MODULATION OF HOTAIR AND ADIPOGENESIS

WIPO Patent Application WO/2015/153880

A3

Provided herein are compositions and methods for forming adipose tissue. One aspect provides a method including contacting adipose progenitor cells and an agent for modulating HOX antisense intergenic RNA ("HOTAIR"), an adipose-derived exosome, a miRNA associated with an adipose-derived exosome, or a demethylation agent. Such contact can induce or increase adipogenesis, formation of white adipose, formation brown adipose, or transition of white adipose to brown adipose.

WO/2011/131371	LIPID BINDING NUCLEIC ACIDS
JP6389124	Fusion protein containing the C-terminal domain of RET protein and its use as a diagnostic marker
JP2003510282	[Title of Invention] Immunostimulatory nucleic acid

MAO JEREMY J (US)
YANG GUODONG (US)

PCT/US2015/024079

December 10, 2015

April 02, 2015

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UNIV COLUMBIA (US)

A61K31/7088; A61K31/7105; C12N15/113

WO2012045093A1	2012-04-05
WO2009137613A2	2009-11-12
WO2014013029A1	2014-01-23

KLENGEL, T ET AL.: "Allele-Specific FKBP5 DNA Demethylation Mediates Gene -Childhood Trauma Interactions.", NAT NEUROSCI., vol. 16, no. 1, January 2013 (2013-01-01), pages 33 - 41, XP055241884
DIVOUX, A ET AL.: "Identification Of A Novel IncRNA In Gluteal Adipose Tissue And Evidence For Its Positive Effect On Preadipocyte Differentiation.", OBESITY (SILVER SPRING)., vol. 22, no. 8, 2 May 2014 (2014-05-02), pages 1781 - 1785, XP055241888

BOCK, Joel N. (P.O. Box 061080 Wacker Drive Station,,Willis Towe, Chicago Illinois, US)

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