Title:
MOLECULAR MARKER FOR EARLY PANCREATIC NEOPLASM DETECTION, DETECTION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/218592
Kind Code:
A1
Abstract:
Disclosed are a molecular marker for early pancreatic neoplasm detection, a detection method therefor and an application thereof. The pancreatic cancer-related molecular marker comprises: miR-30c, miR-24, miR-23a, and miR-132. The combination of molecular markers, the method, and the kit provided by the present invention can be used in screening and differential diagnosis of early pancreatic cancer, monitoring of disease complications occurrence and recurrence, and evaluations such as the pharmaceutical efficacy, the efficacy, and the accurate medication guidance.
Inventors:
XIAO XIAOYING (CN)
XIAO GUISHAN (CN)
XIAO GUISHAN (CN)
Application Number:
PCT/CN2021/086188
Publication Date:
November 04, 2021
Filing Date:
April 09, 2021
Export Citation:
Assignee:
KANTE SHENZHEN BIOTECHNOLOGIES INC (CN)
KANTE DALIAN BIOTECHNOLOGIES INC (CN)
KANTE DALIAN BIOTECHNOLOGIES INC (CN)
International Classes:
C12N15/11; C12Q1/6886
Foreign References:
| CN109423519A | 2019-03-05 | |||
| CN101384273A | 2009-03-11 | |||
| CN101389770A | 2009-03-18 | |||
| CN111575374A | 2020-08-25 |
Other References:
SUN LULU ET AL.: "MicroRNA-30c inhibits pancreatic cancer cell proliferation by targeting twinfilin 1 and indicates a poor prognosis.", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 25, no. 42, 14 November 2019 (2019-11-14), pages 6311 - 6321, XP055866795
HUANG WENJIE, GU JIANYOU, TAO TIAN, ZHANG JUNFENG, WANG HUAIZHI, FAN YINGFANG: "MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation.", FRONTIERS IN ONCOLOGY, vol. 9, 21 January 2020 (2020-01-21), pages 1 - 12, XP055866796
CHAO JIADENG, JIN LEI, ZHANG XUDONG, DING DONG, WU SIYUAN, MA LE, ZHU BEI, SHAN SHITING, YUN XIAO, GAO PENG, LI JUN, ZHU CHUNFU, Q: "Insight into the effects of microRNA-23a-3p on pancreatic cancer and its underlying molecular mechanism.", ONCOLOGY LETTERS, vol. 19, no. 1, 31 January 2020 (2020-01-31), pages 187 - 194, XP055866800
PARK JONG, DOSEFF ANDREA, SCHMITTGEN THOMAS: "MicroRNAs Targeting Caspase-3 and-7 in PANC-1 Cells.", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 1206, 30 April 2018 (2018-04-30), pages 1 - 12, XP055866804
HUANG WENJIE, GU JIANYOU, TAO TIAN, ZHANG JUNFENG, WANG HUAIZHI, FAN YINGFANG: "MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation.", FRONTIERS IN ONCOLOGY, vol. 9, 21 January 2020 (2020-01-21), pages 1 - 12, XP055866796
CHAO JIADENG, JIN LEI, ZHANG XUDONG, DING DONG, WU SIYUAN, MA LE, ZHU BEI, SHAN SHITING, YUN XIAO, GAO PENG, LI JUN, ZHU CHUNFU, Q: "Insight into the effects of microRNA-23a-3p on pancreatic cancer and its underlying molecular mechanism.", ONCOLOGY LETTERS, vol. 19, no. 1, 31 January 2020 (2020-01-31), pages 187 - 194, XP055866800
PARK JONG, DOSEFF ANDREA, SCHMITTGEN THOMAS: "MicroRNAs Targeting Caspase-3 and-7 in PANC-1 Cells.", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 1206, 30 April 2018 (2018-04-30), pages 1 - 12, XP055866804
Attorney, Agent or Firm:
DALIAN CHICCO PATENT OFFICE (CN)
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