGACAACCTTTATTACC

TCGGGATTTTCAACGCTAAAAATAAACCTGATAAAAAAATAATTGAGGGTAATACC

TCTGAAAACAAGGGGGATTATAAAAAGATGATATACAATCTGCTGCCTGGCCCGAA

CAAAATGATTCCTAAAGTCTTCTTGTCTTCCAAGACTGGAGTCGAAACCTACAAGCC

AAGTGCTTATATACTCGAAGGGTACAAACAAAATAAGCACATAAAATCCAGCAAGG

ATTTTGATATTACATTCTGCCACGATTTGATTGATTATTTTAAGAACTGTATAGCCA T

CCACCCAGAATGGAAGAATTTTGGTTTTGATTTTAGCGATACCTCAACATATGAGGA

TATCTCTGGCTTTTACCGCGAGGTAGAACTGCAAGGTTATAAGATCGATTGGACTTA

TATTTCTGAAAAGGACATAGATCTCCTGCAAGAGAAAGGGCAACTTTATTTGTTTCA

AATATACAACAAAGATTTTAGTAAGAAGAGTACTGGCAATGATAACCTTCACACTAT

GTATCTGAAGAACCTTTTTTCTGAGGAGAACTTGAAGGACATAGTCCTTAAACTCAA TGGGGAAGCTGAAATATTCTTTCGCAAAAGCTCCATTAAAAACCCGATCATTCATAA

AAAGGGTTCCATCTTGGTAAACCGCACATACGAGGCGGAAGAAAAAGATCAGTTCG

GAAATATCCAGATCGTAAGGAAGAATATCCCCGAAAATATATACCAAGAGCTTTAC

AAATATTTTAACGATAAGTCAGACAAGGAACTGTCAGACGAAGCAGCCAAGTTGAA

GAATGTCGTAGGGCACCACGAAGCAGCTACAAACATAGTTAAAGATTATCGGTACA

CCTACGATAAATATTTCCTGCATATGCCAATAACCATAAACTTCAAAGCCAACAAAA

CAGGGTTCATCAATGACCGAATACTTCAGTATATAGCCAAGGAAAAAGACCTGCAT

GTTATAGGAATAGATAGAGGTGAGCGCAACTTGATATATGTCAGCGTGATAGACAC

CTGCGGAAATATCGTCGAGCAAAAAAGTTTCAACATTGTTAATGGCTACGATTACCA

AATTAAATTGAAGCAGCAAGAGGGGGCTCGGCAAATCGCGCGAAAGGAATGGAAA

GAAATCGGGAAGATTAAAGAAATTAAAGAGGGCTACCTGTCTCTTGTAATTCACGA

AATATCTAAGATGGTCATCAAGTATAATGCCATTATTGCGATGGAAGATCTGTCCTA

CGGATTTAAGAAAGGCAGGTTTAAAGTCGAAAGGCAGGTGTACCAGAAATTCGAGA

CCATGCTGATTAATAAGCTCAACTATCTCGTATTTAAGGATATTTCTATAACTGAAA

ATGGAGGGCTTCTCAAAGGATATCAACTCACATACATACCTGATAAGCTGAAGAAC

GTAGGCCACCAGTGTGGATGCATATTCTATGTACCAGCTGCATACACAAGCAAGATC

GATCCAACTACTGGGTTTGTCAATATCTTCAAATTTAAGGACTTGACGGTCGATGCC

AAACGGGAGTTCATCAAAAAGTTTGATAGTATTCGATATGATAGTGAGAAGAACTT

GTTTTGCTTCACATTTGACTACAACAATTTCATAACGCAAAATACGGTTATGTCTAA

ATCCTCATGGAGCGTCTACACTTACGGAGTGAGGATAAAGCGGCGCTTCGTAAATG

GCAGGTTTAGCAATGAATCCGACACGATTGACATAACCAAGGATATGGAGAAAACC

CTCGAGATGACCGATATAAATTGGCGGGATGGACACGATCTGCGACAAGACATAAT

CGATTATGAAATCGTGCAGCACATATTTGAGATATTCAGGCTTACGGTCCAAATGAG

AAATTCCCTTTCCGAACTTGAAGACCGCGATTACGACCGACTGATAAGCCCCGTTCT

GAACGAAAATAACATCTTCTACGACAGCGCTAAAGCGGGAGACGCGCTGCCGAAAG

ATGCGGACGCAAATGGAGCCTATTGTATCGCCTTGAAAGGGTTGTACGAGATCAAA

CAGATAACCGAGAATTGGAAGGAGGATGGGAAGTTTAGTCGAGACAAACTTAAAAT

AAGCAACAAGGACTGGTTCGACTTTATTCAAAACAAACGATATCTCAAACGTCCGG

CAGCGACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGC

AGGCAGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTT

ATTCCGGGCTAA

[0128] SEQ ID NO: 83

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGTA

CTAACAATTTTCAAAACTTTATCGGCATCTCTTCACTTCAGAAAACTCTTCGGAACG C

CCTTATACCGACGGAGACAACGCAGCAGTTTATAGTTAAAAACGGGATCATTAAAG AAGATGAACTCAGAGGGGAAAACAGGCAAATATTGAAGGACATTATGGACGATTAC

TACCGGGGGTTTATTTCAGAGACCCTTTCATCTATTGATGACATAGATTGGACCTCC C

TTTTCGAGAAAATGGAGATACAATTGAAAAACGGCGACAATAAAGATACACTTATC

AAGGAACAAACTGAGTATCGCAAGGCGATTCACAAGAAGTTTGCGAATGACGATCG

CTTTAAGAATATGTTTTCTGCGAAGCTCATAAGTGACATTCTGCCTGAATTTGTCAT T

CATAACAACAATTATTCTGCTAGCGAAAAAGAGGAAAAAACTCAAGTCATTAAGCT

TTTTAGCAGGTTCGCTACTAGTTTTAAAGACTATTTTAAGAACCGGGCGAATTGCTT T

AGCGCTGACGACATATCATCCTCATCCTGTCATCGCATAGTCAATGATAATGCAGAA

ATATTCTTTTCTAATGCGCTCGTGTATCGGAGAATAGTGAAAAGCCTCTCTAACGAT

GACATTAACAAAATAAGCGGCGATATGAAGGATAGTCTGAAGGAAATGTCCCTCGA

AGAAATATACTCATACGAGAAGTACGGAGAATTTATCACCCAGGAAGGAATTAGTT

TTTACAACGACATCTGTGGTAAGGTTAACTCTTTTATGAATCTGTATTGTCAAAAGA

ATAAAGAAAATAAAAATCTTTATAAGCTCCAAAAGCTTCACAAACAAATCTTGTGC

ATTGCGGATACGTCATACGAAGTACCTTACAAATTTGAAAGCGACGAAGAGGTGTA

TCAGTCAGTGAATGGGTTCCTTGACAATATTTCTAGCAAACATATTGTGGAGCGACT

TCGAAAGATCGGTGATAATTACAATGGCTATAATTTGGATAAAATTTACATAGTTAG

TAAGTTTTATGAATCCGTCTCACAAAAGACGTACCGAGATTGGGAGACCATCAACAC

TGCTCTGGAGATTCATTACAATAATATATTGCCTGGGAATGGGAAGTCAAAGGCCGA

CAAGGTTAAAAAAGCCGTAAAAAACGATCTTCAAAAGTCCATTACCGAGATAAATG

AACTTGTATCCAACTATAAGTTGTGCTCTGACGATAATATTAAAGCAGAAACGTATA

TCCACGAAATAAGTCACATCCTGAACAACTTCGAAGCTCAAGAGCTCAAGTATAATC

CTGAAATTCATCTCGTCGAAAGCGAGCTGAAAGCATCCGAGTTGAAGAATGTGCTTG

ATGTGATCATGAACGCATTCCATTGGTGCAGTGTGTTCATGACCGAAGAACTTGTAG

ACAAAGACAACAACTTCTACGCTGAATTGGAAGAGATTTACGATGAAATTTACCCC

GTGATATCCCTCTATAATCTGGTAAGAAATTACGTCACGCAAAAACCATACAGTACC

AAGAAAATAAAGCTCAACTTTGGTATTCCGACGTTGGCAGATGGGTGGAGTAAGAG

CAAGGAGTATTCTAACAATGCAATCATCCTCATGCGCGACAATTTGTATTATCTGGG

GATCTTCAACGCGAAAAATAAGCCCGACAAAAAGATAATAGAAGGCAATACGTCCG

AGAACAAAGGGGACTATAAGAAAATGATTTATAACCTTCTTCCAGGACCCAACAAG

ATGATCCCAAAGGTTTTCTTGAGTTCAAAAACCGGCGTAGAAACTTATAAACCGTCC

GCCTACATTCTGGAAGGGTACAAGCAAAACAAGCACATTAAGTCATCTAAGGATTT

CGACATTACTTTTTGTCATGATTTGATAGACTACTTCAAAAATTGTATAGCGATACA T

CCGGAATGGAAAAATTTTGGGTTCGATTTTTCCGACACAAGTACTTATGAAGACATC

TCAGGGTTTTATAGGGAAGTTGAACTGCAAGGTTACAAAATAGACTGGACTTATATT

AGTGAGAAGGACATTGATTTGCTCCAGGAAAAGGGTCAATTGTATCTGTTCCAGATA TATAACAAGGATTTCTCTAAAAAATCTACAGGTAACGACAATCTCCACACGATGTAC

CTCAAGAATCTCTTCAGCGAAGAGAATTTGAAGGATATCGTACTTAAGCTCAATGGA

GAAGCGGAAATATTCTTCAGAAAGTCCAGCATTAAGAATCCTATAATTCACAAGAA

AGGGTCAATTCTCGTAAACCGGACTTATGAGGCCGAAGAAAAAGATCAGTTTGGTA

ACATTCAGATTGTACGGAAAAACATTCCCGAGAACATCTATCAAGAACTGTATAAAT

ACTTTAATGATAAATCCGACAAGGAACTTTCTGACGAGGCTGCAAAATTGAAGAAC

GTAGTGGGACACCATGAGGCCGCAACCAATATAGTAAAGGATTACAGATACACTTA

TGATAAGTATTTCCTCCATATGCCGATCACGATTAATTTCAAGGCGAATAAAACCGG

CTTCATTAACGATCGCATTTTGCAATATATTGCGAAGGAAAAGGATTTGCACGTGAT

AGGTATAGACCGGGGTGAACGAAACTTGATTTACGTCTCTGTGATCGACACATGCGG

AAATATAGTTGAACAGAAGTCCTTTAATATTGTGAATGGTTACGACTACCAGATAAA

ATTGAAGCAACAGGAGGGCGCAAGACAGATAGCTCGCAAAGAGTGGAAGGAAATC

GGCAAGATCAAAGAAATAAAGGAGGGTTATCTTTCCCTGGTAATTCATGAAATTAG

CAAGATGGTTATTAAGTATAATGCTATAATAGCTATGGAGGACCTTTCCTATGGGTT

CAAGAAAGGTCGCTTC AAAGT GGAGCGAC AAGT GTATCAAA AGTTCGAGACTATGT

TGATAAATAAATTGAATTATTTGGTTTTTAAAGACATTTCAATAACTGAGAACGGGG

GTCTCTTGAAGGGGTACCAATTGACTTATATTCCGGACAAGTTGAAGAATGTCGGAC

ACCAGTGTGGTTGCATTTTCTACGTGCCTGCCGCTTACACCTCAAAAATCGATCCGA

CCACTGGTTTTGTAAATATATTTAAATTCAAAGATCTCACCGTTGATGCCAAACGGG

AGTTTATCAAAAAATTCGATTCCATTCGCTACGACTCTGAGAAAAACCTTTTTTGTT T

CACGTTCGATTATAACAACTTTATAACCCAAAATACTGTAATGTCCAAGTCAAGTTG

GTCTGTCTATACTTACGGAGTAAGGATCAAGCGCCGCTTCGTTAATGGGAGATTCTC

AAACGAGTCTGATACCATAGACATAACTAAAGACATGGAAAAAACCCTGGAAATGA

CGGACATCAATTGGCGAGACGGGCATGATCTTCGACAGGACATAATAGATTACGAA

ATTGTTCAACACATTTTCGAGATATTTCGACTTACGGTTCAGATGAGGAATTCCCTT T

CCGAATTGGAAGACCGGGATTATGATCGACTTATATCTCCCGTGCTCAATGAAAACA

ATATTTTTTATGATTCAGCGAAAGCTGGGGACGCGCTGCCAAAAGATGCCGATGCCA

ATGGAGCATACTGTATCGCCCTGAAGGGTTTGTATGAGATTAAGCAAATTACTGAAA

ACTGGAAGGAAGATGGCAAGTTTTCTAGAGATAAGCTTAAGATTAGCAATAAGGAC

TGGTTTGACTTCATTCAAAATAAAAGGTATCTTAAACGTCCGGCAGCGACCAAAAAA

GCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAA

AGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0129] SEQ ID NO: 84

AGCCCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGAA

CAAATAATTTTCAAAATTTTATTGGTATCAGTTCATTGCAAAAGACTTTGAGAAATG CTTTGATCCCGACTGAGACCACACAGCAGTTCATCGTCAAAAATGGCATAATCAAGG

AAGACGAACTTAGGGGTGAGAATAGACAAATATTGAAGGACATCATGGATGACTAT

TATAGGGGGTTCATTTCCGAAACGCTCAGTAGTATTGATGACATTGACTGGACTAGT

CTTTTCGAGAAAATGGAAATTCAGCTTAAGAACGGGGACAATAAAGACACGCTGAT

CAAGGAGCAAACGGAATATAGGAAGGCGATCCATAAAAAATTCGCGAATGATGATC

GGTTTAAAAACATGTTTAGTGCCAAGTTGATCAGCGACATACTGCCCGAATTCGTGA

TCCACAACAATAATTACAGCGCCTCCGAAAAGGAGGAAAAAACTCAGGTCATTAAA

TTGTTTAGCCGATTCGCAACGAGTTTCAAAGATTATTTTAAGAACCGGGCCAACTGT

TTTTCAGCGGATGATATTAGCTCCAGCAGCTGCCATCGCATAGTAAATGATAACGCT

GAAATCTTTTTTAGCAACGCACTTGTCTACCGGAGGATTGTAAAATCACTGTCAAAT

GATGACATTAACAAAATATCTGGAGATATGAAGGACTCACTCAAAGAAATGAGCCT

GGAAGAAATATATTCATACGAAAAATACGGGGAGTTTATTACCCAGGAAGGTATCA

GTTTTTATAATGATATATGTGGAAAAGTTAATTCATTTATGAATCTTTACTGTCAAA A

AAATAAGGAGAACAAGAATTTGTACAAGCTCCAAAAACTTCATAAACAGATTCTGT

GCATCGCAGACACAAGTTATGAGGTACCGTACAAATTTGAGAGCGACGAAGAAGTT

TATCAGAGTGTGAATGGTTTCCTGGACAATATCTCTTCTAAACACATTGTTGAGAGG

CTTAGGAAGATCGGTGATAATTATAACGGCTATAATCTGGACAAAATTTATATTGTA

TCAAAGTTTTATGAATCAGTCTCTCAAAAGACGTATCGGGATTGGGAAACAATTAAC

ACGGCTCTGGAGATCCACTACAATAACATTCTGCCCGGCAACGGGAAGAGCAAAGC

TGATAAGGTCAAGAAGGCAGTCAAGAACGACCTTCAGAAGAGCATAACAGAAATTA

ACGAATTGGTCAGTAACTACAAACTGTGTAGTGATGACAACATAAAAGCCGAAACA

TACATCCATGAAATAAGCCATATCCTGAATAACTTCGAAGCCCAAGAACTTAAATAC

AATCCCGAGATTCATCTTGTCGAATCAGAACTCAAGGCGTCCGAGCTCAAAAATGTC

CTTGACGTGATAATGAATGCCTTCCACTGGTGCAGCGTATTCATGACGGAGGAGTTG

GTAGATAAAGACAACAACTTTTATGCCGAATTGGAAGAGATTTATGATGAGATTTAC

CCCGTTATTTCTCTGTACAACTTGGTTCGAAACTACGTAACACAAAAACCATACTCA

ACCAAAAAGATCAAACTCAATTTTGGCATACCTACATTGGCTGATGGTTGGTCCAAG

TCAAAGGAATATAGCAATAATGCAATAATTCTCATGCGAGATAACTTGTATTATTTG

GGGATCTTTAACGCTAAGAACAAACCAGATAAAAAGATAATCGAGGGGAACACAA

GTGAGAACAAGGGTGATTACAAAAAAATGATTTACAATCTGCTTCCTGGGCCTAAC

AAAATGATTCCGAAGGTGTTTCTTAGCTCTAAAACTGGAGTGGAGACGTATAAGCCT

TCCGCGTACATTCTCGAAGGCTACAAGCAAAATAAGCATATCAAGTCCAGTAAGGA

CTTCGACATCACTTTTTGCCACGATCTCATCGATTACTTTAAGAACTGTATCGCAAT A

CACCCCGAGTGGAAAAACTTTGGTTTTGATTTTTCAGACACTAGTACCTACGAGGAC

ATTTCCGGCTTCTATCGAGAAGTCGAACTCCAGGGCTACAAAATCGATTGGACGTAC ATTTCTGAGAAGGACATCGACTTGCTCCAAGAGAAAGGTCAACTTTACCTCTTCCAA

ATTTACAATAAAGACTTTTCAAAGAAGAGCACCGGTAATGACAACTTGCATACCATG

TATCTGAAGAACCTGTTTTCTGAGGAGAACCTCAAGGATATTGTATTGAAGTTGAAT

GGCGAAGCAGAAATATTTTTCCGAAAGTCATCTATCAAGAACCCCATTATACACAAA

AAAGGCTCTATCCTGGTGAACCGGACTTACGAGGCAGAGGAGAAGGATCAATTCGG

AAACATACAGATAGTCCGCAAAAACATCCCTGAGAATATCTATCAGGAACTCTATA

AGTACTTCAATGATAAATCAGACAAGGAGCTTAGCGACGAAGCAGCTAAACTTAAA

AACGTGGTTGGCCATCACGAGGCCGCTACCAACATAGTCAAAGACTACCGCTATACT

TATGACAAGTACTTTTTGCACATGCCCATAACAATTAATTTCAAAGCTAACAAAACA

GGGTTTATAAATGACAGAATCCTCCAATACATCGCCAAAGAGAAGGACCTCCATGT

AATCGGGATTGATAGAGGCGAACGGAACTTGATTTACGTTAGTGTCATTGATACCTG

TGGTAACATTGTCGAACAAAAGTCATTCAACATAGTCAATGGATATGATTATCAGAT

AAAACTCAAGCAACAAGAAGGCGCGAGGCAGATTGCCAGGAAGGAATGGAAAGAA

ATCGGGAAGATCAAGGAGATCAAGGAGGGTTACCTGTCCTTGGTGATACACGAGAT

TTCAAAAATGGTTATAAAATACAATGCCATTATCGCGATGGAGGATTTGTCTTATGG

ATTTAAGAAGGGGAGGTTCAAAGTCGAACGACAAGTCTATCAGAAGTTTGAAACAA

TGCTCATTAACAAGCTCAATTACCTTGTTTTCAAGGATATAAGCATCACTGAAAACG

GCGGACTCCTTAAGGGATATCAGCTGACTTATATCCCCGACAAGCTCAAGAACGTAG

GGCACCAATGCGGATGCATCTTTTACGTGCCTGCAGCATATACTTCAAAAATTGATC

CGACTACTGGCTTTGTTAACATTTTCAAGTTCAAGGATCTGACGGTAGACGCTAAGA

GAGAATTCATAAAAAAGTTTGACAGCATCAGGTACGATAGTGAAAAGAACCTTTTTT

GTTTTACCTTTGACTACAATAATTTTATTACGCAAAATACAGTTATGAGCAAATCAA

GTTGGAGCGTTTACACATATGGCGTTCGGATCAAGCGCAGATTCGTCAATGGTCGCT

TCTCAAATGAGAGCGATACAATCGATATAACGAAGGATATGGAGAAGACGCTTGAG

ATGACAGATATCAACTGGCGGGACGGACATGACCTTAGACAAGACATAATCGATTA

CGAAATAGTACAGCATATCTTTGAGATTTTTAGGCTTACAGTTCAGATGCGGAACTC

TCTTTCCGAACTGGAGGACCGGGATTATGATCGGTTGATCTCCCCAGTACTGAACGA

AAATAATATCTTTTACGATAGCGCGAAGGCTGGTGATGCACTCCCAAAAGACGCTG

ATGCGAACGGAGCTTATTGCATAGCCCTTAAAGGGCTTTACGAGATTAAACAAATA

ACAGAAAATTGGAAGGAAGATGGCAAATTTTCCCGCGACAAGTTGAAGATTAGTAA

CAAAGACTGGTTCGACTTCATTCAGAATAAACGCTACCTCAAACGTCCGGCAGCGAC

CAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGC

CCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0130] SEQ ID NO: 85 CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGTACCAA

TAACTTCCAGAACTTCATCGGTATTTCTAGCCTGCAAAAGACCCTGCGTAACGCGCT

GATTCCGACCGAGACTACCCAGCAATTCATCGTGAAAAACGGTATCATTAAGGAAG

ATGAATTGCGCGGTGAGAATCGTCAGATTCTGAAAGATATCATGGATGACTACTATC

GCGGTTTCATTAGCGAAACCCTGTCGAGCATCGATGATATCGATTGGACGAGCCTCT

TCGAGAAAATGGAAATTCAACTGAAAAATGGTGACAACAAAGATACCCTGATTAAA

GAACAAACGGAATACCGCAAGGCAATCCATAAAAAGTTTGCGAATGACGACCGTTT

TAAGAATATGTTCTCGGCCAAGCTGATTTCCGACATCCTGCCAGAGTTCGTCATTCA

CAACAACAATTACAGCGCAAGCGAGAAAGAGGAAAAGACTCAGGTCATTAAGCTGT

TTAGCCGCTTTGCGACGTCCTTCAAAGACTACTTCAAGAATCGTGCGAATTGCTTTA

GCGCGGATGACATCTCTAGCTCTAGCTGTCACCGTATTGTTAACGACAATGCAGAGA

TTTTCTTCAGCAACGCCCTGGTGTATCGCCGTATTGTCAAGTCTCTGAGCAACGACG

ACATTAACAAGATCAGCGGCGACATGAAAGACAGCCTGAAAGAAATGTCTCTGGAA

GAAATCTACAGCTACGAGAAATATGGTGAGTTTATCACCCAAGAGGGCATTAGCTTC

TACAATGATATCTGTGGTAAGGTTAATAGCTTTATGAATCTGTACTGCCAGAAGAAT

AAAGAAAACAAGAACTTGTACAAGCTGCAAAAGCTGCATAAGCAAATTCTGTGCAT

CGCCGATACTAGCTATGAAGTTCCGTACAAGTTCGAGTCTGATGAAGAGGTGTATCA

GTCAGTCAACGGTTTTCTGGATAACATCAGCAGCAAGCACATCGTCGAGCGCCTGCG

CAAGATTGGTGACAACTACAATGGTTATAACCTGGACAAGATCTATATCGTGTCGAA

GTTTTACGAGAGCGTGTCCCAGAAAACGTACCGTGATTGGGAAACGATTAACACGG

CCTTGGAAATTCACTATAACAATATCCTGCCGGGCAACGGCAAGAGCAAAGCTGAC

AAAGTC AAA AAAGCT GT GAAAAACGATCTGC AAAAGTCC ATC ACCGAGAT CAACGA

ACTGGTTAGCAACTATAAGCTGTGTAGCGACGACAACATTAAAGCTGAAACGTATA

TCCACGAAATCAGCCACATCCTGAATAACTTTGAGGCACAAGAACTGAAATACAAT

CCTGAGATCCATCTGGTAGAGAGCGAGCTGAAGGCAAGCGAGTTGAAAAACGTTCT

CGACGTTATCATGAATGCTTTCCACTGGTGTAGCGTGTTTATGACCGAAGAACTGGT

TGACAAAGATAACAATTTCTATGCAGAGCTGGAAGAAATCTATGATGAAATCTACC

CGGTCATCAGCCTGTATAACCTGGTTCGTAACTACGTGACGCAGAAGCCGTACAGCA

CCAAAAAGATCAAGCTGAACTTCGGTATTCCGACCTTGGCGGACGGTTGGAGCAAA

TCCAAAGAATACTCCAATAATGCGATTATTCTGATGCGTGATAATCTGTACTATCTG

GGTATCTTCAATGCGAAGAACAAGCCAGATAAAAAGATTATTGAAGGCAACACCAG

CGAGAATAAAGGCGACTACAAGAAAATGATCTACAACTTATTGCCGGGTCCGAACA

AGATGATCCCGAAAGTTTTTCTGAGCAGCAAGACCGGCGTTGAAACCTATAAGCCG

AGCGCGTACATTTTAGAGGGCTATAAACAAAACAAGCACATCAAGAGCAGCAAAGA

TTTTGATATTACGTTCTGCCACGACCTGATCGACTATTTCAAGAATTGTATTGCGAT T CACCCTGAGTGGAAGAACTTCGGTTTTGACTTTTCCGATACCTCCACCTATGAAGAT

ATTAGCGGTTTTTACCGTGAAGTCGAGTTGCAGGGTTATAAGATTGATTGGACTTAC

ATTTCCGAGAAAGACATCGACCTGTTGCAAGAGAAAGGTCAGCTGTACCTGTTTCAG

ATCTATAACAAAGATTTCAGCAAAAAGTCGACGGGCAATGATAATCTGCACACCAT

GTATCTGAAAAACCTGTTTAGCGAAGAGAACCTGAAAGACATTGTTCTTAAGCTGAA

TGGTGAGGCCGAGATCTTCTTCCGTAAAAGCTCCATTAAGAACCCGATTATCCACAA

AAAGGGCTCTATTCTGGTTAACCGCACGTACGAAGCGGAAGAGAAAGATCAATTTG

GTAACATCCAGATCGTGCGTAAGAATATCCCGGAGAACATTTACCAAGAACTGTAT

AAGTATTTCAATGACAAGAGCGATAAAGAATTGAGCGATGAAGCGGCAAAGCTGAA

AAACGTCGTTGGCCACCACGAAGCCGCGACGAATATCGTGAAAGATTATCGTTACA

CCTACGACAAGTACTTTCTGCACATGCCGATCACCATCAATTTCAAAGCGAATAAAA

CGGGTTTTATCAATGACCGTATCCTGCAGTACATTGCGAAAGAAAAAGATTTACACG

TGATTGGTATTGATCGCGGCGAGCGCAATCTGATTTACGTCAGCGTTATCGACACGT

GCGGCAATATTGTGGAGCAGAAAAGCTTCAATATCGTCAATGGTTACGACTACCAG

ATCAAACTGAAGCAACAAGAGGGCGCCCGCCAGATTGCGCGTAAAGAGTGGAAAG

AAATCGGTAAGATTAAAGAAATCAAGGAAGGCTACCTGTCCCTGGTGATCCATGAA

ATCAGCAAAATGGTGATCAAGTACAACGCTATCATTGCGATGGAAGATCTGAGCTA

CGGTTTTAAAAAGGGTCGCTTCAAAGTTGAGCGTCAAGTGTATCAGAAATTTGAGAC

TATGCTGATTAACAAGTTGAACTATCTGGTTTTTAAAGACATCAGCATTACCGAGAA

TGGTGGCCTGCTGAAGGGTTATCAACTGACCTATATTCCTGACAAGTTGAAAAATGT

TGGTCATCAGTGTGGTTGCATTTTCTACGTACCGGCAGCGTACACGAGCAAGATTGA

CCCGACCACGGGTTTCGTTAACATTTTCAAGTTTAAAGATTTGACCGTGGACGCCAA

GCGTGAGTTCATTAAAAAGTTCGACAGCATCAGATACGACTCTGAGAAGAATCTGTT

CTGCTTTACGTTCGACTACAATAACTTCATTACCCAAAATACCGTTATGAGCAAAAG

CTCCTGGAGCGTGTACACGTACGGCGTCCGTATCAAGCGTCGTTTTGTGAATGGTCG

CTTTTCCAACGAATCTGACACCATTGACATTACCAAAGATATGGAAAAGACCCTTGA

GATGACCGACATTAATTGGCGTGATGGCCATGACTTGCGCCAAGACATTATCGACTA

CGAAATTGTTCAGCACATCTTTGAGATTTTTCGTCTGACGGTCCAGATGCGCAACTC

GCTGAGCGAGTTGGAAGATCGTGACTATGACCGTCTGATTAGCCCGGTGCTGAATGA

AAACAATATCTTCTATGATAGCGCAAAGGCCGGTGACGCGCTGCCGAAAGATGCGG

ATGCTAACGGTGCATACTGCATTGCACTGAAGGGTCTGTACGAAATCAAACAGATC

ACCGAGAATTGGAAAGAGGATGGTAAGTTTAGCCGTGATAAGCTGAAGATTAGCAA

TAAAGACTGGTTCGACTTTATTCAAAACAAGCGCTATCTGAAACGTCCGGCAGCGAC

CAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGC CCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0131] SEQ ID NO: 86

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAACAA

ATAATTTTCAGAACTTTATTGGGATCAGTTCGCTTCAGAAAACGCTTCGTAATGCTC T

GATTCCCACAGAAACCACTCAGCAGTTTATCGTAAAGAATGGCATTATCAAGGAGG

ATGAATTACGCGGCGAGAACCGCCAAATCTTAAAAGATATCATGGACGACTACTAC

CGCGGTTTCATTAGCGAAACTCTTAGTTCAATTGACGACATTGACTGGACGTCCTTG

TTCGAAAAGATGGAGATTCAATTAAAGAACGGTGATAACAAGGATACGTTGATTAA

AGAACAGACGGAGTACCGTAAGGCTATCCACAAAAAATTTGCAAACGACGACCGCT

TTAAAAATATGTTTAGCGCAAAATTAATCTCCGACATCCTGCCTGAATTCGTCATCC

ATAACAATAACTATAGCGCCTCGGAAAAAGAAGAAAAAACGCAGGTTATTAAACTT

TTCTCGCGCTTTGCAACAAGCTTTAAGGATTACTTCAAAAATCGCGCCAATTGTTTT T

CAGCCGACGACATTAGCTCCAGTTCCTGCCACCGTATTGTGAATGACAACGCTGAGA

_{TTTTTTTTTCCAATGCGCTGGTTTATCGTCGTATTGTTAAGAGCCTTAGTAACGA CGA}

CATTAATAAAATTAGCGGTGATATGAAGGATAGCTTGAAAGAAATGAGTCTGGAAG

AGATCTATAGTTACGAGAAGTACGGCGAATTTATTACCCAGGAGGGCATTTCATTTT

ACAATGATATCTGTGGAAAAGTCAACTCCTTTATGAACTTGTATTGCCAAAAGAATA

AAGAAAACAAAAACCTGTACAAACTGCAAAAGTTACACAAGCAGATTTTGTGTATC

GCAGACACGTCATACGAAGTACCGTACAAGTTTGAGTCCGATGAAGAAGTGTACCA

AAGCGTTAATGGCTTTTTGGATAACATTTCGAGCAAACATATCGTAGAGCGTTTGCG

TAAGATTGGTGATAATTACAACGGTTACAATTTAGACAAAATCTATATCGTCTCTAA

GTTTTACGAAAGTGTTTCTCAGAAAACTTACCGCGATTGGGAGACGATCAACACTGC

GCTGGAGATTCATTACAATAATATCCTTCCAGGTAACGGTAAAAGCAAAGCTGATA

AGGTGAAAAAGGCGGTTAAAAATGACCTTCAAAAGTCTATCACAGAAATCAACGAA

TTGGTCAGCAATTATAAGCTTTGCAGTGACGATAACATTAAGGCCGAGACTTACATC

CATGAGATCTCTCACATTCTTAATAATTTTGAAGCGCAAGAGCTGAAATACAATCCT

GAAATCCATCTGGTCGAAAGTGAATTAAAAGCCTCCGAATTAAAAAATGTCTTGGA

CGTGATCATGAATGCGTTCCATTGGTGCTCAGTTTTTATGACGGAAGAGTTGGTGGA

CAAAGACAACAATTTTTACGCCGAGCTTGAGGAAATTTACGACGAAATTTACCCCGT

TATTTCGTTATACAACCTTGTGCGTAATTACGTTACACAAAAGCCCTATTCGACAAA

GAAAATCAAGTTAAATTTCGGGATTCCCACATTAGCTGATGGATGGTCCAAATCCAA

AGAATACTCGAATAACGCTATCATCCTTATGCGTGATAATTTGTACTACTTAGGCAT

CTTCAATGCGAAGAACAAACCTGACAAGAAAATTATCGAAGGAAACACTTCGGAGA

ACAAAGGTGATTATAAAAAGATGATCTACAACTTGCTTCCCGGGCCAAACAAAATG ATTCCCAAGGTATTTTTGAGTTCTAAAACCGGTGTCGAAACTTACAAACCAAGTGCT

TATATTTTGGAAGGATACAAACAGAACAAACATATCAAGTCTTCGAAAGACTTCGAT

ATTACGTTCTGCCACGATCTGATCGATTACTTCAAGAACTGTATTGCTATTCACCCC G

AGTGGAAGAACTTTGGATTTGATTTCTCCGACACGTCCACTTATGAAGATATCTCTG

GCTTCTATCGCGAGGTTGAATTACAAGGGTATAAGATTGACTGGACTTATATTTCGG

AGAAGGATATCGATCTTTTGCAAGAAAAAGGGCAACTTTATTTATTTCAGATCTATA

ACAAGGACTTTTCAAAAAAGAGCACTGGAAATGACAATCTGCATACCATGTACCTT

AAGAACCTGTTCTCGGAAGAGAACCTGAAGGACATTGTACTTAAACTGAATGGAGA

GGCAGAGATCTTCTTTCGCAAATCAAGCATTAAGAACCCAATTATTCACAAAAAGG

GGAGTATCTTAGTAAATCGCACATATGAGGCTGAGGAAAAAGATCAGTTTGGTAAC

ATTCAGATCGTGCGTAAGAACATTCCTGAAAATATCTATCAGGAACTTTATAAGTAT

TTCAACGATAAAAGTGATAAAGAGCTGAGTGACGAAGCGGCTAAACTTAAGAATGT

TGTGGGACACCATGAGGCAGCAACCAATATTGTGAAGGATTATCGCTATACGTACG

ACAAATACTTTTTACACATGCCCATCACTATTAATTTTAAAGCTAATAAGACTGGCT T

CATTAACGATCGCATCCTGCAGTACATTGCTAAGGAAAAGGATCTTCACGTTATCGG

TATCGATCGCGGGGAGCGTAATCTTATCTACGTCTCTGTCATTGACACGTGTGGCAA

TATTGTGGAGCAAAAGTCCTTCAATATTGTTAACGGCTATGACTATCAGATTAAATT

GAAACAGCAGGAAGGTGCGCGTCAGATTGCCCGCAAGGAATGGAAGGAAATTGGC

AAGATCAAAGAAATTAAGGAGGGCTACTTAAGCTTAGTAATTCACGAAATTAGTAA

AATGGTTATCAAATACAACGCCATCATCGCGATGGAGGATCTTTCGTACGGGTTTAA

GAAAGGTCGTTTTAAAGTGGAGCGTCAGGTGTACCAGAAATTTGAAACTATGCTTAT

TAACAAACTTAACTACCTGGTTTTCAAGGATATCAGTATTACTGAAAACGGGGGGCT

GTTAAAAGGGTATCAATTAACTTACATTCCAGACAAATTAAAGAACGTTGGACATCA

GTGTGGCTGCATTTTTTATGTACCAGCTGCATACACTTCAAAGATCGATCCTACGAC T

GGGTTCGTGAACATTTTTAAGTTTAAAGACTTGACGGTAGATGCCAAGCGCGAATTC

ATCAAGAAATTCGACAGCATTCGCTACGACTCTGAGAAAAATCTTTTCTGTTTCACA

TTCGATTATAACAATTTCATTACGCAGAACACAGTAATGTCCAAGTCTTCTTGGAGT

GTTTATACATATGGTGTCCGCATTAAGCGCCGTTTCGTCAACGGCCGCTTCAGTAAT

GAGAGCGATACTATTGACATCACAAAAGACATGGAAAAAACACTGGAAATGACCGA

CATCAATTGGCGTGACGGCCATGACTTACGTCAGGATATCATTGATTATGAGATCGT

TCAACACATCTTCGAAATCTTTCGCTTGACTGTTCAAATGCGCAATTCCTTGTCGGA A

TTGGAGGACCGTGATTATGACCGCTTAATTTCCCCCGTCTTAAATGAAAACAATATT

TTTTATGACTCTGCAAAAGCTGGAGATGCTCTGCCGAAAGACGCCGATGCAAATGG

GGCATATTGCATTGCTTTAAAGGGGCTTTACGAGATCAAGCAAATCACCGAAAACTG

GAAAGAGGATGGAAAGTTTTCGCGTGATAAACTGAAGATCTCTAACAAAGACTGGT TCGACTTTATCCAGAACAAGCGTTATTTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0132] SEQ ID NO: 87

