Title:
MODULATION OF SGLT2 EXPRESSION
Document Type and Number:
WIPO Patent Application WO2005042552
Kind Code:
A3
Abstract:
Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
Inventors:
FREIER SUSAN M (US)
WANCEWICZ EDWARD (US)
MONIA BRETT P (US)
SIWKOWSKI ANDREW M (US)
WATTS LYNETTA (US)
LEEDOM THOMAS A (US)
WANCEWICZ EDWARD (US)
MONIA BRETT P (US)
SIWKOWSKI ANDREW M (US)
WATTS LYNETTA (US)
LEEDOM THOMAS A (US)
Application Number:
PCT/US2004/036620
Publication Date:
December 29, 2005
Filing Date:
November 03, 2004
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
FREIER SUSAN M (US)
WANCEWICZ EDWARD (US)
MONIA BRETT P (US)
SIWKOWSKI ANDREW M (US)
WATTS LYNETTA (US)
LEEDOM THOMAS A (US)
FREIER SUSAN M (US)
WANCEWICZ EDWARD (US)
MONIA BRETT P (US)
SIWKOWSKI ANDREW M (US)
WATTS LYNETTA (US)
LEEDOM THOMAS A (US)
International Classes:
A61K31/70; A61K48/00; C07H21/02; C07H21/04; C12N15/11; C12N15/113; C12Q1/68; C07H; (IPC1-7): C07H21/04
Foreign References:
| US5998148A | 1999-12-07 | |||
| US5240847A | 1993-08-31 | |||
| US6537751B1 | 2003-03-25 |
Other References:
YOU ET AL: "Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney.", J BIOL CHEM., vol. 270, December 1995 (1995-12-01), pages 29365 - 29371, XP002139557
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