Title:
MODULATION OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11 EXPRESSION
Document Type and Number:
WIPO Patent Application WO2004043391
Kind Code:
A3
Abstract:
Compounds, compositions and methods are provided for modulating the expression of mitogen-activated protein kinase kinase kinase 11. The compositions comprise oligonucleotides, targeted to nucleic acid encoding mitogen-activated protein kinase kinase kinase 11. Methods of using these compounds for modulation of mitogen-activated protein kinase kinase kinase 11 expression and for diagnosis and treatment of disease associated with expression of mitogenactivated protein kinase kinase kinase 11 are provided.
Inventors:
BENNETT C FRANK (US)
DEAN NICHOLAS M (US)
DOBIE KENNETH W (US)
DEAN NICHOLAS M (US)
DOBIE KENNETH W (US)
Application Number:
PCT/US2003/035845
Publication Date:
February 16, 2006
Filing Date:
November 12, 2003
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
BENNETT C FRANK (US)
DEAN NICHOLAS M (US)
DOBIE KENNETH W (US)
BENNETT C FRANK (US)
DEAN NICHOLAS M (US)
DOBIE KENNETH W (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Foreign References:
| US20020197658A1 | 2002-12-26 | |||
| US6811992B1 | 2004-11-02 |
Other References:
HARTKAMP J, TROPPMAIR J, RAPP UR.: "The JNK/SAPK Activator Mixed Lineage Kinase 3 (MLK3) Transforms NIH 3T3 Cells in a MEK-Dependent Fashion.", CANCER RESEARCH., vol. 59, no. 9, 1 May 1999 (1999-05-01), pages 2195 - 2202, XP002994710
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