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGCACCA

ATAACTTCCAAAACTTCATCGGGATCTCTAGCCTTCAGAAGACGCTTCGCAATGCTC

TTATCCCAACTGAGACCACTCAACAATTTATTGTGAAGAATGGAATTATTAAAGAGG

ACGAACTGCGTGGCGAGAATCGTCAGATCTTAAAGGACATTATGGATGATTATTACC

GTGGATTCATCTCCGAAACATTATCGTCGATCGATGATATCGATTGGACTTCTCTGT T

CGAGAAAATGGAAATTCAATTGAAAAACGGAGATAATAAAGATACGCTTATCAAAG

AACAGACGGAATATCGTAAAGCGATTCATAAGAAATTCGCAAATGACGATCGTTTC

AAAAATATGTTCAGTGCCAAGCTTATTTCGGACATTTTACCTGAATTTGTAATTCAT A

ATAATAACTACTCAGCAAGTGAGAAGGAGGAGAAAACCCAAGTTATTAAACTGTTC

TCTCGTTTCGCAACGTCCTTTAAAGATTACTTTAAAAACCGCGCGAATTGCTTTAGC G

CTGACGACATTTCCAGCTCATCCTGTCATCGCATCGTAAACGACAATGCGGAAATCT

TCTTCAGCAACGCCCTGGTTTACCGCCGCATCGTCAAAAGCTTATCGAATGACGACA

TCAATAAGATCTCAGGAGATATGAAGGACTCGCTTAAGGAGATGTCTCTGGAGGAA

ATTTATAGTTACGAAAAGTATGGAGAGTTCATTACCCAGGAGGGAATCTCGTTCTAC

AATGACATTTGCGGGAAGGTGAACTCCTTCATGAACTTATACTGCCAGAAAAACAA

AGAGAACAAAAATCTGTATAAATTGCAGAAATTACATAAACAGATTCTTTGTATTGC

TGACACTTCCTACGAAGTACCCTATAAATTCGAGTCAGATGAAGAAGTATACCAGTC

CGTGAACGGATTTCTGGACAATATCTCCTCAAAACACATCGTGGAACGCTTACGTAA

AATTGGCGATAATTATAATGGTTACAATCTTGACAAAATTTATATCGTATCTAAATT T

TACGAGAGTGTGAGCCAAAAGACCTACCGCGACTGGGAGACCATCAACACAGCTTT

AGAAATTCACTATAATAATATCTTACCCGGCAATGGTAAGAGCAAGGCTGACAAGG

TAAAAAAGGCCGTCAAGAATGATTTGCAGAAATCTATTACAGAAATTAATGAGTTA

GTCTCCAACTATAAGCTTTGTTCCGACGATAACATCAAAGCTGAGACATATATTCAT

GAGATTAGTCACATTCTTAACAACTTCGAGGCCCAGGAACTTAAGTACAATCCTGAA

ATTCATCTTGTCGAGTCTGAGCTGAAAGCTAGTGAATTGAAAAATGTTTTAGACGTT

ATTATGAACGCATTCCACTGGTGCTCTGTGTTTATGACAGAAGAACTGGTCGACAAG

GACAATAACTTCTATGCCGAACTTGAGGAAATCTACGATGAAATTTACCCTGTAATC

TCCTTGTATAATCTTGTACGTAATTACGTCACTCAAAAACCTTACAGCACGAAAAAA

ATTAAATTGAACTTCGGGATTCCTACACTTGCCGACGGGTGGTCTAAATCCAAGGAA

TATAGCAACAATGCCATTATTTTAATGCGCGACAATCTTTACTATTTAGGAATTTTT A

ACGCTAAGAACAAGCCCGATAAAAAGATTATTGAAGGAAACACGTCTGAAAATAAG GGCGACTACAAAAAGATGATTTATAACCTTTTGCCCGGTCCAAACAAAATGATCCCA

AAGGTATTCCTGTCATCCAAAACAGGGGTTGAGACATATAAGCCCAGCGCATATATT

CTGGAAGGATACAAACAGAATAAACATATCAAAAGCAGCAAAGATTTTGACATTAC

TTTTTGCCACGATTTAATCGACTACTTCAAAAACTGTATCGCTATCCACCCTGAATG G

AAGAATTTCGGATTTGATTTCTCAGATACAAGTACGTATGAGGATATCAGCGGTTTC

TATCGCGAAGTTGAACTTCAAGGGTATAAAATTGACTGGACCTACATTAGTGAGAA

GGACATCGACCTGTTACAGGAAAAAGGCCAATTGTACTTGTTTCAGATCTACAATAA

GGATTTCTCAAAAAAATCGACCGGCAATGATAACTTGCACACCATGTACCTGAAGA

ACCTTTTTTCGGAGGAAAACCTTAAAGACATTGTCCTGAAGTTGAATGGAGAAGCGG

AGATTTTCTTTCGTAAGTCTTCCATTAAAAATCCAATTATTCATAAGAAGGGCAGCA

TCCTTGTGAACCGTACGTACGAGGCGGAAGAGAAGGACCAATTCGGTAACATTCAA

ATCGTCCGCAAGAACATCCCTGAAAATATTTATCAGGAGCTTTACAAGTATTTCAAT

GATAAGTCCGACAAGGAATTATCAGATGAGGCTGCGAAGTTGAAAAATGTTGTTGG

TCATCACGAGGCGGCGACGAATATTGTAAAGGATTATCGCTACACTTATGACAAGTA

CTTTCTGCACATGCCGATCACCATTAATTTCAAGGCGAACAAAACAGGATTTATTAA

TGACCGCATCTTACAATACATTGCCAAAGAAAAGGACTTACACGTTATTGGCATTGA

TCGTGGAGAACGCAACTTAATCTACGTAAGCGTTATTGACACTTGCGGGAATATCGT

AGAACAAAAGAGCTTCAACATCGTGAATGGTTACGATTACCAGATCAAGCTTAAGC

AGCAGGAGGGAGCGCGCCAGATCGCGCGCAAGGAATGGAAGGAGATTGGTAAGAT

CAAGGAAATCAAGGAAGGTTATCTGTCCTTGGTAATCCACGAAATTTCGAAAATGGT

TATCAAATACAATGCTATTATTGCAATGGAGGACTTGTCCTACGGCTTTAAAAAAGG

ACGCTTTAAGGTGGAGCGCCAGGTTTATCAAAAGTTTGAAACAATGCTGATTAACAA

GCTGAACTATTTGGTCTTTAAAGATATCTCCATCACCGAAAATGGTGGGCTTTTGAA

AGGCTATCAACTTACATATATCCCTGATAAGCTTAAGAATGTGGGTCATCAGTGCGG

GTGCATTTTTTATGTTCCTGCAGCCTACACGTCCAAAATCGATCCTACAACTGGATT T

GTTAATATCTTCAAATTTAAGGATCTTACCGTCGACGCGAAGCGCGAATTTATCAAG

AAATTCGATAGTATTCGTTATGATTCCGAAAAAAACCTTTTCTGTTTCACCTTTGAT T

ATAATAACTTTATCACGCAAAATACTGTCATGAGCAAATCGAGTTGGTCTGTGTACA

CTTACGGAGTACGCATCAAGCGTCGTTTTGTTAATGGGCGCTTCAGTAACGAGTCAG

ACACGATTGATATCACAAAAGATATGGAGAAAACGCTGGAGATGACAGACATCAAT

TGGCGCGATGGTCATGACTTACGTCAAGACATTATCGATTATGAAATTGTCCAGCAT

ATCTTTGAGATCTTTCGTTTGACTGTTCAGATGCGCAACAGCCTGTCAGAATTGGAG

GATCGTGACTATGATCGCCTTATTTCTCCCGTCTTAAATGAGAACAATATCTTCTAC G

ACTCAGCCAAGGCTGGAGATGCACTGCCAAAAGACGCCGACGCAAATGGGGCCTAC

TGTATTGCATTGAAGGGGTTGTACGAGATCAAACAGATTACAGAAAATTGGAAGGA GGACGGTAAGTTCTCTCGTGATAAGCTGAAGATTTCTAACAAAGACTGGTTCGATTT

CATTCAGAACAAACGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCCGGCCAGG

CGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAAACGTAA

AGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0133] SEQ ID NO: 88

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGTACCA

ATAACTTTCAGAATTTCATTGGAATCAGCAGCTTACAGAAAACCCTGCGCAATGCAC

TTATCCCCACTGAGACAACCCAGCAGTTCATTGTAAAGAACGGGATTATTAAAGAA

GATGAGCTTCGCGGGGAGAATCGTCAGATCTTAAAGGATATTATGGACGATTACTAC

CGTGGCTTCATTTCGGAGACGCTGTCGTCGATCGACGACATCGACTGGACATCCTTG

TTTGAAAAGATGGAAATCCAACTGAAGAATGGCGATAACAAGGACACGTTAATCAA

AGAGCAGACGGAATACCGTAAAGCTATCCACAAAAAGTTCGCTAATGACGACCGCT

TTAAGAACATGTTCTCAGCAAAACTTATTAGCGATATTTTACCTGAATTTGTCATCC A

CAATAACAATTACTCCGCGAGTGAAAAAGAGGAGAAAACCCAGGTGATTAAGCTGT

TTTCCCGTTTTGCAACCAGTTTCAAGGACTATTTTAAGAATCGTGCTAATTGTTTCT C

TGCAGACGACATTTCCTCGTCGTCCTGCCATCGCATTGTTAATGATAATGCTGAAAT

_{CTTTTTTTCAAACGCACTTGTGTATCGTCGCATTGTCAAAAGCTTAAGTAATGAC GAT}

ATCAATAAGATCTCAGGAGACATGAAGGACTCCCTGAAAGAAATGTCATTGGAAGA

AATTTACTCTTATGAAAAGTATGGAGAATTTATTACGCAGGAGGGTATCAGCTTCTA

TAACGACATTTGTGGTAAAGTGAACAGCTTTATGAATCTTTATTGTCAAAAGAATAA

AGAGAACAAAAATCTGTACAAGCTGCAGAAATTGCATAAACAAATTCTGTGCATTG

CAGATACTTCGTATGAGGTTCCTTACAAATTCGAGTCGGATGAGGAGGTGTATCAAA

GCGTAAACGGATTTTTGGATAACATTAGTAGTAAGCATATTGTGGAACGCCTTCGCA

AGATTGGTGACAACTATAACGGATACAACTTAGACAAGATCTATATTGTCTCGAAGT

TTTACGAAAGTGTTTCCCAAAAGACTTATCGCGACTGGGAGACAATCAACACTGCGC

TGGAAATTCACTATAACAATATCTTGCCGGGGAACGGAAAAAGTAAGGCAGATAAG

GTGAAGAAAGCAGTCAAAAATGATCTGCAAAAAAGCATTACTGAAATTAACGAACT

TGTGTCAAATTACAAATTGTGTTCGGATGACAATATTAAAGCGGAAACGTATATCCA

CGAGATCTCGCACATTCTTAATAATTTCGAGGCGCAGGAATTAAAGTATAATCCTGA

GATCCATTTGGTGGAATCAGAACTTAAAGCTAGTGAACTGAAAAATGTCCTGGACGT

TATTATGAATGCATTTCACTGGTGTTCTGTCTTTATGACAGAAGAACTTGTCGACAA

AGACAACAACTTTTATGCGGAATTAGAAGAGATTTACGACGAAATTTATCCCGTTAT

TTCGTTATATAATTTAGTTCGTAATTACGTGACTCAGAAACCCTACAGCACAAAAAA

GATTAAATTAAACTTTGGGATTCCGACTCTTGCTGATGGATGGAGCAAGTCCAAGGA

GTACTCTAATAACGCCATTATCTTGATGCGTGACAACCTGTACTACCTGGGCATTTT T AACGCTAAAAACAAACCCGACAAAAAGATCATTGAAGGGAACACCTCGGAAAATA

AGGGGGACTATAAAAAAATGATCTACAATCTGTTGCCAGGCCCAAATAAGATGATC

CCAAAGGTTTTTTTATCTTCCAAAACTGGCGTAGAAACTTACAAGCCGAGCGCATAC

ATCCTTGAAGGATATAAACAAAACAAACATATCAAAAGTTCAAAGGACTTCGATAT

TACGTTCTGCCATGATTTAATCGATTATTTCAAGAATTGCATCGCGATTCACCCAGA

GTGGAAAAACTTTGGGTTTGATTTTTCAGACACCAGCACTTACGAGGATATTAGTGG

ATTCTATCGTGAGGTTGAACTGCAGGGCTATAAAATTGACTGGACCTATATTTCTGA

AAAAGATATTGATCTGCTTCAGGAGAAAGGCCAATTGTACTTATTTCAAATCTATAA

CAAGGATTTCTCCAAGAAGTCCACGGGTAATGACAACTTACACACAATGTATCTGAA

GAATCTGTTTAGTGAGGAGAACTTGAAGGACATTGTGCTGAAGCTTAATGGCGAGG

CCGAAATCTTTTTTCGTAAGTCCTCCATTAAAAACCCTATTATCCATAAGAAAGGGA

GTATTCTTGTCAACCGCACGTATGAGGCCGAAGAAAAGGACCAATTCGGAAACATC

CAAATTGTCCGTAAAAATATTCCTGAGAACATTTACCAGGAGCTTTACAAGTATTTC

AACGACAAGAGTGATAAAGAACTTTCAGATGAGGCGGCGAAACTGAAGAATGTAGT

GGGGCACCACGAAGCTGCCACGAATATTGTAAAGGATTACCGTTACACCTACGACA

AGTACTTTTTGCATATGCCCATCACAATTAATTTTAAGGCCAATAAAACTGGTTTTA T

CAACGATCGTATCTTACAGTACATTGCTAAGGAAAAAGATCTGCACGTTATCGGTAT

CGATCGCGGGGAACGCAATCTGATTTATGTTAGTGTGATTGACACGTGCGGAAATAT

TGTTGAGCAGAAGAGCTTTAATATCGTAAATGGATATGACTATCAAATTAAACTGAA

GCAACAGGAAGGGGCCCGCCAGATTGCCCGCAAGGAGTGGAAAGAAATTGGAAAG

ATCAAGGAGATTAAAGAAGGGTACCTTTCCCTTGTTATCCACGAAATCTCGAAAATG

GTGATCAAGTACAATGCCATTATTGCTATGGAGGATCTGTCATATGGGTTTAAGAAA

GGCCGCTTTAAGGTGGAACGTCAGGTTTACCAGAAGTTTGAGACCATGCTTATCAAT

AAGCTGAATTATCTTGTCTTCAAAGACATCTCAATCACAGAGAACGGCGGGCTGTTA

AAAGGATATCAGCTGACCTATATCCCCGACAAACTGAAAAATGTCGGGCACCAATG

CGGCTGTATTTTCTACGTGCCCGCTGCATACACATCTAAAATTGACCCAACGACTGG

ATTCGTAAATATTTTTAAGTTTAAGGATCTTACGGTAGATGCAAAGCGCGAATTTAT

CAAGAAATTTGATAGTATCCGTTACGACAGCGAGAAAAACTTATTTTGTTTTACGTT

CGATTATAACAACTTCATCACGCAAAATACCGTCATGTCAAAATCTTCCTGGTCAGT

CTATACGTATGGCGTCCGTATCAAGCGCCGCTTCGTCAACGGGCGTTTTTCAAACGA

GTCAGATACCATCGATATCACCAAAGATATGGAAAAAACATTGGAGATGACGGACA

TCAATTGGCGCGATGGTCATGACTTACGCCAGGACATTATTGACTACGAAATCGTAC

AACATATTTTTGAGATTTTCCGTCTGACCGTGCAAATGCGCAACTCATTATCCGAAC T

TGAGGATCGTGATTACGACCGCTTGATCAGTCCTGTTCTGAACGAGAATAATATTTT

TTACGACAGTGCCAAGGCGGGAGACGCACTGCCCAAGGACGCTGACGCTAACGGAG CTTATTGTATTGCGTTGAAGGGACTTTACGAAATCAAGCAAATCACTGAAAACTGGA

AGGAGGATGGTAAATTCTCACGCGACAAGTTGAAAATTTCGAACAAGGACTGGTTC

GATTTCATCCAAAACAAGCGTTATTTAAAACGTCCGGCAGCGACCAAAAAAGCCGG

CCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAAA

CGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0134] SEQ ID NO: 89

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGGACTA

ATAACTTCCAGAACTTCATCGGTATTTCATCATTACAAAAAACGCTTCGTAACGCCT

TGATCCCAACAGAAACGACCCAACAATTTATTGTAAAAAACGGCATCATCAAAGAA

GACGAACTGCGTGGCGAAAATCGCCAAATTTTGAAGGACATTATGGATGACTATTAT

CGTGGGTTTATCTCGGAGACATTATCCTCCATCGACGACATTGATTGGACGAGTCTT

TTTGAGAAAATGGAGATCCAGCTTAAAAATGGTGATAACAAGGATACATTGATCAA

GGAGCAAACCGAGTACCGCAAGGCCATCCATAAGAAGTTCGCAAATGACGACCGCT

TCAAAAATATGTTTAGTGCCAAATTGATCTCGGATATCCTTCCTGAGTTCGTAATTC A

CAACAATAATTATAGCGCATCCGAAAAGGAGGAAAAGACTCAAGTCATTAAGCTTT

TCAGTCGCTTTGCTACCTCGTTTAAGGACTATTTCAAGAACCGCGCGAACTGCTTCT C

AGCGGATGACATTTCTTCCTCGTCGTGTCACCGCATCGTGAATGATAATGCGGAGAT

CTTCTTTAGTAATGCCTTGGTATACCGCCGCATTGTTAAATCCCTGTCTAACGACGA T

ATCAATAAGATCTCAGGAGATATGAAGGATAGCCTTAAAGAAATGTCTCTGGAAGA

AATTTACTCCTATGAAAAGTACGGTGAGTTTATCACCCAAGAGGGGATTAGCTTTTA

TAACGATATCTGCGGGAAGGTGAATTCGTTTATGAACCTTTATTGTCAAAAGAATAA

GGAGAATAAGAACTTATATAAGCTTCAGAAACTGCATAAACAAATCTTATGCATTGC

CGATACTAGCTATGAAGTTCCGTATAAATTCGAGAGCGATGAAGAAGTTTATCAGA

GCGTCAATGGGTTCTTGGATAACATTTCATCAAAACACATCGTGGAACGTCTGCGTA

AGATTGGGGATAACTACAACGGATATAATCTTGACAAAATTTATATTGTATCTAAAT

TCTATGAGTCGGTGAGTCAAAAGACCTACCGTGATTGGGAAACAATCAATACCGCG

TTAGAAATCCACTATAACAACATTCTGCCAGGGAATGGTAAAAGTAAAGCGGACAA

AGTCAAGAAGGCTGTGAAGAACGATCTGCAAAAGAGTATTACAGAGATTAACGAAT

TAGTCTCCAATTATAAGTTATGCTCGGACGATAACATTAAGGCGGAGACGTATATTC

ATGAGATTTCGCATATTCTTAACAACTTCGAGGCACAAGAGCTTAAGTATAACCCAG

AGATTCACCTTGTCGAATCGGAGCTGAAGGCATCGGAATTAAAAAATGTCTTAGATG

TAATCATGAACGCGTTCCATTGGTGCAGTGTTTTCATGACTGAGGAGTTAGTTGACA

AGGACAATAACTTCTACGCAGAATTAGAAGAGATCTATGATGAGATTTATCCAGTG

ATTTCGCTGTATAATCTGGTACGTAATTACGTCACTCAAAAGCCCTACTCAACAAAA

AAAATTAAGCTGAACTTCGGAATTCCGACTCTGGCCGACGGGTGGTCCAAGTCAAA GGAGTATTCTAATAATGCTATCATCCTGATGCGCGATAACTTATACTATTTGGGAAT

TTTCAATGCCAAAAATAAACCAGATAAAAAGATTATCGAAGGTAATACAAGCGAGA

ATAAGGGTGACTATAAGAAAATGATTTACAATCTTCTTCCAGGCCCTAACAAGATGA

TTCCCAAAGTTTTTTTGTCCAGTAAAACAGGGGTCGAAACTTACAAGCCCAGTGCCT

ATATCCTTGAAGGGTACAAGCAGAATAAGCACATCAAATCCTCGAAAGACTTTGAT

ATTACATTTTGTCATGACTTAATCGATTATTTTAAGAACTGTATCGCAATCCATCCA G

AATGGAAGAACTTCGGGTTTGATTTCTCTGATACTTCCACGTATGAGGATATTTCCG

GGTTCTACCGCGAAGTAGAGCTTCAGGGCTATAAAATTGACTGGACATATATTTCAG

AAAAAGACATCGATCTGTTACAAGAAAAAGGACAGTTGTATCTGTTTCAAATCTATA

ATAAGGATTTCTCCAAAAAGTCAACTGGAAATGATAACTTACATACAATGTATCTGA

AAAATCTTTTTAGTGAAGAGAATTTGAAGGATATCGTGCTGAAGTTAAATGGCGAA

GCAGAGATCTTCTTCCGCAAGTCCTCGATCAAGAATCCTATCATCCACAAGAAAGGT

AGTATTCTGGTTAACCGCACGTACGAGGCCGAGGAAAAAGACCAGTTCGGTAATAT

CCAGATTGTACGTAAGAATATTCCTGAAAATATTTACCAGGAATTATACAAGTATTT

TAACGACAAATCGGATAAGGAGCTTTCAGATGAGGCCGCAAAGTTGAAGAACGTCG

TAGGACACCATGAGGCCGCTACGAATATCGTCAAGGACTACCGCTATACGTATGAC

AAGTACTTCCTGCACATGCCTATTACTATCAATTTCAAAGCTAATAAAACAGGATTC

ATCAATGATCGTATCCTTCAGTACATTGCCAAAGAAAAAGATCTGCACGTAATCGGA

ATCGACCGTGGCGAACGTAATCTGATTTACGTATCAGTTATCGACACATGTGGTAAC

ATCGTGGAGCAGAAATCTTTTAACATTGTTAACGGCTATGATTATCAGATTAAGCTT

AAACAGCAGGAGGGGGCACGCCAAATCGCTCGTAAAGAATGGAAGGAGATTGGAA

AGATTAAAGAGATTAAAGAGGGGTACCTTTCGCTGGTTATTCACGAAATTTCCAAGA

TGGTGATTAAGTACAATGCAATCATCGCGATGGAAGATCTTAGTTACGGATTCAAAA

AGGGACGCTTCAAAGTTGAGCGTCAGGTCTACCAGAAATTTGAAACGATGCTGATT

AACAAATTGAATTACTTGGTATTCAAAGATATCTCAATTACTGAAAATGGTGGCTTA

TTAAAGGGTTACCAGCTTACCTATATCCCGGATAAGCTGAAGAACGTGGGCCATCAA

TGCGGCTGCATCTTTTACGTCCCTGCCGCATATACCTCTAAAATTGACCCCACCACC G

GATTCGTAAATATTTTTAAATTCAAGGACCTGACGGTGGACGCCAAGCGCGAATTCA

TCAAAAAATTCGACTCAATCCGCTATGATTCCGAAAAAAATCTTTTCTGCTTTACGT T

CGATTATAATAACTTCATTACCCAAAACACGGTGATGTCAAAATCGTCCTGGAGCGT

GTATACTTATGGAGTGCGTATCAAGCGCCGCTTTGTTAATGGGCGCTTCAGTAACGA

AAGCGATACCATCGACATTACCAAAGACATGGAGAAGACGCTTGAAATGACGGATA

TCAATTGGCGTGACGGACACGATCTTCGTCAGGATATCATCGACTACGAGATTGTGC

AACATATCTTTGAGATTTTCCGTTTAACTGTTCAAATGCGTAACTCCTTGTCCGAAT T

GGAAGACCGTGATTACGACCGCTTGATTTCACCAGTGCTTAACGAGAATAACATCTT CTACGACTCCGCCAAAGCAGGCGATGCCCTGCCAAAGGACGCTGATGCAAATGGTG

CATACTGTATCGCGTTGAAGGGCTTATACGAGATTAAGCAAATCACCGAAAATTGG

AAAGAGGATGGAAAGTTCAGTCGCGATAAGCTGAAGATCTCTAATAAAGATTGGTT

TGACTTTATCCAGAACAAACGTTATTTAAAACGTCCGGCAGCGACCAAAAAAGCCG

GCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAA

ACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0135] SEQ ID NO: 90

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGTACCA

ATAATTTCCAAAATTTCATCGGAATCTCATCCTTGCAAAAAACCTTGCGCAATGCTT T

GATCCCCACCGAAACCACGCAGCAGTTCATCGTGAAAAACGGCATTATCAAAGAGG

ATGAGTTGCGCGGGGAAAACCGTCAAATTCTTAAGGATATCATGGACGATTACTACC

GTGGGTTTATCAGTGAGACCCTGTCAAGCATTGACGACATTGACTGGACCAGCTTAT

TTGAGAAGATGGAGATTCAATTAAAGAACGGGGACAATAAGGACACGCTTATCAAA

GAGCAGACAGAATACCGTAAAGCGATTCATAAGAAATTTGCAAATGACGATCGCTT

CAAGAACATGTTTTCAGCAAAATTAATCAGCGACATCCTTCCCGAATTTGTGATTCA

TAATAACAACTATTCGGCTAGCGAAAAAGAGGAGAAAACTCAGGTTATTAAGCTTT

TCTCGCGTTTTGCCACTTCGTTCAAAGACTATTTTAAGAATCGCGCAAACTGCTTTT C

GGCTGATGATATTTCCAGTTCTAGCTGCCATCGTATCGTTAACGATAATGCTGAGAT

TTTCTTCTCTAATGCCCTGGTGTATCGTCGTATCGTTAAATCTTTGAGCAACGACGA T

ATTAATAAGATTTCAGGCGACATGAAGGATTCTTTAAAGGAGATGTCTTTAGAAGAG

ATTTATTCCTATGAGAAATATGGCGAGTTTATCACCCAAGAAGGAATTTCGTTCTAC

AACGACATCTGTGGCAAAGTGAACAGCTTCATGAATTTATACTGCCAAAAGAATAA

GGAGAATAAAAATTTATATAAACTGCAGAAACTGCATAAGCAAATTCTTTGCATTGC

AGACACCTCTTATGAAGTTCCTTATAAGTTTGAATCGGACGAGGAGGTATATCAGAG

TGTGAACGGGTTCCTGGACAATATTTCATCCAAGCATATTGTTGAACGTTTACGCAA

AATTGGAGACAATTACAATGGGTATAACCTTGACAAAATTTACATCGTGTCGAAGTT

TTACGAATCGGTAAGCCAGAAGACCTATCGTGACTGGGAAACTATCAATACCGCCTT

AGAAATTCATTACAACAATATTCTTCCTGGTAACGGCAAAAGCAAAGCCGATAAGG

TAAAGAAGGCTGTCAAGAACGACCTGCAAAAGTCTATCACAGAGATCAACGAGTTA

GTCTCTAACTACAAATTATGTTCCGACGACAATATTAAAGCCGAAACCTACATCCAT

GAGATCTCACACATTCTTAACAATTTTGAGGCCCAGGAGCTGAAATATAACCCAGAA

ATTCACCTTGTAGAGAGCGAATTAAAAGCCTCCGAGCTGAAGAACGTTTTGGATGTA

ATCATGAACGCATTTCATTGGTGCAGCGTATTTATGACAGAGGAGTTGGTCGACAAG

GACAATAACTTTTACGCCGAGCTTGAAGAAATCTACGATGAAATTTACCCGGTAATT

AGTTTATATAATTTAGTTCGCAACTACGTAACTCAGAAACCCTACAGTACCAAGAAG ATTAAATTGAACTTTGGGATCCCGACACTTGCTGACGGTTGGAGTAAATCAAAAGAA

TACTCCAATAATGCAATTATCCTGATGCGCGACAATCTTTACTACTTGGGGATCTTT A

ACGCAAAGAACAAACCAGATAAGAAAATCATCGAGGGCAACACCAGCGAGAATAA

AGGCGATTACAAGAAAATGATCTATAATCTTTTGCCGGGACCGAACAAAATGATCC

CAAAGGTTTTCCTGTCGTCGAAAACGGGAGTCGAGACATATAAACCATCTGCGTACA

TCTTGGAAGGTTACAAACAGAATAAGCATATTAAGTCTAGTAAAGACTTCGACATCA

CCTTTTGTCATGACCTGATTGATTATTTCAAGAACTGTATTGCTATCCATCCAGAAT G

GAAAAACTTCGGATTTGACTTCTCCGATACTAGCACCTACGAAGACATTTCGGGTTT

TTATCGCGAAGTAGAGCTTCAAGGGTACAAAATTGATTGGACATATATTAGCGAGA

AAGACATTGATTTGCTTCAAGAGAAGGGACAGTTATATTTATTCCAGATCTACAACA

AAGACTTCTCGAAGAAATCCACCGGTAATGATAATCTTCACACTATGTACCTGAAGA

ATTTATTTTCAGAGGAAAATCTGAAGGACATTGTACTTAAACTTAATGGAGAAGCCG

AAATCTTCTTCCGCAAGAGTTCCATTAAAAATCCGATTATTCATAAAAAGGGAAGTA

TCCTTGTGAACCGCACGTATGAGGCCGAAGAGAAGGATCAGTTTGGGAATATTCAA

ATTGTCCGCAAAAACATCCCCGAGAACATCTACCAGGAACTGTATAAATACTTTAAT

GATAAATCTGATAAAGAGTTATCAGACGAGGCTGCCAAACTGAAAAACGTAGTCGG

TCATCATGAGGCAGCGACCAATATTGTAAAGGACTACCGTTACACCTACGACAAGT

ATTTCCTTCACATGCCGATCACGATTAATTTTAAGGCTAACAAGACCGGCTTTATCA

ATGACCGCATCTTGCAGTACATCGCGAAAGAGAAAGATTTACACGTCATCGGAATT

GATCGTGGAGAGCGTAATCTTATCTACGTCAGCGTCATCGACACCTGTGGAAACATT

GTGGAACAAAAAAGTTTTAATATCGTAAACGGCTACGACTATCAAATTAAACTTAA

ACAGCAAGAGGGAGCTCGCCAGATCGCTCGCAAAGAGTGGAAAGAGATTGGGAAA

ATTAAAGAAATTAAAGAGGGTTACCTGTCGCTGGTAATTCACGAAATCTCGAAAAT

GGTCATCAAATATAATGCAATTATCGCTATGGAGGATCTGTCCTACGGGTTCAAGAA

GGGACGTTTTAAAGTAGAGCGCCAGGTGTATCAAAAATTCGAAACCATGTTGATCA

ATAAGCTTAACTATTTGGTCTTCAAAGATATTTCGATTACGGAGAACGGAGGTTTGT

TGAAAGGATATCAGCTGACGTATATCCCAGACAAGTTGAAAAACGTGGGGCATCAA

TGTGGATGTATTTTCTATGTGCCCGCGGCCTACACGAGTAAGATCGATCCTACCACT

GGTTTCGTCAACATTTTCAAATTTAAAGATCTTACCGTGGATGCGAAGCGCGAATTT

ATTAAGAAATTTGATAGCATTCGCTATGATTCCGAAAAGAACCTGTTCTGTTTTACG

TTCGACTATAACAATTTCATTACCCAAAACACGGTGATGAGCAAATCCTCTTGGTCA

GTTTATACATACGGTGTACGTATCAAACGCCGTTTCGTTAACGGACGCTTTTCCAAT

GAGTCTGATACAATCGATATCACGAAAGATATGGAAAAAACATTAGAGATGACTGA

TATCAACTGGCGTGACGGGCACGACCTGCGTCAAGACATTATTGACTACGAGATTGT

GCAGCATATCTTCGAAATCTTTCGCTTAACTGTGCAAATGCGTAACTCGTTATCCGA GTTAGAAGACCGTGACTACGATCGCCTGATTTCACCCGTCTTGAACGAAAATAACAT

CTTCTACGATTCCGCGAAGGCTGGGGACGCATTGCCCAAGGACGCAGACGCGAATG

GAGCGTACTGTATTGCGCTTAAAGGATTATATGAAATCAAGCAGATCACCGAAAATT

GGAAGGAGGACGGGAAGTTCTCACGCGACAAACTGAAGATTTCAAATAAGGACTGG

TTCGATTTCATTCAGAATAAGCGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0136] SEQ ID NO: 91

