Title:
MODULATORS OF LEUKOCYTE ACTIVATION, COMPOSITIONS, AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2003074007
Kind Code:
A3
Abstract:
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids and proteins which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
Inventors:
FRIERA ANNABELLE M (US)
VALLONE MARCY K (US)
WONG BRIAN (US)
MASUDA ESTEBAN (US)
POWELL MARK (US)
VALLONE MARCY K (US)
WONG BRIAN (US)
MASUDA ESTEBAN (US)
POWELL MARK (US)
Application Number:
PCT/US2003/006748
Publication Date:
October 28, 2004
Filing Date:
March 03, 2003
Export Citation:
Assignee:
RIGEL PHARMACEUTICALS INC (US)
FRIERA ANNABELLE M (US)
VALLONE MARCY K (US)
WONG BRIAN (US)
MASUDA ESTEBAN (US)
POWELL MARK (US)
FRIERA ANNABELLE M (US)
VALLONE MARCY K (US)
WONG BRIAN (US)
MASUDA ESTEBAN (US)
POWELL MARK (US)
International Classes:
C07K14/47; C12N5/02; G01N33/50; A61K38/00; (IPC1-7): C12N5/00; C12N5/02
Other References:
WIDOM R. ET AL.: "The hcKrox gene family regulates multiple extracellular matrix genes", MATRIX BIOLOGY, vol. 20, no. 7, 2001, pages 451 - 462
WIDOM R. ET AL.: "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression", GENE, vol. 198, no. 1-2, 1997, pages 407 - 420, XP004570121, DOI: doi:10.1016/S0378-1119(97)00360-0
WIDOM R. ET AL.: "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression", GENE, vol. 198, no. 1-2, 1997, pages 407 - 420, XP004570121, DOI: doi:10.1016/S0378-1119(97)00360-0
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