Title:
MODULAR MOLECULAR CLASPS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002079387
Kind Code:
A3
Abstract:
The present invention provides Modular Molecular Clasps and methods of using these Modular Molecular Clasps in a wide range of applications in the health care industry, e.g., in therapy, in clinical diagnostics, in in vivo imaging or in drug discovery. The Modular Molecular Clasps of the present invention also have industrial and environmental applications, e.g., in environmental diagnostics, industrial diagnostics, food safety, toxicology, catalysis of reactions or high-throughput screening; as well as applications in the agricultural industry and in basic research. Methods of designing the Modular Molecular Clasps, as well as arrays and biosensors comprising these Modular Molecular Clasps are also provided.
Inventors:
RIZZUTO CARLO DANTE
AFEYAN NOUBAR BOGHOS
LEE FRANK DON
CHURCH GEORGE MCDONALD
GUPTA RUCHIRA DAS
SCHWARTZ JOHN JACOB
ZHANG BIN
LUGOVSKOY ALEXEY ALEXANDROVICH
AFEYAN NOUBAR BOGHOS
LEE FRANK DON
CHURCH GEORGE MCDONALD
GUPTA RUCHIRA DAS
SCHWARTZ JOHN JACOB
ZHANG BIN
LUGOVSKOY ALEXEY ALEXANDROVICH
Application Number:
PCT/US2002/010171
Publication Date:
February 20, 2003
Filing Date:
March 28, 2002
Export Citation:
Assignee:
ENGENEOS INC (US)
International Classes:
C07K19/00; C12N15/62; G01N33/542; A61K38/00; (IPC1-7): C07K19/00; C07K14/00; C07K16/00
Foreign References:
| US5998204A | 1999-12-07 |
Other References:
WENNER ET AL.: "Genetically designed biosensing systems for high-throughput screening of pharmaceuticals, clinical diagnostics and environmental monitoring", PROCEEDINGS OF THE SPIE-THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, vol. 4252, 2001, (ADVANCES IN FLUORESCENCE SENSING TECHNOLOGY V), pages 59 - 70, XP002957858
SALINS ET AL.: "A novel reagentless sensing system for measuring glucose based on the galactose/glucose-binding protein", ANALYTICAL BIOCHEMISTRY, vol. 294, no. 1, 2001, pages 19 - 26, XP002957859
SALINS ET AL.: "Fluorescent biosensing systems based on analyte-induced conformational changes of genetically engineered periplasmic binding proteins", ACS SYMPOSIUM SERIES, vol. 762, 2000, (CHEMICAL AND BIOLOGICAL SENSORS FOR ENVIRONMENTAL MONITORING), pages 87 - 101, XP002957860
SALINS ET AL.: "A novel reagentless sensing system for measuring glucose based on the galactose/glucose-binding protein", ANALYTICAL BIOCHEMISTRY, vol. 294, no. 1, 2001, pages 19 - 26, XP002957859
SALINS ET AL.: "Fluorescent biosensing systems based on analyte-induced conformational changes of genetically engineered periplasmic binding proteins", ACS SYMPOSIUM SERIES, vol. 762, 2000, (CHEMICAL AND BIOLOGICAL SENSORS FOR ENVIRONMENTAL MONITORING), pages 87 - 101, XP002957860
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