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGTACGAA

CAACTTTCAGAACTTCATCGGCATCTCCAGCCTTCAAAAGACTTTACGCAACGCATT

GATTCCCACGGAGACTACGCAACAGTTTATCGTAAAAAATGGTATTATCAAAGAAG

ATGAATTACGCGGGGAGAATCGCCAGATTCTTAAGGACATTATGGACGATTATTACC

GTGGATTCATCAGTGAGACACTGAGCTCCATTGATGACATCGACTGGACGTCATTGT

TTGAAAAGATGGAAATCCAGTTGAAAAATGGCGATAACAAAGATACATTGATTAAA

GAGCAGACAGAGTACCGCAAAGCAATTCACAAGAAATTCGCCAATGATGATCGTTT

TAAGAACATGTTTAGTGCCAAGCTTATTTCGGATATCTTACCCGAATTCGTGATTCA C

AACAACAATTATTCGGCAAGTGAGAAAGAGGAAAAGACCCAGGTTATCAAATTGTT

TTCGCGCTTCGCCACTTCGTTCAAAGATTATTTCAAGAACCGTGCAAACTGTTTCTC C

GCTGACGACATCAGTTCCAGCTCATGCCACCGTATTGTAAATGACAATGCGGAGATC

TTTTTCAGTAATGCCTTAGTATATCGTCGCATTGTAAAGAGCTTATCTAATGATGAC A

TTAACAAGATCTCGGGTGATATGAAGGACTCACTTAAGGAGATGAGTCTGGAAGAG

ATCTACTCCTACGAAAAATACGGGGAATTCATCACCCAGGAGGGAATTTCATTCTAC

AACGATATCTGCGGCAAAGTTAACTCCTTTATGAATCTGTACTGTCAAAAGAACAAG

GAGAATAAAAACCTGTATAAATTGCAGAAACTTCATAAACAAATTTTGTGTATCGCA

GACACGAGTTATGAAGTACCTTATAAATTCGAATCCGACGAAGAGGTATATCAGTCC

GTAAATGGGTTCCTGGACAATATCAGTAGTAAGCACATTGTGGAACGCTTACGCAA

AATTGGAGACAATTACAACGGGTATAACCTGGACAAAATCTACATCGTATCCAAATT

TTATGAAAGCGTGTCTCAAAAAACTTATCGTGATTGGGAAACAATCAACACGGCTCT

TGAGATCCATTACAATAACATCTTGCCGGGTAACGGCAAATCGAAGGCAGACAAAG

TTAAAAAAGCAGTTAAGAACGACTTACAGAAAAGCATTACGGAGATTAACGAGTTA

GTAAGTAATTACAAATTATGCTCCGACGATAATATCAAAGCTGAAACCTACATCCAT

GAAATTAGCCACATTTTGAACAATTTCGAAGCGCAGGAGCTGAAATATAACCCTGA

AATCCATCTGGTAGAGTCTGAGTTGAAGGCGTCAGAACTGAAAAACGTTCTTGACGT

CATCATGAATGCCTTTCACTGGTGTAGTGTTTTTATGACTGAGGAGCTTGTAGATAA

GGACAACAACTTCTATGCTGAACTTGAAGAGATCTACGATGAAATCTACCCCGTAAT CAGTCTGTATAATTTAGTTCGTAACTACGTCACGCAGAAACCCTATTCGACTAAGAA

AATTAAGCTGAACTTTGGGATCCCTACTTTGGCAGACGGGTGGAGCAAGAGTAAAG

AATACAGTAATAATGCAATTATCTTGATGCGCGATAACTTATATTACTTAGGTATTT T

CAATGCTAAGAACAAACCTGATAAGAAGATTATCGAAGGAAATACGAGTGAGAATA

AGGGAGACTACAAAAAGATGATTTACAACTTGCTGCCAGGGCCTAATAAGATGATT

CCAAAAGTTTTTCTGTCGAGCAAGACAGGGGTTGAAACTTATAAGCCATCCGCTTAT

ATCCTTGAGGGGTACAAGCAGAATAAGCATATCAAGTCCTCCAAAGATTTTGATATT

ACATTTTGCCACGACTTAATTGATTACTTCAAGAACTGCATCGCAATCCATCCCGAA

TGGAAGAATTTCGGCTTCGATTTCTCAGATACGTCCACGTATGAGGATATCTCAGGC

TTTTACCGCGAAGTTGAGCTGCAAGGTTATAAAATTGATTGGACATACATCTCCGAA

AAAGACATTGATCTTTTACAGGAAAAGGGCCAATTATACTTATTTCAAATCTATAAC

AAAGATTTTAGCAAGAAGTCCACAGGTAATGATAACCTGCATACGATGTATTTGAA

AAATCTTTTCAGTGAAGAGAATTTGAAGGATATCGTCCTGAAGCTGAACGGTGAGG

CTGAGATCTTCTTCCGCAAATCGTCTATCAAAAACCCCATCATTCACAAAAAGGGAA

GTATCTTAGTAAACCGCACTTATGAAGCGGAGGAAAAGGATCAGTTCGGGAACATC

CAGATCGTGCGCAAGAACATTCCAGAAAACATCTATCAGGAACTTTACAAATATTTC

AATGACAAGTCTGATAAAGAATTATCAGACGAGGCGGCGAAACTTAAAAATGTTGT

TGGACACCACGAAGCAGCGACGAATATTGTAAAGGATTATCGCTACACATACGATA

AATACTTTTTGCACATGCCAATCACCATTAACTTTAAGGCGAACAAGACAGGTTTCA

TTAACGACCGTATTCTGCAATATATCGCAAAGGAAAAAGACCTGCACGTTATTGGGA

TCGATCGTGGCGAACGCAATTTGATCTACGTAAGCGTTATCGACACTTGCGGAAATA

TCGTTGAACAAAAAAGCTTTAATATCGTCAATGGATACGATTACCAAATCAAGCTGA

AACAACAAGAAGGGGCACGTCAGATCGCTCGTAAAGAATGGAAAGAGATTGGTAA

GATCAAAGAGATTAAAGAAGGGTATCTTTCTTTAGTAATTCACGAGATTTCGAAAAT

GGTTATTAAATACAATGCGATTATTGCTATGGAAGACTTAAGCTACGGCTTTAAGAA

AGGTCGCTTCAAAGTGGAGCGCCAAGTGTATCAGAAGTTTGAAACGATGTTGATTA

ACAAATTAAATTACCTGGTCTTTAAGGACATCAGTATCACAGAAAATGGGGGGTTGC

TTAAAGGGTACCAGCTTACATACATCCCTGATAAACTGAAAAATGTCGGTCATCAGT

GCGGATGTATCTTCTATGTACCAGCAGCCTATACCAGTAAGATTGACCCTACTACTG

GCTTTGTGAATATTTTTAAATTCAAGGATTTAACCGTGGACGCCAAGCGTGAATTTA

TTAAAAAATTTGATTCGATTCGCTACGACAGTGAGAAAAACCTTTTCTGCTTTACCT T

TGACTACAACAATTTTATTACCCAGAACACCGTAATGTCAAAGAGTTCGTGGTCTGT

ATATACCTACGGTGTTCGCATCAAGCGCCGCTTCGTAAACGGGCGTTTCAGTAACGA

ATCTGACACCATCGACATCACTAAAGATATGGAGAAGACATTGGAAATGACGGACA

TTAATTGGCGTGATGGCCATGACTTACGTCAGGACATTATTGATTACGAAATTGTGC AGCATATCTTCGAGATTTTCCGTTTGACAGTTCAGATGCGCAACTCACTGAGTGAGT

TAGAAGATCGCGATTACGACCGTCTGATCTCACCGGTCCTTAATGAAAACAACATTT

TCTACGACTCAGCAAAGGCGGGTGATGCCCTGCCAAAGGATGCGGACGCTAATGGC

GCCTACTGCATCGCCCTGAAAGGATTGTATGAAATTAAGCAGATTACAGAAAATTG

GAAGGAAGATGGTAAATTTAGCCGTGATAAATTAAAAATCTCGAACAAGGATTGGT

TCGATTTTATTCAGAACAAACGTTATTTGAAACGTCCGGCAGCGACCAAAAAAGCCG

GCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAA

ACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0137] SEQ ID NO: 92

CC AGCGGCTAAAAA AAAGAA ACTGGATGGC AGCGT GGATATGAACAATGGAAC AA

ATAATTTTCAAAATTTTATCGGCATCTCAAGTCTTCAAAAAACCCTTCGCAATGCCC T

GATTCCAACTGAAACAACCCAGCAATTTATCGTCAAGAACGGCATCATTAAGGAAG

ACGAGTTACGCGGGGAGAACCGTCAAATCCTGAAAGATATCATGGATGACTACTAT

CGTGGGTTCATTTCGGAAACCTTGTCTTCAATCGACGACATTGACTGGACGAGTCTT

TTCGAGAAAATGGAAATTCAGCTTAAAAATGGAGACAACAAGGATACTCTGATTAA

GGAACAGACAGAATATCGCAAAGCTATCCACAAAAAGTTCGCTAATGATGATCGTT

TCAAAAATATGTTTTCTGCTAAATTGATTTCCGATATCTTGCCTGAATTTGTAATCC A

CAACAACAATTATTCTGCTTCCGAGAAGGAAGAGAAGACCCAGGTCATTAAATTATT

CAGCCGCTTTGCAACCAGCTTTAAAGACTACTTTAAGAATCGCGCTAACTGCTTTTC

GGCGGATGACATCTCATCATCATCATGCCACCGCATTGTGAACGACAATGCGGAGAT

CTTCTTTTCGAATGCGTTAGTTTATCGTCGCATTGTCAAAAGTCTTAGCAATGATGA C

ATCAACAAGATCTCAGGAGACATGAAAGATTCCTTAAAGGAGATGTCTCTTGAGGA

AATCTATTCGTATGAGAAATACGGCGAGTTCATTACCCAGGAAGGTATTAGTTTCTA

CAATGATATCTGCGGCAAAGTAAATTCTTTTATGAATCTGTATTGCCAAAAAAACAA

AGAAAACAAGAATCTTTATAAGTTACAAAAGTTACATAAGCAAATTCTGTGCATCGC

TGATACATCTTATGAGGTACCCTACAAATTTGAAAGTGATGAGGAGGTCTATCAGAG

TGTCAACGGCTTCTTAGACAACATCTCTTCCAAACATATCGTGGAACGCCTGCGTAA

AATCGGAGATAACTACAACGGATATAACTTAGATAAAATCTACATCGTGTCCAAGTT

TTATGAAAGTGTGAGCCAAAAAACATATCGTGACTGGGAAACCATTAACACCGCAT

TGGAAATTCACTATAACAACATTTTGCCAGGCAACGGGAAAAGTAAGGCGGACAAA

GTTAAGAAAGCAGTTAAAAATGACCTGCAAAAAAGCATCACTGAAATTAACGAATT

GGTATCGAATTACAAATTATGTAGCGACGATAATATCAAAGCAGAAACTTACATTCA

CGAGATTAGTCACATTTTAAATAACTTCGAGGCCCAGGAATTGAAATACAATCCCGA

AATTCATTTGGTTGAATCAGAACTGAAAGCATCAGAGTTGAAAAATGTGTTAGATGT

CATTATGAATGCGTTTCATTGGTGCTCTGTGTTCATGACCGAGGAACTGGTTGATAA AGATAACAACTTTTACGCTGAATTGGAGGAGATTTACGATGAGATTTACCCGGTCAT

TTCGCTTTATAACTTAGTGCGCAATTATGTGACGCAGAAACCATATTCCACGAAGAA

AATCAAACTTAATTTTGGCATCCCTACTCTGGCTGATGGTTGGTCGAAATCGAAAGA

GTACAGCAACAACGCGATCATTCTTATGCGTGACAATCTTTACTATTTGGGCATTTT T

AATGCCAAGAATAAGCCAGATAAGAAAATCATTGAGGGGAATACTTCCGAGAATAA

GGGGGATTACAAAAAGATGATCTATAACTTGCTGCCCGGCCCCAACAAAATGATTC

CTAAGGTTTTCTTGTCAAGCAAGACGGGCGTCGAAACATATAAGCCGTCAGCTTATA

TTCTGGAAGGCTATAAACAGAATAAGCACATCAAGTCTTCCAAGGACTTTGACATCA

CTTTTTGCCACGATTTGATCGACTACTTTAAGAACTGTATTGCGATTCATCCGGAAT G

GAAGAACTTCGGTTTCGACTTTTCCGATACCTCAACATACGAGGATATCAGCGGCTT

CTACCGTGAAGTCGAGCTTCAAGGCTACAAGATCGATTGGACATATATTTCAGAGAA

GGACATTGATTTGTTACAAGAGAAAGGTCAACTTTACTTATTTCAGATCTATAACAA

AGACTTTTCGAAGAAATCGACAGGAAACGATAACTTACACACTATGTATTTAAAAA

ATCTGTTTTCGGAGGAAAACCTGAAAGATATTGTGCTGAAACTTAACGGCGAGGCA

GAGATCTTTTTCCGTAAAAGCTCAATCAAGAATCCTATCATCCATAAAAAAGGTAGT

ATTCTTGTCAACCGCACATATGAAGCGGAGGAGAAGGACCAATTCGGAAACATCCA

AATTGTCCGTAAGAATATTCCGGAGAACATTTACCAAGAGTTGTATAAATACTTTAA

CGATAAGTCAGATAAGGAACTTAGCGATGAGGCGGCGAAGCTTAAAAACGTAGTTG

GGCATCATGAAGCTGCTACCAACATTGTAAAAGATTACCGTTACACCTATGACAAGT

ATTTCTTGCACATGCCCATTACGATCAATTTCAAAGCAAATAAGACAGGCTTTATCA

ATGATCGCATCCTGCAGTACATTGCTAAAGAGAAGGATTTGCATGTTATCGGTATTG

ATCGCGGAGAGCGCAATTTGATCTACGTCTCCGTAATCGACACTTGCGGTAACATTG

TTGAGCAGAAGTCGTTCAACATCGTTAATGGTTATGATTACCAAATCAAGCTGAAGC

AGCAAGAGGGTGCCCGCCAGATCGCGCGTAAGGAATGGAAAGAAATCGGGAAAAT

TAAAGAGATCAAAGAAGGCTATTTGTCTCTGGTAATTCACGAAATCAGCAAGATGG

TGATCAAGTATAACGCGATCATTGCGATGGAGGATCTTTCTTATGGCTTCAAGAAAG

GGCGCTTTAAAGTCGAACGCCAGGTCTACCAGAAATTTGAGACAATGCTTATCAACA

AGCTTAACTATCTTGTATTTAAGGATATTTCCATCACTGAGAACGGAGGACTTTTAA

AGGGGTACCAACTGACGTACATTCCTGATAAGCTGAAGAACGTTGGTCATCAATGC

GGATGCATCTTCTATGTGCCAGCGGCTTACACCTCCAAAATCGATCCCACTACAGGC

TTTGTCAATATCTTCAAATTCAAGGATTTGACCGTTGACGCGAAGCGCGAGTTTATC

AAGAAGTTTGATAGCATTCGCTACGACAGCGAAAAAAATTTATTTTGTTTTACTTTC

GACTACAATAACTTTATTACTCAGAACACTGTCATGTCAAAGAGTTCGTGGAGTGTC

TACACGTACGGAGTACGTATTAAGCGCCGTTTCGTCAACGGACGCTTCTCAAACGAA

AGCGACACGATCGACATCACCAAAGACATGGAAAAAACTCTTGAGATGACGGATAT CAATTGGCGCGACGGCCATGACCTGCGTCAGGATATCATTGATTACGAGATCGTTCA

GCACATCTTCGAAATCTTCCGCCTTACCGTCCAGATGCGCAACAGTTTAAGCGAGCT

TGAAGACCGCGACTACGATCGTTTGATTAGCCCCGTTCTGAACGAGAATAATATTTT

CTACGACAGCGCAAAGGCCGGTGATGCTTTGCCAAAGGACGCAGACGCGAATGGAG

CCTACTGCATCGCCCTGAAGGGCTTATATGAGATTAAGCAAATTACCGAAAATTGGA

AGGAAGATGGTAAGTTCTCCCGTGATAAGCTTAAAATTAGCAATAAGGATTGGTTCG

ACTTCATCCAGAACAAACGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCCGGC

CAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAAAC

GTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0138] SEQ ID NO: 93

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAACAA

ACAATTTCCAAAACTTCATCGGTATCTCTTCGTTGCAGAAGACTCTGCGTAATGCTT T

GATCCCGACGGAGACAACCCAACAATTTATCGTCAAAAACGGTATTATTAAGGAGG

ACGAGTTACGTGGAGAAAATCGTCAAATCCTTAAGGACATCATGGACGATTATTATC

GCGGGTTTATTTCTGAAACCCTGAGCAGTATCGATGATATCGACTGGACCTCACTTT

TTGAGAAAATGGAGATCCAGTTGAAGAACGGTGATAACAAAGACACTCTGATCAAA

GAGCAAACTGAATACCGCAAGGCAATTCACAAAAAGTTCGCCAACGACGACCGTTT

CAAGAATATGTTCTCAGCTAAGTTAATCAGCGACATTTTGCCAGAGTTCGTTATCCA

CAACAATAATTATAGTGCTTCAGAGAAGGAGGAAAAAACCCAAGTGATTAAACTTT

TTTCGCGCTTTGCAACCTCATTCAAGGACTACTTCAAGAATCGCGCGAATTGCTTCA

GTGCGGACGACATTTCTTCTTCAAGTTGCCATCGTATCGTTAACGATAACGCGGAAA

TTTTCTTCTCTAATGCTTTGGTGTATCGCCGCATTGTAAAATCGCTTAGTAACGATG A

CATTAATAAGATCTCAGGTGATATGAAAGATTCATTGAAGGAAATGAGCTTGGAAG

AGATTTACAGTTACGAAAAATATGGAGAATTTATTACTCAGGAAGGCATCTCATTCT

ATAACGATATCTGCGGGAAGGTAAATTCGTTTATGAACTTATATTGCCAGAAAAATA

AAGAGAATAAAAATTTGTATAAGCTTCAGAAGTTGCACAAACAGATCCTGTGCATT

GCAGACACCTCGTATGAGGTTCCGTATAAATTTGAGTCCGATGAAGAAGTGTATCAG

TCTGTGAATGGTTTCTTAGATAATATCTCTTCCAAGCATATTGTCGAACGCCTGCGC A

AAATTGGTGATAACTATAACGGATACAATCTGGATAAAATTTACATCGTTTCTAAAT

TTTACGAGTCAGTCTCGCAGAAGACCTACCGCGACTGGGAAACAATTAACACGGCA

TTGGAGATTCACTACAATAATATCTTGCCTGGTAACGGTAAGTCTAAGGCAGATAAG

GTAAAAAAAGCTGTGAAAAACGACCTTCAGAAAAGCATCACGGAGATTAATGAGCT

GGTGAGTAATTACAAATTATGTTCAGACGATAATATTAAAGCTGAAACGTATATCCA

TGAAATCTCGCATATCTTGAACAACTTCGAGGCCCAAGAACTTAAATATAACCCCGA

AATCCATTTAGTCGAGTCTGAATTGAAAGCGTCGGAATTAAAAAACGTCTTAGACGT CATTATGAACGCGTTTCACTGGTGTTCAGTTTTCATGACCGAAGAGCTGGTCGACAA

AGACAACAACTTCTATGCGGAATTGGAGGAAATCTATGATGAAATCTACCCTGTTAT

TTCACTGTATAACCTTGTGCGCAACTATGTCACTCAGAAGCCGTATTCGACCAAAAA

AATTAAATTGAATTTCGGTATCCCTACTCTTGCAGACGGATGGAGTAAAAGCAAGGA

ATACAGTAATAACGCCATTATTCTTATGCGCGACAATTTATACTACCTGGGCATCTT T

AACGC AAA GAATAAGCCGGATAAGAA GATT ATTGAGGGTAACACCAGTGAGAACA

AGGGCGACTATAAGAAGATGATCTATAACTTATTGCCAGGTCCAAATAAAATGATC

CCAAAAGTATTCTTATCATCAAAGACGGGAGTTGAAACCTATAAGCCTAGTGCCTAT

ATTCTTGAGGGATATAAACAGAACAAGCACATTAAGTCGTCTAAGGATTTTGACATT

ACGTTCTGCCATGACTTAATCGACTATTTTAAAAACTGTATTGCGATTCACCCCGAA T

GGAAGAATTTTGGATTCGATTTTTCGGATACCTCGACCTATGAAGATATTTCGGGAT

TTTATCGTGAAGTGGAGTTGCAAGGCTATAAAATCGATTGGACCTATATCTCAGAAA

AAGACATTGATTTATTACAGGAAAAGGGACAACTGTACCTTTTCCAAATTTATAACA

AGGACTTTTCTAAAAAGTCCACAGGAAATGATAACCTTCACACCATGTACCTGAAGA

ACCTTTTCTCAGAGGAAAACCTGAAGGACATTGTCCTTAAGTTAAATGGAGAAGCG

GAGATCTTTTTCCGTAAATCTAGTATCAAGAATCCGATTATCCATAAAAAAGGTTCG

ATTTTGGTAAATCGCACCTATGAAGCGGAAGAGAAAGATCAATTTGGTAACATCCA

GATCGTGCGCAAGAATATCCCGGAGAACATTTACCAAGAGCTGTATAAGTACTTCA

ATGATAAGTCTGATAAGGAACTGTCAGATGAAGCTGCGAAATTGAAGAACGTGGTT

GGGCATCATGAAGCCGCTACCAATATCGTCAAGGATTACCGTTATACCTATGACAAA

TATTTCTTACACATGCCGATTACGATCAATTTTAAGGCAAACAAGACAGGATTCATC

AACGACCGTATCTTGCAGTATATTGCCAAAGAGAAGGATCTGCATGTGATCGGTATT

GACCGCGGGGAGCGCAATTTAATCTATGTATCGGTGATCGATACTTGTGGTAACATC

GTAGAACAAAAGAGCTTTAACATCGTGAATGGTTACGACTATCAGATCAAGCTGAA

ACAACAGGAAGGAGCCCGCCAGATCGCTCGCAAGGAATGGAAAGAAATCGGGAAA

ATTAAGGAAATCAAGGAAGGCTACCTTTCATTGGTCATTCACGAAATTTCGAAAATG

GTAATTAAGTACAACGCGATCATCGCCATGGAGGACCTTTCGTACGGATTTAAGAAG

GGTCGTTTCAAAGTTGAGCGCCAGGTATACCAAAAATTCGAGACTATGCTTATCAAC

AAACTTAACTACTTGGTCTTTAAGGACATTTCTATTACCGAAAACGGCGGCTTACTT

AAAGGCTATCAATTGACATATATTCCCGACAAACTGAAGAATGTTGGACATCAATGC

GGGTGTATTTTCTATGTGCCGGCAGCTTACACTAGTAAGATCGACCCTACAACCGGG

TTCGTAAACATTTTTAAATTCAAAGACTTAACAGTCGATGCGAAGCGTGAATTTATT

AAGAAGTTTGATAGTATCCGCTATGACAGTGAAAAGAACTTGTTTTGCTTTACGTTC

GACTACAATAACTTTATTACACAGAACACGGTCATGTCTAAATCATCATGGTCGGTT

TACACATATGGGGTGCGCATCAAGCGTCGCTTTGTAAATGGCCGTTTTAGTAATGAG AGCGACACAATCGACATCACAAAGGATATGGAGAAAACTCTTGAGATGACAGACAT

CAATTGGCGTGACGGTCATGACTTACGCCAAGATATCATCGACTACGAAATCGTACA

GCATATTTTTGAGATTTTTCGTCTTACTGTGCAAATGCGTAATTCTTTATCCGAACT G

GAAGATCGTGATTACGACCGCTTGATTAGTCCCGTCTTAAATGAGAACAATATTTTC

TATGATTCTGCGAAAGCCGGAGATGCACTGCCCAAAGACGCTGATGCCAATGGCGC

GTATTGCATTGCATTAAAAGGATTATATGAGATTAAACAGATTACCGAAAATTGGAA

AGAGGACGGTAAATTCTCACGCGATAAATTGAAGATTTCTAACAAGGACTGGTTCG

ACTTTATCCAAAATAAACGTTATCTTAAACGTCCGGCAGCGACCAAAAAAGCCGGC

CAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAAAC

GTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0139] SEQ ID NO: 94

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGTACCAA

CAACTTTCAGAATTTCATTGGCATTAGCTCGCTTCAAAAAACTTTACGCAATGCTCT T

ATTCCGACTGAGACGACACAACAGTTTATCGTTAAGAATGGCATCATCAAAGAAGA

TGAATTACGCGGAGAAAACCGCCAGATCCTGAAAGACATTATGGACGATTATTACC

GTGGGTTCATCTCCGAGACGTTGTCATCGATCGATGACATCGACTGGACGTCACTTT

TTGAAAAAATGGAGATCCAGTTAAAGAACGGTGACAATAAGGATACATTGATCAAA

GAACAGACCGAGTACCGTAAAGCGATTCATAAAAAGTTTGCGAACGATGATCGCTT

CAAGAATATGTTTTCTGCGAAATTAATTTCCGACATTTTACCTGAATTTGTTATTCA T

AATAACAACTACTCGGCGTCTGAGAAAGAGGAGAAAACCCAAGTGATTAAACTTTT

TTCACGTTTCGCAACGTCGTTCAAAGACTATTTTAAAAATCGTGCTAATTGCTTTAG C

GCGGATGACATCAGCTCTAGTTCATGTCATCGCATTGTCAACGATAATGCTGAGATC

TTTTTCAGTAATGCGTTAGTGTACCGTCGTATTGTGAAGTCCTTATCTAATGATGAT A

TCAATAAGATCAGCGGGGATATGAAGGACTCACTTAAGGAGATGAGCTTGGAGGAA

ATCTATTCCTATGAGAAGTATGGTGAGTTTATTACGCAAGAAGGAATTAGCTTTTAC

AACGATATCTGTGGAAAGGTGAATTCGTTTATGAATTTGTATTGCCAGAAAAATAAG

GAGAACAAGAACCTTTATAAATTGCAAAAGTTACACAAGCAAATCCTGTGCATTGC

AGATACTTCCTACGAGGTGCCTTACAAGTTTGAATCCGACGAAGAGGTCTACCAATC

TGTAAACGGTTTCTTAGATAATATTAGTTCCAAGCATATTGTGGAGCGCCTTCGTAA

AATTGGCGATAATTACAACGGTTACAATTTAGACAAAATTTACATTGTCAGTAAATT

CTACGAGTCCGTATCTCAAAAGACGTATCGTGATTGGGAGACTATCAATACGGCCCT

GGAGATCCACTACAACAATATCTTGCCCGGTAATGGTAAGTCGAAGGCCGATAAAG

TTAAGAAAGCGGTGAAAAATGACTTACAGAAGTCAATCACCGAAATTAACGAATTG

GTGTCCAATTATAAATTGTGTTCAGATGATAATATCAAAGCCGAGACCTACATTCAT

GAGATTTCCCATATCTTAAATAATTTCGAGGCGCAAGAGCTTAAGTATAACCCAGAA ATCCACCTGGTAGAATCTGAGTTGAAGGCGTCAGAGTTAAAAAATGTTTTAGATGTC

ATTATGAACGCGTTTCACTGGTGCTCCGTATTTATGACGGAGGAATTAGTAGATAAA

GACAACAATTTCTATGCCGAACTTGAGGAAATCTATGATGAGATCTATCCCGTCATT

AGCCTGTATAACTTGGTCCGCAACTATGTTACCCAAAAACCGTACAGTACCAAGAAG

ATTAAGCTGAATTTCGGCATTCCTACACTGGCTGATGGTTGGAGTAAATCGAAGGAA

TATTCGAATAACGCGATTATCTTGATGCGCGACAACTTATACTATTTGGGGATCTTT A

ACGCCAAAAACAAACCGGATAAGAAGATTATTGAGGGAAACACATCAGAGAACAA

AGGCGACTACAAAAAAATGATTTACAACTTGTTACCGGGGCCTAACAAAATGATCC

CGAAGGTGTTCTTATCCAGTAAAACAGGCGTTGAGACCTACAAACCTTCCGCATACA

TCCTGGAAGGGTATAAGCAGAACAAGCACATTAAGTCCAGCAAGGATTTCGATATT

ACCTTCTGTCATGATTTAATTGACTATTTCAAGAACTGTATTGCAATCCACCCCGAG T

GGAAGAACTTCGGATTCGACTTCTCAGATACGAGCACATATGAGGACATCTCGGGG

TTCTATCGTGAAGTAGAACTGCAGGGATATAAAATTGATTGGACATATATTTCCGAA

AAAGACATCGACCTTTTACAAGAGAAGGGTCAACTTTACTTGTTCCAAATTTACAAT

AAAGACTTCTCAAAAAAAAGCACGGGTAACGATAATTTACACACTATGTATTTAAA

GAACCTTTTCTCGGAAGAGAATTTAAAGGATATCGTATTGAAGTTGAATGGAGAAG

CGGAGATCTTCTTCCGTAAGTCCAGTATTAAAAACCCTATTATTCACAAGAAGGGAT

CGATTTTAGTTAACCGCACATACGAGGCCGAAGAGAAGGACCAATTTGGGAACATT

CAAATTGTCCGCAAAAACATCCCTGAGAACATTTATCAAGAGCTTTATAAGTACTTT

AACGATAAGTCCGATAAGGAATTGTCAGATGAGGCGGCAAAGTTGAAGAATGTCGT

GGGGCATCATGAAGCTGCCACCAACATTGTGAAGGACTACCGCTACACTTACGACA

AATACTTCCTGCACATGCCCATTACGATCAATTTTAAGGCCAATAAGACAGGCTTTA

TTAACGACCGTATTCTTCAATATATCGCTAAGGAGAAGGACCTTCATGTGATTGGGA

TCGACCGCGGAGAACGTAATTTAATTTATGTGTCCGTCATCGATACGTGTGGAAATA

TCGTGGAACAGAAATCATTCAATATCGTGAATGGCTATGATTACCAGATCAAATTAA

AACAGCAGGAGGGCGCTCGCCAAATTGCGCGTAAGGAATGGAAAGAGATCGGAAA

AATCAAAGAAATCAAAGAAGGATATTTGTCATTGGTGATCCATGAGATTTCAAAAA

TGGTAATTAAATATAATGCAATTATCGCAATGGAAGACCTGTCCTATGGTTTTAAGA

AGGGTCGTTTCAAGGTAGAACGCCAAGTGTATCAAAAGTTCGAGACGATGCTGATC

AATAAGCTGAATTATCTTGTGTTTAAGGACATTAGCATCACGGAAAATGGAGGGCTG

TTGAAAGGCTATCAACTGACGTATATCCCTGACAAGCTGAAAAATGTTGGCCATCAG

TGCGGGTGCATTTTCTACGTCCCCGCGGCGTATACAAGCAAGATCGATCCTACTACG

GGATTCGTAAATATTTTTAAATTCAAAGACTTAACCGTGGACGCCAAGCGCGAATTC

ATTAAGAAGTTTGATAGCATTCGCTACGATTCAGAAAAAAATCTTTTCTGTTTTACG T

TCGATTACAACAATTTTATCACCCAGAACACAGTGATGAGCAAGTCATCCTGGTCTG TCTATACCTACGGTGTCCGTATCAAACGCCGCTTCGTCAACGGACGCTTCTCTAATG

AATCTGATACCATTGACATCACCAAGGACATGGAAAAGACACTTGAGATGACAGAT

ATTAACTGGCGTGACGGACATGACCTGCGTCAGGACATCATCGATTATGAGATTGTT

CAGCATATCTTCGAGATCTTCCGCCTGACAGTACAAATGCGCAATTCACTGTCAGAA

CTTGAAGACCGCGACTATGACCGCCTGATCTCTCCAGTATTAAATGAGAACAATATC

TTTTATGACAGTGCTAAGGCCGGCGATGCCCTTCCGAAAGATGCTGATGCTAACGGA

GCTTATTGTATTGCATTAAAGGGTCTTTATGAGATCAAGCAAATTACCGAGAATTGG

AAGGAGGAT GGC AAATTCTCGCGCGAC AAACT GAAAATC AGT AACA AGGACTGGTT

CGATTTTATTCAGAATAAACGTTACCTGAAACGTCCGGCAGCGACCAAAAAAGCCG

GCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGAA

ACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0140] SEQ ID NO: 95

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGAACGA

ACAACTTCCAGAACTTCATCGGCATCAGTTCTTTACAAAAAACCCTGCGTAACGCCC

TTATTCCGACTGAGACAACACAACAGTTCATCGTTAAAAACGGAATTATCAAAGAG

GACGAGTTGCGCGGCGAGAATCGCCAAATTTTGAAAGATATTATGGACGACTATTAT

CGTGGTTTTATTTCAGAAACACTGAGTTCGATTGACGATATCGATTGGACGAGCCTG

TTTGAGAAAATGGAAATCCAGTTGAAAAATGGCGATAATAAAGACACTTTAATCAA

AGAACAAACCGAGTATCGTAAAGCGATCCATAAAAAGTTCGCTAATGACGATCGTT

TTAAGAATATGTTCAGTGCGAAACTGATTTCAGACATTTTGCCCGAGTTCGTGATCC

ATAATAACAACTATTCCGCCTCGGAAAAGGAAGAAAAAACCCAGGTGATTAAGCTG

TTCAGTCGCTTCGCAACATCTTTCAAGGATTATTTCAAGAATCGCGCGAATTGCTTC A

GTGCGGACGATATTTCTAGTTCAAGCTGCCATCGTATCGTTAATGATAACGCGGAGA

_{TTTTTTTTAGCAATGCTCTGGTGTACCGCCGCATTGTTAAGTCACTGTCCAACGA TGA}

TATTAACAAGATCTCAGGAGACATGAAAGACTCGCTTAAAGAGATGAGTCTGGAAG

AGATCTATTCTTATGAGAAGTATGGCGAGTTTATTACCCAAGAAGGAATCTCATTCT

ACAATGATATTTGTGGAAAGGTGAACAGCTTTATGAATCTTTACTGCCAAAAAAACA

AGGAGAATAAGAATCTTTACAAACTTCAGAAGTTACATAAACAGATTTTGTGTATTG

CGGATACGTCTTATGAAGTCCCCTACAAATTTGAATCGGATGAAGAGGTATACCAAA

GTGTGAACGGATTCTTGGACAATATTTCTTCTAAACATATTGTTGAACGCTTACGTA

AGATCGGGGATAACTACAATGGCTACAATCTTGACAAAATCTACATTGTTAGCAAAT

TCTACGAGAGTGTCAGCCAAAAGACGTACCGCGATTGGGAAACAATTAATACTGCG

CTTGAGATTCACTATAATAACATTTTACCAGGCAACGGCAAGTCCAAGGCGGATAA

AGTTAAAAAAGCTGTTAAAAACGATTTGCAAAAATCTATCACAGAAATTAACGAGT

TAGTTAGTAACTACAAACTGTGCTCCGATGACAACATTAAGGCTGAGACGTATATCC ATGAGATCTCTCACATCTTAAACAATTTTGAAGCTCAAGAACTTAAGTACAATCCGG

AAATCCACCTGGTGGAATCCGAGCTGAAGGCTAGCGAACTGAAGAACGTATTGGAC

GTGATCATGAACGCGTTCCACTGGTGTTCTGTCTTTATGACGGAAGAGCTTGTCGAC

AAAGATAATAACTTTTACGCGGAACTTGAGGAAATTTACGATGAGATTTACCCAGTT

ATTTCATTGTATAACCTTGTCCGTAATTACGTGACCCAAAAGCCTTATAGTACGAAA

AAAATCAAATTAAATTTTGGAATCCCAACACTGGCTGACGGTTGGAGCAAATCTAA

GGAGTATTCTAATAACGCAATCATCTTAATGCGTGACAACCTGTATTATTTGGGTAT

CTTCAATGCCAAAAATAAGCCTGACAAAAAGATTATCGAAGGAAATACTTCGGAGA

ATAAGGGGGATTACAAAAAAATGATTTACAATTTGCTGCCCGGGCCGAACAAGATG

ATCCCCAAAGTGTTCTTATCCTCGAAGACTGGTGTAGAAACATACAAGCCAAGCGCA

TACATTCTGGAGGGTTACAAGCAAAACAAACACATCAAATCTTCAAAAGACTTTGA

CATTACATTTTGCCATGATCTTATTGACTACTTCAAAAACTGCATTGCTATTCACCC C

GAGTGGAAGAACTTTGGGTTTGACTTCAGCGACACGTCTACGTATGAGGACATCTCC

GGGTTCTACCGTGAAGTTGAGTTACAAGGGTATAAGATTGACTGGACGTATATTTCA

GAGAAAGATATCGATCTTTTGCAGGAAAAGGGCCAGTTATATTTATTCCAGATTTAC

AACAAGGACTTTAGTAAGAAGTCAACAGGAAATGACAACTTGCATACGATGTATTT

GAAAAATCTTTTTTCTGAGGAAAATCTTAAGGACATCGTACTGAAATTGAATGGCGA

GGCTGAAATCTTCTTCCGTAAATCCTCCATTAAGAATCCCATTATCCACAAAAAGGG

GTCTATCCTGGTGAATCGTACCTACGAGGCAGAGGAGAAGGATCAATTCGGAAATA

TTCAGATTGTTCGTAAGAACATCCCCGAGAACATTTATCAAGAATTGTATAAGTACT

TTAATGACAAATCTGACAAAGAGTTATCCGACGAAGCTGCGAAACTGAAAAACGTT

GTTGGTCACCACGAGGCCGCCACTAATATCGTAAAAGACTACCGTTATACCTATGAC

AAGTACTTTTTGCACATGCCGATCACTATCAACTTCAAGGCGAATAAGACGGGCTTC

ATTAACGATCGTATCCTGCAATACATCGCCAAGGAGAAGGACCTTCACGTCATTGGG

ATTGACCGTGGTGAGCGTAACCTGATTTATGTAAGCGTCATTGATACCTGCGGTAAT

ATCGTCGAACAGAAAAGTTTCAACATTGTAAATGGATATGACTATCAGATCAAACTT

AAGCAGCAGGAGGGTGCACGCCAGATTGCCCGCAAGGAATGGAAGGAGATTGGGA

AGATTAAGGAAATTAAAGAAGGTTACTTATCACTGGTTATTCACGAGATCAGTAAA

ATGGTAATCAAATATAACGCGATCATTGCCATGGAGGATCTGAGCTATGGCTTTAAA

AAGGGCCGTTTCAAAGTCGAGCGCCAGGTATATCAAAAGTTTGAAACAATGCTGAT

TAACAAATTAAACTATCTGGTTTTCAAAGATATTTCGATCACTGAAAATGGCGGGCT

GTTGAAGGGATACCAACTTACATACATCCCTGACAAACTGAAAAATGTCGGTCACC

AATGTGGATGTATCTTTTATGTACCAGCAGCGTATACGAGCAAAATCGATCCAACTA

CGGGTTTTGTGAACATCTTTAAGTTCAAGGATTTGACAGTAGATGCCAAACGCGAGT

TCATTAAAAAATTTGATTCAATTCGCTACGATTCAGAGAAAAATCTTTTTTGTTTCA C GTTCGATTACAATAATTTCATTACGCAGAACACAGTAATGTCAAAGTCAAGCTGGTC

GGTCTACACGTATGGAGTCCGTATTAAACGTCGTTTTGTAAACGGCCGTTTCTCAAA

TGAATCAGATACAATTGATATTACGAAGGATATGGAGAAGACATTAGAGATGACTG

ACATTAACTGGCGCGACGGACATGATCTTCGTCAGGACATTATTGATTATGAGATTG

TACAGCATATCTTTGAGATCTTCCGCCTGACCGTTCAGATGCGCAATTCGTTGTCCG A

GTTAGAAGACCGCGATTACGACCGTTTAATCAGTCCCGTCTTAAACGAAAATAACAT

CTTCTACGATTCAGCCAAGGCAGGCGATGCCTTGCCAAAGGATGCTGACGCAAATG

GCGCATACTGTATTGCGTTGAAAGGCCTTTATGAAATCAAGCAAATTACCGAAAACT

GGAAAGAAGACGGAAAATTCTCCCGTGATAAGTTGAAAATCTCTAATAAGGATTGG

TTCGATTTCATCCAAAATAAACGCTATTTGAAACGTCCGGCAGCGACCAAAAAAGCC

GGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAAGA

AACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0141] SEQ ID NO: 96

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAACTA

ATAATTTCCAAAATTTTATAGGCATCTCTTCTTTACAGAAGACTCTTCGTAACGCCC T

AATCCCGACTGAGACCACACAACAATTCATAGTGAAAAATGGGATCATTAAAGAAG

ACGAGCTGCGTGGGGAGAACAGGCAGATCCTAAAAGACATAATGGACGATTATTAT

AGAGGGTTCATCTCAGAGACATTATCTAGCATCGACGACATTGACTGGACCTCCCTG

TTTGAAAAAATGGAAATCCAGCTGAAGAATGGTGACAATAAAGACACATTAATAAA

AGAACAAACAGAGTACAGGAAAGCCATCCACAAGAAGTTCGCAAACGATGACAGA

TTCAAAAATATGTTCAGTGCGAAGCTAATATCCGACATCTTACCAGAGTTTGTAATA

CACAATAACAATTACAGCGCGAGCGAAAAGGAAGAGAAAACGCAAGTAATTAAGC

TTTTTAGTAGGTTCGCTACCTCTTTCAAAGATTACTTCAAAAATCGTGCTAACTGCT T

CTCAGCCGACGACATATCTTCAAGTTCCTGTCACCGTATCGTGAATGATAACGCTGA

GATATTCTTCTCAAACGCCCTTGTATACCGTAGGATCGTAAAGTCCTTATCTAACGA T

GATATAAACAAGATCAGTGGAGACATGAAAGACAGCCTTAAAGAGATGTCTCTAGA

AGAAATTTACTCCTATGAAAAGTATGGGGAGTTTATAACACAGGAGGGGATCAGCT

TCTACAACGACATCTGCGGAAAGGTGAACAGTTTCATGAATCTTTACTGCCAGAAGA

ATAAAGAGAACAAAAATCTTTATAAGCTTCAAAAGTTGCACAAACAAATACTGTGC

ATTGCCGATACATCATATGAGGTCCCCTATAAGTTCGAATCTGATGAGGAAGTTTAT

CAATCTGTTAACGGCTTTCTAGACAATATCAGCTCAAAACACATCGTAGAAAGACTG

AGGAAAATAGGTGATAATTATAATGGATACAACTTGGATAAAATATATATAGTCTCT

AAATTTTACGAGTCAGTATCCCAGAAAACGTATAGGGATTGGGAGACCATCAACAC

GGCGTTAGAGATTCATTACAATAACATCTTACCGGGAAACGGAAAAAGTAAGGCGG

ACAAAGTAAAGAAAGCCGTTAAAAATGACTTACAAAAGAGTATAACAGAAATAAA CGAACTAGTAAGCAACTACAAGCTTTGTTCCGATGATAATATCAAGGCCGAGACAT

ATATCCATGAGATCTCCCACATTCTAAACAATTTCGAAGCGCAAGAACTTAAATATA

ATCCCGAAATCCACCTGGTGGAAAGTGAACTAAAGGCTAGTGAGTTAAAGAACGTT

CTTGATGTTATCATGAACGCCTTCCATTGGTGCTCTGTTTTTATGACCGAGGAGTTG G

TTGATAAAGATAATAATTTCTACGCTGAATTAGAGGAGATATACGACGAAATCTACC

CAGTGATTTCACTATACAACTTGGTCAGGAACTATGTTACACAAAAGCCGTACAGCA

CTAAGAAAATTAAGCTAAATTTCGGTATCCCCACGTTAGCCGACGGGTGGAGCAAG

TCCAAAGAATATTCCAACAATGCGATTATTTTAATGCGTGACAATCTTTATTACCTT G

GCATCTTCAATGCCAAAAACAAACCTGACAAAAAGATTATAGAAGGTAATACGTCC

GAGAACAAAGGCGATTACAAGAAGATGATTTATAACCTACTGCCCGGACCAAACAA

AATGATCCCCAAAGTTTTTCTTAGTTCTAAAACCGGCGTAGAGACGTATAAACCTTC

