MODIFIED POLYPEPTIDES WITH THERAPEUTIC ACTIVITY AND METHODS OF USE

Title:

MODIFIED POLYPEPTIDES WITH THERAPEUTIC ACTIVITY AND METHODS OF USE

Document Type and Number:

WIPO Patent Application WO2005042699

Kind Code:

A3

Abstract:

Polypeptides modified by fatty acid conjugation and methods of using such modified poilypeptides in treating bacterial infections, including the treatment of antibiotic resistant bacterial infections, are disclosed.

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Inventors:

MAYO KEVIN H (US)

Application Number:

PCT/US2004/034204

Publication Date:

July 13, 2006

Filing Date:

October 15, 2004

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Assignee:

UNIV MINNESOTA (US)
MAYO KEVIN H (US)

International Classes:

A61K38/10; A61K38/00; A61K38/17; C07H21/04; C07K2/00; C07K7/08; C07K14/47; C12N

Domestic Patent References:

WO2001053335A2

2001-07-26

Foreign References:

US20020146406A1

2002-10-10

Other References:

MAYO K.H.: "Structure-function relationships in novel peptide doceames with broad-specturn bactericidal and endotoxin-neutralizing activities", BIOCHEM. J., vol. 349, 2000, pages 717 - 728, XP002172349

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