Title:
MODIFIED PEPTIDE NUCLEIC ACID COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2021/202621
Kind Code:
A3
Abstract:
The present disclosure relates to compounds useful for the detection or modulation of target nucleic acids, including DNA and RNA. The present disclosure further relates to methods for treatment of trinucleotide repeat disorders, which can include administration of oligonucleotide analogues that can bind pathogenic nucleotide repeats in DNA or RNA.
Inventors:
LY DANITH H (US)
THADKE SHIVAJI A (US)
BATWAL RAMESH U (US)
DI CARO VALENTINA (US)
STEPHAN DIETRICH A (US)
SOOTER LETHA J (US)
BACKENROTH SAMUEL I (US)
THADKE SHIVAJI A (US)
BATWAL RAMESH U (US)
DI CARO VALENTINA (US)
STEPHAN DIETRICH A (US)
SOOTER LETHA J (US)
BACKENROTH SAMUEL I (US)
Application Number:
PCT/US2021/025019
Publication Date:
November 11, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
NEUBASE THERAPEUTICS INC (US)
International Classes:
C12Q1/6848; C12Q1/6853
Other References:
MELONI ET AL.: "Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action", FRONTIERS IN NEUROLOGY, vol. 11, no. 108, 25 February 2020 (2020-02-25), pages 108, XP055873065
RAY ET AL.: "Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future", THE FASEB JOURNA L, vol. 14, 2000, pages 1041 - 1060, XP001162782
CHOWDHURY SAIFUL M. ET AL.: "Solid-phase N-terminal peptide enrichment study by optimizing trypsin proteolysis on homoarginine modified proteins by mass spectrometry", RAPID COMMUN MASS SPECTROM, vol. 28, no. 6, 30 March 2014 (2014-03-30), pages 635 - 644, XP055873067
RAY ET AL.: "Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future", THE FASEB JOURNA L, vol. 14, 2000, pages 1041 - 1060, XP001162782
CHOWDHURY SAIFUL M. ET AL.: "Solid-phase N-terminal peptide enrichment study by optimizing trypsin proteolysis on homoarginine modified proteins by mass spectrometry", RAPID COMMUN MASS SPECTROM, vol. 28, no. 6, 30 March 2014 (2014-03-30), pages 635 - 644, XP055873067
Attorney, Agent or Firm:
WANG, Jing (US)
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