Title:
MODULATORS OF THE CX3CR1 RECEPTOR AND THERAPEUTIC USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/079063
Kind Code:
A3
Abstract:
The present invention concerns modulators of the CX3CR1 receptor. More specifically, antagonists and agonists of the CX3CR1 receptor have been identified. These antagonists and agonists can be used for treating an inflammatory disorder, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a graft versus host disease, a behavioral disorder, a cicatrisation disorder, a viral infection, cancer or pain. They may also be used as an adjuvant in a vaccine composition.
Inventors:
GOROCHOV GUY (FR)
DORGHAM KARIM (FR)
COMBADIERE CHRISTOPHE (FR)
DETERRE PHILIPPE (FR)
DORGHAM KARIM (FR)
COMBADIERE CHRISTOPHE (FR)
DETERRE PHILIPPE (FR)
Application Number:
PCT/EP2009/067325
Publication Date:
October 24, 2013
Filing Date:
December 16, 2009
Export Citation:
Assignee:
UNIV PARIS CURIE (FR)
GOROCHOV GUY (FR)
DORGHAM KARIM (FR)
COMBADIERE CHRISTOPHE (FR)
DETERRE PHILIPPE (FR)
GOROCHOV GUY (FR)
DORGHAM KARIM (FR)
COMBADIERE CHRISTOPHE (FR)
DETERRE PHILIPPE (FR)
International Classes:
C07K7/06; A61K38/02
Domestic Patent References:
| WO2000055207A1 | 2000-09-21 | |||
| WO2008003327A2 | 2008-01-10 | |||
| WO2010070394A1 | 2010-06-24 | |||
| WO2001060406A1 | 2001-08-23 | |||
| WO2002076990A1 | 2002-10-03 |
Foreign References:
| EP1734367A1 | 2006-12-20 |
Other References:
DELALEU N ET AL.: "Inhibition of experimental Sjogren's syndrome through immunization with Hsp60 and its peptide amino acids 437-460", ARTHRITIS & RHEUMATISM, vol. 58, no. 8, August 2008 (2008-08-01), JOHN WILEY & SONS, INC, US, pages 2318 - 2328, XP009122944, ISSN: 0004-3591, [retrieved on 20080730], DOI: 10.1002/ART.23656
ELICES M J ET AL.: "Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature", JOURNAL OF CLINICAL INVESTIGATION, vol. 93, no. 1, January 1994 (1994-01-01), AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, pages 405 - 416, XP009052418, ISSN: 0021-9738, DOI: 10.1172/JCI116975
INOUE A ET AL.: "Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice", ARTHRITIS & RHEUMATISM, vol. 52, no. 5, May 2005 (2005-05-01), JOHN WILEY & SONS, INC, US, pages 1522 - 1533, XP009122926, ISSN: 0004-3591, DOI: 10.1002/ART.21007
COMBADIERE C ET AL.: "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 37, 11 September 1998 (1998-09-11), AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, pages 23799 - 23804, XP002158116, ISSN: 0021-9258, DOI: 10.1074/JBC.273.37.23799
ELICES M J ET AL.: "Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature", JOURNAL OF CLINICAL INVESTIGATION, vol. 93, no. 1, January 1994 (1994-01-01), AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, pages 405 - 416, XP009052418, ISSN: 0021-9738, DOI: 10.1172/JCI116975
INOUE A ET AL.: "Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice", ARTHRITIS & RHEUMATISM, vol. 52, no. 5, May 2005 (2005-05-01), JOHN WILEY & SONS, INC, US, pages 1522 - 1533, XP009122926, ISSN: 0004-3591, DOI: 10.1002/ART.21007
COMBADIERE C ET AL.: "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 37, 11 September 1998 (1998-09-11), AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, pages 23799 - 23804, XP002158116, ISSN: 0021-9258, DOI: 10.1074/JBC.273.37.23799
Attorney, Agent or Firm:
JACOBSON, Claude et al. (2 Place d'Estienne d'Orves, Paris Cedex 09, FR)
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