Title:
MODULATORS OF ION CHANNEL TRPA1
Document Type and Number:
WIPO Patent Application WO2005089206
Kind Code:
A3
Abstract:
This invention provides methods for modulating activities of noxious ion channel TRPAI and methods for screening for novel modulators of TRPAI. Compounds such as bradykinin, eugenol, gingerol, methyl salicylate, allicin, and cinnamaldehyde can be employed to activate cold themosensor TRPAI. These TRPAI agonists can be used in screenings methods to activate TRPA1 and therefore identify novel TRPAI antagonists that can inhibit the activated TRPAI. These TRPAI agonists also provide chemical backbones to synthesize and identify analogs with improved biological or pharmaceutical properties. Further, novel TRPAI modulators can be identified by screening test agents for ability in modulating enzymatic activity or cellular level of phospholipase C.
Inventors:
PATAPOUTIAN ARDEM (US)
BANDELL MICHAEL (US)
STORY GINA M (US)
BANDELL MICHAEL (US)
STORY GINA M (US)
Application Number:
PCT/US2005/008105
Publication Date:
June 01, 2006
Filing Date:
March 11, 2005
Export Citation:
Assignee:
IRM LLC (US)
SCRIPPS RESEARCH INST (US)
PATAPOUTIAN ARDEM (US)
BANDELL MICHAEL (US)
STORY GINA M (US)
SCRIPPS RESEARCH INST (US)
PATAPOUTIAN ARDEM (US)
BANDELL MICHAEL (US)
STORY GINA M (US)
International Classes:
G01N33/53
Other References:
STORY G.M. ET AL: "ANKTM1, a TRP-like channel expresed in nociceptive neurons, is activated by cold temperatures.", CELL., vol. 112, no. 6, March 2003 (2003-03-01), pages 819 - 829, XP002279017
ROSENZWEIG M. ET AL: "The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.", GENES DEV., vol. 19, no. 4, 15 February 2005 (2005-02-15), pages 419 - 424, XP002996151, [retrieved on 20050128]
JORDT ET AL: "Mustard oils and cannabinoids excite sensory nerve fibres through the TPR channel ANLTM1.", NATURE., vol. 427, no. 6971, 15 January 2004 (2004-01-15), pages 260 - 265, XP002996152, [retrieved on 20040107]
COREY ET AL: "TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.", NATURE., vol. 432, no. 7018, 9 December 2004 (2004-12-09), pages 723 - 730, XP002996153, [retrieved on 20041013]
ROSENZWEIG M. ET AL: "The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.", GENES DEV., vol. 19, no. 4, 15 February 2005 (2005-02-15), pages 419 - 424, XP002996151, [retrieved on 20050128]
JORDT ET AL: "Mustard oils and cannabinoids excite sensory nerve fibres through the TPR channel ANLTM1.", NATURE., vol. 427, no. 6971, 15 January 2004 (2004-01-15), pages 260 - 265, XP002996152, [retrieved on 20040107]
COREY ET AL: "TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.", NATURE., vol. 432, no. 7018, 9 December 2004 (2004-12-09), pages 723 - 730, XP002996153, [retrieved on 20041013]
Download PDF:
Previous Patent: METHOD FOR RAISING FUNDS
Next Patent: SYSTEMS AND METHODS FOR DELIVERING A SAMPLE FLUID TO A RECEIVING SUBSTRATE
Next Patent: SYSTEMS AND METHODS FOR DELIVERING A SAMPLE FLUID TO A RECEIVING SUBSTRATE