Title:
MOLECULAR IMAGING PROBES FOR DIAGNOSING CONFORMATION DISEASE
Document Type and Number:
WIPO Patent Application WO/2013/027694
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a near infrared light-emitting compound which has an ability to highly specifically binding to Aβ, a high permeability through the blood-brain barrier, an ability to quickly disappear from the brain and a high biopermeability. Provided are a compound having a benzoxazole skeleton and an aromatic compound having a dimethylamino group, a dicyanovinyl group, etc. In formula (I), either R1 or R2 is an electron donating group and the other is an electron withdrawing group; X and Y are the same or different and each represents a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom; and m is an integer of 0 to 5.
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Inventors:
SAJI HIDEO (JP)
ONO MASAHIRO (JP)
CUI MENGCHAO (JP)
ONO MASAHIRO (JP)
CUI MENGCHAO (JP)
Application Number:
PCT/JP2012/070978
Publication Date:
February 28, 2013
Filing Date:
August 20, 2012
Export Citation:
Assignee:
UNIV KYOTO (JP)
SAJI HIDEO (JP)
ONO MASAHIRO (JP)
CUI MENGCHAO (JP)
SAJI HIDEO (JP)
ONO MASAHIRO (JP)
CUI MENGCHAO (JP)
International Classes:
C07C255/42; A61K49/00; A61K51/00; C07D263/56; C07D277/64; C07D307/66; C07D333/36
Domestic Patent References:
| WO2007041241A2 | 2007-04-12 |
Foreign References:
| JP2010189359A | 2010-09-02 | |||
| JP2004506723A | 2004-03-04 | |||
| JP2003531133A | 2003-10-21 | |||
| JP2008546804A | 2008-12-25 | |||
| JP2009516649A | 2009-04-23 |
Other References:
LAPORTE,S.L. ET AL.: "The application of malononitriles as microviscosity probes in pharmaceutical systems", PHARMACEUTICAL RESEARCH, vol. 12, no. 3, 1995, pages 380 - 6, XP002954839, DOI: doi:10.1023/A:1016252518401
LEE,H.S. ET AL.: "Chemometric studies on brain-uptake of PET agents via VolSurf analysis", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 29, no. 1, 2008, pages 61 - 68
FERRIGHI,L. ET AL.: "Density-functional-theory study of the electric-field-induced second harmonic generation (EFISHG) of push-pull phenylpolyenes in solution", CHEMICAL PHYSICS LETTERS, vol. 425, no. 4-6, 2006, pages 267 - 272, XP027876658, DOI: doi:10.1016/j.cplett.2006.04.112
HROBARIK,P. ET AL.: "Computational design of benzothiazole-derived push-pull dyes with high molecular quadratic hyperpolarizabilities", PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 6, no. 3, 2004, pages 495 - 502
GRACZA,T. ET AL.: "New method of preparation of 5-(dimethylamino)-2-furylethylenes via furan vinamidinium salts", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 51, no. 4, 1986, pages 879 - 88
LEE,H.S. ET AL.: "Chemometric studies on brain-uptake of PET agents via VolSurf analysis", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 29, no. 1, 2008, pages 61 - 68
FERRIGHI,L. ET AL.: "Density-functional-theory study of the electric-field-induced second harmonic generation (EFISHG) of push-pull phenylpolyenes in solution", CHEMICAL PHYSICS LETTERS, vol. 425, no. 4-6, 2006, pages 267 - 272, XP027876658, DOI: doi:10.1016/j.cplett.2006.04.112
HROBARIK,P. ET AL.: "Computational design of benzothiazole-derived push-pull dyes with high molecular quadratic hyperpolarizabilities", PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 6, no. 3, 2004, pages 495 - 502
GRACZA,T. ET AL.: "New method of preparation of 5-(dimethylamino)-2-furylethylenes via furan vinamidinium salts", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 51, no. 4, 1986, pages 879 - 88
Attorney, Agent or Firm:
NOMURA, Kenichi et al. (JP)
Ken-ichi Nomura (JP)
Ken-ichi Nomura (JP)
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