TGCCTATATCTTAGAGGGATATAAGCAGAACAAACATATCAAATCTTCCAAGGACTT

TGATATTACATTCTGCCACGATTTAATTGACTACTTCAAAAATTGCATAGCGATACA

TCCGGAGTGGAAGAACTTTGGCTTCGACTTCAGTGATACATCCACCTATGAGGATAT

ATCAGGCTTCTATCGTGAGGTCGAATTGCAAGGGTACAAAATCGATTGGACGTATAT

ATCCGAGAAAGACATAGACCTTCTTCAAGAAAAGGGGCAGTTATATTTATTCCAAAT

ATACAACAAGGACTTCAGTAAGAAGTCAACAGGTAATGACAACTTACACACCATGT

ACTTGAAAAATTTATTTTCTGAAGAAAACCTAAAGGACATTGTACTAAAACTGAACG

GGGAGGCAGAAATTTTTTTTAGAAAGAGCAGCATAAAAAACCCAATAATTCATAAG

AAAGGAAGCATTTTAGTTAATAGGACGTACGAGGCAGAGGAAAAGGACCAGTTTGG

CAATATCCAGATCGTAAGGAAAAATATTCCTGAAAACATATATCAGGAACTATATA

AATACTTTAACGACAAATCCGACAAAGAATTATCCGACGAGGCTGCAAAGCTGAAG

AACGTCGTAGGGCACCATGAGGCAGCGACTAATATTGTGAAAGACTATAGGTATAC

ATACGACAAATACTTTCTGCACATGCCCATCACGATTAACTTCAAGGCGAACAAGAC

GGGATTCATTAACGACCGTATATTACAATATATTGCTAAGGAGAAAGATCTGCATGT

AATAGGTATCGACAGAGGCGAACGTAATTTAATCTACGTGTCCGTCATCGACACGTG

CGGGAACATCGTAGAGCAAAAGAGTTTTAATATAGTAAATGGCTATGATTACCAAA

TTAAGCTAAAGCAGCAAGAAGGAGCAAGACAGATAGCTAGGAAAGAATGGAAGGA

GATAGGAAAAATAAAGGAGATCAAGGAGGGGTATCTTAGCCTAGTAATTCATGAAA

TATCTAAGATGGTTATCAAATACAACGCTATCATAGCGATGGAAGACTTATCTTATG

GTTTCAAGAAAGGAAGGTTCAAAGTAGAGCGTCAAGTTTATCAAAAGTTCGAAACG

ATGTTGATTAATAAACTAAACTATTTGGTATTTAAAGATATATCTATCACCGAGAAT

GGTGGTCTACTAAAGGGTTACCAGCTTACATACATACCGGACAAACTTAAAAACGTC

GGACATCAGTGTGGATGCATTTTCTACGTTCCAGCTGCATATACCAGCAAGATCGAC

CCAACGACTGGGTTCGTAAATATTTTTAAATTCAAGGATTTGACTGTCGACGCCAAA AGAGAGTTCATAAAAAAGTTCGATTCAATTAGGTACGACAGCGAAAAGAATTTGTT

CTGCTTTACTTTTGACTATAACAATTTCATTACTCAGAACACTGTAATGTCTAAGTC C

TCTTGGTCAGTCTATACTTATGGCGTTCGTATCAAACGTAGATTTGTTAACGGTAGA T

TCTCAAATGAAAGTGATACAATAGATATCACGAAAGATATGGAGAAAACATTAGAA

ATGACAGACATAAACTGGAGAGACGGACATGACTTGAGACAGGACATTATTGACTA

CGAGATCGTGCAGCACATCTTTGAGATCTTTCGTTTGACCGTACAAATGCGTAACAG

TTTATCTGAGCTTGAGGACAGGGACTACGATAGATTGATATCACCTGTATTAAATGA

GAATAACATCTTCTATGATTCCGCAAAAGCAGGCGACGCTCTACCCAAAGACGCTG

ATGCGAACGGTGCTTATTGCATAGCTTTAAAGGGTTTGTATGAGATCAAACAGATAA

CAGAAAATTGGAAGGAAGATGGTAAGTTCTCCCGTGACAAGCTTAAAATATCAAAT

AAGGACTGGTTCGATTTTATACAGAATAAGCGTTATTAAAACGTCCGGCAGCGACCA

AAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCC

GAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCT

AA

[0142] SEQ ID NO: 97

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGAACTA

ATAACTTCCAGAATTTCATTGGTATCTCCTCTTTACAAAAAACTCTAAGAAACGCCC

TAATTCCGACTGAAACTACACAGCAATTCATCGTCAAAAACGGGATCATTAAGGAG

GATGAGTTGAGGGGTGAAAATCGTCAAATTCTTAAAGACATCATGGACGACTACTA

CAGGGGGTTCATCAGCGAGACGTTATCTAGTATAGACGATATAGACTGGACTTCACT

GTTCGAGAAGATGGAAATCCAATTAAAAAATGGGGACAATAAAGATACACTTATAA

AGGAACAGACAGAGTATAGAAAGGCAATACACAAAAAGTTTGCCAACGACGATCGT

TTCAAGAACATGTTTAGTGCTAAATTGATTTCAGATATTCTGCCGGAATTTGTTATT C

ACAACAATAATTATAGCGCCAGTGAGAAAGAAGAAAAAACGCAGGTTATCAAACTG

TTCAGTCGTTTCGCTACATCTTTTAAGGATTACTTTAAAAACCGTGCAAATTGTTTT T

CAGCCGACGATATTAGTAGCAGCTCTTGTCACCGTATTGTTAATGATAATGCGGAGA

TTTTCTTTTCAAACGCATTGGTCTACAGGAGGATAGTCAAGTCCCTTTCAAATGACG

ACATTAATAAGATCTCAGGTGACATGAAAGATTCCTTAAAGGAAATGTCCCTGGAA

GAGATCTATTCCTATGAAAAGTACGGTGAGTTCATTACTCAAGAGGGTATAAGCTTT

TACAATGACATATGTGGTAAGGTTAATAGCTTTATGAACCTGTATTGCCAGAAGAAC

AAAGAAAATAAGAATCTGTATAAGTTGCAAAAGCTACACAAACAAATTTTGTGCAT

TGCCGATACATCATACGAGGTGCCATACAAATTCGAGAGCGATGAGGAGGTTTATC

AGAGCGTGAATGGATTCCTGGACAATATTAGTAGTAAGCATATCGTGGAAAGGCTT

AGAAAGATAGGTGACAATTACAATGGCTACAATCTGGATAAAATCTACATCGTCTC

AAAATTCTATGAAAGTGTATCCCAGAAGACGTACCGTGATTGGGAAACTATCAACA CCGCTCTGGAGATACATTACAACAATATACTTCCCGGAAACGGCAAGTCAAAAGCC

GACAAAGTCAAAAAAGCGGTCAAGAACGATTTACAAAAGTCTATCACTGAAATTAA

TGAATTAGTTAGTAATTACAAACTGTGTAGTGATGATAATATTAAGGCAGAGACTTA

CATACACGAAATTTCACACATTTTAAACAACTTCGAGGCACAGGAACTTAAATATAA

TCCTGAAATTCACCTGGTTGAAAGTGAATTGAAAGCCAGCGAGCTAAAGAACGTTTT

GGACGTAATCATGAACGCATTCCACTGGTGCTCTGTCTTTATGACAGAGGAACTAGT

GGATAAGGACAATAATTTTTATGCGGAGCTGGAGGAAATATACGATGAGATATATC

CCGTAATATCATTATATAATCTGGTAAGAAACTATGTGACTCAAAAGCCGTATAGCA

CCAAGAAAATTAAACTTAATTTCGGCATACCCACTTTAGCGGACGGCTGGTCAAAAT

CCAAAGAGTATAGTAATAATGCCATCATCCTGATGCGTGACAACCTGTACTATTTAG

GTATATTTAACGCCAAAAATAAACCCGACAAAAAGATTATAGAGGGCAACACCTCA

GAGAACAAAGGTGATTATAAGAAGATGATTTACAACCTTTTACCCGGTCCTAATAAG

ATGATTCCCAAAGTCTTTCTATCTAGCAAAACTGGTGTTGAAACATACAAACCCTCA

GCTTATATTTTAGAAGGGTATAAGCAGAATAAGCATATTAAAAGCTCCAAAGATTTC

GATATTACCTTTTGCCATGACTTGATAGACTATTTCAAAAATTGTATTGCCATTCAC C

CTGAATGGAAAAACTTCGGATTTGACTTCTCTGACACATCCACCTACGAAGACATTT

CAGGTTTTTACAGGGAAGTCGAGCTACAGGGTTATAAAATTGATTGGACATACATCA

GCGAGAAAGATATTGACCTACTTCAAGAAAAAGGGCAGCTATACCTGTTCCAGATA

TACAATAAAGACTTCAGTAAAAAAAGCACCGGGAACGATAATCTTCACACAATGTA

CTTAAAAAATTTATTTAGTGAAGAGAATCTGAAGGATATAGTGCTGAAGTTAAACG

GGGAGGCAGAGATATTTTTTAGAAAATCTAGTATTAAGAATCCGATCATCCACAAG

AAGGGTTCTATCCTTGTTAATAGGACTTATGAGGCAGAAGAAAAAGACCAATTCGG

CAACATACAAATTGTCCGTAAAAATATCCCTGAGAACATTTATCAGGAACTATACAA

GTACTTCAATGATAAAAGCGACAAGGAGCTGAGCGACGAGGCTGCTAAGTTAAAGA

ATGTGGTGGGCCACCATGAGGCAGCAACGAATATTGTGAAGGACTATCGTTATACCT

ACGATAAATACTTTCTTCATATGCCGATCACCATTAATTTCAAGGCAAACAAAACTG

GCTTCATTAACGATCGTATCTTACAATATATCGCAAAAGAGAAAGACCTTCACGTTA

TCGGGATCGATAGAGGCGAGCGTAACCTAATTTATGTTTCTGTGATAGACACCTGTG

GGAACATAGTCGAACAGAAATCATTTAATATTGTTAACGGCTACGATTATCAGATAA

AGTTGAAGCAACAAGAGGGTGCACGTCAAATAGCAAGGAAAGAATGGAAAGAAAT

AGGCAAGATTAAAGAAATAAAAGAAGGTTATTTATCCCTTGTAATACACGAAATTA

GCAAAATGGTGATTAAATATAATGCGATCATTGCCATGGAGGATCTTTCTTACGGCT

TCAAAAAGGGGAGATTCAAAGTCGAGAGGCAGGTGTATCAGAAGTTTGAGACCATG

CTAATCAATAAACTAAATTATCTAGTATTCAAAGACATAAGCATCACCGAAAATGGC

GGCTTGTTGAAGGGTTATCAATTGACCTACATCCCAGATAAACTAAAAAACGTAGG GCATCAATGCGGATGTATATTTTACGTTCCAGCCGCATACACTTCCAAAATCGATCC

AACTACGGGTTTTGTGAACATCTTCAAATTCAAAGACTTGACTGTCGATGCTAAGAG

GGAGTTTATCAAGAAATTTGACTCCATTAGATACGACAGTGAGAAGAATCTGTTCTG

TTTTACCTTTGATTATAACAACTTTATAACTCAAAACACAGTCATGAGTAAGTCATC T

TGGTCAGTGTATACGTATGGTGTGAGGATTAAAAGGAGGTTTGTTAACGGGAGATTT

TCCAATGAAAGTGATACAATAGATATAACCAAGGACATGGAAAAGACTCTTGAAAT

GACCGACATTAACTGGAGAGATGGCCACGACTTACGTCAAGATATAATCGATTACG

AGATAGTGCAACATATCTTTGAGATATTTAGGCTTACTGTCCAAATGCGTAACTCAT

TAAGTGAGTTGGAGGACAGGGATTACGATAGGCTAATAAGTCCTGTTCTTAACGAA

AACAATATATTCTACGATTCAGCAAAGGCGGGAGACGCCCTGCCCAAGGACGCGGA

TGCTAACGGCGCATACTGTATTGCCCTGAAAGGCTTGTACGAGATAAAACAGATCAC

GGAGAACTGGAAAGAAGATGGAAAATTCAGTCGTGACAAGTTAAAAATTAGTAACA

AAGACTGGTTCGACTTTATTCAGAACAAGAGATATCTGAAACGTCCGGCAGCGACC

AAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCC

CGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGG

CTAA

[0143] SEQ ID NO: 98

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAACGGAACCA

ATAACTTTCAAAACTTTATAGGCATCTCCAGTCTACAGAAGACACTACGTAACGCTT

TGATACCAACTGAGACCACGCAGCAGTTTATCGTCAAGAACGGTATTATAAAGGAA

GACGAGCTAAGGGGGGAAAACCGTCAGATCTTAAAGGACATCATGGATGACTACTA

CAGAGGCTTCATAAGTGAGACTTTGTCTAGTATAGACGACATCGACTGGACCAGTTT

ATTTGAGAAGATGGAAATTCAGTTAAAGAACGGGGACAATAAAGACACACTAATTA

AAGAGCAGACCGAATACAGAAAAGCTATACACAAAAAGTTTGCCAACGATGATAGA

TTCAAAAATATGTTTTCAGCAAAATTGATTTCCGACATATTGCCAGAATTCGTAATC

CATAATAACAATTATTCTGCAAGTGAGAAGGAAGAGAAGACCCAAGTAATCAAGCT

GTTTTCCCGTTTTGCTACGAGTTTCAAAGATTATTTCAAGAATAGGGCTAATTGTTT C

TCCGCGGACGACATAAGTAGCAGTTCCTGTCACAGGATTGTGAACGATAATGCTGA

GATATTTTTTTCCAATGCCCTAGTGTATAGGAGAATAGTTAAAAGCTTAAGCAACGA

CGATATCAATAAAATTTCAGGGGACATGAAGGACAGCTTAAAGGAAATGAGTTTGG

AGGAGATTTACAGTTATGAAAAATACGGAGAGTTTATAACTCAGGAAGGCATCTCTT

TCTATAATGATATCTGTGGGAAGGTAAACTCCTTCATGAATTTATATTGCCAGAAGA

ATAAGGAAAACAAAAATCTTTACAAGCTTCAAAAGTTACATAAGCAGATCTTATGT

ATTGCCGACACGAGTTATGAAGTGCCTTATAAATTCGAGAGTGATGAGGAAGTGTAT

CAGTCTGTTAACGGATTCCTAGATAATATAAGTTCCAAACATATAGTCGAGAGGCTG AGGAAGATTGGCGATAACTATAATGGATATAATCTTGACAAAATCTATATAGTCTCT

AAATTTTATGAAAGCGTCAGCCAGAAGACATATAGAGATTGGGAAACTATAAACAC

AGCCCTTGAAATACATTACAATAACATCCTACCCGGCAATGGTAAGTCTAAGGCAG

ACAAAGTTAAAAAAGCAGTAAAGAATGACTTACAGAAGTCAATCACGGAGATAAAT

GAGTTGGTCAGTAACTACAAATTATGCTCCGACGATAATATTAAGGCCGAAACATAT

ATACACGAGATAAGTCATATATTAAACAATTTCGAAGCCCAGGAGTTAAAATATAA

CCCTGAAATTCATCTGGTCGAAAGTGAGTTAAAGGCCAGTGAGTTAAAGAATGTACT

TGACGTAATTATGAATGCTTTTCATTGGTGCTCCGTGTTCATGACCGAGGAGTTAGT

AGATAAAGACAATAACTTTTACGCCGAACTTGAAGAGATATACGACGAGATTTATC

CGGTAATCAGCTTGTACAACTTAGTTAGAAATTATGTAACACAGAAGCCTTACTCTA

CTAAAAAAATAAAACTGAACTTTGGTATCCCAACTCTTGCAGATGGTTGGAGTAAAA

GCAAGGAATATAGCAACAATGCGATCATCTTGATGAGAGACAACTTGTACTATTTGG

GAATCTTCAACGCGAAAAATAAACCCGACAAAAAAATCATCGAAGGGAATACCTCT

GAGAATAAAGGTGACTATAAGAAAATGATTTACAATCTACTTCCTGGTCCTAATAAA

ATGATCCCGAAAGTGTTTCTTAGTTCTAAGACTGGTGTCGAGACGTACAAACCTAGC

GCGTACATCTTAGAAGGGTACAAGCAGAATAAACACATCAAATCAAGCAAAGACTT

CGATATTACTTTTTGCCATGACTTGATAGACTACTTTAAAAACTGCATAGCAATCCA

CCCGGAGTGGAAAAACTTTGGCTTTGATTTCTCTGACACCTCTACATATGAGGACAT

ATCTGGTTTTTACCGTGAGGTTGAATTGCAGGGATACAAAATTGACTGGACTTACAT

ATCTGAAAAAGATATCGATCTATTGCAGGAGAAAGGCCAGCTTTACCTTTTCCAGAT

CTATAATAAGGACTTCTCTAAGAAGTCTACAGGGAATGATAATTTGCACACTATGTA

CTTAAAAAATCTGTTTTCCGAGGAAAACTTGAAAGACATTGTTTTAAAGTTGAACGG

AGAAGCTGAAATATTTTTCAGAAAGAGCTCCATAAAAAACCCGATCATTCATAAGA

AGGGATCTATCCTGGTTAACAGAACGTACGAAGCGGAAGAAAAAGACCAATTCGGA

AACATTCAAATTGTTAGAAAGAATATCCCTGAGAACATCTACCAGGAGTTATATAAG

TATTTTAATGATAAGTCAGATAAGGAACTATCTGACGAAGCGGCGAAGCTTAAAAA

TGTTGTAGGACACCATGAGGCTGCTACAAATATAGTCAAGGACTACCGTTATACCTA

CGATAAGTACTTTCTACACATGCCCATTACCATCAATTTTAAAGCTAATAAAACGGG

TTTTATCAACGATCGTATCCTACAATATATTGCGAAAGAGAAGGATTTGCATGTCAT

TGGCATTGATAGAGGTGAGAGGAACCTAATATACGTATCCGTGATTGATACGTGCG

GGAACATAGTTGAACAGAAATCATTTAATATAGTTAATGGGTACGACTATCAGATTA

AGCTAAAGCAACAAGAAGGCGCCAGGCAAATTGCCCGTAAAGAATGGAAAGAGAT

CGGGAAGATCAAGGAAATAAAAGAAGGATACCTTTCCCTGGTCATCCATGAAATTA

GCAAAATGGTGATTAAGTACAATGCCATAATCGCGATGGAGGACTTAAGCTACGGG

TTCAAAAAGGGGAGGTTTAAGGTGGAGAGGCAAGTGTACCAGAAATTTGAGACCAT GCTAATCAACAAACTGAACTACCTAGTTTTTAAGGACATTTCAATTACAGAGAATGG

AGGACTTTTAAAGGGTTACCAACTAACGTATATACCAGATAAGTTGAAAAATGTCG

GTCACCAGTGTGGCTGCATCTTTTACGTTCCCGCCGCTTATACATCTAAAATTGATC C

AACCACAGGCTTTGTAAATATCTTTAAATTCAAAGATTTAACTGTGGATGCAAAAAG

AGAGTTTATCAAGAAATTCGATAGCATTCGTTATGATAGCGAGAAGAACCTGTTCTG

CTTTACTTTCGACTATAACAACTTTATAACTCAAAACACCGTGATGTCAAAAAGCTC

ATGGTCAGTCTACACCTATGGTGTAAGGATTAAAAGGCGTTTCGTGAATGGGAGATT

CTCCAATGAAAGTGACACGATCGACATAACAAAGGACATGGAGAAGACACTAGAG

ATGACTGATATTAATTGGAGAGACGGACACGATCTGCGTCAAGATATAATTGATTAT

GAGATAGTACAGCACATATTTGAGATCTTCCGTTTGACTGTCCAAATGCGTAATTCC

CTTTCTGAGCTGGAAGATAGGGACTATGATAGATTAATATCCCCTGTACTAAATGAG

AACAACATTTTCTATGATAGTGCAAAAGCCGGGGATGCATTGCCGAAAGACGCTGA

CGCTAATGGGGCGTACTGTATAGCTTTAAAGGGGCTTTACGAAATAAAGCAGATAA

CCGAAAACTGGAAGGAAGATGGCAAATTCTCAAGGGACAAACTTAAGATCTCTAAC

AAGGATTGGTTCGATTTTATACAAAACAAACGTTATTTGAAACGTCCGGCAGCGACC

AAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCC

CGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGG

CTAA

[0144] SEQ ID NO: 99

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGTACAAA

CAACTTTCAGAATTTCATTGGGATCTCTAGCTTACAGAAGACCCTGAGGAATGCGTT

GATTCCAACTGAAACAACCCAGCAATTCATCGTGAAAAATGGGATAATCAAAGAGG

ATGAGTTAAGGGGTGAAAACCGTCAAATATTGAAGGATATTATGGACGACTACTAC

CGTGGATTCATCTCAGAGACGTTGAGCAGCATTGACGACATAGACTGGACTAGCCTT

TTCGAGAAGATGGAAATTCAGTTAAAGAACGGAGATAACAAAGATACACTAATCAA

GGAACAGACAGAATACAGAAAAGCAATTCATAAGAAATTCGCTAATGACGATCGTT

TTAAAAACATGTTCTCTGCAAAATTAATTAGCGACATTCTGCCGGAATTCGTTATAC

ATAATAATAACTACAGTGCTTCTGAAAAGGAAGAGAAAACTCAGGTAATAAAACTG

TTCTCTCGTTTTGCCACATCCTTCAAAGACTACTTTAAAAATAGAGCGAACTGCTTT A

GCGCCGACGATATTAGTTCTTCCTCATGCCACAGGATTGTCAACGATAATGCAGAGA

TATTCTTTTCTAACGCACTAGTCTACAGAAGGATTGTAAAGTCTTTGTCAAATGATG

ACATAAACAAGATTAGTGGAGATATGAAAGACTCTCTAAAGGAAATGAGCCTTGAG

GAGATATACTCTTATGAAAAGTACGGTGAGTTTATTACCCAAGAAGGCATTAGTTTC

TATAATGACATTTGTGGAAAAGTTAACAGTTTTATGAATCTATACTGTCAAAAAAAT

AAGGAGAATAAAAATCTTTATAAGTTGCAAAAACTGCATAAGCAGATATTATGTAT AGCAGACACGAGCTATGAGGTACCGTACAAGTTCGAGAGCGATGAGGAAGTCTACC

AATCTGTCAACGGATTTTTGGACAACATTTCTTCAAAACATATTGTGGAGAGGCTTA

GGAAAATAGGCGACAATTATAATGGATATAACTTAGATAAGATATATATTGTTTCCA

AATTCTACGAATCTGTAAGCCAGAAGACATACAGAGATTGGGAAACGATAAACACA

GCCCTTGAAATTCACTATAACAACATACTACCTGGAAACGGCAAATCAAAGGCCGA

CAAAGTTAAGAAGGCCGTAAAGAATGATTTACAGAAGAGCATAACGGAGATCAATG

AGCTGGTGTCTAACTATAAATTGTGTAGCGATGACAACATAAAAGCCGAGACTTAC

ATTCACGAAATTTCACACATACTTAACAACTTTGAAGCTCAGGAATTAAAGTATAAT

CCCGAAATACACCTTGTGGAGTCCGAACTAAAGGCTAGTGAGCTTAAGAACGTCCT

AGACGTAATTATGAATGCCTTCCACTGGTGTAGTGTTTTTATGACCGAGGAACTTGT

TGACAAAGATAATAATTTTTATGCAGAACTAGAAGAGATATACGATGAAATATACC

CGGTGATCAGTTTGTACAATCTTGTCAGGAACTATGTGACACAAAAGCCCTATTCAA

CAAAGAAAATAAAACTTAATTTCGGAATTCCTACGTTAGCTGATGGCTGGTCTAAAT

CCAAGGAATACAGCAACAACGCTATAATTCTGATGAGAGATAACTTGTACTATCTAG

GCATCTTCAATGCCAAAAATAAGCCTGATAAGAAGATTATAGAGGGCAACACTTCA

GAGAACAAGGGCGACTACAAGAAAATGATCTATAACCTATTGCCTGGCCCAAACAA

GATGATTCCGAAGGTCTTCCTATCATCCAAGACCGGCGTTGAGACATACAAGCCATC

AGCGTATATTTTAGAGGGGTACAAACAAAACAAGCACATAAAGTCTAGTAAAGACT

TCGATATAACATTTTGTCATGACTTAATTGACTACTTTAAGAATTGCATCGCTATAC A

CCCGGAATGGAAGAATTTCGGCTTCGACTTCTCTGATACATCTACCTACGAGGACAT

TAGCGGGTTTTACCGTGAAGTCGAATTACAAGGGTATAAGATAGATTGGACGTACAT

CTCTGAGAAAGACATAGACTTGCTTCAGGAAAAGGGCCAGTTGTATCTATTCCAAAT

ATACAATAAGGATTTTTCCAAGAAATCTACGGGTAATGACAATCTTCACACAATGTA

TCTTAAGAACCTTTTCTCAGAAGAGAACCTGAAGGACATTGTCTTAAAACTAAATGG

CGAAGCTGAGATTTTTTTCAGGAAGTCTTCAATTAAGAACCCGATAATCCACAAGAA

GGGGAGTATTCTTGTGAATAGAACTTACGAGGCCGAAGAAAAAGACCAATTTGGTA

ACATCCAGATAGTCAGAAAGAACATTCCAGAGAACATCTACCAAGAGCTATACAAA

TATTTCAACGACAAGTCCGATAAGGAACTGTCCGATGAGGCAGCCAAGTTGAAGAA

TGTCGTGGGTCATCATGAAGCTGCTACTAACATTGTCAAGGACTATCGTTATACTTA

CGACAAGTATTTCCTACACATGCCGATAACAATTAATTTCAAGGCTAACAAAACAGG

CTTTATCAACGATCGTATCTTGCAGTACATAGCTAAGGAAAAGGATTTGCATGTGAT

TGGCATTGATAGAGGGGAGCGTAACTTGATATATGTGTCTGTCATAGACACGTGTGG

CAACATCGTCGAACAGAAATCATTCAACATAGTAAACGGCTACGATTACCAAATTA

AGCTGAAACAGCAAGAGGGTGCACGTCAAATTGCGCGTAAAGAGTGGAAAGAAATT

GGTAAAATCAAGGAAATTAAAGAAGGCTACTTGTCTCTTGTTATACATGAAATTTCC AAGATGGTTATAAAGTATAACGCGATAATTGCTATGGAAGACTTATCATACGGGTTT

AAAAAGGGGAGGTTCAAGGTAGAGAGGCAGGTCTATCAAAAGTTCGAGACGATGTT

GATTAATAAACTAAACTATCTAGTGTTCAAAGATATCAGCATTACGGAGAACGGGG

GGCTACTGAAAGGATATCAACTAACGTACATTCCCGATAAGTTAAAGAACGTTGGTC

ATCAATGTGGTTGCATCTTCTACGTGCCTGCTGCCTATACGTCCAAAATAGATCCAA

CTACTGGATTTGTTAACATCTTTAAATTCAAAGATTTAACCGTAGACGCCAAAAGGG

AATTTATAAAAAAATTTGACAGCATCCGTTACGATAGCGAAAAGAATCTGTTCTGTT

TTACTTTCGACTACAATAATTTCATCACGCAAAATACGGTAATGTCTAAGTCAAGTT

GGAGCGTCTACACGTATGGAGTCAGGATCAAGAGGCGTTTCGTAAATGGAAGATTC

TCTAATGAGTCAGATACTATAGACATCACGAAAGATATGGAGAAAACCTTGGAGAT

GACGGATATTAACTGGCGTGATGGACACGATTTAAGACAGGACATTATTGACTATG

AGATTGTGCAACACATCTTCGAAATATTCCGTCTAACAGTCCAAATGAGGAATAGCC

TAAGTGAATTGGAGGACCGTGATTACGATAGGCTTATAAGTCCTGTCCTTAACGAAA

ACAATATTTTCTATGATAGTGCTAAGGCGGGGGACGCACTGCCTAAAGACGCAGAT

GCTAACGGGGCATACTGCATTGCGTTAAAGGGTCTGTACGAAATCAAGCAGATTAC

GGAAAACTGGAAAGAGGATGGCAAGTTTAGCAGAGATAAGTTGAAGATAAGTAAC

AAAGATTGGTTTGACTTTATTCAGAATAAAAGGTATTTAAAACGTCCGGCAGCGACC

AAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCC

CGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGG

CTAA

[0145] SEQ ID NO: 100

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGCACTAA

TAATTTCCAGAATTTCATCGGCATTAGCAGCTTACAAAAGACGTTGAGGAATGCCTT

AATACCCACAGAAACTACTCAACAATTTATAGTGAAGAATGGGATAATTAAGGAAG

ACGAGTTGAGAGGTGAAAATAGGCAAATCTTGAAAGACATTATGGATGACTACTAC

AGGGGCTTCATTAGTGAAACGTTGTCTTCAATAGATGACATTGATTGGACTTCTTTG T

TTGAGAAGATGGAAATACAGTTAAAGAACGGCGACAATAAGGATACACTTATCAAA

GAGCAAACAGAATATAGAAAAGCAATTCACAAAAAGTTTGCTAACGATGATAGGTT

CAAGAACATGTTTAGCGCTAAACTAATATCAGACATCCTTCCCGAGTTCGTTATTCA

TAACAATAACTATAGTGCAAGTGAAAAAGAGGAGAAGACACAGGTGATTAAGCTGT

TCTCCAGATTCGCGACTTCTTTCAAAGATTACTTCAAAAACAGAGCCAACTGTTTTT C

AGCTGACGATATCTCTAGTAGTAGTTGTCACCGTATAGTGAACGATAACGCTGAGAT

CTTCTTTAGCAATGCATTAGTGTATAGAAGGATAGTTAAGTCTCTAAGCAATGATGA

TATCAATAAAATTTCCGGAGACATGAAGGACTCCCTAAAGGAAATGTCCTTAGAAG

AGATCTACTCATATGAGAAATACGGGGAATTTATTACGCAGGAAGGGATCTCCTTTT ACAATGACATATGCGGGAAGGTCAACTCTTTCATGAACTTATACTGCCAAAAGAAC

AAGGAGAACAAGAATTTATATAAACTTCAGAAACTTCACAAACAAATACTGTGCAT

AGCCGATACCTCATATGAGGTTCCTTACAAATTTGAATCAGATGAAGAGGTATACCA

ATCCGTTAACGGCTTTCTTGACAATATTAGCTCAAAGCACATCGTGGAGAGGTTGAG

AAAGATTGGTGATAATTATAATGGCTACAATCTAGATAAGATATATATTGTTAGCAA

GTTCTACGAGTCTGTGTCCCAAAAAACATATAGGGATTGGGAGACAATTAATACTGC

TCTAGAAATCCATTACAACAACATCCTTCCTGGAAATGGCAAGAGTAAGGCCGACA

AAGTCAAGAAAGCAGTGAAAAATGATCTGCAAAAATCAATTACTGAGATAAACGAG

CTAGTATCTAATTACAAGCTTTGTAGCGACGATAACATTAAGGCAGAAACGTACATA

CACGAGATTAGTCACATCTTAAATAATTTTGAAGCCCAAGAACTGAAATATAACCCT

GAGATACACCTTGTTGAATCCGAGTTAAAGGCGTCTGAACTAAAAAACGTGTTAGA

CGTTATTATGAATGCCTTCCACTGGTGTAGCGTCTTTATGACTGAGGAGTTGGTTGA T

AAGGATAATAACTTTTACGCTGAATTGGAAGAAATTTATGACGAAATCTATCCTGTT

ATTTCTCTATATAATTTGGTGAGAAATTACGTAACGCAAAAGCCCTATAGTACGAAA

AAAATAAAACTAAATTTCGGGATCCCTACCCTAGCCGACGGTTGGTCTAAATCCAAG

GAGTACTCAAACAATGCAATAATATTGATGAGGGACAACCTGTACTACCTAGGCAT

ATTTAATGCCAAAAATAAGCCCGATAAAAAGATTATAGAAGGGAACACGTCAGAAA

ATAAAGGAGACTATAAGAAAATGATCTACAACCTTTTGCCCGGCCCCAATAAAATG

ATCCCGAAGGTCTTCCTAAGTAGCAAGACTGGCGTAGAGACCTACAAACCATCTGC

ATACATTTTGGAGGGGTACAAGCAAAACAAGCACATAAAGAGTAGTAAGGATTTTG

ACATTACATTCTGCCATGACTTAATTGACTACTTTAAAAATTGCATCGCAATTCACC C

TGAATGGAAAAATTTTGGATTTGATTTCTCTGATACTTCAACATATGAGGATATTTC A

GGGTTCTACAGGGAGGTCGAACTACAGGGTTACAAAATAGACTGGACGTATATTTCT

GAGAAAGATATAGATTTGCTTCAGGAAAAGGGTCAGCTATATCTGTTCCAGATATAT

AATAAGGACTTCTCCAAAAAGAGTACCGGAAATGATAATCTGCACACAATGTACTT

AAAAAACTTGTTCTCTGAGGAGAATCTAAAAGACATCGTACTAAAACTTAACGGGG

AGGCCGAAATTTTTTTTAGGAAGTCCAGCATCAAGAACCCGATTATTCATAAAAAAG

GTAGCATTTTGGTGAACCGTACTTATGAGGCGGAAGAAAAAGACCAATTCGGTAAT

ATTCAAATCGTTAGAAAGAACATCCCTGAGAACATTTATCAGGAACTATACAAATAC

TTTAACGACAAATCAGATAAGGAGCTTTCTGATGAGGCAGCTAAATTGAAAAATGT

AGTGGGACATCACGAAGCAGCCACTAACATAGTGAAGGACTACAGATACACATACG

ATAAGTACTTCCTGCACATGCCTATTACAATTAACTTTAAAGCAAATAAAACAGGGT

TTATTAACGACAGAATCTTACAGTATATTGCCAAAGAAAAGGATCTGCATGTGATAG

GAATAGACAGAGGAGAAAGAAACCTGATATACGTCTCCGTGATTGATACATGTGGG

AACATAGTAGAACAGAAGTCCTTTAACATTGTTAATGGGTACGATTATCAAATTAAA TTAAAACAACAAGAAGGAGCACGTCAAATAGCTAGGAAAGAATGGAAAGAGATAG

GAAAAATTAAGGAAATTAAGGAGGGTTACCTGTCCCTTGTAATTCATGAAATATCCA

AAATGGTAATTAAATATAACGCGATCATCGCGATGGAAGATCTAAGCTACGGGTTC

AAAAAAGGCAGGTTTAAGGTGGAGAGGCAAGTTTACCAAAAGTTCGAGACAATGTT

GATTAATAAGTTAAACTACTTAGTTTTCAAAGATATCTCCATAACCGAGAATGGCGG

GCTTTTAAAAGGGTACCAACTAACATATATCCCGGATAAATTGAAGAACGTTGGAC

ACCAGTGTGGCTGCATATTTTATGTACCCGCTGCGTATACTTCTAAAATTGACCCGA

CCACCGGGTTTGTAAACATATTCAAGTTTAAGGACCTAACAGTTGACGCCAAACGTG

AGTTCATCAAGAAGTTCGATAGTATAAGGTATGACTCTGAGAAGAACCTTTTCTGCT

TCACGTTTGACTATAATAATTTCATCACCCAAAATACAGTTATGTCAAAAAGCTCTT

GGTCAGTATATACGTATGGCGTAAGGATTAAGCGTAGGTTCGTGAACGGTAGATTTT

CCAACGAGTCAGATACTATTGATATTACCAAGGATATGGAGAAGACATTAGAAATG

ACAGATATAAATTGGAGGGATGGGCACGATCTAAGGCAAGATATCATTGATTACGA

AATTGTTCAGCACATATTCGAGATATTCCGTCTTACAGTACAAATGCGTAACAGCTT

GTCTGAGTTGGAAGATCGTGACTATGACAGGTTGATATCACCGGTCTTGAACGAGAA

CAATATATTCTACGACAGCGCTAAGGCGGGAGACGCTCTGCCTAAAGACGCAGATG

CCAATGGGGCGTACTGCATTGCCTTAAAAGGCTTATACGAGATTAAACAGATCACA

GAGAACTGGAAAGAGGACGGCAAGTTTTCTAGAGATAAATTGAAAATCTCAAACAA

AGACTGGTTCGATTTCATCCAAAACAAAAGATACCTTAAACGTCCGGCAGCGACCA

AAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCC

GAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCT

AA

[0146] SEQ ID NO: 101

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGAACTA

ACAACTTCCAGAACTTTATCGGCATCTCTTCCCTCCAAAAGACACTGAGAAATGCAC

TGATCCCAACCGAAACGACTCAACAATTTATTGTTAAGAACGGCATCATAAAAGAA

GACGAGCTTCGCGGCGAGAACCGCCAGATACTTAAGGATATTATGGACGATTATTA

CCGAGGCTTTATCAGCGAAACTCTTAGCTCTATTGATGATATCGACTGGACCTCCCT

CTTCGAAAAAATGGAGATACAGCTCAAGAACGGCGATAATAAAGACACCTTGATAA

AGGAACAGACTGAGTACAGGAAAGCGATCCACAAGAAATTCGCGAACGACGACAG

GTTTAAAAACATGTTCTCTGCAAAATTGATATCCGACATCTTGCCGGAATTTGTGAT

ACACAACAATAACTATAGCGCTTCAGAGAAAGAAGAGAAGACCCAAGTAATCAAGT

TGTTCAGCCGCTTCGCAACGTCTTTTAAAGATTACTTTAAGAACCGGGCCAATTGTT T

CTCCGCGGATGATATTAGCTCATCAAGTTGCCATCGAATTGTCAATGATAATGCGGA

GATCTTCTTCAGCAATGCGCTGGTCTACAGACGAATCGTAAAAAGTCTTTCAAATGA CGACATCAATAAGATTAGTGGAGATATGAAGGATTCCCTTAAGGAAATGAGTCTTG

AAGAAATATACTCATACGAAAAGTACGGGGAATTTATTACCCAGGAGGGGATCTCC

TTCTATAACGACATCTGTGGAAAAGTAAACTCATTCATGAACCTGTACTGTCAGAAA

AACAAAGAAAACAAAAATCTGTATAAACTCCAAAAATTGCACAAGCAAATATTGTG

TATAGCGGACACATCATACGAGGTTCCATATAAGTTCGAAAGTGATGAAGAAGTCT

ACCAATCAGTGAATGGGTTTCTGGACAACATTAGTTCCAAGCACATAGTTGAACGAC

TGCGAAAGATTGGTGACAATTACAACGGCTATAATTTGGACAAGATTTATATAGTTA

GCAAATTTTATGAATCCGTATCACAAAAGACTTATAGAGACTGGGAAACAATCAAC

ACGGCACTTGAGATCCATTATAACAATATTCTTCCAGGGAACGGCAAAAGCAAGGC

TGATAAGGTAAAAAAGGCCGTTAAGAATGATCTTCAAAAATCCATAACGGAGATCA

ACGAACTTGTAAGTAACTACAAATTGTGCTCTGACGACAATATAAAGGCTGAAACG

TATATTCACGAGATTAGCCATATCCTGAATAACTTTGAGGCCCAAGAACTCAAGTAT

AACCCGGAAATACATTTGGTAGAAAGCGAGCTTAAAGCGAGTGAGCTGAAAAACGT

CCTCGATGTGATCATGAATGCTTTCCACTGGTGTAGTGTCTTTATGACTGAGGAGTT G

GTTGATAAAGACAATAATTTCTACGCTGAACTGGAAGAAATTTACGACGAAATCTAT

CCAGTGATCTCCCTCTATAACCTCGTTCGAAACTACGTGACGCAGAAACCTTATTCT

ACAAAGAAAATTAAGTTGAACTTCGGCATTCCTACACTTGCTGACGGATGGTCCAAA

TCCAAAGAGTACTCAAACAACGCAATCATCCTCATGCGGGATAACCTTTATTATTTG

GGCATTTTCAACGCCAAAAACAAACCTGATAAAAAGATAATTGAAGGCAATACGAG

TGAGAACAAGGGCGACTACAAAAAAATGATATATAACTTGTTGCCAGGCCCCAACA

AGATGATTCCTAAAGTTTTTCTGTCTTCTAAGACTGGAGTTGAAACTTACAAACCCT C

CGCCTACATTCTTGAAGGGTATAAACAGAATAAGCACATAAAGTCCTCAAAGGATTT

CGACATTACGTTTTGCCATGACCTCATCGACTATTTCAAGAACTGTATCGCCATACA T

CCGGAGTGGAAGAATTTTGGATTTGATTTCTCCGACACATCTACCTATGAAGACATA

AGCGGTTTCTACCGGGAGGTCGAGCTTCAGGGCTATAAGATAGATTGGACATACATT

AGTGAAAAAGATATCGATCTTCTGCAAGAAAAGGGACAACTTTACCTTTTTCAGATT

TATAATAAAGACTTTTCAAAAAAGTCCACAGGGAACGATAATCTGCACACCATGTAT

CTCAAGAATCTGTTTAGTGAAGAAAACCTTAAAGACATAGTTTTGAAGCTTAACGGA

GAGGCTGAGATTTTTTTTAGAAAGTCCTCAATTAAAAACCCTATAATACACAAGAAA

GGCTCTATTCTTGTTAACAGGACATATGAAGCCGAGGAGAAAGATCAGTTTGGCAAT

ATCCAGATTGTTCGCAAGAATATCCCGGAAAATATATATCAGGAGCTGTATAAATAC

TTTAACGACAAGAGCGACAAGGAGCTGAGTGACGAGGCCGCGAAGCTTAAGAATGT

AGTAGGTCACCACGAAGCAGCCACCAATATCGTCAAAGACTATAGGTACACGTACG

ACAAGTACTTTTTGCACATGCCTATAACTATAAACTTCAAAGCTAATAAAACTGGGT

TTATTAATGACAGGATTCTCCAATACATCGCTAAAGAGAAGGATCTGCATGTAATTG GCATAGACAGAGGTGAGAGAAACTTGATATATGTCAGCGTAATAGACACATGTGGC

AATATCGTGGAACAGAAGTCTTTTAACATCGTCAATGGTTACGACTACCAAATTAAG

TTGAAACAGCAGGAAGGCGCACGACAGATCGCACGAAAGGAATGGAAAGAGATAG

GCAAAATAAAAGAAATAAAGGAGGGCTATCTCAGTCTCGTTATACACGAAATTTCA

AAAATGGTTATTAAGTACAATGCAATCATAGCGATGGAGGATCTCAGTTATGGGTTC

AAAAAGGGTCGGTTTAAAGTTGAGCGCCAAGTGTACCAAAAGTTCGAGACAATGCT

GATTAACAAGCTGAACTACCTCGTCTTCAAAGATATAAGTATTACGGAGAACGGTG

GCCTTCTTAAAGGCTATCAACTTACTTACATCCCGGACAAGCTCAAAAACGTAGGGC

ACCAATGCGGGTGTATTTTCTATGTGCCTGCGGCATATACGTCAAAGATTGACCCAA

CCACAGGATTCGTAAACATATTCAAGTTTAAGGACCTCACCGTTGATGCGAAAAGG

GAGTTCATTAAAAAATTTGATTCTATTCGATATGATAGTGAGAAAAATCTCTTTTGT T

TCACATTTGACTATAATAATTTTATTACTCAGAATACTGTCATGAGCAAGTCATCTT G

GTCAGTGTACACATACGGGGTGCGGATCAAACGCAGGTTCGTCAATGGTCGCTTCTC

AAACGAATCAGACACCATTGACATCACAAAGGACATGGAAAAAACCCTTGAGATGA

CCGACATTAATTGGCGCGATGGTCATGATCTGCGGCAAGACATCATAGACTACGAA

ATCGTCCAACACATCTTTGAGATCTTTCGCTTGACGGTCCAAATGCGGAACTCCCTG

TCCGAGCTCGAGGATAGAGATTATGATCGGCTGATATCTCCCGTGCTTAATGAAAAT

AACATCTTCTACGACTCCGCCAAGGCGGGTGATGCCCTGCCGAAGGATGCGGATGCT

AATGGCGCTTATTGCATTGCTCTTAAGGGGCTCTATGAGATAAAGCAGATCACGGAA

