Title:
MOLECULAR MODULE
Document Type and Number:
WIPO Patent Application WO/2008/069232
Kind Code:
A1
Abstract:
It is intended to provide a general-purpose experimental tool capable of specifically
binding to a polymer which becomes a receptor for a specific ligand such as a medicament
and applicable throughout various processes for searching properties thereof.
In order to achieve this object, a molecular module which binds to a target compound
and is used for purifying or labeling the compound was developed. The molecular
module is characterized in that it has a rod-like structural substance, an interacting
substance which interacts with a target compound, a tag and a labeling substance,
the interacting substance is located at one end of the rod-like structural substance,
and the tag and the labeling substance are located at the other end of the rod-like
structural substance.
Inventors:
KATAYAMA EISAKU (JP)
MURAYAMA TAKASHI (JP)
KASHIYAMA TAKU (JP)
KOBAYASHI TAKUYA (JP)
MURAYAMA TAKASHI (JP)
KASHIYAMA TAKU (JP)
KOBAYASHI TAKUYA (JP)
Application Number:
PCT/JP2007/073482
Publication Date:
June 12, 2008
Filing Date:
December 05, 2007
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV JUNTENDO (JP)
KATAYAMA EISAKU (JP)
MURAYAMA TAKASHI (JP)
KASHIYAMA TAKU (JP)
KOBAYASHI TAKUYA (JP)
UNIV JUNTENDO (JP)
KATAYAMA EISAKU (JP)
MURAYAMA TAKASHI (JP)
KASHIYAMA TAKU (JP)
KOBAYASHI TAKUYA (JP)
International Classes:
C07K19/00; G01N33/566; C12N15/09; G01N33/58
Foreign References:
| JP2006343207A | 2006-12-21 | |||
| JP2006332530A | 2006-12-07 |
Other References:
KATAYAMA E.: "Bunshi o Miru: Denshi Kenbikyo ni yoru Tanpakushitsu Fukugotai no Kansatsubo", CELL TECHNOLOGY, vol. 26, April 2007 (2007-04-01), pages 438 - 443, XP008110998
GIBBONS I.R. ET AL.: "The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk", J. BIOL. CHEM., vol. 280, 2005, pages 23960 - 23965, XP008109109
DJINOVIC-CARUGO K. ET AL.: "Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments", CELL, vol. 98, 1999, pages 537 - 546, XP008109108
SMITH C.J. AND PEARSE B.M.: "Clathrin: anatomy of a coat protein", TRENDS CELL BIOL., vol. 9, 1999, pages 335 - 338, XP008109116
MEDALIA O. ET AL.: "Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography", SCIENCE, vol. 298, 2002, pages 1209 - 1213, XP008109110
KATAYAMA E. ET AL.: "Native structure and arrangement of inositol-1,4,5-triphosphate receptor molecules in bovine cerebellar Purkinje cells as studied by quick-freeze deep-etch electron microscopy", EMBO J., vol. 15, 1996, pages 4844 - 4851, XP008109117
See also references of EP 2098538A4
CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 11, 2001, pages 450 - 457
GIBBONS I.R. ET AL.: "The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk", J. BIOL. CHEM., vol. 280, 2005, pages 23960 - 23965, XP008109109
DJINOVIC-CARUGO K. ET AL.: "Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments", CELL, vol. 98, 1999, pages 537 - 546, XP008109108
SMITH C.J. AND PEARSE B.M.: "Clathrin: anatomy of a coat protein", TRENDS CELL BIOL., vol. 9, 1999, pages 335 - 338, XP008109116
MEDALIA O. ET AL.: "Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography", SCIENCE, vol. 298, 2002, pages 1209 - 1213, XP008109110
KATAYAMA E. ET AL.: "Native structure and arrangement of inositol-1,4,5-triphosphate receptor molecules in bovine cerebellar Purkinje cells as studied by quick-freeze deep-etch electron microscopy", EMBO J., vol. 15, 1996, pages 4844 - 4851, XP008109117
See also references of EP 2098538A4
CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 11, 2001, pages 450 - 457
Attorney, Agent or Firm:
NOMURA, Kenichi et al. (30-1 Tsuruyacho 3-chome, Kanagawa-k, Yokohama-shi Kanagawa 35, JP)
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