Title:
MODULATORS OF CANNABINOID RECEPTORS
Document Type and Number:
WIPO Patent Application WO2005080316
Kind Code:
A3
Abstract:
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR<1> or NR<1>R<2> wherein each of R<1> and R<2> is independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO2-alkyl, alkenyl, CN, NH2, hydroxy, halo, alkoxy, CF3 and nitro; Y is a polar functional group selected from OH, NO2, CN, COR<3>, COOR<3>, NR<3>R<4>, CONR<3>R<4>, SO3H, SO2-R<3>, SO2NR<3>R<4> and CF3, where each of R<3> and R<4> is independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH2)n where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X-Y is other than meta-C=-C-(CH2)2CO2H, meta-C=-C-(CH2)2OH, meta-C=C-(CH2)2CO2Me, meta-(CH2)4CO2H, ortho-CH2CO2H, ortho-(CH2)2CO2H and ortho-(CH2)4CO2H; and (ii) when A is phenyl, n is 0, and Z is OMe, X-Y is other than meta-C=C-(CH2)4OH. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.
Inventors:
OKUYAMA MASAHIRO (JP)
SELWOOD DAVID (GB)
VISINTIN CRISTINA (GB)
BAKER DAVID (GB)
PRYCE GARETH (GB)
SELWOOD DAVID (GB)
VISINTIN CRISTINA (GB)
BAKER DAVID (GB)
PRYCE GARETH (GB)
Application Number:
PCT/GB2005/000605
Publication Date:
November 03, 2005
Filing Date:
February 21, 2005
Export Citation:
Assignee:
UNIV LONDON (GB)
OKUYAMA MASAHIRO (JP)
SELWOOD DAVID (GB)
VISINTIN CRISTINA (GB)
BAKER DAVID (GB)
PRYCE GARETH (GB)
OKUYAMA MASAHIRO (JP)
SELWOOD DAVID (GB)
VISINTIN CRISTINA (GB)
BAKER DAVID (GB)
PRYCE GARETH (GB)
International Classes:
C07C63/04; C07C69/76; C07C69/78; C07C233/11; C07C233/65; C07C233/66; C07C233/68; C07C233/69; C07C233/77; C07C235/42; C07C235/78; C07C235/84; C07C237/32; C07C237/38; C07C237/42; C07C255/41; (IPC1-7): C07C233/68; C07C233/77; C07C63/04; C07C69/78; A61K31/167; A61K31/192; A61K31/216; A61K31/235
Domestic Patent References:
| WO2004078180A2 | 2004-09-16 | |||
| WO2004074224A1 | 2004-09-02 | |||
| WO2003106420A1 | 2003-12-24 | |||
| WO2003091204A1 | 2003-11-06 | |||
| WO2000016756A2 | 2000-03-30 |
Foreign References:
| US5342971A | 1994-08-30 | |||
| US20030191069A1 | 2003-10-09 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OHSHIMA, ETSUO ET AL: "Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11- dihydrodibenz[b,e]oxepin derivatives", XP002333556, retrieved from STN Database accession no. 1992:255459
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ISHIKAWA, TADAHIRO ET AL: "Insulation film materials, varnishes containing them, polyoxazole-based microporous films with low moisture absorption manufactured from them, and semiconductor devices using them", XP002333557, retrieved from STN Database accession no. 2004:19987
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OREN, JAKOB ET AL: "Photochemical studies. Part 31. Homoconjugated ketones with extended unsaturation: wavelength-selective, regioselective, diastereoselective, and enantiospecific photochemical transformations of methyl 7-oxospiro[5.5]undeca-1,3- and -2,4-diene-2-carboxylate", XP002333558, retrieved from STN Database accession no. 1993:580433
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BERGMAN, NILS AAKE ET AL: "Chemical stability of a prostacyclin analog due to the absence of intramolecular catalysis", XP002333559, retrieved from STN Database accession no. 1988:221428
DATABASE BEILSTEIN [online] XP002333560, accession no. BRN 7478893
DATABASE BEILSTEIN [online] XP002333561, accession no. BRN 7705788
DATABASE BEILSTEIN [online] XP002333562, accession no. BRN 7704940
DATABASE BEILSTEIN [online] XP002333563, accession no. BRN 7434441
DATABASE BEILSTEIN [online] XP002333564, accession no. BRN 3414970
DATABASE BEILSTEIN [online] XP002333565, accession no. BRN 2803986
DATABASE BEILSTEIN [online] XP002333566, accession no. BRN 7478893
DATABASE BEILSTEIN [online] XP002333567, accession no. BRN 2576796
DATABASE BEILSTEIN [online] XP002333568, accession no. BRN 2093695
DATABASE BEILSTEIN [online] XP002333569, accession no. BRN 4862361
DATABASE BEILSTEIN [online] XP002333570, accession no. BRN 2720943
DATABASE BEILSTEIN [online] XP002333571, accession no. BRN 2578485
DATABASE BEILSTEIN [online] XP002333572, accession no. BRN 9028430
DATABASE BEILSTEIN [online] XP002333573, accession no. BRN 8102389
DATABASE BEILSTEIN [online] XP002333574, accession no. BRN 7884890
DATABASE BEILSTEIN [online] XP002333575, accession no. BRN 7884829
DATABASE BEILSTEIN [online] XP002333576, accession no. BRN 7595800
DATABASE BEILSTEIN [online] XP002333577, accession no. BRN 7157925
DATABASE BEILSTEIN [online] XP002333578, accession no. BRN 5989239
DATABASE BEILSTEIN [online] XP002333579, accession no. BRN 4000587
DATABASE BEILSTEIN [online] XP002333580, accession no. BRN 945016
DATABASE BEILSTEIN [online] XP002333583, accession no. BRN 433087
DATABASE BEILSTEIN [online] XP002333584, accession no. BRN 2381895
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ISHIKAWA, TADAHIRO ET AL: "Insulation film materials, varnishes containing them, polyoxazole-based microporous films with low moisture absorption manufactured from them, and semiconductor devices using them", XP002333557, retrieved from STN Database accession no. 2004:19987
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OREN, JAKOB ET AL: "Photochemical studies. Part 31. Homoconjugated ketones with extended unsaturation: wavelength-selective, regioselective, diastereoselective, and enantiospecific photochemical transformations of methyl 7-oxospiro[5.5]undeca-1,3- and -2,4-diene-2-carboxylate", XP002333558, retrieved from STN Database accession no. 1993:580433
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BERGMAN, NILS AAKE ET AL: "Chemical stability of a prostacyclin analog due to the absence of intramolecular catalysis", XP002333559, retrieved from STN Database accession no. 1988:221428
DATABASE BEILSTEIN [online] XP002333560, accession no. BRN 7478893
DATABASE BEILSTEIN [online] XP002333561, accession no. BRN 7705788
DATABASE BEILSTEIN [online] XP002333562, accession no. BRN 7704940
DATABASE BEILSTEIN [online] XP002333563, accession no. BRN 7434441
DATABASE BEILSTEIN [online] XP002333564, accession no. BRN 3414970
DATABASE BEILSTEIN [online] XP002333565, accession no. BRN 2803986
DATABASE BEILSTEIN [online] XP002333566, accession no. BRN 7478893
DATABASE BEILSTEIN [online] XP002333567, accession no. BRN 2576796
DATABASE BEILSTEIN [online] XP002333568, accession no. BRN 2093695
DATABASE BEILSTEIN [online] XP002333569, accession no. BRN 4862361
DATABASE BEILSTEIN [online] XP002333570, accession no. BRN 2720943
DATABASE BEILSTEIN [online] XP002333571, accession no. BRN 2578485
DATABASE BEILSTEIN [online] XP002333572, accession no. BRN 9028430
DATABASE BEILSTEIN [online] XP002333573, accession no. BRN 8102389
DATABASE BEILSTEIN [online] XP002333574, accession no. BRN 7884890
DATABASE BEILSTEIN [online] XP002333575, accession no. BRN 7884829
DATABASE BEILSTEIN [online] XP002333576, accession no. BRN 7595800
DATABASE BEILSTEIN [online] XP002333577, accession no. BRN 7157925
DATABASE BEILSTEIN [online] XP002333578, accession no. BRN 5989239
DATABASE BEILSTEIN [online] XP002333579, accession no. BRN 4000587
DATABASE BEILSTEIN [online] XP002333580, accession no. BRN 945016
DATABASE BEILSTEIN [online] XP002333583, accession no. BRN 433087
DATABASE BEILSTEIN [online] XP002333584, accession no. BRN 2381895
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