AACTGGAAAGAAGACGGTAAGTTTAGTAGAGACAAGCTGAAGATCTCAAATAAAGA

CTGGTTTGATTTCATACAGAACAAGCGGTACCTGAAACGTCCGGCAGCGACCAAAA

AAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAA

AAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0147] SEQ ID NO: 102

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAACAATGGCACTAA

CAATTTTCAGAATTTCATCGGCATTTCAAGTCTGCAAAAAACTCTGAGGAATGCTTT

GATCCCTACTGAAACCACTCAGCAATTTATAGTCAAGAACGGTATAATTAAAGAAG

ATGAACTCAGGGGTGAAAATAGACAAATACTCAAGGACATTATGGATGACTATTAT

AGAGGCTTCATCTCAGAGACTCTCTCATCAATAGATGATATCGATTGGACTAGCCTT

TTCGAGAAAATGGAGATTCAGTTGAAAAATGGTGATAACAAAGATACGTTGATAAA

GGAACAGACCGAGTACAGGAAAGCCATTCATAAGAAATTTGCTAATGACGATAGAT

TTAAGAATATGTTTAGTGCAAAACTGATTAGTGACATTCTGCCGGAGTTCGTTATCC

ATAATAATAACTACTCTGCATCCGAAAAGGAGGAAAAGACGCAAGTTATTAAACTG

TTCAGCCGCTTCGCCACAAGCTTCAAGGACTACTTCAAAAATAGAGCCAACTGCTTT

TCTGCCGACGATATATCATCATCTTCATGCCATCGGATCGTTAACGATAACGCCGAG ATATTCTTCAGCAACGCCCTTGTATATCGAAGAATAGTCAAAAGTCTGAGTAATGAT

GATATTAATAAAATTAGCGGTGATATGAAAGACTCCCTGAAGGAAATGTCACTGGA

GGAAATTTATAGTTACGAAAAGTACGGCGAATTCATTACTCAAGAAGGCATATCCTT

CTATAACGACATTTGCGGAAAGGTCAACTCATTCATGAACCTTTATTGCCAGAAGAA

TAAGGAGAATAAAAATCTTTACAAATTGCAAAAACTTCACAAACAAATTCTTTGCAT

CGCGGATACGTCCTACGAAGTTCCTTACAAATTTGAATCCGATGAGGAAGTGTATCA

GAGTGTCAATGGATTTTTGGATAATATCTCTTCAAAACATATTGTGGAGAGATTGCG

CAAAATAGGTGATAACTACAATGGCTACAACCTGGACAAGATTTATATTGTTAGCAA

GTTCTATGAAAGTGTCAGTCAAAAGACCTACAGAGATTGGGAGACAATCAACACGG

CGCTCGAAATACACTACAATAACATCCTCCCCGGCAATGGGAAGAGTAAAGCCGAT

AAGGTTAAAAAAGCTGTTAAGAACGACCTCCAGAAATCCATCACGGAAATAAACGA

GCTGGTTTCCAACTATAAGCTGTGTAGCGATGATAATATTAAGGCTGAGACATATAT

ACATGAGATCAGCCACATTCTCAACAATTTCGAGGCACAGGAACTCAAATACAATC

CCGAGATTCACTTGGTGGAAAGTGAGTTGAAGGCGTCAGAGCTTAAGAATGTACTT

GACGTAATAATGAATGCTTTTCATTGGTGCTCCGTGTTCATGACTGAGGAACTCGTG

GATAAGGATAATAACTTTTATGCGGAGTTGGAAGAGATATACGATGAAATATACCC

GGTTATCTCACTGTATAATCTGGTCAGAAATTACGTGACCCAAAAGCCTTATAGTAC

AAAAAAAATAAAGTTGAACTTCGGTATTCCGACATTGGCAGATGGTTGGTCCAAAA

GCAAAGAATACTCTAATAACGCCATTATATTGATGCGAGACAATTTGTATTACCTTG

GGATCTTTAACGCGAAAAACAAACCGGATAAGAAGATCATCGAAGGTAATACATCT

GAGAATAAGGGGGATTACAAGAAGATGATTTATAATCTGTTGCCGGGGCCAAACAA

GATGATTCCGAAGGTCTTTCTGTCATCTAAGACAGGAGTAGAGACCTACAAACCTTC

TGCGTACATTTTGGAAGGCTACAAACAGAACAAGCATATAAAATCTAGCAAGGACT

TTGATATCACGTTTTGTCATGATCTGATAGATTATTTCAAAAACTGCATCGCTATAC A

TCCTGAGTGGAAGAATTTCGGCTTTGACTTTTCTGACACCAGCACATACGAAGACAT

CTCAGGTTTCTACCGGGAAGTCGAGCTCCAGGGGTACAAGATTGACTGGACATATAT

AAGTGAAAAAGACATCGACCTCCTCCAAGAGAAGGGCCAACTTTACCTGTTCCAGA

TCTATAACAAAGACTTTTCTAAAAAGTCCACGGGTAACGACAACTTGCACACTATGT

ATCTGAAAAACTTGTTCTCTGAAGAGAACCTCAAGGACATCGTCCTGAAGCTTAACG

GGGAGGCGGAGATCTTCTTTAGAAAGTCCTCTATCAAAAATCCCATTATCCATAAAA

AGGGCTCTATACTCGTTAATAGGACATATGAAGCGGAGGAAAAAGATCAATTTGGG

AACATCCAGATCGTCCGGAAAAATATACCTGAGAATATCTATCAAGAGCTGTACAA

GTATTTTAATGATAAGTCAGACAAAGAGCTCAGTGATGAGGCGGCAAAGCTCAAGA

ACGTGGTGGGGCATCATGAAGCTGCGACGAACATTGTCAAAGATTATAGATACACT

TACGATAAATACTTCCTCCACATGCCGATAACGATTAACTTCAAAGCCAATAAGACG GGGTTTATAAATGATCGGATCCTTCAGTACATTGCGAAAGAGAAAGACCTCCATGTG

ATCGGAATTGACCGAGGAGAAAGGAATCTGATTTACGTGTCCGTGATTGATACTTGC

GGGAATATAGTCGAGCAAAAGAGTTTCAACATAGTCAACGGGTATGACTATCAGAT

AAAGCTCAAACAGCAGGAAGGTGCGAGGCAAATTGCGCGCAAAGAGTGGAAGGAG

ATAGGCAAGATTAAAGAAATCAAGGAAGGTTATCTCAGCTTGGTGATCCATGAAAT

ATCTAAGATGGTTATAAAGTACAATGCCATAATAGCCATGGAGGATCTTTCCTACGG

GTTTAAGAAGGGCCGATTTAAAGTGGAGCGACAAGTTTACCAGAAGTTCGAAACCA

TGTTGATTAACAAACTTAACTATTTGGTGTTCAAGGATATAAGTATAACCGAAAACG

GCGGTTTGCTTAAGGGTTATCAGCTCACGTATATTCCTGATAAACTTAAAAACGTTG

GACACCAGTGTGGATGTATCTTCTACGTGCCAGCCGCTTACACTAGTAAGATAGATC

CTACCACGGGGTTTGTGAATATTTTTAAGTTTAAAGACTTGACAGTCGACGCCAAAA

GGGAATTTATAAAAAAGTTTGATTCTATCCGCTACGATAGTGAAAAAAATCTCTTTT

GCTTTACTTTCGACTATAACAACTTCATTACGCAGAACACTGTCATGAGTAAGTCCA

GCTGGAGCGTCTACACATATGGCGTCCGAATTAAACGACGATTTGTAAACGGGCGG

TTTTCAAACGAATCTGACACGATAGACATTACCAAGGATATGGAGAAGACACTTGA

GATGACCGACATAAACTGGCGGGACGGTCACGATCTTCGGCAGGACATAATTGATT

ACGAAATCGTCCAGCATATATTCGAAATATTTCGACTTACAGTGCAAATGCGGAACA

GTCTCTCTGAACTGGAAGATCGCGATTATGACCGGTTGATTTCTCCGGTCCTCAATG

AAAATAACATATTTTATGATAGTGCTAAGGCAGGTGATGCGTTGCCAAAGGATGCA

GACGCTAATGGTGCCTATTGTATCGCGCTCAAGGGATTGTACGAGATAAAGCAAATT

ACGGAGAACTGGAAGGAGGATGGTAAGTTTAGCCGAGACAAGTTGAAGATTAGCAA

TAAAGACTGGTTTGATTTTATCCAAAACAAGAGGTACCTGAAACGTCCGGCAGCGA

CCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAG

CCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGG

GCTAA

[0148] SEQ ID NO: 103

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAACGGAACTA

ATAACTTTCAAAATTTCATAGGTATTTCAAGCTTGCAGAAGACCCTGAGGAATGCCC

TGATTCCAACCGAGACAACGCAGCAGTTCATAGTCAAAAATGGCATTATTAAGGAA

GATGAGCTGCGGGGGGAAAACCGACAGATACTCAAGGATATTATGGACGACTATTA

CCGGGGATTTATCTCAGAAACGCTGAGCAGTATTGATGACATCGATTGGACCAGTCT

TTTCGAGAAAATGGAAATTCAACTTAAGAATGGTGACAATAAAGACACTCTCATAA

AGGAGCAAACTGAATACCGAAAAGCCATACACAAAAAGTTTGCCAACGATGACCGC

TTTAAAAA CATGTTTTCA GCTAA GCTCATTAGCGACATTCTCCCCGAGTTTGTGATTC

ATAACAATAACTATAGCGCATCCGAGAAGGAGGAAAAAACCCAAGTTATCAAATTG TTCAGTAGATTCGCTACGAGCTTTAAAGATTACTTTAAAAACCGGGCTAACTGCTTC

AGTGCAGACGATATCAGCTCCTCATCCTGTCATCGCATCGTCAATGATAATGCTGAG

ATCTTCTTTTCTAATGCACTGGTTTACCGCAGGATAGTTAAGTCTCTTAGTAACGAC G

ACATCAACAAGATATCAGGAGATATGAAGGATTCCCTTAAAGAAATGAGTCTCGAG

GAGATATATTCTTATGAAAAATACGGCGAATTTATTACCCAAGAGGGCATTAGTTTC

TATAATGACATATGCGGAAAAGTTAATAGTTTTATGAATCTCTATTGTCAGAAGAAT

AAGGAGAATAAGAACCTCTACAAATTGCAGAAGTTGCACAAGCAAATTCTGTGTAT

CGCGGACACCTCTTACGAGGTCCCATATAAGTTCGAGAGTGATGAAGAAGTATACC

AGAGCGTTAATGGGTTCCTGGACAACATCTCAAGTAAACACATAGTCGAAAGGCTC

CGAAAGATCGGTGATAACTATAACGGATATAATTTGGATAAAATTTATATAGTTAGC

AAATTTTACGAGAGCGTCAGTCAGAAGACCTACCGGGACTGGGAGACCATAAACAC

AGCGCTGGAAATACATTATAACAACATACTGCCTGGGAACGGTAAGTCAAAGGCAG

ACAAGGTTAAAAAGGCTGTGAAGAATGACCTGCAAAAATCAATTACAGAAATAAAT

GAGTTGGTAAGTAATTACAAACTTTGCAGCGATGATAATATAAAGGCAGAGACGTA

CATACATGAAATATCTCATATCCTCAACAATTTCGAAGCCCAAGAACTGAAGTACAA

CCCGGAAATTCATCTTGTAGAGTCTGAGTTGAAGGCCTCCGAATTGAAAAACGTTCT

TGACGTAATTATGAATGCCTTCCACTGGTGCTCAGTATTCATGACGGAAGAGCTCGT

GGATAAAGACAACAATTTTTACGCTGAACTGGAAGAAATATATGACGAGATTTACC

CCGTAATTTCACTCTACAACTTGGTACGAAATTACGTTACCCAAAAGCCATACTCAA

CAAAAAAAATTAAACTGAACTTCGGGATACCCACCCTCGCAGATGGATGGTCAAAG

TCCAAAGAGTACAGTAACAATGCAATTATCCTGATGCGAGACAACCTTTATTACCTC

GGGATTTTCAACGCTAAAAATAAACCTGATAAAAAAATAATTGAGGGTAATACCTC

TGAAAACAAGGGGGATTATAAAAAGATGATATACAATCTGCTGCCTGGCCCGAACA

AAATGATTCCTAAAGTCTTCTTGTCTTCCAAGACTGGAGTCGAAACCTACAAGCCAA

GTGCTTATATACTCGAAGGGTACAAACAAAATAAGCACATAAAATCCAGCAAGGAT

TTTGATATTACATTCTGCCACGATTTGATTGATTATTTTAAGAACTGTATAGCCATC C

ACCCAGAATGGAAGAATTTTGGTTTTGATTTTAGCGATACCTCAACATATGAGGATA

TCTCTGGCTTTTACCGCGAGGTAGAACTGCAAGGTTATAAGATCGATTGGACTTATA

TTTCTGAAAAGGACATAGATCTCCTGCAAGAGAAAGGGCAACTTTATTTGTTTCAAA

TATACAACAAAGATTTTAGTAAGAAGAGTACTGGCAATGATAACCTTCACACTATGT

ATCTGAAGAACCTTTTTTCTGAGGAGAACTTGAAGGACATAGTCCTTAAACTCAATG

GGGAAGCTGAAATATTCTTTCGCAAAAGCTCCATTAAAAACCCGATCATTCATAAAA

AGGGTTCCATCTTGGTAAACCGCACATACGAGGCGGAAGAAAAAGATCAGTTCGGA

AATATCCAGATCGTAAGGAAGAATATCCCCGAAAATATATACCAAGAGCTTTACAA

ATATTTTAACGATAAGTCAGACAAGGAACTGTCAGACGAAGCAGCCAAGTTGAAGA ATGTCGTAGGGCACCACGAAGCAGCTACAAACATAGTTAAAGATTATCGGTACACC

TACGATAAATATTTCCTGCATATGCCAATAACCATAAACTTCAAAGCCAACAAAACA

GGGTTCATCAATGACCGAATACTTCAGTATATAGCCAAGGAAAAAGACCTGCATGTT

ATAGGAATAGATAGAGGTGAGCGCAACTTGATATATGTCAGCGTGATAGACACCTG

CGGAAATATCGTCGAGCAAAAAAGTTTCAACATTGTTAATGGCTACGATTACCAAAT

TAAATTGAAGCAGCAAGAGGGGGCTCGGCAAATCGCGCGAAAGGAATGGAAAGAA

ATCGGGAAGATTAAAGAAATTAAAGAGGGCTACCTGTCTCTTGTAATTCACGAAAT

ATCTAAGATGGTCATCAAGTATAATGCCATTATTGCGATGGAAGATCTGTCCTACGG

ATTTAAGAAAGGCAGGTTTAAAGTCGAAAGGCAGGTGTACCAGAAATTCGAGACCA

TGCTGATTAATAAGCTCAACTATCTCGTATTTAAGGATATTTCTATAACTGAAAATG

GAGGGCTTCTCAAAGGATATCAACTCACATACATACCTGATAAGCTGAAGAACGTA

GGCCACCAGTGTGGATGCATATTCTATGTACCAGCTGCATACACAAGCAAGATCGAT

CCAACTACTGGGTTTGTCAATATCTTCAAATTTAAGGACTTGACGGTCGATGCCAAA

CGGGAGTTCATCAAAAAGTTTGATAGTATTCGATATGATAGTGAGAAGAACTTGTTT

TGCTTCACATTTGACTACAACAATTTCATAACGCAAAATACGGTTATGTCTAAATCC

TCATGGAGCGTCTACACTTACGGAGTGAGGATAAAGCGGCGCTTCGTAAATGGCAG

GTTTAGCAATGAATCCGACACGATTGACATAACCAAGGATATGGAGAAAACCCTCG

AGATGACCGATATAAATTGGCGGGATGGACACGATCTGCGACAAGACATAATCGAT

TATGAAATCGTGCAGCACATATTTGAGATATTCAGGCTTACGGTCCAAATGAGAAAT

TCCCTTTCCGAACTTGAAGACCGCGATTACGACCGACTGATAAGCCCCGTTCTGAAC

GAAAATAACATCTTCTACGACAGCGCTAAAGCGGGAGACGCGCTGCCGAAAGATGC

GGACGCAAATGGAGCCTATTGTATCGCCTTGAAAGGGTTGTACGAGATCAAACAGA

TAACCGAGAATTGGAAGGAGGATGGGAAGTTTAGTCGAGACAAACTTAAAATAAGC

AACAAGGACTGGTTCGACTTTATTCAAAACAAACGATATCTCAAACGTCCGGCAGC

GACCAAAAAAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGC

AGCCCGAAAAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCC

GGGCTAA

[0149] SEQ ID NO: 104

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGTACTAA

CAATTTTCAAAACTTTATCGGCATCTCTTCACTTCAGAAAACTCTTCGGAACGCCCT T

ATACCGACGGAGACAACGCAGCAGTTTATAGTTAAAAACGGGATCATTAAAGAAGA

TGAACTCAGAGGGGAAAACAGGCAAATATTGAAGGACATTATGGACGATTACTACC

GGGGGTTTATTTCAGAGACCCTTTCATCTATTGATGACATAGATTGGACCTCCCTTT T

CGAGAAAATGGAGATACAATTGAAAAACGGCGACAATAAAGATACACTTATCAAGG

AACAAACTGAGTATCGCAAGGCGATTCACAAGAAGTTTGCGAATGACGATCGCTTT AAGAATATGTTTTCTGCGAAGCTCATAAGTGACATTCTGCCTGAATTTGTCATTCATA

ACAACAATTATTCTGCTAGCGAAAAAGAGGAAAAAACTCAAGTCATTAAGCTTTTTA

GCAGGTTCGCTACTAGTTTTAAAGACTATTTTAAGAACCGGGCGAATTGCTTTAGCG

CTGACGACATATCATCCTCATCCTGTCATCGCATAGTCAATGATAATGCAGAAATAT

TCTTTTCTAATGCGCTCGTGTATCGGAGAATAGTGAAAAGCCTCTCTAACGATGACA

TTAACAAAATAAGCGGCGATATGAAGGATAGTCTGAAGGAAATGTCCCTCGAAGAA

ATATACTCATACGAGAAGTACGGAGAATTTATCACCCAGGAAGGAATTAGTTTTTAC

AACGACATCTGTGGTAAGGTTAACTCTTTTATGAATCTGTATTGTCAAAAGAATAAA

GAAAATAAAAATCTTTATAAGCTCCAAAAGCTTCACAAACAAATCTTGTGCATTGCG

GATACGTCATACGAAGTACCTTACAAATTTGAAAGCGACGAAGAGGTGTATCAGTC

AGTGAATGGGTTCCTTGACAATATTTCTAGCAAACATATTGTGGAGCGACTTCGAAA

GATCGGTGATAATTACAATGGCTATAATTTGGATAAAATTTACATAGTTAGTAAGTT

TTATGAATCCGTCTCACAAAAGACGTACCGAGATTGGGAGACCATCAACACTGCTCT

GGAGATTCATTACAATAATATATTGCCTGGGAATGGGAAGTCAAAGGCCGACAAGG

TTAAAAAAGCCGTAAAAAACGATCTTCAAAAGTCCATTACCGAGATAAATGAACTT

GTATCCAACTATAAGTTGTGCTCTGACGATAATATTAAAGCAGAAACGTATATCCAC

GAAATAAGTCACATCCTGAACAACTTCGAAGCTCAAGAGCTCAAGTATAATCCTGA

AATTCATCTCGTCGAAAGCGAGCTGAAAGCATCCGAGTTGAAGAATGTGCTTGATGT

GATCATGAACGCATTCCATTGGTGCAGTGTGTTCATGACCGAAGAACTTGTAGACAA

AGACAACAACTTCTACGCTGAATTGGAAGAGATTTACGATGAAATTTACCCCGTGAT

ATCCCTCTATAATCTGGTAAGAAATTACGTCACGCAAAAACCATACAGTACCAAGA

AAATAAAGCTCAACTTTGGTATTCCGACGTTGGCAGATGGGTGGAGTAAGAGCAAG

GAGTATTCTAACAATGCAATCATCCTCATGCGCGACAATTTGTATTATCTGGGGATC

TTCAACGCGAAAAATAAGCCCGACAAAAAGATAATAGAAGGCAATACGTCCGAGA

ACAAAGGGGACTATAAGAAAATGATTTATAACCTTCTTCCAGGACCCAACAAGATG

ATCCCAAAGGTTTTCTTGAGTTCAAAAACCGGCGTAGAAACTTATAAACCGTCCGCC

TACATTCTGGAAGGGTACAAGCAAAACAAGCACATTAAGTCATCTAAGGATTTCGA

CATTACTTTTTGTCATGATTTGATAGACTACTTCAAAAATTGTATAGCGATACATCC G

GAATGGAAAAATTTTGGGTTCGATTTTTCCGACACAAGTACTTATGAAGACATCTCA

GGGTTTTATAGGGAAGTTGAACTGCAAGGTTACAAAATAGACTGGACTTATATTAGT

GAGAAGGACATTGATTTGCTCCAGGAAAAGGGTCAATTGTATCTGTTCCAGATATAT

AACAAGGATTTCTCTAAAAAATCTACAGGTAACGACAATCTCCACACGATGTACCTC

AAGAATCTCTTCAGCGAAGAGAATTTGAAGGATATCGTACTTAAGCTCAATGGAGA

AGCGGAAATATTCTTCAGAAAGTCCAGCATTAAGAATCCTATAATTCACAAGAAAG

GGTCAATTCTCGTAAACCGGACTTATGAGGCCGAAGAAAAAGATCAGTTTGGTAAC ATTCAGATTGTACGGAAAAACATTCCCGAGAACATCTATCAAGAACTGTATAAATAC TTTAATGATAAATCCGACAAGGAACTTTCTGACGAGGCTGCAAAATTGAAGAACGT AGTGGGACACCATGAGGCCGCAACCAATATAGTAAAGGATTACAGATACACTTATG ATAAGTATTTCCTCCATATGCCGATCACGATTAATTTCAAGGCGAATAAAACCGGCT TCATTAACGATCGCATTTTGCAATATATTGCGAAGGAAAAGGATTTGCACGTGATAG GTATAGACCGGGGTGAACGAAACTTGATTTACGTCTCTGTGATCGACACATGCGGAA ATATAGTTGAACAGAAGTCCTTTAATATTGTGAATGGTTACGACTACCAGATAAAAT TGAAGCAACAGGAGGGCGCAAGACAGATAGCTCGCAAAGAGTGGAAGGAAATCGG CAAGATCAAAGAAATAAAGGAGGGTTATCTTTCCCTGGTAATTCATGAAATTAGCA AGATGGTTATTAAGTATAATGCTATAATAGCTATGGAGGACCTTTCCTATGGGTTCA AGAAAGGTCGCTTCAAAGTGGAGCGACAAGTGTATCAAAAGTTCGAGACTATGTTG ATAAATAAATTGAATTATTTGGTTTTTAAAGACATTTCAATAACTGAGAACGGGGGT CTCTTGAAGGGGTACCAATTGACTTATATTCCGGACAAGTTGAAGAATGTCGGACAC CAGTGTGGTTGCATTTTCTACGTGCCTGCCGCTTACACCTCAAAAATCGATCCGACC ACTGGTTTTGTAAATATATTTAAATTCAAAGATCTCACCGTTGATGCCAAACGGGAG TTTATCAAAAAATTCGATTCCATTCGCTACGACTCTGAGAAAAACCTTTTTTGTTTCA CGTTCGATTATAACAACTTTATAACCCAAAATACTGTAATGTCCAAGTCAAGTTGGT CTGTCTATACTTACGGAGTAAGGATCAAGCGCCGCTTCGTTAATGGGAGATTCTCAA ACGAGTCTGATACCATAGACATAACTAAAGACATGGAAAAAACCCTGGAAATGACG GACATCAATTGGCGAGACGGGCATGATCTTCGACAGGACATAATAGATTACGAAAT TGTTCAACACATTTTCGAGATATTTCGACTTACGGTTCAGATGAGGAATTCCCTTTCC GAATTGGAAGACCGGGATTATGATCGACTTATATCTCCCGTGCTCAATGAAAACAAT _{ATTTTTTATGATTCAGCGAAAGCTGGGGACGCGCTGCCAAAAGATGCCGATGCCA AT} GGAGCATACTGTATCGCCCTGAAGGGTTTGTATGAGATTAAGCAAATTACTGAAAAC TGGAAGGAAGATGGCAAGTTTTCTAGAGATAAGCTTAAGATTAGCAATAAGGACTG GTTTGACTTCATTCAAAATAAAAGGTATCTTAAACGTCCGGCAGCGACCAAAAAAG CCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAAAAA GAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA [0150] SEQ ID NO: 105

CCAGCGGCTAAAAAAAAGAAACTGGATGGCAGCGTGGATATGAATAATGGAACAA

ATAATTTTCAAAATTTTATTGGTATCAGTTCATTGCAAAAGACTTTGAGAAATGCTT T

GATCCCGACTGAGACCACACAGCAGTTCATCGTCAAAAATGGCATAATCAAGGAAG

ACGAACTTAGGGGTGAGAATAGACAAATATTGAAGGACATCATGGATGACTATTAT

AGGGGGTTCATTTCCGAAACGCTCAGTAGTATTGATGACATTGACTGGACTAGTCTT

TTCGAGAAAATGGAAATTCAGCTTAAGAACGGGGACAATAAAGACACGCTGATCAA GGAGCAAACGGAATATAGGAAGGCGATCCATAAAAAATTCGCGAATGATGATCGGT

TTAAAAACATGTTTAGTGCCAAGTTGATCAGCGACATACTGCCCGAATTCGTGATCC

ACAACAATAATTACAGCGCCTCCGAAAAGGAGGAAAAAACTCAGGTCATTAAATTG

TTTAGCCGATTCGCAACGAGTTTCAAAGATTATTTTAAGAACCGGGCCAACTGTTTT

TCAGCGGATGATATTAGCTCCAGCAGCTGCCATCGCATAGTAAATGATAACGCTGAA

ATCTTTTTTAGCAACGCACTTGTCTACCGGAGGATTGTAAAATCACTGTCAAATGAT

GACATTAACAAAATATCTGGAGATATGAAGGACTCACTCAAAGAAATGAGCCTGGA

AGAAATATATTCATACGAAAAATACGGGGAGTTTATTACCCAGGAAGGTATCAGTTT

TTATAATGATATATGTGGAAAAGTTAATTCATTTATGAATCTTTACTGTCAAAAAAA

TAAGGAGAACAAGAATTTGTACAAGCTCCAAAAACTTCATAAACAGATTCTGTGCA

TCGCAGACACAAGTTATGAGGTACCGTACAAATTTGAGAGCGACGAAGAAGTTTAT

CAGAGTGTGAATGGTTTCCTGGACAATATCTCTTCTAAACACATTGTTGAGAGGCTT

AGGAAGATCGGTGATAATTATAACGGCTATAATCTGGACAAAATTTATATTGTATCA

AAGTTTTATGAATCAGTCTCTCAAAAGACGTATCGGGATTGGGAAACAATTAACACG

GCTCTGGAGATCCACTACAATAACATTCTGCCCGGCAACGGGAAGAGCAAAGCTGA

TAAGGTCAAGAAGGCAGTCAAGAACGACCTTCAGAAGAGCATAACAGAAATTAACG

AATTGGTCAGTAACTACAAACTGTGTAGTGATGACAACATAAAAGCCGAAACATAC

ATCCATGAAATAAGCCATATCCTGAATAACTTCGAAGCCCAAGAACTTAAATACAAT

CCCGAGATTCATCTTGTCGAATCAGAACTCAAGGCGTCCGAGCTCAAAAATGTCCTT

GACGTGATAATGAATGCCTTCCACTGGTGCAGCGTATTCATGACGGAGGAGTTGGTA

GATAAAGACAACAACTTTTATGCCGAATTGGAAGAGATTTATGATGAGATTTACCCC

GTTATTTCTCTGTACAACTTGGTTCGAAACTACGTAACACAAAAACCATACTCAACC

AAAAAGATCAAACTCAATTTTGGCATACCTACATTGGCTGATGGTTGGTCCAAGTCA

AAGGAATATAGCAATAATGCAATAATTCTCATGCGAGATAACTTGTATTATTTGGGG

ATCTTTAACGCTAAGAACAAACCAGATAAAAAGATAATCGAGGGGAACACAAGTGA

GAACAAGGGTGATTACAAAAAAATGATTTACAATCTGCTTCCTGGGCCTAACAAAA

TGATTCCGAAGGTGTTTCTTAGCTCTAAAACTGGAGTGGAGACGTATAAGCCTTCCG

CGTACATTCTCGAAGGCTACAAGCAAAATAAGCATATCAAGTCCAGTAAGGACTTC

GACATCACTTTTTGCCACGATCTCATCGATTACTTTAAGAACTGTATCGCAATACAC C

CCGAGTGGAAAAACTTTGGTTTTGATTTTTCAGACACTAGTACCTACGAGGACATTT

CCGGCTTCTATCGAGAAGTCGAACTCCAGGGCTACAAAATCGATTGGACGTACATTT

CTGAGAAGGACATCGACTTGCTCCAAGAGAAAGGTCAACTTTACCTCTTCCAAATTT

ACAATAAAGACTTTTCAAAGAAGAGCACCGGTAATGACAACTTGCATACCATGTAT

CTGAAGAACCTGTTTTCTGAGGAGAACCTCAAGGATATTGTATTGAAGTTGAATGGC

GAAGCAGAAATATTTTTCCGAAAGTCATCTATCAAGAACCCCATTATACACAAAAA AGGCTCTATCCTGGTGAACCGGACTTACGAGGCAGAGGAGAAGGATCAATTCGGAA

ACATACAGATAGTCCGCAAAAACATCCCTGAGAATATCTATCAGGAACTCTATAAGT

ACTTCAATGATAAATCAGACAAGGAGCTTAGCGACGAAGCAGCTAAACTTAAAAAC

GTGGTTGGCCATCACGAGGCCGCTACCAACATAGTCAAAGACTACCGCTATACTTAT

GACAAGTACTTTTTGCACATGCCCATAACAATTAATTTCAAAGCTAACAAAACAGGG

TTTATAAATGACAGAATCCTCCAATACATCGCCAAAGAGAAGGACCTCCATGTAATC

GGGATTGATAGAGGCGAACGGAACTTGATTTACGTTAGTGTCATTGATACCTGTGGT

AACATTGTCGAACAAAAGTCATTCAACATAGTCAATGGATATGATTATCAGATAAA

ACTCAAGCAACAAGAAGGCGCGAGGCAGATTGCCAGGAAGGAATGGAAAGAAATC

GGGAAGATCAAGGAGATCAAGGAGGGTTACCTGTCCTTGGTGATACACGAGATTTC

AAAAATGGTTATAAAATACAATGCCATTATCGCGATGGAGGATTTGTCTTATGGATT

TAAGAAGGGGAGGTTCAAAGTCGAACGACAAGTCTATCAGAAGTTTGAAACAATGC

TCATTAACAAGCTCAATTACCTTGTTTTCAAGGATATAAGCATCACTGAAAACGGCG

GACTCCTTAAGGGATATCAGCTGACTTATATCCCCGACAAGCTCAAGAACGTAGGGC

ACCAATGCGGATGCATCTTTTACGTGCCTGCAGCATATACTTCAAAAATTGATCCGA

CTACTGGCTTTGTTAACATTTTCAAGTTCAAGGATCTGACGGTAGACGCTAAGAGAG

AATTCATAAAAAAGTTTGACAGCATCAGGTACGATAGTGAAAAGAACCTTTTTTGTT

TTACCTTTGACTACAATAATTTTATTACGCAAAATACAGTTATGAGCAAATCAAGTT

GGAGCGTTTACACATATGGCGTTCGGATCAAGCGCAGATTCGTCAATGGTCGCTTCT

CAAATGAGAGCGATACAATCGATATAACGAAGGATATGGAGAAGACGCTTGAGATG

ACAGATATCAACTGGCGGGACGGACATGACCTTAGACAAGACATAATCGATTACGA

AATAGTACAGCATATCTTTGAGATTTTTAGGCTTACAGTTCAGATGCGGAACTCTCT T

TCCGAACTGGAGGACCGGGATTATGATCGGTTGATCTCCCCAGTACTGAACGAAAAT

AATATCTTTTACGATAGCGCGAAGGCTGGTGATGCACTCCCAAAAGACGCTGATGCG

AACGGAGCTTATTGCATAGCCCTTAAAGGGCTTTACGAGATTAAACAAATAACAGA

AAATTGGAAGGAAGATGGCAAATTTTCCCGCGACAAGTTGAAGATTAGTAACAAAG

ACTGGTTCGACTTCATTCAGAATAAACGCTACCTCAAACGTCCGGCAGCGACCAAAA

AAGCCGGCCAGGCGAAGAAAAAAAAAGCGTCAGGTAGCGGCGCAGGCAGCCCGAA

AAAGAAACGTAAAGTCGAGGATCCGAAAAAGAAACGTAAGGTTATTCCGGGCTAA

[0151] SEQ ID NO: 113

ATGGGCCATCATCATCATCATCATAGCAGCGGCGTGGATCTGGGCACCGAAAACCT

GTATTTTCAGTCCATGAGCCGCCGCCGCAAAGCGAACCCGACCAAACTGAGCGAAA

ACGCGAAAAAACTGGCGAAAGAAGTGGAAAACGCAAGCGGCAGCGGCGCGGGCAG

CAAACGACCGGCGGCGACCAAAAAAGCGGGCCAAGCGAAGAAAAAGAAAGCAAGC

GGCAGCGGCGCGGGCAGCCCGGCGGCAAAAAAAAAAAAACTGGACGGCAGCGTGG ATGCAAGCGGCAGCGGCGCGGGCAGCCCCAAAAAAAAACGCAAAGTTGAAGATGC

AAGCGGCAGCGGCGCGGGCAGCCCGAAAAAAAAACGTAAAGTGGCAAGCGGCAGC

GGCGCGGGCAGCATGAACAACGGCACCAACAACTTTCAGAACTTTATTGGCATTAG

CAGCCTGCAGAAAACCCTGCGCAACGCGCTGATTCCGACCGAAACCACGCAGCAGT

TTATTGTGAAAAACGGCATTATTAAAGAAGATGAACTGCGCGGCGAAAACCGTCAG

ATTCTGAAGGACATTATGGATGATTATTATCGCGGCTTTATTAGCGAAACCCTGAGC

AGCATTGATGATATAGACTGGACGAGCCTGTTTGAAAAAATGGAAATTCAGCTGAA

AAACGGCGATAACAAAGATACCCTGATTAAAGAACAGACCGAATATCGCAAAGCGA

TTCATAAGAAGTTTGCGAACGATGATCGCTTTAAAAACATGTTTAGCGCGAAACTGA

TTAGCGATATTCTGCCGGAATTTGTGATTCATAACAACAACTATAGCGCGAGCGAAA

AGGAAGAAAAAACCCAAGTGATTAAACTGTTTAGCCGCTTTGCGACGAGCTTTAAA

GATTATTTTAAAAATCGCGCGAACTGCTTTAGCGCGGATGATATTAGCAGCAGCAGC

TGCCATCGCATTGTGAACGATAACGCGGAGATCTTTTTTAGCAATGCGCTGGTGTAT

CGCCGCATTGTGAAAAGCCTGAGCAACGATGATATTAACAAAATTAGCGGCGATAT

GAAAGATAGCCTGAAAGAAATGAGCCTGGAAGAAATATATAGCTATGAAAAATATG

GGGAATTTATTACACAAGAGGGCATTAGCTTTTATAACGATATTTGCGGCAAAGTGA

ACAGCTTTATGAACCTGTATTGTCAGAAAAACAAAGAAAACAAAAACCTGTATAAA

CTGCAGAAACTGCATAAACAGATTCTGTGCATTGCGGATACGAGCTATGAAGTGCC

GTATAAATTTGAAAGCGATGAAGAAGTGTATCAGAGCGTGAACGGCTTTCTGGATA

ACATTAGCAGCAAACATATTGTGGAACGCCTGCGCAAAATTGGCGATAACTATAAC

GGCTATAACCTGGATAAAATTTATATTGTGAGCAAATTTTATGAAAGCGTGAGTCAG

AAAACCTATCGCGATTGGGAAACCATTAACACCGCGCTGGAAATTCATTATAACAA

CATTCTGCCGGGC AACGGC AAAAGT AA AGCGGATAAAGT GAAAAAAGCGGT GA AA

AACGATCTGCAGAAAAGCATTACGGAAATTAACGAACTGGTGAGCAACTATAAACT

GTGCAGCGATGATAACATTAAAGCGGAAACCTATATTCACGAGATCAGTCATATTCT

GAACAACTTTGAAGCGCAAGAACTGAAATATAACCCGGAAATTCATCTGGTGGAAT

CAGAACTGAAGGCGAGCGAACTTAAGAATGTGCTAGATGTGATTATGAACGCGTTT

CATTGGTGCAGCGTGTTTATGACCGAAGAACTGGTGGATAAAGATAACAACTTTTAT

GCGGAACTGGAAGAAATCTACGACGAAATTTATCCGGTGATTAGCCTGTATAACCTG

GTGCGCAACTATGTGACGCAGAAACCGTATAGCACCAAAAAAATTAAACTGAACTT

TGGCATTCCGACCCTGGCGGATGGCTGGAGCAAGAGCAAAGAGTATAGCAACAACG

CTATTATCCTAATGCGCGATAACCTGTATTATCTGGGCATTTTTAACGCGAAAAACA

AACCGGATAAAAAAATTATTGAAGGCAACACGAGCGAAAACAAAGGCGATTATAA

AAAAATGATTTATAACCTGCTGCCGGGCCCGAACAAAATGATTCCGAAAGTGTTTCT

GAGCAGCAAAACCGGCGTGGAAACCTATAAACCGAGCGCGTATATTCTGGAAGGCT ATAAACAGAACAAACATATTAAAAGCAGCAAAGATTTTGATATTACCTTTTGCCATG

ATCTGATTGACTACTTTAAGAACTGTATAGCGATTCATCCGGAATGGAAAAACTTTG

GCTTTGATTTTAGCGATACGAGCACCTATGAAGACATTAGCGGCTTTTATCGCGAAG

TGGAACTGCAAGGCTATAAAATTGATTGGACCTATATTAGCGAAAAAGATATTGATC

TGCTGCAAGAAAAAGGTCAGCTGTATCTGTTTCAGATTTATAACAAAGATTTTAGCA

AAAAAAGCACCGGCAACGATAACCTGCATACCATGTATCTGAAAAATCTGTTTTCTG

AAGAAAACCTAAAAGATATTGTCCTGAAACTGAACGGCGAAGCCGAAATTTTTTTTC

GCAAGAGCAGCATTAAAAACCCGATTATTCACAAAAAAGGTAGCATTCTGGTGAAC

CGCACATACGAAGCTGAGGAAAAGGATCAGTTTGGCAACATTCAGATTGTGCGCAA

AAACATTCCGGAAAACATCTACCAAGAACTGTACAAATATTTTAACGATAAAAGCG

ATAAAGAACTGAGCGACGAGGCTGCGAAGCTGAAGAATGTCGTGGGCCATCATGAA

GCGGCGACTAACATTGTCAAAGATTATCGCTATACCTATGATAAATATTTTCTGCAT

ATGCCGATTACCATTAACTTTAAAGCGAACAAAACCGGCTTTATTAACGATCGCATT

CTGCAGTATATTGCGAAGGAAAAGGATCTGCACGTGATTGGCATTGATCGCGGCGA

ACGCAACCTGATTTATGTGAGCGTGATTGATACCTGCGGCAACATTGTGGAACAGAA

AAGCTTTAACATCGTGAACGGCTATGATTATCAGATTAAACTGAAACAGCAAGAAG

GCGCGCGTCAGATTGCGCGCAAAGAATGGAAAGAAATTGGCAAAATTAAAGAAATT

AAAGAAGGCTATCTGAGCCTGGTGATTCATGAAATCAGCAAGATGGTGATTAAATA

TAATGCCATTATTGCGATGGAAGATCTGAGCTATGGCTTTAAAAAAGGCCGCTTTAA

AGTGGAACGCCAAGTGTATCAGAAATTTGAAACCATGCTGATTAACAAACTGAACT

ATCTGGTGTTTAAAGATATTAGTATTACTGAAAATGGCGGCCTGCTGAAAGGCTATC

AGCTGACCTATATTCCGGACAAGCTGAAGAATGTGGGCCATCAGTGCGGCTGCATTT

TTTATGTGCCGGCGGCGTATACGAGCAAAATTGATCCGACCACCGGCTTTGTGAACA

TTTTTAAATTTAAAGATCTGACCGTGGATGCGAAACGGGAATTCATAAAAAAATTTG

ATAGCATTCGCTATGATAGCGAAAAGAATCTGTTTTGCTTCACCTTTGATTATAACA

ACTTTATAACGCAGAACACCGTGATGAGCAAAAGCAGCTGGAGCGTGTATACCTAT

GGCGTGCGCATTAAACGCCGCTTTGTGAACGGCCGCTTTAGCAACGAAAGCGATAC

CATTGATATTACCAAAGATATGGAAAAAACCCTGGAAATGACCGATATTAACTGGC

GCGATGGCCATGATCTGCGCCAAGATATTATTGATTATGAAATTGTGCAGCATATTT

TTGAAATTTTTCGCCTGACCGTGCAGATGCGCAACAGCCTGAGCGAACTGGAAGATC

GCGATTATGATCGCCTGATTAGCCCGGTGCTGAACGAAAACAACATTTTTTATGATA

GCGCGAAAGCGGGCGATGCGCTGCCGAAAGATGCGGATGCGAACGGCGCGTATTGC

ATTGCGCTGAAAGGCCTGTATGAAATTAAACAGATTACGGAAAACTGGAAAGAAGA

TGGCAAATTTAGCCGCGACAAGCTGAAAATTAGCAACAAAGATTGGTTTGATTTTAT

TCAGAACAAACGCTATCTGTA [0152] In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO:2. In certain embodiments, a nucleic acid- guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity , preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to amino acid sequence of SEQ ID NO:2. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO: 3. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical, to amino acid sequence of SEQ ID NO: 3. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO: 4. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to amino acid sequences of SEQ ID NO: 4. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to any one of SEQ ID NOs: 109-112. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to amino acid sequence of any one of SEQ ID NOs: 109-112. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO: 109. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 109. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO: 110. In certain embodiments, a nucleic acid- guided nuclease disclosed herein includes a polypeptide having an amino acid sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 110. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO: 111. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 111. In certain embodiments, a nucleic acid-guided nuclease, e.g., Type V, preferably Type VA CRISPR nuclease polypeptide disclosed herein includes a polypeptide having an amino acid sequence of at least 50% identity to SEQ ID NO: 112. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 112.

