Title:
MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/099785
Kind Code:
A3
Abstract:
The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula (I) compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.
Inventors:
YIN HANG (US)
CHENG KUI (US)
CHENG KUI (US)
Application Number:
PCT/US2012/021207
Publication Date:
September 27, 2012
Filing Date:
January 13, 2012
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
YIN HANG (US)
CHENG KUI (US)
YIN HANG (US)
CHENG KUI (US)
International Classes:
C07D209/20; A61K31/381; A61K31/404; A61P31/00; C07D333/58
Domestic Patent References:
| WO2007030761A2 | 2007-03-15 | |||
| WO2003002533A1 | 2003-01-09 |
Foreign References:
| US6107329A | 2000-08-22 | |||
| US20040127527A1 | 2004-07-01 |
Other References:
DATABASE CID [online] 14 November 2007 (2007-11-14), XP003032764, accession no. PubChem NCBI Database accession no. 750453
Attorney, Agent or Firm:
CHA, Don D. (Golden, CO, US)
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