Title:
MOLECULARLY IMPRINTED POLYMERS FOR THE CAPTURE OF BIOTIN
Document Type and Number:
WIPO Patent Application WO/2014/030002
Kind Code:
A3
Abstract:
The present invention refers to new classes of polymerisable monomers targeting biotin, a biotin derivative, a biotin analogue or a biotinylated molecule and related structures, as well as molecularly imprinted polymers obtainable by polymerisation of at least one of these monomers and at least one cross-linking monomer in the presence of a suitable template molecule. The obtained polymers may be used for separation of biotin and related small molecules, together with larger biotinylated molecules of biological origin, e.g. proteins, from complex mixtures. The monomer comprises i) an isophthalic acid derivative or a pyridine-2,6-dicarboxylic acid derivative and ii) a vinyl-2- aminopyridine derivative
Inventors:
HALL ANDREW (GB)
Application Number:
PCT/GB2013/052214
Publication Date:
July 10, 2014
Filing Date:
August 22, 2013
Export Citation:
Assignee:
UNIV KENT CANTERBURY (GB)
International Classes:
C07D401/14; C07D401/12; C07D495/04; C08F226/06; G01N33/50
Other References:
ELENA PILETSKA ET AL: "Biotin-specific synthetic receptors prepared using molecular imprinting", ANALYTICA CHIMICA ACTA, vol. 504, no. 1, 1 February 2004 (2004-02-01), pages 179 - 183, XP055088498, ISSN: 0003-2670, DOI: 10.1016/S0003-2670(03)00813-4
JESPER WIKLANDER ET AL: "Towards a synthetic avidin mimic", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 400, no. 5, 27 March 2011 (2011-03-27), pages 1397 - 1404, XP055088496, ISSN: 1618-2642, DOI: 10.1007/s00216-011-4907-5
TOSHIFUMI TAKEUCHI ET AL: "Molecular Imprinting of Biotin Derivatives and Its Application to Competitive Binding Assay Using Nonisotopic Labeled Ligands", ANALYTICAL CHEMISTRY, vol. 72, no. 11, 1 June 2000 (2000-06-01), pages 2418 - 2422, XP055088497, ISSN: 0003-2700, DOI: 10.1021/ac991357s
JESPER WIKLANDER ET AL: "Towards a synthetic avidin mimic", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 400, no. 5, 27 March 2011 (2011-03-27), pages 1397 - 1404, XP055088496, ISSN: 1618-2642, DOI: 10.1007/s00216-011-4907-5
TOSHIFUMI TAKEUCHI ET AL: "Molecular Imprinting of Biotin Derivatives and Its Application to Competitive Binding Assay Using Nonisotopic Labeled Ligands", ANALYTICAL CHEMISTRY, vol. 72, no. 11, 1 June 2000 (2000-06-01), pages 2418 - 2422, XP055088497, ISSN: 0003-2700, DOI: 10.1021/ac991357s
Attorney, Agent or Firm:
BOXALL IPM LTD (Sandwich, Kent CT13 9BT, GB)
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