MODIFIED STEM CELL COMPOSITIONS AND METHODS FOR USE

Title:

MODIFIED STEM CELL COMPOSITIONS AND METHODS FOR USE

Document Type and Number:

WIPO Patent Application WO/2024/036214

Kind Code:

A3

Abstract:

Disclosed herein is a modified cell comprising one, two, or more exogenous or introduced nucleic acid sequences, each encoding a CD47, a modified CD117, and/or a CXCR4 polypeptide, including functional fragments or variants thereof. In some embodiments, the CD47, modified CD117, and/or CXCR4 polypeptides are transiently expressed in the cell. In some embodiments, the nucleic acid sequence comprises, optionally from 5' to 3': a 5' UTR, a 5' terminal cap sequence, a sequence encoding the CXCR4, CD47, and/or a modified CD117 protein, a stop codon, and a 3' UTR.

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Inventors:

PANG WENDY (US)
TIWARI RAJIV (US)
KWON HYE-SOOK (US)
SHIZURU JUDITH (US)
SIKORSKI ROBERT (US)
D’ESPAUX LEOPOLD (US)
LEE SONG EUN (US)

Application Number:

PCT/US2023/071937

Publication Date:

April 18, 2024

Filing Date:

August 09, 2023

Export Citation:

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Assignee:

JASPER THERAPEUTICS INC (US)

International Classes:

A61K35/12; A61K35/545; C12N5/0789

Attorney, Agent or Firm:

LAHERTY, Carol et al. (US)

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