Nuclear Localization Signals (NLSs)

[0153] In certain embodiments, a composition, e.g., nuclease, disclosed herein includes one or more nuclear localization sequences (NLSs), such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more NLSs. In some embodiments, a composition, e.g., engineered nuclease comprises 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more NLSs at or near the amino-terminus, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more NLSs at or near the carboxy -terminus, or a combination of these (e.g. one or more NLS at the amino- terminus and one or more NLS at the carboxy terminus). When more than one NLS is present, each may be selected independently of the others, such that a single NLS may be present in more than one copy and/or in combination with one or more other NLSs present in one or more copies. In certain embodiments the engineered nuclease comprises 4 NLSs.

[0154] Non-limiting examples of NLSs include an NLS sequence derived from: the NLS of the SV40 virus large T-antigen, having the amino acid sequence PKKKRKV (SEQ ID NO:5); the NLS from nucleoplasmin (e.g. the nucleoplasmin bipartite NLS with the sequence KRPAATKKAGQAKKKK (SEQ ID NO:6); the c-myc NLS having the amino acid sequence PAAKRVKLD SEQ ID NO:7) or RQRRNELKRSP (SEQ ID NO:8); the hRNPAl M9 NLS having the sequence NQ S SNF GPMKGGNF GGRS S GP Y GGGGQ YFAKPRNQGGY (SEQ ID NO:9); the sequence RMRIZFKNKGKDTAELRRRRVEVSVELRKAKKDEQILKRRNV (SEQ ID NO:10) of the IBB domain from importin-alpha; the sequences VSRKRPRP (SEQ ID NO:ll) and PPKKARED (SEQ ID NO:12) of the myoma T protein; the sequence PQPKKKPL (SEQ ID NO:13) of human p53; the sequence SALIKKKKKMAP (SEQ ID NO:14) of mouse c-abl IV; the sequences DRLRR (SEQ ID NO:15) and PKQKKRK (SEQ ID NO:16) of the influenza virus NS 1; the sequence RKLKKKIKKL (SEQ ID NO:17) of the Hepatitis virus delta antigen; the sequence REKKKFLKRR (SEQ ID NO:18) of the mouse Mxl protein; the sequence KRKGDEVDGVDEVAKKKSKK (SEQ ID NO:19) of the human poly(ADP-ribose) polymerase; the sequence RKCLQAGMNLEARKTKK (SEQ ID NO:20) of the steroid hormone receptors (human) glucocorticoid; and EGL-13, MSRRRKANPTKLSENAKKLAKEVEN, SEQ ID NO: 107 .

[0155] In certain embodiments, a nuclease provided herein comprises at least one myc- related NLS comprising the sequence PAAKKKKLD (SEQ ID NO:21); in certain embodiments the myc-related NLS is at the N-terminus of the nuclease. In certain embodiments, a nuclease provided herein comprises at least one nucleoplasmin NLS comprising the sequence KRPAATKKAGQAKKKK (SEQ ID NO:6); in certain embodiments the nucleoplasmin NLS is at the C-terminus of the nuclease. In certain embodiments a nuclease provided herein comprises at least one, or at least two, SV40 NLS sequences comprising the sequence PKKKRKV (SEQ ID NO:5); in certain embodiments the SV40 NLSs are at the C-terminus of the nuclease. In certain embodiments, a nuclease provided herein comprises 1 NLS at the N-terminus and 3 NLSs at the C-terminus, for example 1 myc-related NLS at the N-terminus and one nucleoplasmin NLS and two SV40 NLSs at the C-terminus. In certain embodiments, a nuclease provided herein comprises 1 myc-related NLS at the N-terminus with the sequence PAAKKKKLD (SEQ ID NO:21 and one nucleoplasmin NLS comprising the sequence KRPAATKKAGQAKKKK (SEQ ID NO:6) and two SV40 NLSs comprising the sequence PKKKRKV (SEQ ID NO:5) at the C- terminus.

[0156] In general, the one or more NLSs are of sufficient strength to drive accumulation of the nucleic acid-guided nuclease in a detectable amount in the nucleus of a eukaryotic cell. In general, strength of nuclear localization activity may derive from the number of NLSs, the particular NLS(s) used, or a combination of these factors. Detection of accumulation in the nucleus may be performed by any suitable technique. For example, a detectable marker may be fused to the nucleic acid-guided nuclease, such that location within a cell may be visualized, such as in combination with a means for detecting the location of the nucleus (e.g. a stain specific for the nucleus such as DAPI). Cell nuclei may also be isolated from cells, the contents of which may then be analyzed by any suitable process for detecting protein, such as immunohistochemistry, Western blot, or enzyme activity assay. Accumulation in the nucleus may also be determined indirectly, such as by an assay for the effect of the nucleic acid-guided nuclease complex formation (e.g. assay for DNA cleavage or mutation at the target sequence, or assay for altered gene expression activity affected by targetable nuclease complex formation and/or nucleic acid-guided nuclease activity), as compared to a control not exposed to the nucleic acid-guided nuclease or targetable nuclease complex, or exposed to a nucleic acid-guided nuclease lacking the one or more NLSs.

[0157] In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4 and at least one myc-related NLS comprising the sequence PAAKKKKLD (SEQ ID NO:21); in certain embodiments the myc-related NLS is at the N-terminus of the nuclease. In certain embodiments, a nucleic acid- guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4 and at least one nucleoplasmin NLS comprising the sequence KRPAATKKAGQAKKKK (SEQ ID NO:6); in certain embodiments the nucleoplasmin NLS is at the C-terminus of the nuclease. . In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4 and at least one, or at least two, SV40 NLS sequences comprising the sequence PKKKRKV; in certain embodiments the SV40 NLSs are at the C-terminus of the nuclease. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4 and one NLS at the N-terminus and three NLSs at the C-terminus, for example 1 myc-related NLS at the N-terminus and one nucleoplasmin NLS and two SV40 NLSs at the C-terminus. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4, and one myc-related NLS at the N-terminus with the sequence PAAKKKKLD (SEQ ID NO:21) and one nucleoplasmin NLS comprising the sequence KRPAATKKAGQAKKKK (SEQ ID NO:6) and two SV40 NLSs comprising the sequence PKKKRKV (SEQ ID NO:5) at the C- terminus. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 1, and one, two, or three NLS at the N-terminus and one, two, or three NLS at the C-terminus. In certain embodiments, a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 1, and one myc-related NLS at the N-terminus with the sequence PAAKKKKLD (SEQ ID NO:21) and one nucleoplasmin NLS comprising the sequence KRPAATKKAGQAKKKK (SEQ ID NO:6) and two SV40 NLSs comprising the sequence PKKKRKV (SEQ ID NO:5) at the C-terminus.

Purification Tags

[0158] In certain embodiments, a nucleic acid-guided nuclease provided herein can comprise a tag, e.g., a purification tag, e.g. at the N-terminus. Exemplary tags include a poly-his tag, such as a Gly-6x His tag or Gly-8x His tag, short epitope tags such as FLAG, hemagglutinin (HA), c- myc, T7, and Glu-Glu; maltose binding protein (mbp); N-terminal glutathione .S'-transfcrasc (GST); calmodulin binding peptide (CBP). In certain embodiments, a nucleic acid-guided nuclease provided herein can comprise a poly-his tag, such as a Gly-6x His tag, e.g., at the N- terminus. These Gly-6xHis tags are applied for several reasons including: 1) a 6xHis tag can be used in protein purification to allow binding to the chromatographic columns for purification, and 2) the N-terminal glycine allows further, site-specific, chemical modifications that permit advanced protein engineering. Further, the Gly-6xHis is designed for easy removal, if desired, by digestion with Tobacco Etch Virus (TEV) protease. For these constructs, the Gly-6xHis tag was positioned on the N-terminus. Gly-6xHis tags are further described in Martos-Maldonado et al., Nat Commun. (2018) 17;9(1):3307, the disclosure of which is incorporated herein. Thus, in certain embodiments provided herein is a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4 and a poly-His tag at the N- terminus, such as a Gly-6x His tag. In certain embodiments provided herein is a nucleic acid- guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4, a poly-His tag at the N-terminus, such as a Gly-6x His tag, and/or a TEV cleavage site at the N-terminus. In certain embodiments provided herein is a nucleic acid-guided nuclease having a poly-His tag at the N-terminus, such as a Gly-6x His tag and a TEV cleavage site at the N-terminus, such as a polypeptide having at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 2. In certain embodiments provided herein is a nucleic acid-guided nuclease disclosed herein includes a polypeptide having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 1, a poly-His tag at the N-terminus, such as a Gly-6x His tag, and/or a TEV cleavage site at the N-terminus. Additionally or alternatively, the nuclease may comprise one or more NLS as described herein.

Cleavage Sites

[0159] In addition to, or alternatively to, including one or more NLSs, purification tags, and/or other additional amino acid sequences described herein, an engineered nuclease polypeptide disclosed herein can include one or more cleavage sites, which can be at or near the N-terminus or the C-terminus. Any suitable cleavage site can be used; if a plurality of cleavage sits is used, they may be the same or different. In certain embodiments a cleavage site comprises a Tobacco Etch Virus protease cleavage sequence, herein referred to as a “TEV sequence” (SEQ ID NO: 108). The TEV sequence can be at or near the amino terminus. Generally, the cleavage sequence, e.g., TEV sequence, is located so that cleavage at the cleavage sequence leaves other additional amino acid sequences, in particular any NLS added to the original nuclease polypeptide, intact. A TEV clevage site can have the amino acid sequence ENLYFQS (SEQ ID. NO: 108.

[0160] In certain embodiments, provided herein is a nucleic acid sequence encoding a polypeptide having at least 50% nucleic acid identity to a polypeptide represented by SEQ ID NO: 2. In certain embodiments, provided herein is a nucleic acid sequence encoding a polypeptide having at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% to a polypeptide represented by SEQ ID NO: 2. In certain embodiments, provided herein is a nucleic acid sequence encoding a polypeptide having at least at least 50% nucleic acid identity to a polypeptide represented by SEQ ID NO: 3. In certain embodiments, provided herein is a nucleic acid sequence encoding a polypeptide having at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% to a polypeptide represented by SEQ ID NO:

3. In certain embodiments, provided herein is a nucleic acid sequence encoding a polypeptide having at least at least 50% nucleic acid identity to a polypeptide represented by SEQ ID NO: 4. In certain embodiments, provided herein is a nucleic acid sequence encoding a polypeptide having at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, greater than 95%, or 100% to a polypeptide represented by SEQ ID NO: 4. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 23-105. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%,

99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 23-42 In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 43- 65. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 43-53. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 54-58. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 59-63. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NO: 43. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 64-84. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%,

99%, or 100% polynucleotide identity to any one of SEQ ID NO: 64. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 64-74. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 75-79. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 80-84. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 85-105. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NO: 85. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 85-95. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 96-100. In certain embodiments, provided herein is a nucleic acid of at least about 50%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%,

99%, or 100% polynucleotide identity to any one of SEQ ID NOS: 101-105.

[0161] A nucleic acid sequence encoding a nucleic acid-guided nuclease can be operably linked to a promoter. Such nucleic acid sequences can be linear or circular. The nucleic acid sequences can be encompassed on a larger linear or circular nucleic acid sequences that comprises additional elements such as an origin of replication, selectable or screenable marker, terminator, other components of a targetable nuclease system, such as a guide nucleic acid, and/or an editing or recorder cassette as disclosed herein. In some aspects, nucleic acid sequences can include sequences that code for at least one glycine, at least one poly -histidine tag, such as a 6X histidine tag, and/or at least one, two, three, four, or five nuclear localization signal tags, some or all of which can be on the amino side of the polypeptide, the carboxy side of the polypeptide, or a combination thereof. Larger nucleic acid sequences can be recombinant expression vectors, as are described in more detail later.

Guide nucleic acids

[0162] In certain embodiments, compositions and methods disclosed herein include a guide nucleic acid (gNA), e.g., a gRNA.

[0163] In general, a guide polynucleotide, also referred to as a guide nucleic acid (gNA) can complex with a compatible nucleic acid-guided nuclease, such as those disclosed herein, and can hybridize with a target nucleic acid sequence, thereby directing the nuclease to the target nucleic acid sequence. A subject nucleic acid-guided nuclease capable of complexing with a guide polynucleotide can be referred to as a nucleic acid-guided nuclease that is compatible with the guide polynucleotide. In addition, a guide polynucleotide capable of complexing with a nucleic acid-guided nuclease can be referred to as a guide polynucleotide or a guide nucleic acid that is compatible with the nucleic acid-guided nuclease. In some embodiments, a polynucleotide (gRNA) disclosed herein can be split into fragments, e.g., two separate polynucleotides, in some cases encompassing a synthetic tracrRNA and crRNA. Such gNAs, e.g., gRNAs, can be referred to as dual or split gNA, e.g., gRNA.

[0164] A guide polynucleotide can be DNA. A guide polynucleotide can be RNA. A guide polynucleotide can include both DNA and RNA. A guide polynucleotide can include modified or non-naturally occurring nucleotides. In cases where the guide polynucleotide comprises RNA, the RNA guide polynucleotide can be encoded by a DNA sequence on a polynucleotide molecule such as a plasmid, linear construct or editing cassette as disclosed herein.

[0165] A guide polynucleotide can comprise a guide sequence, also referred to herein as a spacer sequence. A guide (spacer) sequence is a polynucleotide sequence having sufficient complementarity with a target polynucleotide sequence, also referred to herein as a target nucleic acid sequence, to hybridize with the target sequence and direct sequence-specific binding of a complexed nucleic acid-guided nuclease to the target sequence. The degree of complementarity between a guide sequence and its corresponding target sequence, when optimally aligned using a suitable alignment algorithm, is about or more than about 50%, 60%, 75%, 80%, 85%, 90%,

95%, 97.5%, 99%, or more. Optimal alignment may be determined with the use of any suitable algorithm for aligning sequences. In some embodiments, a guide sequence can be about or more than about 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 75, or more nucleotides in length. In other embodiments, a guide sequence can be less than about 75, 50, 45, 40, 35, 30, 25, 20 nucleotides in length. Preferably the guide sequence is 10-30 nucleotides long. The guide sequence can be 15-20 nucleotides in length. The guide sequence can be 15 nucleotides in length. The guide sequence can be 16 nucleotides in length. The guide sequence can be 17 nucleotides in length. The guide sequence can be 18 nucleotides in length. The guide sequence can be 19 nucleotides in length. The guide sequence can be 20 nucleotides in length.

[0166] A guide polynucleotide can include a scaffold sequence. In general, a “scaffold sequence” can include any sequence that has sufficient sequence to promote formation of a targetable nuclease complex, wherein the targetable nuclease complex includes, but is not limited to, a nucleic acid-guided nuclease and a guide polynucleotide that can include a scaffold sequence and a guide sequence. Sufficient sequence within the scaffold sequence to promote formation of a targetable nuclease complex may include a degree of complementarity along the length of two sequence regions within the scaffold sequence, such as one or two sequence regions involved in forming a secondary structure. In some cases, the one or two sequence regions are included or encoded on the same polynucleotide. In some cases, the one or two sequence regions are included or encoded on separate polynucleotides. Optimal alignment may be determined by any suitable alignment algorithm, and may further account for secondary structures, such as self-complementarity within either the one or two sequence regions. In some embodiments, the degree of complementarity between the one or two sequence regions along the length of the shorter of the two when optimally aligned is about or more than about 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 97.5%, 99%, or higher. In some embodiments, at least one of the two sequence regions can be about or more than about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 40, 50, or more nucleotides in length.

[0167] A scaffold sequence of a subject guide polynucleotide can comprise a secondary structure. A secondary structure can comprise a pseudoknot region. In some cases, binding kinetics of a guide polynucleotide to a nucleic acid-guided nuclease is determined in part by secondary structures within the scaffold sequence. In some cases, binding kinetics of a guide polynucleotide to a nucleic acid-guided nuclease is determined in part by nucleic acid sequence with the scaffold sequence. In some aspects, the invention provides a nuclease that binds to a guide polynucleotide can include a conserved scaffold sequence. For example, the nucleic acid- guided nucleases for use in the present disclosure can bind to a conserved pseudoknot region. [0168] In certain embodiments, the engineered polynucleotide (gRNA) can be split into fragments encompassing a synthetic tracrRNA and crRNA. [0169] As used herein, “guide nucleic acid” or “guide polynucleotide” can refer to one or more polynucleotides and can include 1) a guide (spacer) sequence capable of hybridizing to a target sequence and 2) a scaffold sequence capable of interacting with or complexing with a nucleic acid-guided nuclease as described herein. A guide nucleic acid can be provided as one or more nucleic acids. In specific embodiments, the guide sequence and the scaffold sequence are provided as a single polynucleotide. In other aspects, guide nucleic acid may include at least one amplicon targeting fragments.

[0170] A guide nucleic acid can be compatible with a nucleic acid-guided nuclease when the two elements can form a functional targetable nuclease complex capable of cleaving a target sequence. In certain methods, a compatible scaffold sequence for a compatible guide nucleic acid can be found by scanning sequences adjacent to a native nucleic acid-guided nuclease loci. For example, native nucleic acid-guided nucleases can be encoded on a genome within proximity to a corresponding compatible guide nucleic acid or scaffold sequence.

[0171] Nucleic acid-guided nucleases can be compatible with guide nucleic acids that are not found within the nucleases endogenous host. Such orthogonal guide nucleic acids can be determined by empirical testing. Orthogonal guide nucleic acids can come from different bacterial species or be synthetic or otherwise engineered to be non-naturally occurring.

[0172] Orthogonal guide nucleic acids that are compatible with a common nucleic acid- guided nuclease can comprise one or more common features. Common features can include sequence outside a pseudoknot region. Common features can include a pseudoknot region. Common features can include a primary sequence or secondary structure.

[0173] A guide nucleic acid can be engineered to target a desired target sequence by altering the guide (spacer) sequence such that the guide sequence is complementary to the target sequence, thereby allowing hybridization between the guide sequence and the target sequence. A guide nucleic acid with an engineered guide sequence can be referred to as an engineered guide nucleic acid. Engineered guide nucleic acids are often non-naturally occurring and are not found in nature.

[0174] Engineered guide nucleic acids can be formed using a Synthetic Tracr RNA (STAR) system. STAR, when combined with a Casl2a protein, can form at least one ribonucleoprotein (RNP) complex that targets a specific genomic locus. STAR takes advantage of the natural properties of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) where the CRISPR system functions much like an immune system against invading viruses and plasmid DNA. Short DNA sequences (spacers) from invading viruses are incorporated at CRISPR loci within the bacterial genome and serve as “memory” of previous infections. Reinfection triggers complementary mature CRISPR RNA (crRNA) to find a matching viral sequence. Together, the crRNA and trans-activating crRNA (tracrRNA) guide CRISPR-associated (Cas) nuclease to cleave double-strand breaks in “foreign” DNA sequences. The prokaryotic CRISPR “immune system” has been engineered to function as an RNA-guided, mammalian genome editing tool that is simple, easy and quick to implement. STAR (which includes synthetic crRNA and tracrRNA) when combined with Cas 12a protein can form ribonucleoprotein (RNP) complexes that target a specific genomic locus. Engineered guide nucleic acids formed with the RNA (STAR) system can result in a split gRNA. Split gRNA, i.e., dual guide RNAs are described more fully in WO 2021067788A1.

[0175] In certain embodiments, provided herein are ribonucleoprotein (RNP) complexes that include at least one nuclease disclosed herein. In certain embodiments, a RNP complex can include at least one nuclease having an amino acid sequence of at least 50% identity to SEQ ID NO:2. In certain embodiments, a RNP complex can include at least one nuclease having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO:2. In certain embodiments, a RNP complex can include at least one nuclease having an amino acid sequence of at least 50% identity to SEQ ID NO:3. In certain embodiments, a RNP complex can include at least one nuclease having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO:3. In certain embodiments, a RNP complex can include at least one nuclease having an amino acid sequence of at least 50% identity to SEQ ID NO:4. In certain embodiments, a RNP complex can include at least one nuclease having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO:4. In certain embodiments, a RNP complex including a nuclease disclosed herein can further include at least one STAR gRNA (dual guide RNA). In certain embodiments, a RNP complex including a nuclease disclosed herein can further include at least one non-STAR gRNA (e.g., single guide RNA). In certain embodiments, a RNP complex including a nuclease disclosed herein can further include at least one polynucleotide. In certain embodiments, a polynucleotide included in a RNP complex disclosed herein can be greater than about 50 nucleotides in length. In certain embodiments, a polynucleotide included in a RNP complex disclosed herein can be about 50, to about 150, to about 500, to about 1000 nucleotides, or greater than 1000 nucleotides in length. In certain embodiments, more than one nuclease can be added to an RNP complex to affect the overall editing efficiency. In certain embodiments, more than one gRNA can be added to the RNP complex to allow for multiplexed editing of more than one site in a single transfection for improved efficiency. In other embodiments, more than one DNA template can be added to the RNP to allow for multiplexed editing at one or more sites based on a specific desired repair outcome. [0176] In certain embodiments, a composition comprising a Type V, e.g., Type VA, CRISPR nuclease polypeptide, such as described herein, further comprises a guide nucleic acid (gNA), e.g., gRNA, comprising a spacer sequence that targets a target nucleotide sequence (also referred to herein as a target nucleic acid sequence) within a polynucleotide (also referred to herein as a target polynucleotide, as will be clear from context), or a polynuclotide coding for the gNA, e.g., gRNA, wherein the gNA, e.g., gRNA is compatible with the Type V, e.g., Type VA, CRISPR nuclease. In general, a polynucleotide within which a target target nucleotide sequence (target nucleic acid sequence) is located, as that term is used herein, includes a polynucleotide that includes the target target nucleotide sequence (target nucleic acid sequence). Such a polynucleotide can be any suitable polynucleotide, such as a genome of a cell or part of a genome of a cell. In certain embodiments, the target nucleotide sequence (target nucleic acid sequence) is within 50 nucleotides of a protospacer adjacent motif (PAM) sequence specific for the Type V CRISPR nuclease, such as a PAM comprising a sequence of YTTN, wherein Y is T or C and N is A, T, G, or C, or a sequence of YTTV or TTTV, wherein V is A, G, or C. In certain embodiments the PAM comprises a sequence of YTTV or TTTV, wherein V is A, G, or C. In certain embodiments, the gNA is a gRNA, such as a dual (split) gRNA. The gNA, e.g. gRNA, can comprise one or more chemical modifications, such as 2’-0-alkyl, a 2'-0-methyl, a phosphorothioate, a phosphonoacetate, a thiophosphonoacetate, a 2'-0-methyl-3'- phosphorothioate, a 2'-0-methy 1-3 '-phosphonoacetate, a 2 '-O-methy 1-3 '-thiophosphonoacetate, a 2'-deoxy-3 '-phosphonoacetate, a 2'-deoxy-3 '-thiophosphonoacetate, a suitable alternative, or a combination thereof. In certain embodiments, a ratio of guanine: uracil in the gRNA is at least 51:49, 52:48, 53:47, 54:46, 55:45, 56:44, 57:43, 58:42, 59:42, or 60:40, preferably at least 53:47, more preferably at least 54:46, even more preferably at least 55:45. See Example 12 and Figure 10. In certain embodiments, a molar ratio of gNA, e.g., gRNA to Type V CRISPR nuclease is at least 1.1: 1, 1.2:1, 1.3: 1, 1.4: 1, 1.5: 1, 1.6: 1, 1.7:1, 1.8: 1, 2: 1, 2.2: 1, 2.5:1, or 3: 1 and/or not more than 1.2: 1, 1.3: 1, 1.4: 1, 1.5:1, 1.6: 1, 1.7: 1, 1.8: 1, 2:1, 2.2: 1, 2.5: 1, 3: 1, or 4:1, preferably 1.1: 1 to 2.5: 1, more preferably 1.2:1 to 2: 1„ even more preferably 1.2: 1 to 1.7: 1. See, e.g., Example 13. In certain embodiments a molar amount of gNA, e.g., gRNA, is at least 10, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 170, 190 or 200 pmol and/or not more than 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 170, 190 , 200, 250, or 300 pmol, preferably 25-200 pmol, more preferably 50-100 pmol, even more preferably 65 to 85 pmol. See Exmple 13.

[0177] In certain embodiments, a composition comprising a Type V, e.g., Type VA, CRISPR nuclease polypeptide, such as described herein, further includes a donor template, also referred to as an editing template herein. A donor template can comprise homology arms, that is, nucleotide sequences that are complementary with polynucleotide sequenes on either side of a cleavage site at which the donor template will be inserted. The donor template can be present in any suitable amount, e.g., in certain embodiments, at least 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.7, 2, 2.5, 3, 4, or 5 pg pL ¹ and/or not more than 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8,

0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.7, 2, 2.5, 3, 4, 5, 7, or 10 pg pL ¹ , preferably 0.3 to 2 pg pL ¹ , more preferably 0.5 to 1.5 pg pL ¹ , even more preferably 0.8 to 1.2 pg pL ¹ .

[0178] In certain embodiments, a composition comprising a Type V, e.g., Type VA, CRISPR nuclease polypeptide, such as described herein, further includes an anionic polymer. Any suitable anionic polymer may be used. Exemplary anionic polymers include 1,2,3-heptanetriol, 2-Amino-2-(hydroxymethyl)-l, 3-propanediol (Tris), 3 -(l-pyridino)-l -propane sulfonate (NDSB 201), 3-[(3-cholamidopropyl)dimethylammonio]-l-propanesulfonate (CHAPS), 6-aminocaproic acid, adenosine diphosphate (ADP), adenosine triphosphate (ATP), alpha-cyclodextrin, amidosulfobetaine-14 (ASB-14), ammonium acetate, ammonium nitrate, ammonium sulfate, arginine, arginine ethylester, barium chloride, barium iodide, benzamidine HC1, beta- cyclodextrin, beta-mercaptoethanol (BME), biotin, calcium chloride, cesium chloride, cesium sulfate, cetyltrimethylammonium bromide (CTAB), choline chloride, citric acid, cobalt chloride, copper (II) chloride, cyclohexanol, D-sorbitol, dimethylethylammoniumpropane sulfonate (NDSB 195), dithiothreitol (DTT), erythritol, ethanol, ethylene glycol, ethylene glycol-bis(Pbeta- aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), ethylenediaminetetraacetic acid (EDTA), formamide, gadolinium bromide, gamma butyrolactone, glucose, glutamic acid, glutamine, glycerol, glycine, glycine betaine, glycine-glycine-glycine, guanidine HC1, guanosine triphosphate (GTP), holmium chloride, imidazole, iron (III) chloride, Jeffamine M-600, lanthanum acetate, lauryl sulfobetaine, lauryldimethylamine N-oxide (LDAO), lithium sulfate, magnesium chloride, magnesium sulfate, manganese chloride, mannitol, N-(2- hydroxyethyl)piperazine-N'-(3-propanesulfonic acid) (EPPS), N-dodecyl beta-D-maltoside (DDM), N-ethylurea, n-hexanol, N-lauryl sarcoside, N-lauryl sarcosine, N-methylformamide, N- methylurea, n-octyl-b-D-glucoside (OG: Octyl glucoside), n-penthanol, nickel chloride, non detergent sulfo betaine (NDSB), Nonidet P40 (NP40), octyl beta-D-glucopyranoside, poly-L- glutamic acid, polyethylene glycol (for example, PEG 300, PEG 3350, PEG 4000), polyethyleneglycol lauryl ether (Brij 35), polyoxyethylene (2) oleyl ether (Brij 93), polyoxyethylene cetyl ether (Brij 56), polyvinylpyrrolidone 40 (PVP40), potassium chloride, potassium citrate, potassium nitrate, proline, putrescine, spermidine, spermine, riboflavin, samarium bromide, sarcosine, sodium acetate, sodium chloride, sodium dodecyl sulfate (SDS), sodium fluoride, sodium iodide, sodium lauroyl sarcosinate (Sarkosyl), sodium malonate, sodium molybdate, sodium selenite, sodium sulfate, sodium thiocyanate, sucrose, taurine, trehalose, tricine, triethylamine, trimethylamine N-oxide (TMAO), tris(2-carboxyethyl)phosphine (TCEP), Triton X-100, Tween 20, Tween 60, Tween 80, urea, vitamin B12, xylitol, yttrium chloride, yttrium nitrate, zinc chloride, Zwittergent 3-08, Zwittergent 3-14, or a combination thereof. In certain embodiments, an anionic polymer comprises polyglutamic acid. In certain embodiments, the anionic polymer, e.g., PGA, is present at a concentration of at least 20, 50, 60, 70, 80, 90,

100, 110, 120, 130, 140, 150, 170, 200, 250, 300, 400, or 500 pg pL ¹ and/or not more than 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 170, 200, 250, 300, 400, 500, 700, or 1000 pg pL ¹ , preferably 20 to 200 pg pL ¹ , more preferably 50 to 150 pg pL ¹ , even more preferably 80 to 120 pg pL ¹ (PGA).

[0179] In certain embodiments, provided herein is a cell containing one or more of the compositions described herein, e.g. a composition comprising a Type V, e.g., Type VA, CRISPR nuclease polypeptide comprising one or more NLSs and, in certain embodiments a purification tag and/or cleavage site. Any suitable cell may be used. In certain embodiments the cell is a human cell, such as an immune cell, e.g., T cell, or a stem cell, e.g., induced pluripotent stem cell (iPSC).

[0180] In certain embodiments, provided herein are methods of inserting one or more of the compositions described herein, e.g., a composition comprising a Type V, e.g., Type VA,

CRISPR nuclease polypeptide comprising one or more NLSs and, in certain embodiments a purification tag and/or cleavage site, into a cell. Any suitable method for insertion may be used. In certain embodiments, electroporation is used. Electroporation conditions can be optimized, see, e.g., Examples.

[0181] In certain embodiments provided are methods of modifying a target polynucleotide comprising contacting the target polynucleotide with a composition or compositions as described herein, e.g, a composition comprising a Type V, e.g., Type VA, CRISPR nuclease polypeptide comprising one or more NLSs and a suitable gNA, e.g., gRNA, and allowing the composition to modify the target polynucleotide, in some cases a genomic region, such as a genome or part of a genome within a cell, e.g. human cell such as an immune cell, e.g., T cell, or a stem cell, e.g., iPSC. In certain cases, the composition or compositions comprises a donor template, such as a donor template comprising a polynucleotide coding for a polypeptide to be expressed by the cell, in certain embodiments the polypeptide comprises a chimeric antigen receptor (CAR) or portion thereof; see, e.g., Examples. In certain embodiments the cell is a human cell, e.g., immune cell such as a T cell, or stem cell, such as an iPSC.

Nuclease Systems

[0182] In certain embodiments disclosed herein are targetable nuclease systems. In certain embodiments, targetable nuclease system can include a nucleic acid-guided nuclease and a compatible guide nucleic acid (also referred to interchangeably herein as “guide polynucleotide” and “gRNA”). A targetable nuclease system can include a nucleic acid-guided nuclease or a polynucleotide sequence encoding the nucleic acid-guided nuclease. A targetable nuclease system can include a guide nucleic acid or a polynucleotide sequence encoding the guide nucleic acid.

[0183] In general, a targetable nuclease system as disclosed herein can be characterized by elements that promote the formation of a targetable nuclease complex at the site of a target sequence, wherein the targetable nuclease complex includes a nucleic acid-guided nuclease and a guide nucleic acid.

[0184] A guide nucleic acid together with a nucleic acid- guided nuclease forms a targetable nuclease complex which is capable of binding to a target sequence within a target polynucleotide, as determined by the guide sequence of the guide nucleic acid.

[0185] In general, to generate a double stranded break, in most cases a targetable nuclease complex binds to a target sequence as determined by the guide nucleic acid, and the nuclease has to recognize a protospacer adjacent motif (PAM) sequence adjacent to the target sequence.

[0186] A targetable nuclease complex can include a nucleic acid-guided nuclease having an amino acid sequence of at least 50% identity to SEQ ID NO: 2 and a compatible guide nucleic acid. A targetable nuclease complex can include a nucleic acid-guided nuclease having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences SEQ ID NO: 2 and a compatible guide nucleic acid protospacer adjacent motif (PAM) sequence adjacent to the target sequence. A targetable nuclease complex can include a nucleic acid-guided nuclease having an amino acid sequence of at least 50% identity to SEQ ID NO: 3 and a compatible guide nucleic acid. A targetable nuclease complex can include a nucleic acid-guided nuclease having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 3 and a compatible guide nucleic acid. A targetable nuclease complex can include a nucleic acid-guided nuclease having an amino acid sequence of at least 50% identity to SEQ ID NO: 4 and a compatible guide nucleic acid. A targetable nuclease complex can include a nucleic acid-guided nuclease having an amino acid sequence of at least about 60%, 65%, 75%, 85%, 95%, 99% or about 100% identity to amino acid sequences of SEQ ID NO: 4 and a compatible guide nucleic acid. In certain embodiments, the guide nucleic acid can include a scaffold sequence compatible with the nucleic acid-guided nuclease selected. In any of these embodiments, the guide sequence can be engineered to be complementary to any desired target sequence. The guide sequence selected can be engineered to hybridize to any desired target sequence. In certain embodiments, the guide sequence is a dual guide RNA. [0187] A target sequence of a targetable nuclease complex can be any polynucleotide endogenous or exogenous to a prokaryotic or eukaryotic cell, or in vitro. For example, the target sequence can be a polynucleotide residing in the nucleus of the eukaryotic cell. A target sequence can be a sequence coding a gene product (e.g., a protein) or a non-coding sequence (e.g., a regulatory polynucleotide or a junk DNA). It is contemplated herein that the target sequence should be associated with a PAM; that is, a short sequence recognized by a targetable nuclease complex. The precise sequence and length requirements for a PAM differ depending on the nucleic acid-guided nuclease used, but PAMs can be a 2-5 base pair sequences adjacent the target sequence. Examples of PAM sequences are given in the examples section below, and the skilled person will be able to identify further PAM sequences for use with a given nucleic acid-guided nuclease. Further, engineering of the PAM Interacting (PI) domain may allow programming of PAM specificity, improve target site recognition fidelity, and increase the versatility of a nucleic acid-guided nuclease genome engineering platform. Nucleic acid-guided nucleases may be engineered to alter their PAM specificity, for example as described in Kleinstiver et al., Nature. 2015 Jul. 23; 523 (7561): 481-5, the disclosure of which is incorporated herein in its entirety. [0188] A PAM site is a nucleotide sequence in proximity to a target sequence. In most cases, a nucleic acid-guided nuclease can only cleave a target sequence if an appropriate PAM is present. PAMs are nucleic acid-guided nuclease-specific and can be different between two different nucleic acid-guided nucleases. A PAM can be 5' or 3' of a target sequence. A PAM can be upstream or downstream of a target sequence. A PAM can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more nucleotides in length. Often, a PAM is between 2-6 nucleotides in length.

[0189] In some embodiments disclosed herein, a PAM can be provided on a separate oligonucleotide. In such cases, providing PAM on a oligonucleotide allows cleavage of a target sequence that otherwise would not be able to be cleave because no adjacent PAM is present on the same polynucleotide as the target sequence.

[0190] Polynucleotide sequences encoding a component of a targetable nuclease system can include one or more vectors. In general, the term “vector” as used herein can refer to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. Vectors include, but are not limited to, nucleic acid molecules that are single-stranded, double-stranded, or partially double-stranded; nucleic acid molecules that comprise one or more free ends, no free ends (e.g. circular); nucleic acid molecules that comprise DNA, RNA, or both; and other varieties of polynucleotides known in the art. One type of vector is a “plasmid,” which refers to a circular double stranded DNA loop into which additional DNA segments can be inserted, such as by standard molecular cloning techniques. Another type of vector is a viral vector, wherein virally-derived DNA or RNA sequences are present in the vector for packaging into a virus (e.g. retroviruses, replication defective retroviruses, adenoviruses, replication defective adenoviruses, and adeno-associated viruses). Other vectors (e.g., non-episomal mammalian vectors) can be integrated into the genome of a host cell upon introduction into the host cell. Recombinant expression vectors can include a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, can mean that the recombinant expression vectors include one or more regulatory elements, which may be selected on the basis of the host cells to be used for expression, that is operatively-linked to the nucleic acid sequence to be expressed.

[0191] In some embodiments, a regulatory element can be operably linked to one or more elements of a targetable nuclease system so as to drive expression of the one or more components of the targetable nuclease system.

[0192] In some embodiments, a vector can include a regulatory element operably linked to a polynucleotide sequence encoding a nucleic acid-guided nuclease. The polynucleotide sequence encoding the nucleic acid-guided nuclease can be codon optimized for expression in targeted cells, such as prokaryotic or eukaryotic cells. Eukaryotic cells can be yeast, fungi, algae, plant, animal, or human cells. Eukaryotic cells can be those derived from an organism, such as a mammal, including but not limited to human, mouse, rat, rabbit, dog, or non-human mammal including non-human primate.

[0193] In general, codon optimization can refer to a process of modifying a nucleic acid sequence for enhanced expression in the host cells of interest by replacing at least one codon or more of the native sequence with codons that are more frequently or most frequently used in the genes of that host cell while maintaining the native amino acid sequence. Various species exhibit certain bias for codons of a certain amino acid. As contemplated herein, genes can be tailored for optimal gene expression in a given organism based on codon optimization. Codon usage tables are readily available, for example, at the “Codon Usage Database” available at www.kazusa.orjp and these tables can be adapted in a number of ways. See Nakamura, Y., et al. “Codon usage tabulated from the international DNA sequence databases: status for the year 2000” Nucl. Acids Res. 28:292 (2000).

[0194] A nucleic acid-guided nuclease and one or more guide nucleic acids can be delivered either as DNA or RNA. Delivery of a nucleic acid-guided nuclease and guide nucleic acid both as RNA (unmodified or containing base or backbone modifications) molecules can be used to reduce the amount of time that the nucleic acid-guided nuclease persists in the cell. This may reduce the level of off-target cleavage activity in the target cell. Since a nucleic acid-guided nuclease as mRNA takes time to be translated into protein, it can be advantageous to deliver the guide nucleic acid several hours following the delivery of the nucleic acid-guided nuclease mRNA, to maximize the level of guide nucleic acid available for interaction with the nucleic acid-guided nuclease protein. In other cases, the nucleic acid-guided nuclease mRNA and guide nucleic acid are delivered concomitantly. In other examples, the guide nucleic acid is delivered sequentially, such as 0.5, 1, 2, 3, 4, or more hours after the nucleic acid-guided nuclease mRNA. [0195] Guide nucleic acid in the form of RNA or encoded on a DNA expression cassette can be introduced into a host cell can include a nucleic acid-guided nuclease encoded on a vector or chromosome. The guide nucleic acid may be provided in the cassette one or more polynucleotides, which may be contiguous or non-contiguous in the cassette. In specific embodiments, the guide nucleic acid is provided in the cassette as a single contiguous polynucleotide.

