Title:
MODULATOR OF INDOLEAMINE 2,3-DIOXYGENASE, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/144859
Kind Code:
A1
Abstract:
Provided is a modulator of indoleamine 2,3-dioxygenase, a preparation method and a use thereof. Specifically, it relates to a compound of the Formula (I) and Formula (II), an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, and a use in preparing the medicines for treating cancer, neurodegenerative disease, eye diseases, mental disorders, depression, anxiety disorders, Alzheimer's disease and/or autoimmune diseases. Wherein, the specific meanings of the R substituents in Formula (I) and Formula (II) are consistent with the description in the specification.
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Inventors:
QIN YINLIN (CN)
SU MEI (CN)
JI MIN (CN)
LIU HAIDONG (CN)
ZONG XI (CN)
WU XIANZHI (CN)
SU MEI (CN)
JI MIN (CN)
LIU HAIDONG (CN)
ZONG XI (CN)
WU XIANZHI (CN)
Application Number:
PCT/CN2019/072626
Publication Date:
August 01, 2019
Filing Date:
January 22, 2019
Export Citation:
Assignee:
NANJING CAREPHAR SHENGHUI PHARMACEUTICAL CO LTD (CN)
JIANGSU CAREPHAR PHARMACEUTICAL CO LTD (CN)
JIANGSU CAREPHAR PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D271/08; A61K31/41; A61K31/4245; A61K39/395; A61P1/00
Domestic Patent References:
| WO2017044983A1 | 2017-03-16 |
Foreign References:
| CN102164902A | 2011-08-24 |
Other References:
LV , YUJIAN ET AL.: "Prodrugs: Design and Clinical Application", JOURNAL OF INTERNATIONAL PHARMACEUTICAL RESEARCH, vol. 35, no. 5, 31 October 2008 (2008-10-31), pages 377 - 380, 387
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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