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Patent Searching and Data


Title:
MODIFIED VIRUS VECTORS AND METHODS OF MAKING AND USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2010/093784
Kind Code:
A3
Abstract:
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors comprising the modified AAV capsid protein. In particular embodiments, the modification comprises a substitution of one or more amino acids at amino acid positions 585 to 590 (inclusive) of the native AAV2 capsid protein sequence or the corresponding positions of other AAV capsid proteins. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.

Inventors:
SAMULSKI RICHARD JUDE (US)
ASOKAN ARAVIND (US)
Application Number:
PCT/US2010/023885
Publication Date:
December 16, 2010
Filing Date:
February 11, 2010
Export Citation:
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Assignee:
UNIV NORTH CAROLINA (US)
SAMULSKI RICHARD JUDE (US)
ASOKAN ARAVIND (US)
International Classes:
C07K14/075; A61P3/00; A61P9/00; A61P21/00; C12N15/861
Domestic Patent References:
WO2004111248A22004-12-23
WO2005005610A22005-01-20
Foreign References:
US20050287122A12005-12-29
Other References:
OPIE, S. R. ET AL.: "Identification of amino acid residues in the capsid prot eins of adeno-associated virus type 2 that contribute to heparan sulfate pro teoglycan binding", JOURNAL OF VIROLOGY., vol. 77, no. 12, June 2003 (2003-06-01), pages 6995 - 7006, XP008152104
WU, P. ET AL.: "Mutational analysis of the adeno-associated virus type 2 (AAV 2) capsid gene and construction of AAV2 vectors with altered tropism.", JOURNAL OF VIROLOGY., vol. 74, no. 18, September 2000 (2000-09-01), pages 8635 - 8647, XP001028219
See also references of EP 2396343A4
Attorney, Agent or Firm:
MYERS BIGEL SIBLEY & SAJOVEC, P.A. (Raleigh, North Carolina, US)
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