Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
MODULATION OF ANXIETY THROUGH BLOCKADE OF ANANDAMIDE HYDROLYSIS
Document Type and Number:
WIPO Patent Application WO2004033422
Kind Code:
A3
Abstract:
Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R1 and R2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R1 and R2 is absent, and that, if Z is N, optionally R1 and R2 may optionally be taken together to form a substituted or unsubstituted N-heterocycle or substituted or unsubstituted heteroaryl with the N atom to which they are each attached. Pharmaceutical compositions comprising the compounds of Formula (I) and methods of using them to inhibit FAAH and/or treat appetite disorders, glaucoma, pain, insomnia, and neurological and psychological disorders including anxiety disorders, epilepsy, and depression are provided.

Inventors:
PIOMELLI DANIELE (US)
DURANTI ANDREA (IT)
TONTINI ANDREA (IT)
MOR MARCO (IT)
TARZIA GEORGIO (IT)
Application Number:
US0331844W
Publication Date:
July 29, 2004
Filing Date:
October 07, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV CALIFORNIA (US)
PIOMELLI DANIELE (US)
DURANTI ANDREA (IT)
TONTINI ANDREA (IT)
MOR MARCO (IT)
TARZIA GEORGIO (IT)
International Classes:
C07C271/00; C07C271/56; C07C275/54; C07C311/29; C07D403/04; C07D403/06; C07D403/12; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D409/06; C07D409/12; (IPC1-7): C07C271/00; A61K31/21
Foreign References:
JPH0892167A1996-04-09
Other References:
See also references of EP 1558591A4
Download PDF: