Title:
MODIFIED OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2007/094218
Kind Code:
A1
Abstract:
A modified oligonucleotide comprising an oligonucleotide containing at its
3’end a modified nucleoside as a structural component, wherein the modified
nucleoside is one having a carboxylic acid or steroid skeleton containing compound
linked via a linker to the 3’end of nucleoside. The modified oligonucleotide
can be produced by solid-phase synthesis using any of the unit compounds for solid-phase
synthesis represented by the formula (XIA) or the unit compounds for solid-phase
synthesis represented by the formula (XIS) as a starting material. (XIA) (XIS)
wherein R1, R2, n, m, RA and RS are as
defined in the description.
Inventors:
KITADE YUKIO
UENO YOSHIHITO
WATAYA YUSUKE
UENO YOSHIHITO
WATAYA YUSUKE
Application Number:
PCT/JP2007/052129
Publication Date:
August 23, 2007
Filing Date:
February 07, 2007
Export Citation:
Assignee:
UNIV GIFU (JP)
UNIV OKAYAMA NAT UNIV CORP (JP)
KITADE YUKIO
UENO YOSHIHITO
WATAYA YUSUKE
UNIV OKAYAMA NAT UNIV CORP (JP)
KITADE YUKIO
UENO YOSHIHITO
WATAYA YUSUKE
International Classes:
C07H21/04; C07J9/00; C12N15/09
Domestic Patent References:
| WO1995023162A1 | 1995-08-31 |
Foreign References:
| JPH06500556A | 1994-01-20 | |||
| JPS62277395A | 1987-12-02 | |||
| JPS61238797A | 1986-10-24 | |||
| JPH0995495A | 1997-04-08 |
Other References:
SOUTSCHEK J. ET AL.: "Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs", NATURE, vol. 432, 2004, pages 173 - 178, XP002336040
KAWASAKI A.M. ET AL.: "Uniformly Modified 2'-Deoxy-20-fluoro Phosphorothioate Oligonucleotides as Nuclease-Resistant Antisense Compounds with High Affinity and Specificity for RNA Targets", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 7, 1993, pages 831 - 841, XP000562792
KAWASAKI A.M. ET AL.: "Uniformly Modified 2'-Deoxy-20-fluoro Phosphorothioate Oligonucleotides as Nuclease-Resistant Antisense Compounds with High Affinity and Specificity for RNA Targets", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 7, 1993, pages 831 - 841, XP000562792
Attorney, Agent or Firm:
IKEUCHI SATO & PARTNER PATENT ATTORNEYS (OAP TOWER 8-30, Tenmabashi 1-chome, Kita-k, Osaka-shi Osaka 26, JP)
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