Title:
MODIFIED RECOMBINANT HUMAN ENDOSTATIN AND ITS APPLICATION
Document Type and Number:
WIPO Patent Application WO/2009/033406
Kind Code:
A1
Abstract:
Provided is a kind of modified recombinant human endostatin that has the structure of CH3O-(CH2CH2O)m-CH2CH2CH2-NαH-Endostar, wherein the average molecular weight of CH3O-(CH2CH2O)m-CH2CH2CH2 is 20-40kD. The modified recombinant human endostatin enhances the stability in vivo, improves blood drug concentration, prolongs half-life, markedly increases the activity of inhibiting the endothelial cells proliferation, thus reduces drug dosage and decreases administration frequency. Its application for preparing anti-tumor pharmaceutical compositions is also provided.
Inventors:
YAO WENBING (CN)
TIAN HONG (CN)
XU XIANGYANG (CN)
LI HAIRUI (CN)
TONG YUE (CN)
GAO XIANGDONG (CN)
TIAN HONG (CN)
XU XIANGYANG (CN)
LI HAIRUI (CN)
TONG YUE (CN)
GAO XIANGDONG (CN)
Application Number:
PCT/CN2008/072261
Publication Date:
March 19, 2009
Filing Date:
September 04, 2008
Export Citation:
Assignee:
JIANGSU SIMCERE PHARMACEUTICAL (CN)
UNIV CHINA PHARMA (CN)
SHANDONG XIANSHENG MAIDEJIN BI (CN)
YAO WENBING (CN)
TIAN HONG (CN)
XU XIANGYANG (CN)
LI HAIRUI (CN)
TONG YUE (CN)
GAO XIANGDONG (CN)
UNIV CHINA PHARMA (CN)
SHANDONG XIANSHENG MAIDEJIN BI (CN)
YAO WENBING (CN)
TIAN HONG (CN)
XU XIANGYANG (CN)
LI HAIRUI (CN)
TONG YUE (CN)
GAO XIANGDONG (CN)
International Classes:
C07K17/08; A61K38/18; A61K47/48; A61P35/00; C07K1/107; C07K14/475
Foreign References:
| CN1891717A | 2007-01-10 | |||
| CN101002946A | 2007-07-25 | |||
| CN1324818A | 2001-12-05 | |||
| CN1876186A | 2006-12-13 | |||
| CN101224297A | 2008-07-23 | |||
| EP1985302A1 | 2008-10-29 | |||
| CN1891717A | 2007-01-10 | |||
| CN101002946A | 2007-07-25 |
Other References:
WU J ET AL: "PEG Modification of Protein Drug", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 26, no. 3, March 2002 (2002-03-01), pages 146 - 151
Y. LING ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 361, 2007, pages 79 - 84
O. KINSTLER ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 477 - 485
YONGJUN NIE ET AL., BIOCONJUGATE CHEM., vol. 17, 2006, pages 995 - 999
Y. LING ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 361, 2007, pages 79 - 84
O. KINSTLER ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 477 - 485
YONGJUN NIE ET AL., BIOCONJUGATE CHEM., vol. 17, 2006, pages 995 - 999
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENCY CO., LTD. (Jiangsu Jixie BuildingNo.49, North Zhongshan Road, Gulo, Nanjing Jiangsu 8, CN)
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