Title:
MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/124042
Kind Code:
A3
Abstract:
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Inventors:
WANG YING (US)
BREWER JASON T (US)
AKRITOPOULOU-ZANZE IRINI (US)
DJURIC STEVAN W (US)
POHLKI FRAUKE (DE)
BRAJE WILFRIED (DE)
RELO ANA-LUCIA (DE)
BREWER JASON T (US)
AKRITOPOULOU-ZANZE IRINI (US)
DJURIC STEVAN W (US)
POHLKI FRAUKE (DE)
BRAJE WILFRIED (DE)
RELO ANA-LUCIA (DE)
Application Number:
PCT/US2010/031974
Publication Date:
February 03, 2011
Filing Date:
April 22, 2010
Export Citation:
Assignee:
ABBOTT LAB (US)
ABBOTT GMBH & CO KG (DE)
WANG YING (US)
BREWER JASON T (US)
AKRITOPOULOU-ZANZE IRINI (US)
DJURIC STEVAN W (US)
POHLKI FRAUKE (DE)
BRAJE WILFRIED (DE)
RELO ANA-LUCIA (DE)
ABBOTT GMBH & CO KG (DE)
WANG YING (US)
BREWER JASON T (US)
AKRITOPOULOU-ZANZE IRINI (US)
DJURIC STEVAN W (US)
POHLKI FRAUKE (DE)
BRAJE WILFRIED (DE)
RELO ANA-LUCIA (DE)
International Classes:
C07D498/04; C07D471/04; C07D471/14; C07D487/04; C07D491/04; A61K31/4985; A61K31/551; A61K31/553; A61P25/00
Domestic Patent References:
| WO2009098236A1 | 2009-08-13 | |||
| WO2008007661A1 | 2008-01-17 | |||
| WO1988007997A1 | 1988-10-20 |
Foreign References:
| US20080188460A1 | 2008-08-07 | |||
| EP0463691A2 | 1992-01-02 | |||
| EP0206225A2 | 1986-12-30 |
Other References:
RUSSELL, MICHAEL G. N. ET AL: "Benz[f]isoquinoline analogs as high-affinity .sigma. ligands", JOURNAL OF MEDICINAL CHEMISTRY , 35(11), 2025-33 CODEN: JMCMAR; ISSN: 0022-2623, 1992, XP009139166
BHANDARI, K. ET AL: "Agents acting on the central nervous system. Part XXXIV. 1,2,3,4,4a,5,6,7-Octahydropyrazino[1,2-a]-1-benzazepines", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY , 25B(12), 1231-3 CODEN: IJSBDB; ISSN: 0376-4699, 1986, XP009139173
MUELLER, WERNER ET AL: "Seven-membered heterocyclics. Part 29. Synthesis of 1,2-annelated 1,4-benzodiazepines and 4,1-benzoxazepines", HELVETICA CHIMICA ACTA , 65(7), 2118-32 CODEN: HCACAV; ISSN: 0018-019X, 1982, XP009139171
SMITH, R. G. ET AL: "Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives", JOURNAL OF MEDICINAL CHEMISTRY , 23(8), 952-5 CODEN: JMCMAR; ISSN: 0022-2623, 1980, XP009139174
BHANDARI, K. ET AL: "Agents acting on the central nervous system. Part XXXIV. 1,2,3,4,4a,5,6,7-Octahydropyrazino[1,2-a]-1-benzazepines", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY , 25B(12), 1231-3 CODEN: IJSBDB; ISSN: 0376-4699, 1986, XP009139173
MUELLER, WERNER ET AL: "Seven-membered heterocyclics. Part 29. Synthesis of 1,2-annelated 1,4-benzodiazepines and 4,1-benzoxazepines", HELVETICA CHIMICA ACTA , 65(7), 2118-32 CODEN: HCACAV; ISSN: 0018-019X, 1982, XP009139171
SMITH, R. G. ET AL: "Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives", JOURNAL OF MEDICINAL CHEMISTRY , 23(8), 952-5 CODEN: JMCMAR; ISSN: 0022-2623, 1980, XP009139174
Attorney, Agent or Firm:
HOLLAND, Antonia, M. et al. (Dept. 0377 Bldg. AP6A-1A,100 Abbott Park Roa, Abbott Park Illinois, US)
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