MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF

Title:

MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2011/082400

Kind Code:

A3

Abstract:

Disclosed are an assay to identify modulators of the PD-1 :PD-L pathway and PD-1 :PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases influenced by modulation of the PD-1 :PD-L pathway such as, for example, autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, immune deficiency, and other immune system-related disorders, are also disclosed.

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Inventors:

SHARPE ARLENE H (US)
BUTTE MANISH J (US)
OYAMA SHINJI (US)

Application Number:

PCT/US2011/020046

Publication Date:

November 03, 2011

Filing Date:

January 03, 2011

Export Citation:

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Assignee:

HARVARD COLLEGE (US)
SHARPE ARLENE H (US)
BUTTE MANISH J (US)
OYAMA SHINJI (US)

International Classes:

C07D285/135; A61K31/433; A61K31/4412; A61P31/12; A61P35/00; A61P37/00; C07D213/72; C07D417/12

Domestic Patent References:

WO2007140222A2	2007-12-06
WO2007147883A1	2007-12-27

Other References:

DATABASE PUBCHEM COMPOUND [online] accession no. NCBI Database accession no. 231303

Attorney, Agent or Firm:

SMITH, DeAnn, F. et al. (Patent Group155 Seaport Boulevar, Boston MA, US)

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