Title:
MOLECULAR FLUOROPHORES AND PREPARATION METHOD THEREOF AND USE FOR SHORT WAVELENGTH INFRARED IMAGING
Document Type and Number:
WIPO Patent Application WO/2017/190345
Kind Code:
A1
Abstract:
Provided is the design, synthesis and applications of molecular fluorophores for bioimaging in the short wavelength infrared window (1000-1700 nm). The molecular fluorophores compound comprise structures with electron accepting aromatic units, electron donating aromatic units, and an shielding units which shield the conjugated backbones from intermolecular interactions.
Inventors:
LIANG YONGYE (CN)
WANG HUASEN (CN)
YANG QINGLAI (CN)
TANG MEIJIE (US)
ZHAO SU (US)
WANG HUASEN (CN)
YANG QINGLAI (CN)
TANG MEIJIE (US)
ZHAO SU (US)
Application Number:
PCT/CN2016/081265
Publication Date:
November 09, 2017
Filing Date:
May 06, 2016
Export Citation:
Assignee:
UNIV SOUTH SCIENCE & TECHNOLOGY CHINA (CN)
NIRMIDAS BIOTECH INC (US)
NIRMIDAS BIOTECH INC (US)
International Classes:
A61K49/00; C07D513/04; C07D487/04; C07D498/04; C07D517/04
Domestic Patent References:
| WO2016112220A1 | 2016-07-14 | |||
| WO2014107606A2 | 2014-07-10 | |||
| WO2015012913A2 | 2015-01-29 | |||
| WO2015041026A1 | 2015-03-26 |
Foreign References:
| US20150295182A1 | 2015-10-15 |
Other References:
QIAN, G . ET AL.: "Band Gap Tunable, Donor-Acceptor-Donor Charge-Transfer Heteroquinoid-Based Chromophores: Near Infrared Photoluminescence and Electroluminescence", CHEM. MATER ., vol. 20, no. 19, 18 September 2008 (2008-09-18), pages 6208 - 6216, XP055435804
QIAN, G. ET AL.: "Design, synthesis, and properties of benzobisthiadiazole-based donor-pi- acceptor-Jt-donor type of low-band-gap chromophores and polymers", CHEM. MATER., vol. 88, 19 January 2010 (2010-01-19), pages 192 - 201, XP008177745
ANTARIS A.L. ET AL.: "A small-molecule dye for NIR-II imaging", NATURE MATERIALS, vol. 15, 29 February 2016 (2016-02-29), pages 235 - 243, XP055420687
FENG G.X. ET AL.: "Conjugated polymer microparticles for selective cancer cell image-guided photothermal therapy", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, 3 December 2014 (2014-12-03), pages 1135 - 1141, XP055435805
QIAN, G. ET AL.: "Design, synthesis, and properties of benzobisthiadiazole-based donor-pi- acceptor-Jt-donor type of low-band-gap chromophores and polymers", CHEM. MATER., vol. 88, 19 January 2010 (2010-01-19), pages 192 - 201, XP008177745
ANTARIS A.L. ET AL.: "A small-molecule dye for NIR-II imaging", NATURE MATERIALS, vol. 15, 29 February 2016 (2016-02-29), pages 235 - 243, XP055420687
FENG G.X. ET AL.: "Conjugated polymer microparticles for selective cancer cell image-guided photothermal therapy", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, 3 December 2014 (2014-12-03), pages 1135 - 1141, XP055435805
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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