Title:
MOLECULES DESIGNATED B7L-1
Document Type and Number:
WIPO Patent Application WO2000008057
Kind Code:
A3
Abstract:
The invention is directed to B7L-1 as a purified and isolated protein, the DNA encoding the B7L-1, host cells transfected with cDNAs encoding B7L-1 and processes for preparing B7L-1 polypeptides.
Inventors:
BAUM PETER ROBERT (US)
Application Number:
PCT/US1999/017906
Publication Date:
May 18, 2000
Filing Date:
August 05, 1999
Export Citation:
Assignee:
IMMUNEX CORP (US)
BAUM PETER ROBERT (US)
BAUM PETER ROBERT (US)
International Classes:
C07K14/705; A61K38/00; (IPC1-7): C12N15/62; C07K14/705; C12Q1/68
Domestic Patent References:
| WO1998044113A1 | 1998-10-08 |
Other References:
DATABASE GENBANK 10 October 1995 (1995-10-10), HILLIER L.: "ym90f09.r1 Homo sapiens cDNA clone 166217", XP002132878
FREEMAN G J ET AL: "B7, A NEW MEMBER OF THE IG SUPERFAMILY WITH UNIQUE EXPRESSION ON ACTIVATED AND NEOPLASTIC B CELLS", JOURNAL OF IMMUNOLOGY,US,THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 143, no. 8, 15 October 1989 (1989-10-15), pages 2714 - 2722, XP000561211, ISSN: 0022-1767
FARGEAS C A ET AL: "IDENTIFICATION OF RESIDUES IN THE V DOMAIN OF CD80 (B7-1) IMPLICATED IN FUNCTIONAL INTERACTIONS WITH CD28 AND CTLA4", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 182, 1 September 1995 (1995-09-01), pages 667 - 675, XP002912153, ISSN: 0022-1007
LINSLEY P.S. ET AL.: "Binding stoichiometry of the cytotoxic T lymphocyte-associated Molecule-4 (CTLA-4).", J. BIOL. CHEM., vol. 270, no. 25, 23 June 1995 (1995-06-23), pages 15417 - 15424, XP002129410
GREENE J.A. ET AL.: "Covalent dimerization of CD28/CTLA4 and oligomoerization of CD80/CD86 regulate T cell costimulatory interactions.", J. BIOL. CHEM., vol. 271, no. 43, 25 October 1996 (1996-10-25), pages 26762 - 26771, XP002129411
FREEMAN G J ET AL: "B7, A NEW MEMBER OF THE IG SUPERFAMILY WITH UNIQUE EXPRESSION ON ACTIVATED AND NEOPLASTIC B CELLS", JOURNAL OF IMMUNOLOGY,US,THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 143, no. 8, 15 October 1989 (1989-10-15), pages 2714 - 2722, XP000561211, ISSN: 0022-1767
FARGEAS C A ET AL: "IDENTIFICATION OF RESIDUES IN THE V DOMAIN OF CD80 (B7-1) IMPLICATED IN FUNCTIONAL INTERACTIONS WITH CD28 AND CTLA4", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 182, 1 September 1995 (1995-09-01), pages 667 - 675, XP002912153, ISSN: 0022-1007
LINSLEY P.S. ET AL.: "Binding stoichiometry of the cytotoxic T lymphocyte-associated Molecule-4 (CTLA-4).", J. BIOL. CHEM., vol. 270, no. 25, 23 June 1995 (1995-06-23), pages 15417 - 15424, XP002129410
GREENE J.A. ET AL.: "Covalent dimerization of CD28/CTLA4 and oligomoerization of CD80/CD86 regulate T cell costimulatory interactions.", J. BIOL. CHEM., vol. 271, no. 43, 25 October 1996 (1996-10-25), pages 26762 - 26771, XP002129411
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