Title:
MODIFIED SIS MEMBRANE FOR TISSUE REPAIR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045001
Kind Code:
A1
Abstract:
A modified SIS membrane for tissue repair, a preparation method therefor and a use thereof. Specifically provided is a composition comprising a fusion polypeptide-modified SIS film and an extracellular vesicle, as well as a preparation method for and a use of the composition. It is proved that the fusion polypeptide-mediated SIS film and the composition containing the SIS film and the extracellular vesicle have excellent biological functions, and provide a broad prospect for treating bone defects or facilitating tissue healing or bone regeneration.
Inventors:
ZHAO BO (CN)
WANG HUASHENG (CN)
WEI PENGFEI (CN)
JING WEI (CN)
LIU ZIHAO (CN)
WANG HUASHENG (CN)
WEI PENGFEI (CN)
JING WEI (CN)
LIU ZIHAO (CN)
Application Number:
PCT/CN2021/124991
Publication Date:
March 30, 2023
Filing Date:
October 20, 2021
Export Citation:
Assignee:
BEIJING BIOSIS HEALING BIOLOGICAL TECH CO LTD (CN)
International Classes:
A61L27/36; A61K9/133; A61P19/00; C07K19/00
Foreign References:
| CN105111283A | 2015-12-02 | |||
| CN107029224A | 2017-08-11 | |||
| CN109152737A | 2019-01-04 | |||
| US20190328792A1 | 2019-10-31 |
Other References:
ZHANG LEI, MA SHIQING, WEI PENGFEI, ZHAO YIFAN, MU YUZHU, WU JINZHE, JING WEI, ZHAO BO, DENG JIAYIN, LIU ZIHAO: "Small Intestinal Submucosa Membrane Modified by Fusion Peptide‐Mediated Extracellular Vesicles to Promote Tissue Regeneration", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 10, no. 22, 1 November 2021 (2021-11-01), DE , pages 2101298, XP093054879, ISSN: 2192-2640, DOI: 10.1002/adhm.202101298
MA SHIQING, WU JINZHE, HU HAN, MU YUZHU, ZHANG LEI, ZHAO YIFAN, BIAN XIAOWEI, JING WEI, WEI PENGFEI, ZHAO BO, DENG JIAYIN, LIU ZIH: "Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration", MATERIALS TODAY BIO, vol. 13, 1 January 2022 (2022-01-01), pages 100195, XP093054877, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2021.100195
MU YUZHU, SHIQING MA,PENGFEI WEI,YONGLAN WANG,WEI JING,YIFAN ZHAO,LEI ZHANG,JINZHE WU,BO ZHAO,JIAYIN DENG,ZIHAO LIU: "Multifunctional Modification of SIS Membrane with Chimeric Peptides to Promote Its Antibacterial, Osteogenic, and Healing-Promoting Abilities for Applying to GBR", ADV. FUNCT. MATER., vol. 31, no. 31, 28 May 2021 (2021-05-28), pages e2101452, XP055982062, DOI: 10.1002/adfm.202101452
LEE CHANGSUN, SHIM SEHWAN, JANG HYOSUN, MYUNG HYUNWOOK, LEE JANET, BAE CHANG-HWAN, MYUNG JAE KYUNG, KIM MIN-JUNG, LEE SEUNG BUM, J: "Human umbilical cord blood–derived mesenchymal stromal cells and small intestinal submucosa hydrogel composite promotes combined radiation-wound healing of mice", CYTOTHERAPY, ISIS MEDICAL MEDIA, OXFORD,, GB, vol. 19, no. 9, 1 September 2017 (2017-09-01), GB , pages 1048 - 1059, XP093049500, ISSN: 1465-3249, DOI: 10.1016/j.jcyt.2017.06.007
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
MA SHIQING, WU JINZHE, HU HAN, MU YUZHU, ZHANG LEI, ZHAO YIFAN, BIAN XIAOWEI, JING WEI, WEI PENGFEI, ZHAO BO, DENG JIAYIN, LIU ZIH: "Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration", MATERIALS TODAY BIO, vol. 13, 1 January 2022 (2022-01-01), pages 100195, XP093054877, ISSN: 2590-0064, DOI: 10.1016/j.mtbio.2021.100195
MU YUZHU, SHIQING MA,PENGFEI WEI,YONGLAN WANG,WEI JING,YIFAN ZHAO,LEI ZHANG,JINZHE WU,BO ZHAO,JIAYIN DENG,ZIHAO LIU: "Multifunctional Modification of SIS Membrane with Chimeric Peptides to Promote Its Antibacterial, Osteogenic, and Healing-Promoting Abilities for Applying to GBR", ADV. FUNCT. MATER., vol. 31, no. 31, 28 May 2021 (2021-05-28), pages e2101452, XP055982062, DOI: 10.1002/adfm.202101452
LEE CHANGSUN, SHIM SEHWAN, JANG HYOSUN, MYUNG HYUNWOOK, LEE JANET, BAE CHANG-HWAN, MYUNG JAE KYUNG, KIM MIN-JUNG, LEE SEUNG BUM, J: "Human umbilical cord blood–derived mesenchymal stromal cells and small intestinal submucosa hydrogel composite promotes combined radiation-wound healing of mice", CYTOTHERAPY, ISIS MEDICAL MEDIA, OXFORD,, GB, vol. 19, no. 9, 1 September 2017 (2017-09-01), GB , pages 1048 - 1059, XP093049500, ISSN: 1465-3249, DOI: 10.1016/j.jcyt.2017.06.007
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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