MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS

Title:

MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS

Document Type and Number:

WIPO Patent Application WO2007016656

Kind Code:

A8

Abstract:

Methods for treatment of ocular disorders using steroids modulate the effects of local and systemic hypoxic events mediated by hypoxia inducible factor- 1 (HIF-1). Steroids that are useful as HIF-1 modulators include bufalin, digitoxigenin, digoxin, lanatoside C, strophantin K, uzarigenin, ouabain and proscillaridin. In some embodiments the ocular disorder is characterized by ischmia.

Inventors:

KHODADOUST MEHRAN (US)

Application Number:

PCT/US2006/030224

Publication Date:

July 19, 2007

Filing Date:

August 01, 2006

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Assignee:

BIONAUT PHARMACEUTICALS (US)
KHODADOUST MEHRAN (US)

International Classes:

A61K31/58; A61K31/585; C07J17/00; C07J41/00

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