[0196] A variety of delivery systems can be used to introduce a nucleic acid-guided nuclease (DNA or RNA) and guide nucleic acid (DNA or RNA) into a host cell. In accordance with these embodiments, systems of use can include, but are not limited to, yeast systems, lipofection systems, microinjection systems, biolistic systems, virosomes, liposomes, immunoliposomes, polycations, lipidmucleic acid conjugates, virions, artificial virions, viral vectors, electroporation, cell permeable peptides, nanoparticles, nanowires (Shalek et al., Nano Letters, 2012), exosomes. Molecular trojan horses liposomes (Pardridge et al., Cold Spring Harb Protoc; 2010; doi: 10.1101/pdb.prot5407) may be used to deliver an engineered nuclease and guide nuclease across the blood brain barrier.

[0197] In some embodiments, an editing template, also referred to herein as a donor template, is also provided. An editing template may be a component of a vector as described herein, contained in a separate vector, or provided as a separate polynucleotide, such as an oligonucleotide, linear polynucleotide, or synthetic polynucleotide. In some cases, an editing template is on the same polynucleotide as a guide nucleic acid. In some embodiments, an editing template is designed to serve as a template in homologous recombination, such as within or near a target sequence nicked or cleaved by a nucleic acid-guided nuclease as a part of a complex as disclosed herein. An editing template polynucleotide can be of any suitable length, such as about or more than about 10, 15, 20, 25, 50, 75, 100, 150, 200, 500, 1000, or more nucleotides in length. In some embodiments, the editing template polynucleotide is complementary to a portion of a polynucleotide can include the target sequence. When optimally aligned, an editing template polynucleotide might overlap with one or more nucleotides of a target sequences (e.g. about or more than about 1, 5, 10, 15, 20, 25, 30, 35, 40, or more nucleotides). In some embodiments, when a editing template sequence and a polynucleotide can include a target sequence are optimally aligned, the nearest nucleotide of the template polynucleotide is within about 1, 5, 10, 15, 20, 25, 50, 75, 100, 200, 300, 400, 500, 1000, 5000, 10000, or more nucleotides from the target sequence. [0198] In some embodiments, methods are provided for delivering one or more polynucleotides, such as or one or more vectors or linear polynucleotides as described herein, one or more transcripts thereof, and/or one or proteins transcribed therefrom, to a host cell. In some aspects, the invention further provides cells produced by such methods, and organisms can include or produced from such cells. In some embodiments, an engineered nuclease in combination with (and optionally complexed with) a guide nucleic acid is delivered to a cell. [0199] Conventional viral and non-viral based gene transfer methods can be used to introduce nucleic acids in cells, such as prokaryotic cells, eukaryotic cells, mammalian cells, or target tissues. Such methods can be used to administer nucleic acids encoding components of an engineered nucleic acid-guided nuclease system to cells in culture, or in a host organism. Non- viral vector delivery systems include DNA plasmids, RNA (e.g. a transcript of a vector described herein), naked nucleic acid, and nucleic acid complexed with a delivery vehicle, such as a liposome. Viral vector delivery systems include DNA and RNA viruses, which have either episomal or integrated genomes after delivery to the cell. Any gene therapy method known in the art is contemplated of use herein. Methods of non-viral delivery of nucleic acids include are contemplated herein. Adeno-associated virus (“AAV”) vectors may also be used to transduce cells with target nucleic acids, e.g., in the in vitro production of nucleic acids and peptides, and for in vivo and ex vivo gene therapy procedures.

[0200] In some embodiments, a host cell is transiently or non-transiently transfected with one or more vectors, linear polynucleotides, polypeptides, nucleic acid-protein complexes, or any combination thereof as described herein. In some embodiments, a cell in transfected in vitro, in culture, or ex vivo. In some embodiments, a cell is transfected as it naturally occurs in a subject. In some embodiments, a cell that is transfected is taken from a subject. In some embodiments, the cell is derived from cells taken from a subject, such as a cell line.

[0201] In some embodiments, a cell transfected with one or more vectors, linear polynucleotides, polypeptides, nucleic acid-protein complexes, or any combination thereof as described herein is used to establish a new cell line can include one or more transfection-derived sequences. In some embodiments, a cell transiently transfected with the components of an engineered nucleic acid-guided nuclease system as described herein (such as by transient transfection of one or more vectors, or transfection with RNA), and modified through the activity of an engineered nuclease complex, is used to establish a new cell line can include cells containing the modification but lacking any other exogenous sequence.

[0202] In some embodiments, one or more vectors described herein are used to produce a non-human transgenic cell, organism, animal, or plant. In some embodiments, the transgenic animal is a mammal, such as a mouse, rat, or rabbit. Methods for producing transgenic cells, organisms, plants, and animals are known in the art, and generally begin with a method of cell transformation or transfection, such as described herein.

[0203] In certain embodiments, an engineered nuclease complex, “target sequence” can refer to a sequence to which a guide sequence is designed to have complementarity, where hybridization between a target sequence and a guide sequence promotes the formation of an engineered nuclease complex. A target sequence can include any polynucleotide, such as DNA, RNA, or a DNA-RNA hybrid. A target sequence can be located in the nucleus or cytoplasm of a cell. A target sequence can be located in vitro or in a cell-free environment.

[0204] In some embodiments, formation of an engineered nuclease complex can include a guide nucleic acid hybridized to a target sequence and complexed with one or more novel engineered nucleases as disclosed herein renders cleavage of one or both strands in or near (e.g. within 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, or more base pairs from) the targeted sequence. Cleavage can occur within a target sequence, 5' of the target sequence, upstream of a target sequence, 3' of the target sequence, or downstream of a target sequence.

[0205] In some embodiments, one or more vectors driving expression of one or more components of a targetable nuclease system are introduced into a host cell or in vitro such formation of a targetable nuclease complex at one or more target sites. For example, a nucleic acid-guided nuclease and a guide nucleic acid can each be operably linked to separate regulatory elements on separate vectors. Alternatively, two or more of the elements expressed from the same or different regulatory elements, can be combined in a single vector, with one or more additional vectors providing any components of the targetable nuclease system not included in the first vector. Targetable nuclease system elements that are combined in a single vector may be arranged in any suitable orientation, such as one element located 5' with respect to (“upstream” of) or 3' with respect to (“downstream” of) a second element. The coding sequence of one element may be located on the same or opposite strand of the coding sequence of a second element, and oriented in the same or opposite direction. In some embodiments, a single promoter drives expression of a transcript encoding a nucleic acid-guided nuclease and one or more guide nucleic acids. In some embodiments, a nucleic acid-guided nuclease and one or more guide nucleic acids are operably linked to and expressed from the same promoter. In other embodiments, one or more guide nucleic acids or polynucleotides encoding the one or more guide nucleic acids are introduced into a cell or in vitro environment already can include a nucleic acid-guided nuclease or polynucleotide sequence encoding the nucleic acid-guided nuclease.

[0206] In some embodiments, when multiple different guide sequences are used, a single expression construct may be used to target nuclease activity to multiple different, corresponding target sequences within a cell or in vitro. For example, a single vector can include about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, or more guide sequences. In other embodiments, about or more than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more such guide-sequence-containing vectors can be provided, and optionally, delivered to a cell in vivo or in vitro.

[0207] In some embodiments, methods and compositions disclosed herein can include more than one guide nucleic acid, such that each guide nucleic acid has a different guide sequence, thereby targeting a different target sequence. In accordance with these embodiments, multiple guide nucleic acids can be using in multiplexing, wherein multiple targets are targeted simultaneously. Additionally or alternatively, the multiple guide nucleic acids are introduced into a population of cells, such that each cell in a population received a different or random guide nucleic acid, thereby targeting multiple different target sequences across a population of cells. In such cases, the collection of subsequently altered cells can be referred to as a library.

[0208] In other embodiments, methods and compositions disclosed herein can include multiple different nucleic acid-guided nucleases, each with one or more different corresponding guide nucleic acids, thereby allowing targeting of different target sequences by different nucleic acid-guided nucleases. In some such cases, each nucleic acid-guided nuclease can correspond to a distinct plurality of guide nucleic acids, allowing two or more non-overlapping, partially overlapping, or completely overlapping multiplexing events.

[0209] In some embodiments, the nucleic acid-guided nuclease has DNA cleavage activity or RNA cleavage activity. In some embodiments, the nucleic acid-guided nuclease directs cleavage of one or both strands at the location of a target sequence, such as within the target sequence and/or within the complement of the target sequence. In some embodiments, the nucleic acid- guided nuclease directs cleavage of one or both strands within about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,

15, 20, 25, 50, 100, 200, 500, or more base pairs from the first or last nucleotide of a target sequence.

[0210] In certain embodiments, the invention provides for methods of modifying a target sequence in vitro, or in a prokaryotic or eukaryotic cell, which can be in vivo, ex vivo, or in vitro. In some embodiments, the method includes sampling a cell or population of cells such as prokaryotic cells, or those from a human or non-human animal or plant (including micro-algae or other organism), and modifying the cell or cells. Culturing may occur at any stage in vitro or ex vivo. The cell or cells may even be re-introduced into the host, such as a non-human animal or plant (including micro-algae). For re-introduced cells, they can be stem cells.

[0211] In some embodiments, the method includes allowing a targetable nuclease complex to bind to the target sequence to effect cleavage of the target sequence, thereby modifying the target sequence, wherein the targetable nuclease complex includes a nucleic acid-guided nuclease complexed with a guide nucleic acid wherein the guide sequence of the guide nucleic acid is hybridized to a target sequence within a target polynucleotide. In some aspects, the invention provides a method of modifying expression of a target polynucleotide in in vitro or in a prokaryotic or eukaryotic cell. In some embodiments, the method includes allowing an targetable nuclease complex to bind to a target sequence with the target polynucleotide such that the binding can lead to in increased or decreased expression of the target polynucleotide; wherein the targetable nuclease complex includes an nucleic acid-guided nuclease complexed with a guide nucleic acid, and wherein the guide sequence of the guide nucleic acid is hybridized to a target sequence within the target polynucleotide.

[0212] In certain embodiments, the invention provides kits containing any one or more of the elements disclosed in the above methods and compositions. Elements may provide individually or in combinations, and may be provided in any suitable container, such as a vial, a bottle, or a tube. In some embodiments, the kit includes instructions in one or more languages, for example in more than one language.

[0213] In some embodiments, a kit comprises one or more reagents for use in a process utilizing one or more of the elements described herein. Reagents may be provided in any suitable container. For example, a kit may provide one or more reaction or storage buffers. Reagents can be provided in a form that is usable in an assay, or in a form that requires addition of one or more other components before use (e.g. in concentrate or lyophilized form). A buffer can be any buffer, including but not limited to a sodium carbonate buffer, a sodium bicarbonate buffer, a borate buffer, a Tris buffer, a MOPS buffer, a HEPES buffer, and combinations thereof. In some embodiments, the buffer is alkaline. In some embodiments, the buffer has a pH from about 7 to about 10. In some embodiments, the kit includes one or more oligonucleotides corresponding to a guide sequence for insertion into a vector so as to operably link the guide sequence and a regulatory element. In some embodiments, the kit includes a editing template.

[0214] In some embodiments, a targetable nuclease complex has a wide variety of utility including modifying (e.g., deleting, inserting, translocating, inactivating, activating) a target sequence in a multiplicity of cell types. As such a targetable nuclease complex of the invention has a broad spectrum of applications in, e.g., biochemical pathway optimization, genome-wide studies, genome engineering, gene therapy, drug screening, disease diagnosis, and prognosis. An exemplary targetable nuclease complex includes a nucleic acid-guided nuclease as disclosed herein complexed with a guide nucleic acid, wherein the guide sequence of the guide nucleic acid can hybridize to a target sequence within the target polynucleotide. A guide nucleic acid can include a guide sequence linked to a scaffold sequence. A scaffold sequence can include one or more sequence regions with a degree of complementarity such that together they form a secondary structure.

[0215] An editing template polynucleotide can include a sequence to be integrated (e.g., a mutated gene). A sequence for integration may be a sequence endogenous or exogenous to the cell. Examples of a sequence to be integrated include polynucleotides encoding a protein or a non-coding RNA (e.g., a microRNA). Thus, the sequence for integration may be operably linked to an appropriate control sequence or sequences. Alternatively, the sequence to be integrated may provide a regulatory function. Sequence to be integrated may be a mutated or variant of an endogenous wild-type sequence. Alternatively, sequence to be integrated may be a wild-type version of an endogenous mutated sequence. Additionally or alternatively, sequenced to be integrated may be a variant or mutated form of an endogenous mutated or variant sequence. [0216] In certain embodiments, an upstream or downstream sequence can include from about 20 bp to about 2500 bp, for example, about 50, 100, 200, 300, 400, 500, 600, 700, 800, 900,

1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, or about 2500 bp. In some embodiments, an exemplary upstream or downstream sequence has about 15 bp to about 2000 bp, about 30 bp to about 1000 bp, about 50 bp to about 750 bp, about 600 bp to about 1000 bp, or about 700 bp to about 1000 bp.

[0217] In some embodiments, the editing template polynucleotide can further include a marker. In certain embodiments, some markers can facilitate screening for targeted integrations. Examples of suitable markers can include, but are not limited to, restriction sites, fluorescent proteins, or selectable markers. In certain embodiments, an exogenous polynucleotide template can be constructed using recombinant techniques.

[0218] In one embodiment, an exemplary method for modifying a target polynucleotide by integrating an editing template polynucleotide, a double stranded break is introduced into the genome sequence by an engineered nuclease complex, the break can be repaired via homologous recombination using an editing template such that the template is integrated into the target polynucleotide. The presence of a double-stranded break can increase the efficiency of integration of the editing template.

[0219] Disclosed herein are methods for modifying expression of a polynucleotide in a cell. Some methods include increasing or decreasing expression of a target polynucleotide by using a targetable nuclease complex that binds to the target polynucleotide.

[0220] Detection of the gene expression level can be conducted in real time in an amplification assay. In one aspect, the amplified products can be directly visualized with fluorescent DNA-binding agents including but not limited to DNA intercalators and DNA groove binders. Because the amount of the intercalators incorporated into the double-stranded DNA molecules can be proportional to the amount of the amplified DNA products, one can conveniently determine the amount of the amplified products by quantifying the fluorescence of the intercalated dye using conventional optical systems in the art. DNA-binding dye suitable for this application include, but are not limited to, SYBR green, SYBR blue, DAPI, propidium iodine, Hoeste, SYBR gold, ethidium bromide, acridines, proflavine, acridine orange, acriflavine, fluorcoumanin, ellipticine, daunomycin, chloroquine, distamycin D, chromomycin, homidium, mithramycin, ruthenium polypyridyls, anthramycin, and others known by one of skill in the art. [0221] In some embodiments, other fluorescent labels such as sequence specific probes can be employed in the amplification reaction to facilitate the detection and quantification of the amplified products. Probe-based quantitative amplification relies on the sequence-specific detection of a desired amplified product. It utilizes fluorescent, target-specific probes (e.g., TaqMan™ probes) resulting in increased specificity and sensitivity. Methods for performing probe-based quantitative amplification are well established in the art.

[0222] In some embodiments, an agent-induced change in expression of sequences associated with a signaling biochemical pathway can also be determined by examining the corresponding gene products. Determining the protein level can involve a) contacting the protein contained in a biological sample with an agent that specifically bind to a protein associated with a signaling biochemical pathway; and (b) identifying any agentprotein complex so formed. In one aspect of this embodiment, the agent that specifically binds a protein associated with a signaling biochemical pathway is an antibody, preferably a monoclonal antibody.

[0223] In some embodiments, the amount of agentpolypeptide complexes formed during the binding reaction can be quantified by standard quantitative assays. As illustrated above, the formation of agentpolypeptide complex can be measured directly by the amount of label remained at the site of binding. In an alternative, the protein associated with a signaling biochemical pathway is tested for its ability to compete with a labeled analog for binding sites on the specific agent. In this competitive assay, the amount of label captured is inversely proportional to the amount of protein sequences associated with a signaling biochemical pathway present in a test sample.

[0224] In some embodiments, a number of techniques for protein analysis based on the general principles outlined above are known in the art and contemplated herein. They include but are not limited to radioimmunoassays, ELISA (enzyme linked immunoradiometric assays), “sandwich” immunoassays, immunoradiometric assays, in situ immunoassays (using e.g., colloidal gold, enzyme or radioisotope labels), western blot analysis, immunoprecipitation assays, immunofhiorescent assays, and SDS-PAGE. [0225] In some embodiments, in practicing a subject method, it may be desirable to discern the expression pattern of a protein associated with a signaling biochemical pathway in different bodily tissue, in different cell types, and/or in different subcellular structures. These studies can be performed with the use of tissue-specific, cell-specific or subcellular structure specific antibodies capable of binding to protein markers that are preferentially expressed in certain tissues, cell types, or subcellular structures.

[0226] In other embodiment, an altered expression of a gene associated with a signaling biochemical pathway can also be determined by examining a change in activity of the gene product relative to a control cell. The assay for an agent-induced change in the activity of a protein associated with a signaling biochemical pathway will dependent on the biological activity and/or the signal transduction pathway that is under investigation. For example, where the protein is a kinase, a change in its ability to phosphorylate the downstream substrate(s) can be determined by a variety of assays known in the art. Representative assays include but are not limited to immunoblotting and immunoprecipitation with antibodies such as anti- phosphotyrosine antibodies that recognize phosphorylated proteins. In addition, kinase activity can be detected by high throughput chemiluminescent assays.

[0227] In certain embodiments, where the protein associated with a signaling biochemical pathway is part of a signaling cascade leading to a fluctuation of intracellular pH condition, pH sensitive molecules such as fluorescent pH dyes can be used as the reporter molecules. In another example where the protein associated with a signaling biochemical pathway is an ion channel, fluctuations in membrane potential and/or intracellular ion concentration can be monitored. A number of commercial kits and high-throughput devices are suited for a rapid and robust screening for modulators of ion channels. Representative instruments include FLIPR™ (Molecular Devices, Inc.) and VIPR (Aurora Biosciences). These instruments are capable of detecting reactions in over 1000 sample wells of a microplate simultaneously, and providing real time measurement and functional data within a second or even a millisecond.

[0228] In practicing any of the methods disclosed herein, a suitable vector can be introduced to a cell, tissue, organism, or an embryo via one or more methods known in the art, including without limitation, microinjection, electroporation, sonoporation, biolistics, calcium phosphate- mediated transfection, cationic transfection, liposome transfection, dendrimer transfection, heat shock transfection, nucleofection transfection, magnetofection, lipofection, impalefection, optical transfection, proprietary agent-enhanced uptake of nucleic acids, and delivery via liposomes, immunoliposomes, virosomes, or artificial virions. In some methods, the vector is introduced into an embryo by microinjection. The vector or vectors may be microinjected into the nucleus or the cytoplasm of the embryo. In some methods, the vector or vectors may be introduced into a cell by nucleofection.

[0229] A target polynucleotide of a targetable nuclease complex can be any polynucleotide endogenous or exogenous to the host cell. For example, the target polynucleotide can be a polynucleotide residing in the nucleus of the eukaryotic cell, the genome of a prokaryotic cell, or an extrachromosomal vector of a host cell. The target polynucleotide can be a sequence coding a gene product (e.g., a protein) or a non-coding sequence (e.g., a regulatory polynucleotide or a junk DNA).

[0230] Some embodiments disclosed herein relate to use of an engineered nucleic acid guided nuclease system disclosed herein; for example, in order to target and knock out genes, amplify genes and/or repair certain mutations associated with DNA repeat instability and a medical disorder. This nuclease system may be used to harness and to correct these defects of genomic instability. In other embodiments, engineered nucleic acid guided nuclease systems disclosed herein can be used for correcting defects in the genes associated with Lafora disease. Lafora disease is an autosomal recessive condition which is characterized by progressive myoclonus epilepsy which may start as epileptic seizures in adolescence. This condition causes seizures, muscle spasms, difficulty walking, dementia, and eventually death.

[0231] In yet another aspect of the invention, the engineered/novel nucleic acid guided nuclease system can be used to correct genetic-eye disorders that arise from several genetic mutations

[0232] In certain embodiments disclosed herein engineered nucleic acid guided nuclease constructs can recognize a protospacer adjacent motif (PAM) sequence other than TTTN or in addition to TTTN. In other embodiments, engineered nucleic acid guided nuclease constructs disclosed herein can be further mutated to improve targeting efficiency or can be selected from a library for certain targeted features. Other embodiments disclosed herein concern vectors including constructs disclosed herein of use for further analysis and to select for improved genome editing features.

[0233] Other embodiments disclosed herein include kits for packaging and transporting nucleic acid guided nuclease constructs and/or novel gRNAs disclosed herein or known gRNAs disclosed herein and further include at least one container. In certain embodiments, several reagents required for the kits can be included for convenience and ease of transport and efficiency.

EXAMPLES

Example 1: Culture of Jurkat human T-cell leukemia cell line and primary human T-cells [0234] Human Jurkat T-cell leukemia cells (Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH (ACC 282)) were propagated in RPMI 1640 medium (ThermoFisher Scientific) with 10% heat-inactivated fetal bovine serum (FBS) (ThermoFisher Scientific) supplemented with 1% penicillin-streptomycin antibiotic mix (ThermoFisher Scientific). Cells were cultured at 37°C in 5% C02 incubators and maintained at a density of 0.5 to 1.5xl0 ⁶ cells mL ¹ . 24 hours before transfection, cells were passaged at 0. lxlO ⁶ cell mL ¹ . Cell culture media supernatant was periodically tested for mycoplasma contamination using the MycoAlert PLUS mycoplasma detection kit (Lonza).

Example 2: Primary T-cell isolation and culture

[0235] T-cells were isolated from human peripheral blood obtained from healthy adults by immune-magnetic negative selection using the EasySep Human T-cell Isolation Kit (STEMCELL Technologies). After isolation, T-cells were activated in 25 pL mL ¹ ImmunoCult Human CD3/CD28/CD2 T-Cell Activator (STEMCELL Technologies) in ImmunoCult-XF T- Cell Expansion Medium (STEMCELL Technologies) containing 12.5 ng mL ¹ Human Recombinant IL-2, 5 ng mL ¹ IL-7, and 5 ng mL ¹ IL-15 (STEMCELL Technologies) and seeded at l.OxlO ⁶ cells mL ¹ . Until transfection 48 hours later, the cells were cultured at 37°C in 5%

C02 incubators.

Example 3: RNP formulation

[0236] Ribonucleoprotein complexes (RNPs) were generated by incubating respective guide nucleic acids (gNAs) with MAD7 in the molar ratio of 3:2 gNA:MAD7 for 15 minutes at room temperature immediately before transfection. For Jurkat experiments, the RNP complexes were generated by mixing the respective gNA (150 pmol), MAD7 (100 pmol), and nuclease-free water, unless otherwise stated. For T-cell experiments, 1.6 pL of an aqueous solution of 15-50 kDa poly-L-glutamic acid (PGA, 100 pg pL ¹ , Alamanda Polymers) was added to gNAs, followed by the addition of MAD7 and nuclease-free water.

Example 4: Generation of donor templates via PCT amplification

[0237] Donor templates comprising site-specific homology arms, respective promoter, and respective gene (GFP or Hul9 8ϋRn-O08a-uq28-uΏ3z CAR) were amplified from corresponding pTwist Ampicillin high-copy plasmids (Twist Bioscience) using homology arms- specific PCR primers. Donor templates were amplified in a two-step PCR program: initial denaturation at 98°C for 30 seconds, cycle denaturation at 98°C for 10 seconds, extension at 72°C for 30 seconds per kb amplicon for 40-cycles with a hold at 72°C for 10 minutes. Each 50 pL PCR reaction contained 10 ng amplification template (plasmid DNA), 0.5 mM homology arm-specific forward and reverse primers, nuclease-free water (IDT), 3% DMSO, and lx Phusion High-Fidelity PCR Master Mix with HF Buffer (ThermoFisher Scientific). PCR products were purified using NucleoSpin Gel and PCR Clean-up Kit (Macherey -Nagel) with two 20 pL elutions. Purified HDR templates were collected and quantified on NanoDrop One Microvolume UV-Vis Spectrophotometer (ThermoFisher Scientific). Templates were concentrated using Amicon Ultra 0.5 mL 30K Centrifugal Filters: 100 pg DNA per unit was transferred, filled with nuclease-free water to 500 pL, and centrifuged at 10,000 g for 10 minutes to reduce volume to 50 pL. DNA was washed twice with nuclease-free water and recovered into a fresh tube by inversion and centrifugation at 10,000 g for 15 seconds. HDR templates were collected, diluted, and concentrations quantified using Qubit dsDNA HS Assay Kit (ThermoFisher Scientific). HDR templates of 0.5 to 1 pg pL ¹ were used for cellular studies.

Example 5: Jurkat cell transfection

[0238] Lonza 4D Nucleofector with Shuttle unit (V4SC-2960 Nucleocuvette Strips) was used for transfection, following the manufacturer’s instructions. For transfection, cells were harvested by centrifugation (200 g, RT, 5 minutes) and re-suspended in 20 pL at lOxlO ⁶ cells mL ¹ in the SF Cell Line Nucleofector X Kit buffer (Lonza), unless stated otherwise. The cell suspension was mixed with the RNPs, immediately transferred to the nucleocuvette, and transfected. After transfection, the cells were immediately re-suspended in the pre-warmed cultivation medium and plated onto 96-well, flat-bottom, non-cell culture treated plates (Falcon), and cultured at 37°C in 5% CO2 incubators and maintained at a density of 0.5 to LOxlO ⁶ cells mL ¹ . After 48 hours, the cells were harvested for the viability assay and genomic DNA, as described below. For the Homology-Directed Repair Template insertion, the HDR template was added to the cells and the suspension transferred to the RNPs immediately before transfection. The transfection parameters, cell recovery step, and proliferation conditions as described in Example 1. The cells were harvested 48 hours post-transfection for the viability assessment, after 7 days for CAR insertion efficiency, or after 7 days, 14 days, and 21 days for GFP insertion efficiency.

Example 6: Primary T-cell transfection

[0239] 48 hours after isolation, the cells were harvested by centrifugation (300 g, RT, 5 minutes) and re-suspended in 20 pL at 50xl0 ⁶ cells mL ¹ in the supplemented P3 Primary Cell Nucleofector Kit buffer (Lonza). The cells were mixed with HDR templates and the suspension transferred to the RNPs immediately before transfection (Nucleofection program EH-115). After transfection, 80 pL of pre-warmed cultivation medium without IL-2 was added to the electroporation cuvettes. When using M3814 (Selleckchem), 80 pL of pre-warmed cultivation medium containing 2 pM M3814 final concentration without IL-2 was added to the electroporation cuvettes. After 10 minutes of incubation at 37°C, T-cells were transferred onto 96-well, flat-bottom, non-cell culture treated plates (Falcon) containing pre-warmed cultivation medium pretreated with 2 pM M3814 final concentration and 12.5 ng mL ¹ IL-2. The cells were seeded at a density of 0.25xl0 ⁶ cells mL ¹ , or 1.3xl0 ⁶ cells mL ¹ in the experiment with M3814, and kept at 37°C in 5% CO2 incubators. The viability assay was carried out 24 hours post transfection after which the cells were reseeded in the fresh cultivation medium containing IL-2. Insertion efficiency of CAR was measured after 7 days, and 11 days or 13 days post-transfection. Example 7: Flow cytometry

[0240] Flow cytometric assessments were carried out on a CytoFLEX S instrument (Beckmen Coulter) using a 96-well plate format. Measurements of cell viability, PDCD1 expression, GFP expression, and CAR expression were performed on 10,000 or 20,000 single cell events in Jurkat or primary T-cells, respectively.

[0241] For the cell viability and GFP knock-in measurements, approximately 250,000 cells per sample were transferred onto 96-well V-bottom cell culture plates and assessed following a series of consecutive washing and staining steps. The first step included centrifuging the cells at 300 g for 5 minutes at room temperature, discarding the supernatant, and washing cells in 150 pL Dulbecco’s PBS/2% FBS (STEMCELL Technologies) or Cell Staining Buffer (Biolegend), respectively, followed by the second centrifugation and removal of supernatant. The final step included viability staining of cells using 150 pL Dulbecco’s PBS/2% FBS with 7-amino- actinomycin D (7-AAD, 1:1,000; ThermoFisher) or 50 pL Cell Staining Buffer with Zombie Violet Dye (1:200; Biolegend), respectively. The measurements of cell viability and GFP expression were collected simultaneously for 7-AAD (excitation: yellow-green laser; emission: 561 nm), Zombie Violet (excitation: violet laser; emission 405 nm), and GFP (excitation: blue laser; emission 488 nm) as needed.

[0242] For detection of CAR knock-in efficiency, approx. 250,000 cells per sample were transferred onto 96-well V -bottom, washed as described above using Cell Staining Buffer, and re-suspended in 50 pL Cell Staining Buffer with PE Anti-Myc tag antibody [9E10] (1:50; Abeam) and Zombie Violet Dye (1:200; Biolegend) for 30 minutes. Afterwards, the cells were washed in two subsequent washing steps using 150 pL Cell Staining Buffer, and finally re suspended in 100 pL Cell Staining Buffer for the flow cytometry measurements (excitation: yellow-green laser; emission: 561 nm).

[0243] For detection of PDCD1 knock-out efficiency, approx. 250,000 Jurkat cells per sample were transferred onto 96-well V-bottom cell culture plates and assessed following a series of consecutive washing and staining steps. The first step included centrifuging the cells at 300 g for 5 minutes at 4°C and discarding the supernatant. Afterwards, the cells were stained using 100 pL Cell Staining Buffer (Biolegend) with APC/Cyanine7 anti-human CD279 (PD-1) antibody (1: 100; Biolegend) and incubated for 30 minutes at 4°C in the dark. The cells were then centrifuged at 300 g for 5 minutes at 4°C and the supernatant discarded. The next step included two repeats of centrifugation at 300 g for 5 minutes at 4°C, supernatant removal, and cell washing in 150 pL ice-cold Cell Staining Buffer (Biolegend). In the final step, the cells were re suspended in 100 pL Cell Staining Buffer for the flow cytometry measurements (excitation: red laser; emission: 633 nm).

Example 8: DNA extraction

[0244] Cells were harvested 48-h post-transfection by centrifugation (1,000 g, 10 minutes) in 96-well, V-bottom plates (Greiner), washed with PBS (Sigma Aldrich) and lysed in 20 pL QuickExtract DNA Extraction Solution (Epicentre, Lucigen). DNA was extracted following the manufacturer’s protocol: 15 minutes at 65°C, 15 minutes at 68°C, 10 minutes at 95°C, cooled to 4°C, and stored at 4°C. Genomic DNA was diluted 20-fold in nuclease-free water before amplicon PCR reactions.

Example 9: Amplicon sequencing

[0245] Extracted genomic DNA was quantified using the NanoDrop (ThermoFisher Scientific). Amplicons were constructed in two PCR steps: in the first PCR, regions of interest (150-400 bp) were amplified from 10 to 30 ng of genomic DNA with primers containing Illumina forward and reverse adapters on both ends comprising suitable loci-specific complementary sequences, using Phusion High-Fidelity PCR Master Mix (ThermoFisher Scientific). Amplification products were purified with Agencourt AMPure XP beads (Ramcon), using the sample to beads ratio of 1: 1.8. The DNA was eluted from the beads with nuclease-free water and the size of the purified amplicons analyzed on a 2% agarose E-gel using the E-gel electrophoresis system (ThermoFisher Scientific). In the second PCR, unique pairs of Illumina- compatible indexes (Nextera XT Index Kit v2) were added to the amplicons using the KAPA HiFi HotStart Ready Mix (Roche). The amplified products were purified with Agencourt AMPure XP beads (Ramcon), using the sample to bead ratio of 1: 1.8. The DNA was eluted from the beads with 10 mM Tris-HCl pH 8.5, 0.1% Tween 20. Sizes of the purified DNA fragments were validated on a 2% agarose gel using the E-gel electrophoresis system (ThermoFisher Scientific), quantified using Qubit dsDNA HS Assay Kit (Thermo Fisher) and then pooled in equimolar concentrations. Quality of the amplicon library was validated using Bioanalyzer, High Sensitivity DNA Kit (Agilent) before sequencing. The final library was sequenced on Illumina MiSeq System using the MiSeq Reagent Kit v.2 (300 cycles, 2x250 bp, paired-end reads). De multiplexed FASTQ files were obtained from BaseSpace (Illumina).

Example 10: NGS data analysis

[0246] Initial quality assessment of the obtained reads was performed with FastQC36. The sequencing data were aligned and analyzed with the CRISPResso2 software, using CRISPRessoBatch command with the parameters -cleavage offset 1 — quantification window size 10 - --quantification window center 1 - expand ambiguous alignments for the INDEL frequency analysis. For the ORF disruption analysis, CRISPRessoBatch command with the parameters -cleavage offset 1 -coding seq <EXON_SEQ> -quantification window size 0 -quantification window center 1 - expand ambiguous alignments was used. Modification rates from the CRISPResso2 software output were analyzed in Excel.

Example 11: CRISPR-MAD7 platform for human genome editing using the Jurkat T-cell leukemia line

[0247] MAD7 nuclease comprising a His6 tag and either one (MAD7-1NLS) or four (MAD7-4NLS) nuclear localization signals (NLS) were used (Figure 1). RNPs were generated as described in Example 3. Editing frequency of the MAD7 nuclease complexed with one or more guide nucleic acids comprising a spacer sequence of SEQ ID NOs: 86-384 as shown in Table 1 was determined by nucleofection of RNPs in Jurkat T-cells using the Lonza recommended nucleofection program SE-CL-120 (Example 5), followed by genomic DNA extraction (Example 8), amplification of the edited locus and targeted next-generation sequencing (Example 9) for identification of the edits, and finally by computational analysis (Example 10) of modification frequency using the CRISPResso2 algorithm.

TABLE 1: Spacer sequences

[0248] Firstly, using a gNA targeting the DNMT1 locus, the editing frequency of MAD7 comprising either one or four NLS complexed with the respective gNA was compared. RNP concentration-dependent modification efficiency was observed as evidenced by an increased fraction of modified amplicons (Figure 2, left axis, dark grey for MAD7-1NLS and light grey representing MAD7-4NLS). Error bars represent one standard deviation for a sample of 3 (n=3). In this experiment, editing frequency was enhanced in Jurkat cells when treated with RNPs comprising MAD-4NLS, which indicates that optimization of the NLS can improve editing efficiency. A slight decrease in cell viability was seen at higher concentrations of RNP for those comprising four NLS as compared to one NLS (Figure 2, right axis). Specifically, Figure 2 shows editing frequency at the DNMT1 locus (n=3; Mean ± SD) and cell viability of T-cell leukemic cells as a function of MAD7 comprising one or four nuclear localization signal (NLS) and MAD7-RNP amounts (pmol; constant ratio of 1: 1.5 MAD7:gNA). Dark grey bars and circles represent mean modification frequency and viability using MAD7-1NLS, respectively. Light grey bars and triangles represent mean modification frequency and viability using MAD7-4NLS, respectively.

[0249] To optimize editing activity, 93 different transfection conditions were tested; 31 nucleofection programs in combination with three buffers - on the Lonza Nucleofector 96-well Shuttle System (Figures 3-5). Figures 3, 4, and 5 show the editing frequency (bars; x-axis) of each of the electroporation conditions (buffers SE, SF, and SG respectively) as compared to a control (y-axis, control at the top). The majority of buffer-program transfection combinations resulted in suboptimal viability (dots; x-axis) and editing frequency, however, the analysis revealed several conditions that supported substantial rates of both cell viability and editing. Two improved conditions observed in the screen, namely SF-CA-137 and SG-CA-138, were then validated and compared to the Lonza recommended nucleofection programs for T-cell leukemia, namely SE-CL-120 and SE-CK-116 (Figure 6). Specifically, Figure 6 shows editing frequency at the DNMT1 locus (n=4; Mean ± SD) in T-cell leukemic cell line achieved by utilization of the transfection conditions identified in Figure 2 (100 pmol MAD7-4NLS) and Lonza recommended nucleofection programs SE-CK-116 and SE-CL-120, as well as the two best nucleofection programs observed in this study, SF-CA-137 and SG-CA-138 (Figures 3-5). Dark grey bars represent mean modification frequency using crDNMT 1. Light grey bars represent mean modification frequency using crIDTneg (Integrated DNA Technologies, IDT).

Example 12: Scalable high-level MAD7-RNP editing of immunologically relevant genes in Jurkate T-cell leukemia cell line

[0250] The Jurkat T-cell leukemia cell line was used as a model system to screen GNAs demonstrating high editing efficiency. The screen included 298 unique gNAs comprising one or more spacer sequences of SEQ ID NOs: 86-384 of Table 1 targeting the immune checkpoint receptors PDCD1, TIM3, LAG3, TIGIT, and CTLA4, the checkpoint phosphatases PTPN6 (SHP-1) and PTPN11 (SHP-2), and the TCR signaling subunit CD247 (Oϋ3z). RNPs were generated as described in Example 3, nucleofected (Example 5), genomic DNA was extracted (Example 8), the edited loci amplified and sequenced (Example 9), and the sequencing data computationally analyzed (Example 10) using the CRISPResso2 algorithm.

[0251] CRISPResso2 software reports the frequency of modifications (insertions, deletions, and substitutions) within a quantification window flanking the position of MAD7-induced cleavage in the amplicon sequence. To better understand detection of editing events, the type of modifications detected in 230 amplicons that were sequenced in both gNA-treated and MOCK samples (no MAD7) were compared. Relatively high modification frequencies (median 1%) in MOCK reactions were observed as a result of high frequency of substitutions (Figure 7, light grey bars); substitutions were detected at a median frequency of 0.96%, likely due to the errors in NGS base calling or substitutions arising during DNA amplification, while insertions and deletions were found at a much lower median frequency of 0.003% and 0.042%, respectively. Specifically, Figure 7 shows editing frequency at eight different loci using 298 gNAs (n=3;

Mean ± SD) in T-cell leukemic cell line as a function of various editing types: all modifications, only insertions, only deletions, only substitutions, or insertions and deletions (INDELs). Edits were achieved using the transfection conditions identified in Example 11, Figure 2(100 pmol MAD7-4NLS) and one of the tested Lonza nucleofection programs (Figure 6; SF-CA-137).

Dark grey boxplots represent mean modification frequency using gNAs. Light grey boxplots represent mean modification frequency using crIDTneg (IDT). Thus, the frequency of both insertions and deletions (INDEL) were used as a means to quantify the editing activity of the CRISPR-MAD7 system to minimize low end noise. Moreover, low INDEL frequencies in MOCK reactions enabled sensitive detection of editing events at a significantly greater fraction of sites (Fisher exact test, P=3xl0 ¹² ; Figure 8). Analysis of gNAs with low INDEL frequencies showed statistically significant editing in gNA-treated samples compared to MOCK samples at INDEL frequencies as low as 0.5% (Fisher exact test, P=4xl0 ⁸ ; Figure 8). This indicates the sensitivity of the assay to detect modifications in the sub-1% range. Specifically, Figure 8 shows INDEL frequency at eight different loci using 298 gNAs (n=3; Mean ± SD) in T-cell leukemic cell line as a function of two modification types: all modifications <1%, and INDELs <1%, or <0.5%, or <0.1%, with lower INDEL frequencies in MOCK compared to gNA reactions at INDELs <1% (Fisher’s exact test; P=3xl0 ¹² ) and <0.5% (Fisher exact test, P=4xl0 ⁸ ). Dark grey boxplots represent mean INDEL frequency using gNAs. Light grey boxplots represent mean INDEL frequency using crIDTneg (IDT).

