Title:
MOLECULAR CHAPERONE EXPRESSION INDUCER
Document Type and Number:
WIPO Patent Application WO/2007/125720
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition having an activity of inducing the
expression of an endoplasmic reticulum chaperone, which can be used effectively
for the prevention of the cell death caused by endoplasmic reticulum stress or
for the prevention of occurrence or progression of a neurodegenerative disease
or the amelioration of a neurodegenerative disease. The pharmaceutical composition
comprises a compound represented by the formula (I), a pharmaceutically acceptable
salt thereof, or a solvate of the compound or the salt, as an active ingredient.
(I) wherein R1 and R2 independently represent a
hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower
alkoxy group; Alk represents a lower alkylene chain; and X represents an oxygen
atom or a sulfur atom.
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Inventors:
KUDO TAKASHI (JP)
IMAIZUMI KAZUNORI (JP)
TAKEDA MASATOSHI (JP)
IMAIZUMI KAZUNORI (JP)
TAKEDA MASATOSHI (JP)
Application Number:
PCT/JP2007/057046
Publication Date:
November 08, 2007
Filing Date:
March 30, 2007
Export Citation:
Assignee:
UNIV OSAKA (JP)
UNIV MIYAZAKI (JP)
SHIONOGI & CO (JP)
KUDO TAKASHI (JP)
IMAIZUMI KAZUNORI (JP)
TAKEDA MASATOSHI (JP)
UNIV MIYAZAKI (JP)
SHIONOGI & CO (JP)
KUDO TAKASHI (JP)
IMAIZUMI KAZUNORI (JP)
TAKEDA MASATOSHI (JP)
International Classes:
A61K31/26; A61P3/10; A61P9/10; A61P25/00; A61P25/16; A61P25/28; A61P27/06; A61P43/00
Domestic Patent References:
| WO2004110418A2 | 2004-12-23 |
Foreign References:
| DE1131461B | 1962-06-14 |
Other References:
PIHLAJA K. ET AL.: "A correlative IR, MS, 1H, 13C and 15N NMR and theoretical study of 4-arylthiazol-2(3H)-ones", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, no. 2, 2002, pages 329 - 336, XP003018933
KUDO T.: "Shohotai Stress Han'no o Fumaeta Alzheimer-byo no Atarashii Chiryo Senryaku", HEISEI 15 NENDO SOKATSU.BUNTAN KENKYU HOKOKUSHO, April 2004 (2004-04-01), pages 27 - 29, XP003018934
KUDO T. ET AL.: "Bunshi Chaperone Yudozai no Shinkei Hensei Shikkan Chiryo eno Oyo (A molecular chaperone inducer as potential therapeutic agent for neurodegenerative diseases)", JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY (JPN. J. NEUROPSYCHOPHARMACOL.), vol. 27, no. 2, 25 April 2007 (2007-04-25), pages 63 - 67, XP003018935
KUDO T. ET AL.: "Alzheimer-byo Shindan.Chiryo no Atarashii Tenkai Chiryoyaku Kaihatsu Shohotai Stress no Chaperone Yudo", PHARMA MEDICA, vol. 24, no. 7, 10 July 2006 (2006-07-10), pages 59 - 62, XP003018936
KUDO T.: "Shohotai Stress Han'no o Fumaeta Alzheimer-byo no Atarashii Chiryo Senryaku", HEISEI 15 NENDO SOKATSU.BUNTAN KENKYU HOKOKUSHO, April 2004 (2004-04-01), pages 27 - 29, XP003018934
KUDO T. ET AL.: "Bunshi Chaperone Yudozai no Shinkei Hensei Shikkan Chiryo eno Oyo (A molecular chaperone inducer as potential therapeutic agent for neurodegenerative diseases)", JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY (JPN. J. NEUROPSYCHOPHARMACOL.), vol. 27, no. 2, 25 April 2007 (2007-04-25), pages 63 - 67, XP003018935
KUDO T. ET AL.: "Alzheimer-byo Shindan.Chiryo no Atarashii Tenkai Chiryoyaku Kaihatsu Shohotai Stress no Chaperone Yudo", PHARMA MEDICA, vol. 24, no. 7, 10 July 2006 (2006-07-10), pages 59 - 62, XP003018936
Attorney, Agent or Firm:
SAEGUSA, Eiji et al. (1-7-1 Doshomachi,,Chuo-ku,,Osaka-shi, Osaka45, JP)
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