[0252] Since MAD7 can target a wide range of PAM, gNAs adjacent to all YTTN PAM variants were screened and editing specificity of MAD7 in Jurkat cells was analyzed. MAD7 demonstrated editing with all eight combinations of YTTN PAM; in this experiment, editing was higher at the YTTV and TTTV consensus sequences (Fisher exact test; P=2xl0 ³ and P=2xl0 ⁴ , respectively). While the majority of highly-active (>50% INDEL frequency) gNAs were found at sites with YTTV and TTTV PAMs, moderately-active (>10% INDEL frequency) gNAs were found to target every PAM sequence with the exception of CTTT. This indicates that MAD7 can edit a wide range of target PAMs, albeit at reduced frequencies (Figure 9). Specifically, Figure 9 shows INDEL frequency at eight different loci using 298 gNAs (n=3; Mean ± SD) in T-cell leukemic cell line as a function of eight YTTN PAM combinations, and TTTV, YTTN, and YTTV PAM motifs. A grey zone on the plot represents moderately-active gNAs (10-50% INDELs), the zone above highly-active gNAs (>50% INDELs), and the zone below active gNAs (1-10% INDELs). INDEL frequency at the YTTV and TTTV PAM motif is significantly higher compared to YTTN motif (Fisher exact test, P=2xl0 ³ and P=2xl0 ⁴ , respectively).

[0253] Given the large number of gNAs analyzed, it was determined if the targeted DNA sequence biases editing efficiency. Sequence logos were made to compare the DNA- complementary gNA sequences of inactive (<1% INDELs), active (1-10% INDELs), moderately-active (10-50% INDELs), and highly-active (>50% INDELs) gNAs (Figure 10A). While no strong biases for ribonucleotides at specific positions were identified in this experiment, guanine appeared overrepresented and uracil underrepresented on moderately-active and highly-active gNAs. Next, the frequency of ribonucleotide bases were analyzed within the same four classes of gNAs (Figure 10B). The analysis confirmed significant enrichment of guanine and depletion of uracil on highly-active gNAs. Specifically, Figure 10 shows (A) sequence logos comparing DNA-complementary gNA sequences of highly-active (>50% INDELs), moderately-active (10-50% INDELs), active (1-10% INDELs), and inactive (<1% INDELs) gNAs show no strong biases for ribonucleotides at specific positions, however, guanine appeared overrepresented and uracil underrepresented on highly-active and moderately-active gNAs; (B) nucleotide frequency on inactive (<1% INDELs; dark grey box), active (1-10% INDELs; medium grey box), moderately-active (10-50% INDELs; light grey box), and highly- active (>50% INDELs; white box) gNAs, with significant enrichment of guanine and depletion of uracil on highly-active gNAs compared to inactive gNAs (Fisher exact test, P=4xl0 ³ and P=3xl0 ⁴ , respectively). Also, significant enrichment of guanine-cytosine content and depletion of adenine -uracil content was observed on moderately-active gNAs compared to inactive gNAs (Fisher exact test, P=lxl0 ² ). Moreover, the data showed that nearly 40% of inactive gNAs had runs of three or more adenine or uracil ribonucleotides, while none of the highly-active and <20% of moderately-active gNAs contained such runs (Figure 11). These sequence features can act as an algorithm for selecting putative high-activity gNAs during initial rounds of screening, and could reduce the overall cost of identifying gNAs for various genes of interest. Specifically, Figure 11 shows fraction of gNAs with AAA and/or UUU runs as a function of INDEL frequency of highly-active (>50% INDELs), moderately-active (10-50% INDELs), active (1- 10% INDELs), and inactive (<1% INDELs) gNAs. Fraction of inactive (<1% INDELs) and active (1-10% INDELs) gNAs containing such runs is higher compared to highly-active (>50% INDELs) gNAs (Fisher exact test, P=lxl0 ³ and P=4xl0 ⁴ , respectively). Example 13: Validation of gNAs for gene editing and disruption of immunologically relevant genes using T-cell leukemia line

[0254] High-efficiency gNAs identified in our initial analysis were validated by assaying INDEL frequency for the top three or five gNAs for each of the selected immunologically relevant genes (Figure 12). Specifically, Figure 12 shows INDEL (dark grey bars) and frameshift (light grey bars) frequencies (n=3; Mean ± SD) in T-cell leukemic cell line as a function of 38 high-efficiency gNAs. Alternating grey and white zones on the plot represent groups of three to five high-efficiency gNAs per locus. In the validation experiment, the INDEL frequency was significantly correlated to the measurements from the initial screen, highlighting the reproducibility of the INDEL assay (Figure 13). Specifically, Figure 13 shows correlation of INDEL frequency in the gNA validation experiment versus INDEL formation in the gNA screen experiment (Spearman’s correlation = 0.91; P=9xl0 ¹⁴ ), highlighting reproducibility of the INDEL assay. Using the CRISPresso2 software, the degree of open reading frame (ORF) disruption for each of the validated gNAs was estimated (Figure 12). In addition, for four high- efficiency gNAs targeting three different exons at the PDCD 1 locus, surface expression of the PDCD 1 protein was measured by flow cytometry 4, 7, and 11 days post-transfection (data not shown). The data revealed that the protein surface expression after transfection with crPDCDl_2, a gNA targeting the PDCD1 gene at the extracellular domain of the protein, was as low as 10% 4 days post-transfection and remained at this level even at day 11 post-transfection. The surface expression after transfection with the remaining three gNAs was significantly higher, 35% and 85% after transfection with crPDCDl_3 and both crPDCDl_4 and crPDCDl_5, respectively. This is in line with the ORF data analysis, which showed that for most of the gNAs including the high-efficiency crPDCDls, the predicted number of INDELs leading to frameshifts was similar to that expected from an unbiased DNA repair process, with frameshifts in two-thirds of the edited loci (Figure 14). However, several of the gNAs had a markedly different degree of ORF disruption; crCD247_4 resulted in frameshifts with 97% frequency, while crTIM3_l and crTIM3_3 resulted in frameshifts with 23% and 44% frequency, respectively (Figure 14). Specifically, Figure 14 shows fraction of frameshift to INDEL frequency (dark grey bars) in T- cell leukemic cell line as a function of 38 high-efficiency gNAs. Average fraction of INDELs leading to frameshifts (dashed line) is approx. 66%. Alternating grey and white zones on the plot represent groups of three to five high-efficiency gNAs per locus. The analysis of repair products indicates that in the case of crTIM3_l, and to some extent crTIM3_3, the bias arose from directly repeated sequences at the DNA cleavage site, which possibly promoted microhomology- mediated end joining (MMEJ) repair following DNA cleavage. These data help inform selection of gNAs for gene KO since some gNAs, such as crTIM3_l, have much lower frequency of gene disruption than would be predicted based on the frequency of INDEL formation.

[0255] Another consideration for selecting gNAs is the potential for off-target cleavage events. The list of validated gNAs was analyzed using the CasOFFinder software to predict potential off-target editing sites in the genome with up to four mismatches between the gNA and the target DNA sequence. Using the Bioconductor R packages, the predicted off-target sites were matched with the human gene database, and those sites that targeted exons and introns within the genes were extracted. Afterwards, the degree of editing activity at these sites was examined by targeted next-generation sequencing, more specifically, at 25 predicted off-target sites for the top-two PDCD1 gNAs, i.e., crPDCDl l and crPDCDl_2. The analysis revealed low-level off- target activity at crPDCDl_2_13 and crPDCDl_2_15 sites, however, INDEL formation at these two sites was statistically insignificant compared to MOCK samples (non-targeting gNAs) (Pairwise T-test, P>0.05; Figures 15 and 16). INDEL frequency at 43 putative off-target sites with up to three mismatches between gNA and target DNA sequence were assayed for the top- two gNAs targeting seven remaining genes (i.e., TIM3, LAG3, TIGIT, CTLA4, PTPN6, PTPN11, and CD247; spacer sequences in Table 1). The analysis revealed no detectable activity at any of the putative off-target sites (Figures 15 and 16), which confirms the high cleavage fidelity of MAD7-gNA complexes. Specifically, Figures 15-16 show INDEL frequency of MAD7 (n=3; Mean ± SD) in T-cell leukemic cell line at predicted off-target sites analyzed by targeted deep sequencing. For crPDCDl, INDEL frequency was analyzed at the putative off- target editing sites with <4 mismatches between the gNA and target DNA sequence, and with <3 mismatches on the remaining gNAs. PAM sequences and spacer sequences with mismatches marked in red are displayed next to their respective measured INDEL frequencies. No significant INDEL frequency at any of the off-target sites was detected (Pairwise T-test, P>0.05).

[0256] Insertion of exogenous transgenes is an important aspect of mammalian cell engineering. Gene insertion with CRISPR-Cas is achieved by homology-directed repair of CRISPR-induced DNA breaks using HDR-donor templates to copy exogenous genetic sequences into targeted DNA loci. Several studies indicate that HDR templates, composed of linear double stranded DNA, provide the most robust and efficient method of transgene insertion using CRISPR-Cas genome editing systems.

[0257] The Jurkat T-cell leukemia cell line was used to evaluate the transgene insertion and expression efficiency using CRISPR-MAD7 RNP complexes. A highly active gNA targeting the AAVS1 (spacer sequence in Table 1) safe-harbor locus (Figure 17) was used in combination with eight different HDR-repair templates flanked with symmetric homology arms (HA) of 500 base pairs (bp) in the amount of 0.5 pg pL ¹ . Specifically, Figure 17 shows INDEL frequency at the AAVS1 locus (n=3; Mean ± SD) in T-cell leukemic cell line as a function of MAD7-RNP amounts (pmol; constant ratio of 1: 1.5 MAD7:gNA). Dark grey bars represent mean INDEL frequency using crAAVS 1. Light grey bars represent mean modification frequency using crIDTneg (IDT). The HDR inserts comprised eight promoters (Table 2) differing in both size and promoter strength to drive GFP expression (Figure 18). When the transient GFP expression diminished at day 14 post-transfection, comparable insertion efficiencies were observed with stable GFP expressions of up to 30% using four (JET, PGK, EFla, and CAG) out of eight promoters (Figure 18), suggesting that the insert size has not affected the integration efficiency at AAVS1 in human T-cell leukemia cell line. Specifically, Figure 18 shows GFP insertion efficiency at AAVS 1 (n=3; Mean ± SD) and cell viability of T-cell leukemic cell line measured at day 14 post-transfection. HDR templates consisting of eight different promoters and flanked with symmetric homology arms of 500 base pairs in the amount of 0.5 pg pL ¹ were used. Size of promoters in base pairs: CMV, 1400; SCP, 970; CMVe-SCP, 1270; CMVmax, 1830; JET, 1100; CAG, 2600; PGK, 1410; EF-la, 2090. Dark grey bars and circles present mean insertion frequency and cell viability using crAAVS 1. Light grey bars represent mean insertion frequency and cell viability using crIDTneg (IDT).

TABLE 2 homology arm lengths (100 vs 500 bp) and HDR template amounts (0.125 pg pL ¹ , 0.25 pg pL ¹ , 0.5 pg pL ¹ , and 1 pg pL ¹ ) on the insertion efficiency was evaluated using JET and EFla promoters. Up to 30% higher integration efficiency was observed with HDR templates flanked with HA of 500 compared to 100 base pairs. Moreover, the data showed improved insertion efficiencies with increasing amounts of HDR templates flanked with either 100 or 500 base pair HA but at the same time somewhat reduced cell viability (Figure 19). Specifically, Figure 19 shows GFP insertion efficiency at AAVS 1 (n=3; Mean ± SD) in T-cell leukemic cell line measured at days 2, 7, 14, and 21 post-transfection as a function of donor template amount. No transient GFP expression was observed at day 21 post-transfection. Cell viability (black circles) was measured at day 2 post-transfection. Top panels display GFP insertion efficiencies using donor template flanked with short homology arms (100 bp HA), and bottom panels donor template flanked with long homology arms (500 bp HA). Left panels display GFP insertion efficiencies using donor template containing EF-la promoter (long, -2000 bp), and right panels donor template containing JET promoter (short, -1000 bp). Amount of donor template, represented by the gradient above the bars, increases from 0.125, 0.25, 0.5 to 1 pg pL ¹ . Dark grey bars represent mean insertion frequency using crAAVSl. Light grey bars represent mean insertion frequency using crIDTneg (IDT).

[0259] Next, using primary T-cells isolated from the human peripheral blood from three donors and a protocol selected from the experiments above, i.e., 150: 100 pmol gNA:MAD7 RNP complex together with 1 pg pL ¹ HDR template, in combination with 100 pg pL ¹ poly-L- glutamic acid (PGA), integration efficiency of a clinically relevant CAR transgene containing JET or EFla promoter flanked with HA of 100 or 500 base pairs and a bovine growth hormone derived polyadenylation sequence was analyzed. An anti-CD 19 CAR with fully human variable regions (Hul9CAR), CD8a hinge and transmembrane domains, a CD28 costimulatory domain, and uΏ3z activation domain was used. Moderate insertion efficiency at AAVS1 but stable CAR expression of up to 14% and 16% was observed using HDR templates flanked with 100 and 500 base pair HA, respectively. The normalized cell viability measured 24 h post-transfection was in same cases relatively low, ranging from 22% with JET-500-CAR, 35% with JET-100-CAR, 43% with EFla-lOO-CAR, to 55% with EFla-500-CAR (Figure 20). It is important to emphasize, that both CAR insertion efficiency and cell viability were higher in the treatment with PGA compared to the treatment without PGA (P<0.05; data not shown). Specifically, Figure 20 shows CAR insertion efficiency at AAVS 1 (D=3; n=3; Mean ± SD) in primary Pan T-cells measured at days 7 and 11 post-transfection. Cell viability was measured 24 hours post-transfection. Individual panels display CAR insertion efficiencies using donor template structure as described in Figure 19. Amount of donor template, MAD7-RNP, and PGA was 1 pg pL ¹ , 100:150 pmol MAD7:gNA, and 100 pg pL ¹ , in that order. Nucleofection program P3-EH-115 for transfection of primary T-cells was used. D represents number of biological replicas, and n number of technical replicas per D. Dark grey bars represent mean insertion frequency using crAAVSl. Light grey bars represent mean insertion frequency using crIDTneg (IDT).

[0260] Multiple parameters were reevaluated to further optimize primary T-cell viability and CAR insertion efficiencies at AAVS1. Using Pan T-cells isolated from the blood from two donors, the effect of RNP amount with 100 pg pL ¹ PGA and EFla-500-CAR template amount on CAR insertion efficiency and cell viability was tested (data not shown). Reducing the RNP amount to 75:50 pmol gNA:MAD7 RNP complex while increasing the donor template amount to 1.5 pg pL ¹ led to improved CAR insertion efficiencies without significantly affecting cell viability (P>0.05; data not shown). In addition, using the abovementioned transfection conditions in combination with the cell recovery in a post-transfection cultivation medium pretreated with 2 pM M3814 resulted in nearly 5 -times more efficient CAR insertion than other experiments (Figure 21). The optimized CRISPR-MAD7 transfection protocol resulted in CAR insertion efficiency of up to 85% 13-days post-transfection (median 65%) together with the median normalized cell viability as high as 62% 24 hours post-transfection. Specifically, Figure 21 shows CAR insertion efficiency at AAVS 1 (D=5; n=3) in primary Pan T-cells measured at day 7 post-transfection, and re-measured in two biological replicas at day 13 post-transfection (D=2; n=3). Cell viability was measured 24 hours post-transfection (D=5; n=3; Mean ± SD). Amount or concentration of donor template, MAD7-RNP, PGA, and M3814 was 1.5 pg pL ¹ , 50:75 pmol MAD7:gNA, 100 pg pL ¹ , and 2 pM, respectively. Nucleofection program P3-EH-115 for transfection of primary T-cells was used. D represents number of biological replicas, and n number of technical replicas per D. Dark grey bars represent mean insertion frequency using crAAVS 1. Light grey bars represent mean insertion frequency using crIDTneg (IDT).

Equivalents [0261] Throughout the description, where compositions are described as having, including, or comprising specific components, or where processes and methods are described as having, including, or comprising specific steps, it is contemplated that, additionally, there are compositions of the present invention that consist essentially of, or consist of, the recited components, and that there are processes and methods according to the present invention that consist essentially of, or consist of, the recited processing steps.

[0262] In the application, where an element or component is said to be included in and/or selected from a list of recited elements or components, it should be understood that the element or component can be any one of the recited elements or components, or the element or component can be selected from a group consisting of two or more of the recited elements or components.

[0263] Further, it should be understood that elements and/or features of a composition or a method described herein can be combined in a variety of ways without departing from the spirit and scope of the present invention, whether explicit or implicit herein. For example, where reference is made to a particular compound, that compound can be used in various embodiments of compositions of the present invention and/or in methods of the present invention, unless otherwise understood from the context. In other words, within this application, embodiments have been described and depicted in a way that enables a clear and concise application to be written and drawn, but it is intended and will be appreciated that embodiments may be variously combined or separated without parting from the present teachings and invention(s). For example, it will be appreciated that all features described and depicted herein can be applicable to all aspects of the invention(s) described and depicted herein.

[0264] The terms “a” and “an” and “the” and similar references in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. For example, the term “a cell” includes a plurality of cells, including mixtures thereof. Where the plural form is used for compounds, salts, or the like, this is taken to mean also a single compound, salt, or the like.

[0265] It should be understood that the expression “at least one of’ includes individually each of the recited objects after the expression and the various combinations of two or more of the recited objects unless otherwise understood from the context and use. The expression “and/or” in connection with three or more recited objects should be understood to have the same meaning unless otherwise understood from the context.

[0266] The use of the term “include,” “includes,” “including,” “have,” “has,” “having,” “contain,” “contains,” or “containing,” including grammatical equivalents thereof, should be understood generally as open-ended and non-limiting, for example, not excluding additional unrecited elements or steps, unless otherwise specifically stated or understood from the context. [0267] Where the use of the term “about” is before a quantitative value, the present invention also includes the specific quantitative value itself, unless specifically stated otherwise. As used herein, the term “about” refers to a ±10% variation from the nominal value unless otherwise indicated or inferred.

[0268] It should be understood that the order of steps or order for performing certain actions is immaterial so long as the present invention remain operable. Moreover, two or more steps or actions may be conducted simultaneously.

[0269] The use of any and all examples, or exemplary language herein, for example, “such as” or “including,” is intended merely to illustrate better the present invention and does not pose a limitation on the scope of the invention unless claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the present invention.

[0270] The invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The foregoing embodiments are therefore to be considered in all respects illustrative rather than limiting on the invention described herein.

Scope of the invention is thus indicated by the appended claims rather than by the foregoing description, and all changes that come within the meaning and range of equivalency of the claims are intended to be embraced therein.

Embodiments

[0271] In embodiment 1 provided herein is a composition comprising a nucleic acid-guided nuclease comprising a Type V CRISPR nuclease polypeptide comprising at least one nuclear localization signal (NLS) at or near the N-terminus or the C-terminus of the polypeptide. In embodiment 2 provided herein is the composition of embodiment 1 wherein the nuclease is a Type Va nuclease. In embodiment 3 provided herein is the composition of embodiment 1 or embodiment 2 wherein the Type V CRISPR nuclease polypeptide has at least 60, 70, 80, 85, 90, 95, 96, 97, 98, 99, or 100% sequence identity, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% sequence identity with SEQ ID NO: 1. In embodiment 4 provided herein is the composition of any previous embodiment wherein the Type V CRISPR nuclease polypeptide comprises two NLSs, one or both of which are at or near the N-terminus or the C-terminus of the polypeptide. In embodiment 5 provided herein is the composition of any previous embodiment wherein the Type V CRISPR nuclease polypeptide comprises three NLSs, each of which is at or near the N-terminus or the C- terminus of the polypeptide. In embodiment 6 provided herein is the composition of any previous embodiment wherein the Type V CRISPR nuclease polypeptide comprises four NLSs, each of which is at or near the N-terminus or the C-terminus of the polypeptide. In embodiment 7 provided herein is the composition of any previous embodiment wherein the Type V CRISPR nuclease polypeptide comprises at least five NLSs, each of which is at or near the N-terminus or the C-terminus of the polypeptide. In embodiment 8 provided herein is the composition of any one of embodiments 4 through 7 wherein at least two of the NLSs are at or near the N-terminus of the polypeptide. In embodiment 9 provided herein is the composition of any one of embodiments 5 through 7 wherein at least three of the NLSs are at or near the N-terminus of the polypeptide. In embodiment 10 provided herein is the composition of any one of embodiments 6 through 7 wherein at least four of the NLSs are at or near the N-terminus of the polypeptide. In embodiment 11 provided herein is the composition of embodiment 7 wherein the 5 NLSs are at or near the N-terminus of the polypeptide. In embodiment 12 provided herein is the composition of embodiment 11 comprising a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to any one of SEQ ID NOs: 109-112. In embodiment 13 provided herein is the composition of any one of embodiments 1 through 3 wherein the Type V CRISPR nuclease polypeptide comprises at least 1-30, 1-20, 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 2-30, 2-20, 2-15, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 3-30, 3-20, 3-15, 3-10, 3-9, 3-8, 3-7, 3-6, or 3-5, preferably 1-10, more preferably 2-10, even more preferably 3-10 NLSs, each of which is at or near the N-terminus or the C-terminus of the polypeptide. In embodiment 14 provided herein is the composition of any one of embodiments 4 through 11 wherein at least two of the NLSs have different nuclear localization mechanisms. In embodiment 15 provided herein is the composition of any one of embodiments 5 through 7 or 9 through 11 wherein at least three of the NLSs have different nuclear localization mechanisms. In embodiment 16 provided herein is the composition of any previous embodiment wherein one or more of the NLSs comprises an NLS of the SV40 virus large T-antigen, an NLS from nucleoplasmin, e.g. a nucleoplasmin bipartite NLS, a c-myc NLS; a hRNPAl M9 NLS; an IBB domain of importin-alpha NLS; a myoma T protein NLS; a sequence from human p53 NLS; a sequence of mouse c-abl IV NLS; a sequence of influenza virus NS 1 NLS; a sequence of Hepatitis virus delta antigen NLS; a sequence of mouse Mxl protein NLS; a sequence of human poly(ADP-ribose) polymerase NLS; a sequence of steroid hormone receptors (human) glucocorticoid NLS; and/or a sequence of EGL-13 NLS. In embodiment 17 provided herein is the composition of embodiment 16 wherein one or more of the NLSs comprises an NLS of the SV40 virus large T-antigen. In embodiment 18 provided herein is the composition of embodiment 16 wherein two or more of the NLSs comprises an NLS of the SV40 virus large T-antigen. In embodiment 19 provided herein is the composition of embodiment 17 or embodiment 18 wherein the NLS or NLSs comprises the sequence of SEQ ID NO: 5. In embodiment 20 provided herein is the composition of any one of embodiments 16 through 19 wherein one or more of the NLSs comprises an NLS from nucleoplasmin. In embodiment 21 provided herein is the composition of embodiment 20 wherein the nucleoplasmin NLS comprises the sequence of SEQ ID NO: 6. In embodiment 22 provided herein is the composition of any one of embodiments 16 through 21 wherein one or more of the NLSs comprises a c-myc NLS. In embodiment 23 provided herein is the composition of embodiment 22 wherein the c-myc NLS comprises the sequence of SEQ ID NO: 7, SEQ ID NO: 8, or SEQ ID NO: 21. In embodiment 24 provided herein is the composition of embodiment 23 wherein the c-myc NLS comprises the sequence of SEQ ID NO: 21. In embodiment 25 provided herein is the composition of any one of embodiments 16 through 24 wherein one or more of the NLSs comprises a sequence of EGL-13 NLS. In embodiment 26 provided herein is the composition of embodiment 25 wherein the EGL-13 NLS comprises the sequence of SEQ ID NO: 107. In embodiment 27 provided herein is the composition of any previous embodiment wherein the Type V CRISPR nuclease polypeptide further comprises a purification tag. In embodiment 28 provided herein is the composition of embodiment 27 wherein the purification tag is at or near the N-terminus of the nuclease polypeptide. In embodiment 29 provided herein is the composition of embodiment 27 or embodiment 28 wherein the purification tag comprises a poly-his tag, such as a Gly-6x His tag or Gly-8x His tag; short epitope tags, e.g., FLAG, hemagglutinin (HA), c-myc, T7, Glu-Glu; maltose binding protein (mbp); N-terminal glutathione S-transferase (GST); or calmodulin binding peptide (CBP) In embodiment 30 provided herein is the composition of embodiment 29 wherein the purification tag comprises a poly-his tag. In embodiment 31 provided herein is the composition of embodiment 30 wherein the purification tag comprises a gly-6x His tag. In embodiment 32 provided herein is the composition of embodiment 30 wherein the purification tag comprises a gly-8x His tag. In embodiment 33 provided herein is the composition of any previous embodiment wherein the Type V CRISPR nuclease polypeptide comprises a cleavage site. In embodiment 34 provided herein is the composition of embodiment 33 wherein the cleavage site is at or near the N-terminus of the nuclease polypeptide. In embodiment 35 provided herein is the composition of embodiment 33 or embodiment 34 wherein the cleavage site comprises a Tobacco Etch Virus (TEV) cleavage site.

In embodiment 36 provided herein is the composition of embodiment 35 wherein the cleavage site comprises the sequence of SEQ ID NO: 108. In embodiment 37 provided herein is the composition of embodiment 36 comprising 5 NLSs at or near the N-terminus of the polypeptide, a purification tag, and the cleavage site, wherein the cleavage site is after the purification tag. In embodiment 38 provided herein is the composition of embodiment 37 comprising a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 8%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 111 or 112. In embodiment 39 provided herein is the composition of embodiment 37 comprising a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 8%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 112. In embodiment 40 provided herein is the composition of any previous embodiment further comprising a guide nucleic acid (gNA), e.g., gRNA, comprising a spacer sequence that targets a target nucleotide sequence within a polynucleotide, or a polynuclotide coding for the gNA, e.g., gRNA, wherein the gNA, e.g., gRNA is compatible with the Type V CRISPR nuclease. In embodiment 41 provided herein is the composition of embodiment 40 wherein the target nucleotide is within 50 nucleotides of a protospacer adjacent motif (PAM) sequence specific for the Type V CRISPR nuclease. In embodiment 42 provided herein is the composition of embodiment 41 wherein the PAM comprises a sequence of YTTN, wherein Y is T or C and N is A, T, G, or C. In embodiment 43 provided herein is the composition of embodiment 42 wherein the PAM comprises a sequence of YTTV or TTTV, wherein V is A, G, or C. In embodiment 44 provided herein is the composition of embodiment 40 wherein the gNA is a gRNA. In embodiment 45 provided herein is the composition of embodiment 44 wherein the gRNA is a dual gRNA. In embodiment 46 provided herein is the composition of embodiment 44 or embodiment 45 wherein the composition comprises the gRNA and the gRNA comprises one or more chemical modifications. In embodiment 47 provided herein is the composition of embodiment 46 wherein the chemical modification comprises a 2’-0-alkyl, a 2'-0-methyl, a phosphorothioate, a phosphonoacetate, a thiophosphonoacetate, a 2'-0-methyl-3'-phosphorothioate, a 2'-0-methy 1-3 '-phosphonoacetate, a 2'-0-methyl-3'-thiophosphonoacetate, a 2'-deoxy-3 '-phosphonoacetate, a 2'-deoxy-3'- thiophosphonoacetate, a suitable alternative, or a combination thereof. In embodiment 48 provided herein is the composition of any one of embodiments 44 through 47 wherein a ratio of guanine: uracil in the gRNA is at least 51:49, 52:48, 53:47, 54:46, 55:45, 56:44, 57:43, 58:42, 59:42, or 60:40, preferably at least 53:47, more preferably at least 54:46, even more preferably at least 55:45. In embodiment 49 provided herein is the composition of any one of embodiments 40 through 48 wherein the molar ratio of gNA, e.g., gRNA to Type V CRISPR nuclease is at least 1.1: 1, 1.2:1, 1.3: 1, 1.4: 1, 1.5: 1, 1.6: 1, 1.7: 1, 1.8: 1, 2: 1, 2.2: 1, 2.5: 1, or 3: 1 and/or not more than 1.2: 1, 1.3:1, 1.4: 1, 1.5: 1, 1.6: 1, 1.7: 1, 1.8: 1, 2: 1, 2.2: 1, 2.5: 1, 3: 1, or 4: 1, preferably 1.1: 1 to 2.5: 1, more preferably 1.2:1 to 2: 1„ even more preferably 1.2: 1 to 1.7: 1. In embodiment 50 provided herein is the composition of any one of embodiments 40 through 49 wherein the molar amount of gNA, e.g., gRNA, is at least 10, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 170, 190 or 200 pmol and/or not more than 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 170, 190 , 200, 250, or 300 pmol, preferably 25-200 pmol, more preferably 50-100 pmol, even more preferably 65 to 85 pmol. In embodiment 51 provided herein is the composition of any one of embodiments 40 through 50 further comprising a donor template. In embodiment 52 provided herein is the composition of embodiment 51 wherein the donor template comprises homology arms. In embodiment 53 provided herein is the composition of embodiment 51 or embodiment 52 wherein the donor template is present in an amount of at least 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2,

1.3, 1.4, 1.5, 1.7, 2, 2.5, 3, 4, or 5 pg pL-l and/or not more than 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.7, 2, 2.5, 3, 4, 5, 7, or 10 pg pL-l, preferably 0.3 to 2 pg pL-l, more preferably 0.5 to 1.5 pg pL-l, even more preferably 0.8 to 1.2 pg pL-l. In embodiment 54 provided herein is the composition of any one of embodiments 40 through 53 further comprising an anionic polymer. In embodiment 55 provided herein is the composition of embodiment 54 wherein the anionic polymer comprises polyglutamic acid (PGA). In embodiment 56 provided herein is the composition of embodiment 54 or embodiment 55 wherein the anionic polymer is present at a concentration of at least 20, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 170, 200, 250, 300, 400, or 500 pg pL-l and/or not more than 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 170, 200, 250, 300, 400, 500, 700, or 1000 pg pL-l, preferably 20 to 200 pg pL-l, more preferably 50 to 150 pg pL-l, even more preferably 80 to 120 pg pL-l..

[0272] In embodiment 57 provided herein is a cell containing the composition of any previous embodiment. In embodiment 58 provided herein is the cell of embodiment 56 wherein the cell is a human cell. In embodiment 59 provided herein is the cell of embodiment 58 wherein the cell is an immune cell or a stem cell. In embodiment 60 provided herein is the cell of embodiment 59 wherein the cell is an immune cell. In embodiment 61 provided herein is the cell of embodiment 60 wherein the cell is a T cell. In embodiment 62 provided herein is the cell of embodiment 59 wherein the cell is a stem cell. In embodiment 63 provided herein is the cell of embodiment 62 wherein the cell is an induced pluripotent stem cell (iPSC).

[0273] In embodiment 64 provided herein is a method comprising inserting a composition of any one of embodiments 1 through 56 into a cell. In embodiment 65 provided herein is the method of embodiment 64 wherein inserting the composition into the cell comprises electroporation.

[0274] In embodiment 66 provided herein is a method for modifying a target polynucleotide comprising (i) contacting the composition of any one of embodiments 40 through 56 and (ii) allowing the nuclease and the guide nucleic acid to modify a targeted genomic region. In embodiment 67 provided herein is the method of embodiment 66 wherein the composition is a composition of any one of embodiments 51 through 56. In embodiment 68 provided herein is the method of embodiment 66 or embodiment 67 wherein the target polynucleotide is a genome or a portion of a genome within a cell. In embodiment 69 provided herein is the method of embodiment 68 wherein the cell is a human cell. In embodiment 70 provided herein is the method of embodiment 69 wherein the cell is an immune cell or a stem cell. In embodiment 71 provided herein is the method of embodiment 70 wherein the cell is an immune cell. In embodiment 72 provided herein is the method of embodiment 71 wherein the cell is a T cell. In embodiment 73 provided herein is the method of embodiment 70 wherein the cell is a stem cell. In embodiment 74 provided herein is the method of embodiment 73 wherein the stem cell is an iPSC In embodiment 75 provided herein is the method of any one of embodiments 67 through 74 wherein the donor template comprises a mutation in a PAM within 50 nucleotides of the target nucleotide sequence in the target polynucleotide. In embodiment 76 provided herein is the method of any one of embodiments 68 through 74 wherein the composition is a composition of embodiment 67 and the donor template comprises a polynucleotide coding for a polypeptide to be expressed by the cell. In embodiment 77 provided herein is the method of embodiment 76 wherein the polypeptide to be expressed by the cell comprises a chimeric antigen receptor (CAR) or a portion thereof. In embodiment 78 provided herein is the method of embodiment 77 wherein the cell is a human T cell or a human iPSC. In embodiment 79 provided herein is the method of embodiment 77 wherein the cell is a human T cell. In embodiment 80 provided herein is the method of embodiment 77 wherein the cell is a human iPSC.

[0275] In embodiment 81 provided herein is a composition comprising a first polynucleotide coding for a polypeptide comprising a nucleic acid-guided nuclease comprising a CRISPR Type V nuclease polypeptide, wherein the polynucleotide has less than 75% sequence identity to SEQ ID NO: 22. In embodiment 82 provided herein is the composition of embodiment 81 wherein the nuclease polypeptide comprises at least 1, 2, 3, 4, or 5 NLSs, wherein each of the NLSs is at or near the N-terminus or the C-terminus of the nuclease polypeptide. In embodiment 83 provided herein is the composition of embodiment 82 wherein one or more of the NLSs comprises an NLS of the SV40 virus large T-antigen, an NLS from nucleoplasmin, e.g. a nucleoplasmin bipartite NLS, a c-myc NLS; a hRNPAl M9 NLS; an IBB domain of importin-alpha NLS; a myoma T protein NLS; a sequence from human p53 NLS; a sequence of mouse c-abl IV NLS; a sequence of influenza virus NS 1 NLS; a sequence of Hepatitis virus delta antigen NLS; a sequence of mouse Mxl protein NLS; a sequence of human poly(ADP-ribose) polymerase NLS; a sequence of steroid hormone receptors (human) glucocorticoid NLS; and/or a sequence of EGL-13 NLS.

In embodiment 84 provided herein is the composition of embodiment 83 wherein one or more of the NLSs comprises an NLS of the SV40 virus large T-antigen. In embodiment 85 provided herein is the composition of embodiment 84 wherein the NLS or NLSs comprises the sequence of SEQ ID NO: 5. In embodiment 86 provided herein is the composition of any one of embodiments 83 through 85 wherein one or more of the NLSs comprises an NLS from nucleoplasmin. In embodiment 87 provided herein is the composition of embodiment 86 wherein the nucleoplasmin NLS comprises the sequence of SEQ ID NO: 6. In embodiment 88 provided herein is the composition of any one of embodiments 83 through 87 wherein one or more of the NLSs comprises a c-myc NLS. In embodiment 89 provided herein is the composition of embodiment 88 wherein the c-myc NLS comprises the sequence of SEQ ID NO: 7, SEQ ID NO: 8, or SEQ ID NO: 21. In embodiment 90 provided herein is the composition of embodiment 88 wherein the c-myc NLS comprises the sequence SEQ ID NO: 21. In embodiment 91 provided herein is the composition of any one of embodiments 83 through 90 wherein one or more of the NLSs comprises a sequence of EGL-13 NLS. In embodiment 92 provided herein is the composition of embodiment 91 wherein the EGL-13 NLS comprises the sequence of SEQ ID NO: 107. In embodiment 93 provided herein is the composition of any one of embodiments 82 through 92 wherein the NLS or NLSs is at or near the N-terminus of the polypeptide. In embodiment 94 provided herein is the composition of any one of embodiments 81 through 93 wherein the first polynucleotide comprises a polynucleotide coding for a purification tag. In embodiment 95 provided herein is the composition of embodiment 94 wherein the purification tag is at or near the N-terminus of the nuclease polypeptide. In embodiment 96 provided herein is the composition of embodiment 94 or 95 wherein the purification tag comprises a poly -his tag, such as a Gly-6x His tag or Gly-8x His tag; short epitope tags, e.g., FLAG, hemagglutinin (HA), c-myc, T7, Glu-Glu; maltose binding protein (mbp); N-terminal glutathione S-transferase (GST); or calmodulin binding peptide (CBP). In embodiment 97 provided herein is the composition of embodiment 96 wherein the purification tag comprises a poly -his tag. In embodiment 98 provided herein is the composition of embodiment 97 wherein the purification tag comprises a gly-6x His tag. In embodiment 99 provided herein is the composition of embodiment 97 wherein the purification tag comprises a gly-8x His tag. In embodiment 100 provided herein is the composition of any one of embodiments 81 through 99 wherein the Type V CRISPR nuclease polypeptide comprises a cleavage site. In embodiment 101 provided herein is the composition of embodiment 100 wherein the cleavage site is at or near the N-terminus of the nuclease polypeptide. In embodiment 102 provided herein is the composition of embodiment 100 or 101 wherein the cleavage site comprises a Tobacco Etch Virus (TEV) cleavage site. In embodiment 103 provided herein is the composition of embodiment 102 wherein the cleavage site comprises the sequence of SEQ ID NO: 108. In embodiment 104 provided herein is the composition of embodiment 103 comprising 5 NLSs at or near the N-terminus of the polypeptide, a purification tag, and the cleavage site, wherein the cleavage site is after the purification tag. In embodiment 105 provided herein is the composition of any one of embodiments 81 through 104 wherein the polynucleotide codes for a polypeptide comprising a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, identical, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to any one of SEQ ID NOs: 109-112 In embodiment 106 provided herein is the composition of any one of embodiments 81 through 105 wherein the polynucleotide codes for a polypeptide comprising a sequence at least 60, 70, 80, 85, 90, 95, 98, 99%, or 100%, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical identical to SEQ ID NO: 112. In embodiment 107 provided herein is the composition of any one of embodiments 81 through 105 wherein the first polynucleotide comprises a sequence at least 50, 60, 70, 80, 90, 95, 97, or 99% identical, or 100% identical , preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, still more preferably at least 98% identical to SEQ ID NO: 113. In embodiment 108 provided herein is the composition of any one of embodiments 81 through 107 further comprising a second polynucleotide coding for a gNA or portion thereof, wherein the gNA, e.g., gRNA, comprises a spacer sequence that targets a target nucleotide sequence within a polynucleotide, or a polynuclotide coding for the gNA, e.g., gRNA, wherein the gNA, e.g., gRNA is compatible with the Type V CRISPR nuclease. In embodiment 109 provided herein is the composition of embodiment 108 wherein the first and second polynucleotides are the same. In embodiment 110 provided herein is the composition of any one of embodiments 81 through 109 further comprising third polynucleotide that comprises a donor template.

[0276] In embodiment 111 provided herein is a vector comprising the polynucleotide or polynucleotides of any one of embodiments 81 through 110.

[0277] In embodiment 112 provided herein is a cell comprising a composition of any one of embodiments 81 through 110. In embodiment 113 provided herein is the composition of embodiment 112 wherein the cell is a human cell. In embodiment 114 provided herein is the composition of embodiment 113 wherein the cell is an immune cell or a stem cell. In embodiment 115 provided herein is the composition of embodiment 113 wherein the cell is an immune cell. In embodiment 116 provided herein is the composition of embodiment 115 wherein the cell is T cell. In embodiment 117 provided herein is the composition of embodiment 113 wherein the cell is a stem cell. In embodiment 118 provided herein is the composition of embodiment 117 wherein the cell is an iPSC. [0278] In embodiment 119 provided herein is a method comprising inserting the composition of any one of embodiments 81 through 111 into a cell. In embodiment 120 provided herein is the method of embodiment 119 wherein inserting the composition into the cell comprises electroporation. [0279] In embodiment 121 provided herein is a method comprising (i) inserting a composition of any one of embodiments 81 through 107 into a cell and (ii) inserting a gNA, e.g. a gRNA, compatible with the Type V CRISPR nuclease coded for by the composition, into the cell. In embodiment 122 provided herein is the method of embodiment 121 wherein steps (i) and (ii) comprise electroporation. [0280] While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby.