Molecules having pesticidal! utility,

and intermediates, compositions, and processes, related thereto

Cross-references to related applications

This Application clai ms the benefit of, and priority from, U .S. provisional applications serial numbers 62/407092 and 62/407118; all of which were filed on October 12, 2016. The entire contents of all of the above-identified applications are hereby incorporated by reference into this Application ,

Field of this disclosure

This disclosure relates to the field of moiecuies having pesticidal utility against pests in Phyla Arthropoda, Moll usca, and Nematoda, processes to produce such moiecuies, intermediates used in such processes, pesticidal compositions containing such moiecuies, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, i nsecticides, m!ticides, mol luscicides, and nematicides.

Background of this disclosure

"Many of the most dangerous human diseases are transmitted by i nsect vectors" (Rivero et a! ,) , "Historically, maiarla, dengue, yellow fever, piague, filarlasis, louse- borne typhus, trypanomiasis, leishmaniasis, and other vector borne diseases were responsible for more human disease and death in the 17 ^th through the early 20 ^th centuries than all other causes combi ned" (Gub!er) , Vector-borne diseases are responsible for about 17% of the global parasitic and infectious diseases. Malaria alone causes over 800,000 deaths a year, 85% of which occur i n children under five years of age. Each year there are about 50 to about 100 million cases of dengue fever, A further 250,000 to 500,000 cases of dengue hemorrhagic fever occur each year (Matthews) . Vector control plays a critical role in the prevention and control of infectious diseases. However, insecticide resistance, inciuding resistance to multiple insecticides, has arisen in all insect species that are major vectors of human diseases (Rivero et a! .) . Recently, more than 550 arthropod species ave developed resistance to at least one pesticide (VVhalon et a! ,} , Furthermore, the cases of insect resistance continue to exceed by far the number of cases of herbicide and fungicide resistance (Sparks et al .) .

Each year insects, plant pathogens, and weeds, destroy more than 40% of ail food production. This loss occurs despite the application of pesticides and the use of a wide array of non-chemical controls, such as, crop rotations, and biological controls. If just some of this food could be saved, it could be used to feed the more than three billion people in the world who are mal nourished (Pimental) .

Plant parasitic nematodes are among the most widespread pests, and are frequently one of the most insidious and costly, It has been estimated that losses attributable to nematodes are from about 9% in developed countries to about 15% in undeveloped countries. However, in the United States of America a survey of 35 States on various crops indicated nematode-derived losses of up to 25% (N icol et al . ).

It is noted that gastropods (slugs and snails) are pests of less economic importance than other arthropods or nematodes, but in certain places, they may reduce yields substantially, severely affecting the quality of harvested products, as well as, transmitting human, animal, and plant diseases. While only a few dozen species of gastropods are serious regional pests, a handful of species are important pests on a worldwide scale, In particular, gastropods affect a wide variety of agricultural and horticultural crops, such as, arable, pastoral, and fiber crops; vegetables; bush and tree fruits; herbs; and ornamentals (Speiser) .

Termites cause damage to all types of private and public structures, as well as to agricultural and forestry resources. In 2005, it was estimated that termites cause over US$50 billion in damage worldwide each year (Korb) .

Consequently, for many reasons, includi ng those mentioned above, there is an on-going need for the costly (esti mated to be about US$256 million per pesticide in 2010), ti me-consuming (on average about 10 years per pesticide), and difficult, development of new pesticides (CropLife America).

Certain references cited n this disciosure

CropLife America, The Cost of New Agrochemicai Product Discovery, Development

& Registration, and Research & Development predictions for the Future, 2010.

Drewes, M ., Tletjen, K., Sparks, T.C. , High-Throughput Screening i n

Agrochemicai Research, Modern Methods in Crop Protection Research, Part I, Methods for the Design and Optimization of New Active Ingredients, Edited by Jeschke, P., Kramer, W., Schirmer, U. , and Matthias VV,, p. 1-20, 2012,

Gubler, D., Resurgent Vector-Borne Diseases as a Global Health Problem, Emerging Infectious Diseases, Vol . 4, No. 3, p. 442-450, 1998.

Korb, J . , Termites, Current Biology, Vol . 17, No. 23, 2007.

Matthews, G., Integrated Vector Management: Control ling Vectors of Malaria and Other Insect Vector Borne Diseases, Ch. 1, p. 1 , 2011.

Nicol, J ,, Turner S., Coyne, L, den Nijs, L, Hocksland, L, Tahna-Maafi, Z., Current Nematode Threats to World Agriculture, Genomic and Molecular Genetics of Plant - Nematode Interactions, p. 21-43, 2011.

Pimental, D,, Pest Control in World Agriculture, Agricultural Sciences - Vol , II, 2009.

Rivero, A., Vezi!ier, J, , Wei ll, M . , Read, A. , Gandon, S., Insect Control of Vector- Borne Diseases: When Is Insect Resistance a Problem? Public Library of Science

Pathogens, Vol . 6, No. 8, p. 1-9, 2010. Sparks T.C., Nauen R., IRAC ; Mode of action classification and insecticide resistance management, Pesticide Biochemistry and Physiology (2014) available online 4 December 2014,

Speiser, B., Moliuscicldes, Encyclopedia of Pest Management, Ch, 219, p. 506- 508, 2002.

Wha!on, M ., Mota -Sanchez, D. , Hollingworth, R., Analysis of Global Pesticide Resistance in Arthropods, Global Pesticide Resistance in Arthropods, Ch. 1, p. 5-33, 2008.

Definitions used in this disclosure

The examples given i n these definitions are generally non-exhaustive and must not be construed as limiting this disclosure. It is understood that a substituent should comply with chemical bonding rules and steric compati bility constraints i n relation to the particular molecule to which it is attached . These definitions are only to be used for the purposes of this disclosure.

The phrase "active ingredient" means a material having activity useful in controlling pests, and/or that is useful In hel ping other materials have better activity in controlling pests, examples of such materials include, but are not li mited to, acaricides, aigicides, antifeedants, avicides, bactericides, bird repellents, chemosteriiants, fungicides, herbicide safeners, herbicides, insect attractants, insect repellents, insecticides, mammal repellents, mating disrupters, mol iuscicldes, nematicides, plant activators, plant growth regulators, rodenticides, synergists, and virucides (see alanwood. net) . Specific examples of such materials include, but are not li mited to, the materials listed I n active i ngredient group alpha .

The phrase "active ingredient group aipha" (hereafter "AIGA") means col lectively the following materials:

( I) (3-ethoxypropyl)mercury bromide, 1,2-dibromoethane, 1,2- dich!oroethane, 1,2-dichloropropane, 1,3-dichloropropene, 1-MCP, 1- methylcyciopropene, 1-naphthol, 2-(octylthio)ethanol, 2,3,3-TPA, 2,3,5-tri-iodobenzoic acid, 2,3,6-TBA, 2,4,5-T, 2,4,5-TB, 2,4,5-TP, 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 2,4- DES, 2,4-DP, 2,4-MCPA, 2,4-MCPB, 2iP, 2-methoxyethylmercury chloride, 2- phenylphenol, 3,4-DA, 3,4-DB, 3,4-DP, 3,6-dichloropicolinic acid, 4-ami nopyridine, 4~ CPA, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol, 8-hydroxyqui noline sulfate, 8- phenylmercurioxyquinoline, abamectl n, abamectin-aminomethyi, abscisic acid, ACC, acephate, acequinocyl, acetami prid, acethion, acetochior, acetofenate, acetophos, acetoproie, acibenzo!ar, acifl uorfen, aclonifen, ACN, acrep, acrinathrin, acrolein, acryionitrlle, acypetacs, afidopyropen, afoxolaner, alachlor, alanap, alanycarb, albendazole, aldicarb, aldlcarb suifone, aldimorph, aldoxycarb, a!drin, allethrin, aiilcin, a!iidochlor, aiiosamidln, alloxydim, ally! alcohol, allyxycarb, aiorac, a/pfta-cypermethrin, a/p/73-endosu!fan, al phamethrin, altretamine, alumini um phosphide, aluminum phosphide, ametoctradin, ametridione, ametryn, ametryne, amibuzin, amicarbazone, amicarthiazol, amidithlon, amidoflumet, amidosulfuron, aminocarb, aminocyclopyrachlor, aminopyralid, aminotriazole, ami profos-methyl, amiprophos, amiprophos-methyi, amisulbrom, amiton, amitraz, amitrole, ammonium sulfamate, amobam, amorphous silica gel, amorphous si licon dioxide, ampropy!fos, AMS, anabasine, ancymidol, anilazi ne, aniiofos, anisuron, anthraquinone, antu, apholate, aramlte, arprocarb, arsenous oxide, asomate, aspirin, asulam, athidathion, atraton, atrazine, aureofungin, avermectin B l, AVG, aviglycine, azaconazoie, azadirachtin, azafenidin, azamethi phos, azidithion, azimsulfuron, azi nphosethyl, azinphos-ethyi, azinphosmethyi, azi nphos-methyl, aziprotryn, azi protryne, azithiram, azobenzene, azocyciotin, azothoate, azoxystrobin, bachmedesh, barban, barbanate, barium hexafluorosilicate, barium po!ysuifide, barium siiicofluoride, barthrin, basic copper carbonate, basic copper chloride, basic copper sulfate, BCPC, bef!ubutamid, bena!axy!, bena!axy!-M, benazolin, bencarbazone, benc!othiaz, bendaqingbi ngzhi, bendiocarb, bendioxide, benefln, benflura!in,

benfuracarb, benfuresate, ben i huangcaoan, benodanii, benomyl, benoxacor, benoxafos, benqul nox, bensuifuron, bensuilde, bensultap, benta! uron, bentazon, bentazone, benthiavaiicarb, benthiazole, benthiocarb, bentranii, benzadox, benzaikoni um chloride, benzamacri l, benzamizole, benzamorf, benzene hexachloride, benzfendizone, benzimi ne, benzi pram, benzobicyclon, benzoepin, benzofenap, benzofi uor,

benzohydroxamic acid, benzomate, benzophosphate, benzothiadlazole, benzovindiflupyr, benzoximate, benzoyl prop, benzthiazuron, benzuocaotong, benzyl benzoate,

benzyladenine, berberine, defa~cyf! uthrin _f jbeta-cypermethrin, bethoxazin, BHC, bialaphos, blcyciopyrone, bifenazate, bifenox, bifenthrin, bifujunzhi, biianafos, binapacryi, bi ngqingxiao, bioaliethrin, bioethanomethri n, biopermethri n, bioresmethrin, biphenyi, blsazir, bismerthiazol, bismerthiazoi-copper, bisphenyimercury methylenedi(x- naphthalene-y-sulphonate), bispyri bac, bistrlfi uron, bisultap, bitertanol, bithionol, bixafen, blasticidin-S, borax, Bordeaux mixture, boric acid, boscalid, BPPS, brassl nolide, brassino!ide-ethyl, brevicomi n, brodlfacoum, brofenprox, brofenvalerate, broflaniilde, brofluthrinate, bromacil, bromadiolone, bromchlophos, brometha!in, bromethrin, bromfenvinfos, bromoacetamide, bromobonii, bromobutide, bromociclen, bromocycien, bromo-DDT, bromofenoxi m, bromofos, bromomethane, bromophos, bromophos-ethyl, bromopropylate, bromothaionli, bromoxynil, brompyrazon, bromuconazo!e, bronopol, BRP, BTH, bucarpoiate, bufencarb, bumi nafos, bupi rimate, buprofezin, Burgundy mixture, busulfan, busulphan, butacarb, butach!or, butafenaci i, butam, butamifos, butane-fipronil, butathiofos, butenach!or, butene-fipronii, butethrin, buthidazoie, buthiobate, buthiuron, butifos, butocarboxim, butonate, butopyronoxyl, butoxycarboxim, butralin, butrizoi, butroxydlm, buturon, butylamine, butylate, butyichiorophos, butylene- fipronii, cacody!lc acid, cadusafos, cafenstro!e, caiciferoi, caicium arsenate, calcium chlorate, caicium cyanamide, caicium cyanide, calcium poiysu!fide, caivinphos, cambendichior, campbechior, camphor, captafoi, captan, carbarn, carbamorph, carbanolate, carbaril, carbaryi, carbasulam, carbathion, carbendazim, carbendazol, carbetamide, carbofenotion, carbofuran, carbon disulfide, carbon tetrachloride, carbonyi sulfide, carbophenothion, carbophos, carbosuifan, carboxazole, carboxide, carboxin, carfentrazone, carpropamid, catlap, carvacrol, carvone, CAVP, CDAA, CDEA, CDEC, ceiiocidin, CEPC, ceralure, cerenox, cevadilla, Cheshunt mixture, chinaiphos, chlnaiphos- metby!, chinomethlonat, chinomethionate, chiralaxyl, chitosan, chlobenthiazone, chlomethoxyfen, chloralose, chloramben, chloramine phosphorus, chloramphenicol, chloraniformethan, chloranii, chloranocryl, chiorantraniliprole, chiorazifop, chlorazine, chiorbenside, ch!orbenzuron, chlorbicyclen, chlorbromuron, chlorbufam, chiordane, chiordecone, chlordimeform, chlorempenthrin, chloretazate, chlorethephon,

chiorethoxyfos, chloreturon, chlorfenac, chlorfenapyr, chiorfenazole, chlorfenethol, chiorfenldim, chlorfenprop, chlorfenson, chlorfensulphide, chlorfenvinphos,

chiorfenvinphos-methyi, cbiorfiuazuron, chiorflurazole, chlorflurecol, chlorfiuren, chiorflurenoi, chloridazon, chiorimuron, chlorinate, chlor-IPC, chiormephos, chiormequat, chiormesulone, chlormethoxynll, chlornidine, chlornitrofen, chloroacetic acid,

chlorobenzilate, chlorodinitronaphthalenes, chlorofenizon, chloroform, chloromebuform, chloromethiuron, chioroneb, chlorophacinone, chlorophos, chloroplcrln, chloropon, chloroprallethrin, chloropropylate, chiorothaionil, chloroto!uron, chloroxifenidim,

chloroxuron, chloroxynil, chiorphonium, chiorphoxlm, chlorprazophos, chlorprocarb, chlorpropham, chiorpyrifos, chlorpyrifos-methyl, chlorqulnox, cbiorsuifuron, chlortbai, chlorthiamid, chlorthiophos, chiortoiuron, chiozolinate, chitosan, choiecalciferoi, choline chloride, chromafenozide, cidoheximide, cimectacarb, cimetacarb, cinerin I, cinerln Π, cinerins, cinidon-ethyl, cinmethylin, clnosuifuron, cintofen, ciobutlde, cisaniilde,

cismethrin, clacyfos, ciefoxydim, clenpirin, clenpyrin, c!ethodim, climbazole, ciiodinate, clodinafop, c!oethocarb, ciofencet, clofenotane, clofentezine, clofenvinfos, ciofibric acid, c!ofop, ciomazone, clomeprop, clonitralid, cloprop, c!oproxydlm, ciopyralid, cloquintocet, c!oransuiam, closantel, ciothianidin, clotrimazole, cioxyfonac, cloxylacon, clozylacon, CMA, CMMP, CMP, CMU, codieiure, co!ecaiciferol, colophonate, copper S-qulnolinolate, copper acetate, copper acetoarsenite, copper arsenate, copper carbonate, basic, copper hydroxide, copper naphthenate, copper oieate, copper oxychloride, copper silicate, copper sulfate, copper sulfate, basic, copper zinc chromate, coumachlor, coumafene, coumafos, coumafuryi, coumaphos, coumatetralyl, coumethoxystrobin, coumithoate, coumoxystrobin, CP C, CPMF, CPPC, credazine, cresoi, cresylic acid, crimidine, crotamiton, crotoxyfos, crotoxyphos, crufomate, cryolite, cue-lure, cufraneb, cumyleron, cumyluron, cuprobam, cuprous oxide, curcumenoi, CVMP, cyanamide, cyanatryn, cyanazi ne, cyanofenphos, cyanogen, cyanophos, cyanthoate, cyantraniliprole, cyanuric acid, cyazofamid, cybutryne, cyclafuramid, cyc!aniiide, cycianiiiproie, cycietnri n, cycioate, cyc!oheximide, cycioprate, cycioprothrin, cyclopyrimorate, cyclosulfamuron, cycioxydlm, cyc!uron, cyenopyrafen, cyflufenamid, cyflumetofen, cyfiuthrin, cyhalodiamide, cyhaiofop, cyha!othrin, cyhexati n, cymiazoie, cymoxani i, cyometrinil, cypendazo!e, cypermethrin, cyperquat, cyphenothrin, cyprazine, cyprazole, cyproconazoie, cyprodi nl!, cyprofuram, cypromid, cyprosulfamide, cyromazine, cythioate, cytrex, daimuron, dalapon, daminozide, dayoutong, dazomet, DBCP, of-camphor, DCB, DCIP, DCPA

(Japan), DCPA (USA), DCPTA, DCU, DDD, DDPP, DDT, DDVP, debacarb, decafentin, decamethri n, decarbofuran, deet, dehydroacetic acid, deiquat, delachlor, dei nav, deitamethri n, demephion, demephion-O, demephion-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S-methyl suiphone, demeton-S-methylsulphon, DEP, depa!!ethri ne, derris, desmedi pham, desmetryn, desmetryne, d-fanshiluquebingjuzhi, diafenthiuron, dialifor, diaiifos, dia!iate, di-a!iate, diamidafos, dianat, diatomaceous earth, dlatomlte, diazinon, dibrom, di butyl phthalate, di butyl succinate, dicamba, dlcapthon, dich!obenll , dichlobentiazox, dichlofenthion, dichlofluanid, dichlone, dich!oraiurea, dichiorbenzuron, dichlorfenidim, dichlorflurecol, dichlorflurenoi, dichlormate, dicb!ormid, dichloromethane, dlchiorophen, dichlorprop, dichiorprop-P, dich!orvos, dichlozolin, dichlozollne, diclobutrazol, diclocymet, diclofop, diclomezi ne, dicloran, dicloromezotiaz, dic!osu!am, dicofol, dicophane, dicoumarol, dicresyl, dicrotophos, dicryl, dicumarol, dicyclanil, dicyclonon, dieidrin, dienoch!or, diethamquat, cliethatyl, diethion, diethion, diethofencarb, diethoiate, diethon, diethyl pyrocarbonate, d!etby!toi uamide, difenacoum, difenoconazoie, difenopenten, difenoxuron, difenzoquat, difethiaione, difiovidazin, diflubenzuron, difi ufenican, difi ufenicanii, diflufenzopyr, diflumetorim, dikeguiac, diior, dimatif, dimefiuthrin, dimefox, dimefuron, dimehypo, d!mep!perate, dimetachlone, dimetan, dimethacarb,

dimetbachione, dimethachlor, dimethametryn, dimethenamid, d imethenamid-P, dimethi pin, di methirimol, dimethoate, di methomorph, dimethrin, di methyl carbate, dimethyl disulfide, dimethyl phthalate, dlmetnylvinphos, dimetiian, dimexano, dimidazon, dimoxystrobin, dimpylate, dimuron, dlnex, di ngj unezuo, diniconazoie, diniconazole-M, di nitramine, dinitrophenols, dinobuton, dinocap, dinocap-4, dinocap-6, dinocton, dinofenate, dinopenton, dinoprop, dinosam, dinoseb, dinosuifon, dinotefuran, dinoterb, di noterbon, diofenolan, dioxabenzofos, dioxacarb, dloxathion, dioxation, diphacin, diphacinone, di phenadione, di phenamid, diphenamide, diphenyi suifone, diphenyiamine, dipheny!su!phlde, diprogulic acid, dipropa!in, dipropetryn, dipterex, dipymetitrone, dipyrithione, diquat, dlsodlum tetraborate, disosultap, disparlure, disugran, disul, disulfi ram, disulfoton, ditaii mfos, dithianon, dithicrofos, ditnloether, dithiometon, dithlopyr, dluron, dixanthogen, d-limonene, DM DS, DM PA, DNOC, dodemorph, dodicin, dodine, dofenapyn, doguadlne, domi nlcaiure, doramectln, DPC, drazoxo!on, DSMA, d-trans-allethrin, d-trans-resmethrin, dufuiin, dymron, EBEP, EBP, ebufos, ecdysterone, echlomezol, EDB, EDC, EDDP, edlfenphos, egiinazine, emamecti n, EMPC, empenthrin, enadenine, endosuifan, endothal, endothail, endothion, endri n, enestroburin, enilconazo!e, enoxastrobin, epbirsu!fonate, EPN, epocho!eone,

epofenonane, epoxiconazo!e, eprlnomectin, epronaz, epsilon-metofluthrin, epsi lon- iTiomfiuorothrln, EPTC, erbon, ergocalciferol, erlujlxiancaoan, esdepa!iethrine, esfenvalerate, ESP, esprocarb, etacelasii, etaconazole, etaphos, etem, ethaboxam, ethachlor, ethaifiura!in, ethametsulfuron, ethaprochior, ethephon, ethidimuron, ethiofencarb, ethiolate, ethion, ethiozin, ethiprole, ethiri mol, ethoate- methyl, ethobenzanid, ethofurrtesate, ethohexadiol, ethoprop, etboprophos, ethoxyfen, ethoxyquln, ethoxysulfuron, ethychlozate, ethyl formate, ethyl pyrophosphate, ethylan, ethy!-DDD, ethylene, ethylene dlbromide, ethylene dichloride, ethylene oxide, ethylicin, ethy!mercury 2,3-dihydroxypropyl mercaptide, ethy! mercury acetate, ethylmercury bromide, ethylmercury chloride, ethylmercury phosphate, etinofen, ETM, etnipromid, etobenzanid, etofenprox, etoxazole, etnd!azoie, etrimfos, etrimphos, eugeno!, EXD, famoxadone, famphur, fenac, fenamidone, fenaminosulf, fenaminstrobin, fenami phos, fenapanil, fenarimol, fenasulam, fenazafior, fenazaquin, fenbuconazole, fenbutatin oxide, fenchlorazoie, fench!orphos, fenclofos, fenc!orim, fenethacarb, fenfluthrin, fenfuram, fenhexamid, fenidin, fenitropan, fenitrothion, fenizon, fenjuntong, fenobucarb, fenoiovo, fenoprop, fenothiocarb, fenoxacrim, fenoxanil, fenoxaprop, fenoxaprop-P, fenoxasu!fone, fenoxycarb, fenpicloni!, fenpirithrin, fenpropathrin, fenpropidin, fenpropimorph, fenpyrazami ne, fenpyroxi mate, fenquinotrione, fenridazon, fenson, fensuifothion, fenteracol, fenthiaprop, fenthion, fenthion-ethyl, fentiaprop, fentin, fentrazamide, fentrifanil, fenuron, fenuron-TCA, fenvalerate, ferbam, fenmzone, ferric phosphate, ferrous sulfate, fipronil, f!amprop, flamprop-M, flazasuifuron, flocoumafen, fiometoqu!n, fionicamid, florasulam, fiorpyrauxifen, fi uacrypyrim, fiuazaindo!izine, fluazifop, fluazifop- P, fluazi nam, fluazolate, fluazuron, fl ubendlamlde, flubenzimine, f! ubrocythrinate, fi ucarbazone, f!ucetosuifuron, f!uchiorailn, flucofuron, flucycloxuron, flucythrinate, fi udioxoni!, f!uenethyi, fluenetii, f!uensu!fone, f!ufenacet, f! ufenerlm, fl ufenican, fi ufenoxuron, flufenoxystrobin, flufenprox, fi ufenpyr, fiufenzine, fiuflproie, fiuhexafon, fi umethrin, flumetover, fiumetraii n, flumetsulam, fiumezin, fiu ic!orac, flumioxazin, fl umipropyn, fiumarph, fluometuron, fluopicolide, fluopyram, fl uorbenside, f! uondamid, fl uoroacetamide, fi uoroacetic acid, fluorochlorldone, fiuorodifen, fl uoroglycofen, fl uoroimide, fluoromide, f!uoromidlne, fluoronltrofen, fluoroxypyr, fluothiuron, fl uotrimazole, fiuoxastrobi n, f! upoxam, flupropaci!, flupropadine, fi upropanate, fl upyradifurone, flupyrsulfuron, f! uquinconazoie, fluralaner, f!urazo!e, flurecol, f! urenol, fl uridone, fiuroch!oridone, fluromidine, fiuroxypyr, f!urprimido!, fl ursulamid, flurtamone, fiusi!azole, fiusu!famide, flutenzine, fiuthlacet, fiuthiamide, flutianil, f!utoiani!, f!utriafol, fiuva!inate, fluxametamide, fiuxapyroxad, fiuxofenim, foipel, folpet, fomesafen, fonofos, foramsulfuron, forchlorfenuron, formaldehyde, formetanate, formothion, formparanate, fosamine, fosetyl, fosmethilan, fospirate, fosthiazate, fosthietan, fronta!in, fthaiide, fuberidazole, fucaojing, fucaomi, fujunmanzhi, fulumi, fumarin, funaihecao!ing, fuphenthiourea, furalane, furaiaxy!, furamethrin, furametpyr, furan tebufenozide, furathiocarb, furcarbanil, furconazo!e, furconazole-c/s, furethrin, furfural, furllazole, furmecyclox, furophanate, furyloxyfen, gamma-BHC, gamma-cyhaiothrin, gamma-HCH, genit, gibberei!ic acid, gibbereliin A3, gibberel!ins, giiftor, giitor, g!ucochiora!ose, glufosinate, glufosinate-P, giyodin, giyoxime, giyphosate, glyphoslne, gossypiure, grandiure, grlseofulvin, guanoctine, guazatine, halacrinate, haiauxifen, haifenprox, halofenozide, halosafen, halosulfuron, haloxydine, haloxyfop, haioxyfop-P, haloxyfop-R, HCA, HCB, HCH, hemel, hempa, HEGD, heptachlor, heptafiuthrin, heptenophos, heptopargil, herbimycin, herbimycin A, heterophos, hexachlor, hexachloran,

hexachloroacetone, hexachlorobenzene, hexachlorobutadiene, hexachlorophene, hexaconazoie, hexaflumuron, hexaf!uoramin, hexafl urate, hexalure, hexamlde, hexazinone, hexylthiofos, hexythiazox, HHDN, holosulf, homobrassinolide, huancaiwo, huanchongjing, huangcaoilng, huanjunzuo, hydramethylnon, hydrargaphen, hydrated lime, hydrogen cyanamide, hydrogen cyanide, hydroprene, hydroxyisoxazole, hymexazol, hyquincarb, IAA, IBA, IBP, icaridin, imazalil, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, imibenconazole, imicyafos, imidadoprid, Imidaclothiz, iminoctadine, imiprothrin, inabenfide, indanofan, Indazlfiam, indoxacarb, inezin. Infusorial earth, iodobonii, iodocarb, iodofenphos, iodomethane, iodosulfuron, iofensulfuron, ioxynil, ipazine, IPC, ipconazole, ipfencarbazone,

ipfentrifiuconazole, iprobenfos, iprodlone, iprovalicarb, iprymidam, ipsdienoi, ipsenoi, IPSP, IPX, isamidofos, isazofos, isobenzan, isocarbamid, isocarbamide, isocarbophos, isocil, isodrin, isofenphos, isofenphos-methyl, isofetamid, isolan, isomethiozin,

isonoruron, isopamphos, isopollnate, isoprocarb, isoprocil, isopropalin, isopropazol, isoprothiolane, isoproturon, isopyrazam, jsopyrimoL isothioate, isotianil, isouron, isovaledione, Isoxaben, isoxachlortoie, isoxadifen, isoxaflutole, isoxapyrifop, Isoxathion, isuron, ivermectin, ixoxaben, izopamfos, izopamphos, japonilure, japothrins, jasmoiin I, jasmoiin II, jasmonic acid, jiahuangchongzong, jiajizengxlaolin, jiaxiangjunzhi,

jiecaowan, jiecaoxi, Jinganmycin A, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kadethrin, kappa-bifenthrin, kappa-tefluthrln, karbutliate, karetazan, kasugamydn, kejunlin, kelevan, ketosplradox, kieselguhr, kinetin, kinoprene, kiralaxyl, kresoxim-methyl, kulcaoxi, lactofen, /amdda-cyha!othrin, iancotrione, latiiure, lead arsenate, lenaci!, lepimectin, leptophos, lianbenjingzhi, lime sulfur, lindane, lineatin, llnuron, lirimfos, iitiure, iooplure, lufenuron, lufuqingchongxianan, iuxiancao!in, Ivdingj unzhi, Ivfumijvzhi, !vxiancao!ln, lythidathion, -74, M-81, MAA, magnesium phosphide, malathion, maldison, maleic hydrazide, malonoben, maltodextri n, MAMA, mancopper, mancozeb, mandestrobi n, mandipropamid, maneb, matri ne, mazidox, MCC, MCP, MCPA, MCPA-thioethyi, MCPB, MCPP, mebenii, mecarbam, mecarbinzid, mecarphon, mecoprop, mecoprop-P, medimeform, medi noterb, mediure, mefenacet, mefenoxam, mefenpyr, mefentrifluconazole, mefluidide, megatomoic acid, mel issyl alcohol, melitoxin, MEMC, menazon, MEP, mepanipyrim, meperfluthrin, mephenate, mephosfo!an, mepiquat, mepronil, meptyldinocap, mercaptodimethur, mercaptophos, mercaptophos thiol, mercaptothion, mercuric chloride, mercuric oxide, mercurous chloride, merphos, merphos oxide, mesoprazi ne, mesosuifuron, mesotrlone, mesu!fen, mesulfenfos, mesu!phen, metacresol, metafiumizone, meta!axy!, metaiaxyl-M, metaldehyde, metam, metamifop, metamitron, metaphos, metaxon, metazachior, metazosuifuron, metazoxolon, metconazole, metepa, metflurazon, methabenzthiazuron, methacrifos, methalpropalin, metham, methamidophos, methasulfocarb, methazole, methfuroxam, methibenzuron, methidathion, methiobencarb, methiocarb,

methiopyrisulfuron, ethiotepa, methiozoiin, methi uron, methocrotophos, methoicarb, methometon, methomyl, methoprene, methoprotryn, methoprotryne, methoqui n-buty!, methothrin, methoxychlor, methoxyfenozide, methoxyohenone, methyl aphoiate, methyi bromide, methyl eugenol, methyl iodide, methyl isothiocyanate, methyi parathion, methy!acetophos, methylchloroform, methyldithiocarbamic acid, methyldymron, methylene chloride, methyi-lsofenphos, methy!mercaptophos, methylmercaptophos oxide, methylmercaptophos thiol, methy!mercury benzoate, methy!mercury

dicyandiamide, methyl mercury pentachiorophenoxlde, methylneodecanamide, methylnitrophos, methyitriazothion, metiozolin, metiram, meti ram-zinc, metobenzuron, metobromuron, metofluthrin, metolachlor, metolcarb, metometuron, metominostrobin, metosuiam, metoxadiazone, metoxuron, metrafenone, metrlam, metribuzi n,

metrifonate, metriphonate, metsulfovax, metsulfuron, mevinphos, mexacarbate, mlechuwei, mieshuan, miewenj uzhi, milbemectin, mil bemycin oxime, mi!neb, mi manan, mlpafox, MIPC, mi rex, MNAF, moguchun, molinate, molosuitap, momfluorothrin, monalide, monisuron, monoamitraz, monochloroacetic acid, monocrotophos,

monolinuron, monomehypo, monosuifiram, monosulfuron, monosultap, monuron, monuron-TCA, morfamquat, moroxydine, morphothion, morzid, moxidectin, MPMC, MSMA, MTMC, muscai ure, myciobutanil, myciozolin, myricyl alcohol, /V-(ethyl mercury)-p- toiuenesuiphonaniiide, NAA, NAAm, nabam, naftaiofos, naled, naphthalene,

naphthaleneacetamide, naphthaiic anhydride, naphthalophos, naphthoxyacetic acids, naphthylacetic acids, naphthylindane- l,3-diones, naphthyloxyacetic acids, naproanilide, napropamide, napropamide-M, naptalam, natamyci n, N BPOS, neburea, neburon, nendri n, neonlcotine, nichlorfos, nlciofen, niclosamide, nlcobifen, nlcosuifuron, nicotine, nicotine sulfate, nifluridide, nikkomyclns, NIP, nipyraclofen, nipyralofen, nitenpyram, nithiazine, nitraiin, nitrapyrin, nitriiacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal- isopropyi, nobormide, nonanoi, norbormide, norea, norflurazon, nornicotine, noruron, novaluron, noviflumuron, NPA, nuarimol, nuranone, GCH, octachiorodipropyi ether, octhi!inone, o-dichlorobenzene, ofurace, omethoate, o-phenylphenoi, orbencarb, orfralure, orthobencarb, ortho-dichlorobenzene, orthosulfamuron, oryctaiure,

orysastrobin, oryzaiin, osthoi, osthole, ostramone, ovatron, ovex, oxabetrinil, oxadiargyl, oxadlazon, oxadixyl, oxamate, oxamyi, oxapyrazon, oxapyrazone, oxasulfuron,

oxathlapiprolin, oxazlciomefone, oxine-copper, oxine-Cu, oxollnic acid, oxpoconazoie, oxycarboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyenadenine,

oxyfiuorfen, oxymatrine, oxytetracyciine, oxythloquinox, PAC, paclobutrazol,

paichongding, pallethrine, PAP, para-dichlorobenzene, parafluron, paraquat, parathion, parat ion-methyl, parinol, Paris green, PCNB, PCP, PCP-IMa, p-dichlorobenzene, PD3, pebulate, pedinex, pefurazoate, pelargonic acid, penconazoie, pencycuron,

pendimethalin, penfenate, penflufen, penfiuron, penoxa!in, penoxsu!am,

pentachlorophenol, pentachlorophenyl laurate, pentanoch!or, penthiopyrad, pentmethrin, pentoxazone, perchlordecone, perfluldone, permethrin, pethoxamid, PMC, phenamacril, phenamacril-ethyl, phenaminosuif, phenazine oxide, phenetacarbe, p hen i sop ham, phenkapton, phenmedipham, phenmedipham-ethyl, phenobenzuron, phenothiol, phenothrin, phenproxlde, phenthoate, phenylmercuriurea, phenyl mercury acetate, pheny!mercury chloride, phenyimercury derivative of pyrocatechoi, phenylmercury nitrate, phenylmercury salicylate, phorate, phosacetim, phosalone, phosametine, phosazetim, phosazetin, phoscyclotin, phosdiphen, phosethyl, phosfolan, phosfolan- methyl, phosgiycin, phosmet, phosnichlor, phosphamide, phosphamidon, phosphine, phosphinothricin, phosphocarb, phosphorus, phostin, phoxim, phoxim-methyl, phthaiide, phthaiophos, phthaithrin, picarbutrazox, picaridin, picioram, picoiinafen, picoxystrobin, pimaricin, pindone, pinoxaden, piperalin, piperazine, piperonyl butoxide, piperony! cycionene, plperophos, piproctanly, piproctany!, piprotal, pirimetaphos, pirimicarb, piriminil, plrimloxyphos, pirimiphos-ethyl, plrimlphos-methyl, pival, pivaldione, p!ifenate, PMA, PMP, polybutenes, polycarbamate, poiychiorcamphene, polyethoxyquinollne, polyoxin D, polyoxins, polyoxorim, polythiaian, potassium arsenite, potassium azide, potassium cyanate, potassium ethy!xanthate, potassium naphthenate, potassium polysuifide, potassium thlocyanate, pp'-DDT, prallethrin, precocene I, precocene II, precocene III, pretilachlor, primidophos, primisuifuron, probenazole, prochioraz, proc!onol, procyazine, procymidone, prodiamine, profenofos, profiuazoi, proflura!in, profluthrin, profoxydim, profurite-aminium, progiinazine, prohexadlone,

prohydrojasmon, promacy!, promecarb, prometon, prometryn, prometryne, promurit, pronamide, propachior, propafos, propamidine, propamocarb, propani!, propaphos, propaquizafop, propargite, proparthrin, propazine, propetamphos, propham,

propiconazole, propidine, propineb, propisochlor, propoxur, propoxycarbazone, propyl isome, propyrisulfuron, propyzamide, proquinazid, prosu!er, prosulfalin, prosuifocarb, prosulfuron, prothidathion, prothiocarb, prothloconazole, prothiofos, prothoate,

protrifenbute, proxan, prymidophos, prynachlor, psoralen, psoralene, pydanon,

pydiflumetofen, pyflubumide, pymetrozine, pyracarbolid, pyrac!ofos, pyracloni!,

pyraclostrobin, pyraf!ufen, pyrafluprole, pyramat, pyrametostrobin, pyraoxystrobin, pyrasulfotole, pyraziflumid, pyrazolate, pyrazolynate, pyrazon, pyrazophos,

pyrazosulfuron, pyrazothion, pyrazoxyfen, pyresmethrin, pyrethrln I, pyrethrin II, pyrethrins, pyribambenz-isopropyl, pyribambenz-propyl, pyrlbencarb, pyribenzoxim, pyributicarb, pyricior, pyridaben, pyridafoi, pyridaiyi, pyridaphenthion, pyridaphenthione, pyridate, pyridinitril, pyrifenox, pyrifluquinazon, pyrlftalid, pyrimetaphos, pyrimethanii, pyrimicarbe, pyrirrsidifen, pyriminobac, pyriminostrobin, pyrimiphos-ethyl, pyrimiphos- methy!, pyrimisulfan, pyrimltate, pyrinuron, pyriofenone, pyrlprole, pyripropano!, pyriproxyfen, pyrisoxazoie, pyrithiobac, pyrolan, pyroqulion, pyroxasulfone, pyroxsulam, pyroxych!or, pyroxyfur, qincaosuan, qlngkuiing, quassia, qulnaceto!, quinaiphos, quinalphos-methy!, quinazamid, quinclorac, quinconazole, quinmerac, quinoc!amine, quinofumelin, quinomethionate, quinonamid, qulnothion, quinoxyfen, quintiofos, quintozene, quizaiofop, quizalofop-P, quwenzhi, quyingding, rabenzazoie, rafoxanide, R- diniconazole, rebemide, reglone, renrlduron, resca!ure, resmethrin, rhodethanii,

rhodojaponin-III, ribavirin, rimsulfuron, rlzazoie, R-metaiaxyl, rodethanil, ronnel, rotenone, ryania, sabadilia, saflufenacil, saijunmao, saisentong, salicylanilide, salifluofen, sanguinarine, santonin, S-bloal!ethrln, schradan, sciliiroside, sebuthyiazlne, secbumeton, sedaxane, seiamectin, semiamitraz, sesamex, sesamolin, sesone, sethoxydim, sevin, shuangjiaancaolin, shuangjianancaolln, S-hydroprene, siduron, sifumijvzhi, sigiure, silafluofen, silatrane, silica aerogei, silica gel, silthiofam, silthiopham, silthiophan, silvex, sirrsazine, si rseconazoie, simeton, simetryn, simetryne, sintofen, S-kinoprene, slaked lime, SMA, S-methoprene, S-metolachlor, sodium arsenite, sodium azlde, sodium chlorate, sodium cyanide, sodium fluoride, sodium fluoroacetate, sodium

hexaf!uorosiilcate, sodium naphthenate, sodium o-phenylphenoxlde, sodium

orthophenylphenoxide, sodium pentach!orophenate, sodium pentachlorophenoxide, sodium polysu!fide, sodium sliicofluoride, sodium tetrathlocarbonate, sodium

thiocyanate, solan, sophamide, spinetoram, spinosad, spirodiclofen, spiromesifen, spirotetramat, spiroxamine, stirofos, streptomycin, strychnine, sulcatol, sulcofuron, sulcotrione, sulfallate, sulfentrazone, sulfiram, sulfluramid, sulfodiazole, sulfometuron, sulfosate, sulfosulfuron, sulfotep, suifotepp, su!foxafior, sulfoxide, sulfoxime, sulfur, sulfuric acid, sulfuryl fluoride, suiglycapin, suiphosate, suiprofos, su!tropen, swep, tau- fluvalinate, tavron, tazi carb, TBTO, TBZ, TCA, TCBA, TCMTB, TCIMB, TDE, tebuconazole, tebufenozide, tebufenpyrad, tebufioquin, tebupirimfos, tebutam, tebuthiuron, tecloftalam, tecnazene, tecoram, tedion, tefi ubenzuron, tefluthrin, tefuryltrione, ternbotrione, temefos, temephos, tepa, TEPP, tepraloxydirrt, teproloxydim, terallethrin, terbacil, terbucarb, terbuchlor, terbufos, terbumeton, terbuthylazine, terbutol, terbutryn, terbutryne, terracior, terramici n, terramycin, tetcyclacis, tetrachioroetbane, tetrachlorvi nphos, tetraconazo!e, tetradifon, tetradisul, tetrafiuron, tetramethrin, tetramethy!f!uthrin, tetramine, tetranacti n, tetraniliprole, tetrapion, tetrasui, thallium sulfate, thaiious sulfate, thenyichior, tfteta-cypermethrin,

thiabendazole, thiacloprid, thiadlazine, thiadlfiuor, thiamethoxam, thiameturon, thiapronil, thiazafluron, thiazfluron, thiazone, thiazopyr, thicrofos, thicyofen, thidiazi min, thidiazuron, thiencarbazone, thifensulfuron, thifluzamide, thimerosal, thimet, thiobencarb, thiocarboxi me, thiochlorfenphim, thiochlorphenphime,

thiocyanatodinitrobenzenes, thiocyclam, thiodan, thiodiazole-copper, thiodicarb, thiofanocarb, thiofanox, thlofi uoximate, thiohempa, thiomersal, thiometon, thionazin, thiophanate, thiophanate-ethyl, thiophanate-methyl, thiophos, tbioquinox,

thiosemicarbazide, thiosuitap, thiotepa, thioxamyl, thiram, thluram, thuringiensin, tiabendazole, tiadlnli, tiafenacl i, tiaojiean, TIBA, tifatoi, tiocarbazi!, tioclori m, tioxazafen, tioxymid, tirpate, TMTD, toiciofos-methyl, tolfenpyrad, tolprocarb, tolpyraiate, tolyfluanid, toiyifiuanid, tolylmercury acetate, tomari n, topramezone, toxaphene, TPN, tralkoxydi m, tra!ocythrin, tralomethrin, traiopyrii, transfluthri n, transpermethrin, tretamine, triacontanol, triadimefon, triadimenol, triafamone, trial!ate, tri-allate, triamiphos, triapenthenol, triarathene, triarimoi, triasulfuron, triazamate, triazbutil, triazif!am, triazophos, triazothion, trlazoxide, tribasic copper chloride, tri basic copper sulfate, tribenuron, tribufos, tri buty!ti n oxide, tricamba, trichlamide, trich!opyr, trichlorfon, trichlormetaphos-3, trichloronat, trichioronate, trichiorotrlnitrobenzenes, trichiorphon, triclopyr, triclopyricarb, tricresol, tricyclazoie, tricyclohexyltin hydroxide, tridemorph, trldiphane, trietazl ne, trifenmorph, trifenofos, trifloxystrobin,

trif!oxysulfuron, trifludimoxazin, trifi umezopyrim, triflumizole, triflumuron, trifluralin, triflusulfuron, trifop, trifopsime, trlforine, trlhydroxytriazi ne, trimedlure, tri methacarb, trimeturon, trinexapac, triphenyltin, triprene, tripropindan, triptolide, tritac, trithialan, triticonazole, tritosulfuron, trunc-caii, tuoyeiin, uniconazole, uniconazoie-P, urbacide, uredepa, valerate, vai ldamycln, validamyci n A, vaiifenaiate, valone, vamidothion, vangard, vaniliproie, vemo!ate, vi nciozoli n, vitamin D3, warfarin, xiaochongliulin, xinjunan, xiwojunan, xiwoj unzhi, XMC, xylachlor, xylenols, xylylcarb, xymiazole, yishijing, zarilamid, zeatin, zengxiaoan, zengxiaolin, zefa-cypermethrin, zinc

naphthenate, zinc phosphide, zinc thiazo!e, zi nc thiozoie, zinc trich!orophenate, zinc trichlorophenoxide, zineb, zlram, zolaprofos, zoocoumari n, zoxamide, zuoanj unzhi, zuocaoan, zuojunzhi, zuomihuanglong, α-chlorohydri n, a-ecdysone, a-multistriati n, naphthaieneacetic acids, and β-ecdysone;

(2) the following molecules

(a) V-(3-chloro- l-(pyridin-3-yl)- lH-pyrazol-4-yl)-/V-ethyl-3- ((3,3,3-tnfluoropropyl)thio)propanamide (hereafter "AI- l")

As used in this disclosure, each of the above is an active ingredient. For more information consult the "Compendium of Pesticide Common Names" located at ASanwood.net and various editions, Incl uding the on-line edition, of "The Pesticide Manual" located at bcpcdata.com .

A particularly preferred selection of active ingredients are 1,3-dichloropropene, chlorpyrifos, hexafiumuron, methoxyfenozide, noviflumuron, splnetoram, spi nosad, and suifoxaflor (hereafter "AIGA-2") ,

Additionally, another particularly preferred selection of active ingredients are acequinocyi, acetarrs!prid, acetoprole, avermectin, azinphos-methyl, bifenazate, bifenthri n, carbaryl, carbofuran, chiorfenapyr, chlorfluazuron, chromafenozide,

ciotnianidin, cyfiuthri n, cypernnethrin, deltamethrin, diafenthiuron, emamectin benzoate, endosuifan, esfenvaierate, ethiproie, etoxazoie, fipronil, fionicamid, fluacrypyrim, gamroa-cyha!othrin, haiofenozide, i ndoxacarb, /amftda-cyhalothrin, lufenuron,

malathion, methomyl, novaluron, permethri n, pyridaiy!, pyrimidifen, spirodiciofen, tebufenozide, thiacloprid, thiametnoxam, tniodicarb, toifenpyrad, and zefa-cypermethrin (hereafter "AIGA-3") .

The term "aSkenyS" means an acyclic, unsaturated (at least one carbon-carbon double bond), branched or unbranched, substituent consisti ng of carbon and hydrogen, for example, vinyl, ailyi, butenyl, pentenyl, and hexenyl .

The term "alkenyHoxy" means an alkenyl further consisting of a carbon-oxygen single bond, for example, ally!oxy, butenyloxy, pentenyloxy, hexenyloxy.

The term "alkoxy" means an alkyi further consisting of a carbon-oxygen si ngle bond, for example, methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, and tert- butoxy.

The term "alky!" means an acyclic, saturated, branched or unbranched, substituent consisting of carbon and hydrogen, for example, methyl , ethyl, propyl, isopropyi, butyl, and tert- butyl .

The term "alkynyf" means an acyclic, unsaturated (at least one carbon-carbon triple bond), branched or unbranched, substituent consisting of carbon and hydrogen, for example, ethynyi, propargyi, butynyl, and pentynyl .

The term "aSkynySoxy" means an alkynyi further consisting of a carbon-oxygen single bond, for example, pentynyioxy, hexynyioxy, heptynyloxy, and octynyloxy.

The term "aryf " means a cyclic, aromatic substituent consisting of hydrogen and carbon, for example, phenyl, naphthyl, and bi phenyl .

The term "biopesticide" means a microbial biological pest control agent that, in general, is applied in a si milar manner to chemical pesticides. Commonly they are bacterial, but there are also examples of fungal control agents, incl uding Trichoderma spp. and Ampe!omyces quisqua!is, One well-known blopesticide example is Bacillus species, a bacterial disease of Lepidoptera, Coleoptera, and Diptera . Biopestlcldes incl ude products based on entomopathogenic fungi (e.g. Metarhizium anisopliae), entomopathogenic nematodes (e.g. Steinernema feltiae), and entomopathogenic vi ruses (e.g. Cydia pomoneiia granulovi rus) . Other examples of entomopathogenic organisms incl ude, but are not limited to, bacuiovi ruses, protozoa, and Microsporidia. For the avoidance of doubt, biopestlcldes are active ingredients.

The term "cycloalkenyl" means a monocyclic or polycyciic, unsaturated (at least one carbon-carbon double bond) substituent consisting of carbon and hydrogen, for example, cyclobutenyl, cyclopentenyl, cyc!ohexenyl, norbornenyi, bicyc!o[2.2.2]octenyl, tetrahydronaphthyl, hexahydronaphthyl, and octahydronaphthyl .

The term "cycloalkenyloxy" means a cydoaikenyi further consisting of a carbon-oxygen single bond, for exampie, cyciobutenyioxy, cyclopentenyloxy, norbornenyloxy, and bicyclo[2.2.2]octenyloxy.

The term "cycloalkyl" means a monocyclic or poiycyc! ic, saturated substituent consisti ng of carbon and hydrogen, for example, cyclopropyl, cyclobutyl, cyclopentyl, norbornyi, bicyclo[2.2.2]octyi, and decahydronaphthyl .

The term "cycloaikoxy" means a cycioa! kyi further consisting of a carbon- oxygen single bond, for example, cyclopropyioxy, cyclobutyloxy, cyciopentyioxy, norbornyioxy, and bicyclo[2,2,2]octyloxy.

The term "halo" means fluoro, chloro, bromo, and iodo.

The term "haloalkoxy" means an al koxy further consisting of, from one to the maximum possible number of identical or different, halos, for exampie, fluoromethoxy, trifluoromethoxy, 2,2-difluoropropoxy, chloromethoxy, tricbioromethoxy, 1, 1,2,2- tetraf! uoroethoxy, and pentafluoroethoxy.

The term "haSoa!kyl" means an al kyl further consisti ng of, from one to the maximum possible number of, identical or different, halos, for example, fluoromethyl, trifluoromethyi, 2,2-difluoropropyl, chloromethyl, trichloromethyl, and 1, 1,2,2- tetrafi uoroethyl .

The term "heterocycfyf " means a cyclic substituent that may be aromatic, fully saturated, or partially or fully unsaturated, where the cyclic structure contai ns at least one carbon and at least one heteroatom, where said heteroatom is nitrogen, sulfur, or oxygen, Examples are;

( I) aromatic heterocyclyl substituents include, but are not limited to, benzofuranyl, benzoisothiazolyl, benzoisoxazolyl, benzothienyl, benzothiazoiyi, benzQxazoiyl, cinnoli nyi, furanyl, imidazolyi, i ndazolyi, indolyl, isoindolyi, isoquinolinyl, isothiazoiyi, Isoxazoiyl, oxadiazoiy!, oxazolinyi, oxazo!yl, phthalazi nyl, pyrazinyl, pyrazoli nyl, pyrazo!yl, pyridazinyi, pyridyl, pyrimidinyi, pyrroiyi, qui nazoilny!, quinoiinyl, quinoxali nyl, tetrazolyl, thlazolinyi, thlazo!yl, thlenyl, triazlnyl, and trlazo!yi;

(2) fully saturated heterocyc!yf substituents incl ude, but are not limited to, piperazinyl, pi peridinyl, morpho! inyl, pyrrolidinyl, tetrahydrofuranyl, and

tetrahydropyranyl ;

(3) partially or fully unsaturated heterocycfyf substituents i nclude, but are not l imited to, 4,5-dihydro- isoxazolyl, 4,5-dihydro-oxazolyl, 4,5-dihydro- l - - pyrazoiyl, 2,3-dihydro-[l,3,4]-oxadiazolyl, and 1,2,3,4-tetrahydro-quinolinyl ; and

(4) Additional examples of heterocydyis Incl ude the followi ng ;

thietany! thietany!-oxide and thietanyi-dioxide.

The term "focus" means a habitat, breedi ng ground, plant, seed, soil, material, or environment, in which a pest Is growing, may grow, or may traverse. For example, a locus may be: where crops, trees, fruits, cereals, fodder species, vines, turf, and/or ornamental plants, are growing ; where domesticated animals are residing; the interior or exterior surfaces of buildi ngs (such as places where grai ns are stored) ; the materials of construction used in buildings (such as i mpregnated wood) ; and the soil around buildi ngs,

The phrase "MoA Materia!" means an active ingredient having a mode of action

("Mo A") as indicated in IRAC MoA Classification v. 7,4, located at irac-Oniine.org ,, which descri bes the following groups.

( 1) Acetylcholinesterase (ACHE) inhibitors, includes the fol lowi ng active ingredients acephate, alanycarb, aidicarb, azamethlphos, azlnphos-ethyi, azi nphos- methyl, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, cadusafos, carbaryl, carbofuran, carbosulfan, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl, diazinon,

dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EP!M, ethiofencarb, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenobucarb, fenthion, formetanate, fosthiazate, furathiocarb, heptenophos, i micyafos, Isofenphos, isoprocarb, isopropyi 0-(methoxyaminothio-phosphoryl)salicylate, Isoxathion, maiathion, mecarbam, methamidophos, methidathion, methiocarb, methomyl, metolcarb, mevinphos, monocrotophos, Naled, omethoate, oxamyl, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxi m, piri micarb, pirimiphos-methyl, profenofos, propetamphos, propoxur, prothiofos, pyraclofos, pyridaphenthion, qui nal phos, suifotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thlodlcarb. thlofanox, thiometon, triazamate, triazophos, trlchlorfon, trimethacarb, vamidothion, XMC, and xylyicarb,

ί 2 ) GABA-gated chioride channel antagonists, Includes the following active ingredients chlordane, endosuifan, ethiproie, and fipronii ,

(3) Sodium channel modulators, i ncludes the following active ingredients acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl, bioresmethri n, cycioprothri n, cyfiuthrin, 0efa--cyf!uthrln, cyhalothrin, /amii -cyhalothrin, gamma-cyha!othri n, cypermethrin, alpha- cypermethrin, 6eta-cypermethri n, ffteta-cypermethrin, zefa-cypermethrin, cyphenothrin [( l/?)-irans-isomers], deltamethrin, empenthrin [(£Z)-(l/?)-isomers], esfenvaierate, etofenprox, fenpropathrin, fenvalerate, fiucythrinate, fiumethrin, tau-fluvalinate, halfenprox, i mi prothrin, kadethrin, permethrin, phenothri n [( l/?)-frans-isomer], praliethrin, pyrethrins (pyrethrum), resmethrin, silafluofen, tefluthri n,

tetramethrin, tetramethrin [( l ?)-isomers], tralomethri n, and transf!uthri n, and methoxychior.

(4) Nicotinic acetylcholine receptor (nACH ) agonists, includes the foiiowing active i ngredients

(4A) acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacioprid, thiamethoxam,

(4B) nicotine,

(4C) su!foxaflor,

(40) flupyradifurone,

(4E) trifl umezopyrim and dicioromezotiaz.

(5) Nicotinic acetyicho!ine receptor (nACh ) a!losteric activators, incl udes the foi iowing active i ngredients spinetoram and spinosad ,

(6) Chloride channel activators, includes the foiiowi ng active Ingredients abamectin, emamectin benzoate, !epimectin, and milbemecti n.

(7) Juvenile hormone mimics, i ncludes the following active ingredients hydroprene, kinoprene, methoprene, fenoxycarb, and pyrlproxyfen ,

(8) Miscellaneous nonspecific (multi-site) inhibitors, Includes the following active i ngredients methyl bromide, chloropicrin, suifuryl fluoride, borax, boric acid, disodlum octaborate, sodium borate, sodium metaborate, tartar emetic, diazomet, and metam.

(9) Modulators of Chordotonal Organs, includes the following active ingredients pymetrozine and flonicamid .

( 10) Mite growth inhibitors, includes the following active ingredients c!ofentezi ne, exythiazox, diflovidazin, and etoxazole.

( 11) Microbial disrupters of insect midgut membranes, i ncludes the following active I ngredients Bacillus thuringiensis subsp. israelensis. Bacillus

thuringiensis subsp. aizawai, Bacillus thuringiensis subsp, kurstaki, Bacillus thuringiensis subsp, tenebrionenis, Bt crop proteins (CrylAb, CrylAc, CrylFa, CrylA, 105, Cry2Ab, Vl p3A, mCrySA, CryBAb, CrySBb, Cry34Abl/Cry35Ab l), and Bacillus sphaericus.

( 12) Inhibitors of mitochondrial ATP synthase, includes the following active Ingredients tetradlfon, propargite, azocyclotin, cyhexatin, fenbutatin oxide, and diafenthi uron, ( 13) Uncoupiers of oxidative phosphorylation via disruption of the proton gradient, includes the following active ingredients chiorfenapyr, DNOC, and suif!uramid ,

( 14) Nicotinic acetylcholine receptor (nAChR) channel blockers, includes the following active ingredients bensultap, cartap hydrochloride, th!ocyc!am, and thiosultap-sodium.

( 15) Inhibitors of chitin biosynthesis, type 0, Includes the following active ingredients bistrifiuron, chlorfiuazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, noval uron, noviflumuron, teflubenzuron, and triflumuron , ( 16) Inhibitors of chitin biosynthesis, type 1, Includes the following active ingredient buprofezin.

( 17) moulting disrupter, Dipteran, includes the following active ingredient cyromazi ne.

( IS) Ecdysone receptor agonists, includes the fol lowing active Ingredients chromafenozide, ha!ofenozide, methoxyfenozide, and tebufenozide.

( 19) Gctopamine receptor agonists, incl udes the following active Ingredient amitraz.

(20) Mitochondrial complex III electron transport inhibitors, includes the following active i ngredients hydra methyl non, acequlnocyi, and fluacrypyrim .

(21) itochondrial complex I electron transport inhibitors, Includes the following active ingredients fenazaquln, fen pyroxi mate, pyrlmidifen, pyridaben, tebufenpyrad, toifenpyrad, and rotenone.

(22) Voltage-dependent sodium channel blockers, Includes the following active Ingredients indoxacarb and metaflumizone.

(23) Inhibitors of acetyl CoA carboxylase, includes the fol lowing active ingredients spi odiclofen, spiromesifen, and spi otetramat,

(24) mitochondrial complex IV electron transport inhibitors, includes the following active I ngredients, ai umi nium phosphide, calcium phosphide, phosphlne, zinc phosphide, and cyanide,

(25) Mitochondria! complex II electron transport inhibitors, includes the following active I ngredients cyenopyrafen, cyfiumetofen, and pyfiubumide, and

(28) Ryanodine receptor modulators, i ncludes the following active ingredients chlorantraniiiproie, cyantraniliprole, and flubendiamide.

Groups 26 and 27 are unassigned In this version of the classification scheme. Additionally, there is a Group UN that contai ns active ingredients of unknown or uncertain mode of action. This group includes the followi ng active ingredients, azadirachtin, benzoximate, Difenazate, Dromopropylate, cninomethionat, cryolite, dicofoi, pyridalyl, and pyrifluquinazon. The term "pest" means an organism that Is detri mental to humans, or human concerns (such as, crops, food, l ivestock, etc.), where said organism is from Phyla Arthropoda, Mol lusca, or Nematoda . Particular examples are ants, aphids, bed bugs, beetles, bristletails, caterpillars, cockroaches, crickets, earwigs, fleas, flies,

grasshoppers, grubs, hornets, jassids, leafhoppers, lice, locusts, maggots, mealybugs, mites, moths, nematodes, plantbugs, planthoppers, psyi lids, sawf! ies, scales, sllverfish, slugs, snails, spiders, springtails, stink bugs, symphyians, termites, thrips, ticks, wasps, whitef!les, and wireworms.

Additional examples are pests in

( I) Subphyta Chelicerata, Mynapoda, and Hexapoda .

(2) Classes of Arachnida, Symphyfa, and Insecta ,

(3) Order AnopSura . A non-exhaustive list of particular genera includes, but is not limited to, Haematopinus spp. , Hoplopleura spp., Linognathus spp., Pediculus spp. , Polyplax spp., So!enopotes spp., and Neohaematopinis spp. A non-exhaustive list of particular species includes, but is not limited to, Haematopinus asini, Haematopinus suis, Linognathus setosus, Linognathus ovillus, Pediculus humanus capitis, Pediculus humanus humanus, and Pthirus pubis.

(4) Order Co!eoptera, A non-exhaustive list of particular genera includes, but is not limited to, Acanthoscelides spp., Agriotes spp. , Anthonomus spp. , Apion spp., Apogonia spp. , Araecerus spp. , Aulacophora spp. , Bruchus spp, , Cerosterna spp.,

Cerotoma spp. , Ceutorhynchus spp. , Chaetocnema spp., Coiaspis spp., Ctenicera spp., Curculio spp., Cyciocephala spp., Diabrotica spp., Dinoderus spp. , Gnathocerus spp., Hemicoelus spp. , Heterobostruchus spp. , Hypera spp., Ips spp. , Lyctus spp,, Megascelis spp,, Me!igethes spp,, Mezium spp, , Niptus spp. , Otiorhynchus spp,, Pantomorus spp,, Phyilophaga spp., Phyllotreta spp., Ptinus spp. , Rhizotrogus spp., Rhynchites spp. ,

Rhynchophorus spp. , Scolytus spp, , Sphenophorus spp,, Sitophilus spp., Tenebrio spp,, and T bolium spp. A non-exhaustive list of particular species includes, but Is not limited to, Acanthoscelides obtectus, Agrilus pianipennis, Ahasverus advena, Alphitobius diaperinus, Anopiophora glabripennis, Anthonomus grandis, Anthrenus verbasci, Anthrenus falvipes. Ataenius spretulus, Atomaria linearis, Attagenus unicolor.

Bothynoderes punctiventris, Bruchus pisorum, Callosobruchus maculatus, Carpophilus hemipterus, Cassida vittata, Cathartus quadricol!is, Cerotoma trifurcata, Ceutorhynchus assimilis, Ceutorhynchus napi, Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar, Cotinis nitida, Crioceris asparagi, Crypto!estes ferrugineus, Cryptolestes pusillus, Cryptolestes turcicus, Cylindrocopturus adspersus, Deporaus marginatus, Dermestes lardarius, Dermestes maculatus, Epiiachna varivestis, Euvrilletta peltata, Faustinus cubae, Hy!obius pales, Hy!otrupes bajulus, Hypera postica, Hypothenemus hampei, Lasioderma serricorne, Leptinotarsa decemlineata, Limonius canus, Liogenys fuscus, Liogenys suturalis, Lissorhoptrus oryzophi!us, Lophocateres pusi!!us, Lyctus planicoHis, Maecolaspis joliveti, Me!anotus communis, Meligethes aeneus, Melolontha me!o!ontha, Necrohia rufipes, Oberea brevis, Oberea linearis, Oryctes rhinoceros, Qryzaephi!us mercator, Oryzaephiius surinamensis, Ouiema meianopus, Ouiema oryzae, Phyiiophaga cuyabana, Poiycaon stoutti, Popi!iia japonica, Prostephanus truncatus,

Rhyzopertha dominica, Sitona lineatus, Sitophilus grana us, Sitophiius oryzae, Sitophiius zeamais, Stegobium paniceum, Tenebroides mauritanicus, Triho!ium castaneum, Tribolium confusum, Trogoderma granarium, Trogoderma variabiie, Xestobium rufoviilosum, and Zabrus tenebrioides,

(5) Order Dermaptera . A non-exhaustive list of particular species includes, but is not iimited to, Forficula auricularia .

(6) Order Blattaria, A non -exhaustive iist of particular species includes, but is not limited to, Blattel!a gerrnanica, Biatteila asahinai, Biatta orientaiis, Biatta lateralis, Parcoblatta pennsyivanica, Periplaneta americana, Periplaneta austraiasiae, Periplaneta brunnea, Periplaneta fuliginosa, Pycnoscelus surinamensis, and Supella longipalpa.

17) Order Diptera. A non-exhaustive list of particular genera includes, but is not limited to, Aedes spp. , Agromyza spp., Anastrepha spp.. Anopheles spp., Bactrocera spp., Ceratitis spp. , Chrysops spp., Cochliomyia spp,, Contarinia spp,, Culex spp., Culicoides spp,, Dasineura spp,, Delia spp, , Drosophila spp., Fannia spp., Hylemya spp., Liriornyza spp, , Musca spp., Phorbia spp., Pollenia spp. , Psychoda spp. , Sirnulium spp. , Tabanus spp., and Tipula spp. A non-exhaustive list of particular species includes, but is not Iimited to, Agromyza fronteila, Anastrepha suspense, Anastrepha iudens, Anastrepha obliqua, Bactrocera cucurbitae, Bactrocera dorsalis, Bactrocera invadens, Bactrocera zonata, Ceratitis capitata, Dasineura brassicae, Delia platura, Fannia canicularis, Fannia scalaris, Gasterophiius intestinaiis, Gracillia perseae, Haematobia irritans, Hypoderma iineatum, Liriornyza brassicae, Liriornyza sativa, Melophagus ovinus, Musca autumnalis, Musca dornestica, Oestrus ovis, Oscinella frit, Pegomya betae, Piophiia casei, Psila rosae, Rhagoletis cerasi, Rhagoletis pomoneiia, Rhagoietis mendax, Sitodipiosis moseliana, and Stomoxys calcitrans,

(8) Order Hemiptera . A non-exhaustive iist of particular genera Includes, but Is not iimited to, Adeiges spp., Auiacaspis spp,, Aphrophora spp,, Aphis spp,, Bemisia spp., Ceroplastes spp, , Chionaspis spp,, Chrysomphalus spp.. Coccus spp., E poasca spp., Euschistus spp,, Lepidosaphes spp., Lagynotomus spp., Lygus spp., Macrosiphum spp., Nephotettix spp, , Nezara spp. , Nilaparvata spp., Philaenus spp., Phytocoris spp. , Piezodorus spp, , Planococcus spp., Pseudococcus spp., Rhopalosiphum spp., Saissetia spp., Therioaphis spp. , Toumeyeiia spp. , Toxoptera spp., Trialeurodes spp. , Triatoma spp,, and Unaspis spp. A non-exhaustive list of particular species incl udes, but is not li mited to, Acrosternum hilare, Acyrthosiphon pisum, Aleyrodes proletella, Aleurodicus dispersus, A!eurothrixus f!occosus, Amrasca biguttula biguttuia, Aonidieila aurantii, Aphis fabae, Aphis gossypii, Aphis glycines, Aphis poms ^' , Au!acorthum so!ani, Bactericera cockerelii, Bagrada hiiaris, Bemisia argentifoiii, Bemisia tabaci, Blissus leucopterus, Boisea trivittata, Brachycorynelia asparagi, Brevennia rehi, Brevicoryne brassicae, Cacopsyila pyri, Cacopsy!ia pyricola, Caiocoris norvegicus, Ceropiastes rubens, Cimex hemipterus, Cimex iectularius, Coccus pseudomagnoliarum, Dagbertus fasciatus, Dicheiops furcatus, Diuraphis noxia, Diaphorina citri, Dysaphis plantaginea, Dysdercus suturellus, Edessa meditabunda, Empoasca vitis, Eriosoma lanigerum, Erythroneura elegantula, Eurygaster maura, Euschistus conspersus, Euschistus heros, Euschistus servus, Halyomorpha haiys, He!opeltis antonii, Hyaiopterus pruni, Heiopeitis antonii, Helopeitis theivora, Icerya purchasi, Idioscopus nitiduius, Jacobiasca formosana, Laodelphax striatellus, Lecaniurn corni, Leptocorisa oratorius, Leptocorisa varicornis, Lygus hesperus, Maconeiiicoccus hirsutus, Macrosiphum euphorbiae, Macrosiphum granarium, Macrosiphum rosae, Macroste!es quadriiineatus, Mahanarva frimbio!ata, Megacopta cribraria, Metopoiophium dirhodum, Mictis iongicornis, Myzus persicae,

Nasonovia ribisnigri, Nephotettix cincticeps, Neurocoipus iongirostris, Nezara viridu!a, NUaparvata lugens, Paracoccus marginatus, Paratrioza cockerelii, Parlatoria perqandii, Pariatoria ziziphi, Peregrinus aidis, Phylloxera vitifoliae, Physokermes piceae,

Phytocoris caiifornicus, Phytocoris relativus, Piezodorus guildinii, Planococcus citri, Planococcus ficus, Poecilocapsus iineatus, Psallus vaccinicola, Pseudacysta perseae, Pseudococcus brevipes, Quadraspidiotus perniciosus, Rhopalosiphum maidis,

Rhopaiosiphum pads, Saissetia o!eae, Scaptocoris castanea, Schizaphis graminum, Sitobion avenae, Sogatella furcifera, Tria!eurodes vaporariorum, Trialeurodes

abutiloneus, Unaspis yanonensis, and Zu!ia entrerriana.

(9) Order Hymenoptera, A non-exhaustive list of particular genera includes, but is not limited to, Acromyrmex spp. , Atta spp. , Camponotus spp., Diprion spp.,

Dolichovespuia spp. , Formica spp,, Monomorium spp,, Neodiprion spp., Paratrechina spp, , Pheidole spp. , Pogonomyrmex spp., Polistes spp., Solenopsis spp., Technomyrmex, spp. , Tetramorium spp. , Vespula spp., Vespa spp. , and Xyiocopa spp. A non-exhaustive list of particular species incl udes, but Is not limited to, Athalia rosae, Atta texana, Caliroa cerasi, Cimbex americana, Iridomyrmex humi!is, Linepithema humile, Mellifera

Scuteilata, Monomorium minimum, Monomorium pharaonis, Neodiprion sertifer,

Solenopsis invicta, Solenopsis geminata, Solenopsis molesta, Solenopsis richtery, Solenopsis xyloni, Tapinoma sessile, and Wasmannia auropunctata.

( 10) Order Isoptera. A non-exhaustive list of particular genera i ncludes, but is not limited to, Coptoterrnes spp., Cornitermes spp, , Cryptoterrnes spp. , Heterotermes spp., Kalotermes spp., Incisitermes spp., Macrotermes spp. , Marginitermes spp., Microcerotermes spp., Procornitermes spp. , Reticulitermes spp., Schedorhinotermes spp., and Zootermopsis spp. A non-exhaustive list of particular species includes, but is not limited to, Coptotermes acinaciformis, Coptotermes curvignathus, Coptotermes frenchi, Coptotermes formosanus, Coptotermes gestroi, Cryptotermes brevis,

Heterotermes aureus, Heterotermes tenuis, Incisitermes minor, Incisitermes snyderi, Microtermes obesi, Nasutitermes corniger, Odontotermes formosanus, Odontotermes obesus, Reticulitermes banyuiensis, Reticulitermes grassei, Reticulitermes flavipes, Reticuliiermes hageni, Reticulitermes hesperus, Reticulitermes santonensis,

Reticulitermes speratus, Reticulitermes tibialis, and Reticulitermes virginicus,

( 11) Order Lepidoptera. A non-exhaustive list of particular genera Includes, but is not limited to, Adoxophyes spp. , Agrotis spp., Argyrotaenia spp. , Cacoecia spp,, Caloptiiia spp, , Chilo spp,, Chrysodeixis spp,, Coiias spp,, Crambus spp., Diaphania spp,, Diatraea spp. , Earias spp., Ephestia spp, , Epimecis spp,, Feltia spp,, Gortyna spp. , Helicoverpa spp., Heiiothis spp., Indarbela spp. , Lithocoiletis spp., Loxagrotis spp., Malacosoma spp. , Nemapogon spp. , Peridroma spp., Phylionorycter spp., Pseudaletia spp., Plutella spp., Sesamia spp., Spodoptera spp., Synanthedon spp., and Yponomeuta spp. A non-exhaustive list of particular species Includes, but is not limited to, Achaea Janata, Adoxophyes orana, Agrotis ipsilon, Alabama argillacea, Amorbia cuneana, Amyeiois transiteiia, Anacamptodes defectaria, Anarsia iineatella, Anomis sabulifera, Anticarsia gemmatalis, Archips argyrospiia, Archips rosana, Argyrotaenia citrana, Autographa gamma, Bonagota cranaodes, Borbo cinnara, Bucculatrix thurberielia, Capua reticu!ana, Carposina niponensis, Chlumetia transversa, Choristoneura rosaceana, Cnaphaiocrocis medinalis, Conopo orpha cramerella, Corcyra cephalonica , Cossus cossus, Cydia caryana, Cydia funebrana, Cydia molesta, Cydia nigricana, Cydia po onella, Darna diducta, Diaphania nitida!is, Diatraea saccharalis, Diatraea

grandiosella , Earias insulana, Earias vittei!a, Ecdytolopha aurantianum, Elasmopa!pus iignosellus, Ephestia cautella, Ephestia elutella, Ephestia kuehniella, Epinotia aporema, Epiphyas postvittana, Erionota thrax, Estigmene acrea, Eupoeciiia ambiguella, Euxoa auxiliaris, Galleria meiloneila, Graphoiita molesta, Hedylepta indicata, Helicoverpa armigera, Helicoverpa zea, Heiiothis virescens, Hei!ula undaiis, Keiferia lycopersice!la, Leucinodes orbonalis, Leucoptera coffeella, Leucoptera maiifoiieila , Lobesia botrana,

Loxagrotis albicosta, Lymantria dispar, Lyonetia c!erkella, Mahasena corbetti, Mamestra brassicae, Manduca sexta, Maruca testulaiis, Metisa plana, Mythi na unipuncta,

Neoieucinodes eieganta!is, Nymphula depunctalis, Gperophtera bru ata, Gstrinia nubilaiis, Oxydia vesulia, Pandemis cerasana, Pande is heparana, Papilio demodocus, Pectinophora gossypieila, Peridroma saucia, Perileucoptera coffeella, Phthorimaea operculella, Phyilocnistis citreiia, Phylionorycter blancardella, Pieris rapae, Plathypena scabra, Piatynota idaeusalis, Plodia interpunctella, Plutella xyiosteila, Poiychrosis viteana, Prays endocarpa, Prays oieae, Pseudaletia unipuncta, Pseudoplusia includens, Rachiplusia nu, Scirpophaga incertulas, Sesamia inferens, Sesamia nonagrioides, Setora nitens, Sitotroga cerea!ella, Sparganothis pil!eriana, Spodoptera exigua, Spodoptera frugiperda, Spodoptera eridania, Thec!a basiiides, Tinea pe!iione!ia, Tineola bisse!liella , Trichop!usia ni, Tuta abso!uta, Zeuzera coffeae, and Zeuzea pyrina.

( 12) Order Ma ophaga . A non-exhaustive iist of particular genera includes, but is not limited to, Anaticola spp. , Bovicola spp., Cheiopistes spp., Goniodes spp. , Menacanthus spp. , and Trichodectes spp. A non-exhaustive iist of particular species incl udes, but Is not limited to, Bovicola bovis, Bovicola caprae, Bovicola ovis, Cheiopistes meleagridis, Goniodes dissimilis, Goniodes gigas, Menacanthus stramineus, Menopon gailinae, and Trichodectes canis,

( 13) Order Orthoptera, A non-exhaustive iist of particular genera Incl udes, but Is not limited to, Melanoplus spp. and Pterophylla spp. A non-exhaustive list of particular species includes, but is not li mited to, Acheta domesticus, Anabrus simplex, Gryllota!pa africana, Gryllotalpa australis, Gryiiotalpa brachyptera, Gryliotalpa

hexadactyia , Locusta migratoria, Microcentrum retinerve, Schistocerca gregaria, and Scudderia furcata,

( 14) Order Psocoptera . A non-exhaustive list of particular species includes, but Is not limited to, Liposcelis decolor, Liposcelis entomophila, Lachesilla quercus, and Trogium pulsatorium,

( IS) Order Ssphonaptera. A non-exhaustive list of particular species includes, but is not limited to, CeratophyUus gailinae, CeratophyUus niger, Ctenocephalides canis, Ctenocephalides fells, and Pulex irritans.

( 16) Order Thysanoptera. A non-exhaustive i ist of particular genera i ncludes, but Is not limited to, Caliothrips spp., Frankliniel!a spp. , Scirtothrips spp., and Thrips spp. A non-exhaustive list of particular species incl udes, but is not limited to, Caliothrips phaseoii, Frankliniella bispinosa, Frankliniella fusca, Frank!inie!la occidentalis,

Frank!inie!la schuitzei, Frankliniella tritici, Frankliniella wiiliamsi, Heliothrips

haemorrhoidalis, Rhipiphorothrips cruentatus, Scirtothrips citri, Scirtothrips dorsalis, Taeniothrips rhopaiantennalis, Thrips hawaiiensis, Thrips nigropilosus, Thrips orientaiis, Thrips palmi, and Thrips tabaci,

( 17) Order Thysanura. A non-exhaustive iist of particular genera includes, but Is not limited to, Lepisma spp. and Thermobia spp.

( 18) Order Acarina. A non-exhaustive iist of particular genera Includes, but is not limited to, Acarus spp., Aculops spp,, Argus spp., Boophilus spp,, Demodex spp,, Dermacentor spp., Epitrimerus spp, , Eriophyes spp., Ixodes spp., Oligonychus spp., Panonychus spp., Rhizoglyphus spp,, and Tetranychus spp. A non-exhaustive list of particular species includes, but is not li mited to, Acarapis woodi, Acarus siro, Aceria mangiferae, Aculops !ycopersici, Aculus pelekassi, Acu!us schlechtendali, Amb!yomma americanum, Brevipaipus ohovatus, Brevlpa!pus phoenlds, Dermacentor variabilis, Dermatophagoides pteronyssinus, Eotetranychus carpini, Liponyssoides sanguineus, Notoedres cati, Gligonychus coffeae, Oiigonychus ilicis, Ornithonyssus bacoti,

Panonychus citri, Panonychus uimi, Phyllocoptruta oleivora, Poiyphagotarsonemus latus, Rhipicephalus sanguineus, Sarcoptes scabiei, Tegolophus perseaflorae, Tetranychus urticae, Tyrophagus longior, and Varroa destructor.

( 19) Order Araneae, A non-exhaustive l ist of particular genera Includes, but is not limited to, Loxosceles spp. , Latrodectus spp., and Atrax spp. A non-exhaustive list of particular species includes, but is not li mited to, Loxosceles reclusa, Latrodectus mactans, and Atrax robustus.

(20) Class SymphyHa. A non-exhaustive list of particular species I ncludes, but is not limited to, Scutigerella immaculate.

(21) Subclass CoS emboia , A non-exhaustive l ist of particular species incl udes, but Is not limited to, Bourletiella hortensis, Onychiurus armatus, Onychiurus fimetarius, and Sminthurus viridis.

(22) Phylum ematoda. A non-exhaustive list of particular genera includes, but Is not limited to, Aphe!enchoides spp. , Belonolaimus spp., Criconeme!la spp., Ditylenchus spp., Globodera spp. , Heterodera spp., Hirschmannielia spp., Hoplolai us spp., Meioidogyne spp, , Pratylenchus spp., and Radopholus spp. A non-exhaustive list of particular species includes, but is not limited to, Dirofiiaria immitis, Globodera pallida, Heterodera glycines, Heterodera zeae, Meioidogyne incognita, Meioidogyne javanica, Onchocerca volvulus, Pratylenchus penetrans, Radopholus simiiis, a d Rotyienchuius reniformis.

(23) Phylum MofSusc . A non-exhaustive list of particular species Includes, but is not limited to, Arion vulgaris, Cornu aspersum, Deroceras reticulatum, Limax fiavus, Milax gagates, and Pomacea canaliculate.

A particularly preferred pest group to control is sap-feeding pests. Sap-feeding pests, in general, have piercing and/or sucking mouthparts and feed on the sap and inner plant tissues of plants. Examples of sap-feeding pests of particular concern to agriculture include, but are not limited to, aphlds, ieafhoppers, moths, scales, thri ps, psy!lids, mealybugs, stinkbugs, and whltefiies. Specific examples of Orders that have sap-feedi ng pests of concern in agriculture i nclude but are not limited to, Anopiura and Hemiptera . Specific exampies of Hemiptera that are of concern in agriculture include, but are not l imited to, Aulacaspis spp,, Aphrophora spp., Aphis spp., Bemisia spp., Coccus spp., Euschistus spp., Lygus spp., Macrosiphum spp., Nezara spp. , and Rhopalosiphum spp.

Another particularly preferred pest group to control is chewi ng pests. Chewing pests, in general, have mouthparts that allow them to chew on the plant tissue including roots, stems, leaves, buds, and reproductive tissues (incl udi ng, but not limited to flowers, fruit, and seeds) . Examples of chewing pests of particular concern to agriculture inci ude, but are not limited to, caterpillars, beetles, grasshoppers, and locusts. Specific examples of Orders that have chewing pests of concern in agriculture i ncl ude but are not li mited to, Coieoptera and Lepidoptera . Specific examples of Coleoptera that are of concern in agriculture Include, but are not limited to, Anthonomus spp., Cerotoma spp., Chaetocnema spp., Coiaspis spp., Cydocephala spp. , Diabrotica spp., Hypera spp., Phy!!ophaga spp., Phy!!otreta spp., Sphenophorus spp., Sitophi!us spp.

The phrase "pesticida!ly effective amount" means the amount of a pesticide needed to achieve an observable effect on a pest, for example, the effects of necrosis, death, retardation, prevention, removal, destruction, or otherwise di minishing the occurrence and/or activity of a pest in a locus. This effect may come about when pest populations are repulsed from a locus, pests are I ncapacitated in, or around, a locus, and/or pests are exterminated in, or around, a locus. Of course, a combination of these effects can occur. Generally, pest populations, activity, or both are desirably reduced more than fifty percent, preferably more than 90 percent, and most preferably more than 99 percent, In general, a pesticidaiiy effective amount, for agricultural purposes, is from about 0.0001 grams per hectare to about 5000 grams per hectare, preferably from about 0,0001 grams per hectare to about 500 grams per hectare, and it is even more preferably from about 0, 0001 grams per hectare to about 50 grams per hectare.

Detailed description of this disclosure

This document di

wherein :

(A) R ¹ Is selected from the group consisti ng of H, F, CI, Br, I, CN, NOz, SF- and (Ci ~C3)haloaikyi ;

(B) R ² Is selected from the group consisti ng of H, F, CI, Br, I, CN, NOz, SF and (Ci-C3)haloalkyi ;

(C) R ³ is selected from the group consisting of H, F, CI, Br, I, CN , NOz, SF and (Ci-C3)haloalkyl ; (D) R ⁴ is selected from the group consisting of H, F, CI, Br, I, CN, NOz, SF5, and (Ci~C3)ha!oalkyi;

(E) R ⁵ is selected from the group consisting of H, F, CI, Br, I, CN, NOz, SF5, and (Ci-C3)haloalkyi;

(F) R ⁶ is H;

(G) R ⁷ is selected from the group consisting of F, CI, and Br;

(H) R ⁸ is selected from the group consisting of F, CI, and Br;

(I) R ⁹ is H;

(J) Q ¹ Is selected from the group consisting of 0 and S;

(iC) Q ² is selected from the group consisting of 0 and S;

(L) R ¹⁰ is selected from the group consisting of H, (C1-C3) aikyl, (C2-

C ₃ )alkenyl, {C2-C ₃ )aikynyi, (Ci-C3)alkylO(Ci-C3)alkyl, and (Ci-C3)alkylOC(=0)(Ci-

C3)alkyl;

(M) R ¹¹ is selected from the group consisting of H, F, CI, Br. I, CN, NO2, (G- G,)alkyl, (G-C3)haloalkyl, and (Ci-C3)alkoxy;

( ) R ¹² is selected from the group consisting of H, F, CI, Br, I, CN, NO2, (G~ C ₃ )alkyi, (Ci-C3)haloalkyl, and (G-C ₃ )a!koxy;

(O) R ¹³ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, (Ci- C3)aikyi, {Ci-C3)haloalkyi, and (G-C3)aikoxy;

(P) R ¹⁴ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, (G- C3)aikyi, (Ci-Csjhaloalkyl, and (G-C3)aikoxy;

(Q) X ³ is:

(1) N(R ^1¾ )(R ^1¾ ) wherein

(a) said R ^15a is selected from the group consisting of H, (G- G aikyl, (C2-C ₃ )alkenyi, (C2-C3)alkynyl, (Ci-C ₃ )haioaikyl, (G- G aikylphenyl, (Ci-C3)alkylO(G-C3)alkyl,

C ₃ )alkyi, and C{"0)(G-C ₃ )alkyl, and

(b) said R ¹⁵ is a substituted or unsubstituted phenyl, said substituted phenyl has one or more substituents selected from the group consisting of H, F, CI, Br, I, CN, NO2, NH2, OH, SF ₅ , (G- C ₃ )a!kyi, (G-C3)haloalkyl, (C2~C3)aikenyl, (C2-C ₃ )haloalkenyi, (G-

N = CHN(R ⁱ⁵ )(X ⁴ ), N(R ^15C )C(=0)0(X ⁴ ), N(R ^15c )S( = 0) ₂ (X ⁴ ),

N(R ^15c )C(-0)N{R ^15c )X ⁴ , N(R ^15c 3C(-S)N(R ^15c ) ₂ ,

N(R ^15c )C(-S)N(R ^15c )X ⁴ , N(R ^15c )(Ci-C ₃ )aikylX ⁴ , N{R ¹⁵ )(CH(0(G- C3)aikyl)2), N(R ^15c )({G-C ₃ )alkyi0C(-0)(G-C3)alkyl), N(R ^15c )((Ci- N(R ^15c )(C( = 0))2X ⁴ , N(R ^15c )(C( = 0)) ₂ OX ⁴ _f N(R ^15c )(C( = 0)) ₂ N(R ^15c )X ⁴ ,

N(R ^15c )C( = 0)N(R ^15c )C( = 0)0(R ^15c ),

C ₆ )alkyl)(C(=0)(Ci-C ₆ )alkyl), N((Ci-C ₃ )a!ky!0(Ci- C ₆ )alkyl)(C(=0)0(Ci-C6)alkyl),and N(R ^15c )C( = S)X ⁴ ,

(1) said R ^15c is each independently selected from the group consisting of H, (Ci-C3)alkyl, (Cz~C3)aikenyl, (C ₂ - C3)aikynyi, (Ci~C3)haioalkyi, (C2-C3) aloalkenyl, (Ci~ C ₃ )aikylphenyi, (Ci-C3)aikyiO(Ci-C ₃ )aikyl _; (Ci- and phenyl, optionally, for N(R ^15c ) ₂ said IM(R ^15c ) ₂ is a heterohydrocarbyi ring containing one nitrogen ring atom and three to five carbon ring atoms, where said ring may be saturated or unsaturated,

(2) said X ⁴ is selected from the group consisting of (Ct- C6)aikyl, iCt-Cs)haloa!kyi, (Ci-C3)alkylO(Ci-C3)alkyl, 0(Ci~ Ce)aikyl, (C3-C6)cycloalkyl, (Ci-C6)alkylphenyl, phenyl, aryi, and heterocycly!, each of which may be substituted with one or more of substituents selected from the group consisting of F, C!, Br, Ϊ, CN, OH, NO2, NH2, oxo, (Ci-C ₃ )alkyl, (Ci- C ₃ )haloalkyl, NH(Ci-C ₃ )alkyl, N((Ci-Cj)alkyl) ₂ , 0(Ci-C ₆ )alkyl, 0(Ci-C ₆ )haloalkyl,

N(R ^15c )S(=0) ₂ (R ¹⁵ ), S(=0) ₂ (R ¹⁵ ), (Ci-C ₃ )alkylO(Ci-C ₃ )alkyl, (C3-C6)cycloalkyl,

wherein (l)(a) and (l)(b) each said aikyl, alkenyi, alkynyl, cycloa!kyl, phenyl, aryi, and heterocyclyl, may be substituted with one or more substituents selected from the group consisting of F, G, Br, I, CN, OH, N0 ₂ , NH ₂ , NH(Ci-C ₃ )alkyl, N((Ci-C ₃ )alkyl) ₂ , 0(Ci- C ₆ )alkyi, (Ci-C ₃ )alkylO(Ci-C ₃ )alkyl, and (C ₃ -C ₆ )cycloalkyl;

N(R ^16a )(R ^16b ) wherein

(a) said R ^16a is selected from the group consisting of H, (Ci~ C ₃ )aikyi, (C ₂ -C ₃ )alkenyi, (C2-C ₃ )aikynyi, (Ci-C ₃ )haioaikyl, (Ci- C3)aikyiO(Ci-C3)aikyl, (Ci-C ₃ )alkylOC(=0)(Ci-C3)aikyi, and

(b) said R ^16b Is a substituted or unsubstituted (Ci-C8)alkyl, said substituted (Ci-Cs)alkyl has one or more substituents selected from the group consisting of F, C!, Br, I, CN, NO2, 0(Ci-Cs)alkyl, (Cs- Csjcycloalkyl, (Ci-Ca)alky!phenyi, (C?.-Cs)aikeny! _f (C2~Cs)aikyny!, S(Ci-Cs)aiky!, S(0)(Ci-C ₈ )alkyl, S(0)?.(Ci-Cs)alkyi _f Opheny!, 0(C ₂ - C ₈ )aikenyi, 0{Ci-Cs)alkyl(C3-C8)cyc!oaikyi _i 0(Ci-C ₈ )alkylphenyl, 0(Ci-Cs)alkyl(C3-C8)cycloalkyl, 0(Ci~C ₈ )aikyl,

C{-0)N{R ^15a )(Ci-C ₈ )a!ky!, N{R ¹⁵³ )C(-0)(Ci- C ₈ )a!ky! _; S(Ci-Cs)alkyl, S(0)(Ci-C ₈ )a!ky! _; S£0) ₂ (Ci-C ₈ )a!kyl,

S(0) ₂ NH ₂ , and N(R ^56a )S(0)2{Ci-C ₈ )a!kyi,

wherein (2)(a) and (2)(b) each alkyl, alkenyl, a!kynyi, cycioaikyl, and phenyl, may be substituted with one or more substituents selected from the group consisting of F, CI, Br, I, CM, OH, NH2, N0 ₂ , (Ci-Cs)a!kyl, (Ci-C ₃ )aikoxy, (Ci-Cs)haloalkyl, N((Ci-C ₈ )alkyi) ₂ , and C(=0)0(Ci-Ca)alkyl;

N(R ^17a )(N(R ⁱ⁷ )(R ^17c )) wherein

(a) said R ^17a is selected from the group consisting of H, (Ci- C ₃ )a!kyi, (C ₂ -C ₃ )a!kenyi, (C ₂ -C ₃ )a!kynyi, (Ci-C ₃ )haloalkyl, (Ci- C ₃ )a!kyiO(Ci-C ₃ )a!kyl,(Ci-C ₃ )aikylOC(=0)(Ci-C ₃ )aikyi, and

(b) said R ¹⁷ is selected from the group consisting of H, (Ci- C ₃ )aikyl, (C ₂ -C ₃ )alkenyi, (C ₂ -C ₃ )aikynyl, (Ci-C ₃ )haioaikyi, (Ci- C ₃ )aikylO(Ci-C ₃ )aiky!,(Ci-C ₃ )aikylOC(-0)(Ci-C ₃ )alkyl _; and

C(=0)(Ci-C ₃ )alkyl,

(c) said R ^17c is selected from the group consisting of H, substituted or unsubstituted phenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted (Ci-Ca)alky!, substituted or unsubstituted (C ₃ -C8)cycloaikyl, C(=0)X ⁵ , and C(=S)X ⁵ ,

(1) said X ⁵ is selected from the group consisting of substituted or unsubstituted phenyl, substituted or unsubstituted heterocyciy!, substituted or unsubstituted (Ci- Cs)alkyl, 0(Ci-Cs)alkyl, 0(Ci-Cs)haloalkyl, 0(substituted and unsubstituted)phenyl, N(R ^17a )(Ci-C ₈ )alkyl, N(R ^17a )(Ci- C ₈ )haloalkyi, N(R ^17i, )(C ₃ -C ₈ )cycloalkyi, N(R ^17a )(substltuted and unsubstituted phenyl), and (C ₃ -C6)cycloalkyi,

(2) said substituted phenyl in (3)(c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, N0 ₂ , OH, (Ci-C ₃ )a!koxy, and (Ci-C ₃ )a!kyl,

(3) said substituted heterocyclyl In (3)(c) has one or more substituents selected from the group consisting of F, CI, Br, !, CN, NO2, OH, (Ci-C ₃ )a!koxy, and (Ci-C ₃ )alkyl, (4) said substituted (Ci-Cs)alkyl In (3)(c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, NO2, NH2, 0(Ci-C ₈ )aikyl, (C ₃ -Cs)cycioaikyl, phenyl, (C2-C8)aikenyl, (C2-C3)alkynyi, S(Ci-Cs)alkyl, S(0)(Ci-Cs)alkyl, S(0)2(Ci-Cs)alkyl, Ophenyl, 0(C ₂ - C8)alkenyl, 0(Ci-C8)aikyl(C3-Cs)cyc!oalkyl, 0(Ci- C ₈ )aikylphenyl, 0(Ci-C ₈ )alkyl(C3-C ₈ )cycloalkyl, C(=0)l\IH(G- C ₈ )aikyl, S(0) ₂ NH ₂ , NH(Ci-C ₃ )alkyl,

(5) said substituted (C3-C8)cycloaikyi has one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, (Ci-C3)alkoxy, and (Ci-C3)alkyl,

wherein (2)(a), (2)(b), and (2)(c) each alkyl, alkenyl, alkynyl, cycloaiky!, haloalky!, phenyl, and heterocyclyl, may be optionally substituted with one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, H ₂ , NO2, (Ci-Cs)alkyi, (Ci- Cs)a!koxy, (Ci-Cs) aloalkyl, N((Ci-C ₈ )aiky!)2, and C(=0)0(Ci- C3)alkyi, optionally (N(R ^17b )(R ^17c )) is a heterohydrocarbyi ring containing one nitrogen ring atom and three to five carbon ring atoms, where said ring may be saturated or unsaturated;

N(R ^18a )(N=C(R ¹⁸ )(R ^18c )

(a) said R ^18a is selected from the group consisting of H, (Ci- C ₃ )aikyi, (C2-C3)alkenyi, (C2~C ₃ )aikynyi _f (Ci-C ₃ )alkyiO(Ci-

(b) said R ¹⁸ Is selected from the group consisting of H and (Ci- C ₃ )aikyi,

(c) said R ^18c is selected from the group consisting of substituted or unsubstituted phenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted (Ci-Cs)aikyi, substituted or unsubstituted (C3-Cs)cycloalkyl,

(1) said substituted phenyl in (4)(c) has one or more substituents selected from the group consisting of F, C!, Br, I, CN, NO2, OH, (Ci-C ₃ )aikoxy, (Ci-Csjaikyi, (Ci- C ₃ )haioalkoxy, and (Ci-C3)haioalkyi,

(2) said substituted heterocyclyl In (4)(c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, NO2, OH, (Ci-C ₃ )alkoxy, (Ci-C ₃ )alkyl, (Ci- C3)haloalkoxy, and (Ci-C ₃ )haloalkyl, (3) said substituted (Ci-C8)aikyi has one or more

substituents selected from the group consisting of F, CI, Br, I, CN, NQz, 0(Ci-C ₈ )alkyl, (C ₃ -Cs)cycioaikyl, phenyl, (Cz- C8)alkenyl, (Cz-Cs)aikynyl, S(Ci-Cs)alkyl, S(0)(Ci-Cs)alkyi, S(0)z(Ci-Cs)alkyl, Ophenyl, 0{Cz-Cs)alkenyl, 0(Ci- C8)alkyl(C3-Cs)cycloalkyl, 0{Ci-Cs)alkylphenyl, 0(Ci- C ₈ )aikyl(C3-C ₈ )cycioaikyl, C(-0)NH(Ci-C ₈ )a!kyi,

(4) said substituted (C3-C ₈ )cycloaiky! has one or more substituents selected from the group consisting of F, CI, Br, Ϊ, CN, OH, (Ci-C3)aikoxy, and (Ci-C3)alkyl,

wherein (4)(a), (4)(b), and (4)(c) each alkyl, alkenyl, alkynyl, cycloa!kyl, haloalkyl, phenyl, and heterocyc!yl may be substituted with one or more substituents selected from the group consisting oi F, CI, Br, I, CN, OH, Hz, NO2, (Ci-Ce)alkyl, (Ci-Cs)aikoxy, (Ci- Cs) aloalkyl, N((Ci-C8)aiky!)z, and optionally C(R ^iS )(R ^t8c ) is a hydrocarbyl ring containing three to five carbon ring atoms, where said ring may be saturated or unsaturated, optionally, one or more of said carbon ring atoms may Instead be nitrogen, oxygen, or sulfur atom;

and N-oxides, agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, crystal polymorphs, isotopes, resolved stereoisomers, tautomers, pro-insecticides, of the molecules of Formula One.

In another embodiment a molecule according to Formula One wherein said molecule has the following formula

In another embodiment a molecule according to Formula One and Formula Two wherein R ¹ Is selected from the group consisting of H, F, CI, Br, SF5, and CF3.

In another embodiment a molecule according to Formula One and Formula Two wherein R ² is selected from the group consisting of H, F, CI, Br, SFs, and CF3. In another embodiment a moiecuie according to Formula One and Formula Two wherei n R ³ Is selected from the group consisting of H, F, CI, Br, SFs, and CF3,

In another embodiment a molecule according to Formula One and Formula Two wherei n R ls selected from the group consisting of H, F, CI, Br, SF5, and CF3.

In another embodiment a molecule according to Formula One and Formula Two wherei n R ⁵ is selected from the group consisting of H, F, CI, Br, SFs, and CF3.

In another embodiment a moiecuie according to Formula One and Formula Two wherei n at least one of R ² , R ³ , and R ⁴ , Is SFs.

In another embodiment a moiecuie according to Formula One and Formula Two wherei n R ⁷ Is CI ,

In another embodiment a moiecuie according to Formula One and Formula Two wherei n R ⁸ is CI .

In another embodiment a molecule according to Formula One and Formula Two wherei n R ⁷ , and R ⁸ are not the same.

In another embodiment a molecule according to Formula One and Formula Two wherei n Q ¹ Is 0,

In another embodiment a molecule according to Formula One and Formula Two wherei n Q ² Is 0,

In another embodiment a molecule according to Formula One and Formula Two wherei n R ¹⁰ Is H .

In another embodiment a moiecuie according to Formula One and Formula Two wherei n R ¹¹ Is H .

In another embodiment a moiecuie according to Formula One and Formula Two wherei n R ¹² Is selected from the group consisting of H, F, CI, CH3, and CF3.

In another embodiment a moiecuie according to Formula One and Formula Two wherei n R ¹³ Is selected from the group consisting of F, CI, CH3, and OCH3.

In another embodiment a molecule according to Formula One and Formula Two wherei n R ¹⁴ is selected from the group consisting of H, F, and CI .

In another embodiment a molecule according to Formula One and Formula Two wherei n :

R ¹ is selected from the group consisti ng of H, F, CI, Br, SFs, and CF3;

R ² is selected from the group consisti ng of H, F, CI, Br, SFs, and CF3;

R ³ is selected from the group consisti ng of H, F, CI, Br, SF5, and CF3;

R ⁴ is selected from the group consisti ng of H, F, CI, Br, SFs, and CF3;

R ⁵ is selected from the group consisti ng of H, F, Ci, Br, SFs, and CF«;

R ⁷ is CI ;

R ⁸ Is CI ;

Q ^"1 is 0; Q ² is 0;

R ¹⁰ Is H;

R ⁿ Is H;

R ¹² Is selected from the group consisti ng of H, F, Ci, CH3, and CFs;

R ¹³ is selected from the group consisti ng of F, CI, CH3, and OCH3; and

R ¹⁴ is selected from the group consisti ng of H, F, and C! ,

In another embodiment a molecule according to Formula One and Formula Two wherei n X ³ Is N(R ^1¾ )(R ^15b ) .

In another embodiment a molecule according to Formula One and Formula Two wherei n X ³ Is N(R ^15a )(R ¹⁵ ) and said R ^15b is selected from the group consisting of

INi(R ^15c )C(=0)(R ^15c ) and INi(R ^i5c )C(=0)X ⁴ , said R ^i5c are each Independently selected from the group consisting of (Ci-C3)alkyi, (C2-C3)alkenyl, (Ci-C3)haloal kyl, and (Ci- C3)alkylO(Ci-C3)alkyl, said X ⁴ is selected from the group consisting of (Ci-C6)alkyi, (Ci- C6)haioai kyl, and (Ci-C3)alkylO(Ci-C3)alkyl, and each said alkyi, ha!oalkyl , and aikenyl, may be substituted with one or more substituents selected from the group consisting of F, Ci, CN, and (C3-C6)cycloalkyi , For avoidance of doubt this Includes, for example, substituting a ha!oaikyl, which includes the term "al kyi" with one or more substituents, for example CN or (Cs-Cejcycloaikyl ,

In another embodiment a molecule according to Formula One and Formula Two wherei n X ³ Is N(R ^16a )(R ^15b ) .

In another embodiment a molecule according to Formula One and Formula Two wherei n X3 is N(R ^17a )(N (R ^17b )(R ^17c )) .

In another embodiment a molecule according to Formula One and Formula Two wherei n X ³ Is N(R ^18a )(N =C(R ^iS )(R ^18c ) .

In another embodiment a molecule selected from Table 2, preferably a molecule selected from the group consisti ng of F1007, F1079, F1108, F1147, F1185, F1234, F1241, F1246, F1247, F1248, F1250, F1460, F1465, F1593, F1598, F1613, F1627, F1657, F1694, F1696, F1697, F1702, F1703, F1704, F1708, F1711, F1740, F2016, F2017, F2021, F2027, F2039, F2042, F2078, and F2081.

The molecules of Formula One may exist in different geometric or optica! isomeric or different tautomeric forms. One or more centers of chiraiity may be present In which case molecules of Formula One may be present as pure enantiomers, mixtures of enantiomers, pure diastereomers or mixtures of diastereomers. It will be appreciated by those skilled in the art that one stereoisomer may be more active than the other stereoisomers. Individual stereoisomers may be obtained by known selective synthetic procedures, by conventional synthetic procedures using resolved starting materials, or by conventional resolution procedures. There may be double bonds present i n the molecule, in which case compounds of Formula One may exist as single geometric isomers (c/ ^' s or trans, E or Z) or mixtures of geometric isomers (c/ ^' s and trans, E and Z) , Centers of tautomerisation may be present. This disclosure covers all such Isomers, tautomers, and mixtures thereof, in all proportions. The structures disclosed in the present disclosure maybe drawn in only one geometric form for ciarity, but are intended to represent all geometric forms of the molecule.

PREPARATION OF MOLECULES OF FOR ULA ONE

Preparation of cyeioprapyl earboxyiic acids

Stilbenes 1-1, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , and R ⁹ are as previously disclosed, may be treated with a base such as sodium hydroxide i n the presence of a carbene source such as chloroform or bromoform and a phase transfer catalyst such as /V-benzyl- , V-diethylethanami nium chloride in a polar protic solvent such as water at

temperatures from about 0 °C to about 40 °C to provide diaryl cyclopropanes 1-2, wherei n R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , and R ⁹ are as previously disclosed (Scheme 1, step a) . Alternatively, stilbenes 1-1, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , and R ⁹ are as previously disclosed, may be treated with a salt such as sodium Iodide i n the presence of a carbene source such as trimethyl (tnfl uoromethyl)silane in a polar aprotic solvent such as tetrahydrofuran at temperatures from about 80 °C to about 120 °C under microwave irradiation conditions to provide diary! cyclopropanes 1-2, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are as previously disclosed (Scheme 1, step a) . Treatment of diary! cyclopropanes 1-2 with a transition meta! such as rutheni um(III) chloride i n the presence of a stoichiometric oxidant such as sodium periodate in a solvent mixture preferably water, ethyl acetate, and acetonitriie at temperatures from a bout 0 °C to about 40 °C may provide cyc!opropyi carboxyiic acids 1-3, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , and R ⁹ are as previously disclosed (Scheme 1, step b) .

Preparation of sti benes

Stilbenes 1-1 may be prepared by several different methods as outlined in Scheme 2, Phenyl carbonyls 2-1, wherein R ¹ , R ² , R ³ , R ⁴ _f R ⁵ , and R ⁶ are as previously disclosed, may be treated with aikoxy benzyl phosphonates 2-2 in the presence of a base such as sodi um methoxide in a polar aprotic solvent such as N,N- dimethylformamide at temperatures from about - 10 °C to about 30 °C and subsequently heated to 40 °C to about 80 °C to provide stil benes 1- 1 (Scheme 2, step a) . Aryi halides 2-3, wherein R ¹ , R ² , R ³ , R ⁴ , and R ⁵ are as previously disclosed, may be treated with vinyl benzenes 2-4, wherein R ⁶ and R ⁹ are as previously disclosed, in the presence of a transition metal catalyst such as pailadlum(II) acetate and a bisphospni ne ligand such as l, l'-bis(diphenyl phosphino)ferrocene in a basic solvent such as triethylamine at temperatures from about 60 °C to about 100 °C to provide stilbenes 1-1 (Scheme 2, ste fe) .

In yet another embodi ment, stil benes 1-1 may also be prepared by the VVittig olefinatlon method (Cha!al, M . ; Vervandier-Fasseur, D. ; Meunier, P. ; Cattey, H. ; Hierso, J. -C. Tetrahedron 2012, 68, 3899-3907) as outlined i n Scheme 2.5. Phenyl carbonyis 2~ 1, wherei n R ¹ , R ² , R ³ , R ⁴ , and R ^s are as previously disclosed and R ^s Is H, may be treated with aikoxy benzyl triphenylphosphonium chlorides 2.5-2 in the presence of a base such as n-butyl lithium in a polar aprotic solvent such as tetrahydrofuran at temperatures from about -78 °C to ambient temperature to provide stilbenes 1-1 (Scheme 2, 5, step a) .

Preparation of cycSopropy! amides Cydopropyl amides 3-3, wherein Q ¹ is 0, and R ¹ , R ² , R ³ , R ⁴ _f R ⁵ , R ⁶ , R ⁷ , R ⁸ _f R ⁹ _f R ^iQ , R ⁿ , R ¹² , R ¹³ , R ¹⁴ , Q ² , and X ³ are as previously disclosed, may be prepared by treatment with amines or amine salts 3-2, wherein R ¹⁰ , R ^u , R ¹² , R ¹³ , R ¹⁴ , Q ² , and X ³ are as previously disclosed, and activated carboxylic acids 3-1, wherein A is an activating group, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , and R ⁹ are as previously disclosed, with a base, such as triethyiami ne, diisopropylethylamine, 4-methylmorpholine, or 4- dimethylaminopyridine in an anhydrous aprotic solvent such as dichloromethane, tetrahydrofuran, 1,2-dichloroethane, di methyiformamide, or any combination thereof, at temperatures between about 0 °C and about 120 °C (Scheme 3, step a).

Carboxyl ic acids 3-1, wherein A is an activating group, may be an acid halide, such as an acid chloride, an acid bromide, or an acid fluoride; a carboxylic ester, such as a para-nitrophenyl ester, a pentafiuorophenyl ester, an ethyl

(hydroxyi mino)cyanoacetate ester, a methyl ester, an ethyl ester, a benzyl ester, an N- hydroxysuccinimidyl ester, a hydroxybenzotriazol- l-yl ester, or a hydroxypyridyltriazol- 1-yl ester; an O-acyl lsourea; an acid anhydride; or a thioester. Acid chlorides may be prepared from the correspondi ng carboxylic acids by treatment with a dehydrating chlorinating reagent, such as oxalyi chloride or thlonyl chloride. Activated carboxylic esters 3-1 may be prepared from carboxylic acids in situ with a uroni um salt, such as 1- [bis(dimethylamino)methylene]- lH- l,2,3-triazolo[4,5-b]pyridi niurn 3-oxid

hexafluorophosphate (HATU), 0-(benzotriazol- l-yi)-/V _/ V _/ /V' _/ /V ^, -tetramethyluronium hexafluorophosphate (HBTU), or (l-cyano-2-ethoxy-2- oxoethylidenaminooxy)dimethylamino-morpholi no-carbeniurn hexafluorophosphate (COMU) . Activated carboxylic esters 3-1 may also be prepared from carboxyl ic acids in situ with a phosphonlum salt such as benzotriazoi- l-yl-oxytripyrrolidi nophosphoni um hexafluorophosphate (PyBop) . Activated carboxylic esters 3-1 may also be prepared from carboxylic acids in situ with a coupling reagent such as l-(3-dimethylamino propyl)-3-ethylcarbodiimide, or dicyc!ohexylcarbodiimide in the presence of a triazole such as hydroxybenzotriazole- monohydrate (HOBt) or l-hydroxy-7-azabenzotriazole (HOAt) . O-Acylisoureas may be prepared with a dehydrating carbodim!de such as i-(3- dimethylamino propyl)-3-ethylcarbodii mide or dicyciohexylcarbodiimide. Activated carboxyl ic esters 3-1 may also be prepared from carboxylic acids in situ with a coupling reagent such as 2-chloro- l,3-dimethylimidazolidi nium hexafluorophosphate (C1P) i n the presence of a triazole such as l-hydroxy-7-azabenzotriazoie ( HOAt). Activated carboxyl ic esters 3-1 may also be prepared from carboxylic acids in situ with a coupling reagent such as 2,4,6-tn propyl- l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P ^® ) i n the presence of a base such as pyridine.

Cydopropyl amides 3-3, wherein R ^15b contains a sulfide and R ¹⁵³ is as previously disclosed, may be oxidized to the correspondi g sulfoxide or sulfone by treatment with about one equivalent of meta-chloroperoxybenzoic acid in a polar aprotic solvent such as dichloromethane (sulfoxide) or about two equivalents of meta-chloroperoxybenzoic acid (sulfone) at temperatures between about 0 °C to about 40 °C. Alternatively, cyciopropyl amides 3-3, wherein R ^15b contains a sulfide may be oxidized to the correspondi ng sulfoxide or sulfone by treatment with one equivalent of sodi um perborate In a protic solvent such as acetic acid (sulfoxide) or two equivalents of sodium perborate (su lfone) . Preferably, the oxidation will be performed at temperatures between about 40 °C to about 100 °C usi ng about 1.5 equivalents of sodi um perborate to provide

chromatographically separable mixtures of sulfoxide and sulfone cyciopropyl amides 3-3. Alternatively, cyciopropyl amides 3-3 contai ning a sulfide may be oxidized to the corresponding suifl!imine by treati ng with about one equivalent of an ami ne such as cyanamide, about one equivalent of a base such as potassium ierf-butoxide, and between one and two equivalents of an oxidant such as /V-bromosuccinimide in a polar protic solvent such as methanol at temperatures between about 0 °C to about 40 °C. The suifilimine may be further oxidized to the correspondi ng su!foximine by treatment with about one equivalent of meta-chloroperoxybenzoic acid and about two equivalents of potassium carbonate in a mixture of solvents such as 2 : 1 : 1

ethanol : dichloromethane: water at temperatures between about 0 °C to about 40 °C.

Cyciopropyl amides 3-3, wherein R ³ is NO?, may be reduced to the corresponding M Hz by treatment with an acid source, such as ammonium chloride, and iron i n a polar protic solvent, such as methanol, water, or any combination thereof, at temperatures from about 20 °C to about 60 °C.

Amines or ami ne salts 3-2, wherei n Q ² is O may be treated directly with a source of sulfur, such as phosphorus pentasulfide or 2,4-bis(4-methoxyphenyl)- l,3,2,4- ditniadiphosphetane 2,4~dlsuifide (Lawesson's reagent) with or without additives such as

1, 1, 1,3,3,3-hexamethyldisoloxane, In an aprotic solvent chosen from tetrahydrofuran, dichloromethane, chloroform, toluene, or pyridine, at temperatures from about 40 °C to about 120 °C to provide amines or amine salts 3-2, wherein Q ² is S,

3-2

Cyciopropyl amides 4-3, wherein Q ² is 0, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ⁱ⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and X ³ are as previous!y disclosed, may be prepared by treatment with amines or amine sa!ts 4-2, wherein X ³ is as previously disclosed, and activated carboxyi ic acids 4-1, wherein A is an activating group, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ^{1 3} , and R ¹⁴ are as previously disclosed, with a base, such as triethyiamlne, diisopropyiethyiamine, 4-methylmorphoiine, pyridine, or 4- dimethy!aminopyridine in an anhydrous aprotic solvent such as dichioromethane, tetrahydrofuran, 1,2-dichloroethane, di methylformamide, or any combination thereof, at temperatures between about 0 °C and about 120 °C (Scheme 4, step a) .

Activated carboxyi ic acids 4-1 may be an acid halide, such as an acid chloride, an acid bromide, or an acid fluoride; a carboxyiic ester, such as a para-nitrophenyl ester, a pentafiuorophenyl ester, an ethyl (hydroxyimino)cyanoacetate ester, a methyl ester, an ethyl ester, a benzyl ester, an V-hydroxysucdnlmldyl ester, a hydroxybenzotrlazol- l-yl ester, or a hydroxypyridyltriazol- l-yl ester; an O-acylisourea ; an acid anhydride; or a thioester. Acid chlorides may be prepared from the corresponding carboxyiic acids by treatment with a dehydrating chlorinating reagent, such as oxalyl chloride or thionyi chloride. Activated carboxyiic esters 4-1 may be prepared from carboxyiic acids in situ with a uronium salt, such as l-[bis(dimethylamino)methylene]- lH- l,2,3-triazolo[4,5- bjpyrldinium 3-oxld hexafl uorophosphate (HATU), 0-(benzotriazol- l-yl)- V _/ /V _/ /V' _/ V ^/ - tetramethyluronium hexafluorophosphate (HBTU), or ( l-cyano-2-ethoxy-2- oxoethylidenaminooxy)dimethylamino-morpholi no-carbeniurn hexafluorophosphate (COMU) . Activated carboxy!ic esters 4-1 may a!so be prepared from carboxylic acids in situ with a phosphonium salt such as benzotriazol- l-yl-oxytripyrrolidi nophosphoni um hexafiuorophosphate (PyBop) . Activated carboxylic esters 4-1 may also be prepared from carboxylic acids in situ with a coupling reagent such as l-(3-dimethylamino propyl)-3-ethylcarbodiimide, or dicydohexy!carbodiimide in the presence of a triazo!e such as hydroxybenzotriazole- monohydrate (HOBt) or l-hydroxy-7-azabenzotriazole (HOAt) . O-Acylisoureas may be prepared with a dehydrating carbodimide such as l-(3- dimethy!amino propyi)-3-ethylcarbodli mide or dicyc!ohexylcarbodiimide, Activated carboxyl ic esters 4-1 may also be prepared from carboxylic acids in situ with a coupling reagent such as 2-chloro- l,3-dimethylimidazolidi nium hexafiuorophosphate (CIP) i n the presence of a triazole such as l-hydroxy-7-azabenzotriazole (HOAt), Activated carboxyl ic esters 4-1 may also be prepared from carboxylic acids in situ with a coupling reagent such as 2,4,6-tri propyl- l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P ^® ) i n the presence of a base such as pyridine.

Scheme 4

HX ^{3 4"3}

4-2

Cyclopropyl amides 5-2, wherein X ³ is N(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including N(R ^15c )z, wherein one of R ^15c is a (Ci- C ₃ )alkylphenyl ; Q ² is 0, R ¹ , R ^z , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ^{1 3} , R ¹⁴ , and R ^15a are as previously disclosed, may be prepared by treatment of amines 5-1, wherei n X ³ is N(R ^15a )(R ^15b ) and R ^15b Is a substituted phenyl having one or more substituents incl uding N(R ^15c ) ₂ , wherei n R ^15c is H; Q ² is O, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R" , R ¹² , R ¹³ , R ¹⁴ , R ^15a are as previously disclosed, with an aldehyde such as

benza!dehyde in the presence of a reducing agent such as sodium cyanoborohydride In a solvent such as methanol, with or without an acid, such as acetic acid, at about room temperature (Scheme 5, step a) .

Cyciopropyi amides 5-4, wherein X ³ is N(R ^15a )(R ¹⁵ ) and R ^15b is a substituted phenyl having one or more substituents including N(R ^15c )z, wherein one or more of R ^15c is (Ci-C ₃ )alkyl ; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^i5a are as previously disclosed, may be prepared by treatment of amines 5-1, wherein X ³ Is N(R ^15a )(R ¹⁵ ) and R ^15b is a substituted phenyl having one or more substituents including N(R ^15c ) ₂ , wherei n R ^{i 5c} is H; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ^1G , R ¹¹ , R ^1Z , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, with an alkylating agent 5-3 such as an a!kyl halide in the presence of a base, such as triethylamine, diisopropyiethylamine, 4- methylmorphoi lne, 4-dimethyiami nopyridlne, or pyridine, In an anhydrous aprotic solvent such as dichioromethane, tetrahydrofuran, 1,2-dich!oroethane, N,N- dimethylformamide, or any combi nation thereof, at temperatures between about 0 °C and about 120 °C (Scheme 5, step b) .

Cyciopropyi amides 5-6, wherein X ³ is N(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including N (R ^15c )C( = 0)X ⁴ ; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ⁱ⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, may be prepared by treatment of amines 5-1, wherei n X ³ is N(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including N(R ^15c )2, wherein R ^i5c is H; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^i5a are as previously disclosed, with an activated carboxylic acid 5-5 wherein A is an activating group and a base, such as triethylamine, diisopropyiethylamine, 4-methylmorpholine, 4- dimethy!aminopyridine, or pyridine, in an anhydrous aprotic solvent such as

dichioromethane, tetrahyd ofu a , 1,2-dlchloroethane, A ,W-dimethylformamide, or any combination thereof, at temperatures between about 0 °C and about 120 °C (Scheme 5, step c).

Activated carboxyl ic acids 5-5, may be an acid halide, such as an acid chloride, an acid bromide, an acid fluoride, or a cbloroformate; a carboxylic ester, such as a p- nitrophenyl ester, a pentafl uorophenyl ester, an ethyl (hydroxyimino)cyanoacetate ester, a methyl ester, an ethyl ester, a benzyl ester, an W-hydroxysucci nimidyl ester, a hydroxybenzotriazol- l-yl ester, or a hydroxypyridyltriazol- l-yl ester; an Q-acy!isourea; an acid anhydride; or a thloester. Acid chlorides may be prepared from the

corresponding carboxylic acids by treatment with a dehydrating chlori nating reagent, such as oxaiyi chloride or thionyl chloride. Activated carboxyl ic esters 5-5 may be prepared from carboxyl ic acids in situ with a uroni um salt, such as 1-

[bis(dimethylamino)methylene]- lH- l,2,3-triazolo[4,5-b]pyridi nium 3-oxid

hexafluorophosphate (HATU), 0-(benzotriazol- l-yl)-/V _/ /V _/ /V _/ /V -tetramethyl uronium hexafluorophosphate (HBTU), or (l-cyano-2-ethoxy-2~ oxoethylidenaminooxy)dimethylamino-morpholi no-carbenium hexafiuorophosphate (COMU) . Activated carboxyiic esters 5-5 may a!so be prepared from carboxyiic acids in situ with a phosphonium sait such as benzotriazol- l-yl-oxytripyrrolidi nophosphoni um hexafiuorophosphate (PyBop) . Activated carboxyiic esters 5-5 may also be prepared from carboxyiic acids in situ with a coupling reagent, such as l-(3-dimethylamino propyl)-3-ethylcarbodiimide or dlcyc!ohexylcarbodiimlde, in the presence of a triazo!e such as hydroxybenzotriazole- monohydrate (HOBt) or l-hydroxy-7-azabenzotriazole (HOAt) . 0~Acylisoureas may be prepared with a dehydrating carbodimide such as i-(3- dimethy!aminopropyi)-3~ethylcarbodiimide or dicyclohexylcarbodiimide. Activated carboxyi ic esters 5-5 may also be prepared from carboxyiic acids in situ with a coupling reagent such as 2-chloro- l,3-dimethylimidazolidi nium hexafiuorophosphate (CIP) i n the presence of a trlazoio! such as l-hydroxy-7-azabenzotriazole (HOAt) , Activated carboxyi ic esters 5-5 may also be prepared from carboxyiic acids in situ with a coupling reagent such as 2,4,6-tri propyl- l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P ^® ) i n the presence of a base such as pyridine. In each 5-5 above, X ⁴ , Is as previously defined.

Scheme 5

Cyclopropyl amides 6-4, wherein X ³ is N(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including N(R ^{1 c} )2, wherein R ^15c is H; Q ² is 0, R ^l , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ _f Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^{"! ¾} are as previously disclosed, may be prepared by treatment of 6-1, wherein X ³ is N(R ^15a )(R ^{i 5} ) and R ^15b Is a substituted phenyl having one or more substituents including NO2 R ^"! , R ² , R ³ , R ⁴ , R ⁵ , R ⁵ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ⁱ⁴ , and R ^15a are as previously disclosed, with a metal such as palladium on carbon in the presence of a reduci ng agent such as hydrogen gas in a solvent such as ethyl acetate or with a metal such as iron in the presence of a reducing agent such as ammoni um chloride in a solvent mixture such as methanol and water at a temperature of about 25 °C to about 60 °C (Scheme 6, step a).

Alternatively, cyclopropyl amides 6-4, wherein X ³ is N (R ^{1 a} )(R ^15b ) and R ¹ Is a substituted phenyl having one or more substituents Including N(R ^{1 c} )2, wherein R ^{i 5c} is H; Q ² is 0, R\ R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ³ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^i5a are as previously disclosed, may be prepared by treatment of 6-2, wherein X ³ is N(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents includi ng

N(R ¹⁵ )C(-0)0(Ci-C6)alkyl wherein R ^15c is H; Q ² is O, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, with an anhydrous acid sol ution such as hydrochloric acid in 1,4-dioxane and dichloromethane at a temperature of about 25 °C (Scheme 6, step c) ,

Alternatively, cyclopropyl amides 6-4, wherein X ³ is N (R ^15a )(R ^l5b ) and R ^15b Is a substituted phenyl having one or more substituents including N(R ^15c )2, wherein R ^i5c is H; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^i5a are as previously disclosed, may be prepared by treatment of 6-3, wherein X ³ is N(R ^15a )(R ¹⁵ ) and R ^15b is a substituted phenyl having one or more substituents including N (C(=0)0(G- C ₆ )alkyl) ₂ ; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, with an anhydrous acid solution such as hydrochloric acid i n 1,4-dioxane and dichloromethane at a temperature of about 25 °C (Scheme 6, step c) , Cyclopropyl amides 6-6, wherein X ³ is l\(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including N H(R ^15c ) wherein R ^15c is (G-C3)alkyi ; Q ² is 0, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, may be prepared by treatment of 6-5 wherein X ³ Is N(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including

wherein R ^15c is (Ct-C ₃ )ai kyi ; R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , 0 R ^t0 , R ⁿ , R ¹² , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, with an anhydrous acid sol ution such as hydrochloric acid in 1,4-dioxane and dichloromethane at a temperature of about 25 °C (Scheme 6, step d).

Scheme 6

Cyc!opropy! amides 7-2, wherein X ³ is N(R ^{t a} )(R ^15b ) and R ^{t 5} is a substituted phenyl having one or more substituents including a (C2-C3)aikenyl or (C2-C3)haloalkenyl group; Q ² is 0; R ¹ , R ² _; R ³ _; R ⁴ _; R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ⁱ⁰ , R ¹¹ , R ^iZ , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, may be prepared by treatment of aryi haiides 7-1, wherein X ³ is |Ni(R ^15a )(R ^15b ) and R ^15b is a substituted phenyl having one or more substituents including Br or Ϊ; Q ² is 0; R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^15a are as previously disclosed, with a stannane such as 7-2, wherein R ^15c is a (C2-C3)alkenyl or (C2-C3)haloai kenyl group. I n the presence of a metal catalyst such as

bis(triphenylphosphine)palladium(II) dichloride in an aprotic solvent li ke 1,4-dioxane at a

Cyclopropyl amides 8-3, wherein Q ¹ is 0, and R ¹ . R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Rn _{f a re as} previously disclosed, may be prepared by treatment of amines or ami ne salts 8-2, wherein R ¹⁰ , R ⁿ , R ¹² , R ¹³ , R ¹⁴ , Q ² , R ¹⁷³ , R ^17b , and R ^17c are as previously disclosed, and activated carboxy!lc acids 8-1, wherei n A Is an activating group, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , and R ⁹ are as previously disclosed, with a base, such as triethyiamine, d!isopropy!ethyiamine, 4- methylmorphol ine, or 4-di methylaminopyrldine in an anhydrous aprotic solvent such as dichloromethane, tet ra hydrofu ran, 1,2-dlchloroethane, dimethylformamide, or any combination thereof, at temperatures between about 0 °C and about 120 °C (Scheme 8, step a) .

Activated carboxyl ic acids 8-1 may be an acid haiide, such as an acid chloride, an acid bromide, or an acid fluoride; a carboxylic ester, such as a para-nitrophenyi ester, a pentafiuorophenyl ester, an ethyl (hydroxyimino)cyanoacetate ester, a methyl ester, an ethyl ester, a benzyl ester, an W-hydroxysucclnimidyi ester, a hydroxybenzotrlazoi- 1-yl ester, or a hydroxypyrldy!triazol- l-yl ester; an G-acylisourea ; an acid anhydride; or a thioester. Acid chlorides may be prepared from the corresponding carboxylic acids by treatment with a dehydrating chlorinating reagent, such as oxaiyl chloride or t ionyl chloride. Activated carboxylic esters 8-1 may be prepared from carboxylic acids in situ with a uronium salt, such as l-[bis(dimethylamino)methylene]- lH- l,2,3-triazolo[4,5- bjpyrldinium 3-oxld hexafl uorophosphate (HATU), 0-(benzotriazol- l-yl)-/V,/V _/ /V ,/V - tetramethyluronium hexafluorophosphate (HBTU), or ( l-cyano-2-ethoxy-2- oxoethylidenaminooxy)dimethylamino-morpholi no-carbeniurn hexafluorophosphate (COMU) . Activated carboxyiic esters 8-1 may a!so be prepared from carboxyiic acids in situ with a phosphonium sait such as benzotriazol- l-yl-oxytripyrrolidi nophosphoni um hexafluorophosphate (PyBop) . Activated carboxyiic esters 8-1 may also be prepared from carboxyiic acids in situ with a coupling reagent such as l-(3-dimethylamino propyl)-3-ethylcarbodiimide, or dicyciohexy!carbodiimide in the presence of a triazo!e such as hydroxybenzotriazole- monohydrate (HOBt) or l-hydroxy-7-azabenzotriazole (HOAt) . 0~Acylisoureas may be prepared with a dehydrating carbodimide such as l-(3- dimethy!amino propyl)-3-ethylcarbodii mide or dicydohexy!carbodiimide, Activated carboxyi ic esters 8-1 may also be prepared from carboxyiic acids in situ with a coupling reagent such as 2-chloro- l,3-dimethylimidazolidi nium hexafluorophosphate (CIP) i n the presence of a trlazoie such as l-hydroxy-7-azabenzotriazole (HOAt). Activated carboxyi ic esters 8-i may also be prepared from carboxyiic acids in situ with a coupiing reagent such as 2,4,6-tri propyl- l,3,5,2,4,6-trioxatriphosphi nane 2,4,6-trioxide (T3P ^® ) i n the presence of a base such as pyridine.

Scheme 8

8-2

Cyciopropyl amides 9-3, wherein Q ² is 0, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ⁱ⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ^17a , R ^17b , and R ^17c are as previously disclosed, may be prepared by treatment of hydrazines or hydrazine salts, 9-2, wherein R ^17a , R ¹⁷ , and R ^17c are as previously disclosed, and activated carboxyiic acids 9-1, wherein A is an activating group, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , and R ¹⁴ are as previously disclosed, with a base, such as triethy!amine, dlisopropylethylamlne, 4~ methylmorphol ine, or 4-dimethylaminopyridine in an anhydrous aprotic soivent such as dichloromethane, tetrahydrofuran, 1,2-dichloroethane, dimethylformamide, or any combination thereof, at temperatures between about 0 °C and about 120 °C (Scheme 9, step a) .

Activated carboxyi ic acids 9-1 may be an acid haiide, such as an acid chloride, an acid bromide, or an acid fluoride; a carboxyiic ester, such as a para-nitropheny! ester, a pentafluorophenyl ester, an ethyl (hydroxyimino)cyanoacetate ester, a methyl ester, an ethyl ester, a benzyl ester, an AZ-hydroxysucclnlmldyi ester, a hydroxybenzotriazol- 1-yl ester, or a hydroxypyridyltriazol- l-yl ester; an O-acylisourea ; an acid anhydride; or a thioester, Acid chlorides may be prepared from the corresponding carboxyiic acids by treatment with a dehydrating chlorinating reagent, such as oxalyl chloride or thionyi chloride. Activated carboxyiic esters 9-1 may be prepared from carboxyiic acids in situ with a uranium salt, such as l-[bis(dimethylamino)methylene]- lH- l,2,3-triazolo[4,5- t'jpyridinium 3-oxid hexafi uorophosphate (HATU),

tetramethyluronium hexafiuorophosphate (HBTU), or ( l-cyano-2-ethoxy-2- oxoethylidenaminooxy)dimethylamino-morpholi no-carbenium hexafiuorophosphate (COMU) . Activated carboxyiic esters 9-1 may also be prepared from carboxyi ic acids in situ with a phosphonlum salt such as benzotriazol- l-yl-oxytripyrrolidi nophosphoni um hexafiuorophosphate (PyBop) . Activated carboxyiic esters 9-1 may also be prepared from carboxyiic acids in situ with a coupling reagent such as l-(3-dimetbylamino propyl)-3-ethylcarbodiimide, or dicydohexy!carbodiimide in the presence of a triazo!e such as hydroxybenzotriazole- monohydrate (HOBt) or l-hydroxy-7-azabenzotriazole (HOAt) . O-Acylisoureas may be prepared with a dehydrating carbodimlde such as l-(3- dimethy!amino propyi)-3-ethylcarbodli mide or dicyc!ohexylcarbodiimide, Activated carboxyi ic esters 9-1 may also be prepared from carboxyiic acids in situ with a coupling reagent such as 2-chloro- l,3-dimethylimidazolidi nium hexafiuorophosphate (CIP) i n the presence of a triazoie such as l-hydroxy-7-azabenzotriazole (HOAt), Activated carboxyi ic esters 9-i may also be prepared from carboxyiic acids in situ with a coupling reagent such as 2,4,6-tri propyl- l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trloxide (T3P ^® ) i n the presence of a base such as pyridine.

Scheme 9

C ₆ )alkenyl, (C ₂ -C ₆ )alkynyl, or (Ci-C ₆ )haloalkyl, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ^u , R ^iZ , R ¹³ , and R ⁱ⁴ , are as previously disclosed, may be prepared by treatment of iO-1 wherein Q ² is 0, R ¹⁷³ , R ^17b , R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , and R ¹⁴ are as previously disclosed, with an anhydrous acid solution such as hydrochloric acid in 1,4-dioxane and dichioromethane at a temperature of about 25 °C (Scheme 10, step a).

Cyclopropyl amides 10-4, wherein Q ² is O, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , 0 R ^t0 , R ⁿ , R ¹² , R ¹³ , R ¹⁴ , R ^17a , and R ^17b are as previously disclosed, and X ⁵ is substituted or unsubstituted phenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted {Ci-Cs)alkyl, 0(Ci-Cs)alkyl, 0(Ci-Cs)haloalkyi, (C3-C6)cycloalkyl, and

Ofsubstituted and unsubstitutedjphenyl, may be prepared by treatment of cyclopropyl amides 10-2, wherein Q ² is 0, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ^17a , and R ^17b are as previously disclosed, and an activated carboxylic acid or chloroformate 10-3, wherein A is an activating group, and X ^s is disclosed above, with a base, such as triethylamine, diisopropylethyiamine, 4-methylmorpholine, 4- dimethylaminopyridine, or pyridine, in an anhydrous aprotic solvent such as

dichioromethane, tetrahydrofu a , 1,2-dichloroethane, /y,/V-dimethylformamide, or any combination thereof, at temperatures between about 0 °C and about 120 °C (Scheme 10, step b).

Activated carboxylic acids 10-3 may be an acid alide, such as an acid chloride, an acid bromide, or an acid fluoride; a carboxylic ester, such as a p-nitrophenyl ester, a pentafluorophenyl ester, an ethyl (hydroxyimino)cyanoacetate ester, a methyl ester, an ethyl ester, a benzyl ester, an /V-hydroxysuccinimidyl ester, a hydroxybenzotriazol-l-yl ester, or a hydroxypyridyltriazol- l-yl ester; an O-acylisourea ; an acid anhydride; or a thioester. Acid chlorides may be prepared from the corresponding carboxyiic acids by treatment with a dehydrating chlorinating reagent, such as oxalyl chloride or thionyl chloride. Activated carboxyiic esters 10-3 may be prepared from carboxyiic acids in situ with a uronium salt, such as l-[bis(dimethylamino)methylene]- lH- l,2,3-triazolo[4,5- bjpyrldinium 3-oxld hexafl uorophosphate (HATU), 0-(benzotriazol- l-yl)- V _/ /V _/ /V' _/ V ^/ - tetramethyluronium hexafluorophosphate (HBTU), or ( l-cyano-2-ethoxy-2- oxoethyiidenaminooxy)dimethylamino-morphoii no-carbenium hexafluorophosphate (COMU) . Activated carboxyiic esters 10-3 may also be prepared from carboxyiic acids in situ with a phosphonlum salt such as benzotriazol- l-yl-oxytripyrrolidi nophosphoni um hexafluorophosphate (PyBop) . Activated carboxyiic esters 10-3 may also be prepared from carboxyiic acids in situ with a coupling reagent, such as l-(3-dimethylamino propyl)-3-ethylcarbodiimide or dicyclohexylcarbodiimide, in the presence of a triazole such as hydroxybenzotriazole- monohydrate (HOBt) or l-hydroxy-7-azabenzotriazole (HOAt) , O-Acylisoureas may be prepared with a dehydrating carbodlmide such as l-(3- dimethylaminopropyl)-3-ethylcarbodiimide or d!cyciohexyicarbodiim!de. Activated carboxyi ic esters 10-3 may also be prepared from carboxyi ic acids in situ with a coupling reagent such as 2-chloro- l,3-dimethylimidazolidi nium hexafluorophosphate (CIP) i n the presence of a triazo!ol such as l-hydroxy-7-azabenzotriazole (HOAt) , Activated carboxyi ic esters 10-3 may also be prepared from carboxyi ic acids in situ with a coupling reagent such as 2,4,6-tri propyl- l,3,5,2,4,6-trioxatriphosphlnane 2,4,6-trioxlde (T3P ^® ) i n the presence of a base such as pyridine,

Cyciopropyl amides 10-6, wherei n Q ² is 0, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ⁿ , R ¹² , R ¹³ , R ¹⁴ , R ^17a , and R ^17b are as previously disclosed, and X ⁵ is N(R ^17a )(Ci- C ₈ )a!kyl, N(R ^i7a )(Ci~C ₈ )haioaikyi, i(R ^17a )(C3-C ₃ )cyclaalkyi, and N(R ^i7a )(substituted and unsubstituted phenyl), may be prepared by treatment of cyciopropyl amides 10-2, wherei n Q ² Is 0, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ³ , R ⁹ , 0Λ R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ^17a , and R ^17b are as previously disclosed, with an isocyanate or isothiocyanate 10-5, wherein Q ⁴ is 0 or S, respectively, and X ⁵ is as disclosed above, I n an anhydrous solvent such as tetrahydrofuran or ethanoL at temperatures between about 0 °C and about 80°C (Scheme 10, step c) .

Cyciopropyl amides 10-7, wherei n Q ² is 0, R ^17b is H, R ^17c is substituted or unsubstituted heterocydyl, substituted or unsubstituted (Ci-Cs)alkyl, and (C3- C ₆ )cycioaikyl, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , R ⁹ , Q ¹ , R ¹⁰ , R ⁿ , R ^iZ , R ⁱ³ , R ⁱ⁴ , and R ^17a are as previously disclosed, may be prepared by treatment of cyciopropyl amides 10-2 wherei n Q ² is 0, R ¹⁷ Is H, and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ are as previously disclosed, with an aldehyde of ketone, wherein R ^17c is as disclosed above, i n the presence of an acid, such as acetic acid, and a reducing agent, such as sodium cyanoborohydride, in a poiar aprotic solvent, such as ethanoi, at temperatures between about 0 °C and about 80 °C (Scheme 10, step b).

Cyc!opropyi amides 11-3, wherei n Q ² is 0, and R ¹ , R ² _f R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ ,

Q ¹ , R ¹⁰ , R ⁿ , R ¹² , R ¹³ , R ¹⁴ , R ^18a _f R ^i8b _f and R ^18c are as previously disclosed, may be prepared by treatment of hydrazide 11-1 wherei n Q ² is O, and R\ R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , Q ¹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ^18a are as previously disclosed, with aldehydes or ketones 11-2, wherein R ^18b and R ^18c are as previously disclosed, with or without an acid, such as acetic acid, in a polar aprotic solvent such as ethanoi, at temperatures between about 0 °C and about 80 °C (Scheme 18, step a) .

In some embodiments, 1-3 may be prepared from the α,β-unsaturated aldehyde 12-1, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , and R ⁹ are as previously. It will be understood by one ski lled in the art that compound I2-I may be synthesized via Aldoi condensation (see Yoshikawa, M . ; Kamei, T. PCT Int. Appl . 2010123006, 2010) of an appropriately substituted, commercially available aldehyde and acetaldehyde. Treatment of 12-1 with a (Ci-C6)al kyi orthoformate, i n the presence of an acid whose pH Is 0-5 such as

hydrobromic acid, /V~bromosucci ni ide, hydrochloric acid, W-chlorosuccinimide, and pyridini um p-toi uenesulfonate (PPTS), in a (Ci-Cejai kanol solvent, at a temperature from 0 °C to ambient and under ambient pressure provides the acetal 12-2, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , and R ⁹ are as previously disclosed and R ^a is a (G-C6)alkyl or R ³ and R ^a taken together can form a cycl ic acetal (Scheme 12, step a) . The acetal 12-2 may be converted to the cyclopropyl acetal 12-3, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , and R ^a are as previously disclosed, by treatment with a carbene source such as a haloform, for example, bromoform or chloroform, In the presence of an inorganic base, such as sodium or potassium hydroxide or sodi um or potassium carbonate, and a phase-transfer catalyst such as benzyl triethyiammoni um chloride, ( -)-/V-dodecyl-/V-methylephedrini um bromide, tetramethylammonium bromide, tetrapropylammonium bromide,

tetrabutylammonium tetrafiuoroborate, tetramethylammonium chloride or

tetrabutylammonium hexafiuorophosphate at a temperature from about ambient temperature up to below the boiling point of the haloform (Scheme 12, step b). Caution : Step B is an exothermic reaction and careful control of the exotherm should be exercised when conducting this reaction, The cyclopropyl acetal 12-3 may be transformed Into the aldehyde 12-4, wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , and R ⁹ are as previously disclosed, in a polar solvent selected from the group consisting of acetone, acetonitrile, methanol, ethanoi, nitromethane, ^Ai-dlmethylformamide, di methyl sulfoxide, ethyl acetate, tetrahydrofura and 1,4-dloxane, in the presence of an aqueous mineral acid selected from the group consisting of nitric acid, hydrochloric acid, hydrobromic acid, and sulfuric acid (Scheme 12, step c) at ambient temperature. The cyciopropyi acid 1-3, wherein R ¹ , R ⁷ -, R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , and R ⁹ are as previously disclosed, may be obtained by oxidation of the aldehyde 12-4 with oxidants such sodi um permanganate or potassium permanganate, or under Pinnick oxidation conditions in a polar aprotic solvent selected from the group consisting of acetone, acetonitri!e, W,W-di methylformamide, dimethyl sulfoxide, ethyl acetate, tetrahydrofuran and 1,4-dioxane at a temperature from about 0 °C to about ambient temperature (Scheme 12, step d) . Standard safety precautions should be exercised because an exotherm may occur when conducting this reaction.

It will be understood by those skilled In the art that, in some embodi ments, the cyciopropyi acid 1-3, wherein R ¹ , R ^z , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ^s , and R ⁹ are as previously disclosed, may be resolved i nto Its (R,R) and (S _f S) enantiomers via a method such as that in Kova!enko V, N ., Kulinkovich 0, G. Tetrahedron; Asymmetry 2011, 22, 26 (Scheme 13, step a) .

Scheme 13

R1-2B

wherein: X ^R is selected from the group consisting of C1-C4 alkyi or benzyl.

In Scheme Rl, the (±)-trans-racemate of Formula Rl-1 (i.e., the mixture of (R,R) and (S _f S) enantiomers of a trans-2,2-dichloro-3-(substituted phenyl)cyclopropane- carboxyllc acid) is combined with a resolving agent that Is either the enantiomeric amine of Formula R2-1 or Formula R2~2, in a suitable solvent, to provide the diastereomeric amine salts of Formula R3-1A or Formula R3-1B,

R3-1A R3-1E

or of Formula R3-2A or Formula R3-2B,

R3-2A R3-2B

that selectively crystallize or precipitate out of the resulting mixture. The diastereomeric amine salt of Formula R3-1A or Formula R3-1B, or of Formula R3-2A or Formula R3-2B, can then be isolated from the mixture and treated with an acid to provide the (lR,3?)~ or the (lS,3S)-2,2-dihalo-3-(substituted phenyi)cyciopropanecarboxyiic acid of Formula R1-2A or Formula R1-2B, respectively.

Examples

These examples are for illustration purposes and are not to be construed as limiting this disclosure to only the embodiments disclosed in these examples.

Starting materials, reagents, and solvents that were obtained from commercial sources were used without further purification. Anhydrous solvents were purchased as Sure/Seal™ from Aidrlch and were used as received. Melting points were obtained on a Thomas Hoover Unimelt capillary melting point apparatus or an OptiMeit Automated Melting Point System from Stanford Research Systems and are uncorrected. Examples using "room temperature" were conducted in climate controlled laboratories with temperatures ranging from about 20 °C to about 24 °C. Molecules are given their known names, named according to naming programs within ISIS Draw, ChemDraw, or ACD Name Pro. If such programs are unable to name a molecule, such molecule is named using conventional naming rules. ^l NMR spectral data are in ppm (δ) and were recorded at 300, 400, 500, or 600 MHz; ¹³ C NMR spectral data are In ppm (δ) and were recorded at 75, 100, or 150 MHz; and ¹⁹ F NMR spectral data are in ppm (δ) and were recorded at 376 MHz, unless otherwise stated. E ample 1: Preparation of £ran$~2-Ch1orG~5™(2 _f 2-dichlo

dichforopheny!)cycfopropane~l~carboxamido)~/¥~(2~me

trif!uoroacetamido)phenv ^, S)ben2:amsde (FI061)

To a solution of trans~A/~{4-arnino-2-methyiphenyi)-2-chioro-5-(2,2-dlchioro- 3-

(3 _; 4-dich!oroph8ny!)cyciopropan8-l-carboxarnidQ)benzamide (DPI) (0.100 g, 0, 179 mmol) and triethy!amine (0.037 mL, 0.269 mmo!) in dichloromethane (2.0 mL) was added trifluoroacetic anhydride (0.030 mL, 0.215 mmol). The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was directly loaded onto a Ce!lte ^® cartridge. Purification by flash column chromatography using 0-40% ethyl acetate/ hexanes as eluent afforded the title compound as a white solid (0,080 g, 68%), The following compounds were prepared in like manner to the procedure outlined in Example 1 :

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-C3 _? 4-dichlorophenyS)cyc!opropane-I- carboxamsdo)-W-(4-( 2, 2-dif uoroacetamido}-2-methy phenyl )benzamsde (F1062)

Isolated as a white solid (0, 109 g, 95%).

2-ChSoro-5~((ll?,3 l)~2 _f 2~dich!oro~3~{3,4~dichforophenyf )cvclopropane~l~ carbo amido)~i¥~(2 _f 4~difluoro~3~(2 _f 2 _f 2~tnflu >roacetamido)phenv ^, l)benzamide (FI064)

Isolated as a light yellow solid (0.103 g, 89%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf )cvclopropane~l~ carbo¾amido)~i¥~(3~(2 _f 2~d!f uoroacetamid >}~2 _f 4~difSuorophenyS)b8n :am!de

(FI065)

Isolated as a white so!id (0.088 g, 77%) .

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f 4~dichforophenyS)cyclopropane-l~ carbo¾amido)~i¥~(3 _f 5~difluoro~4~(2 _f 2 _f 2~tnflu >roacetamido)phenyl)benzamide

(FI 120)

Isolated as an off-white soiid (0.096 g, 82%) .

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f 4-dich iropheny cyci ipropane-l- carboxamsdc5)-i¥~(4-f!uoro~2~(2 _f 2 _f 2~triffuoroacetamido)phenyf )benzamide

(F1121)

Isolated as an off-white soiid (0.066 g, 58%) . fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f 4~dichforophenyS)cyclopropane-l~ carbo3 amido)~i¥~(2~(2 _f 2~d!f uoroacetamido}~4~fluoroph8nyf )benzamide

(FI 123)

Isolated as an off-white solid (0,0885 g, 74%),

2-Chloro-5-(( l^,3^)-2 _f 2-dschSoro-3-(3 _f 4-dich!oropheny )cycSopropane-i- carboxamsdo)-M-(2 _f 6-d!fiuoro-4-(2 _? 2 _f 2-trif!uoroacetam!do)phenyS)ben¾am!de (F1281)

Isolated as a light yellow foam (0.065 g _f 69%) ,

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 5~dichlorophenyf )cyclopropane~l- carboxamsdo)-i¥~(2 _f 4~diff uoro~3-(2 _f 2,2-triffuoroacetamido)phenyS}~3~ Huorobenzamide (F1330)

Isolated as a white powder (0.068 g, 98%).

2-Ch!oro-S-((l^,3^}-2,2-dschSoro-3-(3 _f S-dichioropheny!)cycSopropane-l- carboxarnsdo)-W-(3-(2 _f 2-d!f uoroacetamido}-2 _i 4-difluorophenyS)-3- fiuorobenzamide (FI333)

Isolated as an off-white powder (0,069 g, 100%),

2~£Η1θΓθ-5~{(1ί?,,3ί?)~2,2~€ϊεΗ!θΓθ~3~(3,4 ,,5~ίΓΪεΗΙθΓο Η8πνΙ}ενεΙο Γο 3ηθ-1~ carbo¾amido)~i¥-(2 _f 4~difluoro~3~(2 _f 2 _f 2~tnflu>roacetamido)phenv ^, l)-3- fluoroberwa ide (F1334)

Isolated as an off-white powder (0,062 g, 100%),

2-ChSoro-5-((l?,3?}-2 _f 2-dschtoro-3-(3,4,5-trichioropheny!)cvciopropane-l- carboMamsdo}-i¥-(3-(2,2-dif!u3roacetamido}-2 _i .4-difluorophenyS}-3- fuorobenzamide (F1335)

Isolated as a light yellow powder (0,057 g, 99%),

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f 4-dich iropheny cyciipropane-l- carboxamsdo)-W~(3 _f S~d!ffuoro~4-(2,2 _? 2-trichSoroacetam!do)phenyf}benz:amide (F1146)

Isolated as an ff-white so!id(0,046 g, 37%).

!orG-5-((lJ?,3i? -2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenvl)cycopropane~l~ fl

Isolated as a light tan foam (0.184 g, 56%),

2-Chloro-5-((l^,3^)-2 _f 2-dschSoro-3-(3 _f 4-dich!oropheny )c¾ ^r cS

amsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 4-dif!uorophenv

ff amide (F1287)

Isolated as a white solid (0,064 g, 90%),

phenyl )cyck

Af-(2,4-difluoro-3-(2,2,2-trifluoroacetamido)phenyl)-3- n

Isolated as a white solid (0,068 g, 93%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~{tnfluoromethyf)pheny!)~ cyclopropane-l-carbo amido)~/¥~(3~(2,2~dsfluoroacetamido)~2 _f 4~ difuoropheny!}-3-fiuorobenzamide (F1289)

Isolated as a white solid (0,065 g, 91%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3-

(tnfuoromethv!)phenv'!)cycSopropane-l-carboxam!do)-W-(2 _f 4-difuoro-3- (2 _f 2 _f 2~trifluoroacetamido)phenyl)-3~fluoroben-iamide (F1290)

Isolated as a white solid (0.068 g, 93%).

2~Chloro~5~((l^ _f 3^}-2,2~dschSoro-3~(3~chforo-4~fSuorophenyS}cycfopro carboxamsd3}-W-(2,4-dif!u3ro-3-(2,2,2-trif!uoroacetamido)phe nv'S}-3- fluorobenzamide (F129I)

Isolated as a white solid (0,062 g, 95%).

Example 2: Preparation of i¥-{3~acetamsdo~2 _f 4~difSuorophe

((l? _J ,3^)~2,2~dichloro~3~(3 _? 4-dichforopheny!)cycfopropane

carbo3amido)b8nzamide (F10S3)

To a solution of /V-(3-amino-2,4-difluorophenyl)-2-chloro-5-((l ?,3 ?)-2,2- dichloro-3-(3,4-dichlorophenyl)cyclopropane-l-carboxamido)be nzamide (DP2) (0,06 g, 0.104 mrnoi) In pyridine (0,30 mL, 3.71 mmol) stirred at room temperature was added acetic anhydride (9,77 μΙ, 0, 104 mmol). The reaction mixture was stirred at room temperature for 18 hours, was quenched with water (3 mL), and was extracted with ethyl acetate (10 mL). The organic layer was washed with hydrochloric acid (1 IM) and brine before being poured through a phase separator. The organic layer was

concentrated under reduced pressure to give a residue. Purification by column ch omatog aphy using 0-30% ethyl acetate/hexanes as eiuent afforded the title compound as a white solid (0.043 g, 67%),

The following compounds were prepared in like manner to the procedure outlined in Example 2 :

2-ChSoro-M-(3-(2-ch!oro-2 _f 2-dsfiuoroacetamido}-2 _f 4-d!f uorophenyS}-S- ((lR _f 3/?)-2,2-dichloro-3-(3,4-dichlorophenyl)cyclopropane-l - carbo5 amido)ben_iamide (F1248)

Isolated as a white solid (0,089 g, 74%).

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cvclopropane-i- carbo5 amido)~i¥-(2,4-difl uoro~3~(2 _f 2 _f 3,3,3- pentaf!uoropropanamido)pheny!)benzamide (F1251)

Isolated as a white solid (0,072 g, 57%).

2~ChSoro-5-{(li? _J ,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf )cyc!opropane~l~ carboxamido)~i¥-(3~(2 _f ~dichSoroacetamido)~2 _f 4~diffuc5rophenyS}benz:arT!sde (F1252)

Isolated as a white solid (0.068 g, 57%). ~(4-Acetamsdo~2 _f 6~difSuorophenyS)~2~chSoro-5-{(ll?,3l?)~2 _f 2~dichforo~3~{3,4- dichforopheny!)cycfopropane~l~carboxamido)benzamide (F1262)

Isolated as a white solid (0,022 g, 26%).

2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo¾amido)~i¥-(4~(2 _f 2~dichSoroacetam!do)~2 _f 6~difuorophenyS)benzamsde (FI272)

Isolated as a white solid (0.028 g, 29%).

2-Chloro-5-((l^,3^)-2 _f 2-dschSoro-3-(3-choTO-4-fluorophenvS}cvclopropane-I- carboxamsdo)-W~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenyl)benzamide (F1234)

Isolated as a white foamy solid (0.083 g, 66%).

2~Chloro~5~((l? _f 3?)-2 _i 2~dschSoro~3~i3 _f 4 _f 5~trichforophenyf)cycfopropane~l~ carboxamsdo)-W~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenyl)benzamide (F1238)

Isolated as an off-white foamy solid (0.090 g, 72%). 2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf )cvclopropane~l~ carbo¾amido)~i¥~(3~(2 _f 2~d!f uoroacetamid >}~2 _f 6~difSuorophenyS)b8n :am!de

(FI240)

Isolated as a white foamy solid (0.100 g, 84%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 5~dichlorophenyf )cycSopropane~l- carboxamsdo)-i¥~(3-(2 _f 2-diffuoroacetamido)~2,6-dif!uorophenvl}benzaniide

(F1241)

Isolated as a white foamy solid (0,086 g, 68%).

2~ChSoro-5-{(li? _J ,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf )cyc!opropane~l~ carbo5 amido)~i¥-(5~(2 _f 2~diffuoroacetarnido}~2 _f 4~difSuorophenyS)ben.iam!de

(F1242)

Isolated as a glassy solid (0.074 g, 59%).

2~Chloro~i¥-(5~(2-chforo~2 _f 2~difluoroacetamido)~2,4-diffuoropheny!)-5~ ((U? _f 3 ?)~2 _f 2~dichSoro-3~{3 _f 4~dichforophenyS}cyclopropane-l~

carbGxamido}benzamide (F1243)

Isolated as a white foamy solid (0,065 g, 49%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf )cvclopropane~l~ carbo¾amido)~i¥-(S~(2 _f 2~dichSoroacetam!do)~2 _f 4~dif uorophenyS)benzamsde

(FI244)

Isolated as an off-white foamy solid (0.035 g, 28%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 4~dichlorophenyf )cycSopropane~l- carboxamsdo)-i¥~(2 _f 4~diff uoro~5-(2 _f 2,2-triffuoroacetamido)phenyS}b8n :am!de (F1245)

Isolated as a white foamy solid (0.080 g, 65%).

i¥-(5~Acetamido-2,4-dif!uorophenyl)-2-chloro~5~{(l^ _f 3^}-2,2~dschforo-3~(3 _f 4~ dichiorophenyS)cvciopropane-l-carboxamido}ben2:amsde (FI246)

Isolated as an off-white foamy solid (0.080 g _f 71%).

fra«s-i¥-(4-Acetamido-3,5-difiuorophenv }-2-chioro-5-(2,2-dich!oro-3-{3,4- dichiorophenyS)cvciopropane-l-carboxamido}ben2:amsde (FI 1 4)

Isolated as an off-white solid (0.042 g, 39%).

frans- f-(2-Acetam!do-4-fluoropheny!)-2-chloro-S-(2 _? 2-d!ch!oro-3-(3 _f 4- dich!oropheny cyciopropane-i-carboxa!T!ido)ben2:amsde (FI 125)

Isolated as an off-white solid (0.039 g, 33%) ,

■2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f 4~dichforophc !)cydopropane-l- en O enzamidc

Isolated as a l ight yellow solid (0.078 g, 59%) .

Example 3; Preparation of 2~ch!oro~S~({ l^ _f 3^)-2 _? 2-dichforo~3~(4-f!uoro~3~ (triffuoromethy! )phenvf )cycSopropane~l~carboxamido)~M~(2 _f 4~diff uoro~3~ (2 _f 2 _f 2~trifluoroacetamido)phenvl)ben2amide (F 1169)

Trifluoroacetic anhydride (0.035 g, 0.251 mmol) was added dropwise to a stirred sol ution of /V-(3-amino-2,4-difluorophenyl)-2-chloro-5-(( l ¾,3 ?)-2,2-dichloro-3-(4-fluoro- 3-(trifluoromethyl)phenyl)cyclopropane-l-carboxamido)benzami de (DP9) (0.100 g, 168 mmol), and triethyiamine (0.051 g, 0.503 mmol) in anhydrous dichloromethane (3 mL) , The sol ution was stirred for 12 hours at 23 °C and concentrated . Purification by silica gel flash chromatography gave the title compound as a white foam (0.084 g, 69%) .

The following compounds were prepared in like manner to the procedure outlined in Example 3 :

2~ChSoro-W~(3-(2~chloro-2 _J ,2~dsffuoroacetarnido)~2 _f 4~diffuorophenyS }~S~

(( lW,3J?)~2 _f 2-dichloro~3~{4-fSuoro~3~(triffuoromethyf )phenv ^, l)cyc opropane~l~ carbo3camidG)benzar

Isolated as a white solid (0,089 g, 71%).

2-€ΗΙθΓθ-5-{(Ιί?,.3ί?)- ,,2-«^ίεΗ!θΓθ-3-(4-ΐΙυο!Ό-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(3~ (2 _f 2~

dichforoacetamido)~2 _? 4-dif!uorophenyl)benzamide (F1174)

Isolated as a white foam (0.058 g, 46%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l-carbo3 amido)~ ¥~(3~(2 _f 2~

diff uoroac8tamsdo)-2,4~dsfluoroph8nyf }benzamide (F1175)

Isolated as a white solid (0.283 g, 70%).

i¥~(3~Ben¾amido~2 _f 4~difSuorophenyf )~2~chloro~5~((l l,3J?)~2 _f 2-dichloro~3~{4- ffuoro~3~(trifSuoromethyl)ph8nyf )cycSopropane~l~carbo amido)benzamid8 (FI 179)

Isolated as a white foam (0.015 g, 12%).

J¥~(3~(2~Bromo~2,2-dif!uoroacetamsdo)-2,4~difluorophenyf )~2-chforo~S~ ((lR,3/?}-2,2-dich!oro-3-{4-fSuoro-3-(trif!u 3romethy )pheny!}cyc!opropane-l- carboMamsdo}benzamide (FI276)

Isolated as a white solid (0,078 g, 59%).

frans~2~Chforo~5~(2 _f 2~dichSoro-3~{3 _f 5~dichfc5ro~4-f!uorophenyl)cycfopropane~l~ carbo5amido)~i¥-(3~(2 _f 2~diffuoroacetarnido}~2 _f 4~difSuorophenyS)ben.iam!de (F1331)

Isolated as a white foam (0.037 g, 62%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-(3 _f S-dich oro-4-fluorophenyS}cvclopropane-I- carboxamsdo)-M-(2 _f 4-d!fiuoro-3-(2 _? 2 _f 2-trif!uoroacetam!do)phenyS)ben¾am!de ^ IF ]L 1.£ ^

Isolated as a white solid (0.031 g, 51%).

Example 4; Preparation of ferf-butyS (4~({3~{2~chSoro~5-((ll?,3l?)~2 _f 2~dichforo~ 3-{3,4-dichlorophenyt)cyc!opropane-I-carboxamsdo)benxar!iido }-2,6- dif!uorophenyS}amsn j)-4-OM 3buty!}carbamate (F1199)

To a solution of /V-(3-amino-2,4-difluorophenyl)-2-chloro-5-((l?,3?)-2,2- dichloro-3-(3,4-dichlorophenyl)cyclopropane-l-carboxamido)be nzamide {DPI} (0.100 g _f 0.173 mmol) in ethyl acetate (2 mL) stirred at room temperature were added 4-((£erf~ butoxycarbonyi)amino)butanoic acid (0.035 g, 0.173 mmol) and pyridine (0,028 mL, 0.345 mmol). 2,4,6-Tripropyl-l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P®; 165 mg, 0.259 mmoi) was added a 50% solution in ethyl acetate. The reaction mixture was warmed to 50 °C for 18 hours then cooled to room temperature and concentrated under a stream of nitrogen. Purification by column chromatog aphy using 0-80% ethyl acetate/hexanes as ei uent afforded the title compound as a white solid (0, 111 g, 84%) .

The following compounds were prepared In like manner to the procedure outlined in Example 4 :

frans~ferf~But¾fl (4~({4~(2~ch!oro~S~(2,2-dichforo~3~{3 _i 4~dichSorophenvl )- cycfopropane~l~carboxamido)ben2amido)~3~m8thySphenvl)amino)~ 4~ oxGbuty!}carbamate (F1200)

Isolated as a white sol id (0.097 g, 72%) ,

2-Ch!oro-S-(( l^,3^}-2,2-dschSoro-3-(3 _f 4-dichioropheny! )cvcSopropane-l- carboxamsdo)-W-(3-(2 _f 2-d!f uoropropanamWo)-2 _f 4-d!fiuoropheny )benz:a!T!ide (F1249)

Isolated as a white sol id (0.097 g, 83%) .

M-(3- enzam!do-2,4-difSuorophen¾f|)-2-ch!oro-S-{ ( ii? _f 3 ₁ )-2 _? 2-d!chloro-3-{3 _i .4- dichforopheny!)cycfopropane~l~carboxamido)benzamide (F 1 53)

Isolated as a l ight brown solid (0,076 g, 64%) ,

Example 5: Preparation of £ ^, rans-W-(3-acetamido-2-chloro-4-f!uoropheny }-2- chloro-5-{2 _f 2-dsch oro-3-(3 _f 5-d!chSoropheny )cycSopropane-i- carbo5 amido)ben_iamide (F1160)

2,4,6-Tripropyl-l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P ^® , 50% solution in ethyl acetate; 0,281 g, 0.441 mmol) was added dropwise to a stirred solution of trans-2-chloro-5-(2,2-dichioro-3-(3,5-dichlorophenyl)cyciopr opane-l- carboxamido benzoic acid (C12) (0.100 g, 220 mmol), W-(3-amino-2-chloro-6- fluorophenyl)acetamide (C194) (0.048 g, 0,220 mmol), and pyridine (0,053 g, 0.661 mmoi) in anhydrous ethyl acetate (3 mL), The solution was stirred for 12 hours at 23 °C and concentrated. Purification by silica gel flash chromatography gave the title compound as a white foam (0, 105 g, 71%),

The following compounds were prepared In like manner to the procedure outlined in Example 5:

J¥-(3-Acetamsdo-2-chtoro-4-ftuorophenv!}-2-ch!oro-S-((l^ _f 3i?}-2,2-dschSoro-3-

(4-f uoro-3-(trifluoromethy!}pheny!}cycSopropane-I-carb 3xamido)benzamsde

(F1161 )

Isolated as a white foam (0.052 g, 71%),

Example 6: Preparation of 2-chSoro-5-((I ? _i .3 ?}-2 _i 2-dichloro-3-(4-fluoro-3- (tnfluoromethyS}phenv!)cvc!opropane-I-carboxamido)- f-(2 _? 4-difluoro-3-(4- ffuorobeniarnido}phenyl)ben_iam!de (F1204)

2,4,6-Tnpropyl-l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P ^® , 50% solution in ethyl acetate; 0,213 g, 0.335 mmol) was added dropwise to a stirred solution of A/-(3-amino-2,4-difluorophenyl)-2-chloro-5-((l ?,3 ¾)-2,2-dichloro-3-(4-fluoro-3- (trifluoromethyl)phenyl)cyclopropane-l-carboxamido)benzarnid e (DP9) (0.100 g, 0.168 mmoi), 4-fiuorobenzoic acid (0,028 g, 0.201 mmoi), and pyridine (0.040 g, 0,503 mmoi) in anhydrous ethyl acetate (3 mL), The solution was stirred for 12 hours at 50 °C and concentrated. Purification by silica gei flash chromatography gave the title compound as a white foam (0.029 g, 23%).

The following compounds were prepared in like manner to the procedure outlined in Example 6:

2-€ΗΙθΓθ-5-(( 1^,3^)-2,2-€ίεΗ§θΓθ-3-(4-ΑυοΓθ-3-

(tnf uoromethv!)pheny!)cycSopropane-l-carboxam!do)-W-(2 _f 4-dif uoro-3-(4- methoxybeniamido)phenyl)ben-iarnide (F1205)

Isolated as a white so!id (0.020 g, 16%).

W-{3-(2-Chloro-S-((i^ _f 3^)-2 _? 2-d!chloro-3-(4-f!uoro-3

(triffuoromethy!)phen¥f )cycSopropane~l~carboxamido

difluoropheny! Nicotinamide (F1206)

Isolated as a white solid (0.041 g, 33%).

i¥-{3~Acetamido-2,4-dif!uorophenyl)-2-chloro~S~({l^ _f 3 ?)-2 _i 2~dschforo~3~i4~ f uoro~3~(trif!uoromethyS)phenyl)cyclopropane~l~carboxamido)be nzamide (F1231)

Isolated as a white solid (0.029 g, 26%).

i¥-(3~(2-Chforo~5-((lJ? _f 3J?)-2,2-dichloro~3~(4-f!uoro~3~

(triffuoromethy!)phenyf }cycSopropane-l~carboxamido}benzamido)-2,6~ dif!uorophenyS)-6-f!uoronic 3t!namide (FI258)

Isolated as a white solid (0.019 g, 15%).

2-ChSoro-i¥~(3-(l~cyanocycSopropane~l~carboxam!do)~2 _f 4~d!ffuorophenyf)~S~ ((lR,3/?}-2,2-dich!oro-3-{4-fSuoro-3-(trif!u3romethy)pheny!} cyc!opropane-l- carboMamsdo)benzamide (FI263)

Isolated as a white foam (0.078 g, 64%).

2-ChSoro-W-(3-(cyc!opropanecarboxamido}-2,4-dsffuoropheny!}- 5-((lR,3W}-2 _f - dich!oro-3-{4-f uoro-3-(trifluoromethyS}phen¾f!)cvclopropane-i- carboxamsdo)ben2:am!de (FI264)

Isolated as a white foam (0.100 g, 85%).

2-Chloro-W-(3-(2 _f 2-d!chSoro-i-methy!cycSopropane-I-carboxam!do)-2 _f 4- diffuorophenyS)~S~((l ? _f 3l?)-2 _i 2~dschSoro~3~i4~f!uoro-3~

(triffuoromethy!)phenyf)cycSopropane~l~carboxamido)benzamide (F1273)

Isolated as a white solid (0.078 g, 30%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3-

(trif!ujromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-( 2 _f 4-dif!uoro-3- piva amidopheny!)benzam!de (F1274)

Isolated as a white solid (0.014 g, 12%) 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l-carbo3amido)~¥~(3 ~(2 _f 2~

dif uorocyc!opropane-I-carboxamido}-2,4-dif uorophenv!)benxar!iide (F127S)

Isolated as a white solid (0.135 g, 73%).

2-ChSoro-W-(3-(c¥c!ohex-3-ene-l-carboxariiido)-2,4-difiuoro pheny )-5- ((lR,3/?}-2,2-dich!oro-3-{4-fSuoro-3-(trif!u3romethy)phenv!} cyc!opropane-l- carboxamsdo)ben2:am!de (FI297)

Isolated as a white solid (0,119 g, 96%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3-

(tnf uoromethy!)phenv'!)cycSopropane-l-carboxam!do)-W-(2 _f 4-dif uoro-3-(2- oxo~2~phenyfacetamido)pheny!)benzamide (F1298)

Isolated as a clear colorless oil (0.087 g, 68%).

2~Chloro~5~((l ? _f 3l?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phen¥f)cycSopropane~l~carboxamido)~M~(2 _f 4~diffuoro~3~(2~ (methyfsuffonyl)acetamido)phenyS)benz:amsde (F1299)

Isolated as a white foam (0.111 g, 88%). ~(3-(2~Chforo~S~({l _f 3 )~2 _f 2~dichSoro-3-(4~ffuoro-3- (triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)ben¾amid o)~2 _f 6~

Isolated as a white solid (0.085 g, 70%).

2-ChSoro-5-((l ?,3?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnfuorom8thvOphenyi}cvcfopropan8-l-carboxamido}-/y-(2,4- dif uoro-3- (2 _f 2 _f 3,3-tetraf!uoropropana!T!ido)phenv'!)ben2:amide (FI301)

Isolated as a white foam (0.103 g, 81%).

W-(3-(2-Ch!oro-5-((I#?,3^)-2,2-dichSoro-3-(4-f!uoro-3- (tnf uoromethy!)phenv ^, !)cycSopropane-l-carboxam!do)ben2:a!T!!do)-2 _? 6- dif uorophenyS)-S-methySthsophene-2-carboxa!T!!de (FI302)

Isolated as a white solid (0.035 g, 28%).

2~Chloro~5~((l ? _f 3?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf}cycSopropane-l~carboxamido}~ ~(2 _f 4~dif uoro~3~{3~

!ido)phenyl)ben¾ar

Isolated as a white solid (0.093 g, 76%). E ample 7: Preparation of £ ^, rans~ ~(4~Acetamido~2~methySphenvl)~2-ch!oro~5~

(2 _f 2~dich!oro~3~{3,4~dichforopheny!)cycf >propane~l~carboxamsdo)benzamide

(FI059)

To a solution of frans-/V-(4-amino-2-methylphenyl)-2-chloro-5-(2,2-dichloro-3 -

(3,4-dichlorophenyl)cyclopropane- l-carboxamido)benzamide {DPI} (0.100 g, 0, 179 mmol) and triethylamine (0.037 mL, 0.269 mmol) in dichloromethane (2.0 mL) was added acetyi chloride (0.015 g, 0, 197 mmol) . The reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was diluted with ethyl acetate and washed with hydrochloric acid (1 N ; 2x) and brine. Celite ^® was added to the organic Iayer, and the mixture was concentrated under reduced pressure. Purification by flash col umn chromatography usi ng 0-40% ethyl acetate/hexanes as ei uent afforded the title compound as an off-white solid (0,079 g, 73%) ,

The following compounds were prepared in like manner to the procedure outlined in Example 7:

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f 4-dich iropheny cyci ipropane-l- carboxamsdo)-M-(2-methv!-4-{2 _f 2 _f 2-tnchloroacetamido)phenv!)ben¾amide

(F1080)

Isolated as a white sol id (0.060 g, 47%) .

2~Chloro~5~((l ? _f 3 ?)-2 _J ,2~dschSoro~3~(3 _f 4~dichlorophenyf }cycSopropane~l~ carboxamsdo}- ~(2 _f 4~diff uoro~3-(2 _f 2,2-trichSoroacetamido)phenyf )benzamid8

(F1063)

Isolated as a white sol id (0.039 g, 34%) . 2-Ch!orQ-5-(ilJ?,3J?)~2 _f 2~dich! 3~{3,4~dichforophenyf)cyclopropane~l~ carbo3amido)~i¥~(2 _f 4~difluoro (2~rnetho yacetamido)phenyf)benzamide

Isolated as a white solid (0,072 g, 64%).

mpfe 8: Preparation of 2~chSoro~5~((l ,3l?}~2 _f 2~dichforo~

luoromethvOphenyi}cvcfopropane-l-carboxar!iido}-/y-(2,

thyisufonv'S}methy!su!fonamsd 3}pheriy!)benzamide (F1

Methanesulfonyi chloride (0,029 g, 0,251 mmol) was added dropwise to a stirred solution of A-(3-arr5ino-2,4-difluQrophenyi)-2-chloro-5-((lj _f 3iR)-2,2-d!Chloro-3-(4-fiuoro- 3-(trifluoromethyl)phenyl)cyclopropane-l-carboxamido)benzami de (DP9) (0,100 g, 168 mmol) and triethylamlne (0.051 g.0,503 mmol) in anhydrous dich!oromethane (3 mL), The solution was stirred for 12 hours at 23 °C and concentrated. Purification by silica gel flash chromatography gave the title compound as a white foam (0,044 g _f 33%),

Example 9: Preparation of 2-chtoro-5-((IW _f 3W}-2,2-dichloro-3-(4-fluoro-3- (tnfluoromethyS}phenv!)cvc!opropane-I-carboxamido)- f-(2 _? 4-difluoro-3- (phenyisuffonamsdG)phenyf}benz:a ide (F1295)

Benzenesulfonyl chloride (0.044 g, 0,251 mmol) was added to a stirred solution of A-(3-amino-2,4-difluorophenyl)-2-chioro-5-((l? _f 3R)-2 _i 2-dichioro-3-(4-fluoro-3- (trifluoromethyl)phenyl)cyc!opropane-l-carboxamido)benzamide (DP9) (0,100 g, 168 mmol) in acetonltrile (3 mL), The solution was stirred for 36 hours at 70 °C and concentrated. Purification by silica gel flash chromatography provided the title compound as a pink solid (0.112 g, 86%). E ample 10; Preparation of frans~2~chSoro~i¥~(4~((4~chforobenzyS)amino)~2- niethv ^, lphenyS}~5~(2,2~dschfor >-3~(3 _f 5~dichSoroph8nvf )cycSopropane-l~

carbo3 amsdo)ber!2:amide (FIOIO)

4-Ch!orobenza!dehyde (0,0252 g, 0.179 mmo!) was added to a stirred suspension of trans-/V-(4-amino-2-methyl phenyl)-2-chloro-5-(2,2-dichloro-3-(3,5- dich!oropheny!)cyc!opropane- l-carboxamido)benzamide (DP4) (0.100 g, 0.179 mmo!) and sodium acetate (29.4 mg, 0.359 mmol) in methanol (20 mL), water ( 15 mL) and acetic acid (3 mL) . The resulting heterogeneous mixture was stirred at 25 °C for 3 hours. Sodi um cyanoborohydride (0.0158 g, 0, 251 mmol) was added in one portion. The resulting colorless solution was stirred at ambient temperature for another 4 hours. The reaction mixture was quenched with water (50 mL) and extracted with diethyl ether (3 x 50 mL) . The organic extracts were washed successively with water and saturated aqueous sodi um chloride solution, dried over anhydrous magnesium sulfate, and concentrated under vacuum on a rotary evaporator. Purification by silica gel flash chromatography provided the title compound as a yellow foam (0.087 g, 68%) .

The following compounds were prepared in like manner to the procedure outlined in Example 10:

frans-2-Chloro-S-(2 _? 2-d!chlo!O-3-{3 _f S-dich iropheny cyci ipropane-l- carboxamsdo)-M-(4-( {4-methoxybenzy }amino)-2-meth¾f|pheny }benz:amide

(F1035

Isolated as a yellow foam (0.095 g, 74%),

trans~2~Chforo~M~(4~((4~cyanoben2yS )amsno)~2~methyl phenyl )~5~(2,2~dschSoro- 3-{3,5-dichlorophenyt)cyc!opropane-I-carboxamsdo)benxar!iide (F1040)

Isolated as a yellow solid (0.097 g, 76%).

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS)cyci 3propane-l- carboxamsdo)-M-(2-methv!-4-({4-methvSbenzyS)amsno)pheny)benz :a!T!ide (Fi041)

Isolated as a yellow solid (0.081 g, 65%).

frans~2~Chforo~5~(2 _f 2~dichSoro-3~(4~ffuoro-3-

(triffuorom8thyS}phenyl)cyc!opr>pane~l-carb>3amido) ~¥~{2,4~diffuor>-3~({4- nietho3ybenzyl)amino)phenyf)benzamide (F1096)

Isolated as a white foam (0.059 g, 47%).

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cycloprop

carbo3amido)~i¥~(2~methy 4-{(4~

(trifuoromethoxy)ben2:y!}amsno}pheny)benzamide (Fill?)

Isolated as a yeiiow solid (0.113 g, 82%). fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane-l~ carbo¾amido)~i¥~(2~methy 4-{(4~nitrob8n :yf }ani!no)pheny!)benzamide

(FI 166)

Isolated as a yellow oil (0.076 g, 77%).

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS)cyci 3propane-l- carboMamsdo}-i¥-(2-methyi-4-({4-

(trif uoromethy!)ben2:y!)ammo}phenyS)ben¾amide (Fi lSS)

Isolated as a pale yellow foam (0.039 g, 42%).

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS)cyci 3propane-l- carboxamsdo)- f-(2-!T!ethy!-4-{phenethySa!Ti ino}pheny!)benza!Ti!de (FII77)

Isolated as a pa!e yellow foam (0.025 g _f 27%)

■2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3ropheny l)cych

carboMamsdo}-i¥-(2-methyi-4-({2-phenyS propyl }ami no) phenyl )b«

(FiI78)

Isolated as a pale yellow foam (0.055 g, 58%).

2~Chloro~5~((l ? _f 3l?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf}cycSopropane-l~carboxamido}~ ~(2 _f 4~diffuoro~3~{{4~ nitrobenzyl)amino)phenyl}b8nz:amsde (F1296)

Isolated as a yellow oil (0.008 g, 4%).

Example 11: Preparation of trans-2-chloro-5-(2 _? 2-dschloro-3- dichforopheny!)cycfopropane~l~carboxamido)~/¥~(4~ffuoro~3~

vinyfphenyf)ben-iamide (F1311)

To a solution of trans-V-(3-bromo-4-fluorophenyl)-2-chloro-5-(2,2-dichloro-2 (3,5-dic lorophenyl)cyclopropane-l-carboxamido)benzamide (FI304) (0,4 g, 0,64 mmo!) In 1,4-dioxane (7 mL) degassed with argon were added tri butylvi nylti n (0.26 mL, 0.89 mmoi) and bis(triphenylphosphine)palladium(II) dichioride (0.044 g, 0.064 mmol) , and the reaction mixture was irradiated in a microwave at 90 °C for Ihours, The reaction mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate (2 x 10 mL) . The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by column chromatography using 15-20% ethyl acetate/petroleum ether as eluent afforded the title compound as an off- white solid (0. 11 g, 40%) .

The following compounds were prepared In like manner to the procedure outlined in Example 11 :

frans-l-Ch oro-B-il _f Z-d!ch!oro-S-CS^B-dich!oropheny cyc!opropane-I- carboxamsdo)-W- -f uoro-2-vinyS phenyl! )benzamsde (F1312)

Isolated as an off-white solid (0.12 g, 44%) .

frans~2~Chforo~5~(2 _f 2~dichSoro-3~{3 _f 5~dichforophenyS}cyclopro

carbo3 amido)~i¥~(2~fSuoro~4~vinySpheny!)ben2amide (F1313)

Isolated as an off-white solid (0.07 g, 26%) . fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane- carbo3amido)~i¥~(2 _f 4~difluoro~S~vinyf henyl )benzamide (F1315)

Isolated as an off-white solid (0,13 g, 48%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f S-dich iropheny cyciipropane- cam sdo)- f-(2 _f 4-d!fiuoro-6-viny henyl )benzamide (FI3I6)

Isolated as an off-white solid (0.12 g, 44%).

-2~Chforo~5-(2,2-dichloro~3~{3,5-dichforopheny!)cycfopropane carboxamsdo)-i¥~(3 _f 4~diffuoro~5-vinyf phenyl )benzamide (F1317)

Isolated as an off-white solid (0.10 g, 37%).

^■ 2-Ch oro-5-(2 _f 2-d!chSoro-3-C3 _? 5-dichlorophenyS)cyc!opropane- carboxarru

Isolated as an off-white solid (0.15 g, 55%).

-2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane- rbo3amido)~i¥~(4~fSuoro~2~{l~fSuorovinyf)phenyS}benz:am!de (F13.

Isolated as an off-white solid (0.17 g, 70%).

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS)cyci

carbo3 amsdo)-i¥-(2-fluoro-4-( I-fluoroviny!)phenyS}ben2:amid

Isolated as an off-white solid (0.15 g, 62%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f S-dich iropheny cyci ipropane- carboxamsdo)-i¥~(2 _f 4~diff uc5ro~3-(l~ff uorovinyf )phenyS}benz:arT!ide (Ϊ

Isolated as an off-white solid (0.12 g, 63%).

■2-Ch oro-5-(2,2-d!ch!oro-3-{3,5-dichk t)cyd

carboxamsd j}-W-(2,4-dif!u 3ro-6-(l-f!uoroviny!)phc

Isolated as an off-white solid (0.09 g, 50%).

2~Chforo~5~(2 _f 2~dichSoro-3~{3 _f 5~dichforophenyS}cyclopropane-l- ca amido)~i¥-(3,4~difluoro~5~(l~ff uorovinyl)pheny!)beniamide (Fl.

Isolated as an off-white solid (0.11 g, 58%).

Example 12: Preparation of tra«s-2~chloro~5~{2,2-dschforo-3~(3 _f 5~

dichiorophenyS)cvciopropane-l-carboKamido}-/¥-(4-{(2-hyd roxvethyt)amino}- 2-methySphenyt)benxamsde (F1130)

4 M Hydrogen chloride in 1,4-dioxane (0.370 mL, 1.479 mmol) was added dropwise to a stirred solution of trans-2-((feri-butoxycarbonyl)(4-(2-chloro-5-(2,2- dichloro-3-(3,5-dichlorophenyl)cyclopropane-l-carboxamido)be nzamido)-3- methylpheny!)ammo)ethyl acetate (F1129) (0, 110 g, 0.148 mmol) in dichloromethane (5 mL). The resulting suspension of solid was stirred for 12 hours at 23 °C and then quenched with saturated aqueous sodium bicarbonate (5 mL), The aqueous mixture was extracted with ethyl acetate (3 x 5 mL) and the organic extract was washed with saturated aqueous sodium chloride solution (5 mL) and concentrated under vacuum on a rotary evaporator. Purification by silica gel flash chromatography gave the title

compound as a pale yellow foam (0,050 g, 53%).

The following compounds were prepared in like manner to the procedure outlined in Exampie 12:

2~{(4~(2-Chforo~5-((lW _f 3J?)~2 _f 2-dichloro~3~{4-fSuoro~3~

(triffuoromethv!)phenvf }cycSopropane-l~carboxamido)benzamido)-3~ methylpheny!)amsno}ethy! acetate (FI144)

Isolated as a clear colorless oil (0,043 g, 31%), 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)~¥~{4 ~({2~

hydroxyethyi)aminG)-2- ethyf phenyl )benzamide (F1I45)

Isolated as a pale yellow foam (0.040 g, 31%),

trans~N~(4~{{3~ Am ino~3~03opropyl)amino)~2~ni ethyl phenyl )~2~chloro~5~(2 _f 2~ dichioro-3-(3,5-dichtorophenyS)cycopropane-l-carboxamido}ben zamide (F1I58)

Isolated as a grey solid (0.013 g, 16%).

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-C3 _? 5-dichlorophenyS)cyc!opropane-I- carbo5amido)~i¥-(4~((2~rnetho5yethyl)amino)~2-methyf phenyl )ben_iarnide (F1162)

Isolated as a pale yellow foam (0.062 g _f 86%).

Example 13: Preparation of f-(3-amlno-2,4-diflu3rophenyS)-2-chSoro-5- ((lR,3l?}-2,2-dichloro-3-{3-chtoro-4-fluoropher!yl}cycSoprop ane-l- carboxamsdo)-3-fluorobenzam!de (F125S)

To a solution of tert-butyl-/V-tert-butoxycarbonyl- v-[3-[[2-chloro-5-[[( l ¾,3 ?)- 2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-carbony l ]amino]-3- fluorobenzoyl]amino]-2,6-difluorophenyl]carbamate (F 1239) (0.166 g, 0, 21 mmoi) In dioxane ( 1 mL) was added a 4 molar sol ution of hydrogen chloride i n dioxane (0.53 mL, 2. 12 mmoi), and the colorless solution was stirred at room temperature for 16 hours. The light-yellow solution was concentrated and the residue was partitioned between ethyl acetate (5 mL) and saturated aqueous sodium bicarbonate (5 mL) . The phases were separated and the aqueous phase was extracted with additional ethyl acetate (2 x 2.5 mL) , The combined organic extracts were washed with bri ne (3 mL), dried over sodium sulfate, filtered, and concentrated to an amber residue. The residue was dissolved in minimal ethyl acetate and adsorbed to Celite ^® . Purification by automated flash chromatography using a gradient of 0-40% ethyl acetate in hexanes as eluent provided the title compound as a white sol id (0, 111 g, 88%) .

The following compounds were prepared in iike manner to the procedure outlined in Example 13:

i¥~(3~Amino-2,4~diffuorophenv!)~5~{2 _f 2~dichloro~3~(3~chloro~4~

ffuorophenv!)cycfopropane~l~carboxam sdo)-2-fluoro~3~m8thyS benzam ide

(F1151 ):

Isolated as a white sol id (0,056 g, 74%) .

W-{3-(4-Aminobutanam!do)-2 _f 4-d!f uorophenyS}-2-chSoro-5-(( I ? _i .3 ?}-2 _i 2- dichloro~3~{3 _f 4~dich!orophenyS}cycfopropane~l-carbo3camido)ben-iamid e

(F1201 )

Isolated as a white foam (0.077 g, 81%) .

frans-W-(4-(4-Am!nobutanamido)-2-methv!phenyS)-2-ch oro-5-(2 _f 2-d!ch!oro-3- (3 _f 4~dichSorophenyl )cycSopropane~l~carboxamido)benzamide (F 1202)

Isolated as a white solid (0,035 g, 42%).

W-{3-Amino-2 _f 6-dif uorophenyS)-2-ch oro-5-((i ? _? 3 ?}-2 _f 2-dich!oro-3-{3 _? S- dich!oropheny cyc!opropane-l-carboxamidolbenxamsde (F1227)

Isolated as a brown foamy solid (0.225 g, 95%).

i¥-(3~Amino~2 _f 6~dif uorophenyS)~2~chfor >-5~({ l ,3l?}~2 _f 2~dichloro~3~(3 _f 4,5~ trichtorophenyS}cycfopropane-l-carboxamido)benzamide (FI228)

Isolated as an off-white foam (0.216 g, 97%),

M-(3-Amino-2 _? 6-d!fluoropheny -2-chloro-S-(C i^ _f 3^)-2 _? 2-dich!oro-3-(3-ch!oro- 4~fluorophenyf )cyc!opropane~l~carboxamido)benzamide (F1247)

Isolated as a white foamy solid (0, 195 g, 92%).

W~{3-Amino~2,6-difluoropheny!)-2~chforo~S~((J^3^)-2,2-dic hforo~3~{3 _f 4~ dichforopheny!)cycfopropane~l~carboxamido)benzamide (F1250)

Isolated as a white foamy solid (0,225 g, 97%).

M-(3-Amino-2 _? 4-d!fluorophenv -2-chloro-S-(C i^ _f 3^)-2 _? 2-dich!oro-3-(3 _f 4- dichforopheny!)cycfopropane~l~carboxamido)~/¥~methySbenzami de (F1056)

Isolated as a beige foam (0.1 g, 85%).

frans~M~(3~Amsno~2 _f 4~difSuoropheny!)~2~ch!oro-5-{3~(3 _i S~dschSorophenyl)-2 _i 2~ diff uorocycfopropane~l~carboxamido)ben2amide (F10SO)

Isolated as a light yellow solid (0.195 g, 75%).

i¥-(3~Amino~2 _f 4~dif uorophenyS)~2~chfor >-5~({ l ,3l?}~2 _f 2~dichloro~3-(3 _f 4,5- trich!orophenyS)cyc!opropan8~l~carbo3 amido)~3~f uorobenzamid8 (F1325)

Isolated as an off-white solid (0,130 g, 46%),

W-{3-Amino-2 _f 6-difuorophenyS)-2-ch oro-5-((i ? _? 3 ?}-2 _f 2-dich!oro-3-{3 _? S- dich!oropheny cyc!opropane-i-carboxamidol-S-fiuorobenzamide (FI336)

Isolated as a tan powder (0,160 g, 81%),

frais~M~(3~Arnino-2 _? 4~dsf!uorophenyf)-2 _f 6~dichSoro~3~(2 _f 2~dichloro~3~{3~ chSoro-4~fluoropheny!)cycfopropane~l~carboxamido)benzamide (F1110)

Isolated as a tan solid (0.044 g, 80%),

frans~i¥~(4~Amsno~3 _f 5~difSuorophenyl)~2~chloro-5~{2 _f 2~dich!o

dichforopheny!)cycfopropane~l~carboxamido)ben2amide (DP

Isolated as a !ight brown foam (1,59 g, 93%).

fra«s~ ¥~{3~Amsno~2 _f 4~difSuorophenyl)~S~(2 _f 2~dichSoro~3~{3~chSor >

f uorophenyt)cyc!opropane-I-carboxamsd j}-2-fiuoro-3-methyS e

Isolated as a white so!id (0.056 g, 74%).

frans-W-(3-Ammo-2 _f 4-dsfluoropheny!)-2-ch!oro (2 _f 2-dlchloro-3-(3-chloro-4- fluorophenyl }cydopropane-l-carboxamido}~3 enzar

Isolated as a tan solid (0.100 g, 86%).

trans~ ~(3~Amino-2,4~dsfluoroph8nyf )-2-chforo~5~(2,2~dschSoro~3~(3~chfor >-4~ ienyS)cyci jpropane-l-carboMamsdo}-3-

Isolated as a tan solid (0.054 g, 46%).

frans-M-(3-Ammo-2 _? 4-dsfSuoropheny!)-3-ch!oro-5-{2,2-dsch!oro-3-(3-chloro -4- fluoropheny!)cycfopropane~l~carbQxamldo)-2™methy!benzamide (F1 23)

Isolated as a tan foam (0.052 g, 46%),

fraiis~ ¥~(3~Amsno~2 _f 4~difSuorophenyl)~2~chloro~5~(2 _f 2~dich!oro~3

^)cvc!opropane-I-carboxamsd j}-3-ftrifi

Isolated as a white solid (0.052 g, 83%).

frans~i¥~(3~Amsno~2 _f 4~difSuoropheny!)~5~{2 dichSoro~3~(3~chSoro~ phenyl }cycfopropan8~l~carbo3 amido)~3~f ^■ l-methoxybenzamk

Isolated as a white solid (0.053 g, 81%).

-Amino-2,4-dif uorophenyt)-2-ch oro-5- (fDcyc!opropane-l-carboxamid! ^■ 3-fl

Isolated as a white solid (0.193 g, 91%). ~(3-Amino-2,4-diffuor>phenv ^, !)-2~chforo~S~{{lJ? _f 3^)-2,2-dichforo~3~(4-ffuor>- 3-{tnfluoromethyf)phenyS}cycfopropane~l~carbo3amido)~3~ffuor obenzamide

Isolated as a white solid (0,208 g, 93%).

frans-W-(3-Ammo-2 _f 4-dsfluoriphenv!)-S-{2 _? 2-dich!oro-3-{3-ch!oro-4- fuorophenyS)cyc!opropane-I-carboxamsdo)-3-fiuoro-2-methvlben ¾amsde

Isolated as a white (0.062 g, 89%).

trans~N~(4~ Am no~2-me enyS)~2~chSoro-5~(2 _f 2~dichSoro-3~(3 _f 5~ dichiorophenyS)cyci

Isolated as a white solid (0,053 g, 83%),

f-(3-Amino-2 _? 4-d!fluoropheny -2-chloro-S-((i _{1 f} 3^)-2 _? 2-dich!iro-3- (3,4- dichforopheny!)cycfopropane~l~carboxamido)benzamide (DPI}

Isolated as a white solid (0,115 g, 89%),

f-(5-Amino-2 _? 4-difluoropheny -2-chloro-S-((i _{1 f} 3^)-2 _? 2-dich!iro-3- (3,4- dichforopheny!)cycfopropane~l~carboxamido)benzamide (DPS)

Isolated as a white solid (0, 107 g, 96%).

E ample 14; Preparation of fraiis~ ¥~(2~amino~4-fluorophenyf )~2~chloro~5~(2 _f 2~ dich!oro-3-C3,4-dichSorophenv!)c¥clopropane-l-carboxamido}b enzar!i!de (DP6)

To a slurry of irans-2-chloro-5-(2,2-dichloro-3-(3,4-dichlorophenyl)cyclopr opane- l-carboxamido)-A/-(4~f!uoro-2-nitropbenyl)benzamide (DP13) (0.880 g, 1.49 mmol) in a 4: 1 mixture of methanol (14 mL) and water (4.7 mL) were added iron powder (0,415 g, 7,44 mmol) and ammonium chloride (0,239 g, 4,46 mmol), and the mixture was warmed to 55 °C and stirred for 21 hours. The reaction mixture was filtered through a pad of Cellte ^® , washing with ethyl acetate. The filtrate was concentrated under reduced pressure, and the residue was partitioned between ethyl acetate (100 mL) and water (60 mL). The phases were separated and the organic phase was dried over magnesium sulfate, filtered, and concentrated to give a dark residue, The residue was dissolved In minimal ethyl acetate and adsorbed to Celite ^® . Purification by automated flash chromatography using a gradient of 0-40% ethyl acetate in hexanes as eluent gave the title compound as a yellow foam (0.66 g, 75%).

The following compounds were prepared in iike manner to the procedure outlined in Example 14:

-{2~Amino~3~f!uorophen¾ff )-2-chloro~5~({ l ? _f 3 ?)-2 _i 2~dschSoro~3~i3~chforo~4~ f uorophenyS)cyclopropane-l~carbo3 amido}b8nz:am!de (F1133)

Isolated as a light brown powder (0.030 g, 80%),

-{2~Amino~4 _f 5~diffuorophenyS)~2~chforo~5~i(l ?,3l?}~2 _f 2~dich!c5ro~3-{3~ch!oro- 4~ffuoroph8nyf )cycSopropane~l-carboxamido)benz:amsd8 (F1134)

Isolated as a light brown film (0.016 g _f 34%).

M~(5-Amino-2~f!uoro~4~methyl phenyl )-2~chioro~5-({ lR _f 3^)-2,2-dichforo~3~(3- ch!oro-4-f!uorophenyS)cvciopropane- l-carboxamido)ben2:amsde (F I 135)

Isolated as a l ight blue sol id (0.050 g, 59%) ,

Example 15: Preparatso of trans- f-(4-ammo-2 _f 3-ds!T!ethv!phen¾f!)-2-ch!oro-S- (2 _f 2-d!chSoro-3-(3 _f 5-dich!orophenyS)cyc!opropane-I-carboxamsdo)ben¾am!de (F1229)

Iron powder (325 mesh; 0.065 g, 1.163 mmol) was added to a sti rred solution of ethano! ( 10 mL) and concentrated HCi (0.01 mL, 0. 116 mmol) . The suspension was heated at 65 °C for 1 hour and then cooled to 55 °C. A solution of ammonium chloride (0.045 g, 0,838 mmol) in water (3 mL) was added, followed by irans-2-chloro-5-(2,2- dichloro-3-(3,5-dichlorophenyl)cyclopropane- l-carboxamido)-/V-(2,3-di methyl -4- nitrophenyl)benzamide (F1180) (0.140 g, 0.233 mmol) . The reaction mixture was heated to 60 °C for 2 hours, cooled, and filtered through a pad of Ceilte ^® . The filtrate was extracted with ethyl acetate (3 x 20 mL) . The combined organic extracts were washed with water and brine, dried over anhydrous magnesi um sulfate, filtered, and concentrated under reduced pressure on a rotary evaporator. Purification of the crude product by silica gel flash chromatography afforded the title compound as a ta n solid (0,032 g, 23%)

The following compounds were prepared In like manner to the procedure outlined in Exampie IS: fraiis~ ¥~(4~Amsno~2 _f 5~dimethyf phenyl )~2-chloro™5~( 2 _f 2~dichSoro~3-{3 _f S~ dichforopheny!)cycfopropane~l~carboxamido)ben2amide (F1257)

Isolated as a gold foam (0.047 g, 36%).

Example 16: Preparation of frans-2-chSoro-5-(2 _f 2-dsch 3ro-3-(3,5- dich!orophenyS)c¾ ^r c!opropane-i-carboxamido)-Af-{2 _i ,4-dif!uoro-3- hydroxypheny berwamsde (F12Q3)

trans-3-(2-Chloro-5-(2,2-dichloro-3-(3,5-dichlorophenyl)cydo propane- l- carboxamido)benzamido)-2,6-difluorophenyl acetate (F1193) (0.067 g, 0, 108 mmol) was dissolved in methanol (2,2 mL) and treated with saturated sodium hydrogen carbonate solution (0.5 mL) with stirring at room temperature. Analysis of the reaction mixture after 1 hour by thin layer chromatography (2: 1 hexanes-ethy! acetate) indicated that the reaction was complete. The reaction mixture was partitioned between ethyl acetate and IN aqueous hydrochloric acid, the layers were separated, and the organic layer was dried over sodium sulfate. Purification by preparative thin layer

chromatography (20 x 20 x 0.2 cm plate, 3 : 1 hexanes-ethy! acetate) gave the title compound as a tan foam (0,06 g, 96%),

E ample 17 : Preparation of tert-butyl~i¥~ferf~butoxvcarbonvf~i¥~[3~[2-chloro~

[5-[[(lW _f 3W}-2,2-dlchloro-3-(3,5- dichlorophenyS)cyclopropanecarbonynamino]-3-fluorobenzovl]am !no]-2 _f 6- diff uorophenyl]carbamate (FI292)

( l ?,3 ¾)-2,2-Dichloro-3-(3,5-dichlorophenyl)cyclopropane- l-carboxylic acid

(C91) (0, 131 g, 0,436 mmol) as a slurry in toluene (4 mL) was treated with oxalyi chloride (0,382 mL, 4,36 mmol) and a single drop of Λ/,/V-dimethyl formamide with sti rring at room temperature. After the mixture became homogeneous and gas evol ution ceased, the solution was concentrated to a clear oil . tert-Butyl-/V-tert-butoxycarbonyl-/V- (3-(5-amino-2-chloro-3-fluorobenzamido)-2,6-difluorophenyl)c arbamate (C 108) (0.225 g, 0.436 mmol) and sodi um bicarbonate (0. 110 g, 1.31 mmol) were added to the flask as solids followed by ethyl acetate (4 mL), and the cloudy mixture was allowed to stir at room temperature for 18 hours, Analysis of an aliquot by liquid chromatography / mass spectroscopy i ndicated complete conversion to the desired compound. The reaction mixture was partitioned between ethyl acetate and an aqueous mixture of sodium hydrogen carbonate and sodi um chloride. The layers were separated and the organic layer was dried over sodi um sulfate, filtered and concentrated to an oi l. Trituration with hexanes and dryi ng yielded the title compound as an off-white solid (0,347 g, 100%) ,

The following compounds were prepared In like manner to the procedure outlined in Example 17;

ferf-Butyf~M~ferf~butoxycarbonyS~M~(3~i2~chforo~5~i( l ?,3l?}~2 _f 2~dich!oro~3- (3 _f 4 _f 5~trich!orophenyS )cvc!opr >pan8~l-carb >3 am!do)~3~f uorobenzamido)~2,6- difluoropheny!)carba ate (F1294)

Isolated as an off-white solid (0,367 g, 100%) , ferf-Butyf (3-(2~chSoro-5-{(ll?,3l?)~2 _f 2~dich!oro~3~{3,5- dichforopheny!)cycfopropane~l~carboxamido)~3-fluorobera:am!d o)~2 _f 6~ diff uoropheny!}carbamate (F1326)

Isolated as a yellow glass (0.240 g, 99%),

ferf-Buty {3-(2-chloro-5-(( l^ _i ,3^)-2 _f 2-d!chSor i-3-(3 _f 4- dichlorophenyS)cyclopropane-l~carboxarnido}~3~ffuorobenzamid o)~2,4~ difluoropheny!)carbamate (F1328)

Isolated as a yellow glass (0.245 g, 100%),

fert-Buty! (3-C 2-ch!oro-S-{(l^,3^)-2,2-dicbSoro-3-(4-f!uoro-3- (tnfluoromethyS}pheny!)cyc!opropane-I-carboxarnido)-3-f uorobenz:amido)- 2 _f 4-dif!uoropheny!)carbamate (F1329)

Dich!oromethane (2 mL) was added to a 20 mL glass via! containing 5-amino-2- chloro-W-(4-fluorophenyl)benzamide (C9B) (0, 105 g, 0.396 mmol), 4- dimetby!aminopyridine (0,053 g, 0,436 mmol), frans-3-(3-bromo-4,5-dichlorophenyl)- 2,2-dichlorocyclopropane-l-carboxylic acid (C29) (0, 150 g, 0.396 mmol) and l-ethyl-3- (3-dimethylaminopropyl)carbodiimide hydrochloride (0, 114 g, 0,594 mmol) at room temperature. The reaction mixture was stirred at room temperature for 72 hours, concentrated, and purified by silica gel flash column chromatography using 0-100% ethyl acetate/hexanes as e!uent to give the title compound as a yellow foam (0, 118 g, 45%), The following compounds were prepared in like manner to the procedure outlined in Example 18;

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{2~chSoro~5~

(tnf uoromethvOphenyi}cvcfopropane-l-carboxamido}-/y-(2,4- difluoropheny!}ben¾amide (F1004)

Isolated as a white foam (0.056 g, 61%).

frans-5-(3-(3-Bror!io-4,5-dich!orophenyt)-2,2-dich!orocvc!op ropane-l- carboxamsdo)-2-chloro-Af-{4-f uorophenyS)ben¾amsde (FiOOS)

Isolated as a yellow foam (0.0959 g, 77%),

frans-S-CS-CS- romo-^B-dichloropheny - ^-dich!orocycSopropane-I- carboxamsdo)-2~chloro~Af~{2 _f 4~difluorophenyf)beniamide (F1007)

isolated as a yellow foam (0.0878 g, 70%).

frans-l-Ch oro-B-i _f Z-d!ch!oro-S-Cperftuoropheny cyc!opropa carboxamsdj}-W- -dif!u3rophenyS)benzamsde (F1009)

Isolated as a white foam (0.068 g, 71%).

frans-5-(3-{3-Bromo-4 _i .S-dif!uoriphenyl)-2 _f 2-dschSorocyciopropane-l- carbo5amido)~2~chSoro-/¥~{2 _f 4~d!ffuorophenyf)benz:amide (F1011)

Isolated as a white foam (0.031 g, 22%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-(3 _f 4-dich oro-5-fluorophenyS}cvclopropane-I- carboxamsdc5)-i¥~(2 _f 4~d!ffuc5rophenyS}benz:amsde (F1024)

Isolated as a white solid (0.023 g, 16%).

ίτ3«5-5-(3-(3-ΒΓθΓπο-5-{ 6ηΐ3ΑυοΓθ-λ ^δ -§ϋ ί3η Ί) ΗΘηνΙ}-2,2- dich!orocvc!opropane-i-carboxamido)-2-ch!oro-W-(2 _f 4- difiuoropheny^benzamide (FI031)

Isolated as a white foam (0.066 g, 52%).

cs-5-(3-(3-Bromo-5-(pentaf!uoro- ⁶ -suSfany!)pheny!)-2,2- dich!orocvcSopropane-I-carboxam!do)-2-ch!oro- -(2 _? 4- nyS)ben¾am!de (F1032)

Isolated as a clear colorless oil (0.031 g, 24%),

c/s~2-Ch!oro~S~{2,2~dichforo~3~(3~chloro~2 _f 4~difSuorophenyl)cyclopro^ carboxamsdj}-W- -dif!u3rophenyS)benzamsde (F1033)

Isolated as a white foam (0.043 g, 29%).

f ^, ra«s-2-Ch jro-5-(2,2-d!ch!oro-3-{3-chtoro-2 _f 4-difluorophenyS}cyc carboxamsdj}-W-(2,4-dif!u3rophenyS)benzamsde (F1034)

Isolated as a white foam (0.033 g, 22%).

trans~2~Cyano~5-(2,2-dichloro~3~{3,5-dichforopheny!)cycfo propane~ carboxamsdj}-W-(2,4-dif!u3rophenyS)-N-methytbenzamide (F1039)

Isolated as a white foam (0.043 g, 38%).

trans~ ~Af !yf-2-ch!oro~ ~(2~cyano-4-flu >rophenyf )-5~(2 _f 2~dichSoro-3-{3 _f dichlorophenyS)cyclopropane-l-carbo amido}benz:amsde (F1055)

Isolated as an orange foam (0, 144 g, 47%).

frai s~2~Chforo~5-(3~(3 _f S~dichSorophenyf )~2 _f 2~diffuorocycSopropane~l~ iamsdo)~i¥~f4~f!uorophen¥l}benzar

Isolated as an off-white solid (0.128 g, 84%).

2-Ch!oro-5-(3-(3,5-dich!orophenyi)-2,2-difiuorocycfopropanc amsdo)-i¥-(2 _f 4-d!fiuorophenyS)benz:amsde (F10S8)

Isolated as a white powder (0.127 g, 80%).

frans~ferf~Butyl i3~(2~chforo~5-(3~(3 _f S~dichSorophenyf )~2 _i - difluorocydopropane-l-carboKa ido}benzamido}-2,6~

difluoropheny!)carbamate (F1070)

Isolated as a white powder (0.150 g, 83%),

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 4-dich 3rophenyS)cyc 3propane-l- carboMamsdo)-i¥-(2,4-d!fiuoro-3-(methy!amino)phenyS)- -methytbenzamide (Fi071)

Isolated as a beige foam (0.061 g, 95%).

frans-2-Ch!oro-/¥-(2-cyano-4-fluoropheny!)-5-(2 _f 2-dsch 3ro-3-(3,5- dich!orophenyS)cyc!opropane-i-carboxamido)-Af-{prop-2-yn-l-y }benz:a!T!ide (F1072)

Isolated as a yellow foam (0.066 g, 50%).

frans-(2-Chtoro-/¥-(2-cyano-4-fSuoropheny }-5-(2,2-dichSoro-3-(3 _f 5- dich!orophenyS)cyc!opropane-i-carboxamido)ben¾amsdo)methy! acetate (Fi084)

Isolated as a yellow film (0.026 g, 22%), fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{4~iodophenyl)cvclopropane~l~carbo aniido)- J¥~(2,4~diffuoroph8nyf)benzamide (F1087)

Isolated as an off-white powder (0,14 g, 72%),

frais~2~Chforo~5-(2,2~dichloro~3~(3~iodophenyf)cycSopropa ne~l~carbc5Mamido)~ i¥~(2 _f 4~difluorophenyf)benzamide (F1088)

Isolated as a brown semisolid (0,14 g, 68%),

fra«s-2-Ch 3ro-5-(2 _f 2-d!ch!oro-3-{4-(pentaffuoro-A ^s - sulfanyl)pHeny!)cycopropane-l-carboxamsdo)-i¥-(2 _f 4- difluoropheny^benzamide (FI0S9)

Isolated as a white foam (0,14 g, 72%).

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3~{pentafSuoro~A ⁶ ~

sulfanyf)pheny!)cycopropane~l~carboxamsdo)-i¥~(2 _f 4~

dif uoropheny!)benramide (F1090)

Isolated as a brown semisolid (0.15 g, 73%). fraiis~2~Chforo~M~(2~cyano~4-f!uorophenvl)-5~(2 _f 2~dichforo~3~(3,5~ dichforopheny!)cycfopropane~l~carboxamido)~/¥~ethySben¾ami de (F1091)

Isolated as a colorless film (0,083 g, 43%),

frans-/ '-Ben¾¥ 2-chi 3ro-M-(2-cyano-4-f!uorophen¥S}-5-{2,2-dsch!oro-3-(3,S- dich!orophenyS)c¥c!opropane-i-carboxamido)ben¾amsde (F1099)

Isolated as a yellow foam (0.228 g, 60%),

frans~i¥~(3~Amsno~2 _f 4~difSuorophenyl)~2~chloro-5~{2 _f 2~dich!oro~3~(4~ iodopheny!}cydapropane-l-earboxamido}benzamsde (F1140)

Isolated as an off-white powder (0,087 g, 42%).

frans-W-(3-Ammo-2 _f 4-dsfluor ipheny!)-2-ch!oro-5-(2 _f 2-dschSoro-3-(3 sodopheny!)cycfopropane~l~carboxamido)benzamide (F1141)

Isolated as a gray foam (0.081 g _f 40%). fraiis~ ¥~{3~Amsno~2 _f 4~difSuorophenyl)~2~chloro~5~(2 _f 2~dich!oro~3~{4~

(pentafiuoro- A ⁶ ~sulfanyf )phenyS}cycfopropane~l~carbo3 amido)ben¾amide (FI 142)

Isolated as a white powder (0.073 g, 36%).

frans-W-(3-Ammo-2 _f 4-dsfluor ipheny!)-2-ch!oro-5-(2 _f 2-dschSoro-3-(3- (pentafluoro- A ^e -suffanyf )phenyl)cycfopropane~l~carboxamsdo)benzamide (F1143)

Isolated as an off-white foam (0.074 g. 36%).

trans~2~chl >ro~5~{2,2~dschSor >-3~(3~!odophenyS}cycfopropan8~l-carb >3 amido)~ i¥-(3~(2,2~difluoroacetamido)~2 _f 4~dif uorophenyS)benz:amsde (F1281)

Isolated as a tan powder (0,078 g, 49%).

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-(3-{pentafSuoro-A ^s - sulfany P^sny!)cyc opropane-l-carboxamsdo)-i¥-(3-(2 _? 2-d!f!u iroaceta!T!ido)- 2 _? 4-dif!uorophenyi)benzamide (F1293)

Isolated as a pa!e yellow foam (0.046 g, 29%).

ferf-butyS ~tert~butoxycarbony!~M-[3~[[2~chSoro-5-[[{l^ _f 3 )~2 _f 2 Soro-3- (3,4~dich!orophenyS)cyc!opropan8carbonyl]amino]benzoy ]~methyS amino]~2,

Isolated as a white foam (0.149 g, 65%) : 'H NMR (500 MHz, Methanol-^) δ 7.92 (s, OH), 7,84 - 7.59 (m, 2H), 7.59 - 7.42 (m, 4H), 7.28 (ddd, J = 15.3, 8.4, 2.1 Hz, IH), 7.22 (d, J = 8.9 Hz, IH), 7.00 (t, J = 9.2 Hz, IH), 3.55 (dd, J = 16.9, 8.3 Hz, IH), 3.41 (s, 3H), 3.25 - 3.19 (m, IH), 3.13 (d, J = 8.3 Hz, IH), 1.41 (s, 8H), 1.34 - 1.22 (m, 9H); ⁱ⁹ F NMR (471 MHz, Methanol-^) δ -119.20, -120.57, -121.26 (dt, J = 9.4, 4.8 Hz), -124.91, -125,98; ESIMS m/z 792 ([M-H] ).

trans-tert-Butyl (3-(2-ch oro-5-(2 _f 2-d!chSoro-3-C3,4- dich!oropheny cyciopropane-l-carboxamido)-W-methySben2:amsd i)-2 _i ,6- dif!uorophenyl)(methyS)carbamate (CF2)

Isolated as a white foam (0.081 g, 40.6%) : *H NMR (500 MHz, Methanol-^) δ 7.90 (d, J - 24.5 Hz, IH), 7.71 (d, J - 13.8 Hz, IH), 7.56 - 7.44 (m, 3H), 7.38 (s, IH), 7.31 - 7.25 (m, IH), 7.22 (dd, J - 8.9, 1.8 Hz, IH), 6.93 (t, J - 9.1 Hz, IH), 3.55 (dd, J = 22.7, 8.3 Hz, IH), 3.42 (d, J = 1.7 Hz, 3H), 3.22 (q, J = 3.3 Hz, IH), 3.18 (s, OH), 3.14 (d, J = 8.1 Hz, IH), 3.09 (s, IH), 2.93 (s, 2H), 1.53 - 1.45 (m, 2H), 1,39 - 1.27 (m, 6H), 1.26 - 1.15 (m, 3H); ¹⁹ F NMR (471 MHz, Methanol -(¾) δ -118.58 (d, J = 165,0 Hz), -119.80, -120.43, -124.14 (d, J = 231,2 Hz), -126.04 (d, J = 428.3 Hz); ESIMS m/z 730 ([M + Na] ⁺ ).

ferf-Buty-M-({fert-butoxy}carbonyt)-/¥-{3-(2-chSoro-5-(( l ?,3?}-2 _i .2-dsch 3ro-3- (3,4-dichtorophenyS}cvcfopropane-l-carboxamido}benzamido)-2 _f 6- dif uorophenyS)carbamate (DP?)

Isolated as a white so!id (0.174 g, 67%),

trans~tert~&ut≠ {4-{2~chSoro-5~(2 _f 2~dichSoro-3-(3 _f 4~ dichiorophenyS)cyciopropane-l-carboxamido}ben2:amsd3}-3- methylphenyS)carbamate (DP14)

Isolated as a white solid (2,75 g, 78%),

(li? _? 3i?)~2 _f 2~DichSoro-W~{4-chloro~3~(l _i 2~dsmethyf~2~phenylhydrazine~l~ carbonyf)phenyS ~3~(3,4-dichforopheny!)cycfopropane~l~carboxamid8 (F2544)

Isolated as a pale orange foam (0.266 g, 66%).

Example 19: Preparation of tra«s~ ~(3~amsno~2 _f 4~difSuorophenyl)~2~chS (2 _f 2~dichSoro-3~(4~fluoro~3-{tnfSuoromethyf)phenyS)cyclop ropane-l~

carboxamsd j}- -methyiben¾amide (Fill 2}

Step 1 : ferf-Butyl v-terf-butoxycarbonyl-/V-[3-[(2-chloro-5-nitro-benzoyl)- methyl-amino]-2,6-difluoro-phenyl ]carbamate (C144) (0.138 g, 0.225 mmoi), ammonium chloride (0.0409 g, 0.764 mmoi), and Iron powder (0.0711 g, 1.273 mmoi) were taken up i n methanol (2,4 mL) and water (0,8 mL) to give a black suspension. The reaction mixture was heated to 60 °C for 5 hours. The reaction mixture was filtered and the fi ltrate was washed with ethyl acetate. The combined organic layers were washed with water, dried over magnesium sulfate, and evaporated to give the crude material as an orange oil, which was used without purification,

Step 2: The crude aniline was dissolved in dichloromethane (2422 uL) to give an orange solution. 4,0 M Hydrogen chloride i n 1,4-dloxane (606 μ!_, 2,422 mmoi) was added and the reaction mixture was stirred at room temperature overnight. The volatiles were removed. To the residue was added trans-2, 2-dich!oro-3-(4-fiuoro-3- (trifluoromethyl)phenyl)cyclopropane- l-carboxylic acid (€76) (0.077 g, 0.242 mmoi) and /V,/V-dimethylpyndin-4-amine (0,0592 g, 0.484 mmoi) in dichloromethane (2422 μ!_) to give a yel low suspension. /V-(3-Dimethylaminopropyl)-/V'-ethylcarbodiimide hydrochloride (69.6 mg, 0.363 mmoi) was added and everything went Into solution, and the reaction mixture darkened to a deep blue color. The reaction mixture was sti rred at room temperature for 3 hours. The volatiles were removed . Purification by flash col umn chromatography using 0- 100% ethyl acetate/hexanes as eluent provided the title compound as a pale yellow foam (0, 061 g, 39%) .

The following compounds were prepared in like manner to the procedure outlined in Exampie Ϊ 9 :

trans~ ~Af !yf~ ~(3~amsno~2 _f 4~difSuorophenyS}~2~chSoro~5-{2 _f 2~dichforo~3~(4~ f uoro~3~(trif!uoromethyS}phenyl )cvclopropane~l~carboxamido)benzamide

CF1113)

Isolated as a yellow foam (0, 042 g, 49%),

f ^, ra«s-M-(3-Amsno-2,4-dsf!uoropheny!)-2-ch!oro-S-(2,2-d schSoro-3-(4-ftuoro-3- (trifluoromethyl )phenyl)cyclopropane-l-carboxamido)- V-(prop-2-yn-l- y benzamsde (F 1114)

Isolated as a yellow foam (0.054 g, 35%).

Example 20; Preparation of trans- 2 _f 6~dich!oro~3~(2,2~dichforo~3~(3-chloro~4~ ffuoropheny!)cycfopropane~l~carboxamsdo)-i¥~{2 _f 4~diffuorophenyf }benz:amide (F1105):

To a solution of trans-2, 2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-l- carboxyilc acid (C40) (0.040 g, 0, 14 mmol), 3~amlno~2,6-dlchlorG~A/~(2,4- difluorophenyl)benzamide (CI29), (0.045 g, 0, 14 mmol), and pyridine (0,034 g, 0.43 mmol) in ethyl acetate (4 mL) was added a 50% solution of 2,4,6-tripropy!-l,3,5,2,4,6- trioxatriphosphinane 2,4,6-trioxide (0.17 mL, 0.28 mmol) in ethyl acetate. The resulting colorless solution was stirred at 50 °C for 16 hours and cooled to room temperature. The reaction mixture was adsorbed to Celite ^® (~1.5 g) and purified by automated flash chromatog aphy using a gradient of 0-55% ethyl acetate in hexanes as eluent to give the title compound as a white solid (0.083 g, 100%),

The following compounds were prepared in like manner to the procedure outlined in Example 20:

fert-Buty (3-(2-ch oro-5-((I^ _? 3 ?)-2 _f 2-d!ch!oro-3-{4-f!uoro-3- (tnfluoromethyS}phenv!)cvc!opropane-I-carboxamido)benzarn!do )-2 _f 6- diff uorophenyl)carbamate (F10S3)

Isolated as a white foam (2.43 g, 89%).

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-(4-f!uoro-3-methy S- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(2, 4~

diff uorophenyl)benzamide (F1066)

Isolated as a white foam (0.059 g, 31%).

c/s~2-Ch!oro~S~{2,2~dichforo~3~(4~ffuoro~3~methyl~5- (trif!u 3romethvt}phenv!}c¥cSopropane-l-carboxamido}-i¥-(2 _f 4- dif!uorophen¥S)benzamide (FI067)

Isolated as a white foam (0.050 g, 26%).

frans~ierf~ButyS~{3~(5~{3~(3~bromo~5~(trifluoromethyf )phenyS}~2 _f 2~ dichforoc¥c!opropane~l~carboxamido)~2~chlorobenzamido)~2,6~ diff uorophenyl)carbamate (F1073)

Isolated as a white solid (0.129 g, 82%).

ferf~Butyf~(3~i2-chforo~5~((lS _f 3S)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3 amido)ben¾amido)~2 _f 6~ diff uorophenyl)carbamate (F1074)

Isolated as a white solid (0.542 g, 73%). fraiis~tert~ButyS-{3~{2~ch!oro~5~{2,2~dichforo~3~(4-chforo~3 ~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3 amido)ben¾a

dif uoropheny!}carbamate (F1077)

Isolated as a white solid (0.143 g, 85%).

fraiis~tert~ButyS-{3~{2-ch!oro~5~{2,2-dichforo~3~(4-ff uoro-3~

(tnf uorom8thvOphenyi}cvcfopropane-l-carboxamido}benzamido)- dif uoropheny!)carbamate (F1078)

Isolated as a white solid (0,047 g, 68%).

frans-ferf--ButyS-(3-{2-cbtoro-5-{2,2-dich!oro-3-C 3-f uoro-5- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)ben2:a!T!!do)-2 _? 6- dif uorophenyS)carbamate (F1Q92)

Isolated as a white solid (0.199 g, 86%).

frai s~5-{3~{3-bromo~2 _f S~diffuorophenyf )~2 _f 2~dichSorocycSopropane~l~ carboxamsdo}~2~chloro~/¥~(2 _f 4~difluorophenyf )benzamide (F1093)

Isolated as a c!ear colorless oil (0.042 g, 38%).

frans-ferf-Butvl-{3-C 5-{3-C3-bromo-2 _i 5-difSuorophenv! )-2 _i ,2- dichlorocycSopropane~l~carboxamido)~2-chforoben-iamido}~2 _f 6~

diff uorophenyS)carbamate (F109S)

Isolated as a white solid (0.058 g, 26%).

fra«s-3-(2,2-DichSoro-3-(3-chSoro-4-fSuoropheny )cyc!opropane-l- carboxamsd j}-2, -dsf!uoro-W-(4-f uoropheny!}ben¾amsde (F1 IOO)

Isolated as a white solid (0.074 g, 91%).

frans-/y-(4-Acetarii!dopheny!)-3-(2,2-d!ch!oro-3-{3-ch!or o-4- f uorophenyt)cyc!opropane-I-carboxamsd j}-2,6-dsf!uoroben¾amide (FI IO!)

Isolated as a white solid (0.030 g, 90%).

trans- M~(4~Acetamidophenyf )~2,6-dichforo~3~(2 _i 2~dschSoro~3~i3~chforo~4~ eny!}cydopropane-l-carboxamido}benzamiide (F1102)

Isolated as a white solid (0.032 g, 71%).

trans- 2 _J ,6~Dichloro~3~(2 _J ,2~dschSoro~3~(3~chforo~4~fSuorophenyS)cycfopropane- sdo)-W~(4-ff uorophenyl)benzamide (F1103)

Isolated as a white solid (0.068 g, 88%).

2,6~Dichloro~3~(2,2~dschSoro-3~(3~chforo~4~fSuorophenyS}cydo propan8- amido)-i¥~pheny!benz:a ide (F1104)

Isolated as a white solid (0.075 g, 94%).

~(4~Aminoph8nyf )~2 _f 6~dichSoro-3-{2 _f 2~dichforo~3-(3~chloro~4~ enyS)cyclopropane~l~carbo3 amido)~i¥~methvfbenz:amsde (F110

Isolated as a tan solid (0.038 g, 53%). fra«s~tert~ButyS-M~tert~buto¾ycarbonyh ~[3~[[2 _f 6~dichSoro~3-[[2 _f 2~dichSoro- (3~chSoro-4~fluorophenyf )cycfopropanecarb >nyf ]amin >]b8nz:oyS]amsno]~2 _f 6~

Isolated as a white so!id (0.086 g, 80%).

trans~3~(2,2~DichSoro-3~(3~chSoro~4-fSuorophenyf )cvclopropane~l- carboxamsdo)~2,6~dsfluoro~i¥~phenylbenz:amsde (FllOB)

Isolated as a tan solid (0.082 g, 96%).

trans~terf~ButyhM-fert~butoxycarbonyf~/¥~[3~[[3~[[2,2~di chforo~3~

ienyS)cyclopropanecarbonyS]amsno]~2,6~diffuorobenzoyf ]a

ienySjcarbamate (F1109)

Isolated as a tan solid (0.101 g, 73%).

fraiis~tert~ButyS-{3~{5~{3~{4-bronio~3-{trifluoromethyf )phenyS)~2 _f 2 dichforocyc!opropane~l~carbo arnido)~2~chlorobenzaniido)-2,6~

Isolated as a white foam (0.179 g, 85%). fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3~chSoro~5~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)~¥~{2 ,4~ dif uoropheny!}ben¾amide (F1I18)

Isolated as a white foam (0.078 g, 83%).

frans~ferf~But¥l~(3~{2~chSoro-5~{2 _f 2~dich!oro~3-{3~ch!oro-5- (triffuoromethy!)phen¥f)cycSopropane~l~carboxamido)benzamid o)~2,6~ difluorophenv!}carba ate (F1119)

Isolated as a white so!id (0.197 g, 88%).

fra«s-2-Ch 3ro-5-(2 _f 2-d!ch!oro-3-{3,4-dich!oro-5- (trif!ujromethyt}phenv!}c¥cSopropane-l-carboxamido}-i¥-(2 _f 4- difiuorophenv^benzarnide (FI147)

Isolated as a pa!e yellow foam (0.094 g, 52%).

c/s~2~ChSoro~5~i2 _f 2~dich!oro-3-{3 _f 4~dich!oro~S~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)~¥~{2 ,4~ diffuorophenvl)benzamide (F1148)

Isolated as a clear, colorless oil (0.028 g, 15%),

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{4~chSoro~3~fSuoro~5~

(tnfuoromethv'S}phenyi}cvcfopropane-l-carboxamido}-/y-(2, 4- difuoropheny!)benxamide (F1I63)

Isolated as a clear, colorless oil (0.115 g, 62%).

c/s~2-Ch!oro~S~(2,2-dichforo~3~(4-chloro~3~ffuoro~5- (triffuoromethy!)phenyf)cycSopropane~l~carboxamido)~M~(2 _f 4~

difluoropheny!}benza ilde (F1164)

Isolated as a white foam (0.076 g, 39%).

cis~2~ChSoro~5~i2 _f 2~dichloro-3-{3 _f 5~dich!oro~4~fluorophenyf)cycSopropane-l~ carboxamido)~i¥~(2 _f 4~difluoropheny!)benzamide (F1173)

Isolated as a white foam (0.032 g, 17%).

fraiis~2~chSoro-5~{2 _f 2~dich!oro~3~(3~chforo~5-(pentaffuoro~

sulfanyf)phenv!)cycopropane~l~carboxamsdo)-i¥~(2 _f 4~

dif uoropheny!)benxamide (F1232)

Isolated as a white foam (0.088 g, 50%).

c/s~2-Ch!oro~S~(2,2-dichforo~3~{3-chloro~5~{pentafSuoro~ ⁶ ~

suSfanyf)phenyS)cycfopropane~l~carbo5amido)~I~(2 _f 4~

difluoropheny!}benza iide (F1233)

Isolated as a clear, colorless oil (0.035 g, 20%),

ferf~Butyf~ ~tert~butoxycarbony!~ ~[3~[[2~chSoro-5-C[(l^ _f 3^)~2 _f 2~dichSoro-3- (3,4~dich!orophenyS)cyc!opropan8carbonyl]amino]~3~f!uoroben2 oy!]amino]~ 2,6-diffuoropheny!]carbamate (F1282)

Isolated as a white solid (0,284 g, 80%).

ferf-Buty -M-ferf'-butoxycarbonyhM-[3-[[2-chSoro-5-[[( I¾,3^)-2 _f 2-d!chSoro-3- [4-fluoro-3-(trifluoromethvl)phenv!]cvcSopropanecarbonv!]am! no]-3-fSuoro- benzoynamino]-2 _? 6-dsfSuorophenv!]carbamate (F1283)

Isolated as a white solid (0.298 g, 83%).

trans~2~Chforo~5-(2 _f 2-dichloro~3~{2-ch!oro~5~{trsfluoromethyl)phenyf )~ cyc!opropane-l-carboxamido)-/¥-{2,2 _f -tnfSuoroethy!}ben¾amide (F200I)

Isolated as a white solid (0,069 g, 76%).

frans-B-fS-CS-Bromo-^B-dif!uorophenvO-l^-dschSorocycfopro pane-l- carbo5 amido)~2~chSoro-/¥~{2 _f 2 _f 2~trifluoroeth¾ff )benzamide (F2003)

Isolated as a white foam (0.067 g, 51%).

c/s-5~(3~(3~Bromo-4,S~dsfluoroph8nvf)~2 _f 2~dichSorocycfopropane~l~ lifk

Isolated as a white foam (0.029 g, 22%).

frans-2 _f 6-D!chloro-3-(2 _f 2-dschSoro-3-(3-ch iro-4-fluorophenvS}cvclopro carboxamsdo)-i¥-(2 _f 2 _i 3 _? 3 _i .3-pentafSuoroprop¾fn

Isolated as a white solid (0.068 g, 93%).

frans-2-Chloro-S-(2 _? 2-d!chlo!O-3-{3 _f 4-dich iro-5-fluorophenyS}cvclopro nsdo)-W~(2 _f 2 _f 2~trifiuoroethyi)benz«

Isolated as a clear colorless oil (0.077 g, 56%).

c/s~2-Ch!oro~S~(2,2-dichforo~3~(3 _J ,4~dichSoro-5~fSuorophenyl)cyc!oprop« tarn Ίύο}-Ν~( 2,2, 2~triffuoroethyf)benz«

Isolated as a clear colorless oil (0,022 g, 16%).

frans~5~(3-{3~Bromo-5~(pentaf!uoro~ ⁶ ~suffanyl)phenyf)~2 _f 2~

dichforocvc!opropane~l~carbo arnido)~2~chloro~ ~(2 _f 2 _f 2~

tnf!uorQethy!)benzamide (F2008)

Isolated as a white foam (0.065 g, 54%).

cs-S-(3-(3-Bromo-5-(pentafSuoro-¾ ⁶ -su!fanvS)phen¾f|)-2 _? 2- dichlorocycSopropane~l~carboxamido)~2-chforo~i¥~(2,2 _J ,2~

trif!uoroeth¾fl)benzamide (F2009)

Isolated as a white foam (0.039 g, 28%).

frans~2~Chforo~5-(2,2~dichloro~3~(3~ch!oro~2 _f 4~difSuorophenyS}cycfopropane~l- carboxamsdo)-W~(2 _f 2 _f 2~triffuoroethyf)benzamide (F2011)

Isolated as a clear colorless oil (0,037 g, 26%),

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-(3-chSori-2-fSuo!

(trifluoromethy!}phenyl)cydopropane~l-carboxam

tnf!uorQethy!)benzamide (F2012)

Isolated as a clear colorless oil (0,041 g, 31%),

c/s-2~ChSoro-5~(2 _f 2~dichloro-3~(3~chSoro-2~fluoro~5~

(triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3amido)~¥~{ 2,2,2- trif!uoroethyS}b8nzamide (F20I3)

Isolated as a white foam (0.055 g, 42%),

frans~2-Chforo~5-(2,2~dichloro~3~(4~fluoro~3~methyS~5~

(triffuoromethy!)phenyf)-cycfopropane-l~carbo5amido}~i¥- (2,2,2- trifluoroethyl)benzaniide (F2014)

Isolated as a white foam (0,068 g, 38%), c/s-2~ChS _f 2~dich!oro-3-(4 fluorG~3~methy 5~{tnfluoromethyl cycloprop (2 _f 2,2~tnfluoroe S)b8nramide (F2

Isolated as a gold oil (0.045 g, 25%).

3-(2,2-D!ch!oro-3-(3-ch!oro-4-f!uo

amsdo)-i¥-ethyS-2 _? 6-d!flu irobenEa!Tiidi

Isolated as a white solid (0.068 g, 91%).

-3-(2 _f -DichSoro-3-(3-chSoro-4-fSuorophenv }cyc

carboxamsdo)-2 _i ,6-dsfSuoro-W-(2 _? 2 _i .2-trif!uoroeth¾f!)be

Isolated as a white solid (0,081 g, 96%).

3-(2 _f 2-D!chloro-3-(3-chloro-4-fluorophenv )cvcS

ca amido)~2 _f 6~difSuoro~i¥-(2,2 _? 3 _f 3 _f 3~pentaf!uoroprop¾ff)benzamide (F2018)

Isolated as a white solid (0,068 g, 94%).

2,6-D!chSoro-3-{2 _i ,2-dsch!oro-3-(3-chloro-4-fluorophenvl)cycopro ca amido)~i¥-ethylbenzamide (F2019)

Isolated as a white solid (0,077 g, 88%).

2 _f 6~DichSoro-3-{2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenyl)cycfopropane~l~ carboxarru nzarmide (F2020)

Isolated as a white solid (0.052 g, 66%).

•3~(2 _f 2~Dichloro~3~(3~chloro~4~fluoroph8nyf )cycS

carbo3 amido)~2 _f 6~difSuoro~i¥~propySben2amide (F20 1)

Isolated as a white foam (0.084 g, 91%).

-2 _f 6~DichSoro-3~(2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenvl)cyc oprop _i carbo3 amido)~i¥~propylben2amide (F2022)

Isolated as a white solid (0.077 g, 90%).

Isolated as a white solid 0.067 g, 82%), trans- 2 _f 6~DichSoro-3~(2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenvl)cycopropane~ cart 303amido)~i¥-(3 _f 3 _/ 3~triffuoropropyS)benz:amid8 (F2024)

Isolated as a white solid (0.071 g, 92%).

trails- 2 _f 6~DichSoro-3~(2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenyl)cycoprop

Isolated as a white solid (0.070 g, 84%).

■2 _f 6-DichSoro-W-(3-ch!oropropy }-3-(2,2-

Isolated as a white solid (0.070 g, 88%).

3-(2,2-D!ch!oro-3-(3-ch!oro-4-f!uoropheny!)cyck

amsdo)-2 _f 6-dsfluoro-i¥-(2-fluiroethy }benz:a!T!ide

Isolated as a white solid (0,088 g, 96%).

■/y-(3-ChSoropropy!)-3-(2 _f 2-dschtoro-3-(3-ch 3ro-4- fuorophenyS)cyc!opropane-I-carboxamsdo}-2 _i 6-dsfSuoroben¾a e fF202S]

Isolated as a white solid (0,083 g, 98%).

Example 21; Preparation of trans~i¥-(3~amino~2 _? 4-dif!uorophenvf)-2~chl (2,2~dich!oro~3~(4~fSuoro~3~(tnfluorornethyf)pheny!)cycfopro pane~l~

carbo3camidG)benzami e (DPS)

Step 1: Preparation of frans~ieri~butyf~i¥-ferf~butoxycarbonyi~i¥~[3~iS~ (3~(4~ffuoro 3~trsfluoromethyl)pheny!)-2,2-dichforocyc!opropane~l~

carbo3amido)~2~chSorobenzamido)~2 _f 6~difluorophenyf]carbamate. Anhydrous ethyl acetate (3 mL) was added to a 10 mL glass tube containing irans- ^-dichioro-S- (4-fiuoro-3-(trifiuoroiTiethyi)phenyi)cyciopropane-l-carboxy iic acid (C76) (0.05 g, 0,158 mmol), and iert-butyi-A-((ieri-butoxy)carbQnyi)-A-(3-{5-arn!no-2-chioro benzamido)- 2,6-dlfluorophenyl)carbamate (CI35) (0.079 g, 0.158 mmol) at room temperature. To the resulting solution were then added pyridine (0.0374 g, 0,473 mmol) and 2,4,6- tripropyl-l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P®, 50% solution in ethyl acetate; 0.201 g, 0.315 mmol). The solution was stirred at 24 °C for 12 hours, concentrated to dryness, and purified by silica gel flash column chromatography using 0- 50% ethyl acetate/ hexanes as eiuent to give frans-te/t-butyi-W-teri-butoxycarbonyi-W- [3-(5-(4-fluoro-3-(trif I uoromethyl) phenyl) -2,2-dichlorocyclopropane-l-carboxamido)-2- chlorobenzamido)-2,6-difluorophenyl]carbamate as a white solid. (0.114 g, 86%).

Step 2 Preparation of frans~i¥~(3~amino-2 _i 4~dif!uorophenyi)~2-chforo~5~ (2,2~dich!oro~3~(4~fiuoro~3~(trifluorornethyf)pheny!)cycfopr opane~l~

carbo5amido)ben_iamide. Anhydrous hydrogen chloride solution (4,0 M in dioxane; 0,326 mL, 1,305 mmo!) was added to a suspension of trans-tert-butyl-N-tert- butoxycarbony!-A/-[3~(5-(3-(4~f!uoro 3-trif I uoromethyl) phenyl)-2, 2- dichlorocyciopropane-l-carboxamido)-2-chiorobenzamido)-2,6-d ifiuorophenyi]carbamate (0,104 g, 0.130 mmol). The suspension was stirred at 24 °C for 12 hours. The dichloromethane was then removed under a stream of nitrogen and the sample was dissolved in ethyl acetate (20 mL) and washed with saturated aqueous sodium bicarbonate (5 mL) and saturated aqueous sodium chloride solution (5 mL). The ethyl acetate solution was dried over anhydrous magnesium sulfate, filtered and concentrated under vacuum on a rotary evaporator. Purification of the residue with silica gei f!ash chromatography using 0-50% ethyl acetate/hexanes as eiuent provided the title compound as a white foam (0.043 g, 53%).

The following compounds were prepared in like manner to the procedure outlined in Example 21 :

frans-W-(3-Ammo-2 _f 4-dsfluorophenv!)-S-{3-(3-bro!T!o-5-{pentafiuoro- ⁶ - suSfanv }phenyS}-2 _? 2-dichlorocvcSopropane-i-carboxam!do)-2-ch iTObenEa!Tiide

(F1042)

Isolated as a white foam (0.079 g, 74%).

c s-M-{3-Amino-2 _f 4-d!fiuoropheny }-S-(3-(3-bromo-S-(pentafiuoro- ⁶ - suSfanv }phenyS}-2 _? 2-dichlorocvcSopropane-i-carboxam!do)-2-ch iTObenEa!Tiide

(F1043)

Isolated as a clear, colorless oil (0.028 g, 56%).

f ^, ra«s-M-(3-Amsno-2,4-dsf!uoropheny!)-5-(3-(3-bromo-4,5 -dsf!uoropheny!)-2,2- dich!orocv ^, c!opropane-i-carboxamido)-2-ch!oroben2:am!de (FI044)

Isolated as a clear, colorless oil (0.062 g, 56%),

cis~/^~(3~Amino~2 _f 4~difluorophen¥ )~5~(3~(3~bromo~4,5~diffuoropheny!)-2 _? 2- dichforoc¥c!opropane~l~carboxamido)~2~chlorobenzamide (F1045)

Isolated as a clear, colorless oil (0.032 g, 53%),

¥~{3~Amsno~2 _f 4~difSuorophenyl)~2~chloro~5~(2 _f 2~dich

!oro-5-f!u jrophenyS)cyci 3propane-l-carboMamsdo}be

Isolated as a white foam (0.085 g, 65%).

c/s-W-C3-Am!nQ-2 _f 4-d!fiuoropheny§)-2-c^^

fluorophenyl }cyc!opropane-l-carboxamido}ben-?

Isolated as a clear colorless oil (0.026 g, 82%),

amino-2,4~diffuoropheny!)~2~chforo~S~{{cis)~2,2-dichforo~3~( 3-chforo~2 _f 4~ enyS}cyc 3propane-l-carboMamsdo}benzamide (F1048)

Isolated as a white foam (0.053 g, 60%),

M-(3-Ammo-2 _? 4-dsfSuoropheny!)-2-ch!oro-5-{2 _i ,2-dsch!oro-3-(3-chloro- dif!uoropheny!)cycSopropane-I-carboxam!do)ben2:a!T!ide (Fi049)

Isolated as a white solid (0,041 g, 63%).

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-(3-chSoro-2-fSuoro-S- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(2, 4~

diff uorophenyl)benzamide (F1050)

Isolated as a white foam (0.042 g, 30%).

c/s~2~ChSoro~5~i2 _f 2~dich!oro-3-{3~chSoro-2-f!uoro~5~

(triffuorom8thyS}phenyl)cyc!opropane~l~carbo3 amid

diff uorophenyl)benzamide (F1051)

Isolated as a white foam (0.063 g, 46%).

W~{3-Amino~2,4-difluoropheny!)-2~chforo~S~({l^ _f 3^)-2,2-dichforo~3~(4-ff uoro~ 3-{trifluoromethyf )phenyS}cycfopropane~l~carbo3 amido)ben :amide (DP9)

Isolated as a white solid (1.5 g, 69%).

frans~M~(3~Amsno~2 _f 4~difSuorophenyl)~2~chloro-5~{2 _f 2~dich!oro~3~(4~fSuoro~3~ methyl~S~{trsfluoromethyl)phenyf )cyclopropane~l~carboxamido)ben2amide (F1068)

Isolated as a white foam (0.032 g, 51%).

frai s~M~(3~Amino-2 _? 4~dsf!uorophenyf )-5-{3~(3~bromo-5~

(triffuoromethv!)phenvf }-2,2~dichSorocvcfopropane~l~carboxamido)~2- chSorobenzamide (F1075)

Isolated as a white foam (0.068 g, 68%).

c/s~(3~Amino~2,4~difluorophenyf )~5~(3-(3~bromo~2,5~diffuoropheny!)~2 _? 2~ dichlorocycSopropane~l~carboxamido)~2-chforoben-iamide (F1097)

Isolated as a clear, colorless oil (0.019 g, 58%) ,

fra«s~ ¥~(3~Amsno~2 _f 4~difSuorophenyl)~S~(3-(3~bromo~2 _f 5~diflu >rophenyf )-2,2~ dich!orocycfopropane-l-carboxariiido)-2-chiorobenzar!i!de ( F1098)

Isolated as a clear, colorless oil (0.014 g, 32%) .

frans-W-(3-Ammo-2 _f 4-dsfluoropheny!)-S-{3-(4-bro!T!o-3- (triffuoromethy! )phenyf )-2 _J ,2~dichSorocycfopropane~l~carboxamido)-2~ chSorobenzami

Isolated as a white foam (0.140 g, 86%) .

frans~M~(3~Amino-2 _? 4~dsf!uorophenyf )-2-chforo~5~(2 _J ,2~dschSoro~3~(3~chforo~5~ (triffuoromethy! )phenyf }cycSopropane-l~carboxamido}benzamide (F1127)

Isolated as a clear, colorless oil (0.085 g _f 61%) .

f-ra«s-M-(3-Amsno-2,4-dsf!uoropheny!}-2-ch!oro-S-(2,2-ds chSoro-3-(3 _f 4- dichioro-5-(tr!f uoromethyS }phenyi}cycfopropane-l-carboxar!i!do}benzamide

(FI 149)

Isolated as a white foam (0.083 g, 81%).

c/s-W~C3-Amino™2 _f 4-d!ffuorophen^

(tnf uoromethvOphenyi}cvcfopropane-l-carboxamido}benzamide (FI150)

Isolated as a clear, colorless oil (0,037 g, 70%),

£r3ns-W-(3-Ammo-2 _f 4-dsfluorophen¥i)-2-^

ffuoro~5-(trif!uoromethyS)phenyl)cyc!opropane~l~carboxami do)beniamide (F1187)

Isolated as a white foam (0.072 g _f 64%),

cis- -(3-Amino-2,4-dif!uoropheny!)-2-ch!oro-5-(2,2-dichSoro-3-(4- chSoro-3- fluoro-5-(tnfluorometh l)pheny!}cycSopropane-i-carboxam!do)benz:amide (FI 168)

Isolated as a clear, colorless oil (0.024 g, 63%).

fraiis~ ¥~(3~Amsno~2 _f 4~difSuorophenyl)~2~chloro-5~(2 _f 2~dich!oro~3~{3,5~ dichforo~4~ffuorophenyS)cyclopropane~l~carbo3 amido}b8n :am!de (F11S1)

Isolated as a white foam (0.099 g, 68%).

c/s-W~C3-Amino™2 _f 4-d!ffuorophen^

f uorophenyt)cyc!opropane-I-carboxamsd j}ben¾amide (F1 I82)

Isolated as a white foam (0.038 g, 77%).

fra«s~ ¥~(3~Amsno~2 _f 4~difSuorophenyl)~2~chloro-5~(2 _f 2~dich!oro~3~{3~chforo~5- (pentaffuoro- ⁶ ~suSfanyf )phenyf )cyclopropane~l-carbo amido}benz:amsde (FI259)

Isolated as a clear, colorless oil (0.071 g, 70%).

c/s~ ¾ ^, ~{3~Amino~2 _i 4~diffuorophenyf )~2-chforo~5~(2 _f 2~dichSoro~3~{3~chSoro~5~ (pentafluoro~ ⁶ ~su!fanyl)phenyf )cycfopropane~l~carboxamido)benzamide (F1280)

Isolated as a clear, colorless oil (0.032 g, 67%). E ample 22; Preparation of fraiis~2~chSoro~5-{2 _f 2~dichforo~

dichforopheny!)cvcfopropane~l~carboxamido)~/¥~(2,4~diffu i

methoxypheny^benzamide (F I 171)

trar?s-2-Chloro-5-{2 _f 2-dich!oro-3-(3,5-dlchiorophenyi)cyclopropane- l- carboxamido)benzoic acid (C12) (0.1 g, 0.22 mmol) as a slurry in toluene (2 mL) was treated with oxalyi chloride (0.0.097 rrsL 1. 1 mmol) and a single drop of N,N- dimethylformamide with stirring at room temperature. After the mixture became homogeneous and gas evolution ceased, the solution was concentrated to a clear oil and then cooied In an ice bath under nitrogen, 2 _f 4-Difiuoro~3-methoxyanillne (0,035 g, 0.22 mmol) was added as a sol ution in pyridine (2 mL) with stirring and the reaction mixture was allowed to warm to room temperature and stir overnight. An aliquot was removed and diluted with dimethyl sulfoxide and exami ned by l iquid chromatography / mass spectroscopy which i ndicated a mixture of the desired product and starting carboxylic acid. The reaction mixture was partitioned between ethyl acetate and aqueous hydrochloric acid ( 1 N), the layers were separated, and the organic phase was dried over sodium sulfate. Purification by flash silica gel chromatography (3 : 1 hexane-ethy! acetate) gave the title compound as a green-tinted solid (0.075 g, 57%) ,

The following compounds were prepared in like manner to the procedure outlined in Example 22 :

frans-3-(2-Chloro-S-(2 _? 2-dichloro-3-{3 _f S-dsch orophenv! )cyci ipropane-l- carbo5 amido

Isolated as a light yellow foam (0.105 g, 52%) .

trans-Methyl S-CZ-chfo o-S-CZjZ-dichlo o-S-fSjS-dschfo o heny^cycf ©propane- l~carbQxamidG)benramidG)~2 _f 6~difluoroben¾)ate (F1265)

Isolated as a white foam (0,060 g, 44%) .

Example 23: Preparation of tra«s-2~chloro~5~{2,2-dschforo-3~(3 _f 5~

dichiorophenyS)cvciopropane-l-carboKamido)-/¥-(4-hydroMV '-2- methy!pheny!)foenxamiid!e (F 1224)

irafJS-2-Chloro-5-(2,2-dichloro-3-(3,5-dichlorophenyl)cyclop ropane-l- carboxamido)benzoic acid (C12) (0.221 g, 0.487 mmoi), 4-ami no-3-methylphenol

(0.072 g, 0.59 mmoi) and 4-dimethy!ami nopyridine (0.071 g, 0.59 mmoi) were weighed into a round bottomed flask. A^/V-Di metbyiformamide (2 mL) was added via syringe and -ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.19 g, 0.97 mmoi) was added with stirri ng at room temperature. After 64 hours, an aliquot was removed, diluted with di methyl sulfoxide and analyzed by liquid chromatography / mass spectroscopy which i ndicated multiple products. After 120 hours, the reaction mixture was partitioned between ethyl acetate and brine, the layers were separated and the organic phase was dried over sodium sulfate. Purification by reverse phase

ch omatography gave, in order of eiution, irans-2-chloro~5-(2,2-dichioro-3-(3,5- dichlorophenyi)cyclopropane-l-carboxamido)-A -(4-hydroxy-2-nnethyl phenyl) benzamide, isolated as an off-white solid (0,022 g, 8%) and frans-4-amino-3-methylphenyl 2-chloro- 5-(2,2-dichloro-3-(3,5-dichlorophenyl)cyclopropane-l-carboxa mido)benzoate, isolated as an off-white solid (0.064 g, 24%) : *H NMR (400 MHz, Acetone-c/e) δ 10.25 (br s, 1H), 8.40 (d, J = 2,6 Hz, 1 H), 7,96 (dd, J = 8.8, 2,7 Hz, 1 H), 7, 57 (d, J = 8.8 Hz, 1H), 7.50 (s, 3H), 6.92 (d, J - 2.6 Hz, 1H), 6.87 (dd, 3 - 8.5, 2.7 Hz, 1H), 6.74 (d, 3 - 8.5 Hz, 1H), 4.47 (ad, J - 10.7 Hz, 2H), 3.67 (ci, 3 - 8.3 Hz, 1H), 3.46 (d, 3 = 8.4 Hz, 1H), 2.17 (s, 3H); ¹³ C NMR ( 101 MHz, Acetone-ds) δ 163.94, 162.59, 144,40, 141 , 76, 137.93, 137,41, 134,71, 131 ,46, 130.64, 127.85, 127.38, 123.60, 122,74, 122,46, 121 ,84, 119,33, 114,40, 61.91, 39.23, 37, 55, 16,70; ESIMS m/z 559 ([M + H] ⁺ ) . s m le ation of fraiis~rert-butyf~(4~(2~chSoro-5~(2 _f 2~dk

)cvc!opropane~l~carbo3 amido)ben¾amido)~3~

To a solution of ieri-buty! (4-ammG-3-metby!pheny!)carbamate (CIS4) (0,052 g, 0.233 mmol) in dich!oromethane (2 mL) was added 3-(((ethylimino)methylene)amino)- /V,/V-di methylpropan- l-amine hydrochloride (0.045 g, 0.233 mmol), N,N- dimethyl pyridin-4-amine (0.021 g, 0, 171 mmol), and trans-2-chloro-5-(2,2-dichloro-3- (3,5-dichlorophenyl)cyclopropane- l-carboxamido)benzoic acid (C12) (0.075 g, 0.155 mmol). The reaction was stirred at room temperature for 14 hours. The reaction was directly loaded onto a Celite loading column and purified by flash column

chromatography using a gradient of 0 - 30% ethyl acetate/hexanes as eluent to afford the title compound as a white solid (0, 056 g, 55%) : H N R (300 MHz, DMSO-ds) δ 10,91 (s, IN), 9.90 (s, 1H), 9.32 (s, 1H), 7.90 (d, J - 2.6 Hz, 1H), 7.74 (dd, J - 8.8, 2, 6 Hz, 1H), 7,63 (t, J - 1 ,8 Hz, 1H), 7,60 - 7, 51 (m, 3H), 7.38 (s, 1H), 7.25 (q, J - 8.9 Hz, 2H), 3,64 (d, J = 8.5 Hz, 1H), 3.52 (d, J = 8, 5 Hz, 1H), 2,23 (s, 3H), 1.48 (s, 9H) ; (thi n film) 3277, 2980, 1684, 1655, 1539 cm ¹ ; ESIMS 656 ([M-H] ^" ) .

Example 25°. Preparation of fert-butv ^, S-/¥-fert-butoxv'carbonv'S-/¥-[3-[[2-ch!oro- 5-[[( ll?,3l?)-2,2-dichloro-3-(3-chloro-4-fluorophenYl)cyclopropan e- carbonv ]am!no]-3-fSuoroben¾oynafTssno]-2 _f 6-dsfluoropheny! ]carbamate

To a solution of 2~chioro-5-(( l 3,3R)-2,2-dichioro-3-(3~ch!oro-4- fl uorophenyi)cyclopropane- l-carboxamido)-3-fiuorobenzoic acid (CI) (0,360 g, 0.79 mmol) In ethyl acetate (2.5 mL) were added ferf-butyl /V-(3-amino-2,6-dlfiuoro-phenyi)- /V-tert-butoxycarbonylcarbamate (CIS2) (0.327 g, 0.95 mmol), and pyridine (0.188 g, 0. 191 mL, 2.37 mmol) followed by a 50% solution of 2,4,6-tripropyl- l,3,5,2,4,6- trioxatriphosphinane 2,4,6-trioxlde (0,94 mL, 1 , 58 mmoi) in ethyi acetate, and the resulting gold solution was warmed to 45 °C and stirred for 68 hours. The reaction mixture was concentrated and the viscous, amber residue was dissolve in minimal methylene chloride (~3 mL) and adsorbed to Celite ^® . The adsorbed material was purified by automated flash chromatography using a gradient of 0-25% ethyl acetate in hexanes as eluent to give the title compound (0, 166 g, 87%) as a white solid .

The following compounds were prepared in like manner to the procedure outlined in Example 25:

2~Chloro~5~(( l^ _f 3^}-2,2~dschSoro-3~(3~chforo-4~fSuorophenyS}cvcfopropa n8~l- carboxamsd j}-W- -fluoro-2-nitrophenv'S)ben2:amsde (F!OS!)

Isolated as a yellow solid (0,056 g, 43%) ,

2~Chloro~5~(( l^ _f 3^}-2,2~dschSoro-3~(3~chforo-4~fSuorophenyS}cvcfoprop carboxamsdo)~i ~(2~f!uoro-4~methyf~5-nitrophenyl)ben¾amide (F1082)

Isolated as an off-white foam (0.109 g, 81%) .

2-ChSoro-5-{( Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3-chloro-4-fluorophenvl)cyc opro carboxamsdo)-W- -d!f!uoro-2-nstropheny }benz:amide (Fi085)

Isolated as a yellow film (0.039 g, 28%).

2~£Η1θΓθ-5~{(Ιί?,,3ί?)~2,2~€ϊεΗ!θΓθ~3~(3, 5~€ϋεΗ1θΓο Η6πν! )ενε!ο Γο 3Π6~1~ carbo amido)~i¥~(3~(2 _f 2~d!f uoroacetamid >}~2 _f 4~difSuorophenyS )b8n :am!de (F1268)

Isolated as a white soiid (0.078 g, 55%).

2~€ΗΙθΓθ~5~((1 ?,3Ι?)-2,,2~€ΐί€Η!θΓθ~3~(3~€ΗΙθΓθ~4~Ώυο Γο Ηβπν1}εν€!ο Γο 3Π ~1- carboxamsdo)-W~(3-(2,2~diffuoroacetamido)~2 _? 4-dif!uorophen¾fl)benzamide (F1270)

Isoiated as a white foam (0.084 g, 58%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 4~dichlorophenyf )cycSopropane~l- carboxamsdo)-i¥~(3-(2 _f 2-diffuoro~ ¥~methvfacetaniido)-2,4~

dif!uorophe ^, S)benzamide (FI271)

Isoiated as a white foam (0.090 g, 61%).

trans~ ~(3~Bromo~4~ffuorophenyS)~2~chforo-5~(2 _f 2~dichSoro~3~{3 _f 5~ dichlorophenyS)cyclopropane-l-carbo amido}benz:amsde (F1304)

Isolated as an off-white solid (0.18 g, 33%).

fraiis~ ¥~{2~Bromo~4~ffuoropheny!)-2~chforo~S~(2,2-dichloro~3~{3,S~ dich!oropheny!i)cydopropane-l-carboxamid©}benxamsde (F1305)

Isolated as an off-white solid (0, 18 g, 37%),

frans-W-(4-Bromo-2-f uorophenyS)-2-ch oTO-5-(2 _f 2-d!chSoro-3-C3 _i ,5- dichlorophenyf }cyclopropane-l~carboxarnido}ben.5:amsde (F1306)

Isolated as an off-white solid (0.33 g, 39%).

frans-M-(5-Bromo-2 _J .4-d!fiuoropheny }-2-ch!oro-5-(2 _f 2-d!chSoro-3-C3 _i 5- dich!oropheny cyciopropane-i-carboxamido)ben2:am!de (FI30S)

Isolated as an off-white solid (0.48 g, 34%),

fra«s~ ¥~{2~Bromo~4,6~diffuoroph8nyf )~2-chf >ro~S~(2 _f 2~dichSoro~3-{3 _f S~ i ^, f )cyc!opropane-l-carboxamido)be

Isolated as an off-white solid (0,24 g, 28%),

frans-W-(3-Bromo-4,,S-dif!uoropheny -2-ch!oro-S-{2 _? 2- dichlorophenyS}cyclopropane-l~carboxarnido}ben.5:amsd

Isolated as an off-white solid (0.62 g, 44%).

5~{2,2-dichl dichiorophenyS)cyciopropane-l-carboxamido}ben2:amsd e (FI022)

Isolated as a white foam (0,012 g, 8%),

frans-i"erf-ButyS-C3-{2-ch!oro-S-{2 _i .2-dich! iro-3-(3 _f S- dich!oropheny cyciopropane-i-carboxa!T!ido)ben2:amsd i)-2 _? 4- diff uorophenyl)carbamate (F1023)

Isolated as a white foam (0.088 g, 56%) .

£r3ns-W-(3-Acetam!dG-2 _? 4-dimethy^^

dichlorophenyS}cyclopropane-l~carboxarnido}ben.5:amsde (F 1128)

Isolated as a white so! id (0.094 g, 66%) .

trans~2~Chforo~5-(2,2-dichloro~3~{3,5-dichforopheny!)cycf opropane~l~ carboxamsdo)- ~(2 _f 3~dim8thyS-4~nitrophenyS)benz:amsde (F1180)

Isolated as a yellow solid (0.246 g, 70%) ,

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-C3 _? 5-dichlorophenyS)cyc!opropane-I- carboxamsdo)- -(2,S-d!methyl-4-nstropheny ben2:amsde ( F1230)

Isolated as a white sol id (0.041 g, 12%) .

fraiis~ ¥~(4~Bromo~2~methylphenyS}~2~chSoro~5~(2 _f 2~dichloro~3~(3 _f 5- dichforopheny!)cycfopropane~l~carboxamido)ben2amide (F 1054)

Isolated as a white powder (0.46 g, 84%),

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3-chSoro-4-fSuorophenvi }cycfopropane-l- carboxamsdo)-3-f!uoro- f-(4-fSuorophenvS)benzamide (F1 I52)

Isolated as a pale-yellow solid (0.065 g, 88%).

frans~2~Chforo~5-(2,2~dichloro~3~(3~ch!oro~4~fluorophenyf )c¥cSopropane~l~ carboxamsdo)-i¥~(2 _f 4~diff uc5rophenyf }~3~f!uorobenzamide (F1153)

Isolated as a white solid (0,077 g, 97%).

frans~£er£~But¥l-J¥~terrt

chloro~4~ffuorophenyS)cyclopropanecarbonyS]amino]-3~fluor oben-iO¥l]amino]~ 2,6-dif!uorophenyf ]carbamate (F1155)

Isolated as a light-yellow-solid (0.0185 g, 85%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3-ch!oro-4-fluoropheny!}cycSopropane-I- carboxamsdo)-3~methy!~ ¥~phenySben-iamide (F1183)

Isolated as a white solid (0.072 g, 89%).

trans~2~Chforo~5-(2 _f 2-dichloro~3~{3-ch!oro~4~fluorophenyf )cycSopropane~l carboxamsdo)-i¥~(4-ff uorophenyl)-3-methy!benzamide (F1184)

Isolated as a tan solid (0.071 g, 86%).

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-C3-chSoro-4-fSuoropheny!)cyc!opropan carboxamsdo)-W-(2 _? 4-d!f!uoropheny -3-methylben2:amide (FI 185)

Isolated as a white solid (0.070 g, 84%).

frans~i¥~(4~Acetamidophenyf }~2~chforo~5~(2 _f 2~dichSoro-3~{3~chSoro-4~ ffuoropheny!)cycfopropane~l~carboxamsdo)-3-methy!benzamid8 (F1186)

Isolated as a !ight pink solid (0.067 g, 74%),

-tert~ButyS-M~tert~but03ycarbonyh/¥~[3~[[2-chforo~5~[[2,2~d ichforo ch!oro-4-f!uorophenyS)cvciopropanecarbonynamino]-3-methytben zoyn3 2,6-diffuoropheny!]carbamate (F1187)

Isolated as a light tan solid (0.109 g, 88%).

~3~Chforo~5-(2 _f 2-dichloro~3~{3-ch!oro~4~fluorophenyf)cycSopropane- carboxamsd j}-2-methy -phenySbenzamide (F118S)

Isolated as a white solid (0,073 g, 93%).

3~Chforo~5~(2 _f 2~dichSoro-3~(3~chSoro-^

ca amido)~i¥-(4~fSuorophenyS)~2~methySben-iarnide (F1189)

Isolated as a light tan solid (0.072 g _f 89%).

frans-3-Ch!oro-5-(2,2-dichSoro-3-(3-chSoro-4-fSuorophenyi )cycf

¾H2,4-d!fi

Isolated as a white solid (0.081 g, 93%).

frans-fert-Butyl-W-tert-buto

chSoro-4~fluoropheny!)cycfopropanecarbony!]a! iino]~2~methySbenioyf3arnino]~ ~dif!iuorophenyl]carbamate (F1192)

Isolated as an off-white solid (0,043 g, 44%),

frans-3-Ch!oro-5-(2,2-dichSoro-3-(3-chSoro-4-fSuorophenyi )cycfopropane-l- carboxamsdo)-2-f!uoro- f-(4-fSuorophenyS)benzamide (F1I9S)

Isolated as an off-white solid (0.072 g, 71%)

fraiis~3~Chforo~S~(2 _f 2~dichSoro-3-{3~chSoro-4~fS

carbo3 amsdo)-i¥-(2,4-d!fiuorophenyt)-2-fSuoroben2:amsde (FI196)

Isolated as an off-white solid (0.064 g, 61%).

frans-W-(4-Acetam!dophenyl)-3-chloro-S-(2 _? 2-d!chloro-3-(3-chloro-4- ffuorophenyS)cyclopropane-l~carbo5 amido}~2~ffuorobenzamide (F119

Isolated as a white solid (0.044 g, 40%).

f ^, ra«s-terf-Buty!- -ferf-butoxycarbony!-/¥-[3-[[3-chioro-5-[[2,2-dichioro-3-(3 - chSoro-4-fiuorophenyt)cyc!opropanecarbonynamino]-2-f!u jrobenzoynamino]- 2 _f 6-dif!uoropheny!]carbamate (Fi l98)

Isolated as an off-white solid (0.099 g, 65%).

fra«s-5-(2,2-DichSoro-3-(3-chSoro-4-fSuoropheny )cyc!opropane-l- carboxamsdo)-2 _i ,3-dsfSuoro-W-phenySben2:amsde (FI207)

Isolated as an off-white solid (0.066 g, 67%),

■5-(2,2-D!ch!oro-3-(3-ch!oro-4-f!uoropheny!)cyck

carboMamsdo)-2j3-dsfSuoro-i¥-(4-f!u3rophenyS}ben2:amsde (FI208)

Isolated as a white solid (0.079 g, 77%).

frais~5~{2,2~DichSoro-3~{3~chSoro~4~fSuorophenyf)cyc!

carboxamsdo)-i ~(2 _f 4~diffuc5rophenyS}~2 _f 3~difluorobenz: isde

Isolated as a white solid (0.089 g, 84%).

fra«s-i¥-(4-Acetamidopheny )-5-(2 _f 2-dichSoro-3-(3-chSoro-4-

^)cyciopropane-l-carboxamsdo)-2 _f 3-dsfluoriben2:am!de

Isolated as a white solid (0.086 g, 78%).

ferf~ButyS~^~tert-but05ycarbonyh/¥~[3-[[5-[[2 _f 2~dich!oro~3-{3~ch !)cycfopropanecarbonyl]a™5no]~2 _f 3~difluoroben¾oyl]amino] enyl]carbamate (F1211)

Isolated as a light yellow solid (0.130 g, 89%).

■2-Ch oro-5-(2,2-d!ch!oro-3-{3-chtoro-4-f!uoropheny! carboxamsdo)-W-phenv!-3-(trifSuoro!T!ethv }benz:a!T!ide (Fi

Isolated as a tan solid (0.060 g, 76%).

frais~5~{2,2~DichSoro-3~{3~chSoro~4~fSuorophenyf)c¾fc! carboxamsdo}~3~fluoro~2~methoxy-M~pheny!benzamidi

Isolated as a tan ssolid 67 g, 86%),

■2-Ch oro-5-(2,2-d!ch! ^■ 3-{3-chtoro-4-f!uoropheny!)cycS

-3-CtnfiuQromethy benza!Tiid

Isolated as a tan solid [0.066 g, 83%).

frans-2-Ch!oro-5-(2,2-dich Gro-3-(3-chHoro

Isolated as a tan solid (0.072 g, 83%).

frans-ferf'-ButyS-/¥-ferf-butOMycarbonyi-/¥-[3-[[2-ch!o ro-S-[[2,2-d!ch!oro-3 ch!oro-4-f!uoro-phenyi}cycfopropanecarbonyi]amino]-3-(trsf!u oromethyi}- enzoyna! iinol-S^-dsfSuoro henvncar amate (F1 17)

isolated as a light-yellow solid (0.098 g, 86%).

fra«s-5-(2,2-DichSoro-3-(3-chSoro-4-fSuoropheny }cyc!opropane-l- carboxamsd j}-3-fiuoro-/y-(4-fSuorophenyS}-2-methoxvbenzamide (F1 I8)

Isolated as a tan foam (0.072 g, 89%),

fraiis~S~(2 _f 2~Dichloro~3~(3~chloro~4~fluoroph8nyf )cycSopropane~l- carboMamsdo)-i¥-(2,4-d!fiuorophenyt)-3-fSuoro-2-methoxvbenz amide (F1219)

Isolated as a light-yellow solid (0.075 g, 87%).

trans- terf-ButyhM-fert-butoxvcarbonyf ~ f-[3~[[5~[ [2,2-dich! oro~

f uorophenyS)cyclopropanecarbonyS]amino]~3~ffuoro-2~

methoxybenzoy ]amino]-2 _f 6-difluorophenyi]carbamate (F12 1)

Isolated as a light-yellow solid (0.109 g _f 94%).

fraiis~tert~ButyS-M~tert~but03 ycarbonyl~/¥~[4~[[2-chf >ro~5~[[2 _f 2~dichforo~3 (3 _f 4~dich!orophenyS)cvc!opropan8carbonyl]amino]benzoy ]aniino]~2,6-dif! phenyljcarbamate (F1266)

Isolated as a light brown solid (2,06 g, 79%),

tert-Butyf~¥~{{fert-buto¾y)carbonyS)~M-(5~(2-ch!oro~5~{ (l^ _f 3^)-2,2-dschforo-3~ ~dichSorophenyl}cycSopropane-l~carboxamido)benzaniido)~2,4-

Isolated as a white solid (0,154 g, 90%),

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f 4-dich iropheny cyciipropane-l- !sdo)-W~(4-f!uoro~2~nitrophenyS}ben-5:amsdi

Isolated as a yellow solid (0.8 g, 42%),

5-(2 _f 2-D!chloro-3-(3-chloro-4-fh eny

ca amido)~3

Isolated as a !ight-tan solid (0.058 g, 85%).

rl)cycl

,4-difi

Isolated as a light-tan solid (0.059 g, 84%).

frans-ferf-Butvl-M-tert-butoxvcarbonv'!-Af-[3-[[5-[[2 _? 2-dich!oro-3-(3-chk ffuorophenyS}c¥clopropanecarbonyS]amsnol~3~ffuoro~2~meth¥l benTOyl]3! ^' 2 _f 6~difSuorophenyl]carbamate (F1280)

Isolated as a white solid (0.099 g, 100%).

frans-5-(2 _f 2-D!chloro-3-(3-chloro-4-fluoropheny )cycSopropane-i- carbo5 amido)~i¥-ethyl~2~f!uoro~3~rnethyfbenzamide (F2029)

Isolated as a white solid (0.068 g, 83%).

•S~(2 _f 2~Dichloro~3~(3~chloro~4~fluoroph8nyf )cyck

carbo3 amido)~2~ff uoro~3~methyl~/¥~{2 _f 2,2-tnfluoro8thyS}ber

Isolated as a white solid (0.077 g, 84%).

fraiis~S~(2 _f 2~Dichloro~3~(3~chloro~4~fluoroph8nyf )cycSopropane~l- carboxamsdG)-2-fiu©rG-3-methy!-Af-( 2,2,3,3, 3-pentaf uoropropy!}ben¾amide

isolated as a white solid (0.069 g, 78%).

trans~2~Chforo~5-(2,2-dichloro~3~{3-ch!oro~4~fluorophenyf }cycSopropane~l~ carbGxamsdo}-W-ethy!-3-fliuaroben;zamsd8 (F2033)

Isolated as a white solid (0,046 g, 71%).

frans~2~Chforo~5~(2 _f 2~dichSoro-3~(3~chSoro~4~fSuorophenyl)c¾fc!opropane~l ~ carbo5 amido)~3~ff uoro~M~(2 _{f f} ~triffuoroethyf )benzamide (F2034)

Isolated as a white solid (0.061 g, 85%). fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3~chSoro~4~fSuorophenyl)cvc!opropane~l~ carbo3 am ido)~3~ff uoro~ ~(2 _f 2 _f 3,3,3~p8ntafluoropropyf )benzamide (F203S)

Isolated as a white solid (0,070 g, 89%).

ίΓ3η5-2-€Η!θΓθ-/¥-(3-εΗ θΓο Γορ Ί)-5-{2,2-€ΐΐοΗ!θΓθ-3-(3-εΗΝ

f uorophenyS)cyc!opropane-I-carboxamsdo)-3-fiuoroben2:am!de (F2036)

Isolated as a white solid (0.063 g, 87%).

frans~2~Chforo~5-(2,2~dichloro~3~(3~ch!oro~4~fluorophenyf e-!~ carboxamsdo}-i¥~8thyS-3~methylbenzamide (F2037)

Isolated as a white solid (0.055 g, 77%),

■2-Ch oro-5-(2 _f 2-d!ch!oro-3-{3-chtoro-4-f! !}cyd

carboxamsdo)-3-methy /¥-{2 _f 2 _f 2-trifluoroethy be e (F203

Isolated as a tan solid (0.052 g, 66%).

2~Chforo~5~(2 _f 2~dichSoro-3~(3~chSoro-4~fSuorophe

ca amido)~3~methy J¥~(2 _? 2 _f 3 _f 3,3-pentafluorapropy!i

Isolated as a white solid (0,054 g, 69%).

frans-3-Chloro-S-(2 _? 2-d!chlo!O-3-{3-ch!oro-4-fluorophenv!)cvcSopropane-I- carboxamsdo)-W~ethyS~2~methylbenzamide (F2041)

Isolated as a white solid (0.031 g, 44%).

trans~3~Chforo~5-(2 _f 2-dichloro~3~{3-ch!oro~4~fluorophenyf}cycSopropane~l~ carboxamsd j}-2-methv -(2 _i .2,2-trifluoroethyS)ben2:amsde (F2042)

Isolated as a white solid (0,066 g, 83%).

frans-3-Ch oro-5-(2 _f 2-d!chSoro-3-(3-chSoro-4-fSuorophen¾f!)cv'c!opripane- i- carbo5 amido)~2~methyS~/^~(2 _? 2 _f 3 _f 3,3~pentaffuoropropyS}ben.5:amsde (F2043)

Isolated as a white solid (0.071 g, 82%).

ίΓ3η5-3-ϋι!θΓθ-/¥-(3-εΗ θΓο Γορ Ί)-5-{2,2-€ΐΐοΗ!θΓθ-3-(3-εΗ!θΓθ- ^)cvc!opropane-I-carboxamsd j}-2-meth¾

Isolated as a tan solid (0.050 g, 64%).

frans~3~Chforo~5-(2,2~dichloro~3~(3~ch!oro~4~fluoropheny e-i~ carboxamsdo)-2~fluoro~i¥~(2,2 _J ,2~triffuc5roethyf )ben-iarnide

Isolated as a white solid (0.047 g, 47%)

fra«s-3-Ch 3ro-5-(2 _f 2-d!ch!oro-3-{3-chtoro-4-f!

carboxamsd j}-2-fiuoro-/y-( 2,2,3, 3,3-pentaf!uoropropy!

Isolated as an off-white solid (0.074 g, 68%),

3-Ch oro-5-(2,2-d!chSoro-3-C3-chSoro-4-fSuorophen¾f!)cvc!opropan e-i- ca amido)~i¥-ethyl~2~f!uorobenzamide (F2C

Isolated as an off-white solid (0.062 g, 63%).

frans-S-{2 _? 2-D!chSoro-3-{3-chSoro-4-fSuorophen¥ cvclopripane-i- carboxamsdo)-2 _J ,3~dsf!uoro-W~(2 _f 2 _f 2~trifluoroethyf)benzamide (F2049)

Isolated as a white solid (0.079 g, 79%).

trans~5~(2,2~DichSoro-3~(3~chSoro~4-fSuorophenyf)cvclopro pane~l~

carboxamsdj}-2,3-dsf!uoro-W-(2,2 _i .3,3 _/ 3-pentafSuoropropyi}benzamide (F2050)

Isolated as a white solid (0.092 g, 84%).

frans-5-(2 _f 2-D!chloro-3-(3-chloro-4-fluorophenv)cvcSopropane-i- carbGxamsdo)-W-ethyl-2 _f 3-d!f§UGrQbenzamide (F20SI)

Isolated as a white solid (0.073 g, 82%).

■ ¥~{3~ChSoropropvf }-5-(2 _f 2~dich!oro~3-

Isolated as a white solid (0,075 g, 76%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-(3-ch!oro-4-fl e-1- nsdo)-W~ethyS~3~(trifSuorometh¾fl)benza

Isolated as a pale-yellow solid (0.045 g, 64%).

■2-Ch oro-5-(2 _f 2-d!chSoro-3-(3-chSoro-4-fSuorophen¾f!)cvc e- carboxamsdo)-W-( -t!if uoroeth¾f -3-(tnf uoromethv!)be e (F2C

Isolated as a white foam (0.062 g, 30%) .

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3-c

samsdo)-3-{trif!uoromethyS)-Af-{3 _i ,3 _? 3-tnfluoropropv! }ben2:a!T!!de (F20S5]

Isolated as a white so!id (0.063 g, 79%).

frans-2-Chloro-S-(2 _? 2-d!chlo!O-3-{3-ch!oro-4-fluorophenv!)cvcSopropane-I- carboxamsdo)-W~(2 _f 2 _f 3,3 _? 3-pentafSuoropropyf )~3~(triff uoromethyl)benzamide

Isolated as a white foam (0.053 g, 62%).

frans-5-(2 _f 2-D!chloro-3-(3-chloro-4-fluorophenv )cvcSopropane-i- carboxarru !uoro~2~rnethoxybenzamide (F2057)

Isolated as a white foam (0.054 g, 76%).

5~(2 _f 2~Dichloro~3~(3~chloro~4~fluoroph8nyf )cyck

can 03 amido)~3~ff uoro~2~metho y~M-{2 _f 2,2-tnf!uoro8thyS}benz:amk

Isolated as a white foam (0.069 g, 86%). riyf)cyck

carbo3amido)~3~ffuoro~2-metho y~M-{3 _f 3 _f 3"tnf!uoropropvf)benzaniide (F2059)

Isolated as a white foam (0.070 g, 86%).

5-(2,2-D!ch!oro-3-(3-ch!oro-4-f!uoropheny!)cycS(

amsdo)-3-f!uoro-2-methoxy-/¥-{2 _f 2 _f 3i3 _? 3-pentaf uoropropyS amsde

Isolated as a white foam (0.069 g, 81%).

3~Chforo~5-(2 _f 2-dichloro~3~{3-ch!oro~4~fluorophenyf}cycSopropane~l~ amsdo)~2~metho3y~M~(2 _f 2 _f 2~trif!uoro8thyS)benzamsde (F2061)

Isolated as a white solid (0.060 g, 77%),

-3-Ch oro-5-(2 _f 2-d!chSoro-3-C3-chSoro-4-fSuoropheny!)cyc!opropane-i- carboxamsdo)-2-methoxy-/¥-(2 _i .2 _f 3 _i 3 _? 3-pentaf uoropropyS)ben¾amsde (F2062

Isolated as a white solid (0.075 g, 88%). ri l)cyd

caroo3cam s ^■ 2~methyl~/¥~{2 _f 2,2-tnfluoro8thyS)b8nz:a

Isolated as a white solid (0,063 g, 96%).

5-(2,2-D!ch!oro-3-(3-ch!oro-4-f!uoropheny!)cyck

amsdo)-3-f!uoro-2-methyS-W-{2 _f 2 _f 3 _i 3 _? 3-pentaf uoropropyS}ben¾am!de

Isolated as a white solid (0.059 g, 81%).

trans~5~(2,2~DichSoro-3~(3~chSoro~4-fSuorophenyf )cycl

iamsdo)~2~fluoro~ ¥~{4~fSuorophenyS)~3~m8thySbenzamide (F1136)

Isolated as a tan solid (0.078 g, 81%)

-5-(2 _f 2-D!chloro-3-(3-chloro-4-fl eny

carboxamsdo)-W-(2 _? 4-d!f!uoropheny -2-fi Ό-3-ΠΊ

Isolated as a tan foam (0.082 g, 87%). -tert~ButyS-M~tert~but03ycarbonyh/¥~[3~[[5-[[2 _f 2~dichloro~3-(3~chSoro-4~ ffuorophenv!)cycfopropanecarbonvl]3mino]~2~ffuoro~3~ni ethyl benzoyl jam mo - 2,6-diffuoropheny!]carbamate (F113S)

Isolated as a white solid (0.149 g, 83%).

~(4~Acetamidophenyf)-5~(2 _f 2~dichSoro-3~{3~chSoro~4-fSuorophenyf opropane~l~carboxamido)~2~fSuoro~3~m8thySbenzamide (Fl 139)

Isolated as a white solid (0.088 g, 85%).

frans-3-Ch oro-5-(2 _f 2-d!chSoro-3-(3-chSoro-4-fSuoropheny!)cyc!

-W-(4-fluorophenyS)-2-methoxybenzam!de (FI23S

Isolated as a white solid (0.048 g, 60%).

^■ 3~Chforo~S~(2 _f 2~dichSoro-3-{3~chSoro~4~fSuorophenyl)cyc!opropar carbo3amido)~i¥~ ~difluoropheny!)-2~metho ybenzar

Isolated as a white solid (0,059 g, 72%). fraiis~tert~ButyS-M~tert~but03ycarbonyh/¥~[3~[[3-chforo~5~[ [2,2~dich

chloro~4~ffuorophenyS)cyclopropanecarbonyS]amino]-2- methoxybenzoyna™no]-2,6-difluorGpheny!]Garbamate (F1237)

Isolated as an off-white solid (0.059 g, 52%).

Example 26: Preparation of tra«s~2~((tert-but03ycarbonyS}(4~(2~chforo-S~(2 _f 2~ dichloro~3~(3 _f 5~dich!orophenyS}cv'cfopropan8~l-carb>3amido)ben¾a mido)~3~ methylpheny!)amsno}ethy! acetate (FI129)

Step 1: Preparation of 2-((terf-butoxycarb3nyi}(3-methyi-4- nitropheny )amino)ethy acetate, tert-Butyl (3-methyl-4-nitrop enyl)carbamate (C223) (1.0 g, 3.96 mmol) dissolved in anhydrous /V,/V-dimethylformamide (5 mL) was added dropwise to a stirred suspension of sodium hydride (60% oil dispersion, 0,206 g, 5.15 mmol) in anhydrous W,W-dimethylformamide (50 mL) at a rate that maintained the temperature below 30 °C. Upon completion of the addition, the resulting orange solution was stirred at room temperature for 30 minutes followed by the dropwise addition of 2- bromoethyl acetate (0.662 g, 3.96 mmoi). The resulting solution was stirred at room temperature for 12 hours, then carefully quenched with water (100 mL), and extracted with ethyl acetate (3 x 50 mL). The organic extracts were washed successively with water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under vacuum on a rotary evaporator. Purification by silica gel flash chromatography provided the title compound as a yellow oil (0658 g, 47%); ^J H NMR (400 MHz, CDC ) δ 8.04 - 7.97 (m, 1H), 7.26 (m, 2H), 4.31 - 4.23 (m, 2H), 3.93 (t, J = 5.6 Hz, 2H), 2.62 (s, 3H), 1.97 (s, 3H), 1.48 (s, 9H); ¹³ C NMR (101 MHz, CDCb) δ 170.72, 170.58, 153.57, 146.91, 145.94, 134.81, 129.85, 125.53, 124.40, 81.83, 77, 37, 77.05, 76.73, 62.16, 62.08, 48.76, 28.21, 20.86, 20.76, 20.70; ESIMS m/z 339 ([M + H] + ) .

Step 2; Preparation of 2-((4-a ino-3-methyiphenyf ){tert- butoxvcarbony }amino)ethyt acetate. Paliadium hydroxide ( 10% w/ ^' w; 0.135 g, 0.096 mmol) was added to a sti rred solution of 2-((tert-butoxycarbonyl)(3-methyl-4- nitrophenyl)amino)ethyl acetate (0.650 g, 1 ,92 mmol) dissolved in ethyl acetate (50 mL) , The flask was evacuated and filled with hydrogen via a balloon adapter, and the resulting black suspension was stirred for 13 hours at room temperature. The reaction mixture was filtered through a pad of Cei ite ^® and concentrated under vacuum on a rotary evaporator to give the title compound as a brown solid (0.527 g, 85%) : H N MR (400 MHz, CDC ) δ 6,85 (s, 2H), 6.61 (d, J = 8,2 Hz, 1H), 4, 18 (t, J = 5.8 Hz, 2H), 3.79 (t, J = 5,8 Hz, 2H), 3,60 (s, 2H), 2. 14 (s, 3H), 2,00 (s, 3H), 1,40 (s, 9H) ; ESIMS m/z 309 ([M + H] ⁺ ) .

Step 3: Preparation of frans~2~((tert~butox¾fcarbon¾ff){4~(2~ch!oro~S~ (2,2~d!ch!oro~3~(3,5~dichforopheny!)cycfopropane~l~carboxami do)benzarnido)~ 3- ethy!phenyi)amino)ethyi acetate (F1129).2,4,6-Tripropyi- l _f 3,5,2,4,6~ trioxatriphosphlnane 2,4,6-trioxlde (T3P ^® , 50% sol ution in ethyl acetate; 0,281 g, 0,441 mmol) was added dropwise to a stirred solution of frans-2-chloro-5-(2,2-dichloro-3-(3,5- dichlorophenyl)cyclopropane-l-carboxamido)benzoic acid (C12) (0.100 g, 220 mmol), 2-((4-amino-3-methylphenyl)(ferf-butoxycarbonyl)amino)ethyl acetate (0.068 g, 0.220 mmol), and pyridine (0.053 g, 0.661 mmol) in anhydrous ethyl acetate (3 mL) . The sol ution was stirred for 12 hours at 23 °C and concentrated. Purification by silica gel flash chromatography gave the title compound as a white foam (0.149 g, 86%) .

The following compounds were prepared In like manner to the procedure outlined in Example 26:

f ^, ra«s-terf-Buty!-{4-(2-chioro-5-(2 _f 2-dichi 3ro-3-(3,5- dichiorophenyi)cyciopropane-l-carboxamido}ben2:amid 3}-3-methy!phenyS}(2- cyanoethyl)carbamate (FilS7)

Isolated as a white sol id (0.134 g, 81%) . fraiis~tert~ButyS-{4~{ 2-ch!oro~5~{2,2-dichforo~3~(3 _f 5~

dichforopheny!)cycf >propane~l~carboxamido)ben2amido)~3~methySphenvl)(2~ methoxyethy )carbamate (F1159)

Isolated as a clear colorless oil (0.121 g, 73%).

Example 27; Preparation of /¥-(4-Amino-2 _f 6-dif!u jrophenv'S)-2-chSoro-5- (( ii? _f 3^)-2 _? 2-dichloro-3-{3 _i .S-dich iTOphenv c¥ci ipropane-l- carbo5 amido)ben_iamide (F1027)

To a solution of 2-chloro-5-(( l ¾,3 ?)-2,2-dichloro-3-(3,5- dichlorophenyl)cyclopropane- l-carboxamido)benzoic acid (C13) (0.100 g, 0.220 mmo!) and fert-butyl-A/-((fert-butoxy)carbonyl)-W-(4-arni no-3,5-difl uorophenyl)carbamate (C181) (0,076 g, 0.220 mmoi) in ethyl acetate (2 mL) were added pyridine (0,036 ml_, 0.441 mmoi) and 2,4,6-tnpropyl- l,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (T3P ^® ) as a 50% solution in ethyl acetate (0,210 g, 0, 331 mmoi) . The mixture was warmed to 45 °C for 48 hours. The reaction mixture was cooled to room temperature and concentrated under a stream of nitrogen. The residue was purified by flash column chromatography using 0-30% ethyl acetate/hexanes as eiuent. Product fractions were combined and concentrated under reduced pressure, The resulting residue was dissoived in dichioromethane (2 mL), and a 4 M solution of hydrogen chloride in dioxane (0.545 mL, 2.18 mmoi) was added. The reaction mixture was stirred at room temperature for 18 hours. The solvent was evaporated under a stream of nitrogen. The residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The phases were separated, the organic layer was washed with saturated aqueous sodium bicarbonate and bri ne and then passed through a phase separator to dry, and the solvent was concentrated. Purification by flash column chromatography using 0-30% ethyl acetate/hexanes as e!uent afforded the title compound as a white solid (0,025 g, 19%).

The following compounds were prepared in like manner to the procedure outlined in Example 27:

W-{4-Amino-2 _f 6-difuorophenyS)-2-ch oro-5-({i ? _? 3 ?}-2 _f 2-dich!oro-3-{3 _? 4- dich!orophenyS)cyc!opropane-i-carboxamido)ben¾am!de (F1028)

Isolated as a white solid (0,019 g, 15%).

M-(4-Amino-2 _? 6-d!fluoropheny -2-chloro-S-(Ci^ _f 3^)-2 _? 2-dich!oro-3-(3 _f 4 _f 5- tr!chSorophenyl)cycSopropane-l-carboxam!do)ben2:a!T!!de (F 1.029}

Isolated as a white solid (0.022 g, 17%).

W~{4-Amino~2,6-difluoropheny!)-2~chforo~S~((l^ _f 3^)-2,2-dichforo~3~{3-chforo~ 4-fluorophenyf)cyclopropane~l~carbo amido)ben2amide (F1030)

Isolated as a white solid (0.019 g, 14%).

frais~M~(3~Amino-2 _? 4~dsf!uorophenyf)-2-chforo~5~(2 _J ,2~dschSoro~3~(3~

(dsfluoromethyl)~4~ffuorophenyS}cycfopropane~l~carbo3amid o)ben :am!de (F1036)

Isolated as a white solid (0.080 g, 42%). £r3«s~ ¥~{3™A ino~2 _f 4™dif!uorophenyl)~2~chlo^

(difSuoromethvf )phenyS)cyclopropane-l-carbo amido}benramide (F1037)

Isolated as a white so!id (0.086 g, 46%).

trans~ ™(3~Amino-2,4~difluGropheny!}-2-cN^

(dsfluoromethyl)pheny!)cycfopropane~l~carboxamido)benzamide (F1038)

Isolated as a light yellow foam (0.079 g, 42%) ,

frans-M-(3-Ammo-2 _? 6-dsfSuoropheny!)-2-ch!oro-5-{2,2-dsch!oro-3-(3 _? 5- dich!oropheny cyciopropane-i-carboxamido)ben2:amsde (FI026)

Isolated as a white foam (0.037 g, 76%).

fra«s~ ¥~(4~Amsno~2~m8thySpheny!)~2~ch!oro~S~(2,2~dichl >ro~3~(3,4~ dichforopheny!)cycfopropane~l~carboxamido)ben2amide (DPI)

Isolated as a white foam (0.838 g, 99%).

E ample 28; Preparation of trans- 2 _f 2~dich!oro~/¥-(4~chSoro~3-{2~{pyridin~2~ yt)bydrazine-l-carbonyi)pheny }-3-(3 _f S-dicbSoropher!yl)cycSopropar!e-l- carboxamsde (F2502)

To a solution of frai7S~2-ch!oro-5~(2 _f 2-dlchioro-3-(3 _f 5~

dichlorophenyi)cyclopropane-l-carboxamido)benzoic acid (CO) (0.080 g, 0.176 mmol) and 2-(l-methylhydrazinyi)pyridine (0.033 g, 0.265 mmol) in ethyl acetate (2 mL) at room temperature were added sequentially diisopropylethylamine (0.123 mL, 0.706 mmol) and 2,4,6-tripropyi-l _f 3,5,2,4,6-tnoxatriphosphinane 2,4,6-tr!oxide (T3P ^® ; 0.225 g, 0.353 mmol) as a 50% solution in ethyl acetate. The reaction mixture was stirred for 18 hours at room temperature and then concentrated under a stream of nitrogen. Purification by column chromatography using 0-100% ethyl acetate/ hexa es as eluent afforded the title compound as a yellow solid (0,019 g, 20%).

The following compounds were prepared in like manner to the procedure outlined in Example 28 :

trans- ,2-dich!oro-Af-{4-chSoro-3-C 2-{4-ch!oro-3- (tnfluoromethyS)phenv!)hvdra2:sne-I-carbonyS)phenyS)-3-(3 _f S- dich!oropheny!)cycfopropane~l~carbGxamide (F2501)

Isolated as a light yellow foam (0,058 g, 44%) .

trans- 2 _f 2~DichSoro~ ~(4~chforo~3~(2~methyh2~{pyridin~2~yf )hydrazsne~l~ carbony )phenyt)- -(3 _f 5-dichiorophenyS)cyciopropane-l-carboMamide (F^

Isolated as a yellow solid (0.046 g, 47%).

frans~2 _J ,2~Dichloro~i¥-(4~chloro-3~{2~(5~chloropyridin~2~yS)h ydraz:ine~l~ carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l~carboxamide (F2504)

Isolated as an off-white solid (0.045 g, 44%),

frans-2j2-DichSoro-W-(4-ch!oro-3-C2-(3-chSoropvridin-2-v! }hydrazi carbonv }phenyt)-3-(3 _f 5-dichiorophenyS)cyciopropane-l

Isolated as an off-white solid (0.036 g, 35%).

frans-2 _f 2-D!chloro-W-(4-ch!oro-3-{2-(6-chloropyridaEin-3-¾ ^r l

carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l~carboxc Mae

Isolated as a light yellow solid (0.070 g _f 69%).

■2,2-θ!εΗ!θΓθ-ί¥-(4-εΗΙθΓθ-3-( -™8ΐΗ Ί- -(4-(Ιπ^ ϋθΓθΓΠ8ΐΗνΙ n-2- V'S)hydra¾ine-l-carbony!}pheny!)-3-(3,5-d!ch!oropheny }cyc!opropan carboxamsde (F2

Isolated as a white solid (0,096 g, 86%). trans- 2 _f 2~D!chSoro~i¥~(4~chforo~3~(2~(pvr!m ids n~2-y!!)hydraz! ne- 1~ carbonyf)pheny!)~3-(3 _f S~dichlorophenyS)cyclopropane-l~carbo3amide (F2SC

Isolated as a white solid (0,027 g, 28%).

frans-2 _f 2-D!chloro-W-(4-ch!oro-3-{2-(pyrimsdm 4-yf hydrazine- 1- carbony )phenyS)-3-(3 _f S-dich!oropheny cyci ane-l-carboxamide (F25C

Isolated as a white solid (0.016 g, 17%).

?3i?)~2 _f 2~DichSoro-W~{4-chloro~3~(2-methy!~2-pheny!hydra-iine~ l- carbonyf)phenyS)~3~(3,5-dichforopheny!)cycfopropane~l~carbox amid8 (F.

Isolated as a white solid (0.045 g, 37%),

?3^)-2 _f 2-Dichloro-W-{4-chSoro-3-C2-methy 2-pheny!hydra2:!ne-l- carbony P^sny -3-(3 _? 4,S-trich!oropheny cyciopropane-l-carboxamide (F2511)

Isolated as a whte solid (0,048 g, 40%), ~(4~chSoro~3~{2~m8thyS-2~phenvf hydrazine rbonyf )phenv!)~3-(3~chforo-4~fSuorophenyS)cvc!opropan8~l-ca

Isolated as a white solid (0.041 g, 33%).

(l^ _f 3^}-2,2-Dich!oro-i¥-(4-chSoro-3-(2-methy 2-pheny!hydraxine-l- carbony )phenyt)-3-(3 _f 4-dichiorophenyS)cyciopropane-l-carboMamide (F253

Isolated as a white solid (0,057 g, 46%).

trans- 2j 2-DichSoro-W-(4-ch!oro-3-( 2-(4-fi uorophenyH )hydraxine- 1- carbony )phenyS)-3-(3 _f S-dich!oropheny cyciopropane-l-carboxamide (F25!

Isolated as a yellow foam (0.036 g, 31%).

trans- 2,, ~ΟϊεΗΙθΓθ~ ί-(4~εΗΙθΓθ-3~{2~{4~εν3πο ΗβπνΙ

carbonyf )phenyS)~3~(3,5-dichforopheny!)cycfopropane carboxamis

Isolated as a light foam (0.070 g, 63%).

f ^, ra«s-2,2-Dich!oro-i¥-(4-chioro-3-(2-{4-nitrophenyi}h ydrazine

ienyS)-3-(3,5-dich!orophenyt)cyc!

Isolated as an orange solid (0, 146 g, 66%) ,

2,2-D!chSoro-i¥-(4-ch!oro-3-(2-phenySh¥dra¾!ne- Dphenyll dich!orophenyS )cyc!opropane~l-carbo3car

Isolated as an ol T-vvhite foam (0,0911 g, 82%) .

■2.2~DichSoro-i¥- -(4~chforo~3~(2~methyl~2~phenyl hydrazine- 1- 3 _f 5-dichiorophenyS)cyci jpropane-1

Isolated as an off-white foam (0,094 g, 85%) ,

frans-2 _f 2-Dichloro-W-(4-ch!oro-3-{2-(2 _f S-d!fluoropheny! }hydraES ne-I- carbony )phenyS)-3-(3 _f S-dich!oropheny cyciopropane-l-carbox arrside (F25!

Isolated as an off-white foam (0.0796 g, 72%) ,

trans- 2,2~Dichloro~i¥~(4~chloro~3~(2~(2,4~difl uorophenyf )hydrazi ne~l~

? )phenyS)~3~(3,5-dichforopheny!)cycfopropane~l~carboxamid8 (F255*

Isolated as an ff-vvhite foam (0.089 g, 80%) .

Isolated as a l ight brown foam (0.072 g, 60%) .

2 _f 2~DichSoro~i¥~(4~chforo~3~(2~(2 _f 5~dichforophenyS}hydrazine~l- }phenyt)-3-(3 _f 5-dichiorophenyS)cyciopropane-

Isolated as a I ght brown foam (0.095 g, 79%) .

trans- 2 _f 2-Dichloro- ¥-(4-ch!oro-3-{2-(4-f!uoro-2-methv!phenv!)hvdraEine-i- "(3 _f S-dich!oropheny cyciopropane-l-carboxamide (F25

Isolated as a l ight brown foam (0.080 g, 71%) .

frai s~2 _J ,2~Dichloro~i¥-(4~chloro-3~{2~(4~metho3cyphenyS}hydra zine~l~ carbonyf )phenyS)~3~(3,5-dichforopheny!)cycfopropane~l~carboxamid8 (F25I

Isolated as a l ight brown foam (0,039 g, 35%) .

,2~Dichloro~i¥~(4~chloro~3~(2~(4~(triffuorom S)hydrazine-1~ envO-3-(3,5-dich!orophenyt)cyc!

Isolated as a l ight brown foam (0,082 g, 63%) .

,2-DichSoro-i¥-(4-ch!oro-3-(2-{4-(perf!uor iethoxv'}phenv!)hvdra2:ine-I- pheny -3-(3 _? 5-dich!orophenyS)cyc!opropane-I-carboxamide (F2565;

Isolated as a l ight brown foam (0, 105 g, 79%) .

,2-Dich!oro-i¥-(4-chioro-3-(2-{4-(tr!f uoromethy ne-1- phe -3-(3 _? 5-dich!orophenyS)cyc!opropane I-Ci

Isolated as an off-white foam (0.048 g, 38%) .

, 2~DichSoro-i¥~(4-chforo~3~(2~(3~(triffuoromethy!)phenyl)hyd ra¾ine )phenyt)-3-(3 _f 5-dichiorophenyS)cyciopropane-l-carboMamide {Ψ21

Isolated as a !ight brown foam (0.107 g, 86%).

trans- 2 _f 2~DichSoro-W~(4-chforo~3~(2-methyl~2~(m~tolyS}hydrazine~l~ carbonyf )pheny!)~3~(3 _f 5~dichlorophenyS)cyclopropane-l~carbo5 amide (F2S74)

Isolated as a light brown foam (0,030 g, 26%).

trans- 2 _f 2-Dichloro-W-(4-ch!oro-3-{ 2-(2-cyanopheny! )hydrazsne- 1- carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l~carboxamide (F2576)

To a solution of irans-2,2-dichloro-/V-(4-chloro-3-(hydrazinecarbonyl)phenyl) -3- (3,5-dichlorophenyl)cyclopropane- l-carboxamide hydrochloride (F2587) (0.25 g, 0.498 mmoi) in tetrahydrofuran (5 mL) was added triethylamine (0. 15 g, 1.49 mmol) and acetic anhydride (0.061 g, 0.598 mmoi) at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (20 mL) and washed with water (2 X 10 mL) and brine (5 mL) . The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification by column chromatography eluting with 40-60% ethyl acetate/petroleum ether afforded the title compound as a white solid (0.08 g, 32%) .

The following compounds were prepared In like manner to the procedure outlined in Example 29;

trans- 2, 2-Dichloro-Af-C4-chloro-3-(2-(2,2,2-trifluoroacetyl)hydrazin e-l- carbony }phenyt)- -(3 _f 5-dichiorophenyS)cyciopropane-l-carboMamide (F25 I5)

Isolated as a white sol id (0.06 g, 21%) . trails- 2 _f 2~DichSoro-i¥~(4-chforo~3~(2~(3 _f 3,3~tnfluoropropanoyf )hydraz!ne~l~ carbonyf )phen ~3-(3 _f S~dichlorophenyS)cyclopropane-l~carbo3 amide (F2S16)

Isolated as a white solid (0,06 g, 26%),

trans- 2 _f 2-D!chloro-W-(4-ch!oro-3-{ 2-(2 _f 2-difl uorocyd opropane- 1- carbony )hydra2:me-i-carb in l)pheny!)-3-(3 _? S-dich!oropheny!)cyc!opropa carboxamsde (F

Isolated as a white solid (0.07 g. 31%).

trans- 2,2~Dichloro~i¥~(4~chloro~3~(2~(l~cyanocycf opropane- 1~

carbonyf )hydra2sne~l~carbonyl)phenyf }-3~(3,5-dich!orophenyl)cyc!opropane~l~ carboxamsde (F251S)

Isolated as a white solid (0, 15 g, 68%), £rans™¥~(3™(2~Acetyi~2~ ethy!i hydrazine- l-carbony! }~4~chSorophenyf }~2,2~ dichforo~3~(3,5~dichSorophenyl)cycopropane~l~carboxamide (F2522)

Isolated as an off-white solid (0,02 g, 10%),

trans- 2j2-DichSoro-W-(4-ch!oro-3-(2-methy!-2-(2,2,2-trif!u3roacety S)hydraxine- l-carbonyl)pheny }-3-(3 _? S-d!chloropheny!)cyclopropane-i-carboxa!T!!de

Isolated as an off-white solid (0.04 g, 18%).

trans- 2,2-D!chSoro-i¥-(4-ch!oro-3-(2-{l-cyanicyc ipropane-l-carbony }-2- methylhydrazine~l~carbonyf)phenyf)~3~(3,5~dichlorophenyf)cyc !opropane~ carboxamide (F

Isolated as an off-white solid (0.11 g, 50%).

trans- 2 _f 2~DichSoro~i¥~(4~chforo~3~(2~(dimethyfg!ycyf )-2~methyl hydrazine- 1- carbony )phenyt)-3-(3 _f 5-dichiorophenyS)cyciopropane-l-carboMamide (F25 _*

Isolated as an off-white solid (0, 11 g, 50%),

£rans-W-(3-(2-Benroyh2-methyl hydrazine- I-earbony! )-4-chlorophenyi )~2, 2- dich!oro-3-{3,S-dich!orophenyS}cyclopropane-I-carboxamide (F2527)

Isolated as an off-white solid (0.12 g, 48%).

2,2~Dichloro~i¥-(4~chloro-3~(2~(2~cyclopropySac8t rasne- )phenyS)~3~(3,5-dichforopheny!)cycfopropane~; -carboxamid

Isolated as a white solid (0.11 g, 50%).

-2 _j ,2-DichSoro-i¥-(4-ch!oro-3-(2-{2-methoxv'acety!)hydra z!ne-I- carbonyl)P^sny -3-(3 _? 5-dich!orophenyS)cyc!opropane-I-carboxamid¾

Isolated as an off-white solid (0.09 g, 42%). trans- 2 _f 2~DichSoro~i¥~(4~chf oro~3~(2-(d ethyI g!ycyl)hydrazi ne~ 1- carbonyf )phen ~3-(3 _f S~dichlorophenyS)cyclopropane-l~carbo3 amide (F2S30)

Isolated as an off-white foam (0,06 g, 25%),

trans- 2j2-DichSoro-W-(4-ch!oro-3-C 2-p!Co!inoyShydrazsne-I-carb 3n¥S}phenyi}-3- (3 _f S-d!chSorophenvl)cycSopropane-I-carboxam!de (F253I)

Isolated as an off-white solid (0.055 g, 26%).

trans- 2, ~Dichloro~i¥-(4~ch!oro-3-{2~(3 _i 3 _f 3~trlfl uoro~2~

(triffuoromethy!)propanoyf )hydrazsne~l~carbonyl)phenvf }~3~(3,5- dichlorophenyS)cyclopropane-l-carbo amide (F2S32)

Isolated as an off-white solid (0.04 g, 16%).

trans- 2,2-D!chSoro-i¥-(4-ch!oro-3-(2-methyl-2-(3 _? 3 _f 3- trif!uoropropanoyS)hydra2:!ne-l-carbony!)phenyS)-3-(3 _? 5- dichforopheny!)cycfopropane~l~carboxamide (F2533)

Isolated as an off-white solid (0.085 g, 38%). trails- 2 _f 2~DichSoro-i¥~(4-chforo~3~(2~(2 _f 2~d!fSuorocvcfopropan8~l-carbonyf )-2~ methvlhydrazine~l~carbonvf }phenyf )~3~{3,5~dichlorophenyf )cvclopropane~l~ carboxamsde (F

Isolated as an off-white solid (0,065 g, 29%),

Example 30: Preparation of iTans-2-{2-chSoro-S-(2 _? 2-dsch!oro-3-(3 _? 5- dich!orophenyS)c¾ ^r c!opropane-i-carboxamido}ben¾oyS}-Af-{2 _i ,2 _? 2- trifluoroethyl)hydra-?ine~l-carbo3camide (F2535)

To a solution of tra 7S-2 _f 2-dichloro-A -(4~chioro-3-(hydrazinecarbonyl)phenyl)~3-

(3,5-dichlorophenyl)cyclopropane-l-carboxamide hydrochloride (F2567) (0, 175 g, 0.347 mmol) in tetrahyd ofuran (4 mL) were added triethyiamine (0.105 g, 1,04 mmol) and l,l,l-tnfluoro-2-isocyanatoethane (0.052 g, 0,417 mmol) at 0 °C, The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (20 mL) and washed with water (2 x 10 mL) and brine (5 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification by column chromatography e!utlng with 40-60% ethyl acetate/petroleum ether afforded the title compound as an off-white solid (0, 10 g, 48%),

The following compounds were prepared in like manner to the procedure outlined in Example 30 :

frans-2-{2-Ch oTO-5-(2 _f 2-d!chSoro-3-C3 _i 5-dschlorophenyS}cyc!opropane-I- carboxamsdo)benzoy!)-i¥~ssopropy!hydrazine~l~carboxarT!ide (F2536)

Isolated as an off-white solid (0.13 g, 61%).

frans-2-(2-Ch jro-5-(2,2-dich!oro-3-{3,5-dsch!orophenvt}cyc!opropane-I- carboMamsdo}benzoyS}-i¥-phenyihydra2:!ne-l-carboMamsde (F2537)

Isolated as an off-white solid (0.06 g, 26%).

frans-2-{2-Ch oTO-5-(2 _f 2-d!chSoro-3-C3 _? 5-dschlorophenyS}cyc!opropane-I- carboxamsdo)benTOyl)-i¥~(cyc!opropyfrnethyf )hydra-iine~l~carboxarnide F2S3S}

Isolated as an off-white solid (0.11 g, 50%).

Example 31: Preparation of trans- 2,2-dichSoro-/¥-{4-ch!oro-3-{2-((2,2 _f 2- tr!f!uoroethyS)carbamothioy!)hydraz:sne-I-carbonyS}pheny!)-3 -(3 _f S- dich!oropheny cyciopropane-i-carboxamide (F2539)

To a solution of trans-2, 2-dichloro-/V-(4-chloro-3-(hydrazinecarbonyl)phenyl)-3 (3,5-dichlorophenyl)cyclopropane-l-carboxamide hydrochloride (F2S67) (0.190 g, 0.377 mmo!) In tetrahydrofuran (4 mL) were added triethylamine (0.114 g, 1.13 mmo and l,l,l-trifluoro-2-isothiocyanatoethane (0.064 g, 0.452 mmol) at 0 °C, The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved In ethyl acetate (20 mL) and washed with water (2 x 10 mL) and brine (5 mL), The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification by column chromatography eiuting with 40-60% ethyl acetate/petroleum ether afforded the title compound as an off-white solid (0.08 g, 35%).

The following compounds were prepared In like manner to the procedure outlined in Example 31 :

trans- 2,2-Dich!oro-i¥-(4-chioro-3-(2-{ss 3propyScarbamoths 3v!}hvdraz!ne-l- carbony^phe -S-CS^B-dich!oropheny cyc!opropane-I-carboxamide (F2540)

Isolated as an off-white solid (0.06 g, 27%).

trans- 2,2-D!chSoro-i¥-(4-ch!oro-3-(2-{pheny!ca rbamothioy! hydrazine- 1- carbonyf )phe ~3~(3 _f 5~dichlorophenyS)cyclopropane-l~carbo5 amide (F2S41)

Isolated as an off-white solid (0.07 g, 26%).

E ample 32; Preparation of frans-ethy! 2~(2~chSoro-5-(2 _f 2~dichforo~3~(3,5~ dich!orophenyt)cyc!opropane-l-carboxamido)benx 3yf }hydra2:!ne-l-carboMySate (F2542)

To a solution of trans-2,2-dichloro-/V-(4-chloro-3-(hydrazinecarbonyl)phenyl) -3- (3,5-dichlorophenyl)cyclopropane-l-carboxamide hydrochloride (F2587) (0.175 g, 0.347 mmol) In tetrahydrofuran (4 mL) were added triethylamine (0.114 g, 1.13 mmol) and ethyl ch!oroformate (0.049 g, 0.452 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (20 mL) and washed with water (2 x 10 mL) and brine (5 mL), The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification by column chromatography e!uting with 40-60% ethyl acetate/petroleum ether afforded the title compound as an off-white solid (0.04 g, 19%).

The following compounds were prepared In like manner to the procedure outlined in Example 32 :

trans-Trifluoromethyl 2-(2-ch!oro-S-(2,2-dich!oro-3-(3,S- dich!oropheny cyciopropane-i-carboxamido)ben2:ov!)hvdra¾!ne-I-carboxySate (F2543)

Isolated as an off-white solid (0.05 g, 21%).

E ample 33; Preparation of trans- 2 _f 2~dich!oro~/¥-(4~chSoro~3-{«

ffuorobenzyf )hydrazine~l~carbonvf }phenyf )~3~(3 _f 5- (fDcyc!opropane-l-carboxamide CP;

To a 50 mL flask were added irans-2, 2-dlchioro-/V~(4-chioro~3- (hydrazinecarbonyl) phenyl )-3-(3,5-dichlorophenyl)cyclopropane-l-carboxamide

(F2567) (0.10 g, 0,214 mmol), methanol (3 mL) and 4-f!uorobenza!dehyde (0,023 mL, 0.214 mmol). The reaction mixture was stirred at room temperature overnight. The solution was concentrated and the residue purified by column chromatography using 0- 100% ethyi acetate/hexanes as gradient to afford the imine product as a colorless foam. The foam was dissolved in methanol (3 mL) and to the solution were added sequentially sodium borohydride (0.081 g, 1,283 mmol) and acetic acid (0,024 mL, 0,428 mmol). The reaction mixture was stirred overnight at room temperature. Saturated aqueous sodium bicarbonate solution (5 mL) was added carefully to the reaction mixture, and the mixture was extracted with ethyl acetate ( 10 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford the title compound as a colorless foam (0,065 g, 48%).

The following compounds were prepared In like manner to the procedure outlined in Example 33 :

trans- 2, 2~dichSoro~/¥~(4~chloro~3~( 2~{4 _f 4~difS uorocydohexy! )hydra_iine~ 1- carbonvf )phen ~3~{3,5-dichforopheny!)cycfopropane~l~carboxamid8 (F2569)

Isolated as an off-white foam (0.030 g, 22%).

Example 34: Preparation of trans- 2 _f 2-d!chSoro-W-(4-chloro-3-{2-{2 _i 4- diff uoroben.5:y!)hydra-iine-l~carbonyl)pheny!)~3~(3 _f 5~

dichlorophenyS)cyclopropane-l~carboxarnide (F2547)

To a solution of tra ?s-2,2-dichloro-A -(4~chloro-3-(2-(2,4- difluorobenzylidene) hydrazine- 1-carbonyl) phenyl)-3-(3,5-dichlorophenyl)cyclopropane- 1-carboxamide (F3004) (0.20 g, 0.34 rnmoi) in ethanoi (6 mL) were added acetic acid (0, 1 mL) and sodium cyanoborohydride (0.107 g, 1.7 rrsmo!) at 0 °C and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was poured into water (10 mL) and extracted with ethyl acetate (2 x 10 mL), The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification by column chromatography using 20-40% ethyl acetate/petroleum ether as eiuent afforded the title compound as an off-white solid (0, 155 g, 77%),

The following compounds were prepared in like manner to the procedure outlined in Example 34 :

trans- 2 _f 2-Dichloro-W-(4-ch!oro-3-{ 2-( I-phenySethy hy razine- 1- carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l~carboxamide (F254S)

Isolated as an off-white solid (0.175 g, 70%),

trans- 2j2-DichSoro-W-(4-ch!oro-3-(2-(cyc!opropv!r!i ethyl }hydrazine- 1- carbonyl)phenyl)-3-C3,5-dichlorophenyl)cyclopropane-l-

Isolated as an off-white solid (0.085 g, 40%)

frans-2 _f 2-D!chloro-W-(4-ch!oro-3-{2-(3 _f 3 _f 3-tnfSuoropropy Hyd razine-j carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l~ca iide

Isolated as an off-white solid (0.080 g _f 35%).

2,2-Dich!oro-i¥-(4-chioro-3-(2-{ l-methoxypropan-2-yS}hydraxine-I- enyS)-3-(3,5-dich!orophenyt)cyck

Isolated as an off-white solid (0.085 g, 33%).

2 _f 2~DichSoro-W~(4-chforo~3~{l-methyl~2~(3,3 _i 3~triff

enyf )cycSopropane-

Isolated as an off-white solid (0.10 g, 55%) .

^■ Ν~{3~(2~Β>@ηΈγΙ hydraz ne- l-carbonyS )~4~chSorophenvf )~2,2~dichSoro~3~

Isolated as an off-white solid (0.100 g, 28%).

frans-2 _f 2-D!chloro-W-(4-ch!oro-3-{2-(2 _f S-d!fluoroben2:v! razme-I- carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l m!de

Isolated as an off-white solid (0.04 g, 32%) .

Example 35: Preparation of trans-N-(3-(2-Banzylidene

chSoropheny!)-2,2-dichSoro-3-(3 _f 5-dschf 3rophenv'S)cycf

To a solution of fraf?s-2 _f 2-dichloro- V-(4-chlorQ-3-(hydraz!necarbony!)phenyi)-3- (3,5-dich!orophenyi)cyclopropane- l-carboxamlde hydrochloride (F2567) (0.300 g, 0.60 mmol) In ethanoi (8.0 mL) was added sodi um acetate trihydrate (0.099 g, 1.2 mmol) at room temperature and the mixture was stirred for 15 mi n. Benzaidehyde (0.19 g, 1.8 mmo!) was added followed by acetic acid (0.1 mL), and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was poured into water (10 mL) and extracted with ethyl acetate (2 x 10 mL), The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by column chromatography using 20-40% ethyl acetate/petroleum ether as eluent afforded the title compound as a pale brown solid (0.110 g, 35%).

The following compounds were prepared in like manner to the procedure outlined in Example 35:

trans- 2 _r 2-Dichloro-Af-(4-chloro-3-(2-(pyridin-2-ylmethylene)hy drazine-l- carbony!)phen -3-(3,5-dich!orophenyt)cyc!opropane-I-carboxamide (F3002)

Isolated as an off-white solid (0.125 g, 33%).

trans- 2 _j ,2-DichSoro-i¥-(4-ch!oro-3-(2-{2 _i ,5-difSuorobenzy dene}hydra2:sne-i- carbonyl)P^sn -3-(3 _? 5-dich!orophenyS)cyc!opropane-I-carboxamide (F3003)

Isolated as an off-white solid (0.13 g, 34%).

trans- 2 _f 2~DichSoro~i¥~(4~chforo~3~(2~(2 _f 4~difSuorob8nzyfidene)hydrazsne~l~ carbonyf )phen -3-(3 _f S~dichlorophenyS)cyclopropane-l-carbo3 amide (F3004)

Isolated as an off-white solid (0, 105 g, 32%),

trans- 2 _f 2-Dichloro-W-(4-ch!oro-3-{ 2-( I-phenySethy idene)hydra2:!ne- 1- carbony )phenyS)-3-(3 _f S-dich!oropheny cyciopropane-l-carboxamide (F3005)

Isolated as an off-white solid 0.100 g, 38%) .

2 _f 2~DichSoro-i¥~(4-chforo~3 (2~(thiazo ~2~ySmethySene)hydrazine~l- f )phenyt)-3-(3 _f 5-dichi H)cycioprapane-1

Isolated as a paie yellow solid (0.080 g, 30%) .

trans- 2 _f 2-D!chloro-W-(4-ch!oro-3-{2-(cyclopropv!methv!e razine- carbonyf )phenyS)~3~(3 _? 5-dichforopheny!)cycfopropane~l~ca amide (

Isolated as a paie yellow solid (0.100 g, 30%) .

trans- 2,2~Dichloro~i¥-(4~chloro-3~(2~(3,3 _f 3~tnfSuoropropyf!den8)hydra carbony!)phenyS)-3-(3,5-dich!orophenyt)cyc!opropane-I-carbox amide

Isolated as an off-white solid (0.300 g, 40%) .

trans- 2,2-D!chSoro-i¥-(4-ch!oro-3-(2-{propan-2-y!!dene}hydraEsne- i- carbonyl)P^sny -3-(3 _? 5-dich!orophenyS)cyc!opropane-I-carboxamide

Isolated as an off-white foam (0.05 g, 41%),

E ample 36; Preparation of fraiis~2 _f 2~dich!oro~/¥-(4~chSoro~3-{l~m8thyS~2~ (3,3,3-trifluoropropylidene)hydrazine-l-carbonyl)phenyl)-3-( 3 _/ 5- dlchlorophenyli)cyclopropane-i-earboxarnlde (F3009)

To a solution of trans-2-chloro-5-(2,2-dichloro-3-(3,5- dich!orophenyi)cyc!opropane-l-carboxamldo)benzoic acid (C12) (0.50 g, 1.10 mmol) in dichloromethane (10 mL) were added sequentially /V,/V-dimethylformamide (3 drops) and oxaiyl chloride (0.14 mL, 1.66 mmol) at 0 °C, and the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was then concentrated under reduced pressure (bath temperature was maintained at 30-35 °C). The acid chloride was dissolved in dichloromethane (6 mL) and was added to a solution of l-methyl-2-(3,3,3- trifluoropropylidene)hydrazine (C220) (0.600 g (crude)) and triethylamine (0.46 mL, 3.3 mmol) in dichloromethane (10 mL) at 0 °C. The reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was diluted with dichloromethane (20 mL) and washed with water. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. Purification by column

chromatography using 20-40% ethyl acetate/petroleum ether as eiuent afforded the title compound as a pink solid (0.320 g, 50%).

Example 37: Preparation of trans- 2 _f 2-d!chSoro-W-(4-chloro-3- (hydra2:!necarbon l)phenyl)-3-(3 _? S-dichlorophenyl)cyc!opropane-i- carboxamsde hydrochloride (F2567)

To a solution of trans~tert~buty\ 2-(2-chioro-5-(2,2-dichloro~3-(3,5- dicb!oropheny!)cyc!opropane-l-carboxamido) benzoyl) hydrazine- 1-carboxyiate (F2566) (1,00 g, 1.77 mmol) in dichioromethane (10 mL) was added 4 M HCI in l,4~dioxane (5 mL) at 0 °C and the reaction mixture was stirred at 20 °C for 16 hours. The reaction mixture was concentrated under reduced pressure. The residue was triturated with diethyl ether, and the resulting solid was filtered and dried under vacuum. The title compound was isolated as an off-white solid (0.600 g, 68%).

The following compounds were prepared in like manner to the procedure outlined in Example 37:

trans- 2,2-Dich!oro-i¥-(4-chioro-3-(2-methyShydrazine-l-carbonyi}p henv }-3- -dichSoropheny!)cycSopropane-I-carboxamide hydrochloride (F252I)

To a solution of trans-2-chloro-5-(2,2-dlchloro-3-(3,5- dichlorophenyi)cyclopropane-l-carboxamido)benzoic acid (CO) (7.60 g, 16,9 mmol) dichloromethane (200 mL) was added tert-butyl hydrazine carboxylate (2.20 g, 16.9 mmoi) and 3-(((ethyllmino)methyiene) aminoJ-^AZ-dimethylprOpan-l-amine hydrochloride (EDC; 3.20 g, 16.9 mmol). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure and the residue was taken up i n water and extracted with ethyl acetate (2 x 200 mL) . The organic layer was washed with saturated aqueous sodium bicarbonate soi ution (50 mL), dried over anhydrous sodi um sulfate, filtered and concentrated under reduced pressure. Purification by coiumn chromatography eluting with 10% ethyl acetate in petroleum ether afforded the title compound as an off-white solid ( 1.20 g, 22%) .

The following compounds were prepared in like manner to the procedure outlined in Example 38 :

frans-tert-Butyl 2~(2-chloro~5~{ 2,2~dschforo-3~(3 _f 5~

dichiorophenyS)cvciopropane-l-carboxamido}ben2:ov'S }-l-methyShvdrazsne-I- carboxy!ate (F

Isolated as an off-white solid (2.6 g, 78%) .

Example 39; Preparation of 2-ch!oro-S-(C i^ _f 3^)-2 _f 2-dich!oro-3-(3-chloro-4- ffuoropheny cycfopropane-l-carboxamsdol-S-fluoroben-ioic acid (C I)

Step 1 : To a suspension of ( l/?,3K)-2,2-dichloro-3-(3-chloro-4- fluorophenyi)cydopropane- l-carboxyiic acid (€93) (0.445 g, 1.57 mmol) In 1,2- dichloroethane (10 mL) were added two drops of A ,/¥~dimethy!formamide followed by the dropwise addition of oxaiyi dichloride ( 1.992 g, 15,7 mmol), and the resulting light- yellow mixture was stirred at room temperature for 16 hours. The solvent and excess oxaly! dichloride were evaporated under reduced pressure, and the resuiting gold oil was dissolved in 1,2-dlchloroethane ( 10 mL) and concentrated (repeated 2x) to give the intermediate acid chloride as a gold oi l which was used without purification.

Step 2: To a mixture of 5-amino-2-chloro-3-fluorobenzoic acid (C 196) (0.357 g,

1.88 mmoi) and triethyiamine (0.334 g, 3.30 mmol) in 1,2-dichioroethane ( 15 mL) was added a sol ution of the freshly prepared acid chloride, (l ?,3 ?)-2,2-dichloro-3-(3-chioro- 4-fluorophenyl)cyclopropane-l-carbonyl chloride (0,474 g, 1.57 mmol), dropwise at 0 °C, and the resulting green solution was stirred under nitrogen while warming to room temperature over a 1-hour period, and then stirred at room temperature for 3 hours. The reaction mixture was concentrated to a dark oil, and the oii was partitioned between ethyl acetate (100 mL) and 1 normal aqueous hydrogen chloride (25 mL), The phases were separated and the aqueous layer was extracted with additional ethyl acetate (25 mL). The combined organic extracts were washed with brine (50 mL), dried over sodium sulfate, filtered, and concentrated to an amber oil. The oii was dissolved in minimal ethyl acetate and adsorbed to Ce!lte ^® , The adsorbed material was purified by reverse-phase, automated flash chromatography using a gradient of 10-100% acetonitri!e in water as eiuent to give the title compound as a light tan solid (0.398 g, 55%) : mp 205 - 208 °C; ^J H NMR (400 MHz, DMSG- e) δ 13,78 (s, 1H), 11.12 (s, 1H), 7.92 (d, J = 10,8 Hz, 2H), 7.71 (dd, J = 7.1, 1.8 Hz, 1H), 7.54 - 7.39 (m, 2H), 3.59 (d, J = 8.4 Hz, 1H), 3.43 (d, J = 8.4 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO- /e) δ -111.57, -117.24; HRMS-ESI (m/z) [Μ ⁺ Γ calcd for G 7H9CUF2NO3, 452.9305; found, 452.9303.

The following compounds were prepared in like manner to the procedure outlined in Example 39 :

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3~chSoro~4~fSuorophenyl)cvc!opropane~l~ carboMamsdo)-3-f!uorobenzoic acid (C2)

Isolated as a light tan solid (0.740 g, 50%) : mp 186 - 189 °C; *H NMR (400 MHz,

DMSO-de) δ 13.78 (s, 1H), 11.12 (s, 1H), 7.92 (d, J = 10.6 Hz, 2H), 7.71 (d, J = 7.1 Hz, 1H), 7.57 - 7.38 (m, 2H), 3.59 (d, J - 8.4 Hz, 1H), 3.43 (cl, J - 8.5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -111,54, -117.23; ESIMS m/z 454 ([M-Hj ^" ).

trans~5~(2,2~Dichloro-3~(3~chSoro~4-fSuorophenyf )cvclopropane~l~

carboxamsd j}-2-fiuo -3-methySbenTOic acid (C3)

Isolated as a tan solid (1.229 g, 87%) : mp 228 - 235 °C; *H NMR (400 MHz, DMSO-ds) δ 13,25 (s, 1H), 10.76 (s, 1H), 7.99 (dd, J = 6.1, 2.8 Hz, 1H), 7.75 (dd, J = 6.2, 2.8 Hz, 1H), 7.70 (dd, J = 7. 1, 2.0 Hz, 1H), 7.53 - 7 ,40 (m, 2H), 3.56 (d, J = 8.4 Hz, 1 H), 3,39 (d, J = 8.5 Hz, 1H), 2.27 (d, J = 2.1 Hz, 3H) ; ⁱ⁹ F NMR (376 MHz, DMSG- de) δ - 117 ,31,

-120.17; ESIMS m/z 434 ( [M~H] ^~ ) ,

frans-2-Chloro-S-(2 _? 2-d!chlo!O-3-{3-ch!oro-4-fluorophenv! }cvcSopropane-I- carboxamsdo)-3-methv!benz:oic acid (C4)

Isolated as a ! ight-tan solid (0.875 g, 69%) : mp 218 - 222 °C; ^X H NMR (400 MHz, DMSO-c/e) δ 13.42 (s, 1H), 10.84 (s, 1H), 7.90 (d, J - 2.6 Hz, 1H), 7.80 - 7.63 (m, 2H), 7.59 - 7.33 (m, 2H), 3.56 (d, J - 8.4 Hz, 1H), 3.41 (d, J - 8.4 Hz, 1H), 2.38 (s, 3H) ; ⁱ⁹ F NMR (376 MHz, DMSO-tfc) δ - 117,29 ; ESIMS m/z 450 ([M-H]-) .

frans-3-Ch!oro-5-(2,2-dichSoro-3-(3-chSoro-4-fSuorophenvi }cyctopropane-l- carbo3 amsdo)-2-methv'Sbenzoic acid (C5)

Isolated as a tan solid (0.780 g, 63%) : mp 219 - 225 °C; *H NMR (400 MHz, DMSO-de) δ 13.34 (s, 1H), 10.90 (s, 1H), 8.02 (d, J = 2.3 Hz, 1H), 7.96 (d, J = 2.3 Hz, 1H), 7.71 (dd, J ^™ 7. 1, 1.9 Hz, 1H), 7.52 - 7.40 (m, 2H), 3.57 (d, J = 8.4 Hz, 1H), 3.40 (d, J - 8.5 Hz, 1H), 2.49 (s, 3H) ; ¹⁹ F NMR (376 MHz, DMSO-de) δ - 117.29; ESIMS m/z 450 ([M-H] ^" ) .

trans~2~Chioro~5-(2 _f 2-dich!oro~3~{3-ch!oro~4~f!uorophenyf )cyciopropane~l~ carboxamsd j}-3-(tnfiuoromethyS)ben2:oic acid (C6)

Isolated as an off-white solid (0.800 g, 47%): mp 216 - 219 °C; ^l NMR (400 MHz, DMSO-tfc) δ 14,00 (s, 1H), 11.23 (s, 1H), 8.33 - 8,23 (m, 2H), 7.72 (dd, J = 7.1, 1.9 Hz, 1H), 7.56 - 7.39 (m, 2H), 3.60 (d, J = 8.4 Hz, 1H), 3.44 (d, J = 8,5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSG-de) δ -61.39, -117.21; ESIMS m/z 503 ([M-2H] ),

frans-S-{2 _? 2-D!chSoro-3-{3-chSoro-4-fSuorophen¥ cvclopripane-i- carboxamsdo)-3-f!uoro-2-methoxyben2:oic acid (C7)

Isolated as a tan solid (0.760 g, 50%): mp 183 - 186 °C; H NMR (400 MHz, DMSO-cfc) δ 13,28 (s, 1H), 10.91 (s, 1H), 7.93 - 7.78 (m, 1H), 7.78 - 7.66 (m, 2H), 7,47 (d, J - 9.0 Hz, 2H), 3.83 (s, 3H), 3.57 (d, J - 8,4 Hz, 1H), 3,40 (d, J - 8.5 Hz, 1H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -117,29, -128,27; ESIMS m/z 450 ([M-Hj ^" ), frans-3-Ch!oro-5-(2,2-dichSoro-3-(3-chSoro-4-fSuorophenvi}cy cfopropane-l-

Isolated as a tan solid (0.82 g, 48%): mp 217 - 224 °C; ^J H NMR (400 MHz, DMSO-cfc) δ 13.70 (s, 1H), 11.01 (s, 1H), 8,13 (dd, J - 6.1, 2,8 Hz, 1H), 8.06 (dd, J 5.8, 2,7 Hz, 1H), 7,71 (dd, J - 7,2, 1,9 Hz, 1H), 7,54 - 7.38 (m, 2H), 3.59 (d, J - 8,> Hz, 1H), 3.41 (d, J = 8.5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -117.25, -119.42; ESIMS m/z 453

([M-H] ^" ).

frans-5-(2 _f 2-D!ch!oro-3-(3-chloro-4-fluorophenv )cvcSopropane-i- carbGxamsdo)-2,3-dsf!uGrobersTOsc acid (C9)

Isolated as a white solid (0,93 g, 57%): mp 222 - 226 °C; ^"! H NMR (400 MHz, DMSO-ds) δ 11,03 (s, IH), 8.05 - 7.87 (m, 2H), 7.71 (dd, J = 7.1, 1,9 Hz, IH), 7,46 (dd, J = 8.0, 4.1 Hz, 2H), 3.58 (d, J = 8,4 Hz, IH), 3,41 (d, J = 8.5 Hz, IH); ¹⁹ F NMR (376 MHz, DMSO-de) δ -117.26, -135.55 (d, J = 22,4 Hz), -142.67 (d, J = 22.4 Hz); ESIMS m/z 437 ([M-H] ).

frans-3-Chloro-S-(2 _? 2-d!chlo!O-3-{3-ch!oro-4-fluorophenv!}cvcSopropane-I- carboxamsdo)-2~metho3cybenz:oic acid (CIO)

Isolated as a light tan solid (0.380 g, 22%): ^J H NMR (400 MHz, DMSO-de) δ 13.38 (s, IH), 10.91 (s, IH), 8,03 (d, J = 2.7 Hz, IH), 7.90 (d, J = 2.7 Hz, IH), 7.70 (dd, J = 7.1, 2.0 Hz, IH), 7.54 - 7,38 (m, 2H), 3,81 (s, 3H), 3.57 (d, J = 8,4 Hz, IH), 3.40 (d, J = 8.5 Hz, IH); ¹⁹ F NMR (376 MHz, DMSO-de) δ -117.28; ESIMS m/z 466 ([M- H]-).

frans-5-(2 _f 2-D!chloro-3-(3-chloro-4-fluorophenv )cvcSopropane-i- carbo5 amido)~3~ffuoro~2-meth¾flben-5:oic acid (Cll)

Isolated as a white solid (0.304 g, 53%): mp 210 - 212 °C; ¹ H NMR (400 MHz, DMSO-ds) δ 13,26 (s, IH), 10.94 (s, IH), 7.88 (d, J = 2.2 Hz, IH), 7.77 (dd, J = 11.8, 2.1 Hz, IH), 7.70 (dd, J = 7,1, 1.9 Hz, IH), 7.46 (dd, J = 7,8, 4.3 Hz, 2H), 3.57 (d, J = 8.4 Hz, IH), 3.41 (d, J = 8,4 Hz, IH), 2,38 (d, J = 2.0 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ

-114.04, -117.29; HRMS-ESI (m/z) [M ⁺ ] ⁺ caicd for CisHizCisFzNOs, 432,9851; found, 432.9856.

frais~2~ch!oro~5~(2 _J ,2~dschioro~3~(3 _f 5~dichiorophenyf)cyciopropane~l~ carboxamido)benTO!c acid (C12)

Isolated as a !lght brown so!ld (0.421 g, 93%): mp 234 - 236 °C; ^V H NMR (400 MHz, DMSO-ds) δ 13.47 (s, 1H), 10.90 (s, 1H), 8.16 (d, J = 2.3 Hz, 1H), 7.78 (dd, J = 8.7, 2.4 Hz, 1H), 7.59 (m, 4H), 3.56 (dd, J = 49.8, 8.5 Hz, 2H), 1.09 (m, 1H); ¹³ C NMR (101 MHz, DMSO-ds) δ 166.26, 165,77, 162,61, 137,57, 137.27, 134.04, 132.18, 131.44, 131.22, 127.88, 127,66, 126,40, 125.92, 122.88, 121,17, 102.37, 62,11, 38.41, 36,83; ESIMS m/z 454 ([M+H] ⁺ ).

2~Chloro~5~((l ? _f 3?)-2 _J ,2~dschSoro~3~(3 _f 5~dichlorophenyf}cycSopropane~l~ carboxamsdo)benTO!c acsd (C13)

Isolated as a grey solid (3.80 g, 96%): *H NMR (300 MHz, DMSOds) δ 13.48 (s,

1H), 10.90 (s, 1H), 8.15 (d, J = 2.6 Hz, 1H), 7,78 (dd, J = 8.8, 2.7 Hz, 1H), 7.63 (t, J =

1.9 Hz, 1H), 7.57 - 7,50 (m, 3H), 3,62 (d, J = 8.5 Hz, 1H), 3.49 (d, J = 8.5 Hz, 1H);

ESIMS m/z 454 ([M÷H] ⁺ ),

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cvclopropane-i- carbo5amido)ben_ioic acid (C14)

Isolated as a grey solid (3.70 g, 98%): ^l NMR (300 MHz, DMSO-cfe) δ 13,47 (s, 1H), 10.95 (s, 1H), 8.16 (d, 3 - 2.7 Hz, 1H), 7.82 - 7.73 (m, 2H), 7.69 (d, J - 8.3 Hz, 1H), 7.53 (d, J = 8.7 Hz, 1H), 7.43 (dd, J - 8.5, 2.1 Hz, 1H), 3.60 (d, J ^~ 8.5 Hz, 1H), 3.45 (d, J = 8.5 Hz, 1H); ESIMS m/z 454 ([M + H] ⁺ ).

2-ChSoro-5~((ll?,3l)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf)cyclopropane-l- carboMamsdo)benzoic acsd (CIS)

Isolated as a grey solid (3.60 g, 99%); H NMR (400 MHz, DMSO-c/e) δ 13.44 (s, 1H), 10.91 (s, 1H), 8.16 (d, J = 2.7 Hz, 1H), 7.80 - 7.76 (m, 3H), 7,54 (d, J = 8.7 Hz, 1H), 3.63 (dt, J = 8.5, 0,7 Hz, 1H), 3,52 (d, J = 8.5 Hz, 1H); ESIMS m/z 488 ([M+H] ⁺ ). 2-ChSoro-5-((H?,3R}-2j2-dschtoro-3-(3-ch oro-4-fluoropheny!}cv'c!opropane-l- carboxamsdo)ben2:oic acsd (Ci6)

Isolated as a grey solid (3.80 g, 99%): ^l H NMR (400 MHz, DMSO-ce) δ 13,48 (s, 1H), 10.93 (s, 1H), 8,16 (d, J = 2.6 Hz, 1H), 7,78 (dd, J = 8.8, 2.7 Hz, 1H), 7.71 (dd, J - 7,2, 2.0 Hz, 1H), 7.53 (d, J - 8,7 Hz, 1H), 7,50 - 7.42 (m, 2H), 3.58 (d, J - 8.4 Hz, 1H), 3,42 (d, J - 8.5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -117.29; ESIMS m/z 438 ([M + H] ⁺ ).

Example 40: Preparation of cs/trans~3-{3~bromo~4 _f S~difSuorophenyS)~2 _f 2~ dichlorocycSopropane-l-carboxyfic acid (C17)

methoxystyry benzene, /V-Butyllithium (2.5 Molar (M) in hexane) (3.62 mL, 9.05 mmol) was added to a stirred suspension of (4-methoxybenzyi)triphenyiphosphonium chloride (3,79 g, 9,05 mmol) in dry tetrahydrofuran (50 mL) at -30 °C. The resulting heterogeneous dark red mixture was stirred at -25 - -30 °C for 30 minutes, followed by the dropwlse addition of a solution of 3-bromo-4,5-difluorobenzaldehyde (2 g, 9.05 mmol) In anhydrous tetrahydrofuran (5 mL). The resulting suspension of white solid was stirred at -30 °C for another 2 hours, then allowed to warm to ambient temperature and stirred for another 12 hours. The reaction mixture was quenched with water (100 mL) and extracted with diethyl ether (3 x 50 mL), The organic extracts were washed successively with water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under vacuum on a rotary evaporator, Purification by silica gel flash chromatography provided the title compound as a clear colorless oil (1,6 g, 54%, approx. 1 : 1 mixture of E- and Z-stilbenes) : EIMS m/z 325,

Step 2; Preparation of i-bromo-S-{2 _f 2-dsch oro-3-(4'

methoxvphenvl)cyc opropv!)-2 _f 3-d!fiuoroben2:ene. To a stirred solution of (E/Z)-l- bromo-2,3-difluoro-5-(4-methoxystyryl)benzene (1.165 g, 3,58 mmol) and

tetrabutyiammonium hexafiuorophosphate(V) (0.139 g, 0,358 mmoi) In chloroform (28.7 mL) were added sodium hydroxide powder (1,433 g, 35.8 mmol) and water (200 μΙ_) at 23 °C. The resulting mixture was vigorously stirred at 50-55 °C for 16 hours. The reaction mixture was diluted with water and extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated. Purification by silica gel flash column chromatography provided the title compound as a pale yellow oil (1.7 g, 63%, approx. 2 : 1 c/s- to trans-cyciopropanes) : EIMS m/z 325 Step 3, Preparation of c s/irans-S-CS-bromo-^B-dif!uorophenv!)-!,,!- dichforocvdopropane-l-carboxylic acid. Ruthenium(III) chloride hydrate (0.047 g, 0,207 mmoi) was added to a stirred mixture of crude c/s/trans-3-(3-bromo-4,5- difluorophenyl)-2 _f 2-dichiorocyclopropane-l~carboxy!ic acid (1.69 g, 4, 14 mmol) in water: ethyl acetate:acetonltriie (2.5 : 1 : 1, 90 mL) at 23 °C. Sodium perlodate ( 13,29 g, 62, 1 mmol) was carefully added portionwise at a rate to maintain the temperature below 50 °C. The resulting biphasic brown mixture was vigorously stirred at 23 °C for 2 hours. The reaction mixture was diluted with water (200 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated, The residue was dissolved in minima! acetonitriie and purified by C~18 flash chromatography to give the title compound as a grey solid (0.665 g, 44% approx, 2: 1 mixture of trans/cis cyclopropanes) : ¹ H NMR (400 MHz, CDCI3CDCI3) δ 8,90 (s, 1H), 7.42 - 7,21 (m, 1H), 7.10 (dddd, J = 26.8, 9,3, 6.6, 2, 1 Hz, 1H), 3,35 (dd, J = 49.0, 9,6 Hz, 1H), 3,01 - 2.77 (m, 1H); ¹⁹ F NMR (376 MHz, CDC 13) δ -129.47, -129,53, -130, 16, - 130,21, -132,59, -132.64, -133.35, -133.41; ESIMS m/z 345 ([M-H] ^" ).

The following compounds were prepared in like manner to the procedure outlined in Example 4Q :

css/trans-2, 2~DichSoro~3-{3 _f 4~dichloro~5~ff uorophenv!)cycfopropane~l~ ca bonise acid (CIS)

Isolated as a grey solid (0.459 g, 44%, approx. 3 : 1 trans/as) : *H NMR (400 MHz, CDC CDC ) δ 8.73 (s, 1H), 7,20 (d, J = 1.7 Hz, 1H), 7.14 - 6.91 (m, 1H), 3,36 (dd, J = 51,9, 9.6 Hz, 1H), 2.91 (dd, J = 47, 1, 9.6 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -108.55, -109.27; ESIMS m/z 317 ([M~H] ^~ ),

c s/i ^, rans-3-C3-Bromo-5-(pentafluoro-A ⁶ -su!fany )phenyS}-2 _i 2- dich!orocvcSopropane-I-carboxyiic acsd (C19)

Isolated as a grey solid (0.260 g, 40%, approx. 2 : 1 trans/cis) : H IMMR (400 MHz, CDCbCDCb) δ 10,43 (s, 1H), 7.88 (dt, J = 13,2, 1.9 Hz, 1H), 7.75 - 7.48 (m, 2H), 3,61 - 3,29 (m, 1H), 2,96 (dd, J = 38.3, 9,6 Hz, 1H); ESIMS m/z 435 ([M-H] ),

cis/frans-2 _i 2-D!chSoro-3-C3-ch oro-2 _? 4-d!fluorophenv!)cyci ipropane-l- carboxyisc acid (C20)

Isolated as a grey soiid (0.656 g, 35%, approx. 1 : 1 trans/cis) *H NMR (400 MHz, CDCbCDCb) δ 9,27 (s, 1H), 7.35 (q, J = 7,5 Hz, 1H), 7, 11 - 6.90 (m, 1H), 3.33 (dd, J = 104, 1, 9,5 Hz, 1H), 3,06 - 2.77 (m, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -111.34, -111,35, -111.40, -111.41, -112.05, -112,06, -113, 13, -113.14; ESIMS m/z 300 ([M-H] ^" ), c/s/trans~2 _f 2~DichSoro~3~(3~chforo~2~fSuoro~S~

(triffuorom8thyS}phenyl)cyc!opropan8~l-carbo3 ylsc acid (C21)

Isolated as a grey solid (0.485 g, 31%, approx, 2 : 1 trans/cis) : H NMR (400 MHz, CDCbCDCb) δ 9.02 (s, 1H), 7,87 - 7.61 (m, 1H), 7.39 - 7.23 (m, 1H), 3,60 - 3, 19 (m, 1H), 3.14 - 2,85 (m, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62,32, -108.88, -110.51; ESIMS /z 350 ([M-H] ^" ),

Isolated as a green oil (1.42 g, 66%, approx. 3 : 1 trans/cis) : ^l NMR (400 MHz, CDC CDC ) δ 7.33 (dd, J = 21.3, 6.3 Hz, 2H), 6.82 (s, 1H), 3.38 (dd, J = 50,6, 9.7 Hz, 1H), 3.04 - 2.82 (m, 1H), 2.34 (dd, J = 10.0, 2.3 Hz, 3H) ¹⁹ F NMR (376 MHz, CDCb) δ - 61.53, -118.49, -119.16; ESIMS m/z 330 ([M-Hj ^" ),

c/s/trans~3~(3~Bromo~2,5~diffuoropheny!)~2 _? 2-dichforoc¥c!opropane~l~ carboxylic acid (C23)

Isolated as a grey solid (0.545 g, 51%, approx. 1 : 1 trans/cis) : ^j H NMR (400 MHz, CDCbCDCb) δ 9,97 (s, 1H), 7.29 (dtt, J = 7.1, 4.4, 2.3 Hz, 1H), 7.00 (dddd, J = 137.6, 8.2, 5.3, 3.5 Hz, 1H), 3.52 - 3, 10 (m, 1H), 3,07 - 2.74 (m, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ

-112.49, -112.53, -114.36, -114.40, -115.73, -115.77, -116.17, -116.21; ESIMS m/z 345 ([M-H]-).

c/s/trans~2 _f 2~DichSoro~3~{3 _f 4~€lichloro~5~

(triffuorom8thyS}phenyl)cvc!opropan8~l-carbo3 ylsc acid (C24)

Isolated as a tan solid (0.295 g, 25%, approx, 2 : 1 trans/cis) : H NMR (400 MHz, CDCbCDCb) δ 7.71 - 7,45 (m, 2H), 6,48 (s, 1H), 3.38 (dd, J = 62,2, 9.6 Hz, 1H), 2.95 (dd, J = 41.0, 9.6 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -63.01; ESIMS m/z 366 ([M-H] ^" )■ sftrans-l, 2~DichSoro~3-{4~chforo-3~fSuoro~5~

(triffuorom8thyS}phenyl)cvc!opropan8~l-carbo3ylsc acid (C25)

Isolated as a grey solid (0.392 g, 33%, approx, 3:1 trans/ess): *H NMR (400 MHz, CDC CDC ) δ 9.56 (s, 1H), 7,55 - 7.36 (m, 1H), 7.28 (dd, J = 8,8, 2.0 Hz, 1H), 3.41 (dd, J = 59.6, 9.6 Hz, 1H), 2.95 (dd, J = 46.2, 9.6 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62.50,

-109.97, -110.78; ESIMS m/z 350 ([M-H]-).

c/s/trans~2 _? 2-Dich!oro~3~(3,5~dichforo~4~ffuorophenyS}cyclopropane ~l- carboxy!ic acid (C26)

Isolated as a grey solid (0.889 g, 48%, approx.2:1 trans/ess): ^j H IMMR (400 MHz, CDCbCDCb) δ 9,83 (s, 1H), 7.54 - 6.93 (m, 2H), 3,34 (dd, J = 50.9, 9,6 Hz, 1H), 2,89 (dd, J = 46,6, 9.6 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -115.34, -115.98; ESIMS m/z 317 ([M-H] ^" ),

cis/frans-2 _? 2-D!chSoro-3-C3-ch oro-5-(pentaf!uiro-A ⁶ - su!fanyf)pheny!)cycfopropa ~l~carboxy!ic acid (C27)

Isolated as a grey solid (0.412 g, 35%, approx, 3:1 trans/cis): H NMR (400 MHz, CDCbCDCb) δ 7.81 - 7.69 (m, 1H), 7.63 - 7,38 (m, 2H), 5,95 (s, 1H), 3.61 - 3.31 (m, 1H), 3.11 - 2,87 (m, 1H); ESIMS m/z 390 ([M-H] ^" ).

cls/ trans- 2 _? 2-Dich!oro~3~(perffuorophenyi)cycfopropane~l~carboxyii c acid (C28)

Isolated as a white solid (1,44 g, 67%): Ή NMR (400 MHz, CDC ) δ 10.19 (s, 1H), 3.30 (d, J = 8.2 Hz, 1H), 3.09 (d, J = 8,3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCI ₃ ) δ - 140.52, -140.54, -140.58, -140.60, -152.14, -152.20, -152.25, -160.82, -160.84, - 160,87, -160,89, -160.93, -160.95; ESIMS m/z 320 ([M-H] ^" ).

frans-3-(3-Brom 3-4 _f 5-dich 3rophenyS)-2 _f 2-dichi 3rocycSopropar!e-l-carb3xy c add (C29)

Isolated as a white foam (1.3 g, 54%): ^l H NMR (400 MHz, CDCb) δ 7.537.42 (m, 1H), 7.35 (d, J = 2.0 Hz, 1H), 3.41 (d, J = 8.3 Hz, 1H), 2.86 (d, J = 8.2 Hz, 1H). ESIMS m/z 376 ([M-H] ^" ).

trans~3~(4~Bronio~3,5-dichforopheny!)~2,2-dichforocyclopr opane~l~carbo yfic add (C30)

Isolated as a white foam (0,6 g, 29%): *H NMR (400 MHz, CDCb) δ 7.29 (d, J = 0.7 Hz, 2H), 3.39 (d, J - 8.2 Hz, 1H), 2.87 (d, J = 8.3 Hz, 1H). ESIMS m/z 376 ([M-H] ^" ). Example 41: Preparation of trans- 2 _f 2~dich!oro~3~(3~(pentaffuoro~ A ⁶ ~

sulfanyf)pheny!)cycopropane~l~carboxylic acid (C31)

To a round-bottom flask equipped with a magnetic stir bar were added sodium periodate (37,0 g, 0.174 mol), and water (250 mL). Nitrogen was bubbled into the solution for 15 minutes. (3-((l/?,3K)-2,2-Dichloro-3-(4- metboxypbeny!)cyclopropyi)phenyi)pentafluoro- ⁶ -su!fane (C44) (3.7 g, 0.0109 mol) was dissolved in a mixture of ethyl acetate (30 mL)/acetonitrl!e (30 mL) and added to the flask followed by ruthenium chloride (0.150 g, 0.00067 mol). The mixture was stirred for 16 hours. The mixture was diluted with dichloromethane (250 mL), filtered through Celite ^® , and the solid filter cake was rinsed with dichloromethane. The filtrate was transferred to a separatory funnel. The organic layer was separated and the aqueous phase was extracted with dichloromethane (4 x 100 mL). The combined organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Purification by reverse-phase medium performance liquid chromatography (RP- MPLC) using 10-80% acetonitrile/water as eiuent afforded the title compound as a (2.0 g, 51%) : *H NMR (400 MHz, CDCi a) δ 7.76 (d, J - 8.5 Hz, 1H), 7.65 (s, IN), 7.51 (t, J = 8.0 Hz, 1H), 7.44 (d, J = 7.8 Hz, 1H), 3.55 (d, J = 8.3 Hz, 1H), 2.93 (d, J = 8.3 Hz, 1H); ESIMS m/z 358 ([M+H] ⁺ ).

The foi!owing compounds were prepared in like manner to the procedure outlined in Example 41 :

trans- 2 _f 2-Dichloro-3-(4-{pentaf lucres- A ⁶ -suSfany )phenyS)cyc!opropane-I- carboxylic acid (C32)

Isolated as a white powder (2.2 g) : *H NMR (400 MHz, CDC ) δ 7.78 (d, J - 8.7 Hz, 2H), 7.38 (d, J - 8.4 Hz, 2H), 3.53 (d, J - 8.3 Hz, 1H), 2.93 (d, J - 8.3 Hz, 1H); ESIMS m/z 358 ([M÷H] ^~ ),

trans~2,2~Dichloro~3~(3~iodophenyf )cycSopropane~l-carboxy ic acid (C33)

Isolated as a white powder (0.700 g): Ή NMR (400 MHz, CDC ) δ 7.69 (d, J = 7.9 Hz, IH), 7.62 (s, IH), 7.29 - 7.21 (m, IH), 7,12 (t, J = 7.8 Hz, IH), 3.44 (d, J = 8.3 Hz, IH), 2,87 (d, J = 8.3 Hz, IH); ESIMS /z 358 ([M + H] ⁴ ),

trans- 2j2-DichSoro-3-(4-iodophenvl}cyclopropane-l-carboxylic acid (C34)

Isolated as a white powder (1,2 g); ¹ H NMR (400 MHz, CDCb) δ 7,72 (d, J = 8.4 Hz, 2H), 7,01 (d, J = 8.2 Hz, 2H), 3.43 (d, J = 8.3 Hz, IH), 2.85 (d, J = 8,3 Hz, IH); ESIMS m/z 358 ([M+H] ⁴ ).

frans-3-{3 _? S-D!chSorophenv! -2 _f 2-d!fiuorocvcSopropane-I-carboxv c acsd (C35)

Isolated as an off-white solid (0.640 g, 44%): mp 138-142 °C; *H NMR (400 MHz, CDCb) δ 7.34 (t, J ^~ 1.9 Hz, IH), 7.16 (d, J - 1.8 Hz, 2H), 3.47 (ddd, J ^~ 11.9, 7.8, 4.1 Hz, IH), 2.75 (ddd, J = 11.1, 7.9, 1.7 Hz, IH); ¹³ C NMR (101 MHz, CDCb) δ 170.91, 135.50, 133.88, 128,56, 126,74, 109,91 (dd, J = 295.1, 289,3 Hz), 32,62 (dd, J = 11,3, 9.2 Hz), 32.07 (t, J = 11.5 Hz); ¹⁹ F NMR (376 MHz, CDCb) δ -132.28 (d, J = 152,7 Hz),

-132.84 (d, J = 152.8 Hz); ESIMS m/z 267 ([M-H] ^" ).

Example 42; Preparation of trans- 2 _f 2~dichloro~3~(3,5~

dichforophenyl)cycfopropanecarbo3cylsc acid (C36)

Ruthenium(III) chloride (0.080 g, 0.39 mmol) was added to a stirred mixture of trans- l,3-dichloro-5-(-2,2-dichloro-3-(4-methoxyphenyl)cyclopropyl ) benzene (C48) (2,8 g, 7.7 mmol) and sodium periodate (33 g, 160 mmo!) In water: ethyl

acetate: acetonitriie (8 : 1 : 1, 155 mL) at 23 °C. The resulting bi phasic brown mixture was vigorously stirred at 23 °C for 5 hours. The reaction mixture was diluted with water (1000 mL) and extracted with dichloromethane (4 x 200 mL) , The combined organic layers were dried over magnesium sulfate, filtered, and concentrated, The residue was diluted with a sodium hydroxide solution ( 1 , 100 mL) and washed with diethyl ether (4 x 50 mL). The aqueous layer was adjusted to pH 2, using concentrated hydrochloric acid, and extracted with dichloromethane (3 x 50 mL) . The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford the title product as a light brown powder (0.78 g, 34%) ; mp 117 - 120 °C; ^J H NMR (400 MHz, DMSQ-de) δ 13.38 (br s, 1H), 7.52 - 7,65 (m, 3H), 3, 57 (d, J = 8.5 Hz, 1H), 3.50 (d, J = 8.5 Hz, 1H); IR (thin fil m) 3083 (s), 3011 (s), 1731 (s), 1590 (w), 1566 (s), 1448 (w), 1431 (m), 1416 (m) cm ^"1 .

The following compounds were prepared in like manner to the procedure outlined in Example 42 :

frans-2j2-DichSoro-3-(3,4,5-tnch!orophenyl}cyc!opropaneca rboxy ic acid (C37)

Isolated as a yellow powder ( 1.5 g, 39%) : *H NMR (400 MHz, CDCb) δ 7.31 (d, J = 0.7 Hz, 2H), 3.40 (d, J = 8,2 Hz, 1H), 2,86 (d, J = 8.3 Hz, 1H) ; ⁱ³ C N MR (101 MHz, CDCb) δ 171 ,05, 134, 55, 132,44, 131.75, 128.89, 61.18, 39 ,26, 37 , 14; ESIMS m/z 333 ([M-H]-) .

frans-lji-Dichloro-S-fS^-dschloropheny^cycfopropanecarbox ylic acid (€38)

Isolated as a pa!e yellow solid (3.2 g, 51%) : H NMR (400 MHz, CDC 13) δ 7.47 (d, J - 8.3 Hz, IH), 7.37 (d, J - 1.6 Hz, IH), 7.12 (ddd, J - 8.3, 2.1, 0.6 Hz, IH), 3.43 (d, J = 8.3 Hz, IH), 2.86 (d, J - 8.3 Hz, IH); ¹³ C NMR (101 MHz, CDC ) δ 171.52, 132.91, 132.76, 132.29, 130.66, 130.62, 128.02, 61.48, 39.65, 37.13; ESIMS m/z 298 ([M-H] ^" ). trans- 2 _f 2~DichSoro-3~(3~chSoro~5-

(tnf uoromethvOpheny cycfopropanecarboxy c acid (C39)

Isolated as an off-white solid (0.73 g, 28%) : mp 113 - 115 °C; *H NMR (400 MHz, DMSO-ds) δ 13.39 (br s, IH), 7.91 (s, IH), 7.86 (s, IH), 7.84 (s, IH), 3.69 - 3.60 (m, 2H); ESIMS m/z 333 ([M-H]-).

ίΓ3ί 3~2,,2~ΟϊεΗΙθΓθ~3~{3~εΗ!θΓθ~4~ίΙυοΓο Η ηνΙ)ενε1ο Γο 3η6ε3Γ ο ν!ϊε acid (C40)

Isolated as an off-white solid (1.0 g, 53%) : mp 121 - 123 °C; ^J H NMR (400 MHz, DMSO-cfc) δ 13.35 (br s, IH), 7.71 (dd, J = 2.0, 7.2 Hz, IH), 7.53 - 7.35 (m, 2H), 3.50 - 3.41 (m, 2H); ESIMS m/z 281 ([M-H] ^" ).

trans- 2, 2~Dichforo~3~(3~chloro~5-(difSuoromethvf )phenyS)cyclopropane-l~ carboxyisc acid (C4I)

Isolated as an off-white solid (2,6 g, 63%); ^" Ή NMR (300 MHz, CDC ) missing COOH signal δ 7,49 (s, 1H), 7,38 (s, 1H), 7.30 (s, 1H), 6,63 (t, J = 56.0 Hz, 1H), 3.50 (d, J = 8.4 Hz, 1H), 2.91 (d, J = 8.0 Hz, 1H); ¹⁹ F NMR (282,2 MHz, CDCI ₃ ) δ -112.04; ESIMS /z 313 ([M-H] ),

trans- 2 _f 2-D!chloro-3-(4-ch!oro-3-{difluoromethyS}phenv!)cvclop ripane-i- carboxyisc acid (C42)

Isolated as an off-white solid (6,2 g, 69%); *H NMR (400 MHz, CDC ) δ 10,5 (br s, 1H), 7.55 (s, 1H), 7,46 (d, J = 8.0 Hz, 1H), 7.34 (d, J = 8.4 Hz, 1H), 6.95 (t, J = 54,8 Hz, 1H), 3,50 (d, J = 8.4 Hz, 1H), 2.91 (d, J = 8.4 Hz, 1H); ⁱ⁹ F NMR (376.2 MHz, CDC ) δ -115.52; ESIMS m/z 313 ([M-H] ^" },

trans- 2 _J ,2~Dichloro~3~(3~{difSuorometh¾ff)-4~fluoropheny!)cyc fopropane~l~ carboxylic acid (C43)

Isolated as an off-white solid (6.0 g, 77%); *H NMR (400 MHz, CDC!?,) missing

COOH signal δ 7.49 (d, J = 6,0 Hz, 1H), 7,40 (br s, 1H), 7.17 (t, J = 9.2 Hz, 1H), 6,90 (t, J = 54,8 Hz, 1H), 3,49 (d, J = 8,0 Hz, 1H), 2,89 (d, J = 8.4 Hz, 1H); ¹⁹ F NMR (376,2 MHz, CDCb) δ -114.47, -119.69; ESIMS m/z 297 ([M-H] ^" ).

Example 43; Preparation of trans-(3-(2,2-dichloro-3-(4- methox¾fphenyi}cvclopro fane (C44)

To a round-bottom flask equipped with a magnetic stir bar were added (E)- pentafiuoro(3-(4~methoxystyryl)phenyl ⁶ -sulfane (C57) (4.13 g, 0,0123 moi) and benzyl trietnyiammonium chloride (0,6 g, 0,00264 moi). Chloroform (150 mL) was added followed by an ice-cold aqueous solution of sodium hydroxide (20 g, 0.5 moi) dissolved in water (34 mL). The Diphasic mixture was stirred at 40 °C 16 hours. The reaction mixture was cooled to 23 °C, water (100 mL) was added, and the reaction mixture was transferred to a separatory funnel. The organic layer was separated and the aqueous phase was extracted with chloroform (2 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by flash chromatography using 0-15% ethyl acetate/hexane as e!uent gave the title compound as a (3.8 g, 75%) : ^" Ή NMR (400 MHz, CDCb) δ 7.75 (m, 2H), 7.58 - 7.46 (m, 2H), 7.30 (d, J = 8.6 Hz, 2H), 6.95 (d, J = 8,7 Hz, 2H), 3.84 (s, 3H), 3.20 (s, 2H); ESIMS m/z 419 ([M + H] ^~ ),

The following compounds were prepared in like manner to the procedure outlined in Example 43;

frans-(4-(2 _? 2-Dichloro-3-(4-methoxyphenv'!)cycSopropv }phenyS}pentafSuoro- A ⁶ -su!fane (C4S)

Isolated as a white powder (4.0 g) : *H NMR (400 MHz, CDC ) δ 7.75 (d, J - 8.8

Hz, 2H), 7,44 (d, J = 8.4 Hz, 2H), 7.30 - 7.23 (m, 2H), 6.91 (d, J = 8.7 Hz, 2H), 3.81 (s, 3H), 3.21 - 3.08 (m, 2H); ES!MS m/z 419 ([M + H] ),

trans- I-{2,2-Dichtoro-3-{ -methoMV'pheny!)cvcSopropvO-3-!odoben2:ene (C46)

Isolated as a white powder (5,7 g) : ^J H NMR (400 MHz, CDCb) δ 7,73 (s, 1H), 7.68 (d, J = 7.9 Hz, 1H), 7.35 (d, J = 7,7 Hz, 1H), 7,31 - 7.25 (m, 2H), 7, 13 (t, J = 7.8 Hz, 1H), 6,94 (d, J ^: -- 8.7 Hz, 2H), 3.84 (s, 3H), 3.13 (m, 2H) ESIMS m/z 419 ([M + H] ⁺ ). trans- l~{2,2~DichSoro-3~ ~iodophenyf )cyc!opropy!)~4~rnetho5 ybenzene (£47)

Isolated as a white powder (4,0 g) ; H N MR (400 MHz, CDCb) δ 7, 72 (d, J = 8.4 Hz, 2H), 7,29 (m, 2H), 7, 12 (d, J = 8.1 Hz, 2H), 6.93 (d, J = 8.8 Hz, 2H), 3.83 (s, 3H), 3. 11 (in, 2H) ; ESIMS m/z 419 ([M + H] ⁺ ) .

Example 44; Preparation of trans- l,3-dichloro-5-( 2,2-dichloro-3-C4- methoxvphenvl)cyc opropv!)ben2:ene (C48)

Aqueous sodium hydroxide (50%, 6.8 mL, 130 mmoi) was added to a sti rred sol ution of (£)- l,3-dich!orO-5-(4-methoxystyry!)benzene (C61) (2,4 g, 8, 6 mmo!) and /¥~benzyi~/¥,A/-diethy!ethanaminium chloride (0.20 g, 0,86 mmol) in chloroform ( 14 mL, 170 mmol) at 23 °C. The resulting biphasic, dark brown mixture was vigorously sti rred at 23 °C for 24 hours. The reaction mixture was diluted with water (200 mL) and extracted with dichloromethane (2 x 100 mL) . The combined organic layers were dried over magnesium sulfate, filtered, and concentrated to afford the title product as a brown oil (2.8 g, 90%) : *H NM R (400 MHz, CDCb) δ 7.34 (t, J = 1.8 Hz, 1H), 7.21 - 7.30 (m, 4H), 6.93 (m, 2H), 3.83 (s, 3H), 3 , 14 (d, J - 8, 5 Hz, 1H), 3,08 (d, J - 8.5 Hz, 1H); IR (thi n film) 3075 (w), 2934 (w), 2836 (w), 1724 (w), 1640 (w), 1609 (m), 1584 (m), 1568 (s), 1513 (s) cm ^"1 ,

The following compounds were prepared in like manner to the procedure outlined in Example 44 :

trans- I _f 2 _? 3-Tr!chloro-5-{2 _f 2-dsch oTO-3-(4-methoxyphenv!)cvc!oprop¾f benzene (C49)

Isolated as a dark foam (4.7 g, 100%) : *H N MR (400 MHz, CDCb) δ 7.40 (cl, J = 0.6 Hz, 2H), 7.29 - 7,22 (m, 2H), 6,96 - 6.89 (m, 2H), 3.83 (s, 3H), 3.12 (d, J = 8.8 Hz, 1 H), 3.06 (d, J = 8,7 Hz, 1H) ; ¹³ C NMR ( 101 MHz, CDCb) δ 159.46, 135.08, 134.23, 130.91, 129.85, 129.16, 125,42, 114,02, 64.67, 55.32, 39, 62, 38 ,48,

trans- l,2-D!ch!oro-4-(2,2-dschSoro-3-(4-methoxyphenyi}cycfopropy )benzer!e (CSO)

Isolated as an orange-red oil (7,6 g, 99%): ^L H NMR (400 MHz, CDCb) δ 7,47 (d, J = 4,9 Hz, 1H), 7,45 (bs, 1H), 7.30 - 7.23 (m, 2H), 7.21 (dd, J = 8.2, 1.9 Hz, 1H), 6.96 - 6.90 (m, 2H), 3.83 (s, 3H), 3.11 (app. q, J = 8.8 Hz, 2H); ¹³ C NMR (101 MHz, CDCb) δ 159.39, 134.90, 132.62, 131.99, 130,90, 130.40, 129.90, 128.33, 125.81, 113.98, 64.94, 55.33, 39.52, 38.75.

f ^, ra«s-l-Ch oro-3-(2,2-d!ch!oro-3-{4-methoMV'pheny!)cvdopropv'S}-S- (dsf!uoromethyi}benze

Isolated as a yellow liquid (11.5 g, 69%): H NMR (300 MHz, CDCb): δ 7,47 (s, 2H), 7.39 (s, 1H), 7.28 (d, J = 8.7 Hz, 2H), 6.93 (d, J = 8,7 Hz, 2H), 6,64 (t, J = 56.1 Hz, 1H), 3.83 (s, 3H), 3.16 (q, J = 8.7 Hz, 2H),

frans~l~Chforo~4-(2, 2~dichforo~3-(4~methoxyphenvl)cycfopropyf)~2- (dsf!uoromethyl) benzene (C52)

Isolated as a pa!e yellow solid (10.7 g, 83%): *H NMR (400 MHz, CDCb) δ 7.65 (s, IN), 7.46 - 7.41 (m, 2H), 7.28 (d, J = 8.4 Hz, 2H), 7.10 - 6.83 (m, 3H), 3.83 (s, 3H), 3.18 - 3.13 (m, 2H).

fraiis~4~(2 _f 2~Dichforo~3~(4~methoxvphenvf}cycSopropyf)~2-{difluoromethyf )~l~ ffuorobenzene (CS3)

Isolated as an off-white solid (10,0 g, 55%); ESIMS m/z 374 ([M + H] ⁺ ).

trans- l~Chforo~3~(2 _f 2~dichSoro-3-{4~methoxvphenyf)cvdopropvl)-5- (trifuoromethvObenze

Isolated as a brown soild (4,0 g, 74%); *H NMR (300 MHz, CDC ) δ 7,64 (s, 1H), 7.45 (s, 1H), 7,42 (s, 1H), 7,26 (d, J = 9,0 Hz, 2H} _; 6,93 (d, J = 9.0 Hz, 1H), 3.83 (s, 3H), 3.15 - 3.05 (m, 2H); ESIMS m/z 395 ([M + H] ⁺ ),

frans~2~Chforo~4-(2,2~dichloro~3~(4~metho5yphenyf)cydopro pyS}~l~

fuorobenzene (C5S)

Isolated as a brown liquid (2.0 g, 58%); ESIMS m/z 345 ([M + H] ⁺ ).

Example 45: Preparation of trans- l _J ,3~dichSoro~5~(2 _f 2~diffuoro~3~(4~

methoxyphenyl)cyc opropyf)benzen8 (CS6)

(E)-l,3-Dichloro-5-(4-methoxystyryl)benzene (C6I) (1.5 g, 5,4 mmoi) was dissolved in tetrahydrofuran (10 ml_) in a 25 mL microwave vial.

Trimethy!(trifluoromethyl)siiane (3.8 g, 26.9 mmo!) and sodium iodide (0.81 g, 5,4 mmoi) were added and the capped vial was heated in the microwave at 85 °C for 1 hour. The vial was vented with a needie and analysis of an aliquot by *H NMR spectroscopy indicated approximately 20% conversion. Additional trimethyl(trifluoromethyl)silane (7,2 g, 54 mmoi) and sodium iodide (0,56 g, 3,8 mmoi) were added, and the mixture was heated in the microwave at 110 °C for 8 hours. Further analysis of an aiiquot by ^J H NMR spectroscopy indicated complete conversion with some decomposition. The reaction mixture was partitioned between ethyi acetate and saturated sodium chloride solution, the layers were separated, and the organic phase was dried over sodium sulfate, Filtration and concentration gave the product as a brown oil (1.8 g, 100%) : ^l H NMR (400 MHz, CDCI ₃ ) δ 7.30 (t, J = 1.9 Hz, 1H), 7.25 - 7.19 (m, 4H), 6,93 - 6.88 (m, 2H), 3.82 (s, 3H), 2.97 (q, J = 7,8 Hz, 1H), 2,88 (q, J = 7.6 Hz, 1H); ⁱ⁹ F NMR (376 MHz, CDCIs) δ -133.89; EIMS m/z 329.

Example 46: Preparation of {El-pentafluoroCS-C^metho ystyr O heny )^ ⁵ - suSfane (CS7)

A flame-dried round-bottom flask equipped with a magnetic stir bar was purged with nitrogen. Potassium fert-butoxide (0,55 g, 0.0049 mol), 18-crown-6 (0,2 g,

0.00076 mol) and tetrahydrofuran (20 mL) were added. The suspension was cooled to 5 °C. 3-(Pentafluorothio) benza!eiehyeie (0.8, 0.00345 mol) and diethyl (4- methoxybenzyl)phosphonate (1.16 g, 0.00449 mol) were dissolved In tetrahydrofuran (4 mL) and added to the above suspension over 15 minutes. The internal temperature did not exceed 8 °C during the addition. The reaction mixture was warmed to 23 ^C C over 30 minutes and then heated at 50 °C for 4 hours. The reaction was concentrated under reduced pressure. Water (100 mL) and methyl tert-butyi ether (MTBE; 100 mL) were added. The organic layer was separated and the aqueous phase was extracted with MTBE (2 x 75 mL). The combined organic layers were washed with brine (75 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Purification by flash chromatography using 0-15% ethyl acetate/hexane as eiuent provided the title compound as an off-white solid (0,85 g, 73%) : H NMR (400 MHz, CDC ) δ 7.84 (s, 1H), 7.64 - 7.56 (m, 2H), 7.47 (d, J = 8.7 Hz, 2H), 7.42 (t, J = 8,0 Hz, 1H), 7, 11 (d, J = 16,3 Hz, 1H), 7,02 - 6.86 (m, 3H), 3.84 (s, 3H); ESIMS m/z 337 ([M + H] ⁺ ).

The following compounds were prepared In like manner to the procedure outlined in Example 46 :

(£)~Pentaffuoroi4~(4~methoxystyryS)phenyl)~A ⁶ ~suSfane (CSS)

Isolated as a white powder (3.7 g 70%) : Ή NM R (400 MHz, CDCb) δ 7.71 (d, J 8.8 Hz, 2H), 7.53 (d, J = 8.5 Hz, 2H), 7.48 (d, J = 8.7 Hz, 2H), 7.14 (d, J = 16,3 Hz, 1H), 7.01 - 6,87 (m, 3H), 3,85 (s, 3H) ; ESIMS m/z 337 ([M + H] ⁺ ) .

(E}-l-Iodo-3-(4-methoxvstyryt }benxene {€59)

Isolated as a white powder (5.3 g 91%) : *Η NM R (400 MHz, CDCb) δ 7.85 (s, 1H), 7.55 (d, J = 7,8 Hz, 1H), 7,45 - 7.41 (m, 3H), 7.09 - 7.02 (m, 2H), 6.91 (d, J = 8.8 Hz, 2H), 6.85 (d, J - 16.3 Hz, 1H), 3.84 (s, 3H) ; ESIMS m/z 337 ([M + H]-) .

(£)~l~Iiodo~4-(4~methoMystyryf )benzene (C60)

Isolated as a white powder (3.3 g 94%) : *H NM R (400 MHz, CDCb) δ 7.66 (d, J 8.4 Hz, 2H), 7.44 (d, J = 8.7 Hz, 2H), 7.22 (d, J = 8,4 Hz, 2H), 7,06 (d, J = 16,3 Hz, 1H), 6.94 - 6.83 (m, 3H), 3.83 (s, 3H) ; ESIMS m/z 337 ([M + H] ⁺ ) .

Example 47: Preparation of {E}~l _f 3~dichloro~5-(4~methoxvstyryf )benzene (CC

Sodi um methoxide powder (98%, 0.63 g, 11 mmol) was added to a stirred sol ution of 3,5-dichlorobenzaidehyde (2.0 g, 11 mmol) and diethyl 4- methoxybenzyl phosphonate (2.0 mL, 11 mmol) i n dry /V,/V~dimethylformamide (38 mL) at 23 °C. The resulting heterogeneous dark blue mixture was heated to 80 °C, resulting in a dark brown mixture, and stirred for 24 hours. The cooled reaction mixture was diluted with water (500 mL) and extracted with diethyl ether (3 x 100 mL) . The combined organic layers were dil uted with hexane ( 150 mL) and washed with water (300 mL) . The organic layer was dried over magnesium sulfate, filtered, and concentrated to afford the title product as a l ight brown oil (2.4 g, 75%) : ^l NMR (400 MHz, CDCb) δ 7.44 (m, 2H), 7,34 (d, J = 2 Hz, 2H), 7, 20 (t, J = 2 Hz, 1H), 7.06 (d, J = 16, 5 Hz, 1H), 6.91 (m, 2H), 6.82 (d, J = 16.5 Hz, 1H), 3.84 (s, 3H); IR (thin film) 2934 ( ), 2835 (w), 1724 (w), 1637 (w), 1605 (m), 1581 (m), 1558 (m), 1511 (s) cm ¹ .

The following compounds were prepared in like manner to the procedure outlined In Example 47:

(£)-l _? 2,3-TnchSoro-5-(4-!T!ethoxystvryl)benEene (C62)

Isolated as an off-white solid (3.7 g, 31%) : H NMR (400 MHz, CDC ) δ 7.49 - 7.46 (m, 2H), 7.47 - 7.39 (m, 2H), 7.04 (cl, 3 - 16.3 Hz, 1H), 6.93 - 6.89 (m, 2H), 6.78 (d, J - 16.3 Hz, 1H), 3.84 (s, 3H); "C NMR (101 MHz, CDCb) δ 159.46, 135.08, 134.23, 130.91, 129.85, 129.16, 125.42, 114,02, 64.67, 55.32, 39.62, 38.48; E!MS m/z 313 cmn,

(£}-I _f 2-D!chSoro-4-(4-methoxystyryt)benzene (C63)

Isolated as an off-white solid (6.0 g, 53%) : mp 91 - 94 °C; NMR (400 MHz, CDCb) δ 7,56 (d, J = 2.0 Hz, 1H), 7.46 - 7,42 (m, 2H), 7,39 (d, J = 8.4 Hz, 1H), 7.29 (dd, J = 8.4, 2.1 Hz, 1H), 7.04 (d, J = 16.2 Hz, 1H), 6.93 - 6.88 (nrt, 2H), 6.85 (d, J = 16.3 Hz, 1H), 3.84 (s, 3H); ¹³ C NMR ( 101 Hz, CDCb) δ 159.75, 137.86, 132.72, 130,58, 130.49, 130.12, 129.33, 127.96, 127.77, 125,37, 123,98, 114,24, 55.35; EIMS m/z 279 ([ΜΓ).

(£)-l~ChSoro-3~(4~methoxvstyr¾fl)-5~{trifluoromethyf }benz:ene (C64)

Isolated as an off-white solid (4,3 g, 58%) : Ή NMR (300 MHz, CDC 13) δ 7.62 (s, 1H), 7.58 (s, 1H), 7,48 - 7.42 (m, 3H), 7.12 (d, J = 16,2 Hz, 1H), 6,95 - 6.85(m, 3H), 3.84 (s, 3H); ESIMS m/z 313 ([M+H] ),

(E}-2-Bromo-l _f 3-dichSoro-5-(4-methoxvstyry!}benxene (C65)

Isolated as an off-white solid (2.8 g, 40%) : *Η IMMR (300 MHz, CDCI ₃ ) δ 7.46 (s, 2H), 7.43 (d, 3 - 9.0 Hz, 2H), 7.07 (d, J = 13.5 Hz, 1H), 6.90 (cl, J - 9.0 Hz, 1H), 6.73 (d, J - 13.5 Hz, 1H), 3.84 (s, 3H) ; ESIMS m/z 358 ([M + H] ⁺ ) .

{E)~2~Chforo~ l-f!uoro-4~ ~methoxystyryf )benzene (C66)

Isolated as an off-white solid (6.0 g, 72%) : ESIMS m/z 263 ([M+ H] ⁺ ),

Example 48: Preparation of (E)~l _f 3~dichloro~2-ff uoro~5~(4- methoxystyry!)benzene

A stirred mixture of 5-bromo- l,3-dichloro-2-fluorobenzene (2.00 g, 8.20 mmoi), l-methoxy-4-vi nylbenzene ( 1.32 g, 9.80 mmoi), and triethylamine (20 mL) under argon was degassed for 5 minutes. Pa!ladium(II) acetate (0.0368 g, 0.164 mmoi) and 1, 1 '- bis(di phenyl phosphlno)ferrocene (0.181 g, 0.328 mmoi) were added and the reaction was heated to 90 °C for 16 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, and concentrated . Purification by flash column chromatography provided the title compound as an off-white solid ( 1.60 g, 67%) : ^" Ή NMR (300 MHz, CDC 13) δ 7.41 (d, J - 8.8 Hz, 2H), 7.31 (s, 1H), 7.37 (s, 1H), 6.96 (d, J = 16.0 Hz, IN), 6.89 (d, J = 8.8 Hz, 2H), 6.76 (d, J = 16.0 Hz, 1H), 3.84 (s, 3H) ; ESIMS m/z 297 ([M + H]÷) .

Example 49: Preparation of (E}~3~chSoro-5~(4~methoxystyryi ) benzaidehyde (C68)

To a stirred solution of 3-bromo-5-chlorobenzaldehyde (20.0 g. 91.32 mmoi) in dimethyiacetamide, l-methoxy-4-vinyl benzene ( 18.3 g, 136.9 mmoi) and triethyiamine (50mL _f 273.96 mmoi) were added, and the reaction mixture was degassed with argon for 5 minutes. Pailadium(II) acetate (410 mg, 1.83 mmoi) and tri-o-toiyiphosphi ne ( 1.11 g, 3.65 mmoi) were added, and the resulting reaction mixture was heated to 100 °C for 16 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The combined organic layer was dried over sodium sulfate and concentrated under reduced pressure. The resulting crude material was purified by flash column

chromatography using 5- 10% ethyl acetate in petroleum ether as the eiuent to afford the title compound as a yel low solid ( 13.5 g, 54%) ; ^'! H NMR (300 M Hz, CDCIs) δ 9.99 (s, 1H), 7.85 (s, 1H), 7.69 (s, 2H), 7,47 (d, J = 8.4 Hz, 2H), 7.16 (d, J = 16,2 Hz, 1H), 6,94 (t, J = 8,4 Hz, 3H), 3,84 (s, 3H) ; ESIMS /z 273 ([M + H] ⁴ ) ,

The following compounds were prepared in like manner to the procedure outlined in Example 49:

(£)-2~ChSoro-5~{4~methox¾fstyr¾fl )benzafdehyde (€69)

Isolated as a pale yellow solid ( 11.8 g, 27%) : H NMR (300 M Hz, CDC ) δ 10.45 (s, 1H), 8.02 (s, 1 H), 7.62 (d, J - 6.4 Hz, 1H), 7.46 - 7.40 (m, 3H), 7. 12 (d, J - 16.4 Hz, 1 H), 6.95 - 6.90 (m, 3H), 3.95 (s, 3H) ; ESIMS m/z 273 ([M + H] ⁴ ) ,

(ff}-2-Fluoro~S~(4-rnetho ystvryl)ben¾aSdehyde (C70)

Isolated as an off-white solid (0.25 g, 20%) ; ^J H NMR (400 MHz, CDC 13) δ 10.43 (s, 1H), 7.90 (d, J - 8.4 Hz, 1 H), 7.54 - 7.46 (m, 4H), 7.20 (d, J - 16.0 Hz, 1H), 6.94 6.90 (m, 3H), 3.85 (s, 3H) ; ESIMS m/z 274 ([M + H] ⁺ ) . E ample 50; Preparation of (£ ^' )~l-ch!oro~3~{diffuoromethyS)~S~{4~metho y- styryl)ber«ene (C71)

To a stirred solution of (£)-3~chioro~5-(4~methoxystyryl) benzaidehyde {€68} (13 g, 47,79 rnmoi) in dichloromethane ( 130 mL) was added diethyiaminosulfur trifluoride (31.5 mL, 238.97 mmoi) at -78 °C. The resulting sol ution was stirred for 20 hours at room temperature. The reaction mixture was cooled to 0 °C, and a sol ution of saturated aqueous sodium bicarbonate was added dropwise. The layers were separated and the aqueous layer was extracted with dichloromethane (3 x 75 mL) . The combi ned organic layer was washed with water and brine, dried over sodium sulfate, and concentrated . The crude material was purified by flash column chromatography using 10-20% ethyl acetate in hexanes as the eluent to afford the title compound as a pale yellow oil (13.1 g, 94%) : H NMR (400 MHz, CDC ) δ 7.55 (s, 1H), 7,45 (d, J = 8.8 Hz, 3H), 7.34 (s, 1H), 7, 10 (d, J = 16 Hz, 1H), 6.90 (t, J = 8.4 Hz, 3H), 6.61 (t, J = 56,4 Hz, 1H), 3.80 (s, 3H) ; ¹⁹ F N MR (376 MHz, CDCb) δ - 111.72.

The following compounds were prepared In like manner to the procedure outlined in Example SO :

(ff)~l-ChSoro~2~{difSuoroniethvl }~4~(4~m8thoxvstyrvl }benzen8 (C72)

Isolated as an off-white solid ( 12 g, 94%) : ^J H N MR (300 MHz, CDCb) δ 7.75 (s, 1H), 7.51 - 7,44 (m, 3H), 7,37 (d, J = 8.4 Hz, 1H), 7.13 (d, J = 6.6 Hz, 1H), 7 ,06 (s, 1H), 6.95 - 6,89 (m, 3H), 3,95(s, 3H); ⁱ⁹ F NMR (282 MHz, CDCb) δ - 115,31 ; ESIMS m/z 295 ([M + H] ⁴ ) ,

-2-(Dsf!uoromethv )-l-flu 3ro-4-(4-methoKystyryl)benzene (C73)

Isolated as an off-white solid (14,0 g, 70%) ; H N R (300 MHz, CDCI ₃ ) δ 7,69 (d, J = 9.0 Hz, 1H), 7.57 - 7.53 (m, 1H), 7,45 (d, J = 9.9 Hz, 2H), 7.13 - 7.06 (m, 2H), 7.00 - 6.89 (m, 4H), 3.85 (s, 3H); ESIMS m/z 279 ([M + H] ⁺ ).

Example 51: Preparation of trans- 2,2-dichloro-3-(3,5-dichlorophenyl)cyclo- propane carboxyisc acid (C3

Sodium permanganate (40% aqueous) (84 g, 236 mmol) was added dropwise to a stirred mixture of trans-2,2-dichloro-3-(3,5-dichlorophenyl)cydopropane-l- carbaldehyde (C79) (58.7 g, 196 mmol) in acetone (982 mL) at 15 °C. The resulting mixture was stirred at 20 °C for 2 hours. The reaction mixture was diluted with isopropyi alcohol (20 mL) and concentrated to remove the acetone, Celite ^® and aqueous hydrochloric acid (1 N, 295 mL, 295 mmol) were added to the brown residue. The resulting mixture was diluted with ethyl acetate (500 mL) and filtered through Celite ^® . The filtrate was washed with brine (200 mL). The organic layer was dried over sodium sulfate, filtered and concentrated. The resulting slurry was diluted with heptane (~200 mL) and allowed to solidify at 20 °C. The solid was collected, washed with heptane and dried to afford the title product as a white solid (54,68 g, 91%) : ^ NMR (300 MHz, CDCh) δ 7.36 (t, J = 1.9 Hz, 1H), 7, 17 (dd, J = 1.9, 0.7 Hz, 2H), 3.48 - 3.37 (m, 1H), 2.87 (d, J = 8,3 Hz, 1H); ¹³ C NMR (400 MHz, CDC ) δ 135.44, 135.28, 128.66, 127.30, 39,68, 36.88; ESIMS m/z = 298,9 ([M-H]) ^" ,

The following compounds were prepared In like manner to the procedure outlined in Example SI :

frai s~2 _J ,2~Dichloro~3~(3 _J ,4 _f 5~trichforophenyS}cycfc5propane-l-carbo5 ySic acid (C37)

Isolated as a white solid (2,78 g, 95%) ; *H NMR (400 MHz, DMSO-de) δ 13.41 (s, 1H), 7,81 (d, J = 0.6 Hz, 2H), 3.62 (d, J = 8.6 Hz, 1H), 3.52 (d, J = 8,6 Hz, 1H); ESIMS /z 332 ([M-H] ^" ), fraiis~2 _f 2~DichSoro~3~(3 _f 4~dich!orophenyS}cvcfopropan8~l~carbo3ylsc acid (C38)

Isoiated as a white soiid (124 g, 82%): mp 133 - 135 °C: *H NMR (500 Hz, DMSO-A) δ 13,39 (s, 1H), 7,76 (d, J = 2,0 Hz, 1H), 7,64 (d, J = 8.3 Hz, 1H), 7.44 (dd, J - 8.4, 2,1 Hz, 1H), 3,49 (s, 2H), ⁱ³ C NMR (126 MHz, DMSO-ds) δ 166.34, 133.35, 130,47, 130,33, 130.09, 129.77, 128.81, 61.43, 37,00, 36.06.

trans- 2 _f 2~DichSoro-3~{3~chSoro~4~fSuorophenyf)c¥c!opropane~l~carbox yfic acid (C40)

Isolated as a white solid (165 g, 71%): *H NMR (400 MHz, CDCb) δ 11.57 (s, 1H), 7.42 (dd, J = 8.2, 7.6 Hz, 1H), 7.11 - 6,98 (m, 2H), 3.46 (d, J = 8.2 Hz, 1H), 2.85 (d, J = 8.3 Hz, 1H); ⁱ⁹ F NMR (376 MHz, CDCb) δ -114.07; ESIMS m/z 282 ([M-H] ^~ ) ^■

In another preparation, isolated as a white powder (10,385 g, 77%): 119-121 °C; ^l NMR (400 MHz, CDCb) δ 11.83 (s, 1H), 7.32 (d, J = 6.9 Hz, 1H), 7.16 (d, J = 6,7 Hz, 2H), 3.45 (d, J = 8,3 Hz, 1H), 2,85 (d, J = 8.3 Hz, 1H); ⁱ³ C NMR (101 MHz, CDCb) δ 172.18, 159.26, 156.77, 130.95, 129,26, 129,22, 128.57, 128.50, 121.52, 121.34, 116.94, 116.73, 61.59, 39,64, 37.30; ⁱ⁹ F NMR (376 MHz, CDCb) δ -115.16; ESIMS m/z 281 [(M-H]-).

trans~3~(4~Bromo~3~{trifluoromethyf)phenyS)~2 _f 2~dichlorocycSopropane~l~ carboxy!sc acid (C74)

Isoiated as a white solid (1.21 g, 51%): ^l H NMR (400 MHz, CDCb) δ 10.87 (s, 1H), 7.74 (d, J = 8.3 Hz, 1H), 7.58 (d, J = 2.2 Hz, 1H), 7.30 (dd, J = 8,3, 2.2 Hz, 1H), 3.49 (d, J = 8.3 Hz, 1H), 2.91 (d, J = 8,3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62,77, - 62.78; ESIMS m/z 377 ([M-H] ^" ), trails- 2 _f 2~DichSoro-3~(4~chSoro~3-{tr!fSuoromethyf )phenyS}cycfoprop

carbo yiic acid (C75)

Isolated as a white solid (2,02 g, 43%) : Ή NMR (400 MHz, CDC ) δ 7.96 - 7,51 (m, 3H), 7.39 (dd, J - 8.3, 2.2 Hz, 1H), 3.50 (d, 3 - 8.3 Hz, 1H), 2.90 (d, 3 = 8.3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62.75, -62.75; ESIMS m/z 332 ([M-H] ).

trans- 2j2-DichSoro-3-(4-f!u jro-3-(tr!f uoromethyS}phenyi}cycfopropane-l- carboxyi c acid (C76)

Isolated as a white solid (3.08 g, 67%) : *H NMR (400 MHz, CDCb) δ 8.18 (s, 1H), 7.64 - 7.39 (m, 2H), 7.24 (t, J = 9.3 Hz, 1H), 3.50 (dd, J = 8,4, 1.0 Hz, 1H), 2.89 (d, J = 8,3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -61,48, -61.51, -114,23, -114.26, -114.29; ESIMS m/z 316 ([M-H] ).

trans- 2 _f 2-D!chioro-3-(3-f!u iro-5-(t!if uoromethyi)pheny!)cyciopropane-I- carboxy!ic acid (C77)

Isolated as a white solid (3.7 g, 55%) : *H NMR (400 MHz, CDCb) δ 11 ,40 (s, 1H), 7.42 - 7,27 (m, 2H), 7.20 (dt, J = 8,9, 2.0 Hz, 1H), 3.53 (d, J = 8,3 Hz, 1H), 2,93 (d, J = 8,3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62,86, -109,49; ESIMS m/z 316 ([M-H] ). frans-3-(3-Bromo-S-{tr!fiuoromethy P^snyi)-2 _? 2-dichiorocyciopr ipane-i- carboxyisc acid (C78)

Isolated as a tan solid (0.375 g, 31%) : ^X H NMR (400 MHz, CDCb) δ 10.52 (s, 1H), 7.77 (s, 1H), 7.62 (d, J = 1.8 Hz, 1H), 7.46 (s, 1 H), 3.52 (d, J = 8.2 Hz, 1H), 2.93 (d, J = 8.3 Hz, 1H) ; ¹⁹ F NMR (376 MHz, CDC ) δ -62.84; ESIMS m/z 377 ([M-H] ^~ ) .

Example 52: Preparation of trans- 2,2~€ΐ!€Η!θΓθ~3~(3,5~€ϊεΗΙο^ Η8πν!}ενεΙο~ propane~l~carbaldehyde (€

Aqueous hydrochloric acid (2 N, 237 mL) was added to a stirred solution of 1 ,3- dichloro-5-((frans-2,2-dichloro-3-(diethoxymethyl)cyclopropy l)benzene (C83) (85.7 g, 227 mmol) in acetonitrile ( 1184 mL) . The mixture was stirred at 20 °C for 16 hours. The resulting mixture was diluted with water (200 mL) and concentrated to remove the acetonitrile. The resulting aqueous mixture was extracted with hexanes (600 mL) , The organic layer was washed water (300 mL), dried over anhydrous sodi um sulfate, filtered and concentrated. The crude product was purified by flash column chromatography using 0-20% ethyl acetate/nexanes as eiuent to afford the title product as a yellow oil (58.7 g, 86%, purity 95%) : ^l N MR (400 MHz, CDCb) δ 9.54 (d, J = 4.0 Hz, 1H), 7.46 - 7.09 (m, 3H), 3.51 (d, J = 8, 0 Hz, 1H), 2,92 (dd, J = 8,0, 4, 0 Hz, 1H); ¹³ C N MR (126 MHz, CDCb) δ 193,41, 135,33, 135.09, 128.78, 127 ,34, 42,89, 39,31; IR (thin film) 3078, 2847, 1714, 1590, 1566, 1417, 1387.

The following compounds were prepared In like manner to the procedure outlined in Exampie 52 :

frans~2 _i 2~Dichloro~3~(3 _i 4~dschSorophenyl)cycfopropane~l~carbaSdehyde (C80)

Isolated as orange oil (143 g, 98%) ; H N R (400 MHz, CDCb) δ 9, 53 (d, J = 4.1 Hz, 1H), 7,47 (d, J = 8.3 Hz, 1H), 7.37 (dd, J = 2,2, 0.7 Hz, 1H), 7.12 (ddd, J = 8,3, 2.2, 0.7 Hz, 1H), 3.51 (dd, J = 7.9, 0,8 Hz, 1H), 2.90 (dd, J = 8.0, 4, 1 Hz, 1H).

trans- IjZ-DichSoro-S-CSj^B-tnch!oropheny^cyc!opropane-l-carbaSdehy de (C8I)

Isolated as a yellow solid (2.8 g, 69%) : *H NMR (400 MHz, CDCb) δ 9,55 (d, J - 3.9 Hz, 1H), 7.30 (d, J - 0.7 Hz, 2H), 3.48 (elt, J - 8,0, 0.8 Hz, 1H), 2.92 (dd, J - 7,9, 3.9 Hz, 1H).

trans~2,2~Dichloro~3~(3~ch!oro~4~fluoroph8nyf )cycSopropane~l-carbafdehyde

Isolated as orange oil (230 g, 97%) : *H NMR (300 MHz, CDCb) δ 9.52 (d, J - 4,2 Hz, 1H), 7.36 - 7.30 (m, 1H), 7.19 - 7, 16 (m, 1H), 7.15 (d, J = 1,2 Hz, 1H), 3, 51 (dt, J = 7,9, 0.7 Hz, 1H), 2.88 (dd, J = 7,9, 4.2 Hz, 1H),

In another preparation, isolated as a yellow oil (12,496 g, 71%) : ^J H NMR (400 MHz, CDC ) δ 9.52 (d, J = 4.1 Hz, 1H), 7.33 (d, J = 7,2 Hz, 1H), 7, 16 (dd, J = 6.8, 1.0 Hz, 2H), 3,53 (d, J - 7.9 Hz, 1H), 2.90 (dd, J - 7,9, 4, 1 Hz, 1H); ¹³ C NMR (101 MHz, CDCb,) δ 193.77, 159.27, 156.78, 131.03, 129.04, 129,00, 128,66, 128.59, 121.49, 121,31, 116,95, 116,74, 61.68, 43.10, 39,25; ¹⁹ F NMR (376 MHz, CDCb) δ -115,01; EIMS m/z 266.

E ample 53; Preparation of l,3~dichforo~S~(trans-2,2~dichforo~3~(dsetho y~ methyl )cycSopropy!)benzene (C83)

A I L 4~neck flask equipped with a mechanical stirrer, condenser, temperature probe and nitrogen Inlet was charged with (E)-l,3-dichloro-5-(3,3-diethoxyprop-l-en-l- yi)benzene (CS7) (40 g, 138 mmol) and CHCIs (447 rnL), Tetrabutyiammonium hexafluorophosphate(V) (1.081 g, 2,76 mmol) was added. The light yellow solution was heated to 45 °C. With vigorous stirring (~400 rpm), aqueous sodium hydroxide (50%, 182 mL) was added dropwise via addition funnel (over 1 hour). After 20 hours, the mixture was allowed to cool , The mixture was diluted with hexane (200 mL). The organic top layer was decanted (off the aqueous lower suspension) through Ce!lte ^® , washing the filtercake with hexane (200 mL). The filtrate was washed with brine (~200 mL), dried over sodium sulfate, filtered and concentrated to provide the title compound as a brown oil (50,2 g, 97%, purity 95%) : ^V NMR (300 MHz, CDCI ₃ ) δ 7.31 (t, J = 1.9 Hz, 1H), 7.15 (dd, J = 1.9, 0,7 Hz, 2H), 4.59 (d, J = 6.2 Hz, 1H), 3.80 - 3,57 (m, 4H), 2,77 (d, J = 8,5 Hz, 1H), 2,25 (dd, J = 8.5, 6,2 Hz, 1H), 1 ,30 (t, J = 7,0 Hz, 3H), 1,20 (t, J = 7.1 Hz, 3H),

The following compounds were prepared in like manner to the procedure outlined in Example S3 ;

l _? 2-Dich!oro~4~(trans~2 _f 2~dichforo~3-(diethoxyrnethyf )cyc!opropy!)benzene (C84)

Isolated as a brown oil ( 184 g, 99%) : *H NMR (400 MHz, CDCb) δ 7,43 (d, J = 8.2 Hz, 1H), 7.36 (dd, J = 2,2, 0.7 Hz, 1H), 7.10 (ddd, J = 8,3, 2.1, 0,7 Hz, 1H), 4.59 (d, J = 6,2 Hz, 1H), 3,82 - 3.55 (m, 4H), 2.77 (d, J = 8.5 Hz, 1H), 2.24 (dd, J = 8,5, 6.3 Hz, 1H), 1,30 (t, J = 7.0 Hz, 3H), 1.20 (t, J = 7.1 Hz, 3H).

1,2, 3~Trich!oro~S~f trans- 2, 2~dichforo~3-(diethoxyrn ethyl )c¾fc!opropy!)benzene S

Isolated as a brown oil (146 g, 93%) : ^l NMR (400 MHz, CDCb) δ 7,29 (d, J = 0.7 Hz, 2H), 4.59 (d, J = 6, 1 Hz, 1H), 3,82 - 3, 54 (m, 4H), 2,75 (d, J = 8.5 Hz, 1H), 2.23 (dd, 3 - 8.5, 6.1 Hz, 1H), 1.30 (t, J ^~ 7,0 Hz, 3H), 1,20 (t, 3 - 7,0 Hz, 3H). 2-ChSoro-4~(trans~2 _f 2~dichSoro-3-{di8thoxvm8thyS}cycfopropyl)~ l~f uoro~ benzene (C86)

Isolated as a brown oil (63 g, 96%) : ^l H NMR (400 MHz. CDC ) δ 7.44 (dd, J - 7.0 _f 2.2 Hz, 1H), 7.29 - 7.22 (m, 1 H), 7.09 (t, J - 8.7 Hz, 1 H), 6.62 (dd, J - 16.1, 1.2 Hz, 1 H), 6, 14 (dd, J = 16.1, 5.0 Hz, 1H), 5.05 (dd, J = 4.9, 1 ,2 Hz, 1H), 3,70 (dq, J = 9.3, 7.0 Hz, 2H), 3.56 (dq, J = 9.4, 7, 1 Hz, 2H), 1.25 (t, J = 7.1 Hz, 6H) ; ¹³ C NMR ( 101 MHz, CDCI ₃ ) δ 158.91, 156.42, 133.65, 133,62, 130,47, 128 ,65, 128.07, 128.05, 126,39, 126.32, 121.26, 121 ,08, 116,72, 116.51, 100.93, 61 , 17, 15.24; ¹⁹ F NMR (376 MHz, CDCb) δ - 116.36.

In another preparation, isolated as an amber oi l (22.38 g, 88%) : *H NMR (400 MHz, CDCb) δ 7.31 (m, 1H), 7.13 (m, 2H), 4.59 (d, J - 6.3 Hz, 1H), 3.69 (m, 4H), 2.78 (d, J = 8.5 Hz, 1H), 2.23 (dd, J = 8.5, 6.3 Hz, 1H), 1.30 (t, J = 7.1 Hz, 3H), 1.20 (t, J = 7. 1 Hz, 3H) ; ⁱ⁹ F NMR (376 MHz, CDCb) δ - 116.48; ; EIMS m/z 295 [M-OEt] .

Example 54; Preparation of {E)-l _f 3-dichi 3ro-5-(3,3-^isthoKyprop-l-er!-I- yH)ben;zen (CS7)

Step la : Acetaidehyde ( 120 g, 2688 mmol) was added to a stirred mixture of 3,5-dichlorobenzaldehyde (96 g, 538 mmol) in toluene (400 mL) at 0 °C. A solution of potassium hydroxide (3,35 g, 53,8 mmol) in methyl alcohol ( 10 mL) was added dropwise via addition funnel . The resulting mixture was sti rred at 0 °C for 4 hours until all of the 3,5-dichlorobenzaldehyde was consumed by thin layer chromatography. Step lb : Ethyl acetate (500 mL) and concentrated hydrochloric acid (37% aqueous, 44.1 mL, 538 mmol) were added to the reaction mixture. The resulting mixture was heated at 80 °C, and a colorless liquid was allowed to distill (200 mL) . The reaction mixture was diluted with water (500 mL) and extracted with ethyl acetate. The organic layer was washed with bri ne, dried over sodium sulfate, filtered, and concentrated to afford (£)-3~(3,5- dich!orophenyl) acrylaldehyde as a light yellow solid ( 115 g) which was used di rectly without further purification : ^X H NMR (300 MHz, CDCb) δ 9, 72 (dd, J = 7.4, 0, 5 Hz, 1H), 7.43 (q, J - 1.8 Hz, 3H), 7.35 (d, J = 16.0 Hz, 1H), 6.69 (del, J - 16.0, 7.4 Hz, 1H) . Step 2 : Triethoxymethane (31.4 g, 208 mmoi) and pyridin-l~ium 4- methylbenzenesulfonate (0.528 g, 2.079 mmo!) were added to a stirred solution of (£)- 3~(3,5-dichlorophenyl) acrylaidehyde (44 g, 208 mmoi) in ethanol (416 mL), The resulting mixture was stirred at 20 °C for 20 hours, A solution of saturated aqueous sodium carbonate (50 mL) was added to the reaction mixture. The resulting mixture was concentrated at 45 °C to remove the ethanol. The concentrate was diluted with water and extracted with hexane. The organic layer was washed with brine, dried over sodium sulfate, filtered and concentrated to afford the title product as a light yellow oil (56.13 g, 93%) : ^j H IMMR (400 MHz, CDCb) δ 7.25 (dt, J = 10.6, 1,9 Hz, 3H), 6,61 (dd, J = 16.1, 1.1 Hz, 1H), 6.22 (dd, J = 16.1, 4.7 Hz, 1H), 5.17 (s, 1H), 5.14 - 5,00 (m, 1H), 3,78 - 3.49 (m, 4H), 1.24 (q, J = 7.2 Hz, 6H); ¹³ C IMMR (101 MHz, CDC ) δ 139.34, 135.14, 130.27, 129.88, 127.71, 125.08, 100,60, 61,20, 15.25.

The following compounds were prepared In like manner to the procedure outlined In Example 54;

(£)-I _i .2-Dich!oro-4-(3 _i .3-diethoxvprop-I-en-I-vS}ben¾ene(CSe)

Isolated as an orange oil (142 g, 91%) : H NMR (300 MHz, CDCb) δ 7.48 (d, J = 2.0 Hz, 1H), 7.39 (dd, J = 8.3, 0.8 Hz, 1H), 6.62 (d, J = 16.1 Hz, 1H), 6,20 (ddd, J = 16, 1, 4.9, 0,8 Hz, 1H), 5,06 (dt, J = 4.9, 1.0 Hz, 1H), 3.78 - 3.48 (m, 4H), 1,25 (td, J = 7.1, 0,8 Hz, 6H),

(^-I _f l _f S-TnchSoro-S-CS _f S-dietho y ro -l-en-l-y^benxeneCCSg}

Isolated as an orange oil (40 g, 91%) : ^V H NMR (400 MHz, CDCb) δ 7.41 (s, 2H), 6, 58 (dd, J = 16.1, 1,2 Hz, 1H), 6,21 (dd, J = 16.1, 4,6 Hz, 1H), 5,06 (dd, J = 4.7, 1,2 Hz, 1H), 3,69 (dq, J = 9.3, 7, 1 Hz, 2H), 3,55 (dq, J = 9.5, 7,0 Hz, 2H), 1,25 (t, J = 7, 1 Hz, 6H).

(£)-2-Chloro-4-{3 _f 3-dsethox¾fprop-I-en-i-¾f -^-f^orobenz:ene (C90)

Isolated as an orange oil (283 g, 84%): *H NMR (400 MHz, CDCb) δ 7.44 (dd, J = 7.0, 2.2 Hz, 1H), 7.29 - 7,22 (m, 1H), 7,09 (t, J = 8,7 Hz, 1H), 6,62 (dd, J = 16.1, 1,2 Hz, 1H), 6,14 (dd, J = 16.1, 5,0 Hz, 1H), 5,05 (dd, J - 4.9, 1,2 Hz, 1H), 3,70 (dq, J = 9.3, 7.0 Hz, 2H), 3.56 (dq, J - 9.4, 7.1 Hz, 2H), 1.25 (t, J = 7.1 Hz, 6H); ¹³ C NMR (101 MHz, CDC ) δ 158.91, 156.42, 133.65, 133.62, 130,47, 128,65, 128.07, 128.05, 126,39, 126,32, 121.26, 121.08, 116.72, 116.51, 100.93, 61,17, 15.24; ¹⁹ F NMR (376 MHz, CDCi ₃ ) δ -116.36.

In another preparation, isolated as a colorless oil (16.75 g, 64%): *H NMR (400 MHz, CDCb) δ 7,43 (dd, J = 7,0, 2.2 Hz, 1H), 7.25 (m, 1H), 7,07 (t, J = 8,7 Hz, 1H), 6.62 (d, J = 16.1 Hz, 1H), 6.13 (dd, J = 16.1, 4.9 Hz, 1H), 5.05 (dd, J = 4,9, 1.0 Hz, 1H), 3.70 (dq, J - 9.4, 7.1 Hz, 2H), 3.56 (dq, J - 9.4, 7.0 Hz, 2H), 1.25 (t, J - 7,1 Hz, 6H); ¹³ C NMR (101 MHz, CDCb) δ 158.91, 156.42, 133.65, 133,62, 130,47, 128.65, 128.07, 128.05, 126.39, 126.32, 121,26, 121,08, 116.72, 116.51, 100.93, 61.17, 15.24; ¹⁹ F NMR (376 MHz, CDCb) δ -116.36; EIMS m/z 258.

Example 55: Preparation of (l/?,3 ?)-2,2-dichloro-3-(3,5- dich!oropheny cyciopropan -i-carboxy c acid (C91)

1 ^st resolution: (/¾)-l-Phenylethanamine (6.49 g, 53.0 mmo!) was slowly added to a stirred solution of rac-2,2-dichloro-3-(3,5-dichlorophenyl)cydopropane-carboxyli c acid) (32,45 g, 106 mmoi) in acetone (106 mL). The resulting solution was stirred at 45 °C. After a solid began to deposit, the mixture was placed at 5 °C for 4 hours, The solid was collected, washed with minimal cold acetone and dried. The white solid salt was diluted with ethyl acetate (100 mL) and washed with aqueous hydrochloric acid (1 N, 10 mL) and brine (30 mL). The organic Iayer was dried over sodium sulfate, filtered and concentrated to afford the title product as a white solid (10.33 g, 88% enantiomeric excess "ee").

2 ^nd resolution: (/?)-l-Phenylethanamine (3,4 g, 28 mmoi) was slowly added to a stirred soiution of rac-2 _f 2-dlchioro-3-(3,5~dichiorophenyl)cyciopropane-carboxyl ic acid) (10.33 g, 88% ee) in acetone (100 mL). After 2 hours, a solid was collected, washed with mi nima! coid acetone and dried, The solid was treated with aqueous hydrochloric acid to afford the title compound as a white solid (7.84 g, 97% ee, 24,2%) : Specific Rotation : +47.4 ( 10 mg/ ^' mL In acetonitrile, 589 nm, 25,2 °C) ; H NMR (300 MHz, CDC ) δ 7.36 (t, J = 1.9 Hz, 1H), 7.17 (dd, J = 1.9, 0.7 Hz, 2H), 3.48 - 3.37 (m, 1H), 2.87 (d, J = 8.3 Hz, 1 H) ; ¹³ C N MR (400 MHz, DMSO-cfc) δ 166.28, 136.40, 133.39, 127.27, 127.04, 61 ,36, 37.10, 35.98; ESIMS m/z 298,9 ([M-H] ^" ) ,

Enantiomeric excess values (ee%) was determined by Chiral HPLC method as follows: Column ; CHIRALPAK ^® ZWIX(+), particle size 3 urn, dimension 3 mm x 150 mm, DAIC 511584; Mobile phase which is a mixture of 500 mL acetonitrile, 500 mL methanol, 20 mL water, 1.9 mL formic acid, and 2.6 mL diethyiam!ne; Flow rate: 0.5 mL/mi n; Ti me: 9 min; Temperature: 25 °C .

The following compounds were prepared in like manner to the procedure outlined in Exampie 55:

( l^ _f 3^}-2,2~Dichloro~3~{3,4-dichforophenv!)cycfopropane~l~ carboxvlic acid (C92)

Isolated as a white solid (6,7 g, 30%, 96% ee) . Analytical data are consistent with racemlc acid C38.

( l^ _f 3^}-2,2~D!chloro~3~{3-ch!oro~4~fluoroph8nvf }cycSopropane~l~carboxy ic add (C93)

Isoiated as a white solid (0, 5 g, 13%, 99% ee) . Analytical data are consistent with racemlc acid C40.

( l^ _f 3^}-2,2~Dichloro~3~{3,4 _f 5~tnchforophenyS }cycfopropane- l~carbo3 y c acid

(C 19 '4)

Isolated as a white solid (2 g, 29%, 99% ee) . Analytical data are consistent with racemic acid C37,

( l^ _f 3^}-2,2-Dich!oro-3-{4-fSuoro-3-Ctrif!u 3romethy )phenv!}cyc!opropane-l- carboxylsc acid (C95)

Isolated as a clear colorless oil (0, 11 g, 14%, 80% ee) . Analytical data are consistent with racemic acid C76.

Example 56: Preparation of 3,4, -trichiorobenzafdehyde (C96)

In an oven dried, nitrogen flushed, 500 mL round-bottomed flask equipped with a pressure equalizi ng addition funnel, 5-bromo- l,2,3-trichlorobenzene ( 10.0 g, 38.4 mmo!) was dissolved in tetrahydrofuran ( 100 mL), and the resulting solution was cooled in an ice bath under nitrogen. /soPropyl magnesium chloride (2 M soiution

tetrahydrofuran, 21.1 mL, 42.3 mmo!) was added dropwise with good sti rring over 15 minutes via the addition funnel . After 0.5 hours, /V,/V-dimethylformamide (3.72 mL, 48.0 mmo!) was added to the dark sol ution with sti rring. After an additional 0.5 hours, hydrochloric acid ( 1 N, 100 mL) was added with stirring , The layers were separated, and the organic layer was washed with bri ne. The combined aqueous layers were extracted with ether, and the combined organics were dried over sodium sulfate, filtered, and concentrated to afford the title compound as a white solid ( 10 : 1 mixture of title compound to 1,2,3-trichlorobenzene, 7 ,96 g, 99%) : ^l NMR (CDCIs) δ 9,91 (s, 1H), 7.88 (s, 2H); EIMS m/z 209 ([M] ⁺ ) .

Example 57; Preparation of S-amino-2-c¾ ^r ano-Af-{ 2,4-difluorophen¾fl)-/¥- methy!benzamsde (C97)

To a solution of 2-cyano-/V-(2,4-difluorophenyl)-/V-methyl-5-nitrobenzamide (C138) (0.051 g, 0, 16 mmol) in methanol ( 1.5 mL) and water (0.5 mL) was added iron powder (0.045 g, 0.80 mmo!) and ammonium chloride (0.026 g, 0,48 mmol). The reaction mixture was heated at 60 °C for 2 hours. The reaction mixture was filtered through Ceiite ^® , and the filtrate was diiuted with ethyi acetate and washed with water. The combined organic phases were dried over magnesium sulfate, filtered, and concentrated to provide the title compound as a colorless oil (0.054 g, 99%) : Major isomer - ^V NMR (500 MHz, CDC ) δ 7.37 (td, J = 8,8, 5.8 Hz, 1H), 7.22 (d, J = 8.5 Hz, 1H), 6.82 - 6.70 (m, 2H), 6.53 (t, J - 1.9 Hz, 1H), 6.47 (eld, J - 8.5, 2.4 Hz, 1H), 4.27 (s, 2H), 3,41 (s, 3H); ^{) 9} F NMR (471 MHz, CDCb) δ -107,99 (p, J = 7.8 Hz), -115.44 (q, J = 8,8 Hz); ESIMS m/z 288 ([M÷H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 57:

Preparation of S-amsno-2-ch oro-/¥-{4-fSuorophen¾f|)benEamide (€98)

Isolated as a white solid (1.75 g, 54%).

S-Ar!i!no-2-ch!oro-i¥-(2,4-d!f uorophenyt)benxamsde (C99)

Isolated as a purple solid (0.37 g, 28%) ; H N R (400 MHz, CDCI ₃ ) δ 8.42 (tdd, J = 9,7, 6.0, 3.6 Hz, 1H), 8.25 (s, 1H), 7.21 (d, J = 8.5 Hz, 1H), 7.13 (d, J = 2.9 Hz, 1H), 6.97 - 6,88 (m, 2H), 6.73 (dd, J = 8.5, 2.9 Hz, 1H), 3.84 (s, 2H); ¹⁹ F NMR (376 MHz, CDC ) δ

-114.57 (d, J = 4.6 Hz), -125.78 (d, J = 4,6 Hz) ; ESIMS m/z 283 ([M+ H] ⁺ ).

M-AI!yS-5-amino-2-ch!oro- -{2-cvano-4-fSuorophen¾f|)benEa!Tiide (CIOO)

A mixture of amide rotamers was Isolated as a gold oil (0.156 g, quant.) : Major isomer - Ή NMR (500 MHz, CDCb) δ 7.53 - 7,34 (m, 2H), 7,27 - 7.11 (m, 2H), 6.90 (cl, J = 8.6 Hz, 1H), 6.44 (dd, J = 8.6, 2.8 Hz, 1H), 5.97 (ddq, J = 16.9, 10.1, 6.8 Hz, 1H), 5.29 - 5.04 (m, 1H), 4.94 (dq, J = 16,6, 1.2 Hz, 1H), 4.37 - 4.16 (m, 2H), 3.88 (s, 2H); ¹⁹ F NMR (471 MHz, CDCb) δ -110.82 (q, J = 7,5 Hz); ESIMS m/z 330 ([M + H] ⁺ ).

5-Amino-2-chSoro-W-(2-cyano-4-f!ujrophen¥S)-/¥-(prop-2- yn-l-y!)benzam!de (ClOl)

A mixture of amide rotamers was isolated as a colorless oil (0.067 g, 62%): *H NMR (500 MHz, CDCb) δ 7,70 - 7.40 (m, 2H), 7.26 - 7.15 (m, 1H), 7,01 - 6,64 (m, 2H), 6.46 (dd, J - 8.6, 2.8 Hz, 1H), 5.20 - 4.29 (m, 3H), 3.81 (d, J - 80,7 Hz, 1H), 2.29 (dt, J = 11.8, 2.4 Hz, 1H); ¹⁹ F NMR (471 MHz, CDCb) δ -110.08 (q, J - 7.2 Hz); ESIMS m/z 328 ([M÷H] ⁺ ).

(5~Amino-2~chforo~ -{2~cvano-4~fSuorophenyS)b8n :am!do)methv! acetate (C102)

A mixture of amide rotamers was Isolated as a colorless oil (0,063 g, 97%): H NMR (500 MHz, CDCb) δ 7.58 - 7.34 (m, 2H), 7,31 - 7.14 (m, 2H), 6.94 - 6.62 (m, 2H), 6.49 - 6,37 (m, 1H), 4,98 - 4.45 (m, 1H), 4.24 (s, 1H), 3,80 (d, J = 77.8 Hz, 2H), 1.26 (tcl, J - 7,2, 1.9 Hz, 3H); ¹⁹ F NMR (471 MHz, CDCb) δ -109.28 - -109.86 (m); ESIMS m/z 383 ([M + H] ).

2-ChSoro-i¥~(2-cyano~4~ffuorophenyS)~/¥~ethyf-5-nitrobenz: am!de (C103)

A mixture of amide rotamers was Isolated as a white solid (0,110 g, 64%): *H NMR (500 MHz, CDCb) δ 7,58 - 7.34 (m, 2H), 7.31 - 7.14 (m, 2H), 6.94 - 6,62 (m, 2H), 6.49 - 6.37 (m, 1H), 4.98 - 4,45 (m, 1H), 4,24 (s, 1H), 3.80 (m, 2H), 1.26 (td, J = 7.2, 1.9 Hz, 3H); ⁱ⁹ F NMR (471 MHz, CDCi ₃ ) δ -108.27 (s), -109.81 (q, J = 6.7 Hz); ESIMS m/z 348 ([M+H] ⁺ ).

5-Amino-/'-ben2:y!-2-chSoro-/¥-{2-cyan3-4-f!uoropheny!)benz amide (CI04)

A mixture of amide rotamers was isolated as a white foam (0,206 g, 98%): *H

NMR (500 MHz, CDCis) δ 7.38 - 7.17 (m, 7H), 7,15 - 6.92 (m, 2H), 6,92 - 6.84 (m, 1H), 6.68 (dd, J = 8.8, 2.8 Hz, 1H), 6.41 (dd, J = 8.6, 2,8 Hz, 1H), 5,76 (d, J = 14,5 Hz, 1H), 4.69 - 4,41 (m, 1H), 3.85 (m, 2H); ¹⁹ F NMR (471 MHz, CDC!;,) δ -108,73 - -110.02 (m); ESIMS m/z 380 ([M + H] ⁺ ).

ferf-Butyf /¥~[3~[(5~amino~2-ch!oro~ben¾oyf)~methyf-amsno]-2,6~dsfluo ro- phenyS]-i¥-ferf-butoxycarbonyhcarbamate (C105)

A mixture of amide rotamers was isolated as a colorless oil (0.140 g, 63%): *H NMR (500 MHz, CDCIs) δ 7,23 - 7.09 (m, 1H), 7.04 - 6.86 (m, 1H), 6,79 - 6,64 (m, 1H), 6.50 - 6,34 (m, 2H), 3,77 (s, 2H), 3,39 (s, 3H), 1,43 (d, J = 13,3 Hz, 18H); ¹⁹ F NMR (471 MHz, CDCi;,) δ -116,85 - -118.50 (m), -123.55 (s); ESIMS m/z 534

([M + Na] ⁺ ).

ferf-Butyf /¥~[3~[(5~amino~2-ch!oro~benTOyf)~methyf-amsno]-2,6~dsfluor o- phenyS]~i¥-methyf~carbamate (C106)

A mixture of amide rotamers was isolated as a pale yellow foam (0,114 g, 92%): ⁵ H NMR (500 MHz, CDC ) δ 7,25 - 6.86 (m, 2H), 6.85 - 6.28 (m, 3H), 4.50 (dd, J - 72,3, 40.3 Hz, 1H), 3.41 (s, 3H), 3.23 - 2,99 (m, 3H), 1.56 (s, 1H), 1.55 - 1.30 (m, 9H); ⁱ⁹ F N R (471 MHz, CDCi ₃ ) δ -118.27 (dt, J = 10,7, 5.6 Hz), -122.00 - -124.47 (m); ESIMS m/z 448 ([M + Na] ⁺ ).

5-Amino-2-chSoro-W,W-dsmethy /"-pheny!benzohvdrazide (C107)

Isolated as a ye!!ow solid (0.203 g, 80%): *H NMR (400 MHz, DMSO-ds) δ 7.32 - 7.22 (m, 2H), 6.99 (d, J ^~ 8.4 Hz, 1H), 6.87 (t, J - 7.1 Hz, 1H), 6.83 - 6.75 (m, 2H), 6.48 (q, J = 2.6 Hz, 2H), 5.24 (s, 2H), 3.04 (s, 3H), 2.98 (s, 3H); ES!MS m/z 273 ([Μ + ΗΓ),

ferf-Buty-i¥-[3-[(5-amino-2-chSoro-3-fiuorobenzoyi}amino ]-2 _f 6- dif uoropheny!]-W-fert-butoxycarbony carbamate (CI08)

Isolated as a !ight-tan solid (0.864 g, 71%): mp 150 - 153 °C; *H NMR (400 MHz, DMSO-tfc) δ 10.39 (s, 1H), 7.68 (td, J = 8.8, 5.8 Hz, 1H), 7.25 (td, J = 9.2, 1.7 1H), 6.59 (ddd, J = 7.0, 5.5, 2.5 Hz, 2H), 5.82 (s, 2H), 1.40 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -115,54, -123.59, -126.30; HRMS-ESI (m/z) [M ⁺ ] ⁺ caicd for

OJH¼CIF-.; JQ.; _; 515.1435; found, 515.1431.

3-Am!no-2 _f 6-d!chSoro-W-( -pentafluoropropvS}ben¾am!de {009}

Isolated as a tan solid (0.057 g, 82%): mp 116 - 128 °C; *H NMR (400 MHz, CDC ) δ 7.10 (d, J = 8.7 Hz, 1H), 6.74 (d, J = 8.7 Hz, 1H), 6.04 (s, 1H), 4.18 (td, J = 15,1, 6.5 Hz, 3H); ¹⁹ F NMR (376 MHz, CDC ) δ -84.15, -121.50; EIMS m/z 336.

3-Am!no-W-ethy!-2 _? 6-difluorobenzamsde (CI 10)

Isolated as a cream-co!ored solid (0.036 g, 44%): mp 123 - 126 °C; *H N R (400 MHz, DMSQ-ds) δ 8,56 (t, J = 5.6 Hz, 1H), 6.92 - 6,69 (m, 2H), 5,09 (s, 2H), 3.23 (qd, J = 7.2, 5.5 Hz, 2H), 1.08 (t, J = 7,2 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ - 131,96,

-131.96, -135.48, -135.49; ESIMS m/z 201 ([M + H] ⁺ ).

3-Amino-2 _f 6-difiuoro-W-(2 _f -tr!f!uiroethv }ben2:a!T!!de (CI II)

Isolated as a yellow solid (0.106 g, 68%): mp 133 - 136 °C; ^j H NMR (400 MHz, DMSO- s) δ 9,30 (t, J = 6,3 Hz, 1H), 6,93 - 6.74 (m, 2H), 5.17 (s, 2H), 4.07 (qd, J = 9.7, 6.3 Hz, 2H); ⁱ⁹ F NMR (376 MHz, DMSO-ds) δ -70,67, -131,95, -131,95, -135,20, - 135,21; ESI S m/z 255 ([M + H] ⁺ ).

3-Am!no-2 _f 6-d!fiuoro-W-( -pentafSuoroprop¾f benza!Ti!de (CI 12)

Isolated as a light-brown solid (0,090 g, 59%): mp 82 - 85 °C; *H NMR (400 MHz, DMSO-ds) δ 9.31 (t, J = 6,3 Hz, 1H), 6,93 - 6.72 (m, 2H), 5.17 (s, 2H), 4,12 (td, J = 15,5, 6.4 Hz, 2H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -83.42, -120.11, -131.86, -135,12; ESIMS m/z 305 ([M+H] ⁺ ).

S-Amino-l _f e-dichSoro-i -ethyfben-i rnide (CI 13)

Isolated as a peach-colored solid (0.058 g, 68%): mp 179 - 182 °C; H NMR (400 MHz, DMSO-de) δ 8,45 (t, J = 5.7 Hz, 1H), 7.10 (d, J = 8.7 Hz, 1H), 6.77 (d, J = 8.8 Hz, 1H), 5.61 (s, 2H), 3.22 (qd, J = 7,2, 5.6 Hz, 2H), 1.09 (t, J = 7.3 Hz, 3H);

ESIMS m/z 233 ([M+H] ⁺ ).

3-Am!no-2 _f 6-d!chSoro-W-(2 _f -tnfSuoroethvl)ben2:am!de (C114)

Isolated as an orange solid (0,125 g, 77%): mp 178 - 181 °C; ^l NMR (400 MHz, DMSO-ds) δ 9,23 (t, J = 6,4 Hz, 1H), 7,13 (d, J = 8.8 Hz, 1H), 6.81 (d, J = 8.8 Hz, 1H), 5.68 (s, 2H), 4.05 (qd, J = 9.7, 6.3 Hz, 2H); ⁱ⁹ F NMR (376 MHz, DMSO-cfc) δ -70,05; ESIMS m/z 287 ([M+H] ⁺ ),

3-Amino-2 _f 6-d!fiuoro-W-propv!ben¾am!de (CI IS)

Isolated as a !ight-orange oil (0.080 g, 62%): *H NMR (400 MHz, DMSOc/s) δ 8.54 (t, J = 5,7 Hz, 1H), 6,90 - 6.65 (m, 2H), 5.09 (s, 2H), 3.17 (td, J = 6.8, 5,7 Hz, 2H), 1.48 (h, J = 7.2 Hz, 2H), 0.89 (t, J = 7,4 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ

-131.93, -135.41, -135.41; ESIMS m/z 215 ([M + H] ⁺ ).

3-Amino-2 _f 6-d!chSoro-W-propv!benz:amsde (CI 16}

Isolated as a tan solid (0.089 g, 72%): mp 165 - 168 °C; *H NMR (400 MHz, DMSO-ds) δ 8,47 (t, J = 5,7 Hz, 1H), 7,10 (d, J = 8.8 Hz, 1H), 6.77 (d, J = 8.7 Hz, 1H), 3.16 (td, J = 6,8, 5.6 Hz, 2H), 1.50 (h, J = 7,2 Hz, 2H), 0,91 (t, J = 7.4 Hz, 3H); ESIMS m/z 247 ([M + H] ⁺ ).

3~Amino~2 _f 6~diffuoro~M~(3 _f 3 _f 3~trifluoropropy!)benzamide (CI 17)

Isolated as an orange solid (0,104 g, 67%): mp 71 - 74 °C; *H NMR (400 MHz, DMSO-ds) δ 8,81 (t, J = 5,7 Hz, 1H), 6,92 - 6.69 (m, 2H), 5.13 (s, 2H), 3.45 (q, J = 6.5 Hz, 2H), 2,57 - 2.43 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-efc) δ -63,90, -131.90, -135.35; ESIMS m/z 269 ([M+H] ⁺ ).

3-Am!no-2 _f 6-d!chSoro-W-(3 _f 3 _f 3-tnfSuoroprop¾f benza!Ti!de (CI 18)

Isolated as a peach-colored solid (0.129 g, 80%); mp 144 - 147 °C; *H NMR (400 MHz, DMSO-ds) δ 8,77 (t, J = 5.7 Hz, 1H), 7.11 (d, J = 8.7 Hz, 1H), 6.79 (d, J = 8.8 Hz, 1H), 5.65 (s, 2H), 3.43 (td, J = 6.9, 5.7 Hz, 2H), 2.58 - 2,44 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-cs) δ -64.00; ESIMS m/z 301 ([M + H] ⁺ ).

lore?-

Isolated as a peach-colored solid (0.092 g, 74%); mp 170 - 172 °C; H NMR (400 MHz, DMSQ-c/s) δ 8,78 (t, J = 5.6 Hz, 1H), 7.11 (d, J = 8.7 Hz, 1H), 6.78 (d, J = 8.8 Hz, 1H), 5.63 (s, 2H), 4.50 (dt, J = 47,4, 5.1 Hz, 2H), 3.51 (dq, J = 26,6, 5.3 Hz, 2H); ⁱ⁹ F NMR (376 MHz, DMSO-c/e) δ 16.09; ESIMS m/z 251 ([M + H] ⁴ ),

3-Am!no-2 _f 6-d!chSoro-W-( -chloropropv!)benzam!de (CI 20)

Isolated as a peach solid (0.128 g, 84%); mp 124 - 127 °C; Ή NMR (400 MHz, DMSO-c/s) δ 8,59 (t, J = 5,7 Hz, 1H), 7,11 (d, J = 8.7 Hz, 1H), 6.78 (d, J = 8.8 Hz, 1H), 5.64 (s, 2H), 3.71 (t, J = 6.6 Hz, 2H), 3.33 (d, J = 5,8 Hz, 5H), 1,95 (p, J = 6.7 Hz, 2H); ESIMS /z 281 (TM+H] ⁺ ),

3-Am!no-2 _f 6-difiuoro-W-(2-fluoroethyS)ben¾amide (CI 1}

Isolated as a purple solid (0.079 g, 74%); mp 97 - 99 °C; ¹ H NMR (400 MHz, DMSO-cs) δ 8,83 (t, J = 5,6 Hz, 1H), 6,89 - 6.71 (m, 2H), 5.11 (s, 2H), 4.49 (dt, J = 47,5, 5.0 Hz, 2H), 3.52 (dq, J = 27,0, 5.2 Hz, 2H); ¹⁹ F NMR (376 MHz, DMSO-c/s) δ 15,42, -131.81,

-131.82, -135.24, -135.25; ESIMS /z 219 ([M + H] ⁺ ).

3-Am!no-W-(3-ch oroprop - -difluoroben2:amsde (C122)

Isolated as an amber oi! (0,083 g, 73%): *H NMR (400 MHz, DMSO-de) δ 8.67 (t, J = 5.7 Hz, IH), 6.93 - 6.66 (m, 2H), 5,12 (s, 2H), 3.68 (t, J = 6.6 Hz, 2H), 3.34 (q, J = 6.4 Hz, 2H), 1.93 (p, J = 6,6 Hz, 2H); ¹⁹ F NMR (376 MHz, DMSG-de) δ -132,00, -132,00, -135.48, -135.48; ESIMS m/z 249 ([M + H] ⁺ ).

3-Am!no-W-(2 _f 4-d!fuorophenyS)-2 _? 6-difluoroben¾amsde (CI 23}

Isolated as a peach-colored solid (0.077 g, 46%); mp 147 - 150 °C; H NMR (400 MHz, DMSO-de) δ 10,51 (s, IH), 7.75 (td, J = 8,9, 6.1 Hz, IH), 7.37 (ddd, J = 11,4, 9.2, 2,8 Hz, IH), 7,12 (tt, J = 8,7, 1.9 Hz, IH), 6.95 - 6.77 (m, 2H), 5,20 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-G%) δ -113,26, -113,28, -117.37, -117.39, -131,64, -131,65, - 134,94, -134,95; ESIMS m/z 285 ([M÷H] ⁺ ),

3~Amino~2 _f 6~diffuoro~M~( -f!uorophen¾fl)benzamide (CI 24)

Isolated as a light-orange solid (0,114 g, 77%): mp 164 - 167 °C; ^l H NMR (400 MHz, DMSO- δ) δ 10.74 (s, IH), 7,82 - 7.62 (m, 2H), 7,20 (t, J = 8.9 Hz, 2H), 7.04 - 6.68 (m, 2H), 5.22 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-ds) δ -118.34, -118.36, -131.90, -131.90, -135.32, -135.33; ESIMS m/z 267 ([M + H]÷).

i¥-(4~Acetamidophen -3~amino~2 _f 6~difuorobenzamid8 (CI 25)

Isolated as a white solid (0.017 g, 54%): mp 210 - 213 °C; *H NMR (400 MHz, DMSO-cfc) δ 10.59 (s, IH), 9.92 (s, IH), 7.60 (d, J - 9.0 Hz, 2H), 7.54 (d, J - 9.0 Hz, 2H), 6.94 - 6.77 (m, 2H), 5.19 (s, 2H), 2,03 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-ds) δ - 131.84,

-131.85, -135,29, -135,30; ESIMS m/z 306 ([M + H] ⁺ ).

i¥-(4-Acetamsdophenv!)-3-amino-2 _f 6-dichSoroben¾amide (CI 26)

Isolated as a gray solid (0.029 g, 25%): mp 215 - 278 °C; H NMR (400 Hz, DMSO-cfc) δ 10,50 (s, IH), 9.91 (s, IH), 7.62 - 7,56 (m, 2H), 7,56 - 7.50 (m, 2H), 7.17 (d, J - 8.8 Hz, IH), 6.84 (d, J - 8.8 Hz, IH), 5.70 (s, 2H), 2.02 (s, 3H); ESIMS m/z 338 ([Μ + ΗΓ),

3-Amino~2 _f 6-dich!oro~/¥~( ~ffuorophenyS)benz:amsd8 (CI 27)

Isolated as a white solid (0.093 g, 81%): mp 204 - 207 °C; ^J H NMR (400 MHz, DMSO-cfc) δ 10,65 (s, IH), 7.75 - 7.66 (m, 2H), 7.24 - 7,14 (m, 3H), 6.85 (d, J - 8.8 Hz, IH), 5,73 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-ds) δ -118.56; ESIMS m/z 299

([Μ + ΗΓ),

3-AminG-2,6-d!cWGro-Af-pheny!benzamide (CI 28)

Isolated as a white solid (0,129 g, 91%): mp 172 - 175; ^J H NMR (400 MHz, DMSO-de) δ 10,58 (s, IH), 7.73 - 7.63 (m, 2H), 7.41 - 7,27 (m, 2H), 7,18 (d, J = 8,8 Hz, IH), 7,14 - 7,06 (m, IH), 6.85 (d, J = 8,8 Hz, IH), 5,72 (s, 2H), ESIMS m/z 281 ([Μ + ΗΓ),

3-Amino-2,6-dichtoro-/¥-( -dsfSuorophenvi)benzamide (CI 29)

Isolated as a white solid (0,127 g, 87%): mp 187 - 189 °C; ¹ H NMR (400 MHz, DMSO- s) δ 10,47 (s, IH), 7,76 (td, J = 8,9, 6.2 Hz, IH), 7.35 (ddd, J = 10,7, 9,1, 2,9 Hz, IH), 7,23 - 7.08 (m, 2H), 6.84 (d, J = 8,8 Hz, IH), 5,71 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -113.48, -113,50, -117,40, -117,41; ESIMS m/z 317 ([ + H] ⁺ ).

3-Am!no-W-(4-am!nophen¾f!)-2,6-dichloro-W-methv'lben¾am sde (CI30)

Isolated as a waxy gray solid (0.052 g, 80%): ^l NMR (400 MHz, DMSO- e) δ 7.03 - 6.89 (m, 3H), 6.58 (d, J = 8.7 Hz, 1H), 6.38 - 6.31 (m, 2H), 5.47 (s, 2H), 5.10 (s, 2H), 3.24 (s, 3H); ESIMS m/z 310 ([M + H] ⁺ ),

ferf~Butyf~M~[3~[(3~amino~2,6~dich!oroben-5:oyS}amino]-2 _i 8~dsf!uorophenyf]~M~ ferf-butoxycarbonyfcarbamate (C131)

Isolated as a waxy white solid (0.166 g, 61%): mp 84 - 89 °C; *H NMR (400 MHz, DMSO-cfc) δ 10.58 (s, 1H), 7,76 (td, J = 8.8, 5.8 Hz, 1H), 7.26 (td, J = 9.2, 1.7 Hz, 1H), 7.18 (d, J = 8,7 Hz, 1H), 6,85 (d, J = 8.8 Hz, 1H), 5.73 (s, 2H), 1.40 (s, 18H); ¹⁹ F NMR (376 MHz, DMSQ- s) δ -123,71, -126,64; ESIMS m/z 530 ([M-H] ^" ).

3-Am!no-2 _? 6-d!f!uoro- f-ph f!ben2:amide (C132)

Isolated as a tan solid (0.109 g, 85%); mp 173 - 176 °C; ^j H NMR (400 MHz, DMSO-de) δ 10.67 (s, 1H), 7,75 - 7.64 (m, 2H), 7.41 - 7.30 (m, 2H), 7.19 - 7,07 (m, 1H), 6.98 - 6,77 (m, 2H), 5.21 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-ds) δ -131.91, - 131,92, -135,34, -135.35; ESIMS m/z 249 ([M + H] ⁺ ).

ferf~Butyf~M~[3~[(3~amino~2,6~difluoroben-ioyl)amino]~2 _f 6~diffuc5rophenyS]~Af~ ferf-butoxycarbonyfcarbamate (C133)

Isolated as an orange solid (0,086 g, 61%) : mp 148 - 151 °C; ^l NMR (400 MHz, DMSO- s) δ 10,62 (s, 1H), 7,75 (td, J = 8,8, 5.8 Hz, 1H), 7.26 (td, J = 9.3, 1.7 Hz, 1H), 6.99 - 6.78 (m, 2H), 5.22 (s, 2H), 1,40 (s, 18H) ; ⁱ⁹ F NMR (376 MHz, DMSQ-de) δ - 123,58, -126,68, -131.69, -131.70, -134.99, - 135.00; ESIMS m/z 498 ([M-H] ),

Example 58: Preparation of fert-Buty {4-(5-amino-2-ch!orobenza!Ti!do)-3- methySphenvl)carbamate (C134)

To a solution of tert- butyl (4-(2-chloro-5-nitrobenzamido)-3- methy!phenyl)carbamate (C153) (2.2 g, 5,42 mmol) in ethyl acetate (54 mL) under Nz was added Pd/C (0.95 g, 0.445 mmol). The reaction mixture was placed under approx. one atmosphere of hydrogen (balloon) and stirred overnight at room temperature, The reaction mixture was filtered through a plug of Celite ^® and concentrated under reduced pressure to afford the title compound as a brown foam (2,09 g, 92%) : *H NMR (400 MHz, DMSO-Gfe) δ 9.68 (s, 1H), 9.28 (s, 1H), 7,35 (d, J = 2.2 Hz, 1H), 7.26 (dd, J = 8.6, 2.4 Hz, 1H), 7.18 (d, J = 8.6 Hz, 1H), 7.12 (d, J = 8,6 Hz, 1H), 6,75 (d, J = 2.7 Hz, 1H), 6.64 (dd, J - 8.6, 2.7 Hz, 1H), 5.64 (s, 2H), 2.21 (s, 3H), 1.48 (s, 9H); ¹³ C NMR (101 MHz, DMSO-de) δ 165.69, 152.77, 147.30, 137.32, 137,27, 133, 57, 130.14, 129.79, 126.41, 119.77, 115.93, 115.55, 113,84, 78,91, 54.86, 28.13, 18,21; ESIMS m/z 374 ([M-H] ^" ),

The following compounds were prepared In like manner to the procedure outlined in Example 58 :

fert-Buty W-({tert-butoxv}carbony -^-(3-{5-amino-2-ch!oroben2:arnido)-2 _? 6- difiuQrophenyl)carbamate (C135)

Isolated as a white solid (2,89 g, 59%) : Ή NMR (400 MHz, DMSO-ofe) δ 10,28 (s, 1H), 7.67 (td, J = 8.8, 5.8 Hz, 1H), 7,24 (td, J = 9.3, 1,7 Hz, 1H), 7, 13 (d, J = 8.6 Hz, 1H), 6.73 (d, J = 2.7 Hz, 1H), 6.65 (dd, J = 8,6, 2.8 Hz, 1H), 5.48 (s, 2H), 1.40 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-ds) δ -123,86, -126,24; ESIMS m/z 496 ([M-H] ^" ), 5-Amino~2~chSoro~N~(3~(2 _f 2-diffuoroacetamido)~2,4~dif!uorophenvl}benzani!de (C136)

Isolated as a brown foam (0,485 g, 97%): ESIMS m/z 376 (TM + H] + ), *H !MMR (400 MHz. DMSO-d ) δ 10,77 (s, 1H), 10,28 (s, 1H), 7.73 - 7.54 (m, 1H), 7.31 - 7,18 (m, 1H), 7,13 (d, J - 8.6 Hz, 1H), 6.73 (d, J = 2.8 Hz, 1H), 6.70 - 6.27 (m, 2H), 5.49 (s, 2H), ¹⁹ F NMR (376 MHz, DMSO-tfe) δ -120,94 (d, J = 2,6 Hz), -124.00 (d, J = 2.7 Hz), -125.80.

Example 59: Preparation of tert-butyl-V-((tert-butoxyl)carbonyl)-v-C5-C5- amino-2-ch!orobenza!T!ido)-2 _? 4-difluorophenyl)carbamate (C137)

To a vial containing tert-butyl-/V-((tert-butoxy)carbonyl)-/V-(5-amino-2,4- difluoropbenyl)carbamate (C183) (0,4 g, 1.16 mmol) were added 2-chloro-5- nitrobenzoic acid (0.23 g, 1.16 mmol), 4-dimethylaminopyridine (0.15 g, 1,28 mmol), 1- ethyl-3-(3-dimethylaminopropyl)carbodiimide (0,33 g, 1.74 mmo!), and dich!oromethane (6 mL), The reaction mixture was stirred at room temperature for 18 h then was directly loaded onto a prepacked Celite ^® cartridge and flushed through a silica gel column with ethyl acetate/hexanes. The resulting yellow foam was dissolved in ethyl acetate (2 mL) and 10% palladium on carbon (10 mg, 0,009 mmoi) was added. The slurry was stirred under an atmosphere of hydrogen gas (balloon) for 7 hours. The slurry was filtered through a pad of Celite ^® with ethyl acetate and concentrated, Purification by flash column chromatography gave the title compound as a white foam (0,1479 g, 25%): *H NMR (400 MHz, DMSQ- e) δ 10,27 (s, 1H), 7,67 (t, .7= 8.1 Hz, 1H), 7,50 (t, J = 10.1 Hz, 1H), 7.12 (d, J = 8,6 Hz, 1H), 6,73 (d, J = 2,7 Hz, 1H), 6,65 (dd, J = 8,6, 2.7 Hz, 1H), 5.48 (s, 2H), 1,40 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -117,30 (d, J = 6,4 Hz), - 122,18 (d, J = 6.4 Hz); ESIMS m/z 495.6 [(M-H] ),

To a solution of 2-bromo-A/-(2,4-difluorophenyl)-/V-methyl-5-nitrobenzamide (0.120 g, 0,323 mmol) (C149) in W,W-dimethylformamide ( 1.6 mL) was added copper(l) cyanide (0.145 g, 1.62 mmol) . The reaction mixture was degassed under vacuum, backfi lled with nitrogen, capped in a 2-mL microwave vial, and heated at 160 °C for 20 mi nutes in a Biotage Initiator ^® microwave reactor with external IR-sensor temperature monitori ng from the side of the vessel . The reaction mixture was diluted with ethyl acetate while sti rring vigorously and then filtered through Cellte ^® washing with ethyl acetate. The filtrate was washed with brine. The organic phase was dried over magnesium sulfate, filtered, and concentrated . Purification by flash column

chromatography using 0-25% ethyl acetate/hexanes as eluent provided the title compound as a mixture of amide rotamers as a beige solid (0,051 g, 47%) : *H N MR (500 MHz, CDCh) δ 8.20 (d, J = 8 , 1 Hz, 2H), 7,81 - 7.72 (m, 1H), 7.39 (td, J = 8.8, 5.7 Hz, 1 H), 6.86 (dddd, J = 8,9, 7 , 5, 2 ,8, 1.5 Hz, 1H), 6,76 (ddd, J = 10, 6, 8.3, 2.8 Hz, 1H), 3.50 (s, 3H) ; ¹⁹ F N MR (471 MHz, CDC ) δ - 106.15 (h, J = 8, 1 Hz), - 115. 12 (q, J = 8.9 Hz) ; ESIMS m/z 318 ([M + H] ⁺ ) .

Example 61 : Preparation of Af~a!lyS~2~chloro~M~(2~cyano~4~ff uorophenyS)~S~ nitrobenzarrside (C139)

To a solution of 2-chloro-/V-(2-cyano-4-fluorophenyl)-5-nitrobenzamide (CI52) (0.200 g, 0,626 mmol) in tetrahydrofuran (6.3 mL) cooled i n an ice bath was added sodium hydride (60% oil immersion, 0.030 g, 0,75 mmol). The sl urry was stirred for 30 minutes, and ailyl bromide (0.081 mL, 0.94 mmol) was added. The reaction mixture was sti rred for 18 hours. The reaction was quenched by the slow addition of water ( 10 mL) and diluted with ethyl acetate ( 10 mL) , The organic layer was dried over magnesium sulfate, filtered, and concentrated . Purification by flash col umn chromatography using 0- 25% ethyl acetate/hexa es as el uent provided the title compound as a mixture of amide rotamers as an off-white solid (0.162 g, 68%) ; Major isomer - Ή NMR (500 MHz, CDC ) δ 8.31 (d, J = 2.7 Hz, 1H), 8.05 (dd, J = 8.8, 2.7 Hz, 1H), 7.42 (d, J = 8.8 Hz, 1H), 7,40 (s, 1H), 7.30 (dd, J = 7,4, 2.9 Hz, 1H), 7.20 (ddd, J = 8,9, 7.5, 3,0 Hz, 1H), 5,99 (ddt, J = 17.0, 10.1, 6.7 Hz, 1H), 5.30 - 5.17 (m, 2H), 4.89 (dd, J = 14,6, 6.0 Hz, 1H), 4.29 (dd, J = 14.6, 7.5 Hz, 1H); ¹⁹ F NMR (471 MHz, CDCb) δ -108, 13 (q, J = 6,9 Hz); ESIMS m/z 360 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 61 :

2~Chloro~i¥~(2~cyano~4~ffuoropheny!)~5~nitro~M-{prop~2~vn~l ~vf }benzaniide CC140)

A mixture of amide rotamers was isolated as a white foam (0, 128 g, quant,) : Major isomer - *H NMR (500 MHz, CDCb) δ 8.30 (d, J = 2.6 Hz, 1H), 8.07 (dd, J = 8,8, 2.6 Hz, 1H), 7.54 (dt, J = 6,7, 3.4 Hz, 1H), 7,43 (d, J = 8,8 Hz, 1H), 7,33 (dd, J = 7.3, 2.9 Hz, 1H), 7.23 (ddd, J - 8.9, 7.5, 3.0 Hz, 1H), 5.21 (dd, J - 17.4, 2.5 Hz, 1H), 4.41 (m, 1H), 2.34 (t, J - 2.5 Hz, 1H); ¹⁹ F NMR (471 MHz, CDCb) δ -107.37 (q, J - 6.8 Hz); ESIMS m/z 358 ([M÷H] ⁺ ),

(2~Chforo~ ¥~{2~cyano~4~f!uorophenvl}-5-nitrobenz:amsdo}methyf acetate

(C141)

A mixture of amide rotamers was isolated as a yeiiow oii (0,067 g, 52%) : ^J H NMR (500 MHz, CDCb) δ 8,50 - 8.34 (m, 1H), 8.35 - 8.04 (m, 1H), 7.73 - 7,39 (m, 3H), 7.34 - 7.19 (m, 1H), 5.99 - 5.80 (m, 1H), 5.56 - 5.28 (m, 1H), 2.14 (d, J - 4.0 Hz, 3H); ¹⁹ F NMR (471 MHz, CDCb) δ -108.78 (q, J - 7.0 Hz); ESIMS m/z 392 ([M + H] ⁺ ). 2~Chloro~i¥~(2~cyano~4~ffuoropheny!)~/¥~ethvf~5~nitroben2a mide (C142)

A mixture of amide rotamers was Isolated as a white solid (0.110 g, 64%): Major isomer - Ή NMR (500 MHz, CDC ) δ 8.32 - 8.28 (m, 1H), 8.04 (dd, J - 8.8, 2.7 Hz, 1H), 7.40 (dd, J - 8.9, 5.2 Hz, 2H), 7.32 (dd, J - 7.4, 2.9 Hz, 1H), 7.22 (ddd, J - 8.9, 7.4, 2.9 Hz, 1H), 4.27 (dq, J = 14.2, 7.2 Hz, 1H), 3.84 (dq, J = 14.1, 7.1 Hz, 1H), 1.31 (t, J = 7,2 Hz, 3H); ¹⁹ F NMR (471 MHz, CDC ) δ -108.27 (s); ESIMS m/z 348 ([M + H] ⁺ ). W-Benzy-2-ch!oro-i¥-(2-cyano-4-fiuorophenyt)-5-nitrobenzami de (CI43)

A mixture of amide rotamers was Isolated as a white foam (0,216 g, 80%): ^X H

NMR (500 MHz, CDCb) δ 8.32 - 8.27 (m, 1H), 8,03 (dd, J = 8.8, 2,6 Hz, 1H), 7,40 (d, J = 8.8 Hz, 1H), 7.33 - 7.24 (m, 6H), 7.02 - 6.92 (m, 2H), 5.77 (m, 1H), 4.60 (m, 1H); ¹⁹ F NMR (471 MHz, CDCb) δ -107.79 - -108.26 (m); ESIMS m/z 410 ([M + H] ⁺ ).

ferf-Butyf /¥~fert~butoxycarbonyf~i¥-[3~[{2~chforo~S~nitro~benzovl)-m ethvf~ amino]~2,6~dsf!uoro~phenyS]carbamate (C144)

A mixture of amide rotamers was Isolated as a pale yellow oil (0.179 g, 55%): ^X H NMR (500 MHz, CDCb,) δ 8.15 (dd, J - 2,6, 1.5 Hz, 1H), 8.03 (dd, J - 8.8, 2.7 Hz, 1H), 7.36 (d, J = 8.8 Hz, 1H), 7.29 - 7,23 (m, 1H), 6.81 (td, J = 8,8, 1.9 Hz, 1H), 3.45 (s, 3H), 1.41 (dd, J = 39,8, 7.5 Hz, 18H); ¹⁹ F NMR (471 MHz, CDCb) δ -115.52 (s), -120.91 - -123,25 (m); ESIMS m/z 541 ([M + H] ⁺ ).

ferf-Buty /¥-[3-[ayyi-(2-chSoro-5-nitro-benTOy )amino]-2 _f 6-difSuoro-phenv!]-W- ferf-butoxycarbonyhcarbamate (€145)

A mixture of amide rotamers was Isolated as a colorless oil (0,068 g, 38%): *H NMR (500 MHz, CDCis) δ 8,16 (t, J = 2.2 Hz, 1H), 8,03 (dd, J = 8,8, 2.7 Hz, 1H), 7,36 (d, J - 8.8 Hz, 1H), 7,31 - 7,22 (m, 1H), 6,81 (td, J - 8,8, 1.8 Hz, 1H), 5.95 (ddt, J - 16,9, 10.2, 6,6 Hz, 1H), 5,26 - 5,16 (m, 2H), 4.61 (dd, J - 14.9, 6.3 Hz, 1H), 4.34 (dd, J = 14.7, 6.9 Hz, 1H), 1.46 - 1.32 (m, 18H); ¹⁹ F NMR (471 MHz, CDCia) δ -114,18 - - 116,23 (m), -121,37 (s); ESIMS m/z 590 ([M + Na] ).

ferf-Butyf /¥~fert~butoxycarbonyf~i¥-[3~[{2~chforo~S~nitro~benzovl)-p rop-2-ynyS- amino]-2,6- sf!iuGr -pheny!]carfoamate (C146)

A mixture of amide rotamers was Isolated as a beige sticky solid (0.144 g, 85%); ⁵ H NMR (500 MHz, CDCIs) δ 8,17 (t, J = 2,2 Hz, 1H), 8,04 (dd, J = 8.8, 2.7 Hz, 1H), 7.47 - 7,40 (m, 1H), 7.37 (d, J = 8.8 Hz, 1H), 6.84 (td, J = 8,8, 1.8 Hz, 1H), 4,99 (d, J = 17.4 Hz, 1H), 4.43 - 4.31 (m, 1H), 2,29 (t, J = 2.5 Hz, 1H), 1,40 (dd, J = 31,4, 3.8 Hz, 18H); ¹⁹ F NMR (471 MHz, CDC ) δ -114,79 (s), -121.53 (s); ESIMS m/z 588 ([M + Na] ⁺ ).

ferf-Buty! {3~{2~chloro~i¥-meth¾fl~S~nitrobenzamido}~2 _f 6~

diffuorophenyS)(methy!)carbarnate (C147)

A mixture of amide rotamers was Isolated as a colorless oil (0,071 g, 26%): ^L NMR (500 MHz, CDCb) δ 8,16 (d, J = 51,3 Hz, 1H), 8.03 (ddd, J = 9,6, 6.8, 2,6 Hz, 1H), 7,42 (d, J - 8.7 Hz, 1H), 7.21 - 6.98 (m, 1H), 6.86 - 6,57 (m, 1H), 3.65 - 3.43 (m, 3H), 3.22 - 2.92 (m, 3H), 1.40 (m, 9H); ⁱ⁹ F NMR (471 MHz, CDCIs) δ -115.40 (s), - 122.10 (s); ESIMS m/z 455 ([M + H] ^~ ), E ample 62; Preparation of /¥~(2,6~dsfluoro~3~nitrophenyl)~2 _f 2~difSuoro~ methylacetamide (C148)

To a solution of V-(2,6-difl uoro-3-nitrophenyl)-2,2-difluoroacetamide (C 193) (0,400 g, 1.59 mmol) in dry A^W-dimethylformamide ( 12 mL) cooled in an ice bath was added sodium hydride (60% oil dispersion, 0.076 g, 1 ,90 mmol). The slurry was stirred for 5 minutes i n the ice bath, The bath was removed and the reaction was stirred an additional 40 minutes. Iodomethane (0.099 mL, 1.59 mmol) was added , The reaction mixture was stirred at room temperature overnight. The reaction was quenched with water ( 15 mL) and diluted with ethyi acetate (40 mL), The phases were separated, and the organic layer was washed with 1 : 1 brine/water (4 x 20 mL) , The organic layer was poured through a phase separator to dry and then concentrated under reduced pressure to afford the title compound as a yellow oil (0.30 g, 71%) : Ή NMR (400 MHz, DMSO-c e) δ rotamers 8,45 (ddd, 3 = 9.5, 8.5, 5.7 Hz, 0.65H), 8.36 (ddd, J - 9, 5, 8.4, 5, 5 Hz, 0.35H), 7 ,69 - 7.52 (m, 1H), 7.05 (t, J = 52. 1 Hz, 0.35H), 6.43 (t, J = 51.6 Hz, 0.65H), 3.43 (d, J = 1.2 Hz, 1 H), 3.25 (s, 2H) ; ⁱ⁹ F NMR (376 MHz, DMSO-tfc) δ rotamers - 106,63 (d, J = 10,3 Hz), - 106, 82 - - 107.10 (m),

-120.60 - - 120,78 (m), - 120,98 (d, J = 10.4 Hz), - 124.26 - - 124.99 (m), - 124.80 - -125.41 (m), -126.78 (d, J = 3.4 Hz) ; EIMS m/z 266.

Example 63; Preparation of 2~bromo~N~(2 _J ,4~dsf!uorophenyi)~ ~rnethyf-5~ nitroben-iamide (C149)

2-Bromo-5-nitrobenzoic acid (0, 500 g, 2.03 mmol) and 4-di methylaminopyridi ne (0,273 g, 2.24 mmol) were sequentially added to a stirred mixture of 2,4-difluoro-/V- methylaniline (0,349 mL, 2.44 mmol) and l-ethyi-3-(3- dimethylaminopropyl)carbodiimide hydrochloride (0.584 g, 3.05 mmol) in

dichloromethane ( 13, 5 mL) at room temperature. The reaction was stirred at room temperature for 20 hours. The reaction mixture was diluted with dichloromethane and washed with saturated aqueous sodium bicarbonate followed by hydrochloric acid (1 N) , The organic phase was dried over magnesium sulfate, filtered, and concentrated.

Purification by flash column chromatography usi ng 0-25% ethyi acetate/hexanes as eluent provided the title compound as a beige solid (0.149 g, 19%) : ^J HNMR (500 M Hz, CDC ) δ 8.29 (d, J = 2.7 Hz, OH), 8.21 - 8.14 (m, OH), 8.07 (dd, J = 2.7, 1.4 Hz, 1H), 7.93 (dd, J = 8.8, 2.7 Hz, 1H), 7.86 (dd, J = 8.7, 6.2 Hz, OH), 7.61 (d, J = 8.8 Hz, 1H), 7.47 - 7.39 (m, OH), 7.30 (dt, J = 9.0, 4,5 Hz, 1H), 7,04 - 6,97 (m, OH), 6.83 - 6.72 (m, 2H), 3.45 (s, 4H), 3.19 (s, 1H); 19F NMR (471 MHz, CDCb) δ -106.76 , -108.81 (dt, J = 14,9, 7,9 Hz), -114.38 , -115,36 (q, J ^: -- 8.6 Hz); ESIMS m/z 373 ([M + H] ⁺ ).

Example 64: Preparation of 2-chSoro-/¥-(4-f!uorophen¾f!)"5-nstroben2:arf!!de (C150)

2-Ch!oro-5-nitrobenzoic acid (0.250 g, 1.24 mmo!) and 4-dimethylaminopyridine (0,197 g, 1.61 mmol) were sequentia!iy added to a stirred mixture of 4-fluoroaniline (0.141 mL, 1.49 mmol) and l-ethyl-3-(3-dimethylaminopropyl)carbodiimide

hydrochloride (0.357 g, 1.86 mmol) in 1,2-dichloroethane (12,4 mL) at room

temperature. The reaction was stirred at room temperature for 20 hours. The reaction mixture was diiuted with dichioromethane and washed with saturated aqueous sodium bicarbonate followed by hydrochloric acid (1 N) to provide the titie compound as a ilght brown solid (0.188 g, 49%): ^l tf NMR (400 MHz, CDCb) δ 8,59 (d, J = 2,7 Hz, 1H), 8,26 (dd, J = 8.8, 2.8 Hz, 1H), 7.90 (s, 1H), 7,66 (d, J = 8.8 Hz, 1H), 7.64 - 7,57 (m, 2H), 7.15 - 7,05 (m, 2H); ⁱ⁹ F NMR (376 MHz, CDCb) δ -116,03; ESIMS m/z 295 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 64;

2-ChSoro~i¥~(2 _f 4~d!ffuorophenyS)~S~nitrobenzamide (C1S1)

Isolated as a light purple solid (1.48 g, 64%): ⁵ H NMR (400 MHz, CDC 13) δ 8.68 (d, J - 2.7 Hz, 1H), 8.40 (td, J - 9.1, 6.7 Hz, 1H), 8.30 (dd, J = 8.8, 2.7 Hz, 1H), 8.09 (s, 1H), 7.69 (d, J = 8.8 Hz, 1H), 7.04 - 6.89 (m, 2H); ¹⁹ F NMR (376 MHz, CDCb) δ - 113,04 (d, J = 5.0 Hz), -125.45 (d, J = 5,1 Hz); ESIMS m/z 313 ([M + H] ).

2-ChSoro-W-(2-cyano-4-f!ujrophenyS)-5-nitrobenzamide (C152)

Isolated as a white solid (0.439 g, 55%): *H NMR (400 MHz, DMSO-de) δ 11.06 (s, IH), 8,52 (d, J = 2.8 Hz, IH), 8.38 (dd, J = 8,8, 2.8 Hz, IH), 8.02 - 7,86 (m, 2H), 7.83 - 7,61 (m, 2H); ¹⁹ F NMR (376 MHz, DMSG-cfe) δ -113.90; ESIMS m./z 320

([M÷H] ⁺ ).

tert-Butyl (4~(2~chloro~5~nitroben2amido)~3~m8thySphenvl)carbamat8 (C153)

Isolated as a yellow solid (2,19 g, 67%): mp 195 - 200 °C; ^J H NMR (300 MHz, DMSO-de) δ 10,06 (s, IH), 9.34 (s, IH), 8.45 (d, J - 2.7 Hz, IH), 8.33 (dd, 3 - 8.8, 2. Hz, IH), 7,88 (d, J = 8.8 Hz, IH), 7.43 - 7.24 (m, 3H), 2,24 (s, 3H), 1.48 (s, 9H); ESIMS m/z 404 ([M-H] ),

ferf-Buty-M-({fert-butoxy)carbonyt)-/¥-{3-(2-chSoro-5-ni troben2:amido}-2,4- dif uoropheny!)carbamate (C154)

Isolated as a yellow oil (5,2 g, 66%): NMR (400 MHz, DMSO-de) δ 10,69 (s,

IH), 8.51 (d, J = 2.7 Hz, IH), 8.35 (dd, J = 8,8, 2.8 Hz, IH), 7.97 - 7.79 (m, 2H), 7,30 (td, J = 9,3, 1.7 Hz, IH), 1.41 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-fe) δ -123,43, - 127,02 (d, J = 2.0 Hz); ESIMS m/z 526 ([M-H] ^" ).

Example 65; Preparation of tert~Butyf-W~tert~butoxycarbony!~M~[3~[(2~chSoro~ 3-fluoro~5~nitroben2oyl)amino]~2 _f 6~difSuorophenyl]carbamate (C155)

To a solution of 2-chloro-3-fluoro-5-nitrobenzoic acid (C206) (1,81 g, 8.25 mmoi) and terf-butyl v-(5-amino-2,6-difluorophenyl)-/V-tert-butoxycarbonyl carbamate (C182) (2.84 g _f 8.25 mmo!) In ethyl acetate (41 mL) were added pyridine (1.96 g, 24.7 mmoi) followed by a 50% solution of 2,4,6-tripropyl-l,3,5,2,4,6-trioxatnphosphinane 2,4,6-trioxide (9.82 mL, 16.5 mmol) in ethyl acetate, and the resulting gold solution was warmed to 48 °C and stirred for 12 hours. The reaction mixture was concentrated under reduced pressure to give a viscous, gold oil. The oil was dissolved in minima!

dichloromethane (~8 mL) and adsorbed to Celite®. The adsorbed materia! was purified by automated flash chromatography using a gradient of 0-40% ethyl acetate in hexanes to give the title compound as a white solid (2.095 g, 83%); mp 167 - 169 °C; *H NMR (400 MHz, DMSO-de) δ 10,76 (s, 1H), 8.52 (dd, J = 8,8, 2.6 Hz, 1H), 8.43 (dd, J = 2,6, 1.4 Hz, 1H), 7.89 (td, J = 8,9, 5.8 Hz, 1H), 7.31 (td, J = 9,3, 1.8 Hz, 1H), 1.41 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-G%) δ -109.64, -123,26, -127.07, -127.08; HRMS-ESI (m/z) [M ⁺ ]÷ ca!cd for CZBHZBC!FB BO?, 545,1177; found, 545,1172.

Example 66: Preparation of 2 _f 6~dichloro~M~(2 _f 4~diffuorophenyS}~3~

nitrobenzamide (C156)

Step I: To a suspension of 2,6-dich!oro-3-nitrobenzoic acid (0,15 g, 0,64 mmol) in 1,2-dich!oroethane (10 mL) were added two drops of Λ/,/V-dimethylformamide followed by the dropwise addition of oxa!y! dich!oride (0,40 g, 0.27 mL, 3.2 mmo!), and the resulting !ight-ye!!ow solution was stirred at room temperature for 16 hours. The solvent and excess oxaiy! dich!oride were evaporated under reduced pressure, and the resulting gold oil was dissolved in 1,2-dichloroethane (10 mL) and concentrated (repeated 2x) to give the intermediate acid chloride as a gold ol! which was used without purification.

Step 2; To a solution of 2,4-difluoroanii!ne (0,082 g, 0.64 mmol) and W-ethy!-W- isopropylpropan-2-amine (0.17 g, 1.34 mmo!) in l,2-dichloroethane(l mL) was added a solution of the freshly prepared acid chloride, 2,6-dichloro-3-nitrobenzoyl chloride (0.162 g, 0.64 mmol) in 1,2-dichloroethane (1 mL) dropwise at 0 °C. The resulting light-orange solution was warmed to 50 °C and stirred for 8 hours. The reaction mixture was adsorbed to Ceiite ^® and purified by automated flash chromatography using a gradient of 0-60% ethyl acetate in hexanes as eiuent to give the title compound as a tan solid (0, 171 g, 75%) : mp 199 - 202 °C; ^'! H NMR (500 MHz, DMSO-de) δ 10.83 (s, 1H), 8,21 (d, J = 8.8 Hz, 1H), 7.94 (td, J = 8.9, 6, 1 Hz, 1H), 7,88 (d, J = 8.8 Hz, 1H), 7.41 (ddd, J = 10.9, 9,0, 2,9 Hz, 1H), 7, 17 (dddd, J = 9,5, 8.4, 2,9, 1.4 Hz, 1H); ¹⁹ F NMR (471 MHz, DMSO-de) δ -112.94,

-112,95, -112,96, -112,96, -112,97, -112,97, -112.98, -112.99, -113.00, -118.60, - 118.62, -118.62, -118,64, -118,64, -118,66; ESIMS m/z 347 ([M + H]÷).

The following compounds were prepared In like manner to the procedure outlined In Example 66:

J¥-(4-Acetamsdophen -2,6-dschSoro-3-nitrobenzamide (C157)

Isolated as a light-yellow solid (0, 153 g, 63%) : mp 268 - 270 °C; *H NMR (400 MHz, DMSO-de) δ 10.82 (s, 1H), 9,97 (s, 1H), 8.20 (d, J = 8,8 Hz, 1H), 7,89 (d, J = 8.8 Hz, 1H), 7.58 (s, 4H), 2.04 (s, 3H); IR (thin film) 3640, 3250, 3054, 1656, 1527, 1310, 827, 706 cm ^"1 ; ESIMS m/z 366([M-2H] ^" ).

2 _? 6-Dich!oro~Af~(4~ffuorophenyf )~3-nstrobeniarnide (€158)

Isolated as a light-orange solid (0.148 g, 70%) : mp 211 - 214 °C; *H NMR (400 MHz, DMSO-cfc) δ 10.98 (s, 1H), 8.22 (d, J = 8,8 Hz, 1H), 7.90 (d, J = 8.8 Hz, 1H), 7,77 - 7,63 ( rs, 2H), 7,34 - 7, 11 (m, 2H) ; ¹⁹ F NMR (376 MHz, DMSO-c e) δ -117.60; ESIMS m/z 329 ([M + H]-).

2 _? 6-Dich!oro~3~nitro~/^~pheny!benzamide (C159)

Isolated as a light-orange solid (0, 173 g, 86%) : mp 180 - 183 °C; ^v rt NMR (500 MHz, DMSO-cfc) δ 10,90 (s, 1H), 8.22 (d, J = 8,7 Hz, 1H), 7.90 (d, J = 8.7 Hz, 1H), 7,70 - 7.64 (m, 2H), 7.42 - 7.34 (m, 2H), 7,22 - 7,08 (m, 1H); ESIMS m/z 311 ([M+H] ⁺ ) . W~(4-Aminophen¾fl)-2 _i 8~dschforo~^~methyS~3~nitrobenzamide (C160)

Isolated as a green solid (0.085 g, 36%): mp 176 - 180 °C; NMR (500 MHz, DMSO-cfc) δ 7.93 (d, J = 8,8 Hz, 1H), 7,63 (d, J = 8,7 Hz, 1H), 7,02 - 6.97 (m, 2H), 6.41 - 6.35 (m, 2H), 5.23 (s, 2H), 3.30 (s, 3H); ESIMS m/z 340 ([M + H] ⁺ ).

ferf~Butyf~M~ierf~butoxycarbony!~M~[3~[{2 _f 6~dichforo~3~nitrobenioyl)amino]~ 2,6-dif!uorophenyf]carbamate (C161)

Isolated as a light-orange solid (0.302 g, 78%): mp 164 - 167 °C; *H NMR (500 MHz, DMSQ- e) δ 10.93 (s, 1H), 8,23 (d, J = 8.8 Hz, 1H), 7.97 - 7,84 (m, 2H), 7,31 (td, J = 9,3, 1.7 Hz, 1H), 1,40 (s, 18H); ⁱ⁹ F NMR (471 MHz, DMSO-ds) δ -123,11, -123,12, -123.14, -127.55, -127.57; ESIMS m/z 560 ([M-H] ^" ).

2 _? 6-Dif!uoro~3~nitro-/¥~phenylbeni:amsde (C162)

Isolated as a yellow solid (0.161 g, 90%): mp 161 - 163 °C; *H NMR (500 MHz, DMSO-ds) δ 10,98 (s, 1H), 8,42 (td, J = 9,0, 5.6 Hz, 1H), 7,71 - 7,63 (m, 2H), 7,56 (ddd, J = 9.4, 7.9, 1.5 Hz, 1H), 7.44 - 7.35 (m, 2H), 7.24 - 7.14 (m, 1H); ¹⁹ F NMR (471 MHz, DMSO-ce) δ -102.54, -102.56, -102.56, -102.57, -102.58, -102.60, -117.46, - 117,48, -117,51; ESIMS m/z 279 ([M÷H] ⁺ ).

2,6~Difluoro~i¥~(4~ffuorophenyS}~3~nitroben2amide (C163)

Isolated as a light-orange solid (0,178 g, 93%): mp 158 - 160 °C; *H NMR (500 MHz, DMSO-ce) δ 11.05 (s, 1H), 8.43 (td, J - 9.0, 5.6 Hz, 1H), 7.76 - 7.65 (m, 2H), 7.56 (ddd, J = 9.5, 8.0, 1.5 Hz, 1H), 7.25 (t, J = 8.9 Hz, 2H); ¹⁹ F NMR (471 MHz, DMSO- s) δ -102.47, -102.48, -102.49, -102.50, -102.50, -102.52, -117.37, -117,39, 117,40, -117.41, -117.42, -117.43, -117.44; ES!MS m/z 297 ([M + Hj ⁺ ).

W-{4-Acetamsd3phenyi}-2j6-dsfSuoro-3-nitrobenxamsde (C164)

Isolated as a white solid (0.041 g, 19%): mp 251 - 255 °C; ¹ H NMR (500 MHz, DMSO-ds) δ 10,90 (s, IH), 9.97 (s, IH), 8.41 (td, J = 9.0, 5,6 Hz, IH), 7.59 (s, 4H), 7,54 (ddd, J = 9.3, 7.9, 1.4 Hz, IH), 2.04 (s, 3H); ¹⁹ F NMR (471 MHz, DMSO-de) δ - 102,50, -102,52, -102.54, -102.55, -117.45, -117.47, -117.49; ESIMS m/z 336

([ + H] ⁺ ).

ferf-Buty M-fert-butoxyca

2 _f 6~difSuorophenyl]carbamate (C16S)

Isolated as a pale-yellow solid (0.165 g, 48%): mp 163 - 165 °C; *H NMR (500 MHz, DMSO-tfc) δ 10.98 (s, IH), 8.43 (td, J = 9.0, 5.6 Hz, IH), 7.87 (td, J = 8.8, 5.7 Hz, IH), 7.55 (ddd, J = 9.4, 8.0, 1.4 Hz, IH), 7.31 (td, J = 9,2, 1.7 Hz, IH), 1.40 (s, 18H); ¹⁹ F NMR (471 MHz,DMSO-ds) δ -102.41, -102.43, -102.45, -102.46, -117.12, -117.14, - 117,16, -122.89, -122.91, -122.93, -127.37, -127,39; ESIMS m/z 528 ([M-H] ).

2 _? 6-DschSoro-3-nitro-/¾'-{2 _i 2 _? 3 _i .3 _f 3-pentafluiropripy ben2:amsde (C166)

Isolated as a white solid (0,095 g, 64%): mp 139 - 142 °C; ¹ H NMR (400 MHz, CDC ) δ 7.85 (d, J = 8.8 Hz, IH), 7.50 (d, J = 8.8 Hz, IH), 6.29 (s, IH), 4.18 (td, J = 14,9, 6.4 Hz, 2H); ¹⁹ F NMR (376 MHz, CDC ) δ -84.17, -121.45; ESIMS /z 367

([ + H] ⁺ ).

2 _? 6-DschliQro-W-ethyh3-nitrobenzami!de (C167)

Isolated as a yellow solid (0.108 g, 61%) : mp 104 - 108 °C; *H NMR (400 MHz, CDCb) δ 7,80 (d, J = 8.7 Hz, 1H), 7.47 (d, J = 8,8 Hz, 1H), 5,91 (s, 1H), 3.54 (qd, J = 7.3, 5.8 Hz, 2H), 1.29 (t, J = 7.3 Hz, 3H) ; IR (thin film) 3253, 3086, 2980, 1819, 1645, 1564, 1518, 1344, 928, 698 cm ^"1 ; ESIMS m/z 261 ([M-H] ^" ) .

~nitr

Isolated as a yellow solid (0.108 g, 62%) : mp 104 - 108 °C; *H NMR (400 MHz, CDCb) δ 8.16 (ddd, J = 9.3, 8.2, 5.5 Hz, 1 H), 7.10 (ddd, J = 9.4, 7.7, 1.8 Hz, 1H), 6.08 (s, 1H), 3.52 (qd, J = 7,3, 5.7 Hz, 2H), 1.27 (t, J = 7.3 Hz, 3H) ; ¹⁹ F N MR (376 MHz, CDC! ?,) δ - 100.08, - 100, 10, - 114,72, -114,75; IR (thin film) 3240, 3087, 2996, 1713, 1620, 1531, 1347, 1298, 1028, 843 cm ^"1 ; ESIMS m/z 231 ([M + H] ⁺ ) .

-propyf benzamide (C169):

Isolated as a yellow solid (0.158 g, 88%) : mp 126 - 129 °C; *H NMR (400 MHz, DMSO-cfc) δ 8.82 (t, J = 5,8 Hz, 1 H), 8, 12 (d, J = 8.8 Hz, 1H), 7.81 (d, J = 8.8 Hz, 1H), 3.23 (tcl, J - 6,9, 5.7 Hz, 2H), 1.54 (h, J - 7.2 Hz, 2H), 0.93 (t, J - 7.4 Hz, 3H) ; ESIMS m/z 277 ([M + H] ⁺ ) .

2,6~Dich!oro~/¥~{2~ffuoroethyl)~3~nitrobenzaniide (C170)

Isolated as a cream-colored sol id (0.154 g, 84%) : mp 148 - 150 °C; ^J H NMR (500 MHz, DMSO-ds) δ 9, 14 (t, J = 5.7 Hz, 1H), 8.14 (d, J = 8.8 Hz, 1H), 7.82 (d, _7 = 8.7 Hz, 1H), 4.55 (dt, J - 47.4, 4.9 Hz, 2H), 3.65 - 3.53 (m, 2H) ; ⁱ⁹ F NMR (471 MHz, DMSO-ds) δ 20.28, 20,23, 20. 18, 20. 12, 20.07, 20.06, 20.02, 19.96; ESIMS m/z 281 ([Μ + ΗΓ) ,

2,6-Dschtoro-3-nitro-/¥-{2,2,2-trifluoroethvt)benxamsde (C171)

Isolated as a pale-yellow solid (0.182 g, 88%): mp 182 - 184 °C; ^X H NMR (500 MHz, DMSO-/e) δ 9.57 (t, J = 6.3 Hz, 1H), 8.18 (d, J = 8.7 Hz, 1H), 7.85 (d, J = 8,8 Hz, 1H), 4.17 (qd, J = 9.7, 6.3 Hz, 2H); ⁱ⁹ F NMR (471 MHz, DMSO-c/e) δ -70.07, -70.09, - 70.11; ESIMS m/z 315 ([M-H] ^" ).

2 _? 6-Dich!oro~3~nitro~^~( ~trifSuoropropy!)beniiam!de (C172)

Isolated as a pale-yellow solid (0.186 g, 86%): rrtp 128 - 130 °C; ^l NMR (500 MHz, DMSO-cfc) 69.14 (t, J = 5.8 Hz, 1H), 8.15 (d, J = 8.7 Hz, 1H), 7.82 (d, J = 8.8 Hz, 1H), 3.51 (td, J = 6.8, 5,7 Hz, 2H), 2,61 - 2.52 (m, 2H); ¹⁹ F NMR (471 MHz, DMSO-de) δ -63.89, -63.91, -63.94; ESIMS m/z 331 ([M + H] ⁺ ),

~{3~chSoroprop¾ff)-3-nstroben-iaf

Isolated as a yellow solid (0.180 g, 89%): mp 116 - 120 °C; *H NMR (500 MHz, DMSO-cfe) δ 8,94 (t, J = 5,7 Hz, 1H), 8,14 (d, J = 8.7 Hz, 1H), 7.82 (d, J = 8.7 Hz, 1H), 3.72 (t, J = 6,5 Hz, 2H), 3,40 (q, J = 6.4 Hz, 2H), 1.98 (p, J = 6.6 Hz, 2H); ESIMS m/z 311 ([M + H] ⁺ ),

2 _? 6-Difluoro~3~nitro-/¥~propy!benz:amsde (C174)

Isolated as a light-yellow solid (0.149 g, 95%): mp 85 - 88 °C; ^! H NMR (500 MHz, DMSO-cfc) δ 8.93 - 8.83 (m, 1H), 8.33 (td, J = 9.0, 5,6 Hz, 1H), 7,46 (ddd, J = 9.4, 8.0, 1.5 Hz, 1H), 3.24 (td, J - 6.8, 5.6 Hz, 2H), 1.52 (h, J - 7,2 Hz, 2H), 0,91 (t, J - 7.4 Hz, 3H); ¹⁹ F NMR (471 MHz, DMSO-cg) δ -102.84, -102.85, -102.87, -102.88, - 102,89, -117.84, -117.86, -117.88; ESIMS /z 245 ([ +H] ⁺ ).

2,6-Difluoro~i¥-(2~ffuoroethyf)-3~n!trobenzamide (CI 75}

Isolated as a yeiiow soiid (0.135 g, 82%): mp 95 - 99 °C; H NMR (500 MHz, DMSG-ds) δ 9.20 (t, J = 5.6 Hz, 1H), 8.35 (td, J = 9,0, 5.6 Hz, 1H), 7.47 (ddd, J = 9, 8.0, 1.6 Hz, 1H), 4.54 (dt, J = 47.5, 4,9 Hz, 2H), 3.66 - 3,54 (m, 2H); ¹⁹ F NMR (471 MHz, DMSO-ce) δ 19,65, 19.59, 19.55, 19.53, 19.49, 19.45, 19.43, 19.39, 19.33, - 102.68, -102.70, -102.71, -102.71, -102.72, -102.74, -117.56, -117,58, -117.60;

ESIMS m/z 249 ([M + H] ⁴ ),

2,6-Difluoro~3~nitro-/¥~(2,2 _f 2~trifSuoroethvl)benzani!de (C176)

Isolated as a white solid (0,175 g, 97%): mp 137 - 139 °C; ^J H NMR (500 MHz, DMSO-cfc) δ 9,64 (t, J - 6,3 Hz, 1H), 8,39 (td, J - 9.0, 5.6 Hz, 1H), 7.50 (ddd, J = 9.5, 8.0, 1.5 Hz, 1H), 4.19 (qd, J = 9.6, 6.3 Hz, 2H); ⁱ⁹ F NMR (471 MHz, DMSO-de) δ -70.70, -70.72, -70.74, -102.73, -102.74, -102.75, -102.75, -102.76, -102.76, -102.77, - 102,78, -117,46, -117.48, -117.50; ESIMS m/z 283 ([M-H] ^" ).

2,6-Dsfiuoro-3-nitro-/¥-{3,3 _f 3-trifSuoropropy }benzamide (C177)

Isolated as a pale-yellow solid (0.167 g, 87%): mp 108 - 110 °C; *H NMR (500 MHz, DMSO-cs) δ 9.18 (t, J - 5.8 Hz, 1H), 8.35 (td, J - 9.0, 5.6 Hz, 1H), 7,47 (ddd, J - 9,5, 8.1, 1.5 Hz, 1H), 3,53 (td, J = 6,6, 5,6 Hz, 2H), 2,60 - 2.51 (m, 2H); ⁱ⁹ F NMR (471 MHz, DMSO-tfc) δ -63.83, -63.86, -63,88, -102,67, -102.69, -102.70, -102.72, -117.59, -117.61, -117.63; ESIMS m/z 299 ([M + H] ⁺ ).

2 _i 6-Dsfiuoro-3-n!tro-Af-{ -pentafluoripropvl)ben2:amide (Ci7S)

Isolated as a white solid (0.177 g, 83%): mp 143-145 °C; *H NMR (500 MHz, DMSO-de) δ 9,66 (t, J = 6,3 Hz, 1H), 8,39 (td, J = 9.0, 5,6 Hz, 1H), 7,50 (ddd, J = 9.5, 8.1, 1.6 Hz, 1H), 4.24 (td, J = 15.2, 6,3 Hz, 2H); ⁱ⁹ F NMR (471 MHz, DMSO-de) δ - 83.41, -102,65, -102.66, -102.68, -102.70, -117.38, -117.40, -117.42, -120.07, - 120.10, -120,14; IR (thin film) 3282, 3100, 2973, 1677, 1541, 1224, 1033, 730 cm ^"1 ; ESIMS m/z 333 ([M-H] ),

W-(3-Chi jropropv'S)-2 _i .6-difluoro-3-nitrobenzamide (C179)

Isolated as a yellow solid (0.137 g, 77%): mp 84 - 87 °C; ^"! H NMR (500 MHz, DMSO- e) δ 9.00 (t, J = 5.7 Hz, 1H), 8,35 (td, J = 9.0, 5.6 Hz, 1H), 7.47 (ddd, J = 9.5, 8.0, 1.5 Hz, 1H), 3.70 (t, J = 6.5 Hz, 2H), 3.41 (td, J = 6.7, 5.5 Hz, 2H), 1.97 (p, J = 6.6 Hz, 2H); ⁱ⁹ F NMR (471 MHz, DMSO-ds) δ -102.82, -102.82, -102.83, -102.84, - 102,85, -117,76, -117.78, -117.81; ESIMS m/z 279 ([M+H] ⁺ ).

ferf-Buty {3-(2-chloro-3-fiuoro-5-nitroben¾am!do)-2 _f 4- dif uorophenyS)carbamate (CI80)

Isolated as an off-white solid (0.590 g, 100%): mp - 202-204 °C (dec); *H NMR (400 MHz, DMSO-tfc) δ 10.63 (s, 1H), 9.06 (s, 1H), 8.51 (dd, J = 8.8, 2,6 Hz, 1H), 8,40 (dd, J = 2.6, 1.4 Hz, 1H), 8.07 (t, J = 8.3 Hz, 1H), 7.42 (t, J = 10.4 Hz, 1H), 1.46 (s, 9H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -109.72, -122.28, -123.56; ESIMS /z 544 ([M-H] ^' )■

Example 67; Preparation of tert-butyS-/¥-({i"erf-butox¥}carbonvS)-W-(4-amsno- 3 _f 5-dif!uorophenyi)carbamate (CI81)

To a solution of ferf-«butyl~A-((terf-butoxy)carbonyl)~(3,5-difiuoro~4- nitrophenyl)carbamate (C189) (1,75 g, 4.67 mmol) in ethyl acetate (30 mL) was added 5% palladium on carbon (0,498 g, 0,234 mmol). The reaction mixture was stirred vigorously overnight at room temperature under a balloon of hydrogen. The reaction mixture was filtered through a pad of Ceiite ^® and washed with ethyl acetate. The filtrates were concentrated under reduced pressure to afford the title compound as an off-white solid (1,57 g, 98%): ^V NMR (400 MHz, DMSO-ds) δ 7.07 (ddd, J = 11.4, 8.9, 2.8 Hz, 1H), 6.79 (dd, J = 9.3, 2.4 Hz, 1H), 4.87 (s, 2H), 1,36 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -128.55, -129.75.

The following compounds were prepared in like manner to the procedure outlined in Exampie 67:

tert-Butyl /¥~(3~amino~2 _f 6~difuoro~pheny!)~/¥~tert~but03ycarbonyl~carbamate (C182)

Isoiated as a white solid (5,06 g, 100%): *H NMR (400 MHz, DMSO-de) δ 6.87 (td, J - 9.3, 1.7 Hz, 1H), 6.74 (td, J = 9.4, 5.7 Hz, 1H), 5.12 (s, 2H), 1.39 (s, 18H); ⁵⁹ F NMR (376 MHz, DMSO-ds) δ -137.96 (d, J - 3.7 Hz), -141.10 (d, J - 3.7 Hz); ESIMS m/z244 ([M-BOC]-).

fert-Buty /y-((terf-butoxv)carbonyS)- -(S-amino-2 _f - dif!uarophenyl)carbamate (C183)

Isoiated as a cream colored solid (1.05 g, 88%): *H NMR (400 MHz, CDC ) δ 6.82 (dd, J = 10.5, 9.3 Hz, 1H), 6.60 (dd, J = 9.1, 7.5 Hz, 1H), 3.59 (s, 2H), 1.43 (s, 18H); ¹⁹ F NMR (376 MHz, CDCb) δ -131,04 (t, J = 2.2 Hz), -131.38 (d, J = 2,0 Hz); ESIMS m/z 245 ([M-C ₅ H ₉ 0 ₂ +H] ⁺ ),

fert-Butyl (4-a inQ-3- ethy§phenyi)carbamate (C184) Isolated as a light pink solid (12.4 g, 87%); ^"! H NMR (400 MHz, DMSO-d ₆ ) δ 8.72 (s, 1H), 7.01 (s, 1H), 6.93 (d, J = 8.5 Hz, 1H), 6.49 (d, J = 8.4 Hz, 1H), 4,49 (s, 2H), 2.00 (s, 3H), 1.44 (s, 9H); ESIMS m/z 223 ([M + H] ⁺ ),

ferf-Buty-i¥-({fert-butoxy}carbonyt (4-amsnj-2 _i .6-difluorophenyS}carbamate (C185)

Isolated as an off-white solid (1.5 g, 73%): H NMR (400 MHz, DMSO-cfeJ δ 6,28 - 6,18 (m, 2H), 5,83 (s, 2H), 1,37 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO-ce) δ -122,91; ESIMS m/z 345 ([M÷H] ⁺ ),

W~{3~Amino~2,6~diffuoropheny!)~2 _? 2-dif!uoroacetamsde (C186)

Isolated as a light brown solid (0,91 g, 98%): H NMR (400 MHz, DMSO-ds) δ 10.50 (s, 1H), 6,88 (td, J = 9.3, 1.9 Hz, 1H), 6,72 (td, J = 9,3, 5.5 Hz, 1H), 6.49 (t, J = 53.2 Hz, 1H), 5.58 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-A) δ -125.61, -135.65 (d, J = 3,4 Hz), -138.69 (d, J = 3,5 Hz); EIMS m/z 222,

W~{3-Amino~2,6-difluoropheny!)-2 _? 2-dif!uoro-/¥~methySacetamsde (C187)

Isolated as a light yellow oil (0.26 g, 96%): ^J H NMR (400 MHz, DMSO-de) δ rotamers 7.00 (td, J = 9,3, 1,7 Hz, 1H), 6,85 (td, J = 9.4, 5.7 Hz, 1H), 6.24 (t, J = 52, Hz, 1H), 5,32 (s, 2H), 3.33 (d, J = 2,7 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ rotamers -124,15 (dd, J - 16.1, 2,9 Hz), -137.89 - -138.92 (m), -140.84 - -141.99 (m); EIMS m/z 236.

ferf-Butyf (3-(5~aminG-2~chloro~3-f!uQrobenramido}~2 _f 4~

diffuorophenvl)carbamat8 (C188)

Isolated as a tan powder (0.563 g, 100%): H NMR (400 MHz, CDCb) δ 8.99 (t, J = 8.5 Hz, 1H), 8.08 (br s, 1H), 6,97 - 6.89 (m, 2H), 6.59 (dd, J = 10.4, 2.7 Hz, 1H), 6.55 (br s, 1H), 3.98 (br s, 2H), 1.54 (s, 9H); ¹⁹ F NMR (376 MHz, CDCb) δ -112.06, - 131,58, -132,13; ESIMS m/'z 414 ([M-H] ^" ),

Example 68: Preparation of i-ert-Buty-W-({£'ert-butoxv)carbonyS)-(3 _i .S-dsfluori- 4-n!trophenyl)carbamate (C189)

To a solution of 3,5-difluoro-4-nitroaniline (1.0 g, 5.74 mmoi) in dichloromethane (25,0 mL) was added di-£ert- butyl dicarbonate (2.63 g, 12.1 mmol) followed by 4- dimethylaminopyridine (0,070 g, 0.574 mmol). The reaction mixture was stirred for 48 hours at room temperature. The reaction mixture was quenched with water and poured through a phase separator. The organic layer was concentrated. Purification by flash column chromatography using 0-20% ethyl acetate/hexanes as eiuent afforded the title compound as a yellow solid (1.79 g, 83%): *H NMR (400 MHz, CDCb) δ 7.04 (ddd, J = 9.7, 8.0, 2.7 Hz, 1H), 6,90 (ddd, J = 8.2, 2.7, 1.9 Hz, 1H), 1.43 (s, 18H); ¹⁹ F NMR (376 MHz, CDCb) δ -133.35 (d, J = 23.5 Hz), -137.44 (d, J = 23.4 Hz); ESIMS m/z 375 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 68:

tert-Buty~¥~({£ ^, ert~but>3y)carbonyS)~M-(2 _f 6~difSuoro~3~nitrophenvl}carbamat8 CC190)

Isolated as a white foam (5.2 g, 69%): ^l NMR (300 MHz, CDCb) δ 8.14 (ddd, J = 9,2, 8.1, 5.5 Hz, 1H), 7.10 (ddd, J = 9.7, 8,0, 2.0 Hz, 1H), 1.45 (s, 18H); ¹⁹ F NMR (376 MHz, CDCb) δ -105.95 (dd, J = 10,9, 2.7 Hz), -119.53 (d, J = 10.6 Hz); ESIMS m/z 397 ([M + Na] ⁺ ).

fert-Buty W-((tert-butoxv)carbony -^-(2 _f 4-dsfluoro-S-n!trophenvS)carbamate (C191)

Isolated as a white solid (1.2 g, 56%): ^J H NMR (400 MHz, CDC 13) δ 8.05 (t, J - 7.7 Hz, 1H), 7.11 (dd, J - 10.2, 8.9 Hz, 1H), 1.46 (s, 18H); ¹⁹ F NMR (376 MHz, CDCb) δ -105.08 (dd, J = 14.8, 2.2 Hz), -111,35 (dd, J = 14.6, 2,3 Hz); ESIMS /z 397

([ + Na] ⁺ ).

fert-Buty / ^, -((terf-butoxv)carbonyS)-{2,6-dsf!uoro-4-r!!trophenyi} carbamate

CC192)

Isolated as a light yellow solid (2.0 g, 84%): H NMR (400 Hz, DMSQ-cfeJ δ 8,33 - 8,24 (m, 2H), 1,40 (s, 18H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -115.68; ESIMS m/z 374 ([M-H]-).

Example 69; Preparation of W-(2 _f 6-dsfluoro-3-n!tropheny!)-2 _i ,2- diffuoroacetamsde (C193)

To a solution of 2 _f 6-difiuoro-3-nitroaniiine (1,00 g, 5,74 mmol) in

dichloromet ane (2.0 mL) stirred at room temperature was added trlethylamine (1.20 mL, 8.62 mmol) and 2,2-dlfiuoroacetic anhydride (1,30 g, 7.47 mmol). The reaction mixture was stirred at room temperature for 18 hours. The mixture was then loaded onto a Ceiite ^® cartridge and purified by column chromatography using 0-40% ethyl acetate/hexanes as eluent to afford the title compound as a white solid (1,50 g, 100% yield): ^l NMR (400 MHz, DMSO-ds) δ 11.07 (s, 1H), 8,29 (ddd, J = 9.5, 8,4, 5.5 Hz, 1H), 7.53 (td, J = 9.2, 1,9 Hz, 1H), 6,59 (t, J = 53.0 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO- de) δ -105,42 (d, J = 10.7 Hz), -120,10 (d, J = 10,6 Hz), -125.98; EIMS /z 252.

Example 70: Preparation of -{3-amino-2-ch!oro-6-f!uorophenvl)acetam!de (C194)

Step 1: Preparation of ~(2-ch!Gro™6~fiuorophenyi)aceta ide. Acetic anhydride (10 g, 99 mrnoi) was added dropwlse to a stirred solution of 2-chloro-6- f!uoroaniline (12.5 g, 86 mmol), in glacial acetic acid (50 mL), The resulting gold soiution was heated at 90 °C for 2 hours, then cooled and quenched with water (500 mL), The resulting solid was collected by vacuum filtration, washed with water (100 mL) and hexanes (100 mL) and dried in vacuo at 40 °C to a constant weight to give the title compound as a tan solid (14,87 g, 88%): *H NMR (400 MHz, CDC 13) δ 7.86 (s, 1H), 7,05 (dt, J - 63.2, 8.4 Hz, 3H), 2,13 (s, 3H); ESIMS m/z 188 ([M + H] ⁺ ).

Step 2: Preparation of i¥~(2-chforo~6~ffuoro~3-nitrophenyf)acetamid8, Sodium nitrate (4.53 g, 53,3 mmol) dissolved in water (5 mL) was added dropwlse to a stirred soiution of A-(2-chloro-6-fiuorophenyi)acetamide (5 g, 26,7 mmol), in

concentrated sulfuric acid (10 mL) at -10 °C. Upon completion of the addition, the resulting yellow solution was stirred at 0 °C for 30 minutes, then warmed to and stirred at room temperature for another 12 hours. The reaction mixture was poured into water (~ 250 mL) and the resulting solid was coiiected by vacuum filtration, Recrystallization from acetonitriie gave the title compound as a light tan solid (3,2 g, 49%): *H NMR (400 MHz, DMSO-tfe) δ 10.07 (s, 1H), 8,12 (dd, J = 9,2, 5.0 Hz, 1H), 7.70 - 7.55 (m, 1H), 2.12 (s, 3H); ESIMS m/z 233 ([M + H] ⁺ ).

Step 3: Preparation of i¥-(3~amino~2~chforo~6~f!uorophenv!)acetamide. Iron powder (325 mesh; 2, 16 g, 38,7 mmol) was added to a sti rred sol ution of ethanoi (50 mL) and concentrated hydrochloric acid (0,37 mL, 3.87 mmol). The suspension was heated at 65 °C for 1 hour and then cooled to 55 °C. A solution of ammonium chloride (1 ,49 g, 27.0 mmol) in water (5 mL) was added, fol lowed by /V-(2-chloro-6-fluoro-3- nitrophenyi)acetamide (1.8 g, 7.74 mmol) . The reaction mixture was heated to 60 °C for 8 hours, cooled, and filtered through a pad of Ceiite ^® . The filtrate was extracted with ethyl acetate (3 x 50 mL) . The combined organic extracts were washed with water and brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure on a rotary evaporator. Purification by silica gel flash chromatography gave the title compound as a tan solid (1.2 g, 72%) ; ^'! H N MR (400 MHz, DMSO-d ₆ ) δ

9.51 (s, 1H), 6,96 (t, J = 9, 2 Hz, 1H), 6,71 (dd, J = 9, 0, 5, 1 Hz, 1H), 5,23 (s, 2H), 2.03 (s, 3H); ESIMS m/z 203 ( [M + H] ⁺ ) .

Example 71 : Preparation of 3-amino-2 _f 6-dsfluorophenv acetate (C I95)

3-Amino-2,6-dif!uorophenoi (0.074 g, 0, 51 mmol) and 4-dimethylaminopyridi ne

(0.005 g, 0,042 mmol) were dissolved in methylene chloride (2 mL) and the resulting sol ution was cooled in an ice bath under nitrogen. Acetic anhydride (0,042 mL, 0,446 mmol) and triethylamine (0.062 mL, 0.446 mmol) were added via syringe with sti rring. After three hours, analysis by thin iayer chromatography ( 1 : 1 hexanes-ethyi acetate) indicated complete conversion. The reaction mixture was concentrated, loaded directly onto a flash silica gel col umn and eiuted with 4: 1 hexanes-ethyl acetate to give the title compound as a sticky orange solid (0,071 g, 89%) : Ή N MR (400 MHz, CDC ) δ 6.78 (td, J = 9.2, 2.2 Hz, 1 H), 6, 58 (td, J = 9, 1, 5.0 Hz, 1H), 3.63 (br s, 2H), 2,37 (s, 3H) ; ¹⁹ F NMR (376 MHz, CDCb) δ - 140.23 (d, J = 1 ,6 Hz), - 146, 77 (d, J = 1.9 Hz) ; EIMS m/z 187,

Example 72: Preparation of 5-amino-2-chloro-3-fluorobenzoic acid (C196)

To a solution of 2-chioro-3-fiuoro-5-nitrobenzoic acid (C206) (5 g, 22, 8 mmol) ethyl acetate ( 150 mL) was added 5% platinum on carbon (0, 5 g, 10% w/w) and the reaction mixture was stirred under hydrogen gas ( 15 psi) for 24 hours. The reaction mixture was carefully filtered through a pad of Ceiite ^® , the pad washed with 50% ethyl acetate In methanol, and the filtrate concentrated under reduced pressure. The crude product was triturated with diethyl ether to afford the title compound as a pale yellow solid (2, 1 g, 50%) : mp 187 - 189 °C; *H NMR (400 MHz, DMSO-de) δ 13.28 (br s, 1H), 6.81 (dd, J_≡_ 1,2, 2.4 Hz, 1H), 6.61 (dd, J_≡_ 2,4, 12.0 Hz, 1H), 5.77 (br s, 2H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -114,65; ESIMS m/z 190 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Exampie 72 :

5~Amino~2~chloro~3~(triffuoromethy!)benTOic acid (C197)

Isolated as a brown solid (3,2 g, 68%) : mp 195 - 197 °C; ^l NMR (400 MHz, DMSO-dg) δ 7.18 - 7.08 (m, 1H), 7.06 - 7,02 (m, 1H); ¹⁹ F NMR (376 MHz, DMSO-de) δ 61.21; ESIMS m/z 240 ([M + H] ⁺ ).

5-Amino~2~chSoro-3~methvlbenzoic acid (C198)

Isolated as a brown solid (3,2 g, 72%) : mp 190 - 192 °C; ^X H NMR (400 MHz, DMSO-de) δ 12.82 (br s, 1H), 6,76 (d, J = 2.4 Hz, 1H), 6.67 (d, J = 2.4, 1H), 2.22 (s, 3H); ESIMS m/z 186 ([M+H] ⁺ ).

5~Aniino~2 _f 3~difiuorobenzoic acid (C199)

Isolated as a brown solid (2,5 g, 60%) : mp 211 - 213 °C; H NMR (400 MHz,

DMSO-£fc) δ 13,20 (br s, 1H), 6.84 - 6.78 (m, 1H), 6,74 - 6.64 (m, 1H), 5.46 (br s, 2H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -138,22, -155,42; ESIMS m/z 174 ([M + H] ⁺ ).

5-Amino~3~chioro~2~ffuoroben¾oic acid (C200)

Isolated as a brown solid (4,0 g, 66%): mp 205 - 207 °C; H NMR (300 Hz, DMSO-cfc) δ 13,40 (br s, IN), 7.02 - 6,94 (m, 1H), 6,92 - 6.84 (m, 1H), 5.48 (br s, 2H); ¹⁹ F NMR (376 MHz, DMSG- e) δ -132,31; ESIMS m/z 190 ([M + H] ⁺ ).

5-Amino~2~ffuoro~3™methy!ben¾)ic acid (C201)

Isolated as a brown solid (5.2 g, 76%): mp 206 - 208 °C; ^X H NMR (300 MHz, DMSO-cfc) δ 12.82 (br s, 1H), 6,88 - 6.80 (m, 1H), 6.68 - 6.58 (m, 1H), 5.28 (br s, 2H), 2.12 (s, 3H); ¹⁹ F NMR (282 MHz, DMSO-/e) δ -132.24; ESIMS m/z 170 ([M + H] ⁺ ),

5~Arnino~3~chloro~2~m8thySbenzoic acid (C202)

Isolated as an off-white solid (1.3 g, 65%): mp 192 - 194 °C; H NMR (400 MHz, DMSO-de) δ 12.82 (br s, 1H), 6,93 (d, J = 2.1 Hz, 1H), 6.78 (d, J = 2.4 Hz, 1H), 5.37 (br s, 2H), 2,31 (s, 3H); ESIMS /z 186 ([M+H] ⁺ ).

S-Arii!no-3-fiuoro-2-methyibenTOic acid (C203)

Isolated as a brown solid (0.3 g, 55%); mp 164 - 166 °C; ^j H NMR (400 MHz, DMSO-de) δ 12.82 (br s, 1H), 6,87 (d, J = 2.0 Hz, 1H), 6.48 (dd, J = 2.0, 8.0 Hz, 1H), 5.36 (br s, 2H), 2.19 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-cfc) δ -116.94; ESIMS m/z 170 ([M÷H] ⁺ ),

5~Amino~3~chioro-2~metho3cybenz:oic acid (C204)

Isolated as a brown solid (2,5 g, 75%) : mp 173 - 175 °C; H NMR (400 Hz, DMSO-cfc) δ 12,8 (br s, 1H), 6.84 (d, J - 2.8 Hz, 1H), 6.79 (d, J - 2.8 Hz, 1H), 5.62 (br s, 2H), 3.68 (s, 3H); ESIMS m/z 202 ([M + H] ⁺ ).

5-Amino™3~fluoro~2-methQxyb

Isolated as a pale yellow solid (6.01 g, 85%) ; mp 148 - 150 °C; *H NMR (400 MHz, DMSO-cfe) δ 12.82 (br s, 1H), 6.72 - 6.66 (m, 1H), 6.55 (dd, J - 2.0, 13.6 Hz, 1H), 5.40 (br s, 2H), 3.69 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -131.02; ESIMS m/z 186 ([Μ + ΗΓ).

Example 73: Preparation of 2-chSoro-3-fSuoro-5-nitrobenzoic acid (C206)

To a suspension of 2~chioro-3-fluorobenzoic acid (10 g, 57.5 mmoi) in concentrated sulfuric acid (62 mL, 1149,5 mmol) was added concentrated nitric acid (4 mL, 86,2 mmol) dropwlse at -10 °C and the reaction mixture was stirred between -10 °C and 0 °C for 3 hours. The reaction mixture was slowly poured into a beaker of crushed ice (~ 1L), and the resulting precipitated solid was filtered and washed with water (100 mL). The crude product was recrystailized from hot water to afford the title compound as an off-white solid (7.5 g, 60%) : mp 163 - 165 °C; ^J H NMR (400 MHz, DMSO-c e) δ 14.60 - 13.92 (br s, 1H), 8.53 (dd, J = 2.8, 8.8 Hz, 1H), 8.44 - 8.41 (m, 1H); ⁱ⁹ F NMR (376 MHz, DMSQ- e) δ -108.50; ESIMS m/z 218 ([M-H] ^" ).

The following compounds were prepared in like manner to the procedure outlined in Example 73 :

benzoic

The title compound was recrystai iized from hot water to give a brown solid (9 g, 80%) : mp 165 - 167 °C; *H NMR (400 MHz, DMSO-c/g) δ 8,77 (d, J = 2.8 Hz, 1H), 8.61 (d, J = 2.8 Hz, 1H) ; ⁱ⁹ F N MR (376 MHz, DMSO-ds) δ -61.72; ESIMS m/z 268 ([M-H] ^" ). 2-ChSoro-3-methvhS-nstrobenzoic ac d (C20S)

The title compound was precipitated from a diethyl ether solution with n~pentane to give an off-white soiid (8,2 g, 65%) : mp 205 - 207 °C; *H NMR (300 MHz, DMSO-de) δ 8.41 (d, J = 2.4 Hz, 1H), 8.34 (d, J = 3,0 Hz, 1H), 2,24 (s, 3H) ; ESIMS m/z 214 ( [M-

2 _f 3~Dsffuoro-5~nitroben.5:osc acid (C209)

The title compound was recrystai iized from hot water to give an off-white soiid (5.2 g, 40%) : mp 132 - 134 °C; ^J H NMR (300 MHz, DMSO-de) δ 14.60 - 13.80 (br s, 1H), 8.74 - 8.62 (m, 1H), 8.52 - 8.40 (m, 1 H) ; ¹⁹ F NMR (282 M Hz, DMSO-de) δ - 125,36, - 132, 16; ESIMS m/z 202 ([M-H] ^' ) ,

3-Ch!oro-2-f!uoro-5-nitrobenzoic acid (C210)

The title compound was recrystaiiized from hot water to give an off-white solid (6.9 g, 55%) : mp 186 - 188 °C; ^X H NMR (400 MHz, DMSO-ds) δ 14.40 - 13.80 (br s, 1H), 8.78 - 8,70 (m, 1H), 8.58 - 8.48 (m, 1H); ³⁹ F NMR (376 MHz, DMSO- s) δ - 102.78; ES!MS m/z 218 ([M-H] ^" ).

2-F uoro-3-methvl-S-nitrobenEO!c acid (C211)

The title compound was precipitated from a methanol solution with water to give a pale brown solid (7.5 g, 58%): mp 168 - 170 °C; *H NMR (300 MHz, DMSO-cfe) δ 13.88 (br s, 1H) 8,48 - 8.40 (m, 2H), 2.41 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ - 106.64; ESIMS m/z 198 ([M-H] ^" ),

3~Chloro~2~m8thoxy~5~nitrobenzoic acid (C212)

Note: The reaction solvent used was a mixture of sulfuric acid and acetic acid (1:1), and the title compound was recrystai!ized from hot water and isolated as an off- white solid (9.3 g, 75%); mp 155 - 157 °C; ^j H NMR (300 MHz, DMSO-cfe) δ 8.54 (d, J 2.4 Hz, 1H), 8.42 (d, J = 2,4 Hz, 1H), 3,96 (s, 3H); ESIMS m/z 232 ([M-H] ^" ).

3-Fluoro-2-methoxy-5-nitrobenz:o!C acid (C2I3)

Note: The reaction solvent used was a mixture of sulfuric acid and acetic acid (1:1), and the title compound was recrystaliized from hot water and isoiated as an off- white solid (9.1 g, 70%): mp 106 - 108 °C; ^ν β NMR (400 MHz, DMSO-cfc) δ 13.62 (br s, 1H), 8.40 (dd, J - 2.8, 10.8 Hz, 1H), 8.32 - 8.28 (m, 1H), 4,04 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-ds) δ -125.26; ESIMS m/z 216 ([M + H] ⁺ ).

Example 74; Preparation of methyl! 3-chSoro-2-methyh5-nstrobenzoate (C2I4)

Step 1: Preparation of 3-chloro-2-methyh5-nstroben2:oic add. To a suspension of 3-chloro-2-methylbenzoic acid (10 g, 57.5 mmo!) in concentrated sulfuric acid (48 mL, 867 mmoi) was added concentrated nitric acid (2.5 mL, 68.4 mmoi) dropwise at -10 ^C C and the reaction mixture was stirred between -10 °C and 0 °C for 3 hours. The reaction mixture was slowly poured into a beaker of crushed ice (~ 1L), and the precipitated solid was collected by filtration and washed with water (100 mL), The crude product was recrystallized from hot water to give a mixture of 3-chloro-2-methyl- 5/6-nitrobenzoic acid as a brown solid (7.5 g), which was used without any purification: ESIMS m/z 214 ([M-H] ^" ).

Step 2: Preparation of methyl 3-chforo~2~methyS~5~nitrobenzoate. To a stirred solution of 3-chloro-2-methyl-5/6-nitrobenzoic acid (6 g, 28 mmoi) in methanol (100 mL) was added thionyi chloride at ambient temperature, and the reaction mixture was stirred at 80 °C for 4 hours. The reaction mixture was concentrated under reduced pressure. Purification by silica gel column chromatography using 20-30% ethyl acetate in petroleum ether as e!uent gave the title compound (1.5 g; 12% yield over two steps) as a pale-yellow solid: *H NMR (400 MHz, CDCI ₃ ) δ 8.58 (d, J - 2.4 Hz, 1H), 8.37 (d, J - 2.4 Hz, 1H), 3.97 (s, 3H), 2,72 (s, 3H); ESIMS m/z 228 ([M-H] ^" ),

The following compounds were prepared in iike manner to the procedure outlined in Example 74 :

Methyl S-fiuoro-l-methyl-S-nitrobenzoate (C2I5)

Isolated as a pale-yellow solid (1 g, 10% yield over two steps): ^l H NMR (300 MHz, CDCh) δ 8.58 (s, 1H), 8.04 (dd, J = 2.4, 9.0 Hz, 1H), 3.97 (s, 3H), 2,61 (d, J 2.4, 3H); ESIMS m/z 214 ([M + H] ⁺ ).

Example 75: Preparation of S-chioro-Z-methyl-S-nitrobenzoic acid (C216)

To a stirred solution of methyl 3-chloro-2-methyl-5-nitrobenzoate (C214) ( 1 , 5 g, 6.5 mmol) in a mixture of tetrahydrofuran, methanol, and water (2 : 1 : 2; 20 mL total) was added lithium hydroxide-monohydrate (0.820 g, 19.5 mmol), and the reaction mixture was stirred at ambient temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in water (20 mL) and acidified with 2 N hydrochloric acid ( 10 mL; pH = 1-2) , The resulting precipitated sol id was collected by filtration, washed with water (50 mL), and dried under vacuum to afford the title compound ( 1 g, 71%) as an off-white solid : mp 176 - 178 °C; *H NMR (300 MHz, DMSO-c e) δ 13.9 (br s, 1H), 8.43 (s, 2H), 2.64 (s, 3H) ; ESIMS m/z 214 ([M-

The following compounds were prepared in like manner to the procedure outlined

3- uorG-2-methy!-5-n!troben£G!C acid

Isolated as an off-white solid (0.800 g, 86%) : mp 146 - 148 °C; NMR (300 MHz, DMSO-cfc) δ 13,92 (br s, 1H), 8.37 (s, 1H), 8,25 (dd, J = 2.4, 9, 3 Hz, 1H), 2, 50 (d, J = 2, 1 Hz, 1 H) ; ¹⁹ F N MR (376 MHz, DMSG-de) δ - 110.64; ESIMS m/z 198 ([ -H] ^" ). Example 76; Preparation of Z-ch!ora-N^- imet

phenySbenzohydrazide (C

To a solution of 2-chloro-/V'-methyl-5-nitro-/V'-phenylbenzohydrazide (€219) (0.273 g, 0.893 mmol) in W,W-dimethylformamide (8.5 mL) cooled to 0°C \ .S added sodium hydride (60% oil immersion, 0.045 g, 1.116 mmol) . The reaction mixture was allowed to stir at 0 °C for 15 minutes and then methyl iodide (0.070 mL, 1.116 mmol) was added. The reaction mixture was allowed to warm to room temperature and was sti rred for 3 hours. The reaction was quenched with water ( 10 mL) and extracted with ethyl acetate (25 mL). The organic layer was washed with water (3 x 15 mL) and bri ne (15 mL) and then concentrated under reduced pressure to afford the title compound as a yellow solid (0.283 g, 98%) : *H NMR (400 MHz, CDCh) δ 8.13 (d, J = 2,6 Hz, 1H), 8,08 (dd, J = 8.8, 2.6 Hz, 1H), 7.53 (d, J = 8,8 Hz, 1 H), 7,32 (dd, J = 8.9, 7, 3 Hz, 2H), 6,95 (tt, J = 7,3, 1.1 Hz, 1 H), 6,75 (dt, J = 7.9, 1.1 Hz, 2H), 3.20 (s, 3H), 3.11 (s, 3H) ; IR (thi n film) 3074, 2925, 1662, 1524, 1494, 1345, 869, 741 cm ^"1 ; ESIMS m/z 320 ([M + H] ⁺ ) .

Example 77: Preparation of 2~chSoro-M'~methvhS~nitro~ ¥'~

phenylbenzohydrazide (C2

To a solution of 2-chioro-5-nitrobenzoic acid (0.300 g, 1.49 mmol) and 1-methyl- 1-phenyihydrazine (0,282 g, 2.31 mmol) in ethyl acetate (5.0 mL) stirred at room temperature were added pyridine (0.235 g, 2.98 mmol) and 2,4,6-tripropyl- l,3,5,2,4,6- trioxatriphosphinane 2,4,6-trioxide (T3P ^® ) as a 50% solution in ethyl acetate ( 1.421 g, 2.23 mmol) . The reaction mixture was stirred at room temperature for 48 hours. The reaction mixture was diluted with ethyl acetate (20 mL), The organic phase was washed with 1 M aqueous hydrochloric acid (15 mL), water ( 2 x 10 mL), and brine ( 10 mL) and was concentrated under reduced pressure. Purification by column chromatography using 0-35% ethyl acetate/hexanes as e!uent afforded the title compound as a pale yellow sol id (0,273 g, 60%) : ÷H NMR (400 MHz, CDC ) *H NMR (400 MHz, DMSO-de) δ 10.71 (s, IN), 8.47 (d, J - 2.8 Hz, 1H), 8.34 (dd, J - 8.8, 2.8 Hz, 1H), 7.89 (d, J - 8.8 Hz, 1H), 7.41 - 7, 17 (m, 2H), 6,94 (dt, J = 7,7, 1.0 Hz, 2H), 6.87 - 6.52 (m, 1H), 3.24 (s, 3H); IR (thin fil m) 3207, 3064, 2967, 2807, 1670, 1538, 1351, 737 cm ¹ ; ESIMS m/z 306 ([M + H] ⁺ ) ,

Example 78: Preparation of l-methy 2-(3,3,3-tnfluoropropy dene)hydraxine (C220)

To a solution of 3,3,3-trifl uoropropanal (0,600 g, 5.4 mmol) in ethanol (12 mL) was added methyl hydrazine (0.493 g, 10.8 mmol) and acetic acid (0. 1 mL) at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was poured into water (20 mL) and extracted with diethyl ether (2 x 20 mL) . The organic layer was dried over anhydrous sodi um sulfate, filtered, and concentrated under reduced pressure to afford the title compound (crude) as a brown liquid (0, 600 g) : *H NMR (300 MHz, CDCI3) δ 6.67 (t, 3 = 5.6 Hz, 1H), 5.34 - 5.30 (m, 1H), 3.10 - 2,96 (m, 2H), 2.83 (s, 3H).

Example 79: Preparation of 5-amino-W-(3-amsn 3-2 _i .4-difluorophenyS}-2- ch!orobenzamide hydrochloride (C221)

A 4 M solution of hydrochloric acid in 1,4-dioxane (4,5 mL, 18 mmoi) was added to a stirred solution of fert-butyl~A-((terf-butoxy)carbonyi)-A-(3-(5~amlno-2- chlorobenzamido)-2,6-difluorophenyl)carbamate (CI35) in dichioromethane (18 mL) at 23 °C. The resulting thick off-white mixture was stirred at 23 °C for 18 hours. The reaction mixture was concentrated by rotary evaporation to afford the title compound as an off-white powder (0.660 g, 99% crude yield): H NMR (400 MHz, DMSO-de) δ 10.16 (s, 1H), 7,47 (d, 3 = 8.5 Hz, 1H), 7.23 (br s, 1H), 7,17 (br d, J ^~ 8.5 Hz, 1H), 6.90 (td, 3 = 10, 1.2 Hz, 1H), 6.80 (m, 1H); ESIMS m/z 298 ([M + H]+).

Example 80: Preparation of 2-chSoro-/¥-{3-(2 _f 2-dsfSuoroacetamido}-2,4- difiuorophenyl}-5-nitrobenxamsde (C222)

To a solution of /V-(3-amino-2,6-difluorophenyl)-2,2-difluoroacetamide (C186)

(0.455 g, 2,05 mmol) in ethyl acetate (7 mL) was added sodium bicarbonate (0.344 g, 4.10 mmol) and 2-chioro-5-nitrobenzoyl chloride (0, 451 mg, 2,05 mmol). The reaction mixture was stirred for 3 hours at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water (15 mL). The organic layer was passed through a phase separator to dry and concentrated to afford the title compound as a white solid (0,55 g, 66%): Η NMR (400 MHz, DMSO-cfc) δ 10,80 (s, 1H), 10.69 (s, 1H), 8.50 (d, 3 - 2.7 Hz, 1H), 8.35 (dd, 3 = 8.8, 2,8 Hz, 1H), 7,94 - 7,80 (m, 2H), 7.31 (td, 3 = 9.3, 1,8 Hz, 1H), 6,55 (t, 3 = 53.2 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-cfc) δ -120,61 (d, 3 = 2.6 Hz), -124.72 (d, J = 2.7 Hz), -125,81; ESIMS m/z 406 ([M + H] ).

Example 81: Preparation of fert-butyl (3-methyi-4-nitrophenyl}carbamate

A _/ W-DimethyipyNdi n-4-amine (2,41 g, 19.72 mmol) was added portionwise to a sti rring sol ution of 3-methyi-4-nitroanillne ( 15 g, 99 mmol) and di-ferf- butyl dicarbonate (25,8 g, 118 mmol) in dlchioromethane (200 mL) . The resulting yellow solution was sti rred at 24 °C for 18 hours and concentrated under vacuum on a rotary evaporator. Purification by silica gel flash chromatography with a gradient of ethyl acetate in hexane to give the title compound as a pale yel low solid ( 11.5 g, 44%) . ^' Ή N MR (400 MHz, CDC ) δ 8.04 (d, J = 9.0 Hz, 1 H), 7.41 (d, J = 2,4 Hz, 1H), 7,30 (dd, J = 9.0, 2, 5 Hz, 1H), 6.80 (s, 1H), 2,62 (s, 3H), 1.53 (s, 9H) ; ⁱ³ C NMR (101 MHz, CDCB) δ 151 ,96, 142,97, 136.22, 126.70, 120,79, 115, 55, 81.75, 28.22, 21.45; ESIMS m/z 253

([M + H] ⁺ ) .

Example l Resolution of racemic trans-2, 2-dichloro-3-(3,5- dich!orophenyi)cyc!opropane- l-carboxyilc acid with (Z.)-leuci namide to provide { 1R,3R}~ 2, -dichloro-3-(3,5-dichlorophenyl)cyclopropane- l-carboxylic acid

A mixture of (L)-leucinamlde ( 163 mg, 1.25 mmol) and racemic trans-2,2- dichloro-3-(3,5-dich!orophenyl)cyc!opropane-carboxy!ic acid) (750 mg, 2.5 mmol) in acetonitrile (20 mL) was sti rred at 60 °C for 0.5 hours. After a sol id began to deposit, the mixture placed at room temperature for 4 hours. The white solid was collected, washed with mini mal acetonitrile and dried : *H NMR (400 MHz, DMSO-d ⁵ ) δ 7,81 (s, 1H), 7.53 (t, J = 1.9 Hz, 1 H), 7.43 (d, J = 1.9 Hz, 2H), 7,31 (s, 1H), 3.58 - 3.44 (m, 1 H), 3.27 (d, J = 8.6 Hz, 1 H), 3.08 (d, J = 8,6 Hz, 1H), 1 ,68 (dt, J = 13.3, 6,6 Hz, 1H), 1 ,49 (dt, J = 10.1, 6.8 Hz, 2H), 0.89 (t, J = 6,7 Hz, 6H) .

The white solid salt was diluted with EtOAc and washed with IN HCI and bri ne solution. The organic layer was dried over NazSC , filtered and concentrated to afford the title product as a white solid: (0.202 g, 91% ee, 27% yield); ^"! H NMR (300 MHz, CDC ) δ 7.36 (t, J = 1.9 Hz, 1H), 7,17 (dd, J = 1.9, 0.7 Hz, 2H), 3.48 - 3.37 (m, 1H), 2.87 (d, J = 8.3 Hz, 1H), ¹³ C NMR (400 MHz, DMSO-d ⁶ ) δ 166,28, 136,40, 133,39, 127.27, 127.04, 61,36, 37.10, 35.98. LCMS m/z = 298.9 [M + H].

Example 2 Resolution of racemic trans-2,2-dichloro-3-(3-chloro-4- fluorophenyl)cyclopropane-l-carboxylic acid with ( )-ieuclnamide to provide (R,R)-trans- 2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-l-carbo xylic acid

A mixture of (L)-leucinamlde (0,45 g, 3.5 rnmoi) and racemic frans-2,2-dichloro-

3-(3-chloro-4-fluorophenyl)cyclopropane-carboxylic acid) (1.41 g, 5 mmo!) in acetonitrile (20 mL) was stirred at 60 °C for 0,5 hours. After a solid began to deposit, the mixture was placed at room temperature for 4 hours. The white solid was collected, washed with minimal acetonitrile and dried: 1H NMR (400 MHz, DMSO-d6) δ 7.81 (s, 1H), 7.53 (t, J - 1.9 Hz, 1H), 7.43 (d, J = 1.9 Hz, 2H), 7.31 (s, 1H), 3.58 - 3.44 (m, 1H), 3.27 (d, J = 8.6 Hz, 1H), 3.08 (d, J = 8.6 Hz, 1H), 1.68 (dt, J = 13.3, 6,6 Hz, 1H), 1,49 (dt, J = 10,1, 6.8 Hz, 2H), 0.89 (t, J = 6.7 Hz, 6H),

The white solid salt was diluted with EtOAc and washed with IN HCi and brine solution. The organic Iayer was dried over a2S0 , filtered and concentrated to afford the title product as a white solid: (0.64 g, 91% ee, 45% yield); 1H NMR (400 MHz, DMSO- d6) δ 13,29 (s, 1H), 7,72 (dd, J - 7,1, 2.1 Hz, 1H), 7.56 - 7.32 (m, 2H), 3.46 (d, J = 1.0 Hz, 2H); 19F NMR (376 MHz, DMSO-d6) δ -117.35.

Example 3 Resolution of racemic trans-2, 2-dichloro-3-(3,4- dichlorophenyl)cyclopropane-l-carboxylic acid with (L)-leucinamide to provide (R,R)- trans-2,2-dichloro-3-(3,4-dichlorophenyl)cyclopropane-l-carb oxylic acid

A mixture of (L)~ieucinamide (326 mg, 2.5 mmoi) and race ic trans-2,2-dichloro- 3~(3,4-dichlorophenyl)cyclopropane-carbQxyiic acid) (1,5 g, 5 mmol) in acetonitrlie (20 ixiL) was stirred at 60 °C for 0,5 hours. After a solid began to deposit, the mixture was placed at room temperature for 4 hours. The solid was collected, washed with minimal acetonitrlie and dried: *Η INMR (400 MHz, DMSG-d ⁶ ) δ 7.72 (s, 1H), 7,64 (d, J = 2.1 Hz, 1H), 7,60 (d, 3 - 8.3 Hz, 1H), 7.34 (dd, J - 8.4, 2,1 Hz, 1H), 7,31 - 7,26 (m, 1H), 3.48 (dd, J - 8.2, 6.2 Hz, 1H), 3.26 (d, J - 8.6 Hz, 1H), 3.03 (cl, 3 - 8,7 Hz, 1H), 1,74 - 1,57 (m, 1H), 1.47 (ddd, 3 = 14,6, 7.7, 6,1 Hz, 2H), 0,89 (t, J = 6,9 Hz, 6H),

The white solid salt was diluted with EtOAc and washed with IN HC! and brine solution. The organic layer was dried over NazSQ.*, filtered and concentrated to afford the title product as a white solid: (0.56 g, 96% ee, 36% yield); ^J H NMR (500 MHz, DMSG-d ⁶ ) δ 13.39 (s, 1H), 7.76 (d, J = 2.1 Hz, 1H), 7.64 (d, J = 8,3 Hz, 1H), 7,44 (dd, J = 8.4, 2.1 Hz, 1H), 3.49 (s, 2H), ¹³ C NMR (126 MHz, DMSO) δ 166,34, 133.35, 130.47, 130.33, 130,09, 129,77, 128.81, 61.43, 37.00, 36,06, LCMS m/z - 298.9 [M + H].

E ample 4 Resolution of racemic tra7S-2,2-dichloro-3-(3-trifiuoromethyi~4- fluorophenyl)cyclopropane-l-carboxylic acid with (L)-!euclnamide to provide

-dichloro-3-(3-trifluoromethyl-4-fluorophenyl)cyclopropane-l -carboxylic acid

A mixture of (L)~ieucinamide ( 15.6 g _f 120 mmol) and racemic irans-2, 2-dichloro- 3-(3-trifl uoromethyl-4-fluorophenyl)cyclopropane- l-carboxylic acid (63.4 g, 200 mmoi) in acetonitriie (800 mL) was stirred at 60 °C for 1 hr. After a solid began to deposit, the mixture was placed at room temperature for 4 hours. The solid was col lected, washed with mi nimal acetonitriie and dried to afford the salt of (X)-!euc! namide and trans-

(jR _/ 3R)-2,2-dichlQrQ-3-(4-fluoro-3-(trlfl uoromethyi)phenyl)cyclopropane- l-carboxylate as a white solid : (38.9 g, 95% ee, 43%) ; *H N MR (400 MHz, D SO-d ⁶ ) δ 7.80 (s, IN), 7.73 (m, Hz, 2H), 7.49 (dd, J = 10.7, 8.6 Hz, 1 H), 7.31 (s, 1H), 3.53 (dd, J = 7,9, 6.4 Hz, 1 H), 3.34 (d, J = 8.6 Hz, 1H), 3.07 (d, J = 8.6 Hz, 1H), 1.77 - 1.60 (m, 1H), 1.60 - 1.40 (m, 2H), 0,89 (t, J = 6.7 Hz, 6H) ; ¹⁹ F N MR (376 MHz, DMSO) δ -59.88, - 117.93.

The white solid salt was dil uted with EtOAc and washed with 1.5N HO and water. The organic layer was dried over NazSCk, filtered and concentrated to afford the title product as a white solid (27,3 g, 95% ee, 43% yield) . ^X H NMR (400 M Hz, DMSO-d ⁶ ) δ 13.24 (s, 1H), 8.03 - 7.71 (m, 2H), 7.54 (dd, J - 10.6, 8.7 Hz, 1H), 3.65 - 3.51 (m, 2H); ⁱ⁹ F NMR (376 MHz, DMSO-cl ⁶ ) δ -59.93, - 117.06; LCMS m/z = 316 [M-H] .

E ample 5 Resolution of racemic frans-2,2-dichloro-3-(4-fluoro-3- (trifluoromethyl)phenyl)cyclopropane- l-carboxylic acid with ( ?)-2~amino~3- phenylpropanamide ((D)-phenylalanine) to provide (/?)-2-amino-3-phenylpropanamide -2,2-dichloro-3-(4-fluoro-3-(trifl uoromethyl)phenyl)cyclopropane- l-carboxylate

In a flask with a magnetic stirrer, a mixture of 2,2-dichioro-3-(4-fl uoro-3- (trifluoromethyl)phenyl)cyclopropane- l-carboxylic acid ( 1.58 g, 5, 0 mmoi) and (R)-2- amino-3-phenyl propanamide (411 mg, 2.5 mmol) in acetonitriie (20 mL) was heated to 60 °C. The resulting suspension was sti rred at 60 °C for 10 mln, then cooled to RT. The mixture was stirred overnight. The product was filtered and washed with acetonitriie, then dried in air and at 35 °C in a vacuum oven to give (R)-2-ami no-3~

phenyipropanamide (lj ,3 3)~2,2-dichioro~3-(4~fiuoro-3-

(trifluoromethyl)phenyl)cyclopropane- l-carboxylate (710 mg, 1,475 mmoi, 29.5 % yield) as a white solid. Chira! HPLC analysis i ndicated the ratio of SS/'RR was 6/93 (86% ee) . E ample 6 Resolution of racemic frans-2,2-dichloro-3-(4-fluoro-3- (trifluoromethyl)phenyl)cyclopropane- l-carboxylic acid with (S)-2~amlno-3- phenylpropanamide to provide (S)-2~amino-3~phenylpropanamide ( lS,3S)-2,2~dichloro- 3-(4-fluoro-3-(trifl uoromethyl)phenyl)cyclopropane- l-carboxylate

In a flask with a magnetic stirrer, a mixture of racemic 2,2-dichloro~3-(4-fluoro- 3-{trifluoromethyi)phenyl)cyciopropane-l-carboxylic acid ( 1.58 g, 5,0 mmol) and (S)-2- amino-3-phenyl propanamide (411 mg, 2, 5 mmol) in acetonitrile (ACN, 20 mL) was heated to 60 °C. The resulting suspension was sti rred at 60 °C for 10 mi n, then cooled to rt. The mixture was stirred overnight. The product was fi ltered and washed with ACN, then dried in air and at 35 °C in a vacuum oven to give (S)-2-amino-3- phenylpropanamlde (lS,3S)-2,2-dichloro-3-(4-fluoro-3-

(trifluoromethyl)phenyl)cyclopropane- l-carboxylate (0,669 g, 1.390 mmol, 27, 8 % yield) as a white solid. The chiral HPLC i ndicated the ratio of SS/RR was 96/3 (93 %ee) .

The following compounds were prepared In like manner to the procedure outlined in Example 1 :

frans-S-{3-(3- romo-4-chSor jphenvl)-2 _f 2-dsch orocvclopr ipane-l- carboxamsdo)-2-chloro~Af-{2,4~difluoro~3~(2 _J ,2 _f 2~

trifluoroacetamido)phenyl)benzamide (F 1358)

Isolated as a white sol id (0.140 g, 63%) .

frai s~5~{3~{3~Bromo~4~chSorophen¾fl)-2 _J ,2-dschforocyc!opropane~l~

carboxamsdo}-2~chloro~/¥~(3~(2,2~diffuoroacetamido)~2 _f 4~

dif!uoropheny!}benza iide (F 1359)

Isolated as a white solid (0,098 g, 56%).

frans~2~Chforo~/^~(4~chforo~3-(2,2 _? 2-triffuoroacetami€lo}phenyl)~5~{2 _J ,2~ dichforo~3~{3~chloro~4~ffuorophenyf }cycSopropane-l~carboxamido}ben.iam!de (F1366)

Isolated as a white soiid (0,076 g, 80%).

frans-2-Chloro-S-(2 _? 2-d!chlo!O-3-{3-ch!oro-4-fluoropheny!)cvcSopropane-I- carboxamsdo)-M-(3 _f S-d!chSoro-4-{2 _? 2,2-trsfluoroacetam!do)phenyS)benz:amide (F1388)

Isolated as a white solid (0.069 g, 76%).

trans~2~Chforo~M~(3~chforo-4~(2 _f 2 _f 2~triffuoroacetamido)phenvf )~5~(2 _f 2~ dichioro-3-(3-chSoro-4-fiuoropheny )cyc!opropane-I-carboxamido)benxamide (F1384)

Isolated as a white solid (0,093 g, 70%). fraiis~2~Chforo~M~(3~cyano~4-(2 _f 2,2-triffuoroacetamido}phenyl)~S~(2,2~ dichforo~3~(3~chloro~4~ffuorophenyf )cycSopropane-l-carbo amido}b8nramide

(FI388)

Isolated as a yellow foam (0.039 g, 72%),

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3-

(triffuoromethy!)phenyf }cycSopropane-l~carboxamido}~ ~(2 _f 3~dimethyl~4- (2,2 _f 2-trifiuoroacetam!do)pheny!)benxamide (F1392)

Isolated as a white foam (0.055 g, 80%) ,

f ^, ra«s-2-Ch oro-5-(2,2-d!ch!oro-3-{3-chtoro-4-f!uoropheny!}cycSopropane- I- carboxamsdo)-W-(4-(2 _f 2 _? 2-tr!flu iroaceta!T!ido)-3- (triffuoromethyS)phenyl)ben-iamide (F1393)

Isolated as a white foam (0.078 g, 75%) .

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(3-(2 _f 2- dif uoroacetamsdo)-2 _i ,6-dsfSuoropheny!)benza!Ti!de (F1394)

Isolated as a white foam (0.078 g, 75%).

2-€ΗΙθΓθ-5-(( 1^,3^)-2,2-€ίεΗ§θΓθ-3-(4-ΑυοΓθ-3-

(triffuoromethy!)phenvf )cycSopropane~l~carboxamido)~M~(2~methyf~3~(2 _J ,2 _f 2~ trifluoroacetamido)phenyl)benzamide (F1451)

Isolated as a white so!id (0.087 g, 75%).

5~({J^3 ?)-2 _? 2~Dich!oro~3~(3 _? 4-dichforopheny!)cycfopropane~l~carboxamsdo)" i¥-(3~(2,2~difluoroacetamido)~2 _f 4~dif uorophenyS)~2~fluorobenzaniide (F1491)

Isolated as a white so!id (0.086 g, 76%).

5~({J^3 ?)-2 _? 2~Dich!oro~3~(3 _? 4-dichforopheny!)cycfopropane~l~carboxamsdo)" i¥-(2 _f 4~difluoro~3~(2,2 _f 2~tnfSuoroacetaniido)pheny!)~2-fSuorob8ra:am!de (F1492)

Isolated as a white so!id (0.102 g, 87%).

5~({J^3 ?)-2 _? 2~Dich!oro~3~(3 _? 4-dichforopheny!)cycfopropane~l~carboxamsdo)" i¥-(5~(2,2~difluoroacetamido)~2 _f 4~dif uorophenyS)~2~fluorobenzaniide (F1509)

Isolated as a white foam (0.059 g, 51.9%).

5-{(II?,JI?)~2 _f 2~DichSoro~3-(3 _f 4~dichforophenyS)cyclopropane-l~carbo3 amido}~ W-{2,4-dif!uoro-5-(2j2,2-tnf!uoroacetamido)phenyS)-2-f!uorob en¾ar!iide (FI5I0)

Isolated as a tan solid (0.119 g, 85%).

fraiis~S~(3-(4~Bromophenvf }-2,2~dichSorocyc opropane~l~carboxamsdo)-2- ch!oro-J¥-(3- -dif!uoroacetamido)-2 _f 4-dif!uorophenyS}benzamide (FI597)

Isolated as a clear, colorless oil (0,050 g, 86%),

frans-2-Ch!oro-5-(2,2-dichSoro-3-(4-f!uoropheny!)cycSopro pane-l- carboxamsdo)-M-(3-(2 _? 2-difluoroacetamido)-2 _f 4-difluor iphenyl)ben2:arnide (F1598)

Isolated as a clear, colorless oil (0.052 g, 78%),

frans-2-Chloro-S-(2 _? 2-d!chloro-3-(4-ch!orophenvS}cyclopropane-i- carboxamsdo)-W~(3-(2,2~difluoroacetamido)~2 _? 4-dif!uorophenyl)benzamide (F1599)

Isolated as a white foam (0.101 g, 87%).

frans~5~{3~{3~Bromophenyl)~2 _f 2~dich!orocycfopropane-l~carbo5 amido}~2~ chSoro-i¥~(3-(2 _f 2-d!fluoroacetamido)-2,4~diff uorophenyl)ben2amide (F1600)

Isolated as a clear, colorless oil (0.057 g, 80%),

frans-2-Choro-5-(2 _f 2-d!chSoro-3-(3-chSorophenvl)cycopropane-I- carbo5amido)~i¥-(3~(2 _f 2~diffuoroacetarnido}~2 _f 4~difSuorophenyS)ben.iam!de (F1601)

Isolated as a white foam (0.076 g, 75%).

frans~2~Chforo~5~(2 _f 2~dichSoro-3~(3~ffuorophenyf)cycSopropane-l~ carbo¾amido)~i¥~(3~(2 _f 2~d!fuoroacetamid>}~2 _f 4~difSuorophenyS)b8n :am!de (F1602)

Isolated as a white foam (0.103 g, 83%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cyclopropane~l~ carbo3amido)~i¥-(2 _f 4~difluoro~3~(2 _f 2 _f 2~tnfluoro~i¥- riiethy!acetamsdo)pheny}benzamide (FI6I4)

Isolated as a white foam (0.109 g, 93%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cyclopropane~l~ carboMamsdo)-i¥-(2 _f 4-d!fiuoro-3-(2,2 _i .3,3 _/ 3-pentafSuoro-/¥- riiethy!propanamido)phenyS}benzamide (F16I5)

Isolated as a white foam (0.061 g, 68%). The title compound was prepared from /V-(3-arnino-2,4-difluorophenyl)-5-(3-(3-bromo-4,5-dic lorophenyl)-2,2- dichlorocyclopropane-l-carboxamido)-2-c lorobenzamide which was prepared via methods described in U.S. Patent Application Publication US20160304522A1 (F621). frans-2-Chloro-S-(2 _? 2-d!chlo!O-3-(4-f!uoro-3-iodophen¾f cv'clopropane-i- carboxamsdo)"W~(3-(2,2~diffuoroacetamido)~2 _? 4-dif!uorophenyl)benzamide (F1624)

Isolated as a white solid (0.066 g, 74%).

2-Chloro-5-((I^3^)-2 _f 2-dschSoro-3-(4-ch oro-3-

(triffuoromethy!)phenvf )cycSopropane~l~carboxamido)~M~(2 _f 4~diff uoro~3~ (2 _f 2 _f 2~trifluoroacetamido)phenyl)benzamide (F1656)

Isolated as a white foam (0.077 g, 84%).

2~Chloro~5~{(J ? _jr 3 ?)-2 _i 2~dschSoro~3~i4~chforo~3~

(triffuoromethy!)phenvf )cycSopropane~l~carboxamido)~M~(3~(2 _? 2- diff uoroacetamido)~2 _f 4~difSuorophenyl)ben¾amide (F16S7)

Isolated as a white foam (0.082 g, 91%).

hSoro-5-{(Ii? _f 3i?)-2,2-dsch!oro-3-(3-(trsfSuoromethv ^, !)pheny }c¾ ^r cSopropane- 3rboxarnido}~Af~{3~{2 _J ,2~dsf!uoroacetamido)~2 _f 4~d!ffuorophen^

(F1875)

Isolated as a white solid (0.077 g, 86%).

-ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

uorom8thyS}phenyl)cvc!opropan8~l-carbo3amido)~¥~(5~(2 _f 2~

diffuoroac8tamsdo}-2,4~dsfluoro~3-methy!phenyS)benz:amsde (F1680]

Isolated as a white foam (0.048 g, 71%).

2-ChSoro-5-((I ? _J ,J?}-2j2-dschtoro-3-(3-ch oro-4-fluorophenv!}cv'c!opropan carboxamsdo)-M-(2 _f 4-d!fiuoro-3-(2 _? 2 _f 2-trif!uoroaceta!Ti!do)phenyS}ben¾a (F1695)

Isolated as a yellow foam (0.094 g, 80%).

2-ChSoro-5-((I ? _J ,J?}-2 _f 2-dschtoro-3-(3-choro-4

carboxamsdo)-i¥-(2 _f 4-d!fiuoro-3-(2 _? 2 _i .3 _f 3 _i 3- pentafuoropropana idQ)phenyl)ben;zarn!de (FI

Isolated as a white foam (0.089 g, 71%).

2-€ΗΙθΓθ-5-{(Ιί?,3ί?)-2,2-«^ίεΗ!θΓθ-3-(3 -ίΙυο!Ό-5- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(3~ (2 _f 2~ diffuoroacetamsdo)-2 _J ,4~dsf!uorophenyf)benzamide (F1711)

Isolated as a white solid (0,075 g, 84%).

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethy!)phenv ^, !)cycSopropane-l-carboxam!do)-W-(S-(2 _f 2- dif uoroacetamsdo)-2 _i ,3 _? 4-trsfluoropheny!}ben2:a!T!!de (F1744)

Isolated as a clear, colorless oil (0.117 g, 99%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cyclopropane-i- carboxamsdo)-W-(2,4-d!f!uoro-3-(2 _f 2 _? 2-trif!uoroaceta!T!!do)phenyl)-i¥- methyfbenzamsde (F1792)

Isolated as a white foam (0.082 g, 70%),

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(4-fSuoro-3-

(tnflujromethyS}pheny!)cyc!opropane-I-carboxamido)- f-f2 _? 4-difluoro-3- (2,2,2~triffuoroacetarnido)phenyS}~i¥-methyfben-5:amsde (F1795)

Isolated as a light yellow oil (0.091 g, 79%).

f ^, ra«s-5-(3-C3,5-6/s(Trif!uoromethy )pheny!}-2,2-dsch!orocvc!opropane-l- ε3^οχ3!Τϊ^ο)-2-εΗΙθΓθ-ί¥-(2,4-€!ί1υοΓθ- 3-{2,,2 _? 2- tr!f!uoroacetamido)phenyS}ben¾amsde (FlSOi)

Isolated as a white solid (0.098 g, 86%).

f ^, ra«s-5-(3-(3,5-6/s(Trif!uoromethyt)pheny!}-2,2-dsch!o rocyc!opropane-l- ca hoxamldo i-chloro-N-iS-il _/ l-difluomBcetamido)-!^- difiuoropheny^benzamide (FI802)

Isolated as a white solid (0.096 g, 86%).

The following compounds were prepared in like manner to the procedure outlined in Example 2:

M-(3-Acetamsdo-2 _f 4-difluorophenyS)-5-((I^3^}-2 _f 2-d!chSoro-3-C3 _i 4- dichforopheny!)cycfopropane~l~carboxamido)~2~fluoroben_iam!d e (F1493)

Isolated as a tan solid (0.100 g, 66%). ~(5-Acetamsdo~2 _f 4~difSuorophenyS)~5~((J^3^)~2,2~dichSoro-3~{3 _f 4~ dichforopheny!)cycfopropane~l~carboxamido)~2-fluorobera:am!d e (F15

Isolated as a white foam (0.108 g, 84%).

W~(3-Acetamsdo~2 _f 4~difSuorophenyS)~2~chSoro-5~{{JI?,3i?)~2 _f 2~dichforo~3~(4~ chloro~3~{triffuoromethyf )phenvl)cyc opropane~l~carboxamido)benzamide (F1658)

Isolated as a white solid (0.061 g, 72%).

~(3-Acetamsdo~2 _f 4~difSuorophenyS)~2~chSoro-5-{(JI?,3l?)~2 _f 2~dichforo~3~{3~ ch!oro-4-f!uorophenyS)cvciopropane-l-carboxamido)ben2:amsde (FI694)

Isolated as a white foam (0.094 g, 88%). The title compound was prepared from A -(3-amino-2 _f 4~difluorophenyi)-2-chloro~5-(( l ?,3/?)~2,2-dichloro~3-(3-chioro~4- fluorophenyl)cyclopropane-l-carboxamido)benzamide which was prepared using methods described in U.S. Patent Application Publication US20160304522A1 (F317). W-(3-Acetamsd j-2 _f 4-difluorophenyS}-2-chSoro-5-(CI ?,3 ?}-2 _f 2-dsch oro-3-(4- f uoro-3-(tnfluoromethyS)phen¾f cv'clopr ipane-i-carboxa!T!!do)-/¥- methylbenzamsde (F1799)

Isolated as a white foam (0.070 g, 65%).

frans-W-(3-Acetam!do-2,4-dif!uorophen¾f -S-(3-(3 _? 5-

Ms(triffuoromethy!)phenyl)-2 _J ,2~dschforocycfopropane~l~carboxamido)-2~ chSorobenzamide (F1803)

Isolated as a white foam (0.062 g, 58%).

The following compounds were prepared in like manner to the procedure outlined in Example 3:

2~£Η1θΓθ-5~{(1ί?,,3ί?)~2,2~€ϊεΗ!θΓθ~3~(3,5~� �ϋεΗ1θΓο Η6πν!)ενε!ο Γο 3Π6~1~ carbo5 am ido)~i¥-(2,6~difluoro~3~(2 _f 2 _f 2~trifluoroacetamido)phenyl)-3~ fluorobenza ide (F1340)

Isolated as a white so!id (0.050 g, 96%).

2~Chloro~5~((l ? _f 3 ?)-2 _J ,2~dschSoro~3~(3 _f 5~dichlorophenyf }cycSopropane~l~ carboxamsdo)-i¥~(3-(2 _f 2-diffuoroacetamido)~2,6-dif!uorophenvl}-3~

f uorobenzamide (F1341)

Isolated as a yellow solid (0,052 g, 100%).

2~ChSoro-5~{(li? _J ,3i?)~2 _f 2~dich!oro~3~(3,4 _J ,S~trichlorophenyf )cyclopropane-l~ carbo3 amido)~i¥-(2 _f 6~difluoro~3~(2 _f 2 _f 2~tnfluoroacetamido)phenvl)-3- fluoroberwa ide (F1342)

Isolated as a white solid (0,051 g, 98%),

2-Chloro-5-((l^,3^)-2 _f 2-cschSoro-3-(3 _f 4 _i ,5-trich!oropheny cvcioprop« amsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenvl)-3~ ff amide (F1343)

Isolated as an off-white solid (0.050 g, 99%).

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cvclopropane carboxamsdo)-W-(2 _? 6-d!f!uoro-3-(2 _f 2 _i 2-trif!uoroaceta!T!!do)phenvl)-3- ffuorobeniarnide (F1344)

Isolated as a white solid (0,049 g, 100%).

-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvcI fuorobenzamide (FI345)

Isolated as a white solid (0,047 g, 99%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethvOphenyi}cvcfopropane-l-carboxamido}-/y-(2,6-dif uoro-3- (2,2,2-trif!uoroacetamido)phenyS)-3-f!uorobenzar!i!de (F1346)

Isolated as a white solid (0.046 g, 99%).

2~Chloro~5~((l ? _f 3 ?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf )cycSopropane~l~carboxamido)~M~(3~(2 _? 2- diff uoroacetamido)~2 _f 6~difSuorophenyl)~3~fSuorobenzamid8 (F1347)

Isolated as an off white solid (0.045 g, 100%),

J¥-(3-(2-Brom j-2 _i .2-difSuoroacetamsdo}-2j6-difSuoropheny }-2-ch 3ro-5- ((ii? _f 3^)-2 _? 2-dichloro-3-{4-fSuoro-3-(trif!uoromethyl)phenyl)cyc oprop« carboxamsdo)-3-fi uoroben2:a!T!!de (FI3S6)

Isolated as an off white solid (0.048 g, 96%).

2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenyl)cyc opropane~l~ carboxamido)~i¥~(S~(2 _f 2~d!f uoroacetamido}~2 _f 4~difSuorophenyS)~3~

f uorobenzamide (FI400)

Isolated as a tan solid (0.086 g, 90%).

2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenvl)cyc opropane~l~ carbo3 amsdo)-i¥-(2,4-d!fiuoro-5-(2,2 _i .2-tnfiuoroacetam!do)phenv!}-3-

Isolated as a white solid (0.087 g, 89%).

loro~5~((l ? _f 3 ?)-2 _i 2~dschSoro~3~i3 _f 4~dich!orophenyf }cycS

iamsdo)-i¥~(5-(2,2~diffuoroacetamido)~2 _? 4-dif!uoropheny

f uorobenzamide (F1402)

Isolated as a tan solid (0.078 g, 83%).

fOc d

carboxamsdo)-W-(2 _? 4-d!f!uoro-5-(2 _f 2 _i 2-trif!uoroaceta!T!!do)phenyl)-3 fiuorobenzamide (FI403)

Isolated as a light-tan solid (0.090 g _f 93%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf )cyclopropane-l- carbo3 amido)~i¥~(S~(2 _f 2~d!f uoroacetamido}~2 _f 4~difSuorophenyS)~3~ f uorobenzamide (FI404)

Isolated as a !ight-tan solid (0.085 g, 91%).

2~ChSoro-5~{(li? _J ,3i?)~2 _f 2~dich!oro~3~(3,4 _J ,S~trichlorophenyf )cyclopropane-l~ carbo5 amido)~i¥-(2,4~difluoro~5~(2 _f 2 _f 2~trifluoroacetamido)phenyl)-3~ ffuorobenzamide (F140S)

Isolated as a white solid (0.085 g, 88%).

2-Ch!oro-S-((l^,3^)-2,2-dschSoro-3-(4-f!uoro-3- (tnfluoromethyS}pheny!)cyc!opropane-I-carboxamido)- f-(S-(2 _i 2- difluoroacetamsdo)-2 _f 4-dsfluoropheny!)-3-fluorobenEamide (F1406)

Isolated as a light-tan solid (0.087 g, 94%).

2-ChSoro-5-((ll?,3 l)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3 amido)~ ¥~(2,4~diff uoro-5~ (2,2,2-trif!uoroacetamido)phenyS)-3-f!uorobenzar!i!de (F1407)

Isolated as a white solid (0.086 g, 89%).

Soro-5~((U?,3H)~2 _f 2~dich!oro~3~{3,5~dichforophenyf)cvcloprop«

Isolated as a light-tan solid (0.084 g, 88%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 5~dich!orophenyf)cycS carboxamsd 3}-W-(2,4-dif!u3ro-5-(2,2,2-trif!uoroacetamido)ph eny! Huorobenzamide (F1409)

Isolated as a white solid (0.087 g, 89%).

2~Chloro~5~((l ? _f 3l?)-2 _i 2~dschSoro~3~i3 _f 4~dich!oroph l)cycl carboxamsdo)-i¥~(3-(2 _f 2-diffuoroacetamido)~2,6-di

methy!benzamide (F1429)

Isolated as a white solid (0,056 g, 99%).

2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo3amsdo)-i¥-(2,6-d!fiuoro-3-(2,2 _i .2-tnfiuoroacetam!do)phenv!}-3- methv!benzamsde (F1430)

Isolated as a tan solid (0.057 g, 98%).

2~Chloro~5~((l ? _f 3?)-2 _i 2~dschSoro~3~i3 _f 4 _f 5~trichforophenyf)cycfopropane~l~ carboxamsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenyl)-3~ methy!benzamide (F1431)

Isolated as a tan solid (0.058 g, 94%),

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(3 _f 4 _i ,5-trich!orophenyl)cyciopropane-l- carboxamsdo)-M-(2 _f 6-d!fiuoro-3-(2,2 _f 2-trif!uoroaceta!Ti!do)phenyS}-3- methylbenzamide (F1432)

Isolated as a white solid (0,060 g, 95%),

2-ChSoro-5-((l ?,3?}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethyS)phenyi}cycfopropane-l-carboxamido}-/y-(3-(2 _f 2- dif uoroacetamsdo)-2 _i ,6-dsfSuoropheny!)-3-methy!ben2:am!de (F1468)

Isolated as a white solid (0,056 g, 99%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnfuoromethvOphenyi}cvcfopropane-l-carboxamido}-/y-(2,6-dif uoro-3- (2 _f 2 _f 2-trif!uoroaceta!T!!do)phenyl)-3-methy!benz:a!T!ide (F1469)

Isolated as a white solid (0.058 g, 100%).

2~Chloro~5~((l ? _f 3?)-2 _J ,2~dschSoro~3~(3 _f 4~dichlorophenyf}cycSopropane~l~ carboxamsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 4-dif!uorophenyl)-3~ methy!benzamide (F1484)

Isolated as a tan powder (0,057 g, 100%).

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cyclopropane-i- carboxamsdo)-W-(2 _? 4-d!f!uoro-3-(2 _f 2 _i 2-trif!uoroaceta!T!!do)phen l)-3- methylbenzamsde (F1485)

Isolated as a tan powder (0.058 g.100%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf )cyclopropane-l- carbo3 amido)~i¥~(3~(2 _f 2~d!f uoroacetamido}~2 _f 4~difSuorophenyS)~3~ methy!benzamsde (F1486)

Isolated as a tan powder (0.062 g, 100%).

2~ChSoro-5~{(li? _J ,3i?)~2 _f 2~dich!oro~3~(3,4 _J ,S~trichlorophenyf )cyclopropane-l~ carbo5 amido)~i¥-(2,4~difluoro~3~(2 _f 2 _f 2~trifluoroacetamido)phenyl)-3~ methylbenzamide (F1487)

Isolated as a tan powder (0,060 g, 95%),

2-Ch!oro-S-((l^,3^)-2,2-dschSoro-3-(4-f!uoro-3- (tnfluoromethyS}pheny!)cyc!opropane-I-carboxamido)- f-(3-(2 _i 2- difluoroacetamsdo)-2 _f 4-dsfluoropheny!)-3-methy!ben¾am!de (F1494)

Isolated as a tan powder (0.047 g. 99%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS}phenyi)cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-3- (2,2,2-trif!uoroacetamido)phenyS)-3-methySbenzamide (FI495)

Isolated as a tan powder (0.049 g _f 99%).

2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carboMamsdo}-i¥-(5-(2,2-dif!u3roacetamido}-2 _i .4-difluorophenyS}-3- methylbenzamsde (FI496)

Isolated as a tan powder (0,055 g, 90%),

2~Chloro~5~((l ? _f 3?)-2 _J ,2~dschSoro~3~(3 _f 4~dichlorophenyf}cycSopropane~l~ carboxamsdo)-i¥~(2 _f 4~diffuc5ro~5-(2,2 _? 2-triffuoroacetarnido}phenyS}~3~ methy!benzamide (F1497)

Isolated as a tan powder (0,063 g, 100%).

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3 _? 4 _f S-trich!oropheny )cyc!opropane-I- carboxamsd j)-W-(5-(2 _f 2-d!f uoroacetamido}-2 _? 4-difluorophenyS)-3- methylbenzamsde (F149S)

Isolated as a tan powder (0,067 g, 99%), 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf )cyclopropane-l- carbo3 amido)~i¥-(2 _f 4~difluoro~S~(2 _f 2 _f 2~tnfluoroacetamido)phenyl)-3- methy!benzamsde (F1499)

Isolated as a tan powder (0.066 g, 95%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~ (5~(2 _f 2~

diff uoroac8tamsdo)-2,4~dsfluoroph8nyf }~3-niethyfbenz:am!de (F1500)

Isolated as a tan powder (0.056 g _f 99%).

2-ChSoro-5-((l ?,3 ?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethyl)pheny!)cycSopropane-l-carboxam!do)-W-(2 _f 4-dif uoro-S- (2 _f 2 _f 2-trif!uoroaceta!T!!do)phenyl)-3-methy!benz:a!T!ide (Fi501)

Isolated as a tan powder (0.057 g, 99%).

i¥-{3~Acetamido-2,4-dif!uorophenyl)-2-chloro~S~({l^ _f 3 ?)-2 _i 2~dschforo~3~i3 _f 5~ dichlorophenyS)cyclopropane-l-carbo amido}~3~ffuorobenzaniide (F1502)

Isolated as a tan powder (0.039 g, 52%),

W-{3-Acetamsdo-2 _? 4-difluorophenvl)-2-chloro-S-({l^ _? 3^)-2 _f 2-dsch oro-3-(3 _f 4,5- trich!orophenyl)cyc!opropane~l-carbo3camido)~3~ffuorobenz:ar T!ide (F1504)

Isolated as a tan powder (0,071 g, 44%),

The following compounds were prepared in like manner to the procedure outlined in Example 4;

2~Chloro~5~((J ? _jr 3?)-2 _i 2~dschSoro~3~i3 _f 4~dich!orophenyf}cycSopropane-l~ carboxamsdo)-i¥~(2 _f 4~diffuoro~3-(2 _f 2,3 _f 3~

tetrafluoropropanamido)phenyf)benzamide (F1414)

Isolated as a white foam (0,104 g, 85%),

2~Chloro~i¥-(2 _f 4-dich!oro~3~{2-cyanoacetamido)phenyf)-S~({l _f 3 )~2 _f 2~ dichioro-3-(3,4-dichtorophenyS)cycopropane-l-carboxamido}ben zamide

CF1415)

Isolated as a white so!id (0,110 g, 98%), J¥~(3~(2~Chforo~S~({J _f 3 )~2 _f 2~dichSoro-3-(3 _f 4~dichforophenyS}cvcfopropan8- carbo3amido)ben :amido)~2 _f 6~diffuorophenyS)furan~2~carbo3amide (I

Isolated as a white solid (0.089 g, 76%).

2~ChSorO"W~(3-(2~cycfoprop¾f!acetamido)~2,4~difluorophen yf)~5~i(J ¾ dichforo~3~(3,4~dichSorophenyl)cycopropane~l~carboxamido)ben zaniid

Isolated as a white solid (0,104 g, 91%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cyclopropane~l- carboMamsdo}-i¥-(2 _f 4-d!fiuoro-3-(3,3 _f 3-

Isolated as a white solid (0.103 g, 87%).

■Ch!oro-5~((JI?,3l?J~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cyclopropane~l-

Isolated as a white foam (0.098 g, 84%).

2-ChSoro-5-((I ? _J ,3?}-2 _f 2-dschtoro-3-(3,4-dich!oropheny

carboxamsdo)-i¥-(2 _f 4-d!fiuoro-3-(2 _? 2 _i .3 _f 3 _i 4 _? 4 _i .4- heptaf!uorobutanamido)pheny!)benzam!de (F1463)

Isolated as a white foam (0.087 g, 65%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cvclopropane-i- carbo5amido)~i¥"(3~(2 _f 2~diffuoro~2-phenylacetamsdo)~2 _J ,4~

diffuorophenyl)benzamide (F1471)

Isolated as a light yellow foam (0.086 g, 68%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf)cyc!opropane~l~ carbo3ami ~i¥-(2 _f 4~difluoro~3~prop!onaniidoph8nyf)benzamide (F1472)

Isolated as a white solid (0,074 g, 67%).

W~(3-Butyramsdo~2 _f 4~diffuorophenyS}~2~chSoro~5~i(ll?,3l?}~2 _f 2~dichfc5ro~3-(3,4~ dichforopheny!)cycfopropane~l~carboxamido)benzamide (F1473)

Isolated as a white solid (0,088 g, 79%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf)cyc!opropane~l~ carbo5amido)~i¥"(2,4~difluoro~3~pentanamidophenyf)benzamide (F1474)

Isolated as a white solid (0,092 g, 80%). 2-ChSoro-5~((JI? _J ,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo3amido)~i¥-(2 _f 4~difluoro~3~(3~03ocycfobutane~l~

carboxamsdG}phenyf}benza ide (FI475)

Isolated as a white foam (0.106 g, 91%).

2-ChSoro-5~((ll?,3l)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf)cyclopropane-l- carboMamsdo)-i¥-(2 _f 6-d!fiuoro-3-(2,2 _i .3,3- tetraf!uoropropanamido)pheny!)benzamide (F1534)

Isolated as a white so!id (0.037 g, 65%).

2~Chloro~5~((l ? _f 3?)-2 _J ,2~dschSoro~3~(3 _f 4~dichlorophenyf}cycSopropane~l~ carboxamsdo)-i¥~(2 _f 6~diffuoro~3-(2 _f 2,3 _f 3~

tetrafluoropropanamido)phenyf)benzamide (F153S)

Isolated as a white solid (0.039 g, 67%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l-carbo3amido)~¥~(2,6~ diffuoro-3~ (2,2,3,3~tetrafSuoropropanamido}phenyl)bera:am!de (F1564)

Isolated as a white solid (0.104 g, 76%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf )cvclopropane~l~ carbo3 amido)~i¥~(2 _f 4~difluoro~S~(2 _f 2 _f 3 _f 3"

tetraf!uoropropanamido)pheny!)benzamide (F1565)

Isolated as a white so!id (0.043 g, 58%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 4 _f 5-trichforophenyf )cycfopropane~l~ carboxamsdo)-i¥~(2 _f 4~diff uoro~3-(2 _f 2,3 _f 3~

tetrafiuoropropanamido)pheny )benzamide (F1567)

Isolated as a white solid (0, 107 g, 87%).

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(3 _? 4 _f S-trich!oropheny )c¾ ^r c!opropane-I- carbo5 amido)~i¥-(2,4-difluoro~5~(2 _f 2 _f 3,3~

tetraffuoropropanamido)phenyf )benz:amide (F158S)

Isolated as a white solid (0.096 g, 78%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS}phenyi)cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-5- (2 _f 2 _f 3,3-tetraf!uoropropana!T!ido)pheny!)ben2:amide (FI569)

Isolated as a white solid (0,099 g, 80%). 2-ChSoro-5~((JI? _J ,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo¾amido)~i¥-(3~(2~eth>3ypropanamido)~2 _f 4~dif uorophenyS)benzamsde

(FI604)

Isolated as a white solid (0.093 g, 79%).

2-ChSoro-5~((JI? _J ,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo3amido)~i¥-(3~(2~etho3y~2~niethvf ropanamido}~2 _f 4~

dif uoropheny!}ben¾amide (F1605)

Isolated as a white foam (0.097 g, 81%).

2-ChSoro-5-((I ? _J ,3?}-2 _f 2-dschtoro-3-(3,4-dich!oropheny )cyc!opropane-l- carboMams -i¥-(2,4-d!fiuoro-3-ssobutv'ramidophenvi}benzamide (FI606)

Isolated as a white solid (0.084 g, 75%).

2-ChSoro-5-((I ? _J ,3?}-2 _f 2-dschtoro-3-(3,4-dich!oropheny )cyc!opropane-l- carboMamsdo}-i¥-(2 _f 4-d!fiuoro-3-(3,3 _f 3-tnfiuoro-2- (tnf uoromethv!)propanam!do)phenvl)ben2:amide (FI607)

Isolated as a white solid (0,115 g, 88%).

2-Chloro-5-((I^3^)-2 _f 2-dschSoro-3-(3 _f 4-dich!oropheny )c¾ ^r cSopropane-i- carboxamsdo)-i¥-(3-(2 _? 2-difluirocvclopripane-i-carbixamido)-2 _? 4- diffuorophenyS)ben_iam!de (F1608)

Isolated as a white solid (0,102 g, 87%).

2-ChSoro-M-(3-(l-cyanocycSopropane-l-carboxamWo)-2 _f 4-d!fiuoropheny)-S- (iJi?,3^)~2,2~dichloro~3~(3 _? 4-dichforopheny!)cycfopropane~l~

carbo5amido)ben_iamide (F1609)

Isolated as a white foam (0.090 g, 77%).

W~(3-{2~Chforo~5~((I ?J?}~2 _f 2~dichSoro-3~{3 _f 4~dichforophenyS}cycfopropane~l- carbo amido)b8nzamido)~2 _f 6~diffuorophenyS)tetrahydrofuran~3~carboxamide (F1610)

Isolated as a white foam (0.111 g, 95%).

W~(3-{2~Chforo~5~((I ?J?}~2 _f 2~dichSoro-3~{3 _f 4~dichforophenyS}cycfopropane~l- carboxamido)b8nzamido)~2 _f 6~diffuorophenyS)tetrahydrofuran~2~carboxamide (F1611)

Isolated as a white foam (0.066 g, 56%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cyclopropane~l~ carboxamsdo}-i¥-(3-(2-ethoxy- -methypropanamid3}-2,4- difuoropheny!)benxamide (F1616)

Isolated as a white foam (0.093 g, 79%).

2-ChSoro-M-(3-(2-cyano-M-methv!acetamWo)-2 _f 4-d!fiuoropheny )-S-((l¾3^)- 2 _? 2-dichforo~3~(3 _f 4~dichSorophenyf )cycSopropane~l~carboMam ido}benz:arT!ide (F1817)

Isolated as a white foam (0.096 g, 86%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf )cyc!opropane~l~ carboxamido)-iV-(2,4-difluoro-3-(2-methoxy-Af- niethylacetamido)phenyf )benzamide (F1630)

Isolated as a white foam (0.082 g, 92%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4 _J ,S~trichlorophenyf )cyclopropane-l~ carboxamido)~i¥-(3~(2~ethoxypropanamido)~2 _f 4~dif uorophenyS)benzamsde (F1645)

Isolated as a white solid (0.079 g, 68%). The title compound was prepared from /V-(3-amino-2,4-difluorophenyl)-2-chloro-5-(( l ?,3 ?)-2,2-dic loro-3-(3,4,5- trichlorophenyi) cyclopropane-l-carboxamido)benzamide which was prepared via methods described in U.S. Patent Application Publication US20160304522A1 (F315). 2~Chloro~5~((J ? _jr 3 ?)-2 _i 2~dschSoro~3~i3 _f 4 _f 5~trichforophenyf )cycfopropane~l~ carboxamsdo)"W~(2 _f 4~diff uc5ro~3-(2~methc5xyacetamsdc5)phenyf }benz:arT!ide (F1646)

Isolated as a white solid (0.087 g, 78%).

~(3-(2~Chforo~S~({J _f 3 )~2 _f 2~dichSoro-3-(3 _f 4 _f 5-tnchforophenvl)cycfopropane~ l-carbo amido)benz:amsdo)~2,6~dsfluoroph8nvf)tetrahydrofuran~2~carbo aniide (FI647)

Isolated as a white foam (0.071 g, 77%).

W-{3-(2-Chloro-S-((I¾3^)-2 _? 2-d!chloro-3-(3 _f 4 _f 5-tnchlorophenyS)cyclopropane- l~carboxamido)benzamido)~2 _f 6~difSuorophenyf)furan~2~carboxamide (F164S)

Isolated as a white foam (0.072 g, 62%).

2~Chloro~5~((J ? _jr 3?)-2 _i 2~dschSoro~3~i3 _f 4 _f 5~trichforophenyf)cycfopropane~l~ carboxamsdo)-i¥~(2 _f 4~diffuoro~3-(3~oxocycobutane-l~

carbGxamsdo)phenyl)benzamide (F1649)

Isolated as a white foam (0.040 g, 35%).

2-Ch!oro-i¥-(3-(2-cyanoacetar!i!do)-2,4-d!f uorophenyt}-5-(CJ ?, JU}-2 _f 2- dich!oro-3-(3 _f 4 _f 5-tr!ch!orophenyS)cyc!opropane-I-carboxamido)benzam!de (FI650)

Isolated as a yellow foam (0.062 g. 56%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf )cyclopropane-l- carbo3 amido)~i¥-(2 _f 4~difluoro~3~(3 _f 3 _f 3~

trif!uoropropanamsd j}pheny!)benzamide (F165I)

Isolated as a white foam (0.074 g, 63%).

2-Chloro-5-((I^3^)-2 _f 2-dschSoro-3-(3 _f 4 _i ,5-trich!oropheny cyciopropane-l- carboxamsdo)"W~(2 _f 4~diff uoro~3-(2,2 _? 3 _f 3,4,4,4- heptaf!uorobutanarnido}phenyl)ben_iam!de (F1652)

Isolated as a white foam (0.052 g _f 39%).

2~Chloro~i¥-(3~(2-cyclopropySacetamsdo}~2 _f 4~dsffuoroph8nyf )~S-{{JJ?,3^)~2,2~ dichloro~3~(3,4,5~trichSorophenyl}cycSopropane-l~carboxamido )benzamide (F1653)

Isolated as a white foam (0.099 g, 88%),

2-ChSoro-5-{(Ii?,3i?)-2,2-dsch!oro-3-(3,4,S-trich!orophen y )cyc!opropane-I- carboxamsdo)-W-(2,4-d!f!uoro-3-propionamid ipheny! }ben2:a!T!!de (F16S4)

Isolated as a white foam (0.099 g, 90%).

~(3~Butyramsdo~2 _f 4~dif uorophenyS)~2~chSor >-5~({II? _f 3l?}~2 _f 2~dichforo~3- (3,4,5~trichSorophenyl}cycSopropane~l~carboxamido}benzamide (F165S)

Isolated as a white foam (0.095 g, 85%).

W-(3-Butyramsdo-2,4-dif!u 3ropheny ^, S}-2-chSoro-5-({J ?,3 ?}-2 _i .2-dich 3ro-3-(4- chSoro-3-Ctrif!uoromethyS)phenyS}cyc!opropane-I-carboxarnido )benza!Ti!de (F16S9)

Isolated as a white foam (0.067 g, 75%).

2-Chloro-5-((I^3^)-2 _f 2-dschSoro-3-(4-ch oro-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(3-(2- ethoxypropanamido)~2 _f 4~difluorophenyf )beniarnide (F1860)

Isolated as a white solid (0,071 g, 77%).

W-{3-(2-Chloro-S-((I¾3^)-2 _? 2-d!chloro-3-(4-ch!oro-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)ben2:a!T!!do)-2 _? 6- difluoraphenyl}tetrahydrofuran~2~carboxamsde (F1661)

Isolated as a white solid (0,069 g, 75%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cvclopropane-i- carbo5amido)~i¥"(2,4~difluoro~3~(l~(triffuoromethyS}cycfopr opane-l~ carbo5amido)phenyf)beniarnide (F1862)

Isolated as a white foam (0.033.27%).

(i?}~Af-(3~(2-Chforo~5-(ili?,3^)~2,2-dichloro~3~{3 _i 4~

dichforopheny!)cycfopropane~l~carboxamido)ben2amido)~2,6~

diffuorophenyl)pyrrofidine-2~carbo amide (F1663)

Isolated as a white foam (0.044 g, 38%).

(S)~W~(3~(2~ch!oro~5-(iJi?,3^)~2,2~dichloro~3~{3 _? 4- dichforopheny!)cycfopropane~l~carboxamido)ben2amido)~2,6~

diffuorophenyl)pyrrofidine-2~carbo amide (F1664)

Isolated as a white foam (0.039 g, 33%).

J¥~(3~(2~Chforo~S~({J _f 3 )~2 _f 2~dichSoro-3-(3 _f 4~dichforophenyS}cycfopropan8~l- carbo3amido)b8nzamido)~2 _f 6~diffuorophenyS)isoxa¾oSe~5~carbo3amide (F1671)

Isolated as a white foam (0.069 g, 70%).

J¥~(3~(2~Chforo~S~({J _f 3 )~2 _f 2~dichSoro-3-(3 _f 4~dichforophenyS}cvcfopropan8~l- carboMamsdo)benzamido)-2,6-dif!u 3rophenv'S)ssothiazoie-5-carboxamide (FI672)

Isolated as a white foam (0.059 g, 58%).

2-ChSoro-5-((I ? _J ,J ?}-2 _f 2-dschtoro-3-(3,4-dich!oropheny )cyc!opropane-l- carboMamsdo)-i¥-(2,4-d!fiuoro-3-(2-phenyiacetamsd 3}pheny!)benzamide (F1673)

Isolated as a white foam (0.073 g, 72%).

2-ChSoro-5-((I ? _J ,J ?}-2 _f 2-dschtoro-3-(3,4,5-trichiorophenyS)cyciopropane-l- carboxamsdo)-i¥-(3-(2 _? 2-dichlo!Oacetarnido)-2 _? 4-d!flu iropheny benEamsde (F1685)

Isolated as a white foam (0.104 g, 88%).

2~Chloro~i¥"(3~(2-chforo~2 _f 2~difluoroacetamido)~2,4-diffuoropheny!)-5~

((II¾ _r 3 ?)~2 _f 2~dichSoro-3~{3 _f 4,5~tnchforopheny! )cycfopropane~ l~

carbGxamido}benzarrside {F16S6}

Isolated as a white foam (0.097 g _f 82%). 2-ChSoro-i¥~(3-(2~chloro~2,2~dsffuoroacetamido)~2 _f 4~dif uorophenyS}~5~ ((J ¾3J?)~2 _f 2-dichloro~3~{3-ch!oro~4~fluoroph8nvf}cycSopropane~l~

carboMamsdo)benzamide (FI697)

Isolated as a white foam (0.104 g, 87%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenvl)cycopropane~l~ carbo¾amido)~i¥-(3~(2~eth>3ypropanamido)~2 _f 4~dif uorophenyS)benzamsde (FI69S)

Isolated as a white solid (0.098 g, 83%).

W-(3-(2-Ch!oro-5-((J#?,3#?)-2,2-dichSoro-3-(3-chSoro-4- fuorophenyt)cyc!opropane-I-carboxamsd j}ben¾amido}-2,6- dif uorophenyS)tetrahydrofuran-2-carboxamsde (F1699)

Isolated as a white foam (0.107 g, 91%).

2-ChSoro-W-(3-(2-cyanoacetamido)-2 _f 4-dif!u3rophenyS}-5-{(JW,3^}-2,2- dich!oro-3-(3-ch!oro-4-f!uoropheny!)cvcSopropane-l-carboxami do}benzamide (Fi7Q0)

Isolated as a white foam (0.089 g, 80%).

2-ChSoro-5-((I ? _J ,J?}-2j2-dschtoro-3-(3-ch oro-4-fluoropheny!}cyc!opropa carboxamsdo)-i¥-(2 _f 4-d!fiuoro-3-(3 _? 3 _i .3- trifluoropropanamido)phenyf)beniarnide (F1701)

Isolated as a white foam (0.098 g, 82%).

2-ChSoro-M-(3-(2-cyciopropvlacetamsdo)-2 _? 4-dsf!uoropheny -S-((l^Ji?)-2 _f 2- dichforo~3~{3~chloro~4~ffuorophenyf}cycSopropane-l~carboxami do}ben.iam!de (F1702)

Isolated as a white solid (0,094 g, 82%).

2~ChSoro-5~{(Ji?,3i?)~2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenyl)cycfopropane~l~ carbo3amido)~i¥-(2 _f 4~difluoro~3~(2 _f 2 _f 3 _f 3"

tetraffuoropropanamido)phenyf)benzamid8 (F1703)

Isolated as a white foam (0.110 g, 89%).

2~ChSoro-5~{(Ji?,3i?)~2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenyl)cycfopropane~l~ carbo3ami ~i¥-(2 _f 4~difluoro~3~prop!onaniidoph8nyf)benzamide (F1704)

Isolated as a white foam (0.103 g, 94%).

W~(3-Butyramsdo~2 _f 4~diffuorophenyS}~2~chSoro~5~i (II?, Jl?}~2 _f 2~dichforo~3-(3~ chloro~4~ffuorophenyS)cyclopropane~l-carbo amido}benz:amsde (F1705)

Isolated as a white solid (0,99 g, 88%), 2-ChSoro-i¥~(3-(2~chloro~2,2~dsffuoroacetamido)~2 _f 4~dif uorophenyS}~5~ ((J¾3J?)~2 _f 2-d!chloro~3~{4-ch!oro~3~{trsfluoromethyl)pheny!)cycf >propane~l~ carboMamsdo)benzamide (FI7I9)

Isolated as a white foam (0.54 g, 76%).

2-ChSoro-5-((JI?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l-carbo3 amido)~ ¥~(3~({S)~2~

ethoMypropanamsd j}-2,4-dif!uoroph8ny!)benzamide (F173I)

Isolated as a white foam (0.080 g, 69%).

2-ChSoro-5-((I ? _J ,J ?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uorom8thyS}phenyi}cycfopropane-l-carboxamido}-/y-(3-({W}-2- ethoxypropanamsdo)-2 _i ,4-dif!uorophenyl)benEa!Tiide (FI732)

Isolated as a white foam (0.068 g, 58%).

2-Chloro-5-((I^3^)-2 _f 2-dschSoro-3-(3 _f 4-dich!oropheny )cycSopropane-i- carboxamsdo)-M-(3-(( ?)-2-ethoxyp!Opanam!do}-2 _f 4-d!f uorophenyS)ben¾amsde (F1734)

Isolated as a white foam (0.081 g, 69%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3-chloro-4-fluorop henvl)cycopro carbo amido)~ ~(2,4-difluoro~3~(2 _f 2 _f 3,3 _? 4 _f 4 _f 4~

heptafSuorobutanamido)phen¥f)benzamide (F1741)

Isolated as a white solid (0.051 g, 38%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opr>pan8~l~carb>3amido)~¥ ~{2,4~diffuor>-3~(2~ (triffuorom8thoxy)acetamido)phenyf)benzamide (F1742)

Isolated as a white solid (0.104 g, 86%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3amido)~¥~(2,4~ diffuoro-3~(2~ o opropanamido)phenyS)b8n :am!de (F1754)

Isolated as a white solid (0.035 g, 40%).

2~Chloro~5~((J ? _jr 3?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf}cycSopropane-l~carboxamido}~ ~(2 _f 4~difuoro~3~ (4,4,4-trifiuoro-3-m8thySbutanamido)phenyS}ben2:amsde (FI760)

Isolated as a whi te foam (0.101 g, 82%) .

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4-dich!orophenyl )cvclopropane-i- carbo5 amido)~i¥"(2,4-difluoro~3~(2-

(trifluoromethaxy)acetamido)phenyl)beniarriide (F 1766)

Isolated as a white foam (0.100 g, 82%) .

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf )cyc!opropane~l~ carbo amido)~i¥-(2 _f 4~difluoro~3~(2~

(triffuorom8thoxy)propanam!do)phenyS}b8nramide (F 1767)

Isolated as a white foam (0.096 g, 78%) .

2~ChSoro-5~{(Ji?,3i?)~2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenyl)cycfopropane~l~ carbo amido)~i¥-(2 _f 4~difluoro~3~(2~

(triffuorom8thoxy)acetamido)phenyf )benzamide (F 1768)

Isolated as a white foam (0.101 g, 83%) .

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenyl)cyc opropane~l~ carbo amido)~i¥-(2 _f 4~difluoro~3~(2~

(tnf uorom8thoxy)propanamido)phenyS}b8nzamide (F 1769)

Isolated as a white foam (0.109 g, 87%).

5-C(H?,3i?)-2 _i 2-D!chSoro-3-(3 _i 4 _? S-tnch!oropheny cvciopropane-l- carboxamido)~i¥"(2,6~difluoro~3~(2~(triff uoromethoxy}acetamido)pheny!)~2,3- difluorobenzamide (F1777)

Isolated as a white foam (0.058 g, 83%).

W-{3-(S-{(Ii?,3i?)-2 _? 2-Dich!oro-3-{3 _i ,4 _? 5-tr!chSor iphenv'l)cycSopropane-l- carboxamsdo)-2 _J ,3~dsf!uorobenzarnido)~2,4~difluoropheny!)tetrahydrofu ran~2~ carboxamsde (F1778)

Isolated as a white foam (0.046 g, 68%),

5-C(H?,3i?)-2 _i 2-D!chSoro-3-(3 _i 4 _? S-tnch!oropheny cvciopropane-l- carboxamsdo)-W-(2 _? 6-d!f!uoro-3-(2 _f 2,3,3,4, 4,4- heptafSuorobutanamido)phenyf )-2,3~dif!uorobenzamide (F1779)

Isolated as a white foam (0.053 g, 70%). 2-ChSoro-5~((JI? _J ,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo amido)~i¥-(2 _f 4~difluoro~3~(2~(triffuorom8thoxv}acetamido)pheny!)~J� �~ methv!benzamsde (F1793)

Isolated as a white foam (0.107 g, 88%).

-ChSoro-5~((JI? _J ,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~

Isolated as a white foam (0.088 g, 75%).

2-ChSoro-5-((I ? _J ,3?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethyS}phenyi}cvcfopropane-l-carboxamido)-/y-f2,4-dif uoro-3-(2- (tnf uoromethoxy)acetamsdo)pheny )-/¾'-methy!ben2:a!T!!de (FI796)

Isolated as a white foam (0.095 g, 79%).

2-ChSoro-5-((I ? _J ,3?}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethyS)phenyi}cycfopropane-l-carboxamido)-/y-f3-(2- ethoxypropanarnsdo)-2 _i ,4-dif!uorophenyl)-^-f^st^¥^benza!Ti!de (F1797)

Isolated as a white foam (0.092 g, 79%).

W-{3-(2-Chloro-S-((I¾3^)-2 _? 2-Dich!oro-3-(4-f uoro-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-methylben2:a rn!do)- 2 _f 6~diffuorophenyl)tetrahydrofuran~2~carbaxamsde (F1798)

Isolated as a white foam (0.098 g, 84%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(4-fSuoro-3-

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~ (2,4~diffuoro~3~ (4,4,4~triffuorobutanamido)phenyf)ben-iamide (F1800)

Isolated as a white foam (0.11 g, 92%).

frans~5~(3-{3 _f 5~MsiTrifluoromethyf}phenyS}~2 _f 2~dichforocycSopropane-l~ carbo3amido)~2~chSoro~ ~(2,4~diffuoro~3~(2~

(triffuorom8thoxy)acetamido)phenyf)benzamide (F1804)

Isolated as a white foam (0.106 g, 89%).

frans~M~(3~iS~(3~i3 _f 5~&s{Triffuoromethyl)phenyf)~2 _f 2~dichSorocycfopropane~l~ carbo5amido)~2~chSorobenzamido)~2,6~difluorophenyf)tetrahydr ofuran~2~ carbojami

Isolated as a white foam (0.105 g, 91%).

frans~5~(3-{3 _f 5~MsiTrifluoromethyf}phenyS}~2 _f 2~dichforocycSopropane-l~ carbo5amido)~i¥-(3~butyramido~2 _f 4~difluorophenyf)~2~chlorobenz:amide

(F1806)

Isolated as a white foam (0.098 g, 89%).

f-(3-{2-Ch oro-5-((i ^J ?)-2 _f 2-d!chSoro-3-{4-f!uoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diff uorophenyl)isoxazofe~5~carboxamide (FIB 16}

Isolated as a white foam (0.078 g, 84%).

f-(3-{2-Ch oro-5-((i ^3 ?)-2 _f 2-d!chSoro-3-{4-f!uoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diff uorophenyl)isothiazofe~5~carbc5Mamide (F1817)

Isolated as a white foam (0.036 g, 38%).

W~(3-{2~Chforo~5~((I ? J ?}~2 _f 2~dichSoro-3~{4~ffuoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diff uorophenyl)iso azofe~3~carboxamide (FIB 18}

Isolated as a white foam (0.067 g, 72%).

W~(3-{2~Chforo~5~((I ? J ?}~2 _f 2~dichSoro-3~{4~ffuoro-3- (triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3 amido)ben¾amido)~2 _f 6~ diff uorophenyl)-l-{2 _f 2,2~trsfluoro8thyS}~lH~pyraTOfe~3-carbo3 aniide (F3

Isolated as a white foam (0.070 g, 67%).

f-(3-{2-Ch oro-5-((i ^J?)-2 _f 2-d!chSoro-3-{4-f!uoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diffuorophenyl)-l _? 2 _f 3~thiadia.ioSe~5~carboxarnide (F1820)

Isolated as a white foam (0.040 g, 42%).

W~(3-{2~Chforo~5~((I ?J?}~2 _f 2~dichSoro-3~{4~ffuoro-3- (triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3amido)ben¾amid o)~2 _f 6~ diffuorophenyl)~3-{trifluoromethyf)isoxa :oSe~5-carbo amide (F1824)

Isolated as a white foam (0.024 g, 24%).

frans-S-{3-(3 _f S-fcis(Trif!uoromethyl)phen l)-2 _f 2-dsch iTOcyclopropane-i- carboxamsdo)-2-chloro-Af-{2 _? 4-dif!uoro-3-(2 _f 2 _f 3 _i ,3 _? 4 _f 4 _f 4- heptaf!uorobutanarnido}phenyl)ben_iam!de (F1825)

Isolated as a white foam (0.105 g, 80%).

2-Chloro-5-((I^3^)-2 _f 2-dschSoro-3-(4-fluoro-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(2 _f 4-dif uoro-3- (4 _f 4 _f 4~trifluoro~3~{triffuoromethy!)butanarnido)phenyS}ben- iam!de (F1833)

Isolated as a white foam (0.114 g, 86%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(4-fSuoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(3~ (4 _f 4~ diffuoropentanamido)~2 _f 4~difSuorophenyl)ben-iarnide (F1843)

Isolated as a white foam (0.100 g, 84%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cyc!opropan8~l~carbo3amido)~¥~(2,4~ diffuoro-3~

~pentaf!uoropentanamido)phenyf)benzamide (F1844)

Isolated as a white foam (0.101 g, 88%).

2-ChSoro-5-((JI?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS}phenyi)cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-3-(2- (2,2,2-trif!uoroeth3xy}acetar!i!do}phenyt}benxamsde (F1846)

Isolated as a white foam (0.119 g, 80%).

ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4-dich! enyi)c¥dopropane-i- rbo5amido)~i¥-(2,4-difluoro~3~(4 _f 4 _f 4~trifl amsdo)pheny!)benzamide

Isolated as a white foam (0.105 g, 86%).

iSoro-5~{(Ji?,3i?)~2 _f 2~dich!oro~3~(3~chforo~4-f!uorophenv!)cycfopropane~l~ carl so¾amido)~i¥~(2 _f 4~difluoro~3~(4 _f 4 _f 4~tnflu >robutanamsdo}ph8nyf)benzamid8 (F1848)

Isolated as a white foam (0.101 g, 83%).

W~{3~{l~AcetyScycfopropane~l~carboxamido)-2 _? 4-dsf!uoropher

((lH,3J?)~2,2-dichloro~3~{4-fSuoro~3~(triffuoromethyf)phenyl )cycopropane~l~ carbo3amido)b8nzamide (F1850)

Isolated as a white solid (0.044 g, 42%).

loro~5~((J ? _jr 3?)-2 _i 2~dschSoro~3~i3 _f 4~dich!orophenyf}cycS«

amsdo)~i¥~(3~(4 _f 4-diffuoropentanamido}~2 _f 4~difSuorophenyS)b8ra:am!de (F1860)

Isolated as a white solid (0,103 g, 85%).

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4-dich!orophenyl)cvciopropane-i- carbo5amido)~i¥-(2,4~difluoro~3~(4 _f 4 _f 5,5 _? 5-pentafSuoropentanamido)phenyS) benzams

Isolated as a white foam (0.119 g, 92%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf)cyclopropane~l~ carbo¾amido)~i¥~(2 _f 4~difluoro~3~(4 _f 4 _f 4~tnfluoro~2~m8thySbutanamido)phenyS} benzamid

Isolated as a white foam (0.047 g, 38%).

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-dichforophenyf)cyc!opropane~l~ carbo¾amido)~i¥-(2 _f 4~difluoro~3~(2~(2 _f 2,2-triffuoroethoxy)acetamido)phenyl) benzami

Isolated as a white foam (0.109 g, 88%).

2-ChSoro-5~((JI?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenyl)cyc opropane~l~ carbo3amsdo)-i¥-(3-(4,4-dif!u3ropentanamido}-2,4-difluoroph eny!}benxar!iide (FI864)

Isolated as a white foam (0.100 g, 83%) .

2-ChSoro-5-{(Ii?,3i?)-2,2-dsch!oro-3-(3-chloro-4-fluoroph env'l)cyc opropane-l- carbo5 amido)~i¥-(2,4~difluoro~3~(4 _f 4 _f 5,5 _? 5-pentafSuoropentanamido)phenyS) benzams

Isolated as a whi te foam (0.113 g, 86%) .

2~ChSoro-5~{(Ji?,3i?)~2 _f 2~dich!oro~3~(3~chforo~4-f!uorophen¾fl)cycfopropane~l ~ carbo¾amido)~i¥~(2 _f 4~difluoro~3~(4 _f 4 _f 4~tnflu >ro~2~m8thySbutanamido)phenyS} benzamid

Isolated as a white foam (0.094 g, 75%) .

2~ChSoro-5~{(Ji?,3i?)~2 _f 2~dich!oro~3~(3~chforo~4-f!uorophen¾fl)cycfopropane~l ~ carbo¾amido)~i¥-(2 _f 4~difluoro~3~(2~(2 _f 2,2-triffuoroethoxy)acetamido)phenv ^, l) benzami

Isolated as a white foam (0.115 g, 92%) .

2-ChSoro-5~(( ll?,3 l)~2 _f 2~dich!oro~3~{3,4~dichforophenyf )cyclopropane~l~ carbo3 amido)~i¥~(2 _f 4~difluoro~3~(2~ff uoroacry!aniido)phenv! )benzamide (FI871 )

Isolated as a white foam (0.047 mg, 42%),

2~£Η1θΓθ-5~{(1ί?,,3ί?)~2,2~€ϊεΗ!θΓθ~3~(3,4 ,,5~ίΓΪεΗΙθΓο Η8πν!}ενεΙο Γο 3ηθ-1~ carboxamido)~i¥-(2,4~difluoro~3~(2~ff uoroacry!amido)pheny!)benzamide (F1872)

Isolated as an off-white foam (0,053 g, 47%),

W-{3-(But-3-enamido}-2 _i 4-difSuorophenv!)-2-chSoro-S-((Ii? _f 3i?)-2 _i ,2-dsch!oro-3- (3 _f 4-d!chSorophenv'l)cycSopropane-I-carboxam!do}ben2:am!d e (F1873)

Isolated as a white foam (0.065 g, 69%).

W-{3-(But-3-enamido}-2 _i 4-difSuoropheny!)-2-chSoro-S-((Ii? _f 3i?)-2 _i ,2-dsch!oro-3- (4~ffuoro~3~(trifSuoromethyl)phenyf )cycSopropane~l~carbc5Mam!do}benz:amsde (F1S74)

Isolated as a white foam (0.097 g, 87%).

i¥-{3~(But-3~enamido}~2 _f 6~difSuoropheny!)~5~((l ? _f 3l?)~2 _f 2~dichSoro-3~i3 _f 4,5~ trich!orophenyS)cyc!opropane~l-carbo3camido)~2,3~difluoroben -iarnide (F1875)

Isolated as a white foam (0.054 g, 84%).

W-{3-(But-3-enamido}-2 _i 4-difSuorophenv!)-2-chSoro-S-((Ii? _f 3i?)-2 _i ,2-dsch!oro-3- (3~chloro~ ~ff uorophenyf }cyclopropane~l~carboxarnido}ben.5:am!de (F1876)

Isolated as a white foam (0.074 g, 66%).

W-{3-AcrySamido-2,4-dif!uoropheny -2-chloro-S-(( ii? _f 3 ₁ )-2 _? 2-dichloro-3-(4- ffuoro~3-(trif!uoromethyS)phenyl)cyc!opropane~l~carboxamido) beniamide (F1S77)

Isolated as a white solid (0.041 g, 21%).

The following compounds were prepared In like manner to the procedure outlined In Example 5:

i¥-(3-Acetamsdo-2,4-dich!orophenyt)-2-ch oro-5-((lW _f 3W)-2,2-dich!oro-3-(4- f!uoro-3-(tnfluoromethyS}phenyi}cyc!opropane-l-carboxam!do)b enzamide (FI4I2)

Isolated as a white solid (0.043 g, 29%).

i¥-(3-Acetamsdo-2,4-difluoropheny!}-5-((lR,3R}-2 _f 2-dichtoro-3-{3,4,5- tr!chSorophenyl)cycSopropane-l-carboxam!do)-2 _f 3-d!fiuoroben2:a!T!!de (FI433)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy oil (0.086 g, 76%).

fert-Butyl (3-{2-εΗΙθΓθ-5-((Ιί?,3ί?)-2,2-«^!εΗ!θΓθ-3-(3 _? 5- dich!oropheny cyciopropane-i-carboxamido)ben2:amsdi)-2 _? 4- diffuorophenyl)carbamate (¥1434)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a white solid (0.330 g _f 88%).

ferf-Buty {3-(2-chSoro-5-((l ?,3?}-2 _f 2-dichtoro-3-(3,4- dich!orophenyt)cyc!opropane-l-carboxamido)benxamsdo}-2,4- dif§uorophenyl)carbamate (F143S)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a white solid (0.270 g, 76%).

ferf-Butyf {3~{2-chloro~5~((l ? _f 3?)-2 _i 2~dichSoro-3~i3 _f 4 _f 5~

trich!orophenyS)cyc!opropane~l-carbo3camido)ben-iarnido}~ 2 _f 4~

diffuorophenyS)carbamate (F1436)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a white foam (0.320 g, 81%),

5-((l/?,3?)-2,2-Dichloro-3-C3,4,5-trichlorophenyl)cyclopropa ne-l- carboxamsdo)-M-(3-(2 _? 2-d!fluoroacetamido)-2 _f 4-difluoriphenyl)-2 _f 3- diffuoroberwamsde (F1437)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a brown powder (0,050 g, 38%),

5~({l^ _f 3?)-2 _? 2~Dich!oro~3~(3 _? 4 _f S~tnch!orophenyS}cyc!opropane-l- carboxamsdo)-i¥~(2 _f 4~diffuc5ro~3-(2,2 _? 2-triffuoroacetarnido}phenyS}~2 _f 3~ difluorobenzamide (F1438)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.058 g, 48%).

i¥-(3~Acetamido-2,4-dif!uorophenyl)-5-((l l,3l)~2 _f 2-dich!oro~3~{3,5- dichiorophenyS)cyciopropane-l-carboxamido}-2 _f 3-difluoroben2:amsde (F1439)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy oil (0.024 g, 21%) ,

5-((I ? _f 3i?)-2 _i 2-D!chSoro-3-(3 _i 5-dichlorophenyS)cyc!opropane-I-carboxamsdo}- f-(3-{2,,2-difSuoroacetarn!do)-2 _? 4-d!flu iropheny -2 _f 3-dif!uor iben2:amsde

(F1440)

The title compound was synthesized with a reaction time of 24-48 hours and isolated s a glassy oil (0.040 g, 32%) .

5~{{H? _? 3i?)~2 _f 2~DichSoro~3~(3 _f 5~dichforophenyS}cyclopropane-l~carbo5 amido}~

W~{2 _J ,4~diffuoro-3~{2 _f 2,2~tnfluoroacetamido)phenyS)~2 _f 3~difSuoroben-5:amsde

(F1441)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy oil (0.028 g, 22%) .

W-{3-Acetamsd 3-2 _f 4-difluorophenyS}-S-{(li? _f 3i?)-2,2-d!chSoro-3-(3 _f 4- dich!orophenyt)cyc!opropane-l-carboxamido}-2,3-diff uorobenxamsde (F1442)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a paie sol id (0. 100 g _f 84%) .

5-(C l ?,3 ?}-2 _i .2-DichSoro-3-(3 _f 4-dich 3rophenyS)cvciopropane-l-carboMamsdo}- W-{3-(2 _f 2-d!fluoroacetam!do)-2 _f 4-d!f uorophenyS)-2 _i 3-difSuoroben¾amsde (F1443)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy oil (0.085 g, 67%) .

5~{( l^ _f 3^}-2,2~Dich!oro~3~{3,4-dichforopheny!)cycfopropane~l~ carboxamsdo)- i¥~(2 _f 4~diflu >ro~3~(2,2 _f 2~tnfSuoroacetaniido)pheny!)~2,3~dif!uoroben2amide (F1444)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.058 g, 45%) .

ferf-Butyf (3-{2~chSoro-5-{( li? _i 3i?)~2 _f 2~dich!oro~3~(3~chforo~4~

ffuoropheny!)cycfopropane~l~carboxamsdo)ben2amido)~2,4- diff uorophenyl)carbamate (F 1445)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a foamy solid (0.325 g, 98%).

2-ChSoro-5-((l ?,3 ?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethv ^, S}phenyi}cycfopropane-l-carboxamido}-/ '-(3-( -ethv -2,2- dif uoroacetamsdo)-2 _i ,4-dsfSuorophen¥!)benza!Ti!de (F1452)

Isolated as a white foam (0.148 g, 94%).

ferf-Buty -M-({fert-butox¥)carbonyS)-M-[3-[[5-[[C l^ _f 3^)-2 _f 2-dich! iro-3-(3 _f 4- dich!orophenyS)c¥c!opropanecarbonynamino]-2-f!uoro-ben2:oyl ]amm i3-2 _? 6- diff uoro~phenyi]carbarnate (F1453)

Isolated as a colorless oil (0,661 g, 76%).

2-Ch!oro-S-((J^3^)-2,2-dschSoro-3-(3-ch!oro-4-fluoropheny S}cyc opropane-l- carboxamsdo}-W-(3-(2 _f 2-dif uoro-/y-methy!acetar!i!do)-2,4- difluoropheny^benzamide (FI460)

Isolated as a white foam (0.117 g, 78%),

2-ChSoro-5-{(Ii?,3i?)-2,,2-dsch!oro-3-(3 _? 4 _f S-trich!oropheny )cyc!opropane-I- carboxamsdo)-W-(3-(2 _f 2-d!f uoro-W-methylacetamido)-2 _f 4- diff uorophenyl)benzamide (F1461)

Isolated as a white foam (0.119 g, 82%).

2-ChSoro-5~((JI? _J ,3l?)~2 _f 2~dich!oro~3~{3,5~dichforophenyf )cvcfopropane~l~ carbo3 amido)~i¥-(3~(2 _f 2~d!f uoro~ ~methyf cetamido)~2 _f 4~

dif uoropheny!)benxamide (F1462)

Isolated as a white foam (0.111 g, 75%).

W-{3-(W-Ayy!-2 _f 2-dsf!uoroacetamWo)-2 _f 4-d!fiuoropheny )-2-ch oro-5-((I^ _? 3 ?)- 2 _f 2~dichforo~3-(4~fSuoro~3~(tnf!uoromethyl)phenyf )cyc!opropane~l~

carboxamsdo)benzamide (F14B2)

Isolated as a clear, colorless oil (0.052 g _f 33%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3- (trif!u jromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-(2 _f 4-dif!

methySacetamsd j}pheny!)benzamide (F1506)

Isolated as a white foam (0.057 g, 39%),

S-{(JW,3^)-2,2-Dichtoro-3-(3,4-dich!orophenyt)cyc!opropan e-I-carboxamsdo}- M-(3-{ ,2-difSuoroacetam!do)-2 _? 6-d!fluoropheny -2"f^Groben¾am!de (F1512)

Isolated as a white solid (0,068 g, 46%).

5~{{ll?,3i?)~2 _f 2~DichSoro~3~(3 _f 4~dichfc5rophenyS}cyclopropane-l~carbo5amido}~ W~{2 _J ,8~diffuoro-3~{2 _f 2,2~tnfluoroacetamido)phenyS}~2~fluorobenzamide (F1S13)

Isolated as a white solid (0.064 g, 42%).

W~(3-Acetamsdo~2 _f 6~difSuorophenyS)~5~{(JI¾ _r 3l?)~2 _i 2~dichSoro-3~{3 _f 4~ dichforopheny!)cycfopropane~l~carboxamido)~2-fluorobera:am!d e (F1514)

Isolated as a white foam (0.031 g, 24%).

5~{{ll?,3i?)~2 _f 2~DichSoro-3~i3 _f 4,5~tnchforopheny!)cycfopropane~l~

carbo3amido)~i¥-(2 _f 4~difluoro~3~(2 _f 2 _f 2~tnfluoroacetamido)phenyl)-2- fluoroberwa ide (F1S26)

Isolated as a white solid (0.083 g, 56%).

5~{{lR _f JU}-2 _i .2-DichSoro-3-(3 _f 4 _f 5-tnch!orophenyt)cyc!opropane-I- carboxamsdo)-i¥-(3-(2 _? 2-difluiroaceta!T!ido)-2 _i .4-difluoriphenyl)-2- fuorobenzamide (F1527)

Isolated as a white solid (0.065 g, 46%).

~(3-Acetamsdo~2 _f 4~difSuorophenyS)~5~((J^3^)~2,2~dichSoro-3~{3 _f 4 _f 5~ trichSorophenvl}cycSopropane-l~carboxamido)~2-ff uorobenzamide (F1S28)

Isolated as a brown solid (0,088 g, 65%),

5-{(lR _f JU}-2 _f 2-DichSoro-3-(4-f!uoro-3-(trifiuoromethy!)phenv'S}cyc 3propane-l- carboxamsdo)-M-(2 _f 4-d!fiuoro-3-(2,2 _f 2-trif!uoroacetam!do)phenyS}-2- ffuorobenzamide (F1529)

Isolated as a white solid (0, 100 g, 67%).

5-{{1^3^)-2 _i .2-Dich!oro-3-(4-fSuoro-3-{tr!f!uoromethyl)phenvl)cyc opropane-l- carboxamsdo)- f-(3-(2 _? 2-diflu iroaceta!T!ido)-2 _i .4-difluor iphenvl)-2- ffuorobenzamide (F1530)

Isolated as a white solid (0.095 g, 66%).

{3-acetamsdo-2 _f 4-difluorophenyS}-5-((I^3^)-2 _f 2-d!chSoro-3-(4-fluor i-3- ide

Isolated as a brown solid (0, 117 g, 85%) ,

ferf-Butyf {3-{2~chSoro-5-((Ji?,3i?)~2 _f 2~dich!oro~3~(3,4- dichforopheny!)cycfopropane~l~carboxamido)benzamido)~2,6~

diff uorophenyl)(methyS)carbamate (F1549)

Isolated as a colorless glass ( 1.05 g, 98%) .

5~{{ll?,3i?)~2 _f 2~DichSoro-3~i3 _f 4,5~tnchforopheny!)cycfopropane~l~

carboxamido)-iV-(2,4-difluoro-5-(2 _r 2,2-trifluoroacetamido)phenyl)-2- f uorobenzamide (F I551)

Isolated as a yellow foam (0.087 g, 59%).

5~{{lR _f JU}-2 _i .2-DichSoro-3-(3 _f 4 _f 5-tnch!orophenyt)cyc!opropane-I- carboxamido)-/V-(5-(2,2-difluoroacetamido)-2,4-difluoropheny l )-2- f uorobenzamide (F 1552)

Isolated as a yellow foam (0.073 g, 51%),

i¥"{5~Acetamido-2,4-dif!uorophenyl )-5-{(Ji?,3i?)~2 _f 2~dichloro~3~(3 _? 4 _i S~ tr!ch!orophenyS )cyc!opropane~l-carbo amido)~2~ff uorobenz:arT!ide (F15S3)

Isolated as a white foam (0.081 g, 60%).

5-{(II?,JI?)~2 _f 2~DichSoro~3-(3 _f 4 _f 5-tnchforopheny!)cvcfopropane~l~ carbo¾amido)~i¥-(2 _f 6~difluoro~3~(2 _f 2 _f 2~tnflu >roacetamido)phenv ^, l)-2- f uorobenzamide (FI554)

Isolated as a white foam (0.092 g, 63%).

5-{{1^3^)-2 _i .2-Dich!oro-3-(3 _f 4 _f S-tnch!orophenyS)c¾ ^r c!opropane-I- carboxamsdo)"i¥~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenvl)-2~ ffuorobenzamide (F15S5)

Isolated as a white foam (0.073 g, 51%).

i¥-(3~Acetamido-2,6-dif!uorophenvl)-5-((J ¾3 l)~2 _f 2-dich!oro~3~{3,4,S~ trich!orophenyS)cvc!opropan8~l~carbo3 amido)~2~ff uorobenzamid8 (F15S6)

Isolated as a white solid (0.083 g, 61%).

S-{(JW,3^}-2,2-Dichtoro-3-(4-fSuoro-3-{trif!uoromethyl)ph eny!}cyc!opropa carboxamsd 3}-W-(2,4-dif!u 3ro-5-(2,2,2-trif!uoroacetamido)phenv'S}-2- fluorobenzamide (FIS57)

Isolated as a white foam (0.114 g, 76%).

5~{{ll?,3i?)~2 _f 2~DichSoro~3~(4~fluoro-3~{trifluoromethyf }phenyS}cycfc5propane- ca amido)~i¥"(5~(2 _f 2~diffuoroacetarnido}~2 _f 4~difSuorophenyS)~2~

enzamide (F1S58)

Isolated as a yellow foam (0.112 g. 77%).

-Acetamsdo~2 _f 4~difSuorophenyS)~5~((J^3^)~2,2~dichSoro-3~{4~fluoro-3 - uorom8thyS}phenyl)cyc!opropan8~l~carbo3 amido)~2~ff uorobenzamid8 (FI559)

Isolated as a white foam (0.122 g, 89%).

5-{(II?,3J?)~2 _f 2~DichSoro~3-(4~fluoro-3-{trifluoromethyf )phenyS}cycfopro

carboxamido)-Af-(2,6-difluoro-3-C2 _r 2,2-trifluoroacetamido)phenyl)-2- fl

Isolated as a white foam (0.128 g, 86%).

5-((J/? _/ -3 ?)-2,2-Dichloro-3-C4-fluoro-3-(trifluorom ethyl )phenyl)cyclopropane-l- f uorobenzamide (F156I)

Isolated as a white foam (0.101 g, 70%).

W~(3-Acetamsdo~2 _f 6~difSuorophenyS)~5~((JI¾ _r 3l?)~2 _i 2~dichSoro-3~{4~fluoro-3~ (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~2~ffuor obenz:amide (F1S62)

Isolated as a white solid (0.108 g, 79%).

~(3-Acetamsdo~2 _f 4~difSuorophenyS)~5~((l^ _f 3^)~2,2~dichSoro-3~{4~fluoro-3- (triffuorom8thyS}phenyl)cyc!opr>pan8~l~carb>3amido)~2 _f 3"^if^<>roben¾am!de (FI570)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.046 g, 61%).

5-{{l^ _i 3^)-2 _i .2-Dich!oro-3-(4-fSuoro-3-{tr!f!uoromethyl)phenyl)cyco propane-l- carboxamsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 4-dif!uorophenyl)-2 _J ,3~ difluorobenzamide (F1571)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy white solid (0.054 g, 68%). 5-{(ll?,3J?)~2 _f 2~DichSoro~3-(4~fluoro-3-{trifluoromethyf )phenyS}cycfopro carbo¾amido)~i¥-(2 _f 4~difluoro~3~(2 _f 2 _f 2~tnflu >roacetamido)phenv ^, l)-2,3~ diff uorobenxamsde (FI572)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.057 g, 70%) .

5~({l^ _f 3 ?)-2 _? 2~Dich!oro~3~(4~fSuoro~3~(tr!ffuorornethyf )phenyl)cycfopropane~l~ carboxamsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenyl)-2 _J ,3~ difluorobenzamide (F1573)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.024 g, 29%) .

5-((I ? _f 3i?)-2 _i 2-D!chSor i-3-(4-fluoro-3-Ctrif!uoro!T!ethy )phenyS}cyclopropane-I- carboxamsdo)-W-(2,6-d!f!uoro-3-(2 _f 2 _i 2-trif!uoroaceta!T!!do)phenyl)-2 _i .3- difluorobenzamide (F1S74)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.060 g, 73%) .

W-{3-Acetamsd 3-2 _f 6-difluorophenyS}-S-{(li? _f 3i?)-2,2-d!chSoro-3-(3 _f 4- dich!orophenyS)cyc!opropane-i-carboxamido}-2 _? 3-difluoroben¾amsde (F1S7S)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.062 g, 91%) .

W-(3-Acetamsd j-2 _f 6-difluorophenyS }-S-{( li? _f 3i?)-2,2-d!chSoro-3-(4-f!uoro-3- (tnf uoromethv! )pheny!)cycSopropane-l-carboxam!do)-2 _f 3-d!fiuoroben2:a!T!!de (F1576)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.055 g, 73%) .

5~{( l^ _f 3^}-2,2~Dich!oro~3~{3,4-dichforopheny!)cvcfopropane~l~ carboxamsdo)- i¥-(3~(2,2~difluoroacetamido)~2 _f 6~dif uorophenyS)~2 _f 3~difSuorobenz:amsde (F1577)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.058 g, 72%) .

5~{{ H? _? 3i?)~2 _f 2~DichSoro~3~(3 _f 4~dichforophenyS}cyclopropane-l~carbo5 amido}~ J¥~(2,6~diffuoro-3~(2 _f 2,2~tnfluoroacetamido)phenyS)~2 _f 3~difSuorobenz:amsde

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.048 g, 65%) .

5-(( l/?,3 ?)-2,2-Dichloro-3-C3,4,5-trichlorophenyl)cyclopropane-l- carboxamsdo)-M-(2 _f 4-d!fiuoro-S-(2 _? 2 _f 2-trif!uoroacetam!do)phenyS}-2 _? 3- diff uoroberwamsde (F 1S79)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.055 g, 68%) .

5-(( l/?,3 ?)-2,2-Dichloro-3-C3,4,5-trichlorophenyl)cyclopropane-l- carboMamsdo}-i¥-(5-(2,2-dif!u 3roacetamido}-2 _i .4-difluorophenyS }-2j3- diff uoroberwamsde (F 1S80)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.061 g, 82%) ,

W-{5-Acetarnsdo-2 _? 4-difluoropheny!)-5-{( Ii? _f 3i?)-2 _i ,2-dich!oro-3-{3 _i .4 _f S- trich!orophenyS )cyc!opropane-I-carboxamido)-2 _? 3-dif!uorobenza!Ti!de (F1S8I)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.055 g, 70%) .

5-(( I ? _f 3i?)-2 _i 2-D!chSoro-3-(3 _i 4-dichlorophenyS)cyc!opropane-I-carboxamsdo}- M-(2 _f 4-d!fiuoro-5-{2,2 _? 2-tnfluoroacetam!do}phenyS)-2 _? 3-difluoroben¾amsde (F1SS2)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.053 g, 68%) .

5-(( l ?,3 ?}-2 _i .2-DichSoro-3-(3 _i .4-dich 3rophenyS)cvciopropane-l-carboMamsdo}-

W-(5-(2j2-difSuoroacetar!i!do)-2,4-d!f uorophenvt)-2,3-diff uorobenxamsde

(F1S83}

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a glassy solid (0.052 g, 61%) .

5~({ l^ _f 3 ?)-2 _? 2~Dich!oro~3~(4~fSuoro~3~(tr!ffuorornethyf )phenyl)cycfopropane~l~ carboxamsdo)-i¥~(2 _f 4~diff uoro~5-(2 _f 2,2-triffuoroacetamido)phenyS}~2 _f 3~ difluorobenzamide (F 1584)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.057 g, 74%) ,

W-{5-Acetamsd 3-2 _f 4-difluorophenyS }-S-{( li? _f 3i?)-2,2-d!chSoro-3-(3 _f 4- dich!oropheny cyc!opropane-i-carboxamidol- ^-difluorobenxamsde (FiSSS)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a brown glassy solid (0.060 g, 79%) .

5~{( l^ _f 3^}-2,2~Dich!oro~3~{4-fSuoro~3~{triffuoromethyf )phenyl)cyc opropane~l~ carboxamsdo)-i¥~(5-(2 _f 2-diffuoroacetamido)~2,4-dif!uorophenyl }-2,3~ diHuorobenzamsde (F 1586)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.054 g, 72%) .

W~(5-Acetamsdo~2 _f 4~difSuorophenyS )~5~{( ll? _f 3l?)~2 _i 2~dichSoro-3~{4~fluoro-3~ (triffuoromethyS }phenyl)cyc!opropane~l-carbo3camido)~2,3~difluoroben-iarnide (F1S87)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.055 g, 69%) .

5-(( l/?,3 ?)-2,2-Dichloro-3-C3,4,5-trichlorophenyl)cyclopropane-l- carboxamido)-Af-(2,6-difluoro-3-C2 _r 2,2-trifluoroacetamido)phenyl)-2 _r 3- diff uoroberwamsde (F 1S88)

The title compound was synthesized with a reaction time of 24-48 hours and isolated s a glassy solid (0.060 g, 83%) .

5-{{ l^ _i 3^)-2 _i .2-Dich!oro-3-(3 _f 4 _f S-tnch!orophenyS)cyc!opropane-I- carboxamsdo)-i¥~(3-(2,2~diffuoroacetamido)~2 _? 6-dif!uorophenyl )-2 _J ,3~ dif!uorabenzamsde (F 1589)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.046 g, 58%) ,

W-{3-Acetarnsdo-2 _? 6-difluorophenyl )-5-{( Ii? _f 3i?)-2 _i ,2-dich!oro-3-{3 _i .4 _f S- trich!orophenyS )cyc!opropane-I-carboxamido)-2 _? 3-dif!uorobenza!Ti!de (F1S90)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a giassy solid (0.066 g, 98%) . ~(3-Acetamsdo~2 _f 4 _f 6-tnf!uorophenvl)-2-chloro~5~{( l^ _f 3^}-2,2~dschSor >-3~(4~ ffuoro~3~(trifSuoromethvl)ph8nyf )cycSopropane~l~carbo amido)benzamid8

(FI6I3)

Isolated as a white so!id (0.076 g, 52%).

i¥-(3~Acetamido-2,4 _f 6~tnfSuorophenyS)~2~chSoro-5-{( ll?,3l?)~2 _f 2~dich!oro~3~{3~ chSoro-4-fluoropheny!)cycfopropane~l~carboxamido)ben2amide (F1627)

Isolated as a white solid (0,081 g, 55%).

M-(3-Acetamsdo-2 _f 4,6-tnfluorophenv'l)-2-chlo!O-S-{{ l^ _i 3^)-2 _f 2-dschSoro-3- (3,4~dich!orophenyS)cyc!opropane~l-carbo3camido)ben-iamide (F1629)

Isolated as a white solid (0,095 g, 64%).

frans~i¥~(2~Acetamido~3 _f S~d!ffuorophenyf )~2~chforo~5~(2 _f 2~dichSoro-3~{3 _f 5~ dichforopheny!)cycfopropane~l~carboxamido)benzamide (F1632)

The tlt!e compound was synthesized with a reaction time of 24-48 hours and isoiated as a waxy soiid (0.038 g, 50%) .

fra«s~ ¥~{2~Acetamido~4 _f 6~diffuoroph8nyf )~2~chf >ro~S~(2 _f 2~dichSoro~3-{3 _f S~ dichforopheny!)cycfopropane~l~carboxamido)ben2amide (F1633)

The title compound was synthesized with a reaction time of 24-48 hours and isoiated as a paie waxy soi id (0.035 g, 46%) .

frans-/y-(2-Acetarii!do-4,5-dif!uoropheny!)-2-ch!oro-5-(2 ,2-dichSoro-3-(3 _f 5- dich!orophenyt)cyc!opropane-l-carboxamido)benxamsde (F1634)

The title compound was synthesized with a reaction time of 24-48 hours and isoiated as a paie sol id (0.061 g, 80%) .

fraiis~ ¥~{5~Acetamido~2-ffuorophenv!)~2~chforo~S~{2,2~dichforo~3~( 3,S~ dichforopheny!)cycfopropane~l~carboxamido)ben2amide (F1635)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a paie waxy sol id (0.042 g, 54%) .

frans-/y-(2-Acetarii!do-6-f uorophenvt}-2-ch oro-5-(2,2-d!ch!oro-3-(3,5- dich!orophenyt)cyc!opropane-l-carboxamido)benxamide (F1636)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a waxy pale sol id (0.041 g, 55%) .

fraiis~ ¥~{2~Acetamido~4-ffuorophenv!)~2~chforo~S~{2,2~dichforo~3~( 3,S~ dichforopheny!)cycfopropane~l~carboxamido)ben2amide (F1637)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a paie semi solid (0,020 g, 24%) ,

frans~i¥~(3~Acetamido~4-ffuoropheny!)-2~chforo~S~(2 _ir 2-dichforo~3~{3 _i S~ dichforopheny!)cycfopropane~l~carboxamido)benzamide (F163S)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a paie sol id (0.007 g _f 10%) .

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS)cyci 3propane-l- carboMamsdo)-i¥-(3-f!uoro-5-(2,2,2-trif!u 3roacetamido}phenyi}benzamide (F1639)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a pale sol id (0.011 g, 13%) .

trans~2~Chforo~5-(2,2-dichloro~3~{3,5-dichforopheny!)cycf opropane~l~ carboxamsdo)-i¥~(2-f!uoro-5~(2 _f 2 _f 2~triffuoroacetamido)phenyf }benzaniide

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a paie sol id (0.020 g, 23%) .

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-C3 _? 5-dichlorophenyS)cyc!opropane-I- carbo5 amido)~i¥-(4~ff uoro~3-(2,2 _J ,2~triffuoroacetamido}phenyl)ben-iamide (F1841 )

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a paie sol id (0.015 g, 21%) ,

ferf-Buty W-£ ^, ert-butoxycarbonyhi¥-[S-[[2-ch oro-5-[[{ l^ _i 3^)-2 _f 2-dschSoro- [4-fluoro-3- (triffuorom8thyS}phenyl]cv'c!opr>pan8carbonyl]am!no]benz: oyf]amino]~2,4- difluQro- ~methyhpheny!]carbamate (F1670)

Isolated as a white solid (0,240 g, 88%).

ferf-Buty /¥-fert-butoxycarbonyhi¥-[3-[[2-ch oro-5-[[Cl?,3?}-2 _f 2-dschtoro-3- [3-fluoro-5-

(tnf uoromethy!)pheny!]cycSopropanecarbony!]amino]benzoyna' iino]-2 _i 6- diffuoro~pheny!]carbarnate (F1681)

Isolated as a white foam (1.14 g, 86%).

W~(4-Bromo~2~methyf~3~nitrophenyf)~2-chforo~5~{(ll? _f 3l?)~2 _f 2~dichSoro-3~{4~ ffuoro~3~(trifSuoromethyl)ph8nyf)cycSopropane~l~carbo amido)benzamid8 (FI68S)

Isolated as a yellow foam (0.140 g _f 92%).

ferf-Buty {5-(2-chSoro-5-((l?,3?}-2 _f 2-dichtoro-3-(4-fSuoro-3- (tnfuorom8thyS}phenyi}cycfopropane-l-carboxamido)benzamido)- 2 _f 3,4- trif!uoropheny carbamate (FI736)

Isolated as a white foam (0.288 g, 90%).

2-ChSoro-5-((ll?,3 l)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethvOphenyi}cvcfopropane-l-carboxamido}-/y-(2,4-dif uoro-3- sodopheny benzamsde (F1758)

Isolated as a white foam (0.338 g, 71%).

ferf-Butyf {3-(2-chSoro-5-((l ?,3 ?}-2 _f 2-dichtoro-3-(4-fSuoro-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)ben2:a!T!!do)-2 _? 6- dif uorophenyS)(ethy!)carbamate (FI761)

Isolated as a white foam (0.540 g, 54%).

2~Chloro~5~((l ? _f 3l?)-2 _J ,2~dschSoro~3~(3 _f 4~dichlc5rophenyf }cyclopropane~l~ carboxamsdo)-i¥~(4-f!uoro-3~(2 _f 2 _f 2~triffuoroacetamido)phenyf }benzaniide (F1812)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a foamy solid (0.140 g, 92%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3 _f 5~dichlorophenyf )cycSopropane~l- carboxamsd j}-W-(4-fluoro-3-(2 _f 2j2-tr!f uoroacetamido}pheny!}benzar!i!de

(FI8I3)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a pale solid (0,142 g _f 93%).

2-ChSoro-5-((l ?,3?}-2j2-dschtoro-3-(3-ch oro-4-fluorophenv!}cv'c!opropane-l- carboxamsdo)-M-(4-fluoro-3-(2 _f 2,2-tr!fluoroacetamido)phenv ^, !)ben2:a!T!!de (F18i4)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a pale solid (0,133 g, 90%).

2~Chloro~5~((l ? _f 3?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenvf)cycSopropane~l~carboxamido)~M~(4~flu oro-3~(2 _f 2,2~ trifluoroacetamido)phenyl)benzamide (F1S1S)

The title compound was synthesized with a reaction time of 24-48 hours and isolated as a pale solid (0.136 g, 87%).

The following compounds were prepared In like manner to the procedure outlined In Example 6:

2-Ch!oro-S-((l^,3^)-2,2-dschSoro-3-(4-f!uoro-3- (trifluoromethyl)phenyl)cyclopropane-l-carboxamido)-V-(3-(2, 2- dich!oropropanamsdo)-2 _? 4-dif!uorophenyl)benEamide (F135i)

Isolated as a white solid (0.062 g, 49%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethv ^, S}phenyi}cvcfopropane-l-carboxamido}-/y-(3-(2 _f 2- dif uoropropanam!do)-2,4-dif uoropheny!)benxamsde (F1352)

Isolated as a white solid (0,134 g, 74%).

W-(3-(2-Bromo-2-methypropanamid3}-2,4-dif!uoropheny!)-2-c h!oro-5- ((I¾3 ?}-2 _f 2-d!chSori-3-C4-fluoro-3-{trif!u iromethy )phenyS}cyclopropi carboxamsdo)ben2:am!de (FI354)

Isolated as a white solid (0.038 g, 29%).

2-Chloro-W-(3-(2 _f 2-d!bromoacetam!do)-2 _? 4-d!f!uoropheny -S-({I ? _i .3?}-2 _i 2- dichloro~3~{4~ffuoro~3-(triffuoromethyS)phenyl)cyc!opropane~ l~

carbGxamido)benzarrside (F1355)

Isolated as a white solid (0,111 g, 79%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuoromethyS}phenyl)cyc!opropane~l-carbo amido)~i¥~(3~(2 _f 2~ diffuorobutanamido}~2 _f 4~diffuc5rophenyS}ben-5:amsde (F13S7)

Isolated as a white solid (0.165 g, 89%). Soro-5-((ll?,3l?)~2 _f 2~dich!

uorom8thyS}phenyl)cvc!opropan8~l-carbo3 amido)~ ¥~(2,4~diff uoro-3~(l- !cyck

Isolated as a white solid (0.107 g, 89%).

2-ChSoro-5-((l ?,3 ?}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethvOphenyi}cvcfopropane-l-carboxamido}-/y- ethoxyacetam!do)-2 _? 4-d!fluorophenyl)ben2:amsde (FI363)

Isolated as a white foam (0.106 g, 88%).

2-Chloro-5-(( l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluor i-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W- ethoxypropanamido)~2 _f 4~difluorophenyf )beniarnide (F!3*

Isolated as a white solid (0.101 g, 82%),

2-ChSoro- f-(3-(2-cyanoacetam!do)-2 _f 4-d!f uorophenyS)

dichforo~3~(4~ffuoro~3~(triff uoromethyl)phenyf )cycS

carbo amido)ben_iamide (F1369)

Isolated as a yellow foam (0.112 g, 96%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3 amido)~ ¥~(2,4~diff uoro-3~ propionamidopheny benzamide (F1371)

Isolated as a white solid (0.180 g, 78%).

2-ChSoro-5-((l ?,3 ?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uorom8thyS}phenyi}cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-3- pentanamsdopheny benzamide (FI372)

isolated as a white foam (0.191 g, 80%).

i¥-(3-Butyramsdo-2,4-d!f uoropheny!}-2-chtoro-5-(( IW _f 3W}-2,2-dich!oro-3-(4- f!uoro-3-(tnftuorometbyS}phenyi}cyc!opropane-l-carboxam!do)b enzamide

(FI38S)

Isolated as a white solid (0.103 g, 88%).

2-ChSoro-5-{(Ii? _f 3i?)-2,,2-dscb!oro-3-(4-fSuoro-3-

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~ (2,4~diff uoro~3~ (2,2,3 _J ,3 _f -heptafSuorobutanamido)phenyl)benzamide (F1450)

Isolated as a white foam (0.119 g, 85%). ~(3-Acetamsdo~2 _f 6~difSuorophenyS)~2~chSoro-5-{(ll?,3l?)~2 _f 2~dichforo~3~{4~ ffuoro~3~(trifSuoromethvl)ph8nyf)cycSopropane~l~carbo amido)benzamid8

(FI454)

Isolated as a white foam (0.168 g, 65%).

W-{3-(2-Bromopropanamido)-2,4-difluorophenv!}-2-ch!oro-5- {(lW _f 3^}-2,2- dich!oro-3-(4-f uoro-3-(trif!uoromethy!}pheny!)cycSopropane-l- carboxamsdo)ben2:am!de (FI479)

Isolated as a white solid (0,120 g, 93%).

W-{3-(2-Chloro-S-((i^ _f 3^)-2 _? 2-d!chloro-3-(4-f!uoro-3- (tnf uoromethy!)phenv ^, !)cycSopropane-l-carboxam!do)ben2:a!T!!do)-2 _? 6- diffuorophenyS)tetrahydrofuran~3~carboxamsde (F14S0)

Isolated as a white foam (0.104 g, 85%).

2~Chloro~5~((l ? _f 3?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf)cycSopropane~l~carboxamido)~M~(2 _f 4~diffuoro~3~ (2 _f 2 _f 3 _f 3"tetraf!uorocydobutane-l~carbo amido}phenyl)ben¾amide (F1481)

Isolated as a white foam (0.114 g, 86%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cv ^, c!opr>pan8~l~carb>3amido)~¥~{2,4~diffuor>-3~ ssobutyramidopheny!)benxar!i!de (F14S3)

Isolated as a white solid (0.108 g, 92%).

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnfuorom8thvOphenyi}cvcfopropane-l-carboxamido}-/y-(2,4- difuoro-3-(3- oxocyciopentane-I-carboxamido)pheny ben2:amsde (F1488)

Isolated as a gold foam (0.113 g, 91%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(2 _f 4-dif uoro-3-(3- methoxypropanamido)phenyl)benzamide (F14B9)

Isolated as a white foam (0.094 g, 78%),

f-(3-{2-Ch oro-5-((I ? _? 3 ?)-2 _f 2-d!chSoro-3-{4-f!uoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo amido)ben-iarnido}~2 _f 6~ diffuorophenyl)oxetane~2-carbo amide (F1S03)

Isolated as a white solid (0,036 g, 30%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cv ^, c!opr>pan8~l-carb>3amido)~¥~{3~(2 _f 2~dimethyh3- OM3CVciobutane-l-carboxamido}-2,4-diffuorophenv!}ben¾ar!iid e (F1507)

Isolated as a white foam (0.054 g, 44%),

2-Ch!oro-S-((l^,3i?)-2,2-dschSoro-3-(4-f!uoro-3-

(trif!ujromethvt}phenv!}cv'cSopropane-l-carboxamido}-i¥- (3-(2-eth3xy-2- methvlpropanam!do)-2 _f 4-d!f uorophenyS)ben¾am!de (F1603)

Isolated as a clear, colorless oil (0.047 g, 38%).

(2S _f SS)-M-C3-{2-ChSoro-5-C(ii? _f 3^)-2 _? 2-dich!oro-3-{4-fSuoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diffuorophenyl)-5~methy!tetrahydrofuran~2~carboxamide (F1612)

Isolated as a white foam (0.100 g, 80%). ~(3-(2~Chforo~S~({l _f 3 )~2 _f 2~dichSoro-3-(4~ffuoro-3- (triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)ben¾amid o)-

Isoiated as a white solid (0.110 g, 88%).

W-(3-(2-Ch!oro-5-((I#?,3^)-2,2-dichSoro-3-(4-f!uoro-3- (tnfuorom8thvOphenyi}cvcfopropane-l-carboxamido}benzamido)- dif uorophenyS)-S-ethytetrahydrofuran-2-carboxamsde (F1626)

Isolated as a clear colorless oil (0,105 g, 82%),

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxamido)-W-(2 _f 4-dif methySbutanarnido}phenyS}ben_iam!de (F1642)

Isolated as a white solid (0.092 g, 77%).

2~Chloro~i¥-(3~(cycfopentanecarboxamido)~

dichloro~3~{4~ffuoro~3-(triffuoromethyS)phenyl)cyc!opropa ne~l- iamido)benzarrside (F1643)

Isolated as a white solid (0.086 g, 70%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l-carbo3amido)~¥~(3~(3 _f 3~ dif uorocyc!obutane-l-carboKamido}-2 _f 4-difluorophenyS}ben2:amide

Isolated as a white solid (0.100 g, 79%).

2-ChSoro-W-(3-(2-chioropropanamsdj}-2,4-dif!uoropheny!)-5-(( lW _f 3W)-2,2- dich!oro-3-(4-f uoro-3-(trif!uoromethy!}pheny!)cycSopropane-l- carboxamsdo)ben2:am!de (FI667)

Isolated as a white solid (0,112 g, 92%).

2-Chloro-W-(3-(2-ch!orobutanamsdo)-2 _f 4-d!fluoropheny )-S-((i^ _f 3^)-2 _? 2- dich!oro-3-{4-f uoro-3-(trifluoromethyS)pheny!)cv'clopripane-i- carboxamsdo)benzamide (F166S)

Isolated as a white solid (0.097 g, 78%).

2~Chloro~i¥-(3~(3-chforobutanamido)~2 _i 4~difluorophenyf)~5-(il^ _f 3^)~2,2- dichloro~3~{4~ffuoro~3-(triffuoromethyS)phenyl)cyc!opropane~ l~

carbGxamido)benrarrside (F1669)

Isolated as a white solid (0,097 g, 78%). ~(3-(2~Chforo~S~({l _f 3 )~2 _f 2~dichSoro-3-(3~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)ben¾amid o)~2 _f 6~ diffuoropheny!)tetrahydrofuran-2-carboxamsde (F1676)

Isolated as a white solid (0.076 g, 82%).

2-ChSoro-5~((ll?,3l)~2 _f 2~dich!oro~3~{3~(trifSuoroni ethyl }phenyf )cycSopropane- l-carboxamido}-/¥-(2 _f 4-dsfSuoro-3-(2,2,3 _f 3- tetraf!uoropropanamido}pheny!)benzamid8 (F1677)

Isolated as a clear colorless oil (0.061 g, 63%).

W-(3-Acetamsdj-2 _f 4-difluorophenyS}-2-chSoro-5-(Cl?,3?}-2 _f 2-dsch oro-3-(3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)ben2:a!T!!de (F1678)

Isolated as a white solid (0.070 g, 81%).

2-ChSoro-W-(3-(2-cyc!opropy!acetamsdo)-2 _f 4-dsfiuoropheny )-5-({l#?,3^)-2 _f - dich!oro-3-(4-f uoro-3-(trif!uoromethy!}pheny!)cycSopropane-l- carboxamsdo)ben2:am!de (FI6S2)

Isolated as a white foam (0.113 g, 94%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)~¥~(2,4~ diffuoro- (3 _f 3 _? 3-tnf!uorQpropanamsdo)phenyl)benzamide (F1683)

Isolated as a white foam (0.114 g, 91%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS}phenyi}cvcfopropane-l-carboxamido)-/y-(2,4-dif uoro-

Isolated as a white foam (0.082 g, 68%).

(^)-/¥~(3-(2~Chforo~S~((l^ _f 3 )~2 _f 2~dichSoro~3-(4~ffuoro~3- (trif!ujromethyt}pheny!}cycSopropane-l-carboxamido}benzam

Isolated as a white foam (0.103 g, 84%),

(S)-i¥-(3-i2-Chtoro-5-((IW _f 3^}-2,2-dich!oro-3-i4-fluoro-3- (tnfluoromethyS}pheny!)cyc!opropane-I-carboxamido)benza!Ti!d o)-2 _f 6- difluorophenyl)tetrahydrofuran-2-carboxamsde (F1692)

Isolated as a white foam (0.088 g, 72%).

W~(3-{2~Chforo~5~((l ?,3 ?}~2 _f 2~dichSoro-3~{3~ffuoro-5- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diffuorophenyl)tetrahydrofuran~2~carbo3amide (F1706)

Isolated as a white solid (0,060 g, 65%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(3-fluori-S-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxamido)-W-(2 _f 4-dif uoro-3- (2 _f 2 _f 3 _f 3~tetraf!uoropropanamido)phenyf)benzamide (F1707)

Isolated as a clear, colorless oil (0.066 g, 69%).

i¥-(3~Acetamido-2,4-dif!uorophenyl)-2-chloro~5~{(l^ _f 3^}-2,2~dschforo-3~(3~ f!uoro-5-(tnfluoromethyS}phenyi}cyc!opropane-l-carboxam!do)b enzamide (F1708)

Isolated as a white solid (0,057 g, 67%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{3~fSuoro~5~

(triffuorom8thyS}phenyl)cv ^, c!opr>pan8~l~carb>3amido)~¥~{2,4~diffuor>-3~ propionamidopheny benzamide (F1709)

Isolated as a white so!id (0.063 g, 73%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(3-fluori-S-

(triffuoromethy!)phenyf)cycSopropane~l~carboxamido)~M~(2 _f 4~diffuoro~3~ (3 _f 3 _f 3~trifluoropropanamido)phenyf)ben-iarnide (F1710)

Isolated as a white so!id (0.068 g, 73%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3-

(trif!ujromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-( 2 _f 4-dif!uoro-3-(2- rneth?xypropanam!do)phenyS}ben¾am!de (F1712)

Isolated as a white solid (0.110 g, 91%).

f-(3-{5-((I¾3^)-3-(3-Bromo-4-f!uoropheny -2 _? 2-d!chlorocyclopropane-I- carboxamsdo)-2-chSoroben2:am!di)-2 _? 6-dif!uorophenyl)tetrahydrofuran-2- carboxamid

Isolated as a white solid (0,036 g, 59%). 5-{(II?,3l?)~3~(3~Bromo~4~f!uorophenvf }-2,2~dschSorocvcfopropane~l carbo3 amido)~2~chSoro~/¥~(2,4~diffuoro~3~(2 _f 2,3,3- tetraf!uoropropanamido)pheny!)benzamide (F1715)

Isolated as a white solid (0.030 g, 47%).

i¥-(3~Acetamido~2,4-dif!uorophenvl)-5~((l l,3 l)~3~(3-bromo-4~ffuoropheny!)- 2 _f 2~dichforocycSopropane-l~carboxamido)~2~chforoben¾ami de (F1 16)

Isolated as a white solid (0.037 g, 66%).

5~{(l^ _f 3^}-3-(3~Bromo-4~fSuorophenyl)~2 _f 2~dich!orocyclopropane-l- carboxamsd j}-2-ch!oro-/¥-(2,4-difiuoro-3-props 3namsdopheny!}ben¾ar!iide

Isolated as a white solid (0.042 g, 73%).

5-{(ll?,3l?)~3~(3~Bromo~4~f!uorophenyf }-2,2~dschSorocycfopro

carboMamsdo}-2-chSoro-/¥-(2,4-dif!uoro-3-(3,3,3- trif!uoropropanamsd j}pheny!)benzamide (F1718)

Isolated as a white solid (0,031 g, 50%),

2-Chloro-5-(( l^,3^)-2 _f 2-dschSoro-3-(4-fluoro-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(2,4-dif uoro-3-((S)- 2~methoxypropanamido)phenyf )beniamide (F1720)

Isolated as a white solid (0, 101 g, 84%).

W~(3-{2~Chforo~5~((l ?,3 ?}~2 _f 2~dichSoro-3~{4~ffuoro-3- (triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3 amido)ben¾amido)~2 _f 6~ diff uorophenvl)tetrahydrothiophene-2-carbo amide (F1721)

Isolated as a white solid (0.110 g, 88%).

i¥-{3~(2-Chforo~5-(il^ _f 3^)~2,2-dichloro~3~{4-f!uoro~3~

(triffuoromethv!)phenvf }cycSopropane-l~carboxamido)benzamido)-2,6~ dif uorophenyS}tetrahvdro-2H-pvran~3-carbo amide (F1722)

Isolated as a white solid (0.102 g, 82%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3-

(trif!u jromethvt}phenv!}cv'cSopropane-l-carboxamido}-i¥-(2 _f 4-dif!uoro-3-(2- methoxyacetamsd 3}ph8ny!)benzam!de (F1724)

Isolated as a white solid (0.098 g, 83%).

2-Ch!oro-J¥-(3-(2-ch!oroacetam!do)-2,4-d!f uoropheny!}-5-(C l ?,3 ?}-2 _f 2- dich!oro-3-(4-fluoro-3-(trif uoromethvl)phenv!}cvcSopropane-i- carboxamsdo)ben¾amide (F1726)

Isolated as a white foam (0.090 g, 76%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l-carbo3amido)~¥~(3 ~(2 _f 3~

dichforopropanamido)~2,4-difluorophenyf)benzamide (F1728)

Isolated as a white foam (0.060 g, 47%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(trifluoromethyl)phenyl)cyclopropane-l-carboxamido)-Af- 2,4-difluoro-3-C3- fuoropropanariiido)phenyt}benxamsde (F1735)

Isolated as a white solid (0,100 g, 85%).

2-ChSoro-5-((l ?,3?}-2j2-dschtoro-3-(3-(trsfSuoror!iethy!}pheny!)cycSopropa ne l-carboxamido)-W-(3-{2-ethoxypropanarnsdo)-2 _i ,4-dsfSuo!Opheny!)benza!Ti!de

Isolated as a white solid (0,077 g, 83%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(3-(trsfluorimethy!)pheny cyclopripane- l-carboxamido)-W-(2 _f 4-dsfluoro-3-{3 _? 3 _? 3- tnf!uoropropanamido)phenyl)beniarnide (F1738)

Isolated as a white solid (0,078 g, 83%).

Soro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

uoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(2,4~difl

propoxypropanamido)pheny!)ben2amide (F1739)

Isolated as a white solid (0,101 g, 81%).

^~(5-Acetamsdo~2 _f 3 _f 4-tnf!uorophenyl)-2-chloro~5~{(l^ _f 3^}-2,2~dschSoro-3~(4- luoro~3~(trifSuoromethyl)ph8nyf)cycSopropane~l~car

(FI743)

Isolated as a white foam (0.078 g, 92%).

am

((Ii?,3#?)-2,2-dichSoro-3-(4-f!uoro-3-(tnfiuoromethy!)phenyS )cycopropane-l-

Isolated as a white solid (0.081 g, 85%).

!orQ-5-(ilJ?,3i?)~2 _f 2~dich!oro~3~C4~f!uoro

luoromethyS)phenyi)cycfopropane-l

ssobutoxypropanamido)phenyS)ben2:amsde {¥114

Isolated as a white foam (0.067 g, 70%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuorom8thyS}phenyl)cv ^, c!opr>pan8~l~carb>3amido)~¥~{2,4~diffuor>-3~ (2~ (2,2,2~triffuoroethoxv)propanamido}phenyl)ben¾amide (F1747)

Isolated as a white foam (0.081 g, 82%).

~(3-(2~Chforo~S~({l _f 3 )~2 _f 2~dichSoro-3-(4~ffuoro-3- (tnf uoromethyS}phenyi}cycfopropane-l-carboxamido)benzamido)-2 _f 6- dif uoropheny!)-3-methytoKsrane-2-carboxamide (FI748)

Isolated as a white so!id (0.028 g, 31%).

2-Ch!oro-i¥-(3-(2-cyano-i¥-r!iethy!acetar!i!do}-2 _f 4-difiuoropheny )-5-({l ?,3 ?}- 2 _f 2-dich jro-3-(4-fluoro-3-(tnfluoromethyi}pheny }cyc!opropane-l- carboxamsdo)ben¾amide (F1752)

Isolated as a white foam (0.062 g, 72%),

2-ChSoro- f-(3-(2-cyanopropanamsdo)-2 _f 4-d!fluoropheny )-S-((i^ _f 3^)-2 _? 2- dich!oro-3-(4-fluoro-3-(trif uorometh l)pheny!}cycSopropane-i- carbo5amido)ben_iamide (F1755)

Isolated as a white solid (0,067 g, 75%).

2~ChSoro-W~(3-(2~cyanobutanamido)~2 _f 4~difSuoropheny!)~5~((ll?,3 ?}~2 _f 2~ dichforo~3~(4~ffuoro~3~(triff uoromethyl)ph8nyf )cycSopropane-l~

carboxamidG)benzamide (F1756)

Isolated as a white solid (0.033 g, 36%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS)phenyi)cycfopropane-l-carboxam

ethoMybutanamido}-2,4-difiuoropheny )benzamide

Isolated as a white solid (0,026 g, 28%).

2-ChSoro-5-((l ?,3 ?}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(3-(2- ethoxypentanam!do)-2 _? 4-difluorophenyS}ben¾am!de (F1759)

Isolated as a white solid (0.096 g, 75%).

2~Chloro~i¥-(3~(2-cyano~i¥-ethylacetamid >}~2 _f 4~difSuoropheny!)~S~({l^ _f 3 )~ 2 _f 2~dichforo~3-(4~fSuoro~3~(tnf!uoromethyl)phenyf )cyclopropane~l~ carbGxamsdo)benxamide (F1763)

Isolated as a white foam (0.071 g, 81%).

2~£Η1θΓθ-Μ~(3-(2~εν3πο-Μ~ ΐΗγ1 Γο 3Π3ΓηΪ€ΐο)~2,4~€ΐϊΏυοΓο Ηθπν!)-5~ί(1 ?,3ί?}~ 2,2-dichforo~3~(4-f!uoro-3~(tnfSuoroni ethyl }ph8nyf )cycSopropane~l- carbo3camidG)benzamide (F1764)

Isolated as a white foam (0.061 g, 68%).

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS}phenyi)cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-3-(2- (tnf uoromethoxy)propanamido)phenyS}benzamide (F1771)

Isolated as a tan foam (0.080 g _f 82%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(3~fluoro-5-

(trif!u jromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-(2 _f 4-dif!uoro-3-(2- (trif!u jromethoMy)acetamsd 3}pheny!)benzamide (F1772)

Isolated as a white foam (0.032 g, 36%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(3~fSuoro~S~

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(2, 4~diff uoro~3~(2~ (triffuorom8thoxy)propanamido)phenyS}b8nramide (F1773)

Isolated as a white foam (0.043 g, 47%).

2-ChSoro-5~((ll?,3l)~2 _f 2~dich!oro~3~{3~(trifSuoroni ethyl }phenvl )cycSopropane- l-carboxamido}-/¥-(2j4-dsfSuoro-3-(2- (tnf uoromethoxy)acetamsdo)pheny )benz:amide (F1774)

Isolated as a tan foam (0,071 g, 79%),

2-ChSoro-5-((l ?,3R}-2j2-dschtoro-3-(3-(trsfSuoror!iethy!}pheny!)cycSopropa ne- l-carboxamido)-W-(2 _f 4-dsfluoro-3-{2-

(tnf uoromethoxy)propana!T!!do)phenyl)ben2:amide (FI775)

Isolated as a white solid (0,073 g, 80%).

5-{{l^ _? 3^)-3-{3-Bromo-4-fSuoropheny!)-2 _i ,2-dsch!orocyc!opropane-I- carboxamsdo)-2-chloro-Af-{2 _i ,4-dif!uoro-3-(2- (tr!f!uoromethoxy)aeetamsdo)pheny!)benzamide (F1780)

Isolated as a white solid (0.070 g, 79%).

5~({l^ _f 3?)-3~{3~Bromo~4~fSuorophenyl)~2 _f 2~dich!orocyclopro

carboxamsdo)-2~chloro~Af~{2 _f 4~difluoro~3~{2~

(triffuorometho y)propanamido)phenyl)benzamide {F17S1}

Isolated as a white solid (0,074 g, 82%).

W~(3-{2~Chforo~5~((l ?,3 ?}~2 _f 2~dichSoro-3~{4~ffuoro-3- (triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3 amido)ben¾amido)~2 _f 6~ diff uorophenvl)-2,3 _f 3 _f 4 _f 4,5 _f 5~heptaff uorotetrahydrofuran~2~carboxamide (FI782)

Isolated as a white solid (0,079 g, 73%).

W~(3-{2~Chforo~5~((l ?,3 ?}~2 _f 2~dichSoro-3~{4~ffuoro-3- (triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)ben-iarn ido}~2 _f 6~ diff uorophenyl)-2,3 _f 3 _f 4,4,5 _f 5 _f 6 _f 6-nonaf uorotetrahydro~2 ~pyran~2~ carboxamsde (F17S3)

Isolated as a white soiid (0,033 g, 29%).

2-ChSoro-5-((l ?,3 ?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-W-(3-(/¥-ethy -2- (triffuorometho5 y)acetamsdc5)-2 _J ,4~d!f!uorophenyf )benz:amide (F1789)

Isolated as a white soiid (0.058 g, 61%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l-carbo3amido)~¥~{3 ~(2~

(dsfSuororiiethoxy}acetamido)-2 _f 4-dif!uorophen¥S}benzamide (FJ

Isolated as a white foam (0.078 g, 84%).

2-ChSoro-5-((l?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnfuoromethvOphenyi}cycfopropane-l-carboxamido}-/y-(2,4- difuoro-3-(2- (perfluoroethoxv ^, )acetamido)phen¥l)benzamsde (F1S08)

Isolated as a white solid (0,078 g, 76%).

W-{3-(2-Chloro-S-((i^ _f 3^)-2 _? 2-d!chloro-3-(4-f!uoro-3- (tnf uoromethy!)phenv ^, !)cycSopropane-l-carboxam!do)ben2:a!T!!do)-2 _? 6- diffuorophenyS}~2~methyStetrahydrofuran~2~carboxamide (F1809)

Isolated as a white solid (0.061 g, 65%).

2~Chloro~i¥-(3~(2-cyano~i¥-(prop~2~yn~l~yS)acetamido}~2 _f 4~difSuorophenyl)~5~ ((ll? _f 3 ?)~2 _f 2~dichSoro-3~{4~fluoro-3~{trifluoromethyf}phenyS}cycfo propane~l- carbGxamido)benzarrside (F1810)

Isolated as a white foam (0.144 g, 99%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)~¥~(2,4~ diffuoro-3~ -2-yn-I-yn-2-ftrifluorome†

Isolated as a clear, colorless oil (0.027 g, 20%),

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ,2-dsch!oro-3-(4-fSuoro-3-

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~ (2,4~diffuoro~3~(l~ ((tnfSuorometho3cy)rnethyf)cyc!opropane~l~carboxamido)phenyl )benzamide

Isolated as a white solid (0.024 g, 24%).

thy! 3-{(3-(2~ch!oro~5-(ili? _i 3^)~2,2~dichloro~3~(4~fSuoro~3~

triffuoromethy!)phenyf)cycSopropane~l~carboxamido)benza

iffuorophenyS}amsno)~2-ffuoro~3~oxopropanoate (F1822)

Isolated as a white foam (0.097 g, 100%).

2~Chloro~i¥-(3~(2-cyano~i¥-(2~fSuoroethy!)ac8tamsdo}-2, 4~dsfluoroph8nyf)- ({l^ _f 3 )~2 _f 2~dichSoro-3-{4~fluoro-3~(tnfluoromethyf)phenyS}cycfop ropan€

Isolated as a white foam (0.053 g, 68%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cvc!opr>pan8~l~carb>3amido)~N~ {3~(2~etho y~ - ethytpropanamidj)-2,4-dif!uoropheny!)benzamide (F1827)

Isolated as a go!d oil (0.065 g, 71%).

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3- (tnf uoromethyS)phenyi}cycfopropane-l-carboxamido)-/y-(3-(2- (dsfluoromethoxy)propanamido)-2 _i ,4-difSuorophenyl)benEamide

Isolated as a white foam (0.037 g, 39%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxamido)-W-(2 _f 4-dif uoro-3- (4 _f S _f 5 _f 5~tetraf!uoro~4~{trifSuoromethyf)pentanamido)phenyf)be nzamide

Isolated as a white foam (0.081 g, 75%).

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~(2, 4~diffuoro~3~ -triffuoropentanamido)phenyl)benzamide (F1S30)

Isolated as a white solid (0.070 g, 72%). i¥~(3~(2~Bromo~4,4,4~trifSuorobutananiido)-2,4~diffuorophen vl)~2-ch!oro~S~ ((lW,3J?)~2 _f 2-dichloro~3~{4-fSuoro~3~(triffuoromethyf)phenv ^, l)cycopropane~l~ carboMamsdo)benzamide (FI831)

Isolated as a white foam (0.073 g, 69%).

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethyS}phenyi)cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-3- (3 _f 3 _f 3-trif!uoro-2-methySpropanamido)pheny ben2:amsde (FI832)

Isolated as a white foam (0.032 g, 34%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxamido)-W-(2 _f 4-dif uoro-3- (2 _f 2 _f 3 _f 3~tetraf!uoro-3~{trifSuoromethoxy)propanamido)phenyS}b enz:amide

Isolated as a clear colorless oil (0.014 g, 13%).

2~Chloro~5~((l ? _f 3?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf}cycSopropane-l~carboxamido}~ ~(2 _f 4~dif uoro~3~ (4 _f 4 _f 4~trifluoro~2~m8thySbutanamido)phenyS}b8nz:amsde (F1S35)

Isolated as a white solid (0.044 g, 45%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cv ^, c!opr >pan8~l-carb >3 amido)~ ¥~{2,4~diff uor >-3~(2~{l~ (tnf uoromethyS}cyc 3propyi}acetar!i!do)phenv!}ben¾ar!iide (F1836)

Isolated as a white solid (0.060 g, 61%).

W-(3-(2-Ch!oro-5-(( I#?,3^)-2,2-dichSoro-3-(4-f!uoro-3- (tnf uorom8thyS}phenyi}cycfopropan8-l-carboxamido)benzamido)-2 _f 6- dif uorophenyS)-2-(tr!f!uoromethyl)tetrahydrofuran-3-carboxam!de (F1837)

Isolated as a white solid (0,042 g, 42%).

2-Chloro-5-(( l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluor i-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxamido)-W-(2 _f 4-dif uoro-3- (2 _f 2 _f 3 _f 4, ~hexaff uorobutanamido)pheny!)benzamide (F1S39)

Isolated as a white solid (0.043 g, 42%).

2~Chloro~5~((l ? _f 3l?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf )cycSopropane~l~carboxamido)~M~(2 _f 4~diff uoro~3 (4 _f 4 _f 4~trifluoro~3~oxobutanamido)phenyS)benz:amsd8 (F1S40)

Isolated as a gold solid (0.029 g, 30%). 2-ChSoro- ~(3-(2~cyano- ~propvfacetamido)~2 _f 4-diffu>ropheny!)~5~({ll?,3l?}~ 2,2-dichforo~3~(4-f!uoro-3~(tnfSuoroni ethyl }ph8nyf)cycSopropane~l- carboMamsdo)benzamide (FI841)

Isolated as a white solid (0.096 g, 64%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3-

(triffuoromethy!)phenyf)cycSopropane~l~carboxamido)~M~(3~ (2~ethoMy-/^~ propy!propanarnido}~2 _f 4~diffuorophenyS}ben-5:am!de (F1842)

Isolated as a white solid (0.056 g, 29%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3-

(trif!ujromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-( 2 _f 4-dif!uoro-3-(I- (tnfluoromethyS}cyclobutane-l-carboxamsdo)pheny!}ben2:a!T!!d e (F1849)

Isolated as a white solid (0.006 g, 6%).

f-(3-{3-Bromopropana!T!ido)-2 _i .4-difluorophenyl)-2-chloro-S

dich!oro-3-(4-fluoro-3-(trif uorometh l)pheny!}cycSopropane

carbo5amido)ben_iamide (F1851)

Isolated as a white solid (0,043 g, 44%). i¥~(3~(3~Bromobutanamido)~2 _f 4~difSuorophenyS)~2~chSoro~5-{(ll?,3l?)~2 _f 2~ dichforo~3~(4~ffuoro~3~(triffuoromethvl)ph8nyf)cycSopropane- l~

carboMamsdo)benzamide (FISS3)

Isolated as a white solid (0.054 g, 55%).

2-ChSoro-W-(3-(3-cyc!opropv!propanamido}-2 _f 4-difluorophenyS}-S-{(l^ _f 3i?}- 2,2-dich!oro-3-(4-fluoro-3-(tnfluoromethy!}pheny!)cycSopropa ne-l- carboxamsdo)ben2:am!de (FI854)

Isolated as a white solid (0,061 g, 67%).

2-Chloro-W-(3-(3-cyanopropanamsdo)-2 _i ,4-difSuoropheny -5-((i ? _? 3 ?)-2 _f 2- dich!oro-3-{4-f uoro-3-(trifluoromethyS}pheny!)cyclopropane-i- carboxamsdo)benzamide (F1855)

Isolated as a white solid (0.007 g, 8%).

2~Chloro~5~((l ? _f 3l?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethy!)phenyf)cycSopropane~l~carboxamido)~M~(3~ (5 _? 5- dimethylhe ana ido)~2 _f 4~difluoropheny!}benza ide (F1S56)

Isolated as a white solid (0.074 g, 77%). 2-ChSoro-i¥~(3-(4~cyanobutanamido)~2 _f 4~difSuorophenyl)~S~({l^ _f 3 )~2 _f 2~ dichforo~3~(4~ffuoro~3~(triffuoromethyl)ph8nyf)cycSopropane- l~

carboMamsdo)benzamide (FISS7)

Isolated as a white solid (0.060 g, 66%).

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethyS}phenyi)cycfopropane-l-carboxamido}-/y-(2,4-dif uoro-3- (4 _f S _f 5,S-tetraf!uoro-4-{tnfSuoromethoxy)pentana!T!ido)pheny !)ben2:amide (F18S8)

Isolated as a white solid (0.082 g, 74%).

i¥-(3~((E)~But-2-enamido}~2 _f 4~difSuorophenyS)~2~chSoro-5-{(ll?,3l?)~2 _f 2~ dichloro~3~(4~ffuoro~3-(triffuorom8thyS}phenyl)cyclopropane~ l~

carbGxamido}benzamide (F186S)

Isolated as a white solid (0.055 g, 47%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3-

(trif!ujromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-( 2 _f 4-dif!uoro-3-((E)- 4 _f 4,4-tnftuorobut-2-enamsdo}pheny }benza!T!ide (FI869)

Isolated as a white solid (0.096 g, 76%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(triffuorom8thyS}phenyl)cv ^, c!opr>pan8~l~carb>3amido)~¥~{2,4~diffuor>-3~ (2~ fuoroacrytarii!do}phenyt}ben¾amsde (F1870)

Isolated as a white so!id (0.064 g, 54%).

i¥~(3~(But~3~enamido}~2 _f 4~difSuorophenyl)~2~chSoro~5-{(ll?,3l?)~2 _f 2~dich! (3~(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3aniido)benza mide (F18

Isolated as a white so!id (0.076 g, 86%).

i¥-{3~(But-3~enamido}~2 _f 4~difSuoropheny!)~2~chSoro-5~((li? _? 3i?)~2 _f 2~dich!oro~3~ (3~ffuoro~5~(trifSuoromethyl)phenyf)cycSopropane~l~carbc5Mam !do}benz:amsde (F1879)

Isolated as a white solid (0.076 g, 86%).

5-C(H? _i .3i?)-3-(3-Bromo-4-f!uorophenv!)-2 _f 2-dschSorocvciopropane-l- carboxamsdo)-W-(3-(but-3-enam!do}-2 _f 4-d!fiuorophenyS)-2-chorobenEamide (F18S0)

Isolated as a white solid (0,089 g, 100%).

The following compounds were prepared in like manner to the procedure outlined in Example 7: Methyl 2-((3~(2~ch!oro~5-((lW _f 3J?)-2,2-dichloro~3~{4-f!uoro~3~

(triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)ben¾a mido)~2 _f 6~ dif uoropheny!)amsno}-2-oxoacetate (F1753)

Isolated as a white so!id (0.064 g, 72%).

The following compounds were prepared In like manner to the procedure outlined In Example 9 ;

2-Ch!oro-S-((l^,3^)-2,2-dschSoro-3-(4-f!uoro-3-

(trif!ujromethvt}phenv!}cv'cSopropane-l-carboxamido}-i¥- (2 _f 4-dif!uoro-3- ((3 _f 3,3-tr!fluoropripv!)su!fonamido}phen¾f benza!Ti!de (FI350)

Isolated as a clear colorless oil (0,019 g, 14%),

2~ChSoro-5-{(li? _i 3i?)~2 _f 2~dich!oro~3~(4~fSuoro~3~

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~ (3~(((2,2~

dichforocyc!opropyf)methyS}sufonamsdo)~2,4~dsfluoroph8nyf )benzamide (FI361)

Isolated as a white foam (0.028 g, 20%).

The following compounds were prepared In like manner to the procedure outlined In Example JO:

trams-tert-Butyl (4-(((4-(2-chSoro-5-(2 _f 2-dschoro-3-(3,5- dich!oropheny cyciopropane-i-carboxamido)ben2:amsdi)-3- methylphenyS)ammo)methy pbenyl)carbamate (F1348)

Isolated as a yellow oil (0.109 g, 76%).

The following compounds were prepared In like manner to the procedure outlined In Example 12:

frans-l-Ch oro-B-il _f Z-d!ch!oro-S-CS^B-dich!oropheny cyc!opropane-I- carboxamsdo)-W-(4-({4-hvdroxyben¾v!)amino)-2-meth¾f!phenv! }ben2:a!T!!de

(FI353)

Isolated as a pale yellow foam (0.057 g, 69%).

The following compounds were prepared in like manner to the procedure outlined in Example 13:

W-{3-Amino-2,6-d!f uorophenvt}-2-ch oro-5-((lW _f 3W}-2,2-dich!oro-3-(3,4 _f S- trichSoropheny!)cv'cSopropane-l-carboxamido)-3-f uorobenzamide (FI337)

Isolated as a white solid (0, 166 g, 80%).

W-{3-Amino-2,6-d!f uorophenvt)-2-ch oro-5-((lW _f 3W}-2,2-dich!oro-3-(3,4- dich!oropheny cyc!opropane-i-carboxamidol-S-fiuorobenzamide (FI33S)

Isolated as an off-white powder (0.154 g, 73%).

-{3-Amino-2,6-d!f uorophenvt)-2-ch oro-5-((lW _f 3W}-2,2-dich!oro-3-(4-f uoro- -(trifiuoromethy!)phenvOcyc 3propane-l-carboMamsdo}-3-f!u 3robenzam!de (F1339)

Isolated as a light yellow solid (0.153 g, 74%).

frans~M~(4~((4~Aminobenzy!)amino}~2~methySpheny!)~2~chfor o~S~(2,2~dichforo~ 3~{3,5-dichforopheny!)cycfopropane~l~carboxamsdo)benzaniide (F1349)

Isolated as a yellow solid (0.018 g, 26%),

frans-M-(3-Ammo-4-chSoropheny!)-2-chloro-S-{2 _f 2-dsch oro-3-(3-ch!oro-4- ^)cyciopropane-l-carboxamsdo)ben2:am!de (FI365)

Isolated as a white solid (0.143 g, 84%).

frans~i¥~(4~Amsno~3 _f 5~dichfc5rophenyS}~2~chSoro~5~(2 _f 2~dichloro~3~{3~chSoro- ffuoropheny!)cycfopropane~l~carboxamsdo)ben2amide (F1367)

Isolated as a white foam (0.170 g, 70%).

£r3ns-W-(4-Ammo-3-cyanGphenyi)-2-cW

ffuorophenyS}cyclopropane-l~carbo5 amido}ben.5:am!de (F1387)

Isolated as a white solid (0.111 g, 64%).

fra«s~ ¥~(4~Amsno~3~{triffuoromethyf )phenyl)~2-ch!oro~S~{2,2~dichf >ro~3~(3- ch!oro-4-f!uorophenyS)cyciopropane-l-carboxamido}ben2:amsde (FI390)

Isolated as a white foam (0.191 g, 67%).

~(3-Amino-2,6-diffuor >phenv ^, !)-2~chforo~S~{{lJ? _f 3^)-2,2-dichforo~3~(4-ff uor >- -(trifluoromethyl)phenyl)cyclopropane-l-

Isolated as a tan solid (0.600 g, 98%).

-{5-Amino-2,4-d!f uorophenyt)-2-ch oro-E

-fluorophenyl }cydoprGpane-l-carbGxam id©)

Isolated as a light-tan solid (0.276 g, 83%).

W-{5-Amino-2 _f 4-dif uorophenyS)-2-ch oro-5-({i ? _? 3 ?}-2 _f 2-dich!oro-3-{3 _? 4- dichlorophenyS)cyclopropane-l~carboxarnido}~3~ffuorobenzamid e (F1396]

Isolated as a tan solid (0.319 g, 95%).

i¥-(5~Amino~2 _f 4~dif uorophenyS)~2~chforo-5~({ l ,3l?}~2 _f 2~dichloro~3-(3 _f 4,5- !orophenyS)cyc!opropan8~l~carbo3 an

Isolated as a !ight-tan solid (0.302 g, 92%).

J¥-(S-Amino-2,4-dif!uorophenyS)-2-ch!oro-5-({l#?,3 ?}-2 _f 2-dichi3ro-3-(4-f!u3ro- 3-Ctrif!uoromethv }phenyS}c¥clopropane-I-carboxamsdo)-3-fiuoroben2:a!T!!de (FI398)

Isolated as a tan solid (0.311 g, 92%).

W~{5-Amino~2,4-difluoropheny!)-2~chforo~S~((l^ _f 3^)-2,2-dichforo~3~{3 _f S~ dichforopheny!)cycfopropane~l~carboxamido)~3-fluorobera:am!d e (F1399)

Isolated as a light-tan solid (0.301 g, 95%).

M-(3-Amino-4-meth¥!pheny )-2-ch!oro-5-((I^,3 ?}-2 _f 2-d!chSori-3-C4-fluoro-3- (tnfluoromethyS}pheny!)cvc!opropane-I-carboxamido)benza!Ti!d e (FI413)

Isolated as a white solid (0.143 g, 65%).

M-(3-Amino-2 _? 6-d!fluorophenv -2-chloro-S-(Ci^ _f 3^)-2 _? 2-dich!oro-3-(3 _f 4- dich!orophen¥ cyciopropane-i-carboxa!T!ido)-3-meth¥tben2:a!T!ide (FI426)

Isolated as a white powder (0.176 g, 76%).

Isolated as an off-white solid (0.194 g, 82%).

Amino~2 _f 6~difuorophenyS)~2~chforo-5~({l ,3l?}~ 2~dichloro~3~(4~ff !uoromethv}phenyt}cyc!opropane-l- 3-methy!benzamid

Isolated as a tan powder (0.163 g, 70%).

W~{3-Amino~2,4-difluoropheny!)-2~chforo~S~((l^ _f 3^)-2,2-dichforo~3~{3 _f 4~ dichforopheny!)cycfopropane~l~carboxamido)~3~methy!benzamide (F1446]

Isolated as an off-white solid (0.167 g, 66%).

~(3-Amino-2~methyf h8nyf)~2-chforo~S~({l^ _f 3 )~2 _f 2~dichSoro-3-{4~fluoro- (tnfuoromethyS}phenyi}cycfopropane-l-carboxamido)benzamide (FI44S)

Isolated as an off-white solid (0.193 g, 78%).

J¥-(3-Amino-2,4-dif!uorophenyS)-2-ch!oro-5-({ l#?,3 ?}-2 _f 2-dichi 3ro-3-(4-f! u 3ro- 3-Ctrif!uoromethv }phenyS}c¥clopropane-I-carboxamsdo)-3-methySbenEamide (FI458)

Isolated as an off-white powder (0.154 g, 64%).

~(3-Amino-2,4-diffuoropheny!)-5~{(II?,JI?)~2 _f 2~dichforo~3~(3,4- dichforopheny!)cycfopropane~l~carboxamido)~2-fluorobera:am!d e (F1459)

Isolated as a light yellow foam (0.382 g, 80%) .

~(5-Amino-2,4-diffuoropheny!)-2~chforo~S~({lJ? _f 3^)-2,2-dichforo~3~(3 _f 4~ dichforopheny!)cycfopropane~l~carboxamido)~3-methy!benzamide (F1470)

Isolated as an off-white powder (0.155 g, 61%).

W~{5-Amino~2,4-difluoropheny!)-2~chforo~S~({l^ _f 3^)-2,2-dichforo~3~(4-ffuoro~ 3~{trifluoromethyf)phenyS}cycfopropane-l~carbo5amido)~3~meth ySbeniamide (F1478)

Isolated as an off-white powder (0.185 g, 70%).

W-(5-Amino-2,4-d!fuorophenyt)-5-((J ?, JU}-2 _f 2-dschoro-3-(3,4- dich!orophenyS)cyc!opropane-i-carboxamido)-2-f!uoroben2:amid e (FI490)

Isolated as a iight brown foam (0.387 g, 89%).

2-ChSoro-5-((I ? _J ,3?}-2 _f 2-dschtoro-3-(3,4-dich!oropheny)cyc!opropane carboxamsdo)-i¥-(2 _f 4-d!fiuoro-3-(methylarn!no)pheny ben2:amsde (Fl

Isolated as a yellow foam (0.870 g, 97%).

M-(5-Amino-2 _? 4-difluorophenv -2-c loro-S-(Ci _{1 f} 3^)-2 _? 2-dich!oro-3-(4-fluiro- 3~{trifluoromethyf)phenyS}cycfopropane-l~carbo5amido)ben-iam ide (F1566)

Isolated as a tan solid (0.210 g, 89%).

frans~M~(3~Amsno~2 _f 4~difSuorophenyl)~2~chloro-5~{2 _f 2~dich!oro~3~(4~fSuoro~3~ iodophenyS)cyclopropane-l~carbo amido}b8nz:amsde (F1622)

Isolated as a tan foam (0.108 g, 94%),

W~{3-Amino~2,4-difluoropheny!)-2~chforo~S~((J^3^)-2,2-dichfo ro~3~{4-chforo~ ~{trifluoromethyf)phenyS}cycfopropane-l~carbo5amido)ben.iami de (F1631)

Isolated as a white solid (0,860 g, 85%). [5~Amino-2,4~diffuoro-3~methylph8nvf}~2 toro~5~((lJ? _f 3l?)~2 _f 2~d!ch!QrG-3~ -ffuoro~3-(trif!uoromethyS}phenyl)cvc!oprop ane~l~carbo aniido)benzamide

Isolated as a white solid (0.151 g, 79%).

i¥~(3~Amino~6~bromo~2~methyf phenyl )~2~chloro~5~((lH _f 3J?)-2 _f 2~dich f!uoro-3-(tnfluoromethyS}phenyi}cyc!opropane-l-carboxam!do)b e

Isolated as a white solid (0.039 g, 75%).

J¥-(3-Amino-2,4-dif!uorophenyS)-2-ch!oro-5-({ l#?,3 ?}-2 _f 2-dichi 3ro-3-(3-f!u 3ro- !uoromethy )phenyt)cyc!opropane-l-carboxamsd 3}benxar!i!de

Isolated as a white solid (0.784 g, 87%).

W~{3-Amino~2,4-difluoropheny!)-5~({ll? _? 3i?)~3~{3~bromo-4~f!uorophenyf )~2,2 dichforocyc!opropane~l~carbo arnido)~2~chlorobenzaniide (F1713)

Isolated as a white solid (0.308 g, 85%).

^~(5-Amino-2,3,4~triff uorophenyS}~2~chSoro-5~({ l ,:

luoro~3~(trifSuoromethyl)ph8nyf )cycSopropane~l~ca

Isolated as a white foam (0.188 g, 91%).

2-€ΗΙθΓθ-5-((1^,3^)-2,2-€ίεΗ§θΓθ-3-(4-Αυο Γθ-3-

(triffuoromethy!)phenvf)cycSopropane~l~carboxamido)~M~(3~ (ethyf mino)~2,4~ difluoropheny!}benzamide (F1762)

Isolated as a white foam (0.424 g, 87%).

W~{3-Amino~2,4-difluoropheny!)-2~chforo~S~({J^3^)-2,2-dichfo ro~3~(4-ffuoro~ 3~{trifluoromethyf)phenyS}cycfopropane-l~carbo5amido)~i¥"me thyfben.iam!de (F1785)

Isolated as a brown foam (0,565 g, 98%).

frans~i¥~(3~Amsno~2 _f 4~difSuorophenyl)~5~{3-(3 _f 5~bis(trifSuoromethyf)phenyS}~ -dichforocyc!opropane~l~carboxamido)~2~chlorobenzamide (F1791)

Isolated as a white foam (1.27 g, 98%).

2-ChSoro-5-{(Ii? _f 3i?)-2,,2-dsch!oro-3-(4-fSuoro-3-

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~i¥~ (2,4~diffuoro~3~ (prop~2~yn~l~yf m!no)phenyS}ben-5:amsde (F1807)

Isolated as an amber oil (0.215 g, 72%) .

2-€ΗΙθΓθ-5-(( 1^,3^)-2,2-€ίεΗ§θΓθ-3-(4-ΑυοΓθ-3-

(triffuoromethy! )phenvf )cycSopropane~l~carboxamido)~M~(2 _f 4~€liff uoro~3~({2- ffuoroethyf )amino}phenyS}ben_iam!de (F1B26)

Isolated as a gold oil (0.147 g, 68%) .

loro~5~(( l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3- luoromethyt )pheny!}cv'cSopropane-l-carboxamido}-i¥-(2 _f 4-dif!uoro-3- (propyiamino)phenyt)benzamide (F1838)

Isolated as a clear, colorless oil (0.331 g, 66%) .

The following compounds were prepared In like manner to the procedure outlined in

ino-2,6-dif uorophenyt)-5 {{lR _f JU}-2 _f 2-dsch oro-3-(3,4,5- !orophenyl )cydopropane-I-ca rboxam!do)-2 _? 3-dif!uorobenzam!

Isolated as a white foam (0.274 g, 81%) .

The following compounds were prepared In like manner to the procedure outlined in ~(3-Amino-4~bromo-2~methyf h8nyf )~2-chf >ro~S~({l^ _f 3 )~2 _f 2~dichSoro-3-{4~ ffuoro~3~(trifSuoromethvl)ph8nyf )cycSopropane~l~carbo amido)benzamid8

(FI690)

Isolated as a white foam (0.090 g, 69%).

The following compounds were prepared in like manner to the procedure outlined in Example 18:

5-{{1^3^)-3-{3-Bromo-4-fSuorophenv!)-2 _i ,2-dsch!oroc¾ ^r c!opropane-I- carboxamsdo)-2-chloro-Af-{3-(2 _f 2-d!fiuoroacetam!do)-2 _f 4- diff uorophenyS)ben_iam!de (F1410)

Isolated as a white soiid (0.059 g, 35%).

5-{{1^3^)-3-{3-Bromo-4-chlorophenyS}-2 _? 2-dich!orocvcSopropane-I- carboxamsdo)-2~chloro~Af-{3~{2 _J ,2~diffuoroacetamido)~2 _f 4~

dif uorophenyS}b8nramide (F1411)

Isolated as a white solid (0.053 g, 32%),

The following compounds were prepared in like manner to the procedure outlined in Exampie 20 :

tert-Butyl /¥~£-ert-buto ycarbonyf-i¥~[5-[[2~chforo-5~[[(l^ _f 3^}-2,2~dschSoro-3~ (3~chloro~4~ff uoro-phenyl)cyclopropanecarbonyl]amino]~3~fluoro~

benTOyn3!T!ino]-2 _i .4-dsfSuoro-pheny!]carbamat8 (F1379)

Isolated as a white so!id (0.429 g, 79%).

fert-Buty! f-terf-butoxvcarbonv -W-[5-[[2-ch!oro-5-[[(IW _f 3^}-2,2-dschSoro-3- (3 _? 4-dich!orophenvS)cvc!opropanecarbonv!]am!no]-3-fluoro- benz:oy ]a!T!!no]- 2 _f 4-dif!uQro-phenyl!]carbamate (FI380)

Isolated as a white solid (0,402 g, 69%).

ferf-Buty /¥-fert-butoxycarbonyhi¥-[5-[[2-ch oro-5-[[Cl ?,3 ?}-2 _f 2-dschtoro-3- (3 _f 4 _f 5-trich!orophenyS)cvc!opropanecarbonyS]ammo]-3-fluoro- benz:oyi]a!T!!no] 2,4-diff uG -phenynearbamate (Fi38I)

Isolated as a white solid (0,425 g, 70%).

ferf-Butyf Af-fert~butoxycarbonyf~i¥-[5~[[2~chforo~S~[C{ll? _? 3i?)~2 _f 2~dich!oro~3- [4~ffuoro~3-(trif!uoromethyS}phenyl]cyc!opropanecarbonyl3ami no]~3~f!uoro- benzoyS]amino]~2,4~dsf!uoro~phenyS]carbamate (F1382)

Isolated as a white so!id (0.355 g, 62%).

fert-Buty! f-terf-butoxvcarbonv -W-[5-[[2-ch!oro-5-[[(IW _f 3^}-2,2-dschSoro-3- (3 _? S-dich!orophenvS)cvc!opropanecarbonv!]am!no]-3-fluoro- benz:oy ]a!T!!no]- 2 _f 4-dif!uQ -phenyl!]carbamate (FI383)

Isolated as a white so!id (0.266 g, 47%).

3-{{ l^ _i 3^)-2 _i .2-Dich!oro-3-(3 _i .4-dich oropheny cvciopropane-l-carboxamsdo) i¥-{3~{2 _J ,2~dif!uoroacetamido}~2 _f 4~diff uc5rophenyS}ben-5:amk

Isolated as a white foam (0.123 g, 56%).

frans-S-{3-(3- romo-S-chSorophenv'l)-2 _f 2-dsch oTOcyclopr ipane-l- carboxamsdo)-2~chloro~Af~{3~(2 _J ,2~diffuoroacet

diff uorophenyS)ben_iam!de (F1618)

Isolated as a white foam (0.077 g, 76%). The title compound was prepared from trans-3-(3-bromo-5-chlorophenyl)-2,2-dichlorocyclopropane-l- carboxylic acid which was prepared via methods described in U.S. Patent Application Pubiication US20160304522A1 (C215).

trans-tert-Butyl f-[3-[[5-[[3-(3-bromo-4,5-dichSoropheny!}-2,2- dich!orocvcfopropanecarbonvi]amino]-2-ch!orobenzov ]amino]-2 _f 6- dif uorophenyS]-W-fert-butoxycarbony -carbamate (Fi6i9)

Isoiated as a white soiid (0.139 g, 88%).

trans-tert-Butyl W-i-erf-butoxycarbonvl-/¾'-[3-[[2-chSor i-S-[[2 _f 2-c !chSor i- fluoTO-3-sodophenv!)cyc opropanecarbonvl]amsn i]benzov!]am!no]-2 _f 6- diff uorophenyl]carbamate (F1620)

Isoiated as a white soiid (0.155 g, 97%).

ferf-Butyf /¥~fert-butoxycarbonyf-W~[3-[[2~chforo~5~[C{l^ _f 3 ?)-2 _i 2~dschSoro~3~

(triffuoromethy!)phenyf ]cycSopropanecarbonyf ]amino]benTOyl]amino]~2 _f 6~

Isoiated as a colorless glass (0.87 g, 99%). ferf-Butyf /¥-fert~butoxycarbonyf~i¥-[3~[[2~chforo~S~[C(ll?,3l?)~2 _f 2~dich!oro~3~ [3~(triffuoromethv!)phenvf]cycSopropanecarbonvf]anii no] benzoyl ]amino]~2 _f 6~

Isolated as a white foam (1.35 g, 91%).

2~Chloro~5~((J ? _jr 3?)-2 _i 2~dschSoro~3~i3 _f 4 _f 5~trif!uorophenyl)cycfopropane~l carboxamsdo}- ~(2 _f 4~d!fiuoropheny!)benzamsde (F1693)

Isolated as an off-white solid (0.500 g _f 35%).2~Chforo~5~((JS,3S}~2 _f 2~ dichioro-3-(3,4,5-trif!uoropheny!)cycSopropane-l-carboxamido )-/¥-(2j4- dif!uorophenyS}benzamide (FI749)

Isolated as an off-white solid (0.360 g, 46%),

2~ChSoro-5-{(Ji?,3i?)~2 _f 2~dich!oro~3~(3,4-diffuorophenyl)cycfopropane~l~ carbo5amido)~i¥-(2,4~difluoropheny!)benzamide (F175Q)

Isolated as an off-white solid (0.500 g, 50%).

2~ChSoro-5-{(JS3S)-2 _? 2-dichforo~3~(3 _J ,4~diffuorophenyf}cyclopropane-l~ carbo a ido)~i¥-(2 _f 4-dsfluGropheny!)benza ide (F1751)

Isolated as a pa!e yellow solid (0.500 g, 50%).

ferf-Butyf Af-[3~[[5~[[{l^ _f 3 ?)-3-{3~bromo~4~ff uoro-pheny!)~2 _f 2~dich!oro~ cyclopropanecarbonyS]amino]-2~chloro~benzoyf ]arnino]~2 _f 6~difSuoro~phenyl ]- ~fert-but03cycarbony carbamate (F1776)

Isolated as a white solid (1.2 g, 93%),

ferf-Butyf /¥-fert~butoxycarbonyf~i¥-[3~[[2~chforo~S~[C(ll?,3l?)~2 _f 2~dich!oro~3~ [4-f!uoro-3-(trifluoromethyS}phenyi]cycfopropanecarbonyi]ami no]benzoyn~ r!iethy!-amino]-2 _f 6-dif! u 3ro-phenyt)carbamate (F1784)

Isolated as a white foam (0.730 g, 82%).

trans~terf~Butyl ¥~[3~[[5-[[3-[3 _f 5-bis{trifSuoromethyf )phenyS]~2 _f 2~dichloro~ cycfopropanecarbony!]amino]~2~chSoro~benz:oyf ]amino]~2,6~dsfluoro~phenyS]~ JV-fert-butoxycarbonyhcarbamate (F1786)

Isolated as a white foam (1.7 g, 92%). The tit!e compound was prepared from trans-3-(3,5-bis(trifluoromethyl) phenyl )-2,2-dichlorocyclopropanecarboxylic acid which was prepared via methods described in U.S. Patent Application Publication

US20160304522A1 (C8),

frans-ferf-Butyl f-[3-[[S-[[3-[3-bromo-5-(tnf uoromethv!)phenv!]-2 _f 2- dich!oro-cvclopropanecarbonvS]am!no]-2-ch!oro-benzovl]amsno] -2 _i ,6-dif!uoro- phenvl]™ ~ferf-but03cycarbonyf-carbamate (F17S7)

Isolated as a white foam (1.7 g. 94%).

ferf-Butyf /¥~fert-butoxycarbonyf-W~[3-[[2~chforo~5~[C{l^ _f 3 ?)-2 _i 2~dschSoro~3~

(triffuoromethy!)phenyf ]cycSopropanecarbonyf ]amino]benTOyl]amino]~2 _f 6~

Isolated as a white foam (1.9 g, 94%).

-2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane-l~ carbo3 amido)~i¥-(2~(2 _f 2 _f 2~triffuoroacetamido)8thyS)benz:amsde (F2066]

Isolated as a white solid (0,075 g, 24%).

frans-W-(3-Acetam!dopropy -2-chloro-S-(2 _? 2-dichloro-3-{3 _f S- dich!orophenyS)cyc!opropane-i-carboxamido)ben¾amsde (F2067)

Isolated as a white solid (0,100 g, 34%).

■¥~{4~Acetamidobuty!)-2~chforo~5-(2,2- Jichforopheny!)cycfopropane~l~carboxamido)ben2amide

Isolated as a white solid (0,140 g, 47%).

frans-/y-(5-Acetarii!dopenty!}-2-ch!oro-5-{2,2-dich!oro-3 -(3,5- dich!oropheny cyc!opropane-i-carboxamidolbenxamsde (F20C

Isolated as a white solid (0.100 g, 33%).

frans~2-Chforo~5-(2,2~dichloro~3~(3 _? 5-dichforopheny!)cycfopropani carboxamsdo)-i¥~(3-(methyfam!no)-3~oxopropyf}benzaniide (F207C

Isolated as a white solid (0.090 g, 32%).

-2-ChSoro-5-(2 _f 2-dich jro-3-(3,5-d!ch!

carboxamsd j}-W-(2,2-dif!u3ropropyS)ben2:amsde (F2075]

Isolated as an off-white solid (0.150 g, 60%),

fraiis-Ethyl 3~(2~chloro~5-(2,2-dich!oro~3~{3,5-dichforopheny!)cycfopropa ne~l~ carboMamsdo)benzamido)-2,2-dif!u 3ropropanoate (F2076)

Isolated as a pale yellow solid (0.120 g, 46%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f S-dich iropheny cyci ipropane-l- carboxamsdo)-i ~(2 _f 2~diff uc5ro~2-phenySethyS}ben-5:amsde (F2077)

Isolated as an off-white solid (0.150 g, 57%).

frans-l-Ch oro-B-i _f Z-d!ch!oro-S-CS^B-dich!oropheny cyc!opropane-I- carboxamsd j -W-(2-oxo-2-{2,2,2-tnfSuoroethytam!no)ethyS)ben2:amsde (F207S)

Isolated as an off-white solid (0.063 g, 19%),

frans~2~Chforo~5~((l ?,3 ?)~2 _f 2~dichSoro-3~{3 _f 5~dichforophenyS}cycfopropane~l- carbo5 amido)~i¥-(3~oxo-3~{2 _f 2,2~tnf!uoroethySarnino}propyS}ben.iam!de (F2079)

Isolated as an off-white solid (0.140 g, 39%),

■2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS

carboMamsdo}-i¥-(4-oxo-4-(2 _i .2,2-tnftuoroethv'Samino)butv

Isolated as an off-white solid (0.089 g, 26%).

frans-2-Chloro-S-(2 _? 2-d!chloro-3-{3 _f S-dich iropheny cyci ipro carboxamsdo)-i¥~(2-03co~2~(3 _? 3 _f 3~tnfSuoropropylamino)ethyl)b

Isolated as an off-white solid (0.075 g, 19%).

■2-Ch oro-5-(2,2-d!ch!oro-3-{3,5-dicb!orophenyt]

carboxamsdo)-W-(2-(2 _f 2 _? 2-tr!flu iroaceta!T!ido)ethyS)ben¾amsde (F20S2]

Isolated as an off-white solid (0.060 g, 32%).

frans~2~Chforo~5~(2 _f 2~dichSoro-3~{3 _f 5~dichforophenyS}cyclopropane-l- carbo3 amido)~i¥~(2 _f 2~difluorobutyS)benzamsd8 (F2086)

Isolated as an off-white solid (0.050 g, 28%),

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane-l~ carbo3 amsdo)-i¥-(2,2-d!fiuoropropyf )benxamsde (F20S7)

Isolated as an off-white solid (0.100 g, 60%).

trans~2~Chforo~5-(2,2-dichloro~3~{3,5-dichforopheny!)cycf opropane~l~ carboxamsdo}-i¥~(2 _f 2~diff uorobuty!)-3~fSuorob8n :am!de (F208S}

Isolated as an off-white solid (0.100 g, 21%),

fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cycloprop carboMamsdo}-3-f!uoro-i¥-(2-oxopropvi}benzamide (F2090)

Isolated as an off-white solid (0.100 g _f 18%).

irans-l-Ch oro-B-ilf S-dichloro-S-CS^-dich!orophenvOcyciopropane-I- carboxamsdo)-W-(2 _? 2-difiuoro-2-phenvlethv!)-3-fSuoroben¾am!de (F209I)

Isolated as an off-white solid (0.090 g, 13%),

fraiis~2~Chforo~S~(2 _f 2~d!ch!oro-3-{3 _f S~dichforopheny!)cv'clopropane-l~ carboMamsdo)-i¥-(3-oxo-3-(3 _f 3 -tnffuoropropv!amsn >)propy!)benzamide (F2092)

Isolated as an off-white solid (0.125 g, 31%).

frans~2-Chforo~5-(2,2~dichloro~3~(3 _? 5- dichlorophenyS)cyclopropanecarboxamido)~ ~{4~oxo~4~(3 _J ,3 _f 3~

trifiuoropropyfamino)buty!)benzamsde (F2093)

Isolated as a pale pink solid (0.130 g, 31%). fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane-l~ carbo3 amido)~i¥-(3~(2 _f 2 _f 2~triffuoroacetamido)propvl}benzaniide (F2094)

Isolated as an off-white solid (0.171 g, 42%).

trans~2~Chforo~5-(2,2-dichloro~3~{3,5-dichforopheny!)cycf opropane~l~ carboxamsdo)-i¥~(2-(2 _f 2,3 _f 3 _f 3~pentafluoropropanamsdo)8thyS}b8n :am!de (F2096)

Isolated as an off-white solid (0.170 g, 40%),

frans-2-Ch oro-5-(2 _f 2-d!chSoro-3-C3 _? 5-dichlorophenyS)cyc!opropane-I- carbo5 amido)~i¥-(3~(2 _f 2 _f 3,3 _? 3-pentafSuoropropanamido)propyl)ben-iarnide (F2097)

Isolated as a pale blue solid (0.131 g, 30%). fraiis~2~Chforo~S~(2 _f 2~dichSoro-3-{3 _f S~dichforophenyS)cyclopropane-l~ carbo3 amido)~i¥-(4~(2 _f 2 _f 3 _f 3 _/ 3-pentafSuoropropanamido}butvf }benzaniide

Isolated as an off-white soiid (0.450 g, 48%) . The title compound was prepared from 5-amino-2-chloro-/V-(2,2,2-trifluoroethyl)benzamide, which was prepared using methods described in U .S. Patent Application Publication 20160302418A1 (C70) .

2~Chloro~5~((JS,3S)~2 _f 2~dichloro~3~(3 _f 4~d!fluorophenyf )cycfopropane~l~ carboxamsdo)-i¥~( ~triffuoroethyf )benzamide (F2100)

Isolated as an off-white solid (0.450 g _f 48%) . The title compound was prepared from 5-amino-2-chloro-/V-(2,2,2-trifluoroethyl)benzamide, which was prepared using methods described in U .S. Patent Application Pubiication 20160302418A1 (C70) ,

The following compounds were prepared in like manner to the procedure outlined in Example 21 :

frans~i¥~(3~Amsno~2 _f 4~difSuorophenyl)~5~{3-(4~brornophenyf )~2,2- dichforocyc!opropane~l~carboxamido)~2~chlorobenzamide (F1591)

Isolated as a white foam (0.108 g, 36%).

frans-W-(3-Ammo-2 _i .4-dsfluorophenv!)-2-ch!oro-5-(2 _f 2-dschSoro-3- ieny!)cydopropane-l-carboxamido}benzam!de (F1592)

Isolated as a white foam (0.092 g, 27%),

- f-(3-Ammo-2 _? 4-dsfSuoropheny!)-2-ch!oro-5-{2 _i ,2-dsch!oro-3- chloropheny cvclopropane-i-carb jxam!do)benEamsde (F1593)

Isolated as a white foam (0.162 g, 50%),

f-(3-Ammo-2 _? 4-dsfSuoropheny!)-5-(3-(3-bromopheny -2 _? 2- dich orocyc!opropane~l~carboxamido)~2~chlorobenzamide (F1594

Isolated as a white foam (0.103 g, 34%).

- f-(3-Ammo-2 _? 4-dsfSuoropheny!)-2-ch!oro-5-{2 _i ,2-dsch!oro-3- chlorophenyf )cyc!opropane~l~carboxamido)beniamide (F1595)

Isolated as a white foam (0.152 g, 4/%). fraiis~ ¥~{3~Amsno~2 _f 4~difSuorophenyl)~2~chloro~5~(2 _f 2~dich!oro~3~{3~ ffuorophenv!)cycfopropane~l~carboxamsdo)ben2amide (F1596)

Isolated as a white foam (0.199 g, 59%).

The following compounds were prepared in like manner to the procedure outlined in Example 22 :

frans-2-Ch!oro-5-(2,2-dichSoro-3-(3 _f 5-dich 3rophenyS)cyci 3propane-l- carbo3 amsdo)-i¥- -d!ch!oro-4-hvdroKypheny!)benzamide (F1360)

Isolated as a tan foam (0.096 g, 93%).

ferf-Butyf {3~{2-chloro~5~((l ? _f 3 ?)-2 _i 2~dichSoro-3~i3 _f 4~

dichlorophenyS)cyclopropane-l~carboxarnido}~3~methySben-i arnido}~2 _f 4~ diff uorophenyS)carbamate (F1420)

Isolated as a tan foam (0.270 g _f 91%).

fert-Buty! (3-C2-ch!oro-S-{(l^,3^)-2,2-dichSoro-3-(3 _f 4 _f 5- tr!chSorophenv'l)cycSopropane-l-carboxam!do}-3-methv'!ben¾a msdo)-2 _f 4- difluorophenyl)carbamate (F142I)

Isolated as an off-white solid (0.274 g, 94%).

ferf-Butyf (3-(2~chSoro-5-{(ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethv'S}phenyi}cvcfopropane-l-carboxamido}-3-methviben¾ amido}- 2,4-diffuoropheny!)carbamate (F142 )

Isolated as an off-white solid (0.271 g, 100%).

ferf-Butyf /¥~fert-butoxycarbonyf-W~[3-[[2~chforo~5~[C{l^ _f 3 ?)-2 _i 2~dschSoro~3~ (3 _f 4~dichSorophenyl)cycSopropanecarbonyf lamino3"3~methyl-ben-5:oyS]amino]- 2 _f 6~difSuo ~pheny!]carbamate (F1423)

Isolated as an off-white solid (0,320 g, 100%),

ferf-Buty W-£ ^, ert-butoxycarbonyhi¥-[3-[[2-ch oro-5-[[{ l^ _i 3^)-2 _f 2-dschS (3 _f 4 _f 5-trich!orophenyS)cyc!opropanecarbonyS]ammo]-3-methy!- benzoy!]a ~2 _f 6~difSuoro~phenyl]carbamate (F1424)

Isolated as an off-white solid (0.325 g, 98%).

ferf-Butyf Af-fert~butoxycarbonyf~i¥-[3~[[2~chforo~S~[C{ll? _? 3i?)~2 _f 2~dich!oro~3~ [4~ffuoro~3-(trif!uoromethyS}phenyl]cyc!opropanecarbonyl 3amino]~3~methyS~ nzoyl ]amino]~2,6~dsf!uoro~phenyS]carbamate (F142S)

Isolated as an off-white solid (0,315 g, 100%),

ferf-Buty W-£ ^, ert-butox¾ ^r carbon¾fhi¥-[S-[[2-ch oro-5-[[{ l^ _i 3^)-2 _f 2-c schSoro-3- (3 _f 4~d!chSorophenvl)cycSopropanecarbon¾ff lamino3"3~methyl-ben-5:oyS]amino]- 2 _f 4~difSuo ~pheny!]carbamate (F14S5)

Isolated as an off-white solid (0,305 g, 100%)

ferf-Butyf /¥-fert-butoxycarbonyhi¥-[5-[[2-ch oro-5-[[C l ?,3 ?}-2 _f 2-dschtoro-3- (3,4,5-trichlorophenyl)cyclopropanecarbonyl]amino]-3-methyl- benzoyna -2 _i 4-dsfSuoro-phenyl]carbamate (F14S6)

Isolated as an off-white solid (0.335 g, 100%)

fert-Butyl Af-tert-butoxycarbony -W-[5-[[2-chloro-S-[[(I _f 3 )-2 _i ,2-dsch!oro-3- [4~ffuoro~3-(trif!uoromethyS)phenyl]cyc!opropanecarbonyl3ami no]~3~methyS~ benTOyS]amino]~2 _? 4-dsf!uoro~phenyS]carbamate (F1457)

Isolated as an off-white solid (0,352 g, 100%),

The following compounds were prepared in like manner to the procedure outlined in Exampie 25:

2~Chloro~5~((l ? _f 3?)-2 _i 2~dschSoro~3~i4~fluoro-3~

(triffuoromethv!)phenvf}cycSopropane-l~carboxamido)~ ~(3~{2,2~dif!uoro-M~ methySacetamsdo)-2,4~dsfluoroph8nyf)benzamide (F1386)

Isolated as a white foam (0.122 g, 79%).

ferf~Butyf~M~((fert~butoxy}carbony!)~^~[5-[[5-[[(l ?,3l?}~2 _f 2~dich!c5ro~3-(3,4~ dichforopheny!)cycfopropanecarb>ny!]amin>]~2~ffuoro~b8 n :oyS]amsno]~2 _f 4~ diffuoro-phenyS]carbamate (F1467)

Isolated as a white solid (0.590 g, 68%).

W-{3-Acetamsdo-2 _? 6-difluorophenyl)-2-chloro-S-({l^ _i 3^)-2 _f 2-dsch oro-3-(3 _f 4 _i ,5- trich!orophenyS)cyc!opropane~l-carbo amido)ben-iarnide (F1S1S)

Isolated as a white solid (0.100 g, 73%). 2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4,S~trichlorophenyf )cyclopropane-l- carbo¾amido)~i¥~(2 _f 6~difluoro~3~(2 _f 2 _f 2~tnflu >roacetamido)phenv ^, l)benzamide

Isolated as a white solid (0.116 g, 85%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSor >-3~(3 _f 4 _f 5-trichf >rophenyf )cvcfopropane~l~ carboxamsdo)-i¥~(5-(2 _f 2-diffuoroacetamido)~2,4-dif!uorophenvl}benzaniide (F1518)

Isolated as a tan solid (0.114 g, 79%).

2-ChSoro-5-{(Ii? _f 3i?)-2,2-dsch!oro-3-(3 _? 4 _f S-trich!oropheny )c¾ ^r c!op!Opane-I- carboxamido)~ -(2,4~difluoro~5~(2 _f 2 _f 2~trifluoroacetamido)phenyl)benzamide (F1S19)

Isolated as a white solid (0,118 g, 79%).

~(3-Acetamsdo~2 _f 4~difSuorophenyS)~2~chSoro-5-{(ll?,3l?)~2 _f 2~dich

Isolated as a white solid (0.119 g, 87%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(3 _f 4 _i ,5-trich!orophen¥l)cvciopropane-l- carboxamsdo)-W~(2 _f 4~diffuoro~3-(2,2 _? 2-triffuoroacetarnido}phenyS}ben-iam!de ^ IF JLS 33

Isolated as a white solid (0.121 g, 79%).

i¥-(3~Acetamido-2,6-dif!uorophenvl)-2-chloro~5~{(l^ _f 3^}-2,2~dschforo-3~(3 _f 4~ dichiorophenyS)cvciopropane-l-carboxamido}ben2:amsde (FI536)

Isolated as a white solid (0.131 g, 90%).

2-ChSoro-5~((ll?,3l?)~2 _f 2~dich!oro~3~{3,4~dichforophenyf)cvclopropane~l~ carbo¾amido)~i¥~(2 _f 6~difluoro~3~(2 _f 2 _f 2~tnflu >roacetamido)phenv ^, l)benzamide (FI537)

Isolated as a white solid (0.141 g, 91%). 2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~

Isolated as a white solid (0.138 g, 90%). fuoro-3-(trifluoromethy!}pheny!)cycSopropane-l"

(F1539)

isolated as a white solid (0.127 g, 90%).

2-Ch!oro-S-((l^,3^)-2,2-dschSoro-3-(4-f!uoro-3- (trif!uoromethv pheny cycSopropane-l- difluoroacetamsdo)-2 _f 4-dsfluorophenv!)ben2:a!T!!de (FI540)

Isolated as a tan solid (0.137 g, 94%).

2-ChSoro-5-{(Ii? _f 3i?)-2,,2-dsch!oro-3-(4- ^""

(tnfluoromethyS}phenv!)cvc!opropane-I-carboxamido)- f-(2 _? 4-difluoro-5- (2,2,2~triffuoroacetarnido)phenyS}ben-5:am!de (FIB

Isolated as a white solid (0,133 g, 89%). ferf-Butyf (3-(2~chSoro-5-{(ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~ (triffuorom8thyS}phenyl)cvc!opropan8~l~carbo3amido)ben¾amid o)~2 _f 4~ diffuoropheny!}carbamate (F1542)

Isolated as a white solid (0.712 g, 93%).

ferf-Butyf /¥-fert-butoxycarbonyhi¥-[5-[[2-choro-5-[[Cl?,3?}-2 _f 2-dschtoro-3- [4-f!uoro-3-

(trifuoromethy phenyncycSopropanecarbonynaminolbenzoynaminol- ^- difuoro-phenyHcarbamate (FI563)

isolated as a white solid (0.310 g, 90%).

2-Ch!oro-S-((l^,3^)-2,2-dschSoro-3-(4-f!uoro-3- (tnfluoromethyS}pheny!)cyc!opropane-I-carboxamido)-4-f uoro-/¾'- phenylbenzamsde

Isolated as a light-tan solid (0.070 g, 79%),

2-ChSoro-5-((l ?,3?}-2 _f 2-dschtoro-3-(4-fSuoro-3-

(tnf uoromethy!)pheny!)cycSopropane-l-carboxam!do)-4-fluoro-/¥-{ 4- fuorophenyS)ben¾amsde (F1725)

Isolated as a !ight-tan solid (0.091 g, 97%),

2-ChSoro-5-((ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethv ^, S}phenyi}cycfopropane-l-carboxamido}-/ '-(2,4-dif uorophenv!}- 4-fiuorobenzamide (F1727)

isolated as a white solid (0.085 g, 88%).

2~Chloro~5~((l^ _f 3^)-2,2~dschSoro-3~(4~fluoro-3- (trif!u jromethyt}pheny!}cycSopropane-l-carboxamido}-i¥-(3-(2,2- dif!uoroacetamsdo)-2j4-dsfSuorophenyi)-4-flu 3robenzamide (F1729)

Isolated as a white solid (0.093 g, 83%).

ferf-Butyf /¥-fert~butoxycarbonyf~i¥-[3~[[2~chforo~S~[C(ll?,3l?)~2 _f 2~dich!oro~3~ [4-f!uoro-3-(trifluoromethyS}phenyi]cycfopropanecarbonyi]ami no]-4-f!uoro- benzQynamino]-2 _? 6-dsfliuorG-phenyl]carba ate (Fi 30)

Isolated as a white solid (0.102 g, 79%).

5~{(1^3^}-2,2~Dich!oro~3~{3,4 _f 5~tnchlorophenyS)cyclopropane-l~

carboxamsd j}-W-(2,6-dif!u 3ro-3-nstropheny }-2,3"^i^^orobenzamide (FI765)

Isolated as a white foam (0.425 g, 44%).

tett -Butyl (3-(2~chSoro-5-{(ll?,3l?)~2 _f 2~dich!oro~3~{4~fSuoro~3~

(tnf uoromethyS}phenyi}cycfopropane-l-carboxamido)benzamido)-2 _f 6- diffuoropheny!}(prop-2-yn-l-y!}carbamate (F188I)

Isolated as a yellow oil (0.33 g, 80%).

fert-Buty! (3-C2-ch!oro-S-{(l^,3^)-2,2-dichSoro-3-(4-f!uoro-3- (trif!ujromethyt}pheny!}cycSopropane-l-carboxamido}benzam!do )-2,6- difluorophenyl)(2-f!uoroethyS)carbamate (F1882)

Isolated as an amber oil (0,24 g, 63%),

ferf-Buty {3-(2-chSoro-5-((l ?,3?}-2 _f 2-dichtoro-3-(4-fSuoro-3- (tnf uoromethyS}phenyi}cycfopropane-l-carboxamido)benzamido)-2 _f 6- dif§uorophenyl}( propyl! )carba ate (FI883)

Isolated as a white foam (0.55 g, 65%).

2-Chloro-5-((l^ _i ,3^)-2 _f 2-dschSoro-3-(4-fluori-3- (triffuoromethy!)phenyf)cycSopropane~l~carboxamido)~M~ethyS- 4~ ffuorobenzamide (F2083)

Isolated as a white so!id (0.051 g, 63%).

2-€ΗΙθΓθ-5-(( 1^,3^)-2,2-€ίεΗ§θΓθ-3-(4-ΑυοΓθ-3- (triffuoromethy!)phen¾ff )cycSopropane~l~caf

trif!uoroethyl)benzamide (F2084)

Isolated as a white solid (0,070 g, 78%).

2-€ΗΙθΓθ-5-{(Ιί?,.3ί?)- ,,2-«^ίεΗ!θΓθ-3-(4-ΐΙυο!Ό-3-

(triffuoromethyS}phenyl)cyc!opropane~l-carbo3camido)~4~ff uoro~ ¥~(2 _f 2,3 _? 3 _f 3- pentafSuoropropyS)ben_iam!de (F20S5)

Isolated as a white solid (0.078 g, 80%).

The following compounds were prepared In like manner to the procedure outlined in

Ethyl (3~(2-chforo~5~((II? J ?)~2 _f 2~dichSoro-3-{3 _f 4~

dichlorophenyS)cyclopropane-l-carbo amido}benz:amsdo}~2 _f 6- dif!uarophenyl)carbamate (F1476)

Isolated as a tan foam (0.034 g, 30%).

The following compounds were prepared In like manner to the procedure outlined in

2-Ch!oro-S-((l^,3^}-2,2-dschSoro-3-(3 _f 4-dichioropheny!)cycSopropane-l- carboxamsd j}-3-methytbenzoic acid (C224)

Isolated as a white solid (0,60 g, 77%): mp 212 - 215 °C; ¹ H NMR (400 MHz, Acetone-de) δ 11.30 (or s, 1H), 10.09 (s, 1H), 8.07 (d, J = 2.7 Hz, 1H), 7.83 (d, J = 2.7 Hz, 1H), 7,68 (d, J = 1.9 Hz, 1H), 7.63 (d, J = 8.3 Hz, 1H), 7.45 (dd, J = 8,3, 1.7 Hz, 1H), 3.63 (d, J = 8,3 Hz, 1H), 3,38 (d, J = 8,3 Hz, 1H), 2,42 (s, 3H); ¹³ C NMR (101 MHz, Acetone-de) δ 166,20, 162,50, 138,25, 137.21, 134.35, 132,38, 131.88, 131,48, 130.99, 130.54, 129.20, 126.66, 123.79, 119.06, 62.01, 39.28, 37.38, 19.94; ESIMS m/z 468 ([Μ + ΗΓ).

2~Chloro~5~((l^ _f 3^)-2,2~dschSor>-3~(3 _f 4 _f 5-trichf >rophenyf)cvcf >propane~l~ carbGxamsdo}-3-meth¥l! benzoic acid (C22S)

Isolated as a white solid (0,635 g, 85%): mp 195 - 200 °C; ^J H NMR (400 MHz, Acetone-ce) δ 10.09 (s, 1H), 8.06 (d, J - 2.6 Hz, 1H), 7.83 (d, J - 2.5 Hz, 1H), 7.71 (d, J = 0.8 Hz, 2H), 3.66 (d, J = 8,3 Hz, 1H), 3,45 (d, J = 8.3 Hz, 1H), 2.42 (s, 3H); ¹³ C NMR (101 MHz, Acetone-ds) δ 166,18, 162.30, 138.26, 137.18, 134.90, 133.64, 132,39, 130,22, 129,76, 126.70, 123,79, 119,07, 61.79, 39,34, 37.08, 19,94; ESIMS m/z 501 ([Μ + ΗΓ),

2-€ΗΙθΓθ-5-((1^,3^)-2,2-€ίεΗ¾θΓθ-3-(4-Αυο Γθ-3-

(tnfiuoromethv!)phenv ^, i)cyciopropane-l-carboxam!do)-3-methvibenTOsc acid (C226)

Isolated as a white solid (0,570 g, 75%) : mp 190 - 193 °C; *H N R (400 MHz, Acetone-de) δ 11.39 (or s, IH), 10.08 (s, IH), 8.07 (d, J = 2.6 Hz, IH), 7.87 - 7.81 (m, 3H), 7.48 (t, J = 9.9 Hz, IH), 3.71 (d, J = 8,3 Hz, IH), 3,43 (d, J = 8.3 Hz, IH), 2.42 (s, 3H); ⁱ⁹ F NMR (376 MHz, Acetone-de) δ -61.87 (d, J = 12,8 Hz), -117,65 (q, J = 12.8 Hz); ESIMS m/z 484 ([M + H] ⁺ ).

5-{{ l^ _i 3^)-2 _f 2-Dich!oro-3-(3 _f 4-dich oropheny cvciopropane-l-carboxamsdo)- 2~ffuorobenzoic acsd

Isolated as a grey foam ( 1.6 g, 93%) : ^l H NMR (400 MHz, DMSO-c e) δ 13,32 (s, IH), 10.86 (s, IH), 8.21 (dd, J = 6,6, 2.8 Hz, IH), 7,85 (ddd, J = 9,0, 4, 1, 2,8 Hz, IH),

7.75 (d, J - 2.1 Hz, IH), 7.69 (d, J - 8,3 Hz, IH), 7,42 (dd, J = 8.4, 2.2 Hz, IH), 7,31

(dd, J - 10,5, 8.9 Hz, IH), 3.59 (d, J - 8.5 Hz, IH), 3.43 (d, J - 8.5 Hz, IH); ¹⁹ F NMR

(376 MHz, DMSO-c e) δ -116,06; ESIMS /z 438 ([M + H] ).

5~{(l^ _f 3^}-2,2~Dich!oro~3~{3,4 _f 5~tnchlorophenyS)cyclopropane-l~

carboxamsd j}-2-fiuorobenzoic acsd (C228)

Isolated as a brown foam (1, 15 g, 80%) : *H NMR (400 MHz, DMSO-de) δ 13,34 (s, IH), 10.83 (s, IH), 8.21 (dd, J = 6.6, 2.8 Hz, IH), 7.85 (ddd, J = 9.0, 4.2, 2.9 Hz, IH), 7.80 (s, 2H), 7.32 (dd, J - 10.5, 8.9 Hz, IH), 3,62 (d, J - 8.5 Hz, IH), 3.51 (d, J - 8.5 Hz, IH); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -116.06; ESIMS m/z ATI ([M + H] ⁺ ),

5~C(ll?,3J?)~2 _f 2~DichSoro~3-(4~fluoro-3-{trifluoromethyf )phenyS}cycfopropane~l- carbo3 amsdo)~2~ff uorobenzoic acsd (C229)

Isolated as a cream solid (1,01 g, 88%) : Η NMR (400 MHz, DMSO-c e) δ 13,34 (s, IH), 10.86 (s, IH), 8.22 (dd, J - 6.6, 2.9 Hz, IH), 7.90 - 7.78 (m, 3H), 7.59 (dd, 3 = 10.7, 8.6 Hz, IH), 7.32 (dd, J = 10.5, 8.9 Hz, IH), 3.68 (d, J = 8.4 Hz, IH), 3.47 (d, J = 8.5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-d6) δ -59.92 (d, J = 12.9 Hz), -116.06, - 116,98 (q, J = 13.0 Hz); ES!MS m/z 454 ([M + H] ),

5-((l/?,3?)-2,2-Dichloro-3-C3,4,5-trichlorophenyl)cyclopropa ne-l- carboMamsdo)-2j3-dsfSuorobenzosc acid (C230)

Isolated as a brown foam (0.73 g, 88%); *H NMR (400 MHz, DMSO-de) δ 13.69 (s, 1H), 11.02 (s, 1H), 8,00 (ddd, J - 12.2, 6,6, 2.7 Hz, 1H), 7.93 (dt, J - 4,7, 2.0 Hz, 1H), 7,81 (d, J = 0,7 Hz, 2H), 3,66 - 3,61 (m, 1H), 3,53 (d, J = 8,5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO- s) δ -135,50 (d, J = 22.7 Hz), -142.58 (d, J = 22,6 Hz); ESIMS m/z 488 ([M + HD.

2-ChSoro-5-{(Ii? _f 3i?)-2 _i ^, 2-dsch!oro-3-(4-fSuoro-3-{tnfluoromethy pHeny - cyc!opropane-i-carboxamido)-4-fluoroben2:osc acsd (C23i)

Isolated as a cream-colored solid (1.23 g, 68%); mp 188 - 191 °C; ^J H NMR (400 MHz, DMSO-de) δ 13.54 (s, 1H), 10.73 (s, 1H), 8.60 (d, J = 8.4 Hz, 1H), 7.82 (ddd, J = 11.1, 6.0, 2.4 Hz, 2H), 7.68 (d, J = 10.7 Hz, 1H), 7.60 (dd, J = 10.7, 8.5 Hz, 1H), 3.73 (d, J - 8.5 Hz, 1H), 3.68 (d, J - 8.6 Hz, 1H); ⁾⁹ F NMR (376 MHz, DMSO-de) δ -59.94 (d, J - 12.4 Hz), -116,92 (q, J - 12.4 Hz), -118.01; HRMS-ESI (m/z) [M + ] ⁺ calcd for CisHgC FsNOs, 486,9568; found, 486,9579,

2-ChSoro-5-((l ?,3R}-2 _f 2-dschtoro-3-(4-fSuoro-3-{tnf!uoromethy }phenyt)- cyciopropane-l-carboxamido)ben2:oic acid (C232)

Isolated as a tan solid (5.8 g, 93%): ^'! H NMR (400 MHz, DMSO-de) δ 13.48 (s, 1H), 10.94 (s, 1H), 8,17 (d, J = 2.7 Hz, 1H), 7.94 - 7,72 (m, 3H), 7,68 - 7.44 (m, 2H), 3.68 (d, J = 8,4 Hz, 1H), 3,49 (d, J = 8.5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-c e) δ - 59.93 (d, J = 12.6 Hz), -116.95 (q, J = 12,5 Hz); ESIMS m/z 472 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 40:

frans-2 _f 2-D!chloro-3-(3-f!uoropheny cvciopropane-l-carboxy c acid (C233)

Isolated as a pale yellow solid (2.8 g, 52%) : H NMR (400 MHz, DMSO-c/e) δ 13,39 (s, 1H), δ 7.46 - 7,39 (m, 1H), 7,29 (t, J = 8,0 Hz, 2H), 7,21 - 7, 15 (m, 1H), 3. (d, J = 8.0 Hz, 1H), 3.41 (d, J = 8,8 Hz, 1H); ESIMS m/z 247.11 ([M-H ] ).

frans-2 _f 2-D!chloro-3-(3-ch!orophen¾f!)cv'c!opropane-i-carb ix¾ ^r ! !C ac d {€234}

Isolated as a white solid (1.1 g, 23%) : ^J H NMR (400 MHz, DMSO-c e) δ 13.39 (s, 1H), 7.52 (s, 1H), 7.42 - 7.38 (m, 3H), 3.45 (d, J = 8.4 Hz, 1H), 3.41 (d, J - 8.4 Hz, 1H); ESIMS m/z 262.73 ([M-H] ^" ).

trans~3~(3~Bromophenvf }-2,2~dichlorocvcfopropane~l~carboxv c acid (C23S)

Isolated as a white solid (1,25 g, 26%) : H NMR (400 MHz, DMSO-c e) δ 13,41 (s, 1H), 7.66 (s, 1H), 7,54 (d, J = 7.6 Hz, 1H), 7.43 (d, J = 7.6 Hz, 1H), 7.34 (t, J = 8,0 Hz, 1H), 3.45 (d, J = 8,8 Hz, 1H), 3,42 (d, J = 8,4 Hz, 1H); ESIMS /z 307.05 ([M-H] ^' ) frans-2 _f 2-D!chloro-3-(3-{trif!uoromethoxy)phenyi)cyciopropane- I-carboxy!sc acid (€236)

Isolated as a pale yellow solid (1.8 g, 38%) : *H NMR (400 MHz, DMSO-c e) δ

13.39 (s, 1H), 7, 54 - 7.43 (m, 3H), 7.34 (d, J = 8,0 Hz, 1H), 3, 51 (d, J = 8.8 Hz, 1H), 3.44 (d, J = 8,8 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSG-d ₆ ) δ -56.76; ESIMS m/z 312,77 ([M-H]-).

frans-2j2-DichSoro-3-(4-f!u 3rophenyS)cvciopropane-l-carboKy c acid (C237)

Isolated as a white solid (2,5 g, 43%) : ^j H NMR (400 MHz, DMSO- s) δ 13.39 (s 1H), 7.46 - 7,42 (m, 2H), 7,23 - 7.17 (m, 2H), 3.41 (d, J = 8,4 Hz, 1H), 3,30 (d, J = 8 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSG- e) δ -114.31; ESIMS m/z 246,78 ([M-H] ).

frans-2j2-DichSoro-3-(4-chioropheny!)cyciopropane-I-carb 3xy!ic acsd (C238)

Isolated as a pale yellow solid (2.4 g, 44%) : *H NMR (400 MHz, DMSO-de) δ 13,29 (s, 1H), 7.48 - 7.42 (rrt, 4H), 3.43 (d, J = 8.8 Hz, 1H), 3.33 (d, J = 8,8 Hz, 1H); ESIMS m/z 262,73 ([M-H] ).

frans-3-{4-Bromophenv'!)-2 _f -d!chSor icyci ipropane-l-carboxyyc acid (C239)

Isolated as a white solid (0.45 g, 9%) : *H NMR (400 MHz, DMSO-c e) δ 7.56 (d, 3

= 8,8 Hz, 2H), 7,36 (d, J = 8.0 Hz, 2H), 3.38 (d, J = 8.4 Hz, 1H), 3.28 (d, J = 8,4Hz _f 1H); ESIMS m/z 306.72 ([M-H] ^" ).

The following compounds were prepared In like manner to the procedure outlined in Example 51 :

frans-2,2-D!chioro-3-{4-f!uoro-3-iodophenyi)cyc!opropane- I-carboxyiic acid (C240)

Isolated as a white solid (1,35 g, 80%) : mp 147 - 149 °C; ^"! H NMR (400 MHz, CDC ) δ 7.67 -7.62 (m, 1 H), 7.62 (dd, J = 6.4, 2.4 Hz, 1H), 6.93 - 6.88 (m, 1H), 3.45 (d, J = 4.4 Hz, 1H), 2.88 (d, J = 4.4 Hz, 1H); ESIMS m/z 374.98 ([M + H] ⁺ ).

frans-2j2-DichSoro-3-(3-Ctrif!uoromethy )phenv!}cyc!opropane-I-carboxyyc add (C241)

Isolated as a white solid (24 g, 43%) : H NMR (400 MHz, CDCb) δ 9.55 (s, 1H), 7.66 - 7.59 (m, 1H), 7.57 - 7,44 (m, 3H), 3,55 (d, J = 8.3 Hz, 1H), 2.94 (d, J = 8.3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDC ) δ -62.70; ESIMS m/z 298 ([M-H]-).

The following compounds were prepared In like manner to the procedure outlined in Exampie 55:

(li? _? 3i?)~3~(3~Bromo~4~chforopheny!)~2 _? 2-dichforoc¾fc!opropane~l~carboxyfic acid (C242)

Isolated as a white solid (1,05 g, 42%, 93% ee) : *H NMR (400 MHz, CDCb) δ

7.53 (d, J = 2, 1 Hz, 1H), 7,47 (d, J = 8,3 Hz, 1H), 7, 17 (dd, J = 8.4, 2, 1 Hz, 1H), 3.43 (d, J - 8.2 Hz, 1H), 2.86 (d, J - 8.3 Hz, 1H); ESIMS m/z 343 ([M-H] ^" ). Racemic trans-3- (3-bromo-4-chlorophenyl)-2,2-dichlorocydopropane-l-carboxyli c acid can be prepared via methods described in U.S. Patent Application Publication US20160304522A1 (C422), The title compound was obtained from the racemate using (S)-l-phenylethan-l-amine and example 55 conditions.

The following compounds were prepared in like manner to the procedure outlined in Exampie 57:

ferf-Butyf /¥~[5~[(S~amsno~2~chSoro~3~fSuoro~benioyf )arnino]~2 _f 4~difSuoro~ phenyn-W-ferf-butoxycarbonyf-carbamate (C245)

Isolated as a light-orange solid (3.125 g, 79%) : 143 - 152 °C; *H NMR (400 MHz, DMSO-Λ) δ 10,38 (s, 1H), 7.69 (t, J = 8.1 Hz, 1H), 7.52 (t, J = 10, 1 Hz, 1H), 6.59 (ddd, J = 7.7, 5.5, 2.5 Hz, 2H), 5.81 (s, 2H), 1 ,40 (s, 18H); ¹⁹ F NMR (376 MHz, DMSO- dt) δ -115,57, -117,36, -117.38, -121.88, -121.90; HRMS-ESI (m/z) [ + ] ⁺ calcd for C23H25CI F3N3O5, 515, 1435; found, 515, 1438.

The following compounds were prepared In like manner to the procedure outlined in Example 61 :

W-(2,6-D!f uoro-3-nstrophen - -ethvi-2,2-diff uoroacetamsde (C246)

Isolated as a gold oil (0,45 g, 25%) : *H NMR (400 MHz, CDC ) δ 8.39 - 8.15 (m, 1H), 7.21 (dddd, J = 11.9, 9.7, 7,9, 2.0 Hz, 1H), 6.08 (dt, J = 154, 5, 53,3 Hz, 1H), 4,01 - 3,69 (m, 2H), 1,21 (tt, J = 7,3, 1.2 Hz, 3H); ESIMS m/z 280 ([M + H] ⁺ ).

W-Ayvl-Af-{2 _i 6-dsfSuoro-3-n!trophenvl)-2 _f 2-dsfluoroacetam!de (C247)

Isolated as a gold oil (0,21 g, 12%) : ^L H NMR (300 MHz, CDCb) δ 8.23 (dddd, J = 15.3, 9.5, 8.1, 5,5 Hz, 1H), 7,35 - 7.09 (m, 1H), 6.54 - 5.71 (m, 2H), 5,30 - 5.09 (m, 2H), 4.52 - 4.25 (m, 2H); ESIMS m/z 293 ([M + H] ⁺ ),

i¥-{2 _f 6~Diffuoro~3-nstrophen ~^~methySacetamide (€248)

Isolated as a tan solid (1.02 g, 61%); H NMR (400 MHz, CDCb) δ 8.15 (dddd, J = 31.6, 9,4, 8.1, 5.5 Hz, 1H), 7.32 - 7.05 (m, 1H), 3.31 (d, J = 53.3 Hz, 3H), 2.13 (d, J = 164.4 Hz, 3H); ESIMS m/z 231 ([M + H] ⁺ ).

ferf-Butyf {2,6-dif!uoro-3-nitrophenvi){ethyt)carbamate (C249)

Isolated as a yellow oil (0.4 g, 69%); ^l H NMR (400 MHz, CDCb) δ 8.21 - 8.00 (m, 1H), 7.10 (ddd, J = 9.8, 8.2, 2.0 Hz, 1H), 3.62 (dq, J = 25.2, 7.3 Hz, 2H), 1.37 (s, 9H), 1.15 (dt, J = 17,2, 7.2 Hz, 3H); ESIMS m/z 303 (TM + H] ⁺ ).

ferf-Butyf {2 _f 6~difluoro~3~nitrophenyf){prop~2~yn~l~yf)carbamate (C2SO)

Isolated as a yellow oil (0,40 g, 67%): H NMR (400 MHz, CDCb) δ 8.20 - 8,03 (m, 1H), 7.12 (ddd, J = 9.7, 8.2, 2.0 Hz, 1H), 4.53 - 4,28 (m, 2H), 2,21 (dt, J = 20.9, 2.6 Hz, 1H), 1.56 (d, J = 3,4 Hz, 9H); ESIMS m/z 313 ([M + H] ⁺ ).

ferf-Butyf (2 _J ,8~diffuoro~3-nitrophenyl)(2~fluoroethyl)carbamate (C2S1)

Isolated as a yellow oil (0.198 g, 32%): *H NMR (400 MHz, CDCb) δ 8,19 - 7.99 (m, 1H), 7.21 - 7,01 (m, 1H), 4.76 - 4,45 (m, 2H), 4,07 - 3.77 (rrs, 2H), 1.39 (s, 9H); ESIMS m/z 321 ([M+H] ⁺ ).

ferf-Butyf (2 _J ,8~diffuoro~3-nitrophenyl)(propyS)carbamate (C252)

Isolated as a yellow oil (0.350 g, 58%) ; H NMR (400 MHz, CDC ) δ 8,09 (m, 1H), 7.10 (tt, J = 9.5, 4,8 Hz, 1H), 3.64 - 3.48 (m, 2H), 1.56 (d, J =6.1 Hz, 4H), 1.38 (d, J = 7.2 Hz, 7H), 0.92 (p, J = 7.6 Hz, 3H); ESIMS /z 317 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 62:

ferf-Buty {2,,6-dif!uoro-3-nitr iphenv!}{methvS}carbamate (C253)

Isolated as a yellow oil (0.56 g, 76%) ; ^'! H NMR (400 MHz, DMSO-de) rotamers δ 8.32 - 8.19 (m, 1H), 7.49 (td, J = 9.2, 1,9 Hz, 1H), 3, 15 (s, 1H), 3.11 (s, 2H), 1.48 (s, 3H), 1.31 (s, 6H); ¹⁹ F NMR (376 MHz, DMSQ-cfe) rotamers δ -106.79 (d, J = 11 ,4 Hz), -107.54 (d, J = 11.3 Hz), -121.48 (d, J = 11.4 Hz), -122.14 (d, J = 11.4 Hz),

The following compounds were prepared in like manner to the procedure outlined in Example 65:

ferf-Buty! /¥~fert~butoxycarbonyf-i¥~[5-[(2~chforo~3~fSuoro~S~nitro~

benTOy!)amino]~2 _f ~difSuoro~phenvl]carbamat8 (C254)

Isolated as a yellow solid (3.943 g, 85%) ; mp 172 - 175 °C; ^J H NMR (400 MHz, DMSO-de) δ 10.74 (s, 1H), 8.52 (del, J - 8.8, 2.6 Hz, 1H), 8.44 (dd, J - 2.6, 1.4 Hz, 1H), 7.90 (t, J = 8.1 Hz, 1H), 7.57 (t, J = 10.2 Hz, 1H), 1.42 (s, 18H) ; ¹⁹ F NMR (376 MHz, DMSO-Gfe) δ -109.73, -118.21, -118.22, - 121.44, -121.46; HRMS-ESI (m/z) [M+] ⁺ calcd for C23H23CI F3IN3O7, 545.1177; found, 545.1179,

The following compounds were prepared in like manner to the procedure outlined in Example 67:

ferf-Butyf {3~arnino~2,6~diffuoropheny!)(methyf )carbamate (€255)

Isolated as a white solid (0,45 g, 89%): Ή NMR (400 MHz, CDC ) rotamers δ 6.72 (td, J = 9,1, 1.9 Hz, 1H), 6.68 - 6.58 (m, 1H), 3.59 (s, 2H), 3.16 (s, 3H), 1.53 (s, 2H), 1.37 (s, 7H); ¹⁹ F NMR (376 MHz, CDCb) rotamers δ -132.31, -132.53, -138.84, -139.43; EIMS m/z 258.

ferf-Buty N-(S-amino-2-ch oro-pheny )-/¾'-tert-butoxvcarbonv'l-carbamate (C2S6)

Isolated as a grey solid (1.7 g, 78%): H NMR (400 MHz, CDCb) δ 7.15 (d, J = 8.5 Hz, 1H), 6.62 - 6.51 (m, 2H), 3.74 (s, 2H), 1.42 (s, 18H); ¹³ C NMR (101 MHz,

CDCb) δ 150.87, 145.76, 137.39, 129.65, 121.50, 116.14, 115.67, 82.71, 27.85; ESIMS m/z 341 ([M-H]-).

tert-Butyl /¥~(4~amino~2 _f 6~dichSoro~phenyl)~¥~ferf~butoxycarbonyS~carbamate (C257)

Isolated as a tan solid (1.88 g, 85%): ^J H NMR (400 MHz, CDCb) δ 6,64 (s, 2H), 3.95 (s, 2H), 1.41 (s, 18H); ¹³ C NMR (101 MHz, CDCb) δ 150.32, 147.10, 134.34, 125.31, 113,81, 82.64, 27.77; ESIMS m/z 376 ([M-H] ^' ),

ferf-Butyf /¥~(4~amino~2~chforo~phenyf)-M~tert-buto ycarbonyS-carbaniate (C258)

Isolated as a tan solid (1.96 g, 93%); ¹ H NMR (400 MHz, CDCb) δ 6,93 (d, J = 8.5 Hz, 1H), 6.71 (d, J = 2,6 Hz, 1H), 6,52 (dd, J = 8.5, 2,6 Hz, 1H), 3,80 (s, 2H), 1.41 (s, 18H) ; ¹³ C NMR ( 101 MHz, CDCb) δ 151.33, 146.96, 132.95, 130.03, 127.62, 115,23, 113, 59, 82,43, 27.86; ES!MS m/z 341 ([M-H] ) ,

ferf-Butyf /¥-(4-amino-2-c¥ano-pheny )-/¥-fert-butOM¥carbonyS-carbar!iate (C259)

Isolated as a white solid (2,45 g, 85%) : *H NMR (300 MHz, CDCb) δ 7.01 (dd, J = 8.6, 0,4 Hz, 1H), 6,94 - 6.76 (m, 2H), 4.10 (d, J = 7, 1 Hz, 2H), 1 ,43 (s, 18H) ; ¹³ C NMR (75 MHz, CDCb) δ 150,99, 146.11, 132.35, 130.02, 119.18, 117 ,76, 116.21, 113.30, 83.42, 27.85; ESIMS m/z 332 ([M-H] ^" ) .

ferf-Buty! /¥~{4~amino~2 _f 3~dimethyS~phenyS}~Af~fert~butoxycarbonyf~carbamate (C260)

Isolated as a white solid (0.19 g, 38%) : *H NMR (400 MHz, CDCb) δ 6.76 (d, J = 8.3 Hz, 1H), 6.53 (d, J = 8.4 Hz, 1H), 3, 18 (s, 2H), 2.08 (d, J = 1.9 Hz, 6H), 1.42 (s, 18H); ESIMS m/z 335 ( [M-H] ^" ) .

ferf-Butyf /¥~[4~amino~2~(trsf!uoromethyl)phenyf

carbamate (C261)

Isolated as a white solid (0.19 g, 38%) : ^l NMR (400 MHz, CDCb) δ 6,99 - 6.88 (m, 2H), 6.78 (dd, J = 8.5, 2.7 Hz, 1H), 3.99 (s, 2H), 1, 38 (s, 18H) ; ¹⁹ F NMR (376 MHz, CDCb) δ -61.98; ESIMS m/z 375 ( [M-H] ^" ) . ferf-Butyf (5-amino~2~methylphenyI)carba ate (C262)

Isolated as a brown foam (1,33 g, 91%): H NMR (400 MHz, CDC ) δ 6.96 (d, J = 8,1 Hz, 1H), 6,70 (s, 1H), 6,56 (dd, J = 8,1, 2,5 Hz, 1H), 6,44 (s, 1H), 3.48 (s, 2H), 2.06 (s, 3H), 1.43 (s, 9H); ESIMS m/z 221 ([M-H] ^" ),

ferf-Butyf W-CS-amino-S-methy-pheny - f-ferf-butoxycarbonyhcarbamate (C263)

Isolated as a white solid (0,98 g, 89%): Ή NMR (400 MHz, CDCb) δ 6.98 (t, J = 7,9 Hz, 1H), 6,63 (dd, J = 8,0, 1.1 Hz, 1H), 6.55 (dd, J = 7,8, 1.1 Hz, 1H), 3.61 (s, 2H), 1.99 (s, 3H), 1.41 (s, 18H); ¹³ C NMR (101 MHz, CDCb) δ 151,83, 145.13, 138,90, 126,28, 120,32, 118.63, 114.63, 82.19, 27,92, 11,37; ESIMS m/z 323 ([M + H] ⁺ ).

ferf-Buty W-CS-amino-S^-dif uoro-S-methy!-pheny^- f-ferf-butoxycarbonyh carbamate (C264)

Isolated as a tan solid (0.71 g, 83%): ^l NMR (400 MHz, CDCb) δ 6,49 - 6.40 (m, 1H), 3.56 (s, 2H), 2.19 (t, J = 2.1 Hz, 3H), 1.44 (s, 18H); ⁵⁹ F NMR (376 MHz, CDCb) δ

-135.31, -135.93; ESIMS m/z 359 ([M + H] ⁺ ).

W-{3-Amino-2,6-d!fuorophenyt)-/¥-ethy 2 _f 2-difiuoroacetar!i!de (C265)

Isolated as a go!d oil (0.36 g, 86%): ^l H NMR (400 MHz, CDCb) δ 6.94 - 6.75 (m, 2H), 5.80 (t, J = 53.5 Hz, 1H), 3.92 - 3.66 (m, 2H), 1.17 (tt, J - 7.2, 1.1 Hz, 3H); ESIMS m/z 251 ([M+H] ⁺ ).

W-CS-Amino-S^-difuorophen -N-methySacetamsde (C266)

Isolated as a brown oil (0.74 g, 76%): ^J H NMR (400 MHz, CDCb) δ 6.96 - 6.67 (m, 2H), 3.94 (d, J ^™ 47.1 Hz, 2H), 3.20 (s, 3H), 1.91 (s, 3H); ESIMS m/z 231

([M + H] ⁺ ).

ferf-Butyf (3~amino~2 _f 6~difuorophenyS)(ethyS)carbamate (C267)

Isolated as a pink solid (0.36 g, 92%): *H NMR (400 MHz, CDCb) δ 6.87 - 6.58 (m, 2H), 3.60 (dtt, J = 18,7, 11.8, 5.8 Hz, 4H), 1.36 (s, 9H), 1.11 (dt, J = 14.6, 7,1 Hz, 3H); ESIMS m/z 273 ([M+H] ⁺ ),

ferf-Buty {3-amino-2 _? 6-d!fluorophenv (2-fluoroethy)carba!T!ate (€268)

Isolated as a gold oil (0.153 g, 81%): ^'! H NMR (400 MHz, CDCb) δ 6,86 - 6.55 (m, 2H), 4.68 - 4.43 (m, 2H), 3.85 (ddt, J = 26,3, 11.8, 5,8 Hz, 2H), 3,67 (s, 2H), 1.37 (s, 9H); ESIMS m/z 291 ([M + H] ⁺ ).

ferf-Buty {3-amino-2 _? 6-d!fluorophenv (PTOpy carbamate (C269)

Isolated as a tan solid (0.310 g, 93%) : ^J H NMR (400 MHz, CDC 13) δ 6,85 - 6.55 (m, 2H), 3.94 - 2.96 (m, 4H), 1.36 (s, 11H), 0.89 (q, 3 = 7.8 Hz, 3H); ESIMS m/z 287 ([M + H] ⁺ ),

The following compounds were prepared in like manner to the procedure outlined in Example 68;

ferf-Butyf /¥-fert-butoxycarbonyhi¥-( -chioro-5-nitro-phenv!}carbamate (C27Q)

Isolated as a white so!id (2.26 g, 66%) : *H NMR (400 MHz, CDCb) δ 8.20 - 8.10 (m, 2H), 7.63 (d, J = 8.8 Hz, IH), 1.42 (s, 18H); ¹³ C NMR (101 MHz, CDCb) δ 149.83, 146.69, 140.24, 138.31, 130.25, 125,29, 123,68, 84.04, 27.80; ESIMS m/z 373 ([M-H] ^" )■

fert-Buty! f-terf-butoxvcarbonv -W-(2,6-dichSoro-4-n!tro-phenyt)carbamate (C27I)

Isolated as a go!d oil (2.26 g, 73%) : ^l NMR (400 MHz, CDCb) δ 8.25 (s, 2H), 1,41 (s, 18H); ¹³ C NMR ( 101 MHz, CDCb) δ 152.16, 148.46, 146.81, 141.22, 135,61, 123, 13, 84,25, 27.69; ESIMS m/z 408 ([M-H] ),

ferf-Butyf /¥-fert-butoxycarbonyhi¥-(2-chioro-4-nitro-pheny!}carbamat e (C272)

Isolated as a white solid (3,3 g, 97%}: ^J H NMR (400 Hz, CDC 13) δ 8.34 (d, J - 2.6 Hz, 1H), 8.17 (dd, J - 8.7, 2.5 Hz, 1H), 7.43 (d, J - 8.7 Hz, 1H), 1.41 (s, 18H); °C NMR (101 MHz, CDCb) δ 149.57, 147.24, 143.02, 134.09, 130.62, 124,92, 122.33, 83.99, 27.76; ESIMS m/z 371 ([M-H] ),

Isolated as a yellow solid (3,0 g, 86%): H NMR (300 MHz, CDCb) δ 8.56 (d, J = 2.6 Hz, 1H), 8.47 (dd, J = 8.8, 2,6 Hz, 1H), 7,52 (d, J = 8,8 Hz, 1H), 1.47 (s, 18H); ¹³ C NMR (75 MHz, CDCb) δ 149,52, 147,35, 146.52, 130.85, 128.04, 128,01, 114.68, 114.00, 85.19, 27.81; ESIMS m/z 362 ([M-H] ^" ).

ferf-Butyf N~fert~butoxycarbonyf-N~(2 _f 3~dimet

Isolated as a white solid (0.52 g, 25%): ^l H NMR (400 MHz, CDCb) δ 7.63 (d, J - 8.6 Hz, 1H), 7.09 (d, J = 8.6 Hz, 1H), 2.42 (s, 3H), 2.20 (s, 3H), 1,42 (s, 18H); ¹³ C NMR (101 MHz, CDCb) δ 150.90, 150.17, 141,64, 137,39, 131.88, 126.47, 121.86, 83.36, 27.89, 15,94, 14,65; ESIMS m/z 365 ([M-H] ).

fert-Buty! f-terf-butoxycarbony-W-[4-nstro-2- (tnfluoromethyS}pheny!]carbamate (C275)

Isolated as a yellow solid (2,93 g, 94%): *H NMR (400 MHz, CDC!?,) δ 8.58 (d, J = 2,6 Hz, 1H), 8.45 (dd, J - 8,7, 2.6 Hz, 1H), 7.50 (cl, 3 - 8,7 Hz, 1H), 1,39 (s, 18H); ⁱ⁹ F NMR (376 MHz, CDCb) δ -62,25; ESIMS m/z 405 ([M-H] ).

ferf-Butyf (2-methyh5~niitrGphenyl)carba ate (C276)

Isolated as a white soild (1.58 g, 63%): *H NMR (400 MHz, CDCb) δ 8,21 (s, 1H), 8.14 (dd, J = 8.5, 2,3 Hz, 2H), 7.43 (d, J = 8.4 Hz, 1H), 2.40 (s, 3H), 1.45 (s, 9H); ⁱ³ C NMR (101 MHz, CDCb) δ 151.02, 146.64, 138,69, 131,30, 123.88, 123.38, 84.52, 27.86, 18.10; ESIMS m/z 253 ([M+H] ⁺ ).

tert-Butyl /¥~£ ^, ert~butO ycarbonyf-i¥~(2-niethvf~3~nitro-phenyS)carbamate (C277)

Isolated as a white soild (1.15 g, 31%): ^l H NMR (400 MHz, CDCb) δ 7.91 - 7,81 (m, 1H), 7.41 - 7,25 (m, 2H), 2,37 (s, 3H), 1.41 (s, 18H); ESIMS m/z 353 (TM + H]+), ferf-Buty W-£-ert-butoxycarbonyhi¥-(2 _f 4-d!f uoro-3-methy!-S-n!tTO- phenyl)carbamate (C27S)

Isolated as a gold solid (0.87 g, 40%) ; ^"! H NMR (400 MHz, CDCb) δ 7,88 (t, J = 7.7 Hz, 1H), 2.32 (t, J = 2.2 Hz, 3H), 1.46 (s, 18H); ⁱ⁹ F MR (376 MHz, CDC ) δ

-108.86, -108,91, -115,35, -115,39; ESIMS m/z 389 ([M + H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 70:

f-(3-Amino-2 _? 4 _f 6-tnf uorophenyS)acetamsde (C279)

Isolated as a tan solid (2.8 g, 37%-three steps from 2,4,6-trifluoroaniline) : H NMR (400 MHz, DMSO-ds) δ 9.50 (s, 1H), 7.11 - 7.00 (m, 1H), 5.07 (s, 2H), 2.04 (s, 3H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -131.69, -131.69, -131.72, -131.73, -134,98, - 135.69, -135.70, -135.72, -135,73; ESIMS m/z 205 ([M+H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 4 :

( l¾3^)-3-C 3-Bromo-4-fSuorophenv!)-2 _i ,2-dich!oroc¾ ^r c!opropane-I-carboxy c acid (€243)

Isolated as a white solid (4,0 g, 40%) : ^J H NMR (400 MHz, CDCb) δ 7.53 (d, J = 2.1 Hz, 1H), 7.47 (d, J - 8,3 Hz, 1H), 7, 17 (dd, J = 8.4, 2, 1 Hz, 1H), 3,43 (d, J - 8.2 Hz, 1H), 2,86 (d, J - 8.3 Hz, 1H); ESIMS m/z 343 ([M-H] ^" ). Racemic trans-3-(3-Bromo- 4-fluorophenyl)-2,2-dichiorocyclopropane-l-carboxy!ic acid can be prepared via methods described in U.S, Patent Application Publication US20160304522A1 (C430).

(l^ _f 3^}-2,2-Dich!oro-3-{4-chtoro-3-(trsf!uoromethvi}phenyt )cyc!opropane-I- carboxy!sc acid (C244)

Isolated as a white solid (0,37 g, 25%, 97% ee): *H NMR (400 MHz, DMSG-de) δ 13.41 (s, 1H), 7.96 (d, J = 1.6 Hz, 1H), 7.79 - 7.71 (m, 2H), 3.69 - 3,50 (m, 2H). (l ¾,3?)-2 _J ,2~Dichloro~3~(3~{trifluoromethyf)phenyS}cycfc5propane ~l~carbo5ySic acid (€280)

Isolated as a white solid (3,4 g, 95% ee, 26% yield): ^J H NMR (400 MHz, CDC ) δ 10.38 (s, 1H), 7.66 - 7.59 (m, 1H), 7.57 - 7.44 (m, 3H), 3.55 (d, J - 8.3 Hz, 1H), 2.94 (d, J = 8.3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62.70; ESIMS m/z 298 ([M-H]-) (l^ _f 3^}-2,2~Dichloro~3~{3-fSuoro~5~(triffuoromethyf)phenyl )cycopropane~l~ carboxylsc acid (C28I)

Isolated as a white solid (2.5 g, 95% ee, 24% yield): ^X H NMR (400 MHz, CDCb) δ 10.93 (s, 1H), 7.34 (dd, J = 7.1, 1.9 Hz, 2H), 7.20 (dt, J ^~ 8.8, 2.0 Hz, 1H), 3.54 (d, J - 8.3 Hz, 1H), 2.93 (d, J = 8.3 Hz, 1H); ¹⁹ F NMR (376 MHz, CDCb) δ -62.86, -109.50; ESIMS m/z 316 ([M-H] ^" ).

Example 82: Preparation of /¥~(3~ac8tamsdo~2 _f 6~dif uorophenyS}~2~chSoro-5~ ((Ii?,3#?)-2,2-dichSoro-3-(3 _f 5-dichi3rophenyS)cyci3propane-l-carboMamsdo}-3- fiuorobenzamide (F1505)

A -(3-Amino-2,6-difluorophenyl)-2-chloro-5-(( l ?,3 ?)-2,2-dichloro-3-(3,5- dichlorophenyl)cyclopropane- l-carboxamido)-3-fluorobenzamide (F 1336) (0.041 g, 0.069 mmoi) and sodium bicarbonate (0.029 g, 0.343 mmoi) were weighed into a 1- dram via! containing a stir bar. Ethyl acetate (0.7 mL) was added, and acetyl chloride (6 μΙ_, 0.084 mmoi) was added via syringe. The heterogeneous mixture was allowed to stir for 3 hours at room temperature. The reaction mixture was diluted with ethyl acetate and saturated aqueous sodium bicarbonate; the Iayers were separated ; and the organic layer was dried over sodium sulfate. Filtration and concentration gave the title compound as a white powder (0.044 g, 100%) .

The following compounds were prepared In like manner to the procedure outlined in Example 82 :

i¥-(3-Acetamsdo-2,6-difluorophenv! }-2-ch!oro-5-{( IW _f 3^}-2,2-dsch!oro-3-(3 _f 4 _f 5- tr!chSorophenvl )cycSopropane-l-carboxam!do}-3-fluorobenEamide ( FIS20)

Isolated as a tan powder (0.044 g, 98%) .

W~(3-Acetamsdo~2 _f 6~difSuorophenyS )~2~chSoro-5~{{ ll? _? 3i?)~2 _f 2~dichforo~3~(3 _i ,4- dichforopheny!)cycf >propane~l~carboxamido)~3-methy!benzamide ( F1S23)

Isolated as a tan powder (0.052 g, 100%) i¥~(3~Acetamsdo~2 _f 6~difSuorophenyS)~2~chSoro~5-{(ll?,3l?)~2 _f 2~dichforo~3- trichSorophenvl}cycSopropane-l~carboxamido)~3-niethvfbenz:am sde (F152

Isolated as a tan solid (0.053 g, 92%).

^-(3-Acetamsdo-2 _f 6-difluorophenvS)-2-chSoro-S-C(I ? _i .3i?)-2 _i ,2-dschl

luoro~3~(trifSuorometh¥!)phenyf )c¥cSopropane~l~carboxarnido}~3~

nethvtbenzamsde (F1525)

Isolated as a tan powder (0.036 g _f 91%).

~(3-Acetamsdo~2 _f 4~difSuorophenyS)~2~chSoro-5-{(ll?,3l?)~2 _f 2~dichforo~3- i ^, f )c¥c!opropane-l-carboxamido)-3-m

Isolated as a tan powder (0,029 g, 97%),

■Acetamsdo-2 _? 4-difluorophenv'l)-2-chloro-S-{{ l^ _i 3^)-2 _f 2-dsch oro-3-(3 _f 4 _i ,5- !orophen¥S)cyc!opropane~l-carbo3camido)~3~meth¥ibenzamide (F1S44)

Isolated as a tan powder (0.052 g, 94%), N~(3- acetamido~2,4~dif!uorophenvl)-2-ch!oro~5~(i I^ _f 3^)™2,2~dschforo- uoromethyl)pheny!)cyc!Gpropane-l™€

45)

Isoiated as a tan powder (0,039 g, 99%) ,

W-{5-Acetamsdo-2 _? 4-difluorophenvl )-2-chloro-S-{( l^ _f 3^)-2 _f 2-dsch oro- dichlorophenyS)cyclopropane-l~carboxarnido}~3~methySben-iarn ide (¥11

Isolated as a peach-colored powder (0,044 g, 98%) ,

i¥-(5~Acetamido-2,4-dif!uorophenyl }-3-(( l«,3«)~2 _f 2-dich!oro~3~{3,4,S~ !orophenyS )cyc!opropane~l-carbo3 amido)~S~methyiben2amide (FIE

Isolated as an off-white solid (0,048 g, 78%) ,

/¥~(5~Acetamsdo~2 _f 4~difSuorophenyS )~2~chSoro~5-{( l/?,3/?)~2 _f 2~dichforo~ fiuoro~3~(trifSuoromethy!)ph8nyl)cycSopropane~I-carboxamido) ~3~ methylbenzamide (F1548)

Isolated as an off-white solid (0.037 g, 94%) .

E ample S3; Preparation of 6-ch!oro~3~({ l^ _f 3^)~2,2-dichforo~3~(3-chloro~4~ f uorophenyt)cyc!opropane-I-carboxamsd j}-2-fiuoro-i¥-(4- f uorophenyt)benxamsde (F1465)

Step 1 : To a solution of fert-butyl (4-chloro-2-fluoro-3-((4- fl uorophenyl)carbamoyl)phenyl)carbamate (C310; 0.066 g, 0.172 mmol) in

dichloromethane ( 1 mL) was added hydrogen chloride (0.431 mL, 1.724 mmol) as a 4 M sol ution in dioxane, and the resuiting turbid mixture was stirred at room temperature for 16 hours. The solvent was evaporated under reduced pressure and the residue was suspended i n dichloromethane and concentrated under a stream of nitrogen to give the intermediate hydrochloride salt which was used immediately in the next step.

Step 2: To a mixture of ( l ?,3 ?)-2,2-dichloro-3-(4-chloro-3- fluorophenyl)cyclopropane- l-carboxylic acid (C93; 0.049 g, 0. 172 mmol) and the freshly prepared intermediate aniline hydrochloride In ethyl acetate ( 1 mL) were added pyridine (0.074 mL, 0.69 mmol) followed by a 50% solution of 2,4,6-tripropyl- l,3,5,2,4,6- trioxatriphosphinane 2,4,6-trioxide (0.103 mL, 0.345 mmol) in ethyl acetate, and the resuiting light-orange solution was warmed to 50 °C and stirred for 16 hours. The reaction mixture was concentrated under a stream of nitrogen, and the resulti ng red, viscous oil was purified by automated flash chromatography (silica gel ; 0->50% ethyl acetate In hexanes). The resulting glassy oil was dissolved / suspended in diethyl ether (1 mL) and treated with hexanes until turbid (few drops) . The solvents were evaporated under a stream of nitrogen to give the title compound as a light tan solid (0.081 mg, 85%) .

The following compounds were prepared in like manner to the procedure outlined in Example 83 :

6~Chloro~3~((l ? _f 3 ?)-2 _J ,2~dschSoro~3~(3~chforo~4~fSuorophenyS}cycfopropane~l- carboxamsdo)-i¥~ ~diff uc5rophenyS}~2~fluorobenzamide (F 1464)

Isolated as a white solid (0.036 g, 61%) . 6-ChSoro-3~((ll?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenvl)cycopropane~l~ carbo¾a idG)~2~f!uorG~ ™pheny!benza iide (F1466)

Isolated as a white solid (0.076 g, 77%).

~(3-Amino-2,4-diffuor>phenv ^, !)-6~chforo~3~{{lJ? _f 3^)-2,2-dichforo~3~(3-chf >ro~ 4-fluorophenyf)cvclopropane~l~carbo amido)~2~fSuorob8nramide (F1508)

Isolated as a white solid (0.028 g, 41%).

6-ChSoro-3~((ll?,3l?)~2 _f 2~dich!oro~3~{3~chforo~4-f!uorophenyl)cycopropane~l~ carbo3amsdo)-i¥-ethy!-2-fluorobenxamsde (F2071)

Isolated as a white solid (0.024 g, 55%).

6~Chloro~3~((l^ _f 3^}-2,2~dschSoro-3~(3~chforo-4~fSuorophenyS}cycfopro carboxamsd3}-2-fiuoro-/y-(2,2,2-trif!u3roethy}benzamide (F2072)

Isolated as a white solid (0.030 g, 70%).

6~Chloro~3~((l^ _f 3^}-2,2~dschSoro-3~(3~chforo-4~fSuorophenyS}cycfopropa n8~l- carboxamsdo)-2~fluoro~¥~{2,2,3 _f 3 _f 3~pentaffuoropropyf)benzamid8 (F2073)

Isolated as a white solid (0.038 g, 77%).

-ChSoro-i¥~(3-chforopropyf )-3~({ l ,3l?)~2 _f 2~dich!oro~3-(3~chSoro-4-

Isolated as a white solid (0.028 g, 76%).

E ample 84; Preparation of fraiis~2~chSoro~5-{2 _f 2~dichforo~3-(3,5~

dich!orophenyt)cyc!opropane-l-carboxamido}-3-fiuorobenzoi c acsd (C282);

To a stirred solution of trans-2, 2-dichloro-3-(3,5-dichlorophenyl)cyclopropane-l- carboxylic acid (CI in U.S. Patent Application Publication US20160304522A1 ; 0.25 g, 0.83 mmol) in ethyl acetate (15 mL) were added 5-amino-2-chloro-3-fluorobenzoic acid (C196; 0.15 g, 0.83 mmol), 2,4,6-tripropyl-l,3,5,2,4,6-trioxatnphosphinane 2,4,6- trioxide (50% solution in ethyl acetate; 1 mL, 3.34 mmol), and pyridine (0.8 mL, 4.18 mmol). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was filtered through a pad of Celite ^® , and the pad was washed with ethyl acetate. The filtrate was concentrated under reduced pressure. The title compound was isolated as a pale yellow Iiquid (0.4 g) which was used in the next step without further purification : ESIMS m/z 468.90 ([M-H]-).

Example 85; Supercritical Fluid Chromatography (SFC) purification of (1^,3^)- 2 _? 2-dichioro~3~(3 _f 4 _f 5~trifiuoropheny!)cyciopropane~l~carboxy!ic acid (C2S3) and {lS _? 3S)~2 _f 2~dichioro-3~(3 _f 4,5~tnf!uorophenyi)cyciopropane~l~carboxyiic acid (C2S4)

Racemic (trans)-2,2-dichloro-3-(3,4,5-trifluorophenyl)cyclopropane-l -carboxylic acid (U.S. Patent Application Publication US20160304522A1 (C228); 2.29 g) was separated by Preparative SFC on a Chlralpak IE column (30 x 250 mm, 5 μηη) using 90:10 CO2,/0.5% isopropyiamine in isopropanoi and 100,0 bar back pressure to give the title compounds: (C283) (0,9 g, peak 2); (C284) (0.9 g, peak 1).

The following compounds were prepared In like manner to the procedure outlined in Exampie 85:

(U?,3J?)~2 _f 2~DichSoro-3-{3 _f 4~difSuorophenyl)cvc!opropan8~l-carbo3ylic acid

(1.5 g, peak 2): H NMR (300 MHz, DMSG- e) δ 13,36 (br s, 1H), 7.58 (ddd, J = 2.0, 7.7, 11.9 Hz, 1H), 7,45 (td, J = 8.6, 10,6 Hz, 1H), 7.32 (br d, J = 1.8 Hz, 1H), 3,50 - 3,40 (m, 2H); ESIMS m/z 264.81 ([M-H] ^" ). The title compound was obtained via resolution of racemic frans-2,2-dichloro-3-(3,4-difluorophenyl)cyclopropane-l-carb oxylic acid (U.S. Patent Application Publication US20160304522A1 (C421)).

(lS,3S)~2 _f 2~Dschforo-3~(3 _f 4~dif uorophenyS}cyclopropane-l~carbo3ySic acid

(1.5 g, peak 1): *H NMR (300 MHz, DMSO-de) δ 13,36 (br s, 1H), 7,58 (ddd, J = 2.0, 7.8, 11.8 Hz, 1H), 7.45 (td, J = 8.4, 10.6 Hz, 1H), 7.36 - 7,26 (m, 1H), 3,52 - 3,42

(m, 2H); ESIMS m/z 264.81 ([M-H] ). The title compound was obtained via resolution of racemic trans-2, 2-dich!oro-3-(3,4-difluoropheny!)cyciopropane-l-carboxy!ic acid (U.S.

Patent Application Publication US20160304522A1 (C421)).

Example 86; Preparation of /¥~{5~amino~2 _f 4~difiuorophenyi}~2 _f 2~

difiuoroacetamide (C287)

2,2-Difluoroacetic anhydride (2 mL, 2,87 rrtmoi) was added to 2,4-difluoro-5- nitroaniline (0.5 g, 2,87 mmo!) in a 40 mL glass vial with stir bar. The reaction mixture was stirred overnight, The mixture was dried and the crude product was dissolved in ethyl acetate (10 mL). Palladium (5% on carbon, 500 mg) was added to the vial, and the mixture was stirred overnight under a baiioon of hydrogen. The mixture was filtered through a pad of Ceiite ^® , rinsed with ethyl acetate and the solvent removed under reduced pressure. The title compound was isolated as a brown solid (0.354 g, 50%): ^l H NMR (400 MHz, CDC ) δ 7,98 (s, 1H), 7,79 (dd, J = 9,2, 7,7 Hz, 1H), 6,87 (t, J = 10,3 Hz, 1H), 6.02 (t, J - 54,2 Hz, 1H), 3,71 (s, 2H); ¹⁹ F NMR (376 MHz, CDC!;,) δ -125,72, -134,01, -140,54, -140,54; ESIMS m/z 223 ([M + H]÷).

The following compounds were prepared In like manner to the procedure outlined In Example 86:

i¥-(S-Amino-2 _f 4-dif!uorophenv'S)-2 _i .2,2-tnfluoroacetamide (C288)

Isolated as a grey solid (0.383 g, 50%): *H NMR (400 MHz, CDCb) δ 7.93 (s, 1H), 7.74 (dd, J - 9.0, 7.7 Hz, 1H), 6.89 (t, J - 10.3 Hz, 1H), 3,35 (s, 2H); ¹⁹ F NMR (376 MHz, CDCb) δ -75.74, -133.08, -140.33; ESIMS m/z 241 ([M + H] ⁺ ).

i¥-(5~Amino~2 _f 4~difuorophe

Isolated as a brown solid (1.06 g, 90%); ^l H NMR (400 MHz, CDCb) δ 7.82 (dd, J = 9,4, 7,9 Hz, 1H), 7,20 (s, 1H), 6.80 (t, J = 10.5 Hz, 1H), 3,63 (s, 2H), 2.19 (s, 3H); ¹⁹ F NMR (376 MHz, CDCb) δ -136.64, -141.55; ESIMS m/z 187 ([M÷H] ^" ),

f-(2-Amino-3-fSuorophenv!)acetamide (C290)

Isolated as a pale solid (1.07 g, 90%): ^l H NMR (400 MHz, DMSO-de) δ 9.26 (s, 1H), 7.07 (dt, J = 8,0, 1.3 Hz, 1H), 6.87 (ddd, J = 11.0, 8,2, 1,4 Hz, 1H), 6,52 (td, J = 8.1, 5.9 Hz, 1H), 4.84 (s, 2H), 2.05 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -133,10, N-(2-amino-S-fluorophenvl)acetam!de (C29I)

Isolated as a brown solid (1,06 g, 90%): ri NMR (400 MHz, DMSO-cfe) δ 9.13 (s, IH), 7.22 (dd, J - 10.7, 2.8 Hz, IH), 6.82 - 6.60 (m, 2H), 4.79 (s, 2H), 2.05 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-c5) δ -127,99.

i¥~(5~Amino-2~fSuorophenyl)acetaniide (C292)

Isolated as a pale solid (1.07 g, 90%): *Η NMR (400 MHz, DMSO-ce) δ 9.40 (s, IH), 7.13 (dd, J - 6.9, 2.8 Hz, IH), 6.84 (dd, J - 10.9, 8.7 Hz, IH), 6.33 - 6.17 (m, IH), 4.93 (s, 2H), 2.04 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -141.63.

i¥-(3~Amino~4~f!uorophenvf)acetamide (C293)

Isolated as a pale solid (1.08 g, 90%): ^l H NMR (400 MHz, DMSO-c/e) δ 9.66 (s, IH), 7.11 (dd, J = 8.5, 2.6 Hz, IH), 6.85 (dd, J = 11.3, 8.7 Hz, IH), 6.63 (ddd, J = 8.7, 4.0, 2.6 Hz, IH), 5.11 (s, 2H), 1.98 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-ce) δ -141,04, i¥-(2-Amino-4 _f 6-dif!uorophenv'S)acetamide (C294)

Isolated as a brown solid (1.06 g, 90%): ^l H NMR (400 MHz, DMSO-c/e) δ 8.89 (s, IH), 6.35 - 6.20 (m, 2H), 5.51 (s, 2H), 2,00 (s, 3H); ¹⁹ F NMR (376 MHz, DMSOcfe) δ -113,54, -113,56, -117,69, -117,71,

i¥-(2-Amino-3 _f S-dif!uorophenv'S)acetamide (C295)

Isolated as a black solid (1.1 g, 90%): *H NMR (400 MHz, DMSQ~cfe) δ 9.31 (s, 1H), 7.19 (dt, J = 10.8, 2.3 Hz, 1H), 6.90 (ddd, J = 11.5, 8.8, 2.9 Hz, 1H), 4.78 (s, 2H), 2.07 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-tfe) δ -126,81, -129.59.71.

W-(2-Amino-4,5-d!f uorophen

Isolated as a gray solid (1.06 g, 90%): ^l NMR (400 MHz, DMSO-cfe) δ 9.11 (s, 1H), 7.31 (dd, J = 12.5, 8.8 Hz, 1H), 6.65 (dd, J = 13,0, 8.1 Hz, 1H), 5.07 (s, 2H), 2,03 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-tfe) δ -142.62 (d, J = 24.2 Hz), -153.98 (d, J = 23.7 Hz).

i¥-{2~Amino~4 _f 6~diffuorophen ~2 _f 2,2~tnf!uoroacetamide (C297)

Isolated as a brown solid (1,06 g, 90%): NMR (400 MHz, DMSO-tfe) δ 14.52 (s, 1H), 7,67 - 7.18 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -63.00, -113.06, -123.55. W-{6-Amino-2 _f 3-d!f uorophenyS -2 _? 2 _? 2-tnfluoriacetam!de (C298)

Isolated as a brown solid (0,34 g, 50%): NMR (400 MHz, DMSO-ds) δ 14.51 (s, 1H), 7,51 (ddt, J = 19,3, 13,2, 7.1 Hz, 2H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -63.06, -147.20, -153.46 (d, J = 21.0 Hz).

i¥-{2~Amino~4 _f 5~diffuorophenyS}~2 _f 2,2~tnf!uoroacetamide (C299)

Isolated as a brown solid (0,38 g, 50%): NMR (400 MHz, DMSO-ds) δ 14.30 (s, 1H), 7,84 (s, 2H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -62.94, -62.95, -139.23, -142.16, W-{2-Amino-3 _f 5-d!f uorophenyS)-2 _? 2 _? 2-tnfluoriacetam!de (C300)

Isolated as a gray solid (0.38 g, 50%) : *H NMR (400 MHz, DMSO-c/e) δ 14,54 (s, IH), 7.40 (d, J = 8,2 Hz, IH), 7,31 (t, J = 10.6 Hz, IH); ¹⁹ F NMR (376 MHz, DMSO-de) δ -63.00, -113.06, -123.56.

i¥-{2~Amino~S~f!uorophen¾ff )-2 _J ,2 _f 2~trifSuoroacetamide (C301)

Isolated as a pale solid (0,39 g, 50%) : H NMR (400 MHz, DMSO-de) δ 12,89 (s, IH), 7.68 (ddd, J = 12.2, 9.2, 3.5 Hz, 2H), 7.40 (td, J = 9.3, 2,4 Hz, IH); ¹⁹ F NMR (376 MHz, DMSO-tfe) δ -62.70, -118.54.

i¥-{5~Amino~2~f!uorophen¾ff )-2 _i 2 _f 2~trifSuoroacetamide (C302)

Isolated as a black solid (0.4 g, 50%) : *H NMR (400 MHz, CDC ) δ 8,01 (s, IH), 7.66 (dd, J = 6,5, 2,8 Hz, IH), 6.94 (dd, J = 10.5, 8.8 Hz, IH), 6.45 (ddd, J = 8,8, 4,2, 2.8 Hz, IH); ⁱ⁹ F NMR (376 MHz, CDCb) δ -75.79, -144.06.

W-{3-Amino-4-f!uorophenv!)-2 _f 2 _f 2-tnfSuoroacetam!de (C303)

Isolated as a gray solid (0,42 g, 50%) ; ¹ H NMR (400 MHz, CDCb) δ 7,72 (s, IH), 7.22 (dd, J = 7,8, 2,6 Hz, IH), 6.97 (dd, J = 10.5, 8.7 Hz, IH), 6.69 (ddd, J = 8,7, 3,9, 2.7 Hz, IH), 3.86 (s, 2H); ¹⁹ F NMR (376 MHz, CDCb) δ -75,74, -136.95.

W-{3-Amino-S-f!uorophenv!)-2 _f 2 _f 2-tnfSuoroacetam!de (C304)

Isolated as a gray solid (0.40 g, 50%) ; H NMR (400 MHz, CDC ) δ 7,71 (s, 1H), 6.80 (td, J = 2,0, 0.7 Hz, 1H), 6.63 (dt, J = 9.9, 2.1 Hz, 1H), 6.25 (dt, J = 10.3, 2.1 Hz, 1H), 3.90 (s, 2H); ¹⁹ F NMR (376 MHz, CDG ₃ ) δ -75,79, -110.83.

W-{2-Amino-3-fSuorophenyi}- -tnf!uoroacetamide (C305)

Isolated as a brown solid (0,39 g, 50%) ; Ή NMR (400 MHz, DMSO-cfe) δ 14.36 (s, 1H), 7.51 (s, 1H), 7.40 (td, J = 8.1, 4,8 Hz, 1H), 7,20 (t, J = 9.5 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSQ-de) δ -62.86, -127.62.

W-{2-Amino-6-fSuorophenyi)-2j2,2-tnf!uoroacetamide (C306)

Isolated as a gray solid (0.4 g, 50%) ; ^"! H NMR (400 MHz, DMSO-de) δ 14.33 (s, 1H), 7.60 - 7,43 (m, 1H), 7,44 - 7.32 (m, 1H), 7.20 (d, J = 9.0 Hz, 1H); ¹⁹ F NMR (376 MHz, DMSO-tfc) δ -62,74, -62,75, -62,87, -127,60.

Example 87; Preparation of f-{3-am!no-2,4-dif!uorophenyl)-2,2- diff uoroacetamide hydrochloride (C307)

To a solution of tert-butyl-/V-(3-amino-2,6-difluoro-phenyl)-/V-tert- butoxycarbony!-carbamate (C1S2) (1,0 g, 2.90 mmoi) in dichloromethane (30 mL) was added 2,2-difluoroacetlc anhydride (2.5 mL, 3.59 mmol). The reaction mixture was stirred overnight at room temperature and then concentrated under reduced pressure. The crude product was dissolved in dichloromethane (30 mL), Hydrochloric acid (4 M in dioxane, 7,25 mL) was added to the solution, and the reaction mixture was stirred at room temperature for 6 hours. The precipitate that formed was fiitered and washed with cold dichloromethane, The title compound was isolated as a white solid (0,74 g, 98%) ; *H NMR (400 MHz, DMSO-t e) δ 10,47 (s, 1H), 6.91 (ddd, J - 10.7, 8.9, 1.9 Hz, 1H), 6.76 (td, J = 8.5, 5, 5 Hz, 1H), 6,44 (t, J = 53.5 Hz, 1H), 5.09 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -125.40, -133.15 (d, J = 14.3 Hz), -138.66 (d, J = 14.4 Hz).

The following compounds were prepared in like manner to the procedure outlined in J¥-{3-Amino~2 _f 4-difluorophenyf )-2,2,2~triff uoroacetamide hydrochloride (C308)

Isolated as a brown solid (0.80 g, 99%) : ^l H NMR (400 MHz, DMSQ-cfe) δ 11.09 (s, 1H), 6.95 (ddd, J = 10.7, 8.8, 1,9 Hz, 1H), 6,57 (td, J = 8.4, 5.4 Hz, 1H), 5,56 (s, 3H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -73,91, -131,57 (d, J - 15.6 Hz), -137.08 (d, J = 15,6 Hz),

~C3-A ino™2 _f 4-difluGrophenyl)acetamide hydrochloride (C309)

Isolated as a brown solid (0,60 g, 93%) : ^L H NMR (400 MHz, DMSO- fe) δ 9.55 (s, 1H), 6.91 (td, J = 8.5, 5,7 Hz, 1H), 6,83 (ddd, J = 10.7, 8,9, 1.8 Hz, 1H), 5.94 (s, 3H), 2.04 (s, 3H); ¹⁹ F NMR (376 MHz, DMSO-cfc) δ - 135,33 (d, J = 12.4 Hz), -140.18 (d, J - 12,3 Hz),

E ample 88; Preparation of fert-butyi (4~chioro~2-f!uoro-3~({4- fiuoropheny!)carbamoyi)phenyi)carbamate (C310)

To a solution of 3-((ferf-butoxycarbonyl)amino)-6-chloro-2-fluorobenzoic acid (C318; 85,0 mg, 0,293 mmoi) and 4~fluoroaniline (34.2 mg, 0.308 mmol) in ethyl acetate (2,5 mL) were added pyridine (0.094 mL, 0,880 mmoi) followed by 2,4,6- tripropyi-l,3,5,2,4,6-trloxatriphosphinane 2,4,6-trioxide (0.35 mL, 0.587 mmol), and the resuiting light-yellow solution was warmed to 50 °C and stirred for 8 hours. The reaction mixture was concentrated under a stream of nitrogen, and the resulting red-orange oil was purified by automated fiash chromatography (silica gel; 0~ 65% ethyl acetate In hexanes), The title compound was isolated as a white solid (0,075 g, 66%) : mp 145 - 148 °C; *H NMR (400 MHz, DMSO-de) δ 10,83 (s, 1H), 9.32 (s, 1H), 7.80 - 7.64 (m, 3H), 7,36 (dd, J = 8.8, 1.4 Hz, 1H), 7,27 - 7.16 (m, 2H), 1.47 (s, 9H); ¹⁹ F NMR (376 MHz, DMSO-rfe) δ -118.08, -124,58; ESIMS m/z 381 ([M-H] ).

The following compounds were prepared in like manner to the procedure outlined in Example 88:

fert-Butyl (4-chloro-2-f!uoro-3-{pheny!carbamoy phen l)carbamate (C3i I)

Isolated as a white solid (0.085 g, 79%): mp 91 - 94 °C; NMR (400 MHz, DMSO-Λ) δ 10,76 (s, 1H), 9,31 (s, 1H), 7.74 (t, J = 8.7 Hz, IH), 7,71 - 7.66 (m, 2H), 7.42 - 7.29 (m, 3H), 7.21 - 7,06 (m, IH), 1,47 (s, 9H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -124.64; ESIMS m/z 363 ([M-H] ^~ ),

ferf-Butyf (4~chloro~3~((2,4-difluorophenyf)carbamovf}~2-

Isolated as a white solid (0.048 g, 40%): mp 136 - 139 °C; H NMR (400 MHz, DMSO-de) δ 10,66 (s, IH), 9.31 (s, IH), 7.81 (td, J = 8.9, 6,1 Hz, IH), 7,74 (t, J = 8.6 Hz, IH), 7,43 - 7.32 (m, 2H), 7.18 - 7.10 (m, IH), 1.47 (s, 9H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -113.14, -113.16, -117.72, -117.74, -124.47; ESIMS m/z 399 ([M-H] ), ferf-Buty {ferf-butoxycarbony (3-{3-((te/'t-butoxv'carbonv'!)am!no)-6-ch!oro- 2-f!uorobenzamido)-2 _? 6-difluiropheny carbamate (C3I3)

Isolated as a white solid (0.076 g, 34%); mp 83 - 88 °C; Ή NMR (400 MHz, DMSO-de) δ 10.75 (s, IH), 9.30 (s, IH), 7.88 - 7.68 (m, 2H), 7.35 (dd, J = 8.8, 1.4 Hz, IH), 7.32 - 7.23 (m, IH), 1.47 (s, 9H), 1,40 (s, 18H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ - 123,39, -124.42, -126.90; ESIMS m/z 614 ([M-2H] ).

fert-Butyl (4-chloro-3-(ethy!carbamoy!)-2-f!uorophenyS)carbamate (C314)

Isolated as a white solid (0.032 g, 34%); mp 145 - 147 ^C C; ^J H NMR (400 MHz, DMSG-efe) δ 9.21 (s, IH), 8,66 (t, J = 5,6 Hz, IH), 7,65 (t, J = 8.6 Hz, IH), 7.26 (dd, J = 8.8, 1.5 Hz, 1H), 3.25 (qd, J = 7.2, 5.5 Hz, 2H), 1.46 (s, 9H), 1.10 (t, J = 7.2 Hz, 3H); ⁱ⁹ F NMR (376 MHz, DMSO-tfc) δ -124,90; ESIMS m/z 315 ([M~H] ^" ).

ferf-Butyf {4-ch!oro-2-f!uoro-3-((2,2 _f 2-tr!f uoroethy!)carbar!ioyS}phenv }- carbamate (C3I5)

Isolated as a white solid (0.035 g, 32%): mp 177 - 180 °C; 'H NMR (400 MHz, DMSO-de) δ 9.42 (t, J = 6.2 Hz, 1H), 9,27 (s, 1H), 7.70 (t, J = 8.6 Hz, 1H), 7.31 (dd, J = 8.8, 1,4 Hz, 1H), 4,19 - 4.00 (m, 2H), 1.46 (s, 9H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ - 70,42, -124,62; ESIMS m/z 369 ([M-H] ^" ).

ferf-Butyf (4-ch!oro-2-f!uoro-3-((2,2 _f 3,3 _/ 3- pentaf!uoropropyl)carbamoyli)phenyl)-carba ate (C3I6)

Isolated as a white solid (0.047 g, 38%): mp 152 - 155 °C; ¹ H NMR (400 MHz, DMSO-de) δ 9,44 (t, J = 6,3 Hz, 1H), 9,26 (s, 1H), 7.70 (t, J = 8,6 Hz, 1H), 7,31 (dd, J = 8.9, 1,4 Hz, 1H), 4,15 (td, J = 15.7, 5,7 Hz, 2H), 1,46 (s, 9H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -83.41, -120.04, -124.47; ESIMS m/z 419 ([M-H] ^" ).

ferf-Buty {4-chSoro-3-{(3-ch!oropropy carbamoyi)-2-fluorophenyl)carbamate (C317)

Isolated as a white solid (0,032 g, 30%): mp 126 - 128 °C; ^l NMR (400 MHz,

DMSO-de) δ 9,23 (s, 1H), 8.77 (t, J = 5.6 Hz, 1H), 7.66 (t, J = 8,6 Hz, 1H), 7,28 (dd, J = 8,8, 1,4 Hz, 1H), 3,70 (t, J = 6.6 Hz, 2H), 3.40 - 3,36 (m, 2H), 1.95 (p, J = 6.6 Hz, 2H), 1.46 (s, 9H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -124,88; ESIMS m/z 363 ([M-2H] ^~ ). Example 89: Preparation of 3~({ferf-butoxycarbony!)arnino}~6~chSoro~2~ ffuorobenzoic acid (C318

To a suspension of ethyl 3-[bis(tert-butoxycarbonyl)amino]-6-chloro-2- fiuorobenzoate (C319; 7.57 g, 18.1 mmol) in a 2 : 1 mixture of tetrahydrofuran (48 mL) and water (24 mL) was added lithium hydroxide nrtonohydrate (2,28 g, 54, 3 mmol), and the resulting turbid mixture was vigorously sti rred for 16 hours at room temperature, at which point LC-MS analysis indicated only starting material and the starting materia! with one of the Boc groups cleaved . The reaction mixture was diluted with methanol (25 mL) and the mixture was sti rred at room temperature for 16 hours, at which point LC- MS indicated full consumption of the ester starting material . The organics were evaporated under reduced pressure, and the residual aqueous mixture (cream colored precipitate) was diluted with ethyl acetate (~200 mL) and vigorously stirred while the H was adj usted (6 - 7) by the dropwise addition of 1 N aqueous hydrogen chloride (~35 mL) . The phases were separated and the aqueous phase was extracted with additional ethyl acetate (2 x 50 mL) . The combined organic extracts were washed successively with water ( 100 mL) and brine (2 x 75 mL), dried over sodium sulfate, filtered, and concentrated . The title compound was isolated as a colorless, glassy solid ( 1.465 g,

27%) : mp 79 - 84 °C; ^"! H NMR (400 M Hz, DMSO-d ₆ ) δ 9.12 (s, 1 H), 7.58 (t, J = 8.6 Hz, 1H), 7.21 (dd, J = 8.8, 1.4 Hz, 1H), 1.46 (s, 9H) ; ¹³ C NMR ( 101 MHz,DMSO-d ₅ ) δ 170,20, 163,68, 152.78, 151 , 13, 148 ,66, 125.75, 125,63, 124, 53, 124, 50, 123.63, 79.62, 59,64, 27.90, 20.65, 13.99; ¹⁹ F NMR (376 MHz, DMSO-cfe) δ

-124.86; ESIMS m/z 288 ([M-H] ^" ) ,

Example 90: Preparation of ethyl 3~[bis{ferf~butoxycarbonyS}amino]~6~ch!oro~ 2~ffuorobenzoate (C3

To a solution of ethyl 3-amino-6-chloro-2-fluorobenzoate (€320; 8, 5 g, 39.1 mmol) In Λ/,/V-dimethylformamide (32, 5 mL) were sequentially added added N,N- dimetby! pyridln-4-amme (0,239 g, 1 ,95 mmol), W-ethyl-W-isopropylpropan-2-amine (20,4 mL, 117 mmol), and di-tert-butyl dicarbonate (25,6 g, 117 mmol ; added i n portions), and the resulting light yellow solution was sti rred at room temperature for approximately 16 hours. The reaction mixture was treated with additional di -tert-butyl dicarbonate (3.00 g, 13.7 mmol), sti rred for 3 hours at room temperature, and partitioned between ethyl acetate (200 mL) and 5% aqueous solution of sodi um bicarbonate (600 mL) . The phases were separated, and the aqueous phase was extracted with diethyl ether (150 mL) . Each of the organic extracts was washed with water (ethyl acetate: 3 x 200 mL; diethyl ether; 2 x 100 mL) , The extracts were combined, dried over sodium sulfate, filtered, and concentrated to a viscous, red oil . The crude oi l was purified by automated flash chromatography (Si lica gel ; 0-^30% ethyl acetate In hexanes) to give the title compound as viscous, gold oil which slowly sol idifies upon standing ( 12.55 g . 77%) ; mp 91 - 95 °C; *H NMR (400 MHz, CDC ) δ 7,25 - 7.13 (m, 2H), 4.45 (q, J = 7.2 Hz, 2H), 1.45 - 1.36 (m, 21H) ; ¹³ C NMR ( 101 MHz, CDCb) δ 162.51, 156.15, 153.60, 150.19, 131.43, 131 ,38, 131.19, 131.17, 126.73, 126.60, 125.14, 125.10, 123.16, 122.97, 83 ,74, 62,41, 27.81, 14, 11 ; ¹⁹ F NMR (376 MHz, CDCb) δ - 119.43.

Example 91 : Preparation of ethy! 3-amino-6-ch!oro-2-f!uorobenzoate (C320)

To a solution of 4-chioro-2-fiuoroanill ne ( 11 g, 76 mmol) in anhydrous tetrahydrofuran ( 151 mL) cooled to -76 °C was added butyilithium (31.7 mL, 79 mmol) as a 2.5 M solution i n hexanes at a rate which maintained the temperature between below -68 °C, and the resulting greenish-brown solution was stirred at -75 °C for 45 minutes, The heterogeneous brown reaction mixture was treated with a tetrahydrofuran sol ution (50 mL) of l,2-bis(chiorodimethylsiiyi)ethane ( 17,24 g, 80 mmol) at a rate which maintained the temperature between -68 and -75 °C. Following the addition, the resulting brown solution was sti rred at -75 °C for 75 minutes.

The resulting brown solution was treated with butyilithi um (31.7 mL, 79 mmol) at a rate which maintained the temperature below -70 °C, and the resulting solution was sti rred at -74 ^C C for 30 mi nutes. The cooling bath was removed and the reaction solution was allowed to slowly warm to 15 °C over approximately a 2-hour period.

The sol ution was cooled to -72 °C and treated dropwise with butyilithium (31 ,7 mL, 79 mmol) at a rate which mai ntained the temperature below -70 °C. After stirring for 60 minutes at -74 °C, the resulting amber-brown solution was treated with ethyl carbonochloridate ( 10.66 g, 98 mmol) dropwlse at a rate which maintained the temperature below -70 °C, and the resulting dark solution was allowed to slowly warm to room temperature as the dry ice was consumed .

The resulting heterogeneous mixture (tan ppt) was cooled to 0 °C and quenched by the cautious addition of 3 N aqueous hydrogen chloride ( 140 mL, 0,42 mmol) . The ice bath was removed and the resulting dark sol ution was stirred at room temperature for 60 minutes. The pH was adj usted to ~8 by the careful addition of solid sodium carbonate (~28 g) and the mixture was extracted with ethyl acetate (3 x 150 mL) . The combined extracts were washed with brine (3 x 100 mL), dried over sodium sulfate, filtered, and concentrated to a dark oil . The crude oil was purified by automated flash chromatography (silica gel ; 0-3>30% ethyl acetate i n hexanes) to give the title compound as a light-orange oil (8,96 g, 54%) : Ή NMR (400 MHz, CDC ) δ 6.97 (dd, J = 8.6, 1.5 Hz, 1 H), 6.73 (t, J = 8.9 Hz, 1H), 4.43 (q, J = 7, 1 Hz, 2H), 3,84 (s, 2H), 1.40 (t, J = 7,2 Hz, 3H) ; ¹³ C NMR ( 101 MHz, CDC! ₃ ) δ 163.49, 149,38, 146,94, 133.85, 133.73, 125.36,

125.32, 122.35, 122.18, 119.48, 119 ,44, 117,95, 117.90, 62.19, 14.14; ¹⁹ F NMR (376 MHz, CDCI ₃ ) δ - 134.47; EIMS m/z 217.

Example 92: Preparation of /¥-(3-amino-2,6-d!ch!oropheny }acetamide (C321)

Step 1 : Preparation of fert-butyi (3-acetamido-2,4'

dich!oropheny carbamate. 3-Acetamido-2,4-dichiorobenzolc acid ( 1 g, 4.03 mmol) was added portionwise to a stirred solution of diphenyiphosphoryi azide ( 1.47 g, 5,34 mmol), and triethylamine (0.54 g, 5,34 mmol) in anhydrous tert-butanol (25 mL) , The resulting gold solution was heated at 80 °C for 1 hour, then cooled and quenched with water (20 mL) , The resulting aqueous mixture was extracted with ethyl acetate (2 x50 mL) and washed with saturated aqueous sodium bicarbonate solution (50 mL) and saturated aqueous sodium chloride sol ution (50 mL) , The organic extracts were dried over anhydrous magnesi um sulfate, fiitered and concentrated under vacuum on a rotary evaporator. Purification by flash silica gel column chromatography using 0-30% ethyl acetate in hexanes as eluent gave the title compound as a white solid (0.72 g, 44%) : H NMR (400 MHz, CDC ) δ 8,02 (d, J - 9.1 Hz, 1 H), 7.32 - 7,25 (m, 2H), 6,96 (s, 1H), 2, 23 (s, 3H), 1, 54 (s, 9H) ; ESIMS m/z 320 ([M + H] ⁺ ) .

Step 2: Preparation of i¥~(3~amino~2,6~dichforophenyi)ac8tamid8, 4 M Hydrogen chloride in 1,4-dioxane (2.8 mL, 11.3 mmol) was added dropwise to a stirred sol ution of fert-butyl (3-acetamido-2,4-dichlorophenyl)carbamate (0.72 g, 2,25 mmol) In dichloromethane (5 mL) , The resulting suspension of sol id was sti rred for 11 hours at 23 °C and then concentrated under vacuum on a rotary evaporator. The resulting crude product was slurried in dichloromethane (2 mL) and treated with triethylamine until a sol ution formed (~ 0,3 mL) . Purification by silica gel flash chromatography usi ng 0- 100% ethyl acetate in hexanes as eluent provided the title compound as a white solid, (0,45 g, 87%) : Ή N MR (400 MHz, DMSO- e) δ 9,60 (s, 1H), 7.13 (d, J = 8,8 Hz, 1H), 6, 73 (d, J = 8.8 Hz, 1 H), 5.54 (s, 2H), 2,02 (s, 3H) ; ¹³ C N MR (101 MHz, DMSO-cfc) δ 168,34, 145, 19, 133.52, 127,82, 119 ,20, 117.75, 114,48, 22,92; ESIMS m/z 220 ([Μ + ΗΓ) ,

 2H), 1.28 (t, J = 7.2 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -109.55; ESIMS m/z 307,12 ([M + H] ⁴ ),

5-Amino-2-chSoro-W-(2,2-dif!ujro-2-phenyiethv'S)ben2:amsde (C325)

Isolated as a brown solid (0.22 g, 37%): mp 109 - 111 °C; ^l H NMR (400 MHz, DMSO-de) δ 8.71 (t, J = 6.4 Hz, 1H), 7,61 - 7.46 (m, 5H), 7.03 (d, J = 8,8 Hz, 1H), 6.57 (dd, J = 2.8, 8.4 Hz, 1H), 6.50 (d, J = 2,8 Hz, 1H), 5,38 (s, 2H), 4.00 - 3.90 (m, 2H); ESIMS m/z 311,16 ([M + H] ⁴ ),

5-Amino-2-chSoro-W-(2-ox3propyi}benzamide (C326)

Isolated as an off-white solid (0.2 g, 57%); mp 118 - 120 °C; *H NMR (400 MHz, DMSO-de) δ 8,54 (t, J = 5.6 Hz, 1H), 7,06 (d, J = 8.8 Hz, 1H), 6.66 (d, J = 2.4 Hz, 1H), 6.59 (dd, J = 2,4, 8.4 Hz, 1H), 5.42 (s, 2H), 3.98 (d, J = 5.6 Hz, 2H), 2.12 (s, 3H); ESIMS m/z 227,30 ([M + H] ⁴ ),

5-Am!no-2-chloro-W-(2-oxobut¥!)benzam!de (€327)

Isolated as an off-white solid (0,25 g, 26%); mp 91 - 93 ^C C; H NMR (400 MHz, DMSO-de) δ 8,52 (t, J = 5,6 Hz, 1H), 7,06 (d, J = 8.4 Hz, 1H), 6.66 (d, J = 2.8 Hz, 1H), 6.59 (d, J = 2,4, 8.8 Hz, 1H), 5.42 (s, 2H), 3.99 (d, J = 5.8 Hz, 2H), 2.49 - 2.41 (m, 2H), 0.96 (t, J =7.2 Hz, 3H); ESIMS m/z 241.06 ([M + H] ^"1" ).

5-Amino-2-chloro-W-(4-meth¥!-2-oxopentyi)ben2:a!T!!de (C328)

Isolated as an off-white solid (0.2 g, 23%); mp 115 - 117 ^C C; ^J H NMR (400 MHz, DMSO-de) δ 8.50 (t, J = 5.6 Hz, 1H), 7,06 (d, J = 8.4 Hz, 1H), 6.66 (d, J = 2.8 Hz, 1H), 6.59 (dd, J = 2,4, 8.8 Hz, 1H), 5.43 (s, 2H), 3.97 (d, J = 6.0 Hz, 2H), 2.36 (d, J = 6,8 Hz, 2H), 2,13 - 1.99 (m, 1H), 0.88 (d, J = 6,4 Hz, 6H); ESIMS m/z 269.06 ([M + H] ⁺ ). 5-Am!no~2~chSoro~i¥~(2~03o~2~pheny!ethyl)ben2

Isolated as an off-white soiid (0.06 g, 17%): mp 132 - 134 °C; ^X H NMR (400 MHz, DMSO-fe) δ 8.54 (t, J = 5.6 Hz, 1H), 8.03 (d, J = 7.2 Hz, 2H), 7.70 - 7,66 (m, 1H), 7.59 - 7.54 (m, 2H), 7.07 (d, 3 - 8.4 Hz, 1H), 6.73 (d, J - 2.8 Hz, 1H), 6.60 (dd, J = 2.8, 8.4 Hz, 1H), 5.42 (s, 2H), 4.71 (d, J = 6.0 Hz, 2H); ESI S m/z 289.14 ([M + H] ⁺ ), 5-Amino~2~chSoro~i¥~(2 _f 2~dif uoropropyS)~3~fluorobenzam!de (C330)

Isolated as an off-white soiid (0.2 g, 63%); mp 107 - 109 ^C C; ^l NMR (400 MHz, DMSO-de) δ 8.80 (t, J = 6.4 Hz, 1H), 6,53 (dd, J = 2.8, 12.0 Hz, 1H), 6.43 (d, J = 1.6 Hz, 1H), 5,73 (hr s, 2H), 3.69 - 3.60 (m, 2H), 1.63 (t, J = 18.8 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-Gfe) δ -93,66, -115.77; ESIMS m/z 267.08 ([M+H] ^"1" ),

5-Am!no-2-chloro-W-(2 _? 2-d!fluorobutyS)-3-fluoriben2:am!de (C33i)

Isolated as an off-white solid (0,19 g, 53%); mp 79 - 81 °C; ^! H NMR (400 MHz, DMSO-tfe) δ 8.81 (t, J = 6.0 Hz, 1H), 6.56 (dd, J = 2,8, 12.4 Hz, 1H), 6.45 - 6.42 (m, 1H), 5.72 (br s, 2H), 3.70 - 3,60 (m, 2H), 1.97 - 1.86 (m, 2H), 0.98 (t, J = 8.0 Hz, 3H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -103.09, -115.77; ESIMS m/z 281.14 ([M + H] ⁺ ).

Ethy! 3~{5~arnino~2~chloro~3~ffuorobeniarnido)~2 _f 2~difSuoropropanoate (C33 )

Isolated as an off-white solid (0.12 g, 19%); mp 83 - 85 °C; *H NMR (400 MHz, DMSO-cfc) δ 8.92 (t, J - 6.4 Hz, 1H), 6.54 (del, J - 2.4, 11.6 Hz, 1H), 6.42 - 6.40 (m, 1H), 5.76 (br s, 2H), 4.28 (q, J = 7.2 Hz, 2H), 3.95 - 3.85 (m, 2H), 1.28 (t, J = 6,8 Hz, 3H); ⁱ⁹ F NMR (376 MHz, DMSO-tfc) δ -109,59, -115.63; ESIMS m/z 325.17 ([M÷H] ^~ ). 5-Amino-2-chSoro-3-f uoro-/y-(2-3xobutv }benzamide (C333)

Isolated as an off-white solid (0.14 g, 40%): mp 96 - 98 °C; ^"! H NMR (400 MHz,

DMSG-de) δ 8.65 (t, J = 6.0 Hz, 1H), 6.55 - 6.50 (m, 2H), 5.76 (br s, 2H), 4.01 (d, J = 5.6, Hz, 2H), 2,49 - 2,46 (m, 2H), 0.95 (t, J = 7.2 Hz, 3H); ¹⁹ F NMR (376 MHz, D SO- cfc) δ -115.66; ESIMS m/z 259.12 ([M + H] ⁺ ),

S-Ar!i!no-2-ch!oro-3-f!u -i¥-(4-methyh2-oxopentv }benzamide (C334)

Isolated as an off-white solid (0.32 g, 58%): mp 99 - 101 °C; ^l NMR (400 MHz, DMSO-de) δ 8.58 (t, J = 6,0 Hz, 1H), 6,54 - 6.51 (m, 2H), 5,74 (br s, 2H), 3,98 (d, J = 6.0 Hz, 2H), 2.35 (d, J = 6,8 Hz, 2H) 2.08 - 2,01 (m, 1H), 0,88 (d, J = 6.8 Hz, 6H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ -115.68; ESIMS m/z 287.15 ([M + H] ⁺ ).

5~Amino~2~chSoro-3-ffuoro~i¥~(2~c5MO-2-phenySethyf)benz: amide (C335)

Isolated as an off-white solid (0.21 g, 57%): mp 147 - 149 °C; *H NMR (400 MHz, DMSO-cfe) δ 8.67 (t, J = 5.6 Hz, 1H), 8.04 - 8.01 (m, 2H), 7,70 - 7,66 (m, 1H), 7.56 (t, J = 8,0 Hz, 2H), 6,58 - 6.52 (m, 2H), 5,76 (br s, 2H), 4,72 (d, J = 5,6 Hz, 2H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -115,29; ESIMS m/z 307.19 ([M + H] ⁺ ).

5-Am!no-2-chSoro-3-fluoro- f-(2-oxopropv )ben2:a!T!ide (C336)

Isolated as an off-white solid (0.075 g, 30%) : mp 126 - 128 °C; ^l NMR (400 MHz, DMSO-tfc) δ 8.65 (t, J = 5.6 Hz, 1H), 6.55 - 6.50 (m, 2H), 5.76 (br s, 2H), 4,01 (d, J = 6.0 Hz, 2H), 2.13 (s, 3H); ¹⁹ F NMR (376 MHz, DMSQ-c e) δ -115.66; ESIMS /z 245,03 ([M + H] ⁺ ) .

5-Amino 2-chSoro-W-(2 _f 2-dsfluoro-2-phenySethy }-3-fluor iben2:amsde (C337)

Isolated as an off-white solid (0.25 g, 60%) : mp 136 - 138 °C; ^J H NMR (400 MHz, DMSO-c s) δ 8.83 (t, J - 6.4 Hz, 1H), 7.58 - 7.49 (m, 5H), 6.51 (dd, J - 2.4, 11.6 Hz, 1H), 6,36 - 6.31 (m, 1H), 5.72 (br s, 2H), 4.01 - 3.91 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO- e) δ -98,49, -115.60; ESIMS m/z 329.17 ([M+H] ⁺ ).

Example 94; Preparation of 5-amino-2-chloro-iV-(2-oxo-2-(2,2,2- tnfiuoroethylamsnG)ethy!)ben2am!de (C33S)

To a solution of 5-amino-2-chlorobenzoic acid (0.6 g, 3.49 mmol) in

dichloromethane (10 mL) were added sequentially 2-amino-/V-(2,2,2- trifluoroethyl)acetamide (C3S0; 0.8 g, 4.20 mmol), W-(3-dimethylaminopropyl)-/V'- ethylcarbodlimide hydrochloride (2 g, 10, 5 mmol), diisopropylethyiamine (1.73 mL, 10.5 mmol), and 4-(dimethylamino)pyridine (cat,), and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure. Purification by column chromatography (silica gel 100 - 200 mesh) eluting with 5 - 10% ethyl acetate in methanol afforded the title compound as an off-white solid (0.28 g, 26%) : mp 109 - 111 °C; Ή NMR (400 MHz, DMSO-cfc) δ 8.47 (t, J = 5.6 Hz, 1H), 8.42 (t, J = 6,0 Hz, 1H), 7,05 (d, J = 8.4 Hz, 1H), 6.68 (d, J = 2.8 Hz, 1H), 6.58 (dd, J = 2.4, 8.8 Hz, 1H), 5.38 (m, 2H), 3,98 - 3,89 (m, 2H), 3.87 (d, J = 6,0 Hz, 2H); ESIMS m/z 310.15 ([M + H] ^"1" ),

The following compounds were prepared in like manner to the procedure outlined in Example 94:

5~Amino~2~chforo~/^~(3~OMO~3~{(2 _f 2 _f 2~triffuoroethyf )amino)propy!)benzamide { 3319 }

Isolated as an off-white solid (0.17 g, 15%): mp 148 - 150 °C; ^J H NMR (400 MHz, DMSQ-cfe) δ 8.56 (t, J = 6.4 Hz, 1H), 8.22 (t, J = 5.2 Hz, 1H), 7.04 (d, J = 8,4 Hz, 1H), 6.58 - 6,54 (m, 2H), 5.33 (s, 2H), 3,92 - 3.84 (m, 2H), 3,41 - 3.35 (m, 2H), 2,44 (t, J ^™ 7.2 Hz, 2H); ¹⁹ F NMR (376 MHz, DMSO-de) δ -70.71; ESIMS m/z 324.20

([M + H] ⁺ ),

5-Amino~2~chSoro~ ~(4~oxo~4~{(2 _f 2,2~tnfluoroethyS)amsno)butv ^, !)ben2amide (C340)

Isolated as an off-white solid (0.59 g, 25%): mp 136 - 138 °C; H NMR (400

MHz, DMSO-ce) δ 8.46 (t, J - 6.4 Hz, 1H), 8.22 (t, J - 5.2 Hz, 1H), 7.05 - 7.02 (m, 1H), 6.58 - 6.55 (m, 2H), 5.34 (s, 2H), 3.93 - 3.84 (m, 2H), 3.28 - 3.14 (m, 2H), 2.23 (t, J = 7,2 Hz, 2H), 1,75 - 1,68 (m, 2H); ¹⁹ F NMR (376 MHz, DMSG-cfe) δ -70.85; ESIMS m/z 338.18 ([M + H] ⁺ ).

5-Amino-2-chSoro-W-(2-oxj-2-{(3,3,3-tnf!uoropropy!)ar!i!n o)ethyS)benzamsde (C341)

Isolated as an off-white solid (0.98 g, 33%): mp 110 - 112 °C; *H NMR (400 MHz, DMSO-tfc) δ 8.39 (t, J = 6,0 Hz, 1H), 8,04 (t, J = 5,6, 1H), 7,06 (d, J = 8.4 Hz, 1H), 6.68 (d, J = 3.2 Hz, 1H), 6.58 (dd, J = 2,4, 8.4 Hz, 1H), 5.39 (s, 2H), 3.78 (d, J = 6.0 Hz, 2H), 3.35 - 3.30 (m, 2H), 2.49 - 2,39 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-ce) δ -63,98; ESIMS m/z 324.13 ([ + H] ⁺ ).

5-Am!no-2-chloro-W-(3-oxo-3-C(3 _f 3 _f 3-tnfSuoropropy am!no)propyS)ben¾am!de (C342)

Isolated as an off-white solid (0.83 g, 28%): mp 109 - 111 °C; *H NMR (400 MHz, DMSO-cfe) δ 8.23 (t, J = 5.6 Hz, 1H), 8.13 (t, J = 5.6 Hz, 1H), 7.04 (d, J = 8.4 Hz, 1H), 6.57 (d, J = 3.2 Hz, 1H), 6.56 - 6.54 (m, 1H), 5.36 (s, 2H), 3,39 - 3.34 (m, 2H), 3.30 - 3.25 (m, 2H), 2.50 - 2.31(m, 4H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -63.98; ESIMS m/z 338,15 ([M + H] ⁺ ).

5-Am!no-2-chloro-W-(4-oxo-4-{(3 _f 3 _f 3-tnfSuoropropy a^ino)butvl)benzamide (C343)

Isolated as an off-white soiid (0,51 g, 17%): mp 121 - 123 °C; ^L NMR (400 MHz, DMSO-cfe) δ 8.24 (t, J = 6,0 Hz, 1H), 8,02 (t, J = 5,2 Hz, 1H), 7,04 (d, J = 8.8 Hz, 1H), 6.57 - 6,55 (m, 2H), 5.36 (s, 2H), 3,30 - 3.24 (m, 2H), 3.18 - 3.13 (m, 2H), 2,50 - 2,35 (m, 2H), 2,13 (t, J = 7,2 Hz, 2H), 1.73 - 1.65 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -63.91; ESIMS m/z 352.41 ([M + H] ⁺ ).

5~Amino~2-chloro~i¥-(2~ ~trifluoroacetamido)ethyS}ben_5:amsde (C344)

Isolated as an off-white solid (0.32 g, 18%): mp 157 - 159 °C; *H NMR (400 MHz, DMSO-cfe) δ 9.38 - 9.35 (m, 1H), 8.38 - 8,36 (m, 1H), 7.06 - 7,03 (m, 1H), 6.60 - 6.56 (m, 2H), 5.34 (s, 2H), 3.37 - 3.28 (m, 4H); ⁱ⁹ F NMR (376 MHz, DMSO-de) δ - 74.47; ESIMS m/z 310.15 ([M + H] ⁺ ).

5~Amino~2~chloro~i¥- ~(2 _f 2 _f 2~trifluoroacetamido)propvf}benzamide (C345)

Isolated as an off-white solid (0.80 g, 28%): mp 105 - 107 °C; ^L h NMR (400 MHz, DMSO-cfe) δ 9.38 - 9.36 (m, 1H), 8.25 (t, J = 5,6 Hz, 1H), 7,04 (dd, J = 2.0, 7.2 Hz, 1H), 6.59 - 6.56 (m, 2H), 5.35 (s, 2H), 3.29 - 3.17 (m, 4H), 1.74 - 1.67 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-cfe) δ -74.42; ESIMS m/z 324.24 ([M + H] ⁺ ).

5~Aniino~2~chloro~i¥-{4~(2 _f 2 _f 2~trifluoroacetamido)butyS)ben¾amide (C346)

Isolated as a pale ye!iow gummy solid (0,98 g, 34%): *H NMR (400 MHz, DMSO-/ ₆ ) δ 9.44 (t, J = 5.6 Hz, 1H), 8.25 (t, J = 5,6 Hz, 1H), 7,04 (d, J = 8.4 Hz, 1H), 6.57 (d, J = 2.8 Hz, 1H), 6.55 - 6,54 (m, 1H), 5,37 (s, 2H), 3.22 - 3,15 (m, 4H), 1,57 - 1.45 (m, 4H); ¹⁹ F NMR (376 MHz, DMSG-d ₆ ) δ -74.36; IR 749,91 cm ^"1 (C-Ci stretching); ESIMS m/z 338,37 ([M + H] ⁺ ),

5-Amino~2~chSoro-i¥~(2~(2 _f 2,3 _f 3 _f 3~pentafluoropropanamsdo}ethyS}b8n :am!de

Isolated as an off-white solid (0,97 g, 46%): mp 150 - 152 °C; ^X H NMR (400 MHz, DMSO-ce) δ 9.48 (t, J - 5,6 Hz, 1H), 8,32 (t, J - 5,2 Hz, 1H), 7,05 (d, J = 9.2 Hz, 1H), 6.59 - 6,57 (m, 2H), 5,34 (s, 2H), 3.38 - 3.29 (m, 4H); ¹⁹ F NMR (376 MHz, DMSO- de) δ -82,30, -121,85; ESIMS m/z 360.36 ([M + H] ).

5-Amino-2-chSoro-W-(3-(2 _f ,3,3 _f 3-per

(C348)

Isolated as an off-white solid (0,70 g, 21%): mp 118 - 120 °C; *H NMR (400 MHz, DMSO-cs) δ 9.50 (t, J - 5,6 Hz, 1H), 8,27 (t, J - 6,0 Hz, 1H), 7,05 (dd, J - 2.0, 7.6 Hz, 1H), 6.59 - 6.56 (m, 2H), 5.37 (s, 2H), 3,32 - 3.25 (m, 2H), 3.22 - 3.16 (m, 2H), 1.74 - 1,67 (m, 2H); ¹⁹ F NMR (376 MHz, DMSO-c/e) δ -82.37, -121.89; ESIMS m/z 374,33 ([M + H] ⁺ ),

5-Am!no-2-chloro-W-(4-(2 _f 2,3 _? 3 _f 3-pentafSuoropTOpanamsdo)butvi}ben2:a!T!!de

Isolated as a brown gummy solid (0.36 g, 11%): IR 749,81 (C-CI stretching) cm ^{" 3} ; ^' Ή NMR (400 MHz, DMSO-de) δ 9.47 - 9,46 (m, 1H), 8,21 (t, J = 5,2 Hz, 1H), 7,04 (d, J = 8.0 Hz, 1H), 6.58 - 6.55 (m, 2H), 5,33 (s, 2H), 3.29 - 3.15 (m, 4H), 1.57 - 1,44 (m, 4H); ⁱ⁹ F NMR (376 MHz, DMSG-ds) δ -82.35, -121.76; ES!MS m/z 388 ([M + H] ⁺ ). Example 95° Preparation of 2-amino-W-(2,2j2HbriffuGroethyi)aceta ide hydrochloride (C350)

To a stirred solution of te/t-butyl (2-oxo-2-((2,2,2- trifluoroethyl)amino)ethyl)carbamate (C362; 3 g, 15.6 mmol) in dioxane (20 mL) was added 4 M HCi in dioxane (23 mL, 93.8 mmol) dropwise at 0 °C, and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure. The title compound was isolated as an off-white solid (2,4 g), which was used without purification : Ή NMR (300 MHz, DMSO-de) δ 9, 17 - 9.13 (m, 1H), 8.21 (br s, 3H), 4.07 - 3,95 (m, 2H), 3.67 - 3.64 (m, 2H).

The following compounds were prepared in like manner to the procedure outlined in Example 95:

3-Amino-/y-(2,2,2-trifiuoroethy )propanamide hydrochloride (C351)

Isolated as an off-white solid (2.3 g), which was used without purification ; 'H NMR (300 MHz, DMSO-de) δ 8.93 (br s, 1H), 8,21 (br s, 3H), 3.97 - 3.85 (m, 2H), 2,98 - 2.94 (m, 2H), 2,65 - 2.60 (m, 2H),

4-Amino-i¥-(2 _f 2 _f 2-tnf uoroethyi)butanamide hydrochioride (C352)

Isolated as an off-white solid (2 g), The product was used in the next step without purification and analysis.

2-Amino~ ¥~{3,3,3~trifiuoropropyi}acetamide hydrochloride (C353)

Isolated as an off-white solid (2.4 g). The product was used In the next step without purification and analysis,

3-Am!no- f-(3 _? 3 _f 3-tnfiuoropropyl)propanamide hydrochioride (€354)

Isolated as an off-white solid (2.7 g). The product was used In the next step without purification and analysis,

4-Ar!i!no-i¥-(3 _f 3,3-tnf uoropropv!}butanamide hydrochloride (C355)

Isolated as an off-white solid (2,7 g), which was used without purification: ¹ H NMR (300 MHz, DMSO-ce) δ 8,26 (br s, 1H), 8,01 (br s, 3H), 3,31 - 3,24 (m, 2H), 2.7E - 2,72 (m, 2H), 2,51 - 2,36 (m, 2H), 2,18 (t, J = 7.5 Hz, 2H), 1.82 - 1.72 (m, 2H).

acetamic

Isolated as an off-white solid (2,1 g), which was used without purification: *H NMR (300 MHz, DMSO-c/e) δ 9,67 (br s, 1H), 8,24 (br s, 3H), 3,50 - 3,44 (m, 2H), 2.9E - 2,93 (m, 2H).

W-{3-AminopropyS)-2 _i ,2 _? 2-trsfluoroacetam!de hydrochloride (C3S7)

Isoiated as an off-white solid (1.7 g). The product was used In the next step without purification and analysis,

f-(4-AminobutyS}-2 _? 2 _? 2-trsfluoroacetam!de hydrochloride (C3S8)

Isoiated as an off-white solid (3,2 g). The product was used In the next s without purification and analysis.

Isolated as an off-white solid (2,9 g), which was used without purification : *H NMR (300 MHz, DMSG-ds) δ 9 ,78 (br s, 1H), 8.23 (br s, 3H), 3, 56 - 3, 38 (m, 2H), 2, - 2,94 (m, 2H) ,

Isolated as an off-white solid (2.9 g) : The product was used in the next step without purification and analysis,

i¥-(4~Aminobutvl )-2,2 _f 3 _f 3 _f 3"P ^| 8ntaf uoropropanamide hydrochloride (C361 )

Isolated as an off-white solid (3.1 g), which was used without purification NMR (300 MHz, DMSO-de) δ 9.65 (br s, 1H), 8.10 (br s, 3H), 3.23- 3.21 (m, 2H) 2, 76 (m, 2H), 1 , 55 - 1.54 (m, 4H) ,

E ample 96; Preparation of tert-buiyl (2~oxo-2-{(2,2 _f 2~

trif!u©roethyl )amina)ethyf }carbamate (C362)

To a solution of (tert-butoxycarbonyl)glycine (3 g, 17. 1 mmoi) in ethyl acetate (25 mL) were added sequentially 2,2,2-tnfluoroethan- l-amine (2.55 g, 18, 8 mmoi), 2,4,6-tri propyl- l,3,5,2,4,6-trioxatriphosphi nane 2,4,6-trioxide (50% sol ution I n ethyl acetate; 22 mL, 68.5 mmoi), and pyridine (4.4 mL, 54,8 mmoi) . The reaction mixture was stirred at room temperature for 16 hours, then poured i nto water and extracted with ethyl acetate (2 x 50 mL) . The organic layer was dried over anhydrous Na2S0 , filtered and concentrated under reduced pressure to afford the title compound as an off-white sol id (3 g), which was used in the next step without purification and analysis,

The following compounds were prepared in like manner to the procedure outlined in Example 96:

fert-Butyi (3-oxo-3-(C2 _? 2 _? 2-trsfluor iethyS }amsno)propvi}carba!T!ate (C363)

Isolated as an off-white solid (2,9 g) . The product was used In the next step without purification and analysis. ferf-Butyf (4~03 o~4~({2 _f 2 _f 2-trsfluoro8thyS }amsno}butyf )ca

O F

H ₃ C

H

Isolated as an off-white solid (2.9 g) . The product was used In the next step without purification : *H NMR (300 MHz, DMSO-de) δ 8.49 - 8,45 (m, 1H), 6.83 - 6.7? (m, 1H), 3.93 - 3.81 (m, 2H), 2.89 (dd, J - 6.0, 13.2 Hz, 2H), 2. 16 - 2.11 (m, 2H), 1.64 - 1 , 54 (m, 2H), 1.37 (s, 9H) .

tert-Butyl (2~oxo-2~({3,3 _f 3~trifSuoropropyl)amino)ethyf )carbamate (C365)

Isolated as an off-white solid (2,8 g) . The product was used in the next ste without purification : ^X H NMR (300 MHz, DMSOcfe) δ 8.00 - 7.98 (m, 1H), 7.00 - 6 (m, 1H), 3.50 - 3.25 (m, 4H), 2.50 - 2.34 (m, 2H), 1.38 (s, 9H) ,

ferf-Butyf {3-OMO-3-((3 _f 3,3-ts"sf!uoropropv!}amino}propyf }carbamate (C36

Isolated as an off-white solid (3.2 g) . The product was used In the next step without purification : ^X H NMR (300 MHz, DMSO-de) δ 8. 11 - 8,07 (m, 1H), 6, 78 - 6.74 (m, 1H), 3.29 - 3,22 (m, 2H), 3.14 - 3,08 (m, 2H), 2.51 - 2, 19 (rrs, 4H), 1.37 (s, 9H) , fert-Butyl (4-oxo-4-({3 _i 3 _? 3-trsfluoropropv'!)am!no)butyS}carbamate (C367)

Isolated as an off-white solid (3,8 g, crude) . The product was used in the next step without purification : ^X H NMR (300 MHz, DMSO-de) δ 8,05 - 8.01 (m, 1H), 6, 83 - 6.79 (m, 1H), 3,29 - 3.22 (m, 2H), 2,91 - 2.85 (m, 2H), 2.45 - 2,33 (m, 2H), 2.06 - 1.99 (m, 2H), 1.62 - 1.52 (m, 2H), 1.37 (s, 9H) .

Example 97: Preparation of tert-butyf (2-(2,2,2- trifluoroacetaniido)ethyf )carbamate (C368) To a solution of t erf- butyl (2~aminoethyi)carbamate (3 g _f 18.8 mmol) in tetrahydrofuran (25 mL) was added ethyl trifi uoroacetate (2.7 g, 18 ,8 mmol), and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure. The title compound was isolated as an off- white solid (2.8 g), which was used in the next step without any purification : ESIMS m/z 257.40 (! 1 + H] ⁺ ) .

The foiioiving compounds ivere prepared in like manner to the procedure outiined in Example 97:

tert-Butyl (3~(2,2 _f 2~tnfluoroacetamido)propvl)carbamat8 (C369)

Isolated as an off-white solid (3.0 g) . The product was used in the next step without purification : ESIMS m/z 271.40 ([Μ + Η] ^"1" ) .

uoroacetamido)butvl)carbamat8 (C370)

Isolated as an off-white solid (2.8 g) . The product was used In the next step without purification : ESIMS m/z 285.41 ([M + H] ⁺ ) .

ferf-Butyf {2~{2,2,3,3,3-pentafluoropropanamido)ethy!)carbamate (C371)

Isolated as an off-white solid (3.8 g) . The product was used in the next ste without purification : ESIMS m/z 307.37 ([M + H] ⁺ ) .

ferf-Butyf (3-{2 _f 2,3,3, 3~pentaf!uoropropanamido)prop¾f! )carbamate (C37.

Isolated as an off-white solid (4,3 g) . The product was used in the next ste without purification and analysis.

ferf-Buty {4-(2,2,3,3,3-pentafSuoropropanamido)butvl )carbamate (C373j

Isolated as an off-white solid (2.7 g) . The product was used In the next step without purification and analysis.

Example 98: Preparation of S~am!no~2~chSoro-3~fluoroben.ioic acid (C 196)

To a solution of 2-chloro-3-fluoro-5-nitrobenzoic acid (C206; 0,25 g, 1. 14 mmol) in ethyl acetate (20 mL) was added 10% pailadium on carbon (0,07 g), and the reaction mixture was stirred under a hydrogen atmosphere (20 pounds per square i nch (psi)) for 16 hours. The reaction mixture was filtered through a pad of Celite ^® and washed with ethyl acetate, and the fi ltrate was concentrated under reduced pressure. The unpurified product was triturated with r?~pentane. The title compound was isolated as an off-white sol id (0, 18 g, 82%) : ^V N MR (300 MHz, DMSO-de) δ 13 ,24 (br s, 1H), 6.82 - 6, 81 (m, 1H), 6.61 (dd, J = 2.7, 12.0 Hz, 1H), 5.80 (br s, 2H); ESIMS m/z 189.95 ( [M + H] ⁺ ) . Example 99: Preparation of M-allyl-N-(3-amino-2,6-difluorophenyl)-2,2- diff uoroacetamide (C375)

Anhydrous tin chloride (0.62 g, 3.25 mmol) was added portionwise to a stirred sol ution of /V-al lyl-/V-(2,6-difluoro-3-nitrophenyl)-2,2-difluoroacetamide (C247; 0.19 g, 0.65 mmol), in 1 : 1 methanol-dichloromethane ( 10 mL) at 5 °C. The resulting yellow sol ution was stirred at 0-5 °C for 2 hours and for 13 hours at 24 °C. The reaction mixture was concentrated under vacuum on a rotary evaporator. Purification by silica gel flash chromatography using 0-60% ethyl acetate in hexanes as eluent afforded the title compound as a gold oil (0.15 g, 83%) : *H MR (300 MHz, CDCis) δ 6,96 - 6.82 (m, 2H), 6.06 - 5,62 (m, 2H), 5.23 - 5,07 (m, 2H), 4.33 (h, J = 7.6, 7.0 Hz, 2H), 3.61 (s, 2H) ; ESIMS m/z 263 ([M+ H] ⁺ ) .

The following compounds were prepared in like manner to the procedure outlined in Example 99: ferf-Butyf (3~amino~2 _f 6~dif uorophenyS)(prop~2~yn~l~yf )carbamate (C376)

Isolated as a tan solid (0.151 g, 42%) : ^J H NMR (400 Hz, CDC ) δ 6.86 - 6.5S (m, 2H), 4.47 - 4.26 (m, 2H), 3.62 (s, 2H), 2. 17 (dt, J - 18.7, 2.5 Hz, 1H), 1.55 (s, 9H); ESIMS m/z 283 ([M+ H] ⁺ ) .

Example 100; Preparation of £ert~buty! (2,6~diffuoro~3~nitrophenyf )carbamat¾

To a solution of ieri-buty!-/V-((teri-butoxy)carbonyi)-/V-(2,6-dif!uoro-3- nitrophenyl)carbamate (C190) (2.60 g, 6.60 mmol) in ethyl acetate (66 mL) was added trif!uoroacetic acid (7,60 g, 66.0 mmol) . The reaction mixture was stirred at room temperature for 5 days. Additional trifluoroacetic acid (6.02 g, 52 ,3 mmoi) was added, and the reaction mixture was stirred for an additional 5 days. The reaction mixture was transferred to a separatory funnel and washed successively with saturated aqueous sodium bicarbonate solution until the pH of the organic Iayer was >3. The organic iayer was then washed with bri ne, passed through a phase separator to dry and concentrated . Purification by column chromatography using 0 to 20% ethyl acetate/hexanes as eiuent afforded the title compound as a light yellow solid ( 1.32 g, 73%) : ¹ NMR (400 MHz, DMSO-cfe) δ 9.28 (s, 1H), 8.15 (ddd, J - 9.5, 8.3, 5.5 Hz, 1 H), 7.43 (td, J - 9.2, 1.9 Hz, 1H), 1.45 (s, 9H) ; ¹⁹ F N MR (376 MHz, DMSO-cfe) δ - 106.41, - 121.41 ; ESIMS m/z 273 ([M-H]-) .

!e 101 : Preparation of 2-chloro-/¥-{ 2,2-diff uoropropy!)-3-f uoro-5- enzar

To a solution of 2~chioro-3-fiuoro-5-nltrobenzoic acid (C206; 0, 5 g, 2.28 mmoi) in ethyi acetate ( 15 mL) were added 2,2-difluoropropan- l-amine (0,3 g, 2, 28 mmoi), 2,4,6-tri propyl- l,3,5,2,4,6-tnoxatriphosphi nane 2,4,6-trioxide [50% sol ution I n ethyi acetate] (2,7 mL, 9,13 mmo!), pyridine (0,92 mL, 11,41 mmo!). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was diluted with water and extracted with ethyl acetate (2 x 20 mL). The organic layer was dried over anhydrous NazSC , filtered and concentrated under reduced pressure. Purification by column chromatography (silica gel 100 - 200 mesh) eluting with 15 - 20% ethyl acetate in petroleum ether afforded the title compound as an off-white solid (0.35 g, 60%): *H NMR (300 MHz, CDC ) δ 8,35 - 8.33 (m, 1H), 8.13 (dd, J - 2,7, 7.8 Hz, 1H), 6.44 - 6.41 (m, 1H), 3.97 - 3,85 (m, 2H), 1.74 (t, J = 18,6 Hz, 3H); ES!MS m/z 294,91 ([M÷H] ⁺ ).

The following compounds were prepared in like manner to the procedure outlined in Example 101 :

2-ChSoro- f-(2 _f 2-d!fiuorobutyl)-3-fSuoro-S-n!trobenzamsde (C379)

Isolated as an off-white solid (0,4 g, 56%); ^'! H NMR (300 MHz, CDCb) δ 8,35 - 8.33 (m, 1H), 8.12 (dd, J = 2,4, 8.1 Hz, 1H), 6.48 - 6.42 (m, 1H), 3,97 - 3,85 (m, 2H), 2.07 - 1.91 (m, 2H) _; 1.12 (t, J = 7.8 Hz, 3H); ESIMS m/z 310.94 ([M + H] ⁺ ).

Ethyf 3-{2-chSoro-3-f!uoro-5-nitroben2:am!do)-2 _i ,2-dif!uoropropanoate (€380)

Isolated as a brown liquid (0.7 g). The product was used in the next step without purification: ESIMS m/z 355,15 ([M + H] ),

2-Ch!oro-J¥-(2 _f 2-difiuoro- -phenv!ethyt)-3-fSuoro-5-nitrobenxamsde (C381)

Isolated as an off-white solid (0.4 g, 56%): ^l NMR (300 Hz, CDCb) δ 8.26 - 8.23 (m, 1H), 8,10 (dd, J = 2.4, 7,8 Hz, 1H), 7,62 - 7.48 (m, 5H), 6.48 - 6.41 (m, 1H), 4.23 - 4,11 (m, 2H); ESIMS m/z 359.15 ([M + H] ⁺ ).

2~Chloro~3~ffuoro-5~nitro~i¥-(2~oxopropvl}benzaniide (C382)

Isolated as an off-white solid (0.21 g, 32%): *H NMR (400 MHz, CDCI ₃ ) δ 8.37 - 8.34 (m, IH), 8,11 (dd, J = 2.4, 8,4 Hz, IH), 7,05 - 7.01 (m, IH), 4.40 (d, _7 = 4,4 Hz, 2H), 2.31 (s, 3H); ESIMS m/z 274,94 ([M + H] ⁺ ).

2~Chloro~3~ffuoro-5-nitro~i¥-(2~oxobutyS)ben.iam!de iC3S3)

Isolated as a brown liquid (0.35 g). The product was used in the next step without purification: ESIMS m/z 289.15 ([M + Hj ^÷ ).

2~Chloro~3~ffuoro~ ~(4~methvf~2~oxopentyl)~5~nitrobenzamide (C3S4)

Isolated as an off-white solid (0.4 g, 58%): *H NMR (300 MHz, CDCb) δ 8.39 - 8.36 (m, IH), 8.12 (dd, J - 2.4, 7.8 Hz, IH), 7.09 - 7.06 (m, IH), 4.35 (d, J = 4.2 Hz, 2H), 2.42 (d, J = 6.9 Hz, 2H), 2.27 - 2.18 (m, IH), 0.98 (d, J = 6.6 Hz, 6H); ESIMS m/z 317,05 ([M + H] ).

2-ChSoro-3~fluoro~S~nitro-i¥~(2-03o~2~phenyf ethyl )benzamide (C385)

Isolated as an off-white solid (0.4 g, 56%): H NMR (300 MHz, CDCb) δ 8.43 - 8.43 (m, IH), 8.13 (dd, J = 2,4, 7.8 Hz, IH), 8.03 (d, J = 7.2 Hz, 2H), 7,71 - 7.65 (rrs, IH), 7.58 - 7,53 (m, 2H), 7.44 -7,41 (m, IH), 5.01 (d, J = 4,2 Hz, 2H); ESIMS m/z 337,17 ([M + H] ⁺ ),

Example 102: Preparation of 2~chforo~/^~(2 _? 2-dlf!uoroprop¾fl)-5-nltroben.iam!de (C386):

To a solution of 2-chioro-5-nitrobenzoic acid (0.7 g, 3.5 mmol) in

dichloromethane ( 10 mL) were added sequentiaily l-[bis(dlmethylamlno)methy!ene]- lH- l,2,3-triazolo[4,5-b]pyndinium 3-oxid hexafluorophosphate (HATU; 4, 0 g, 10,4 mmol), diisopropylethylamine (3 mL, 17,36 mmol) and 2,2-difiuoropropan- l-amine (0, 5 g, 3.8 mmol). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was poured I nto water and was extracted with dichloromethane (2 x 20 mL) , The organic layer was washed with brine, dried over NazSCk and concentrated under- reduced pressure. Purification by column chromatography (silica gel 100-200 mesh) eiuting with 40 - 50% ethyl acetate i n petroleum ether afforded the title compound as an off-white solid (0,9 g, 93%) : *H NMR (400 MHz, CDC ) δ 8, 53 (d, J = 2.4 Hz, 1H), 8.24 (dd, J = 2.4, 8, 8 Hz, 1H), 7.63 (d, J = 8.8 Hz, 1 H), 6.46 - 6.41 (m, 1H), 3,94 - 3.86 (m, 2H), 1 ,73 (t, J = 18.8 Hz, 3H) ; ESIMS m/z 279.12 ([M + H] ⁺ ).

The following compounds were prepared In like manner to the procedure outlined in Example 102:

2-Ch!oro-J¥-(2 _f 2-difiuorobutyS)-5-nitrobenzamide (C387)

Isolated as an off-white solid (0.4 g, 54%) : *H NMR (300 M Hz, CDC! ?,) δ 8.53 (d, J = 3,0 Hz, 1H), 8,24 (dd, J = 3.3, 8,7 Hz, 1H), 7 ,62 (d, J = 8.7 Hz, 1H), 6.47-6.44 (m, 1H), 3,97 - 3.72 (m, 2H), 2.05 - 1.91 (m, 2H), 1.11 (t, J = 7.5 Hz, 3H) .

EthyH 3-(2-chSoro-5-nitroben2:amsd 3}-2,2-dif!uoropropanoate (C388)

Isolated as an off-white solid (0.7 g, 85%) : H NMR (300 M Hz, CDCb) δ 8.52 (d, J - 2.4 Hz, 1H), 8.25 (dd, J = 2.7, 8,7 Hz, 1H), 7 ,63 (d, J - 9.2 Hz, 1H), 6.54 - 6.52 (m, 1H), 4,38 (q, J = 6,9 Hz, 2H), 4,22 - 4, 11 (m, 2H), 1 ,39 (t, J = 7,2 Hz, 3H) ; ESIMS m/z 336.98 ([Μ + ΗΓ).

2-Ch!oro-J¥-(2 _f 2-d!fiuoro-2-pheny!ethyt)-5-nitrobenzamide (C389)

Isolated as an off-white solid (0.68 g, 80%): ^J H NMR (300 MHz, CDG3) δ 8.42 (d, J = 1.2 Hz, 1H), 8.22 (dd, J = 1.5, 9.3 Hz, 1H), 7.61 - 7,47 (m, 6H), 6,54 - 6.51 (rrs, 1H), 4.32 - 4,10 (m, 2H); ESIMS m/z 341.14 ([M + H] ⁺ ).

2~ChSoro-5-nitro~Af-{2~oxopropy!)benzamide (C390)

Isolated as a yellow solid (0,6 g, 50%): ^l NMR (300 MHz, CDC ) δ 8,53 (d, J 2.4 Hz, 1H), 8.22 (dd, J = 2,1, 8.4 Hz, 1H), 7.61 (d, J = 9,2 Hz, 1H), 7,09 - 7.06 (rrs, 1H), 4.39 (d, J = 4.5 Hz, 2H), 2.28 (s, 3H); ESIMS m/z 257,01 ([M÷H] ⁺ ),

2~Chloro-5~nitro~Af~{2~oxobutyl)ben_iam!de (C391)

Isolated as an off-white solid (0.6 g, 38%): ESIMS m/z 271.01 ([M

methyl-2-OKopentyl}-.

Isolated as a yellow solid (1.2 g, 81%): ^l NMR (400 MHz, DMSG-de) δ 7.06 (d = 8,4 Hz, 1H), 6,66 (d, J = 2.4 Hz, 1H), 6.50 (dd, J = 2,8, 8.4 Hz, 1H), 3.97 (d, J= 6, Hz, 2H), 2.36 (d, J = 6,8 Hz, 2H) 2,09 - 2.00 (m, 1H), 0,88 (d, J = 6,9 Hz, 6H).

2-Chloro-S-nitro-/¥-{2-OMO-2-phenylethyl}benzamide (C393)

Isolated as an off-white solid (0.6 g, 50%): ESIMS m/z 319.21 ([M÷H] ^~ ),

Example 103; Preparatwe-SFC separation of 5~((JS _f 3S)~2,2-dichforo~3~(3 _f 5- dichloropheny)cyclopropane-l-carboxamido)-2-f!uoro-W-(4- fuoropheny benzamsde (F1373) and 5-C(Ji?,3i?)-2,2-dichloro-3-(3 _f 5- dichforopheny!)cycfopropane~l~carboxamido)~2-fluoro~i¥-(4~ fluoropheny benzamide (F1374)

Racemic 5-((irafJs)-2,2-dic loro-3-(3,5-dichlorop enyl)cyclopropane- l- carboxamido)-2-fl uoro-/V-(4-fluorophenyl)benzamide (U. S. Patent Application Publication US20160304522A1 (F129)) was separated by preparative-SFC utilizing the followi ng conditions; IC column (20 mm x 250 mm), 5 Mm; 35/65 MeOH (0.2%

diethylamine)/C02, 40 g/min to give 5-((IS _f 3S)-2,2-dichioro-3-(3,5~

dichlorophenyi)cyclopropane- l-carboxamido)-2-fluoro-A -(4-fluorophenyi)benzamide (F 1373) (2 ^nd el uting enantiomer, 100% ee) and 5-((lR _/ 3R)-2,2-dlchloro-3-(3 _f 5- dichlorophenyi)cyclopropane- l-carboxamldo)-2-fiuoro-A/-(4-fluorophenyl)benzamide (F 1374) ( 1 ^st eluting enantiomer, 98.5% ee).

Example 104; Preparatsve-HPLC separation of 5-({l^,3^)~2,2-dichloro~3~(3 _i S~ dichlorophenyS)cyclopropane-l~carboxarnido}~Af~{2 _f 4~difluorophenyf )~2~ ffuorobenzamide (F1375) and 5~{(lS,3S)~2 _f 2~dichSoro-3-(3 _f 5~

dichlorophenyS)cyclopropane~l-carbo amido}~/¥~(2 _f 4~difluorophenyf )~2~ Huorobenzamide (F 1376)

Racemic 5-((trans)-2,2-dic loro-3-(3,5-dichlorop enyl)cyclopropane-l- carboxamido)-/V-(2,4-difluorophenyl)-2-fluorobenzamide (U.S. Patent Application Publication US20160304522A1 (F61)) was separated by preparative HPLC utilizing the following conditions: OJ - H column (20 mm x 250 mm), 5 μηη; 50/50 isopropanol (0,2% diethylamine)/hexane, 4.0 mL/ min to give 5-((i ?,3?)-2,2-dichloro-3-(3,5- dichloropheny!)cyclopropane-l-carboxamido)~A-(2,4-difluoroph enyl)-2-fluorobenzamlde (F1375) (1 ^st eluting enantiomer, 96.2% ee) and 5-((IS,JS)-2,2-dichloro-3-(3,5- dichlorophenyi)cyclopropane-l-carboxamido)-A-(2,4-difluoroph enyl)-2-fluorobenzaiTilde (F1376) (2 ^nd eluting enantiomer, 96.0% ee).

Example 105; Freparatsve-SFC separation of 2-chloro-S-({I^3^)-2 _f 2-dschSoro- 3~(3 _? 5-dichforopheny!)cycfopropane~l~carboxamsdo)-i¥~(2 _f 4 _f 6~

trif!uorophenyf)beniarnide (F1377) and 2-ch!oro~S~({JS,3S)~2 _f 2~dichSoro-3~ (3 _f 5~dichSorophenvl}cycSopropane-l~carboxamido)~ ~(2 _f 4 _f 6~

trifluorophenyf)benzamide (F1378)

Racemic 2-Chloro-5-((tra/7s^-2,2-dichloro-3-(3,5-dic lorophenyl)cyclopropane-l- carboxamido)-/V-(2,4,6-trifluorophenyl)benzamide (U.S. Patent Application Publication US20160304522A1 (F24)) was separated by preparative-SFC utilizing the following conditions: IC column (20 mm x 250 mm), 5 pm; 35/65 MeOH (0.2%

diethylamlne)/COz _f 40 g/min to give 2-ch!oro-5-((lR _f 3?)-2 _f 2-dichioro-3-(3 _i 5- dichlorophenyl)c^clopropane-l-carboxamido)-/V-(2,4,6-trifluo rophenyl)benzarnide

(F1377) (i ^st eluting enantiomer, 100% ee) and 2-chloro-5-((lS,3S)-2,2-dichloro-3- (3,5-dic lorophenyl)cyclopropane-l-carboxamido)-/V-(2,4,6-trifluorop enyl)benzamide (F1378) (2 ^nd eluting enantiomer, 100% ee).

It Is recognized that some reagents and reaction conditions may not be compatible with certain functionalities that may be present in certain molecules of Formula One or certain molecules used in the preparation of certain molecules of Formula One. In such cases, it may be necessary to employ standard protection and deprotection protocols comprehensively reported in the literature and well known to a person skilled in the art. In addition, in some cases It may be necessary to perform further routine synthetic steps not described herein to compiete the synthesis of desired molecules. A person skilled in the art will also recognize that it may be possible to achieve the synthesis of desired molecules by performing some of the steps of the synthetic routes in a different order to that described, A person skilled in the art will also recognize that it may be possible to perform standard functional group interconversions or substitution reactions on desired molecules to Introduce or modify substituents. Biological Assays

The following bioassays against Beet Armyworm (Spodoptera exigua), Cabbage Looper {Trichoplusia ni), and Yellow Fever Mosquito (/Aedes aegypti), are included herein due to the damage they inflict. Furthermore, the Beet Armyworm and Cabbage Looper are two good indicator species for a broad range of chewing pests. Additionally, the Green Peach Aphid is a good i ndicator species for a broad range of sap-feeding pests. The results with these four Indicator species along with the Yellow Fever Mosquito show the broad useful ness of the molecules of Formula One in controlling pests in Phyla Arthropoda, Mol !usca, and Nematoda (Drewes et al .)

Example A: Bioassays on Beet Armyworm (Spodoptera exigua, LAPHEG)

("BAW") and Cabbage Looper {Trichoplusia n! _l T IPNI) ("CL")

Beet armyworm is a serious pest of economic concern for alfalfa, asparagus, beets, citrus, corn, cotton, onions, peas, peppers, potatoes, soybeans, sugar beets, sunflowers, tobacco, and tomatoes, among other crops. It Is native to Southeast Asia but is now found in Africa, Australia, Japan, North America, and Southern Europe, The larvae may feed in large swarms causing devastating crop losses. It is known to be resistant to several pesticides.

Cabbage looper Is a serious pest found throughout the world. It attacks alfalfa, beans, beets, broccoli, Brussel sprouts, cabbage, cantaloupe, cauliflower, celery, co! iards, cotton, cucumbers, eggplant, kale, lettuce, melons, mustard, parsley, peas, peppers, potatoes, soybeans, spinach, squash, tomatoes, turnips, and watermelons, among other crops. This species is very destructive to plants due to its voracious appetite. The larvae consume three times their weight in food daily. The feeding sites are marked by large accumulations of sticky, wet, fecal material, which may contri bute to higher disease pressure thereby causing secondary problems on the plants In the site.

It is known to be resistant to several pesticides.

Consequently, because of the above factors control of these pests is i mportant.

Furthermore, molecules that control these pests (BAW and CL), which are known as chewing pests, will be useful in controlling other pests that chew on plants.

Certai n molecules disclosed In this document were tested against BAW and CL using procedures described i n the fol lowing examples. In the reporting of the results, the

"BAW & CL Rating Table" was used (See Table Section),

Bioassays on BAW

Bioassays on BAW were conducted usi ng a 128-we!l diet tray assay. One to five second Instar BAW larvae were placed In each well (3 mL) of the diet tray that had been previously filled with 1 mL of artificial diet to which 50 μς/αη ² of the test molecule (dissolved in 50 uL of 90 : 10 acetone-water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a clear self-adhesive cover, vented to allow gas exchange, and held at 25 °C, 14: 10 light-dark for five to seven days. Percent mortality was recorded for the larvae in each well ; activity i n the eight wells was then averaged. The results are Indicated In the table entitled "Table ABC: Biological Results" (See Table Section) . Bioassays on CL

Bioassays on CL were conducted using a 128-wei! diet tray assay. One to five second Instar CL larvae were placed in each well (3 mL) of the diet tray that had been previously filled with 1 mL of artificial diet to which 50 pg/cm ² of the test molecule (dissolved in 50 uL of 90 : 10 acetone-water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a clear self-adhesive cover, vented to allow gas exchange, and held at 25 °C, 14: 10 light-dark for five to seven days. Percent mortality was recorded for the larvae in each well ; activity i n the eight wells was then averaged. The results are indicated in the table entitled "Table ABC: Biological Results" (See Table Section) .

Example B: Bioassays on Green Peach Aphid (Myzus persicae, !^YZUPE)

("CPA"),

GPA is the most significant aphid pest of peach trees, causing decreased growth, shriveli ng of the leaves, and the death of various tissues. It is also hazardous because It acts as a vector for the transport of plant vi ruses, such as potato vi rus Y and potato leafroii virus to members of the nightshade/potato family Solanaceae, and various mosaic viruses to many other food crops. GPA attacks such plants as broccoli, burdock, cabbage, carrot, cauliflower, dai kon, eggplant, green beans, lettuce, macadamia, papaya, peppers, sweet potatoes, tomatoes, watercress, and zucchini, among other crops. GPA also attacks many ornamental crops such as carnation, chrysanthemum, flowering white cabbage, polnsettia, and roses. GPA has developed resistance to many pesticides. Currently, it is a pest that has the third largest number of reported cases of insect resistance (Sparks et al .) - Consequently, because of the above factors control of this pest is important. Furthermore, molecules that control this pest (GPA), which is known as a sap-feeding pest, are useful i n controlling other pests that feed on the sap from plants.

Certai n molecules disclosed in this document were tested against GPA using procedures described i n the following example. In the reporting of the results, the "GPA & YFM Rating Table" was used (See Table Section) .

Cabbage seedli ngs grown in 3-inch pots, with 2-3 small (3-5 cm) true leaves, were used as test substrate, The seedl ings were Infested with 20-50 GPA (wingless adult and nymph stages) one day prior to chemical application. Four pots with individual seedlings were used for each treatment. Test molecules (2 mg) were dissolved in 2 mL of acetone/methanol ( 1 : 1) solvent, formi ng stock solutions of 1000 ppm test molecule. The stock sol utions were diluted 5X with 0.025% Tween 20 In water to obtai n the sol ution at 200 ppm test molecule. A hand- held aspirator-type sprayer was used for sprayi ng a sol ution to both sides of cabbage leaves until runoff. Reference plants (solvent check) were sprayed with the diluent only containing 20% by volume of acetone/methanol ( 1 : 1) solvent. Treated plants were held in a holding room for three days at approximately 25 °C and ambient relative humidity (RH) prior to grading.

Evaluation was conducted by counti ng the number of live aphids per plant under a microscope. Percent control was measured using Abbott's correction formula (W. S. Abbott, "A Method of Computing the Effectiveness of an Insecticide" J . Econ. Entomo! , 18 (1925), pp.265 -267) as follows. Corrected % Control = 100 * (X - Y) / X where X = No, of l ive aphids on solvent check plants and Y = No. of live aphids on treated plants. The results are Indicated In the table entitled "Table ABC : Biological Results" (See Table Section) ,

Example C: Bsoassays on Yellow Fever Mosquito (Aedes aegypti, AEDSAE) C"YFM").

YFM prefers to feed on humans duri ng the dayti me and is most frequently found in or near human habitations. YFM Is a vector for transmitti ng several diseases. It Is a mosquito that can spread the dengue fever and yellow fever viruses. Yeiiow fever Is the second most dangerous mosquito-borne disease after malaria. Yellow fever is an acute viral hemorrhagic disease and up to 50% of severely affected persons without treatment will die from yellow fever. There are an estimated 200,000 cases of yellow fever, causing 30,000 deaths worldwide each year. Dengue fever is a nasty, vi ral disease; it is someti mes cal led "breakbone fever" or "break-heart fever" because of the intense pain it can produce. Dengue fever ki lls about 20,000 people annually. Consequently, because of the above factors control of this pest is important. Furthermore, molecules that control this pest (YFM), which is known as a sucking pest, are useful in controlling other pests that cause human and animal sufferi ng,

Certai n molecules disclosed In this document were tested against YFM using procedures described i n the following paragraph. In the reporting of the results, the "GPA & YFM Rating Table" was used (See Table Section) ,

Master plates contai ning 400 pg of a molecule dissolved in 100 μ!_ of dimethyl sulfoxide (DMSO) (equivalent to a 4000 pprrs solution) are used. A master plate of assembled molecules contains 15 μΙ_ per well . To this plate, 135 μΙ_ of a 90 : 10

water/acetone mixture is added to each well . A robot (Biomek® ΜΧΡ Laboratory

Automation Workstation) is programmed to dispense 15 μΙ_ aspirations from the master plate into an empty 96-weli shallow plate ("daughter" plate) . There are 6 reps

("daughter" plates) created per master. The created "daughter" plates are then immediately infested with YFM larvae.

The day before plates are to be treated, mosquito eggs are placed in Millipore water contai ning liver powder to begin hatching (4 g Into 400 rrsL) . After the "daughter" plates are created using the robot, they are infested with 220 μί. of the liver

powder/larval mosquito mixture (about 1 day-old larvae) . After plates are infested with mosquito larvae, a non-evaporative l id is used to cover the plate to reduce drying. Plates are held at room temperature for 3 days prior to grading, After 3 days, each well Is observed and scored based on mortal ity. The results are i ndicated in the table entitled "Table ABC; Biological! Results" (See Table Section) ,

Agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, polymorphs, isotopes, and radionuclides

Molecules of Formula One may be formulated into agriculturally acceptable acid addition salts, By way of a non-li miting example, an amine function can form salts with hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, benzoic, citric, malonic, salicylic, malic, fumaric, oxalic, succinic, tartaric, lactic, gluconic, ascorbic, ma!eic, aspartic, benzenesuifonic, methanesulfonic, ethanesuifon!c, hydroxyl-methanesulfonic, and hydroxyethanesulfonic acids. Additionally, by way of a non-li miting example, an acid function can form salts including those derived from alkali or alkali ne earth metals and those derived from ammonia and amines. Examples of preferred cations include sodium, potassium, and magnesi um.

Molecules of Formula One may be formulated into salt derivatives. By way of a non-limiting example, a salt derivative may be prepared by contacting a free base with a sufficient amount of the desired acid to produce a salt, A free base may be regenerated by treating the salt with a suitable dilute aqueous base solution such as dilute aqueous sodium hydroxide, potassium carbonate, ammonia, and sodium bicarbonate. As an example, in many cases, a pesticide, such as 2,4-D, is made more water-soluble by converting it to its dimethylamine salt,

Molecules of Formula One may be formulated into stable complexes with a solvent, such that the complex remains intact after the non-complexed solvent is removed. These complexes are often referred to as "solvates, " However, it is particularly desi rable to form stable hydrates with water as the solvent.

Molecules of Formula One containi ng an acid functionality may be made into ester derivatives. These ester derivatives can then be applied in the same manner as the molecules disclosed in this document are applied.

Molecules of Formula One may be made as various crystal polymorphs.

Polymorphism is important in the development of agrochemicals since different crystal polymorphs or structures of the same molecule can have vastly different physical properties and biological performances.

Molecules of Formula One may be made with different isotopes. Of particular importance are molecules havi ng ² H (also known as deuterium) or ³ H (also known as tritium) in place of Molecules of Formula One may be made with different

radionuclides. Of particular i mportance are molecules havi ng ¹⁴ C (also known as radiocarbon) . Molecules of Formula One having deuteri um, tritium, or ¹⁴ C may be used in biological studies allowing tracing in chemical and physiological processes and half-life studies, as well as, MoA studies.

Combinations

In another embodiment of this Invention, molecules of Formula One may be used in combination (such as, in a compositional mixture, or a simultaneous or sequential application) with one or more active ingredients.

In another embodiment of this Invention, molecules of Formula One may be used in combination (such as, in a compositional mixture, or a simultaneous or sequential application) with one or more active ingredients each having a MoA that is the same as, similar to, but more likely - different from, the MoA of the molecules of Formuia One, In another embodiment, molecules of Formuia One may be used in combination (such as, in a compositional mixture, or a simultaneous or sequential application) with one or more molecules having acarlcida!, aigicidal, avicidal, bactericidal, fungicidal, herbicidal, insecticidal, moliusclcida!, nematicidal, rodenticida!, and/or virucidal properties.

In another embodiment, the molecules of Formuia One may be used in

combination (such as, in a compositional mixture, or a simultaneous or sequential application) with one or more molecules that are antifeedants, bird repellents, chemosteriiants, herbicide safeners, insect attractants, Insect repellents, mammal repellents, mating disrupters, plant activators, plant growth regulators, and/or

synergists.

In another embodiment, molecules of Formula One may also be used in combination (such as in a compositional mixture, or a simultaneous or sequential application) with one or more biopestlcldes.

In another embodiment, in a pesticidai composition combinations of a molecule of

Formuia One and an active Ingredient may be used in a wide variety of weight ratios. For example, in a two-component mixture, the weight ratio of a molecule of Formula One to an active ingredient, the weight ratios in Table B may be used. However, in general, weight ratios less than about 10:1 to about 1:10 are preferred. It Is also preferred sometimes to use a three, four, five, six, seven, or more, component mixture comprising a molecule of Formuia One and an additional two or more active ingredients.

Weight ratios of a molecule of Formuia One to an active Ingredient may also be depicted as X:Y; wherein X is the parts by weight of a molecule of Formula One and Y is the parts by weight of active ingredient. The numericai range of the parts by weight for X is 0 < X≤ 100 and the parts by weight for Y is 0 < V < 100 and is shown graphically in TABLE C, By way of non-limiting example, the weight ratio of a molecule of Formuia One to an active Ingredient may be 20:1. Ranges of weight ratios of a molecule of Formula One to an active ingredient may be depicted as Xi i Yi to Xz '. Yz, wherei n X and V are defi ned as above.

In one embodiment, the range of weight ratios may be Xi : Yi to Xz '. Yz, wherein Xi > Yi and Xz < Yz, By way of non-limiting example, the range of a weight ratio of a molecule of Formula One to an active ingredient may be between 3 : 1 and 1 : 3, Inclusive of the endpoints.

In another embodiment, the range of weight ratios may be X . Yi to Xz '. Yz, wherei n Xi > Yi and Xz > Yz. By way of non-li miting example, the range of weight ratio of a molecule of Formula One to an active i ngredient may be between 15 : 1 and 3 : 1, incl usive of the endpoints.

In another embodiment, the range of weight ratios may be Xi '. Yi to Xz '. Yz, wherei n Xi < Yi and Xz < Yz. By way of non-li miting example, the range of weight ratios of a molecule of Formula One to an active i ngredient may be between about 1 : 3 and about 1 : 20, Inclusive of the endpoints.

FormuSations

A pesticide is many times not suitable for application In its pure form. It is usually necessary to add other substances so that the pesticide may be used at the required concentration and in an appropriate form, permitting ease of application, handli ng, transportation, storage, and maximum pesticide activity. Thus, pesticides are formulated into, for example, baits, concentrated emulsions, dusts, emulsiflab!e concentrates, fumigants, gels, granules, microencapsulations, seed treatments, suspension concentrates, suspoemu!sions, tablets, water sol uble liquids, water dispersib!e granules or dry fiowables, wettable powders, and uitra-low volume solutions,

Pesticides are applied most often as aqueous suspensions or emulsions prepared from concentrated formulations of such pesticides. Such water-soluble, water- suspendable, or emulsifiabie formulations are either solids, usually known as wettable powders, water dispersibie granules, liquids usually known as emulsifiabie concentrates, or aqueous suspensions. Wettable powders, which may be compacted to form water dispersibie granules, comprise an inti mate mixture of the pesticide, a carrier, and surfactants. The concentration of the pesticide Is usually from about 10% to about 90% by weight. The carrier is usually selected from among the attapuigite clays, the montmoriiionite clays, the diatomaceous earths, or the purified silicates. Effective surfactants, comprising from about 0.5% to about 10% of the wettable powder, are found among sulfonated lignins, condensed naphthaienesulfonates,

naphthaienesulfonates, alkylbenzenesuifonates, a! kyl sulfates, and non-ionic surfactants such as ethylene oxide adducts of aikyi phenols.

Emulsifiabie concentrates of pesticides comprise a convenient concentration of a pesticide, such as from about 50 to about 500 grams per liter of liquid dissolved In a carrier that s either a water miscible solvent or a mixture of water-immiscible organic solvent and emu!sifiers. Usefui organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high-boiling naphthalenic and oiefinlc portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such as 2-ethoxyethanol. Suitable emulsifiers for emulsifiab!e concentrates are selected from conventional anionic and non-Ionic surfacta ts.

Aqueous suspensions comprise suspensions of water-Insoluble pesticides dispersed in an aqueous carrier at a concentration in the range from about 5% to about 50% by weight. Suspensions are prepared by finely grinding the pesticide and vigorously mixing it into a carrier comprised of water and surfactants. Ingredients, such as inorganic salts and synthetic or natural gums may, also be added to increase the density and viscosity of the aqueous carrier. It is often most effective to grind and mix the pesticide at the same time by preparing the aqueous mixture and homogenizing It In an implement such as a sand mill, bail mill, or piston-type homogenizer, The pesticide in suspension might be microencapsulated in plastic polymer.

Oil dispersions (OD) comprise suspensions of organic solvent-insoluble pesticides finely dispersed In a mixture of organic solvent and emulsifiers at a concentration in the range from about 2% to about 50% by weight. One or more pesticide might be dissolved in the organic solvent. Useful organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high-boiling naphthalenic and oiefinlc portions of petroleum such as heavy aromatic naphtha. Other solvents may include vegetable oils, seed oils, and esters of vegetable and seed oils. Suitable emulsifiers for oil dispersions are selected from conventional anionic and non-ionic surfactants. Thickeners or gelling agents are added in the formulation of oil dispersions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets.

Pesticides may also be applied as granular compositions that are particularly useful for applications to the soil. Granular compositions usually contain from about

0.5% to about 10% by weight of the pesticide, dispersed In a carrier that comprises clay or a similar substance. Such compositions are usually prepared by dissolving the pesticide in a suitable solvent and applying it to a granular carrier, which has been pre ^¬ formed to the appropriate particle size, in the range of from about 0.5 mm to about 3 mm. Such compositions may also be formulated by making a dough or paste of the carrier and molecule, and then crushing and drying to obtain the desired granular particle size. Another form of granules is a water emuisifiab!e granule (EG). It Is a formulation consisting of granules to be applied as a conventional oil-ln-water emulsion of the active Ingredient(s), either soiubliized or diluted in an organic solvent, after disintegration and dissolution in water, Water emulslfiabie granules comprise one or several active ingredient(s), either soiubilized or diluted i n a suitable organic solvent that is (are) absorbed in a water sol uble polymeric shell or some other type of soluble or insoluble matrix.

Dusts contai ning a pesticide are prepared by inti mately mixing the pesticide i n powdered form with a suitable dusty agricultural carrier, such as kaol in clay, ground volcanic rock, and the like. Dusts can suitably contai n from about 1% to about 10% of the pesticide. Dusts may be applied as a seed dressi ng or as a foliage application with a dust blower machine.

It Is equally practical to apply a pesticide in the form of a solution in an appropriate organic solvent, usual ly petroleum oil, such as the spray oi ls, which are widely used in agricultural chemistry.

Pesticides can also be applied in the form of an aerosol composition. In such compositions, the pesticide is dissolved or dispersed in a carrier, which is a pressure- generating propellant mixture. The aerosol composition is packaged in a container from which the mixture Is dispensed through an atomizing valve.

Pesticide baits are formed when the pesticide is mixed with food or an attractant or both. When the pests eat the bait, they also consume the pesticide. Baits may take the form of granules, gels, flowabie powders, liquids, or solids. Baits may be used in pest harborages,

Fumlgants are pesticides that have a relatively high vapor pressure and hence can exist as a gas In sufficient concentrations to kill pests in sol i or enclosed spaces. The toxicity of the fumigant is proportional to its concentration and the exposure time. They are characterized by a good capacity for diffusion and act by penetrati ng the pest's respiratory system or being absorbed through the pest's cuticle, Fumlgants are applied to control stored product pests under gas proof sheets, in gas sealed rooms or buildings, or in special chambers.

Pesticides may be microencapsulated by suspending the pesticide particles or droplets in plastic polymers of various types. By altering, the chemistry of the polymer or by changing factors In the processing, microcapsules may be formed of various sizes, sol ubility, wall thicknesses, and degrees of penetrability. These factors govern the speed with which the active ingredient withi n is released, which in turn, affects the residual performance, speed of action, and odor of the product. The microcapsules might be formulated as suspension concentrates or water dispersible granules.

Oil solution concentrates are made by dissolving pesticide i n a solvent that will hold the pesticide In solution, Oil solutions of a pesticide usually provide faster knockdown and kill of pests than other formulations due to the solvents themselves having pesticidal action and the dissolution of the waxy covering of the i ntegument increasing the speed of uptake of the pesticide, Other advantages of oil solutions Include better storage stability, better penetration of crevices, and better adhesion to greasy surfaces,

Another embodiment is an oil-in-water emulsion, wherein the emulsion comprises oily globules which are each provided with a lamellar liquid crystal coati ng and are dispersed in an aqueous phase, wherein each oi ly globule comprises at least one molecule which is agriculturally active, and is Individually coated with a monolamellar or o!lgolamel!ar layer comprising : ( 1) at least one non-ionic lipophilic surface-active agent, (2) at least one non-Ionic hydrophiilc surface-active agent, and (3) at least one ionic surface-active agent, wherein the globules having a mean particle diameter of less than 800 nanometers.

Other formulation components

General ly, when the molecules disclosed in Formula One are used in a

formulation, such formulation can also contain other components. These components incl ude, but are not limited to, (this Is a non-exhaustive and non-mutually exclusive list) wetters, spreaders, stickers, penetrants, buffers, sequestering agents, drift reduction agents, compatibility agents, anti-foam agents, cleaning agents, and emuisifiers, A few components are described forthwith,

A wetting agent is a substance that when added to a l iquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which It Is spreading . Wetti ng agents are used for two mai n functions i n agrochemical formulations ; during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water i n a spray tank to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersib!e granules. Examples of wetting agents used In wettable powder, suspension concentrate, and water-dispersible granule formulations are: sodium lauryl sulfate, sodium dioctyl sulfosucclnate, a!kyi phenol ethoxylates, and aliphatic alcohol ethoxyiates.

A dispersing agent is a substance that adsorbs onto the surface of particles, helps to preserve the state of dispersion of the particles, and prevents them from

reaggregating . Dispersing agents are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles redisperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates, and water-dispersible granules. Surfactants that are used as dispersing agents have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to reaggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettabie powder formulations, the most common dispersing agents are sodi um iignosu!fonates. For suspension

concentrates, very good adsorption and stabilization are obtai ned using polyelectrolytes, such as sodi um-naphthalene-sulfonate-formaldehyde-condensates. Tristyrylphenol ethoxylate phosphate esters are also used. Non-ionics such as a! kylarylethyiene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersing agents for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersing agents. These have very long hydrophobic 'backbones' and a large number of ethylene oxide chains forming the 'teeth' of a 'comb' surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring poi nts onto the particle surfaces.

Examples of dispersing agents used i n agrochemical formulations are: sodium llgnosulfonates, sodi um naphthalene sulfonate formaldehyde condensates,

tristyrylphenol-ethoxylate-phosphate-esters, aliphatic alcohol ethoxyiates, aikyl ethoxyiates, EO-PO block copolymers, and graft copolymers.

An emulsifying agent Is a substance that stabilizes a suspension of droplets of one liquid phase in another liquid phase. Without the emulsifying agent, the two liquids would separate into two immiscible liquid phases. The most commonly used emulsifier blends contain an al kyiphenoi or an aliphatic alcohol with twelve or more ethylene oxide units and the oil-soluble calci um salt of dodecyl benzenesulfonic acid. A range of hydrophi le-llpophiie balance ("HLB") val ues from about 8 to about 18 will normally provide good stable emulsions. Emulsion stability can sometimes be improved by the addition of a smal l amount of an EO-PO block copolymer surfactant.

A soiubilizlng agent is a surfactant that will form micelles in water at

concentrations above the critical micelle concentration. The micel les are then able to dissolve or sol ubillze water-insoluble materials inside the hydrophobic part of the micelle. The types of surfactants usually used for sol ubilization are non - ionics, sorbitan monooleates, sorbitan monooleate ethoxyiates, and methyl oleate esters.

Surfactants are sometimes used, either alone or with other additives such as mineral or vegetable oi ls as adj uvants to spray-tank mixes to improve the biological performance of the pesticide on the target. The types of surfactants used for

bioenhancement depend general ly on the nature and mode of action of the pesticide. However, they are often non-ionics such as : aikyl ethoxyiates, linear aliphatic alcohol ethoxyiates, and aliphatic amine ethoxyiates.

A carrier or dil uent in an agricultural formulation is a material added to the pesticide to give a product of the required strength. Carriers are usually materials with high absorptive capacities, while diluents are usually materials with low absorptive capacities. Carriers and diluents are used in the formulation of dusts, wettable powders, granules, and water-dispersible granules.

Organic solvents are used mainly in the formulation of emuisifiabie concentrates, oil-in-water emulsions, suspoemu!sions, oil dispersions, and ultra-low volume formulations, and to a lesser extent, granular formulations. Sometimes mixtures of solvents are used. The first main groups of solvents are aliphatic paraffinic oils such as kerosene or refined paraffins. The second main group (and the most common) comprises the aromatic solvents such as xylene and higher molecular weight fractions of C9 and CIO aromatic solvents. Chlorinated hydrocarbons are useful as cosoivents to prevent crystallization of pesticides when the formulation is emulsified into water. Alcohols are sometimes used as cosoivents to increase solvent power. Other solvents may include vegetable oils, seed oils, and esters of vegetable and seed oils.

Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, oil dispersions, emulsions and suspoemuisions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fail into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate and oil dispersion formulations using clays and silicas. Examples of these types of materials, include, but are not limited to, montmorillonite, bentonite, magnesium aluminum silicate, and attapulgite. Water- soluble polysaccharides in water based suspension concentrates have been used as thickening-gelling agents for many years, The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds or are synthetic derivatives of cellulose, Examples of these types of materials Include, but are not limited to, guar gum, locust bean gum, carrageenam, alginates, methyl cellulose, sodium carboxymethyi cellulose

(SCMC), and hydroxyethyl cellulose (HEC), Other types of anti-settling agents are based on modified starches, poiyacrylates, polyvinyl alcohol, and polyethylene oxide. Another good anti-settling agent is xanthan gum.

Microorganisms can cause spoilage of formulated products. Therefore, preservation agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt, sorbic acid and its sodium or potassium salts, benzoic acid and Its sodium salt, p-hydroxybenzolc acid sodium salt, methyl p-hydroxybenzoate, and l,2-benzisothiazolin-3-one (BIT).

The presence of surfactants often causes water-based formulations to foam during mixing operations in production and in application through a spray tank. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti- foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiioxane, while the non-si!icone anti-foam agents are water- insoluble oils, such as octanol and nonanoi, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

"Green" agents {e.g. , adj uvants, surfactants, solvents) can reduce the overal l environmental footpri nt of crop protection formulations. Green agents are biodegradable and generally derived from natural and/or sustainable sources, e.g. plant and ani mal sources. Specific examples are: vegetable oi ls, seed oils, and esters thereof, also a!koxy!ated alky! polyglucosldes.

Applications

Molecules of Formula One may be applied to any locus. Particular loci to apply such molecules include loci where alfalfa, almonds, apples, barley, beans, canola, corn, cotton, crucifers, flowers, fodder species (Rye Grass, Sudan Grass, Tall Fescue, Kentucky Bl ue Grass, and Clover), fruits, lettuce, oats, oil seed crops, oranges, peanuts, pears, peppers, potatoes, rice, sorghum, soybeans, strawberries, sugarcane, sugarbeets, sunflowers, tobacco, tomatoes, wheat (for example, Hard Red Winter Wheat, Soft Red Winter Wheat, White Winter Wheat, Hard Red Spring Wheat, and Durum Spring Wheat), and other val uable crops are growing or the seeds thereof are goi ng to be planted.

Molecules of Formula One may also be applied where plants, such as crops, are growing and where there are low levels (even no actual presence) of pests that can commercially damage such plants. Applying such molecules in such locus is to benefit the plants being grown in such locus. Such benefits, may include, but are not limited to : helping the plant grow a better root system; helping the plant better withstand stressful growing conditions; improving the health of a plant; improving the yield of a plant (e.g. increased biomass and/or increased content of valuable Ingredients) ; improving the vigor of a plant {e.g. improved plant growth and/or greener leaves) ; improving the quality of a plant {e.g. improved content or composition of certai n ingredients); and improvi ng the tolerance to abiotic and/or biotic stress of the plant.

Molecules of Formula One may be appl ied with ammonium sulfate when growing various plants as this may provide additional benefits.

Molecules of Formula One may be appl ied on, in, or around plants genetically modified to express specialized traits, such as Bacillus thuringiensis (for example, CrylAb, CrylAc, CrylFa, CrylA.105, Cry2Ab, Vi p3A, mCry3A, Cry3Ab, Cry3Bb,

Cry34Abl/Cry35Abl), other i nsecticidal toxins, or those expressing herbicide tolerance, or those with "stacked" foreign genes expressing i nsecticidal toxins, herbicide tolerance, nutrition-enhancement, or any other beneficial traits.

Molecules of Formula One may be applied to the foliar and/or fruiting portions of plants to control pests. Either such molecules will come i n direct contact with the pest, or the pest will consume such moiecuies when eating the plant or while extracting sap or other nutrients from the plant.

Moiecuies of Formula One may also be applied to the soil, and when applied in this manner, root and stem feeding pests may be controiled . The roots may absorb such molecules thereby taking it up into the foliar portions of the plant to control above ground chewi ng and sap feeding pests.

Systemic movement of pesticides i n plants may be utilized to control pests on one portion of the plant by applying (for example by spraying a locus) a molecule of Formula One to a different portion of the plant. For example, control of foliar-feeding insects may be achieved by drip irrigation or furrow appl ication, by treating the soil with for example pre- or post-planting soil drench, or by treating the seeds of a plant before planti ng ,

Moiecuies of Formula One may be used with baits. Generally, with baits, the baits are placed i n the ground where, for example, termites can come into contact with, and/or be attracted to. the bait, Baits can also be applied to a surface of a buildi ng, (horizontal, vertical, or slant surface) where, for example, ants, termites, cockroaches, and flies, can come into contact with, and/or be attracted to, the bait.

Moiecuies of Formula One may be encapsulated inside, or placed on the surface of a capsule. The size of the capsules can range from nanometer size (about 100-900 nanometers i n diameter) to micrometer size (about 10-900 microns I n diameter) ,

Molecules of Formula One may be appl ied to eggs of pests. Because of the unique ability of the eggs of some pests to resist certai n pesticides, repeated applications of such molecules may be desi rable to control newly emerged larvae.

Molecules of Formula One may be appl ied as seed treatments, Seed treatments may be applied to all types of seeds, Including those from which plants genetically modified to express specialized traits will germinate. Representative examples include those expressing proteins toxic to invertebrate pests, such as Bacillus thuringiensis or other insecticidal toxins, those expressing herbicide tolerance, such as "Roundup Ready" seed, or those with "stacked" foreign genes expressing insecticidal toxins, herbicide tolerance, nutrition-enhancement, drought tolerance, or any other beneficial traits, Furthermore, such seed treatments with molecules of Formula One may further enhance the ability of a plant to withstand stressful growing conditions better, This results in a healthier, more vigorous plant, which can lead to higher yields at harvest time.

Generally, about 1 gram of such molecules to about 500 grams per 100,000 seeds Is expected to provide good benefits, amounts from about 10 grams to about 100 grams per 100,000 seeds is expected to provide better benefits, and amounts from about 25 grams to about 75 grams per 100,000 seeds is expected to provide even better benefits. Molecules of Formula One may be applied with one or more active ingredients i n a soil amendment. Molecules of Formula One may be used for controlling endoparasites and ectoparasites in the veterinary medicine sector or in the field of non-human-animal keeping. Such molecules may be applied by oral administration in the form of, for example, tablets, capsules, drinks, granules, by dermal application in the form of, for example, dipping, spraying, pouring on, spotting on, and dusting, and by parenteral administration in the form of, for example, an injection.

Molecules of Formula One may also be employed advantageously in livestock keeping, for example, cattle, chickens, geese, goats, pigs, sheep, and turkeys. They may also be employed advantageously in pets such as, horses, dogs, and cats. Particular pests to control would be flies, fleas, and ticks that are bothersome to such animals. Suitable formulations are administered orally to the animals with the drinking water or feed. The dosages and formulations that are suitable depend on the species.

Molecules of Formula One may also be used for controlling parasitic worms, especially of the intestine, in the animals listed above,

Molecules of Formula One may also be employed in therapeutic methods for human health care, Such methods include, but are limited to, oral administration in the form of, for example, tablets, capsules, drinks, granules, and by dermal application.

Molecules of Formula One may also be applied to invasive pests. Pests around the world have been migrating to new environments (for such pest) and thereafter becoming a new Invasive species in such new environment. Such molecules may also be used on such new Invasive species to control them In such new environments.

In light of the above and the Table section below, the following details are additionally provided,

1. A molecule having the following formula

wherein:

(A) R ¹ Is selected from the group consisting of H, F, CI, Br, I, CN, NQz, SFs and (Ci-C3)haloalkyi;

(B) R ² is selected from the group consisting of H, F, CI, Br, I, CN, NO2, SFs and (Ci-C3)haloalkyl; (C) R ³ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, SF5, and (Ci~C3)haloaikyi;

(D) R ⁴ is selected from the group consisting of H, F, CI, Br, I, CN, MOz, SF5, and (Ci-C3)haloalkyi;

(E) R ⁵ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, SF5, and (Ci-C3)haloalkyl;

(F) R ⁶ is H;

(G) R ⁷ is selected from the group consisting of F, Ci, and Br;

(H) R ⁸ is selected from the group consisting of F, Ci, and Br;

(I) R ⁹ is H;

(J) Q ¹ is selected from the group consisting of 0 and S;

(&) Q ² Is selected from the group consisting of 0 and S;

(L) R ¹⁰ is selected from the group consisting of H, (C1-C3) aiky!, (C2-

C ₃ )alkenyl, (Cz-Csjalkynyl, (Ci-C ₃ )alkylO(Ci-C ₃ )alkyl, and (Ci-C ₃ )alkylOC(=0)(Ci-

Cjjalkyl;

( ) R ¹¹ is selected from the group consisting of H, F, Ci, Br, I, CN, NO2, (G~ C ₃ )aikyi, (Ci~C ₃ )haloalkyi, and (G-C ₃ )a!koxy;

( ) R ¹² is selected from the group consisting of H, F, Ci, Br, I, CN, NO2, (Ci- C3)aikyi, {Ci-C3)haloalkyi, and (G-C3)aikoxy;

(O) R ¹³ is selected from the group consisting of H, F, Ci, Br, I, CN, NO2, (G- C3)aikyi, (Ci-Csjhaloalkyl, and (G-C3)aikoxy;

(P) R ¹⁴ is selected from the group consisting of H, F, Ci, Br, I, CN, NO?., (G- C3)aikyi, (G-C3)haioalkyi, and (G~C3)aikoxy;

(Q) X ³ is:

(!) N(R ^15a )(R ^15b ) wherein

(a) said R ^15a is selected from the group consisting of H, (G- C3)alkyi, (C2-C3)alkenyl, (C2-C3)alkynyi, (G-C3)haloalkyl, (G- C ₃ )alkyiphenyl, (Ci-G alkylOiG-G alkyl, (G-C3)alkylOC(=0)(Ci- C ₃ )alkyi, and C(=0)(Ci-C ₃ )alkyl, and

(b) said R ^15b Is a substituted or unsubstituted phenyl, said substituted phenyl has one or more substituents selected from the group consisting of H, F, Ci, Br, I, CN, NO2, NH2, OH, SFs, (G- C3)aikyi, (Ci-C3)haloalkyl, (C2-C3)alkenyl, (C2-C3)haloalkenyi, (G- C3)aikoxy, (C=0)0(G-C ₃ )alkyl, 0(C=0)(G-C3)alkyl, N(R ^15c ) ₂ ,

N = CHN(R ^15c )(X ⁴ ), N(R ^15c )C(-0)0(X ⁴ ), N(R ^15c )S( -OMX ),

( R ^15c )C ( -Q) { R ^15c )X ⁴ , N(R ^15c )C( ^~ S) ( R ^15c ) 2,

N(R ^15c )C(=S)N(R ^15c )X ⁴ , N(R ^15c )(Ci-C ₃ )alkylX ⁴ , N(R ^15c )(CH(0(G- C ₃ )a! kyi) ₂ ), N(R ^15c )i(Ci-C3)a!kyiOC(=0)(Ci-C ₃ )a!kyi), N(R ^15c )((Ci- C ₃ )a! kyiC(=G)N(R ^15c ) ₂ ), N(R ^15c )C[ = G)(R ^l5c ), N(R ^15c )C(=G)X ⁴ , N(R ^15c )(C( = 0)) ₂ X ⁴ , N{R ¹ - ^¾ ){C( = 0)) ₂ OX _f N(R ^1¾ )(C{ = 0)) ₂ N(R ^15c )X ⁴ ,

N(R ^15c )C(- 0)N{R ^15c )C{- 0)0(R ^15c ) _; N{R ^15C )(C(-0)0{Ci-C6)alkyl), N(R ^15C )(C{-0)0{Ci-C ₆ ) haioa!ky!3, N((Ci-C ₃ )alkylOC( =0)(Ci- C6)al l), N((Ci-C ₃ )alkylO(Ci- C ₆ )a! kyi) _f and N(R ^15c )C( = S)X ⁴ ,

( 1) said R ^{t c} is each i ndependently selected from the group consisting of H, (Ci-C ₃ )alkyl, (C ₂ -C ₃ )ai kenyi, (C ₂ - C ₃ )aikynyi, (Ci-C ₃ )haloalkyi, (C ₂ ~C ₃ )haloaikenyi, (Ci- C ₃ )a!kylphenyi, (Ci-C ₃ )a!ky!Q(Ci-C ₃ )aikyl, (Ci- C ₃ )a!kyiOC{-0)(Ci-C ₃ )alkyi, C( -0)(Ci-C ₃ )ai kyl, and phenyl, optionally, for N(R ^15c ) ₂ said N(R ^15c ) ₂ Is a heterohydrocarbyi ring contai ning one nitrogen ring atom and three to five carbon ring atoms, where said ring may be saturated or unsaturated,

(2) said X ⁴ is selected from the group consisting of (Ci- Cejaikyl, (Ci-C6)haloalkyl, (Ci-C ₃ )a!kylO(Ci-C ₃ )aikyl, 0(G- Coja i ky!, (C ₃ -C6)cycloalkyl, (Ci-C6)ai kylphenyl, phenyl, aryl, and heterocyciyi, each of which may be substituted with one or more of substituents selected from the group consisting of F, CI, Br, I, CN, OH, N0 ₂ , N H ₂ , oxo, (Ci~C ₃ )aikyl, (Ci- C ₃ )haloalkyl _f NH(Ci~C ₃ )aikyl, N((Ci-C ₃ )alky!) ₂ , 0(Ci~C6)aikyl, 0(Ci-Cs)haloalkyl,

N(R ^15c )S( =0) ₂ (R ^15c ), S( =0) ₂ (R ^15C ), (Ci-C ₃ )alkyiO(Ci-C ₃ )alkyi,

wherein ( l)(a) and (l)(b) each said alkyl, a! kenyl, a! kynyl, cycloalkyl, phenyl, aryl, and heterocyciyi, may be substituted with one or more substituents selected from the group consisting of F, CI, Br, !, CN, OH, 0 ₂ , NH ₂ , NH(Ci-C ₃ )alkyl, IM((Ci-C ₃ )alkyl) ₂ , 0(Ci- C6)a! kyi, (Ci-C ₃ )alkylO(Ci~C ₃ )alkyl, and (C ₃ -C6)cycioalkyi ;

N(R ^16a )(R ¹⁵ⁱ³ ) wherein

(a) said R ^16a is selected from the group consisting of H, (Ci- C ₃ )ai kyl, (C ₂ -C ₃ )alkenyi, (C ₂ -C ₃ )ai kynyl, (Ci-C ₃ )haioaikyl, (Ci- C ₃ )ai kylO(Ci-C ₃ )aikyl, (Ci-C ₃ )alkylOC( = 0)(Ci-C ₃ )al kyl, and

C(=0)(Ci-C ₃ )alkyl, (b) said R ^16b is a substituted or unsubstituted (Ci-Cs)a!kyi, said substituted (G-Cs)alkyl has one or more substituents selected from the group consisting of F, CI, Br, I, CN, O2, 0(Ci-C8)alkyl, {C3- Cs)cycloalkyl, (Ci-C8)alkylphenyi, (C2-C8)aikenyl _i (Cz-Cs)alkynyl, S{Ci-Cs)alkyl, S(0){Ci-Cs)alkyl, S{0)2(Ci-C ₈ )alkyi, Ophenyl, 0(Cz- Cs)aikenyl, 0{Ci-Cs)alkyl{C3-Cs)cycloaikyi, 0(Ci-Cs)a!kyl phenyl, 0(Ci-C ₈ )alkyl(C3-C8)cycloalkyl, 0(Ci-C ₈ )alkyl, C(-0)0(Ci-C ₈ )a!kyi,

C ₈ )aikyi, S(G~C ₈ )aikyl, S(0)(Ci-C ₈ )aikyi _f SfOMG-CsJalkyl, S{0) ₂ NH2, and (R ⁵⁵³ )S(0)2(Ci-C ₃ )alkyi,

wherein (2)(a) and (2)(b) each aikyi, alkenyi, aikynyl, cycioaikyi, and phenyl, may be substituted with one or more substituents selected from the group consisting of F, C!, Br, I, CN, OH, !NiH2, N0 ₂ , {Ci-C ₈ )a!ky!, (Ci-Ce)alkoxy, (Ci-Ce)haloalkyl, N((Ci-C ₈ )alkyl) ₂ , and C(=0)0(G-C ₈ )alkyl;

N(R ^17a )(N(R ^17b )(R ^17c )) wherein

(a) said R ^17a is selected from the group consisting of H, (Ci~ C ₃ )aikyi, (C ₂ -C ₃ )alkenyi, (C2-C ₃ )aikynyi, (Ci-C ₃ )haioaikyl, (Ci- C ₃ )aikylO(Ci-C ₃ )aiky!,(Ci-C ₃ )aikylOC(-0)(Ci-C ₃ )alkyl, and

(b) said R ^17b Is selected from the group consisting of H, (Ci- C ₃ )aikyl, (C ₂ -C ₃ )alkenyl, (Cz-C ₃ )aikyny!, (Ci-C ₃ )haioaikyl, (Ci- C3)aikyiO(Ci~C3)aikyl,(Ci-C3)aikylOC(=0)(Ci-C3)aiky!, and

C(=0)(Ci-C ₃ )alkyl,

(c) said R ^17c is selected from the group consisting of H, substituted or unsubstituted phenyl, substituted or unsubstituted heterocyciyi, substituted or unsubstituted {Ci-C ₈ )alkyi, substituted or unsubstituted (C3-C ₈ )cycloaikyi, C(-- ^: 0)X ⁵ , and C{-- ^: S)X ⁵ ,

(1) said X ⁵ is selected from the group consisting of substituted or unsubstituted phenyl, substituted or unsubstituted heterocyciyi, substituted or unsubstituted (G- C ₈ )aikyi, 0(Ci-Cs)a!kyi, 0(Ci~Cs)haloaiky!, 0(substituted and unsubstituted)phenyl, N(R ^17a )(Ci-C ₈ )alkyl, N(R ^17a )(G- Cs)haloalkyi, i(R ^17a )(C ₃ -Cs)cycloalkyi, (R ^17a )(substltuted and unsubstituted phenyl), and (C ₃ -C5)cycloa!kyl,

(2) said substituted phenyl in (3)(c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, N02,OH, (G-G alkoxy, and (G-C3)alkyl, (3) said substituted heterocyciyl in (3)(c) has one or more substituents seiected from the group consisting of F, CI, Br, I, CN, NO2, OH, (Ci-C3)aikoxy, and (Ci-C ₃ )alkyi,

(4) said substituted (Ci-Cs)alkyl In (3)(c) has one or more substituents seiected from the group consisting of F, CI, Br, I, CN, OH, NO2, MHz, 0{Ci-C ₈ )alkyi, {C3-Cs)cycloaikyl, phenyl, (C2-Cs)alkenyl, (C2-Cs)alkynyl, S(Ci-Cs)aikyl, S(0)(Ci-Cs)aikyl, S(0)2(Ci-Ca)alkyl, Ophenyl, 0(C ₂ - Cs)aikenyl, 0(Ci-C8)alkyl(C3-Cs)cycloalkyl, 0(Ci~

Cs)aikylphenyl, 0(Ci-C ₈ )aikyl(C3-C3)cycioaikyi, Cs)aikyl, S(0) ₂ NH ₂ , NH(Ci-C ₃ )alkyl, N((Ci-C ₃ )alkyl) _2|

(5) said substituted (C3-Cs)cycloalkyi has one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, (Ci-C ₃ )alkoxy, and (Ci-C ₃ )alkyl,

wherein (2)(a), (2)(b), and (2)(c) each a!kyl, a!keny!, aikyny!, cycioaikyl, haloalkyl, phenyl, and heterocyciyl, may be optionally substituted with one or more substituents selected from the group consisting of F, Ci, Br, I, CN, OH, NH ₂ , NO2, (Ci-Cs)alkyl, (Ci- Cs)aikoxy, (Ci-Cs)haloalkyl, N((Ci-C3)alkyi)2, and C(~ ^: 0)0(Ci- Cs)alkyl, optionally (N(R ^17b )(R ^17c )} is a heterohydrocarbyl ring containing one nitrogen ring atom and three to five carbon ring atoms, where said ring may be saturated or unsaturated;

N(R ^18a )(N=C(R ¹⁸ )(R ^18c )

(a) said R ^18a is selected from the group consisting of H, (G- C ₃ )aikyi, (C2-C ₃ )alkenyi, (C2-C ₃ )aikynyi, (Ci-C ₃ )alkyiO(Ci- C ₃ )alkyl,(Ci-C3)alkylOC( = 0)(Ci-C ₃ )alkyl, and C(=0)(Ci-C ₃ )alkyl,

(b) said R ¹⁸ is selected from the group consisting of H and (G- C ₃ )alkyi,

(c) said R ^18c is selected from the group consisting of substituted or unsubstituted phenyl, substituted or unsubstituted heterocyciyl, substituted or unsubstituted (G~Cs)aikyi, substituted or unsubstituted {C ₃ -Cs)cycioalkyl,

(1) said substituted phenyl in (4)(c) has one or more substituents selected from the group consisting of F, Ci, Br, I, CN, NO2, OH, (Ci-C ₃ )alkoxy, (Ci-C ₃ )alkyl, (Ci- C ₃ )haloalkoxy, and (G-C3)haloalkyl, (2) said substituted heterocyclyl i n (4)(c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, NO2, OH, (Ci-C3)aikoxy, (Ci-C ₃ )aikyl, (Ci- Csjhaloalkoxy, and (Ci-C3)haioalkyi,

(3) said substituted (Ci-Cs)a!kyl has one or more substituents selected from the group consisting of F, CI, Br, I, CN, NO2, 0(Ci-C8)a!kyi, (C3-Cs)cyc!oa!kyl, phenyl, (C2- Cs)aikenyl, (C2-Cs)alkynyl, S(Ci-C8)alkyl, S(G)(Ci-C ₈ )alkyi, S(0)2(Ci-Cs)al kyi, ©phenyl, 0(C2-Ca)aikenyl, 0(Ci~

Cs)aikyl(C3-Cs)cycioai kyl, 0(Ci-C8)alkylphenyi, 0(Ci- Cs)alkyl(C3-Cs)cycloal kyl,

NHC( =0)(Ci-C ₈ )alkyl, and S(0) ₂ NH2,

(4) said substituted (C3-Cs)cycloalkyi has one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, (Ci-C ₃ )alkoxy, and (Ci-C ₃ )a! kyL

wherein (4)(a), (4)(b), and (4)(c) each aikyl, aikeny!, ai kynyl, cycloalkyl, haloalkyl, phenyl, and heterocyclyl may be substituted with one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, NH ₂ , NO2, (Ci-Cs)alkyl, (Ci-Cs)a!koxy, (Ci- Ce) aloalkyl, N((Ci-C8)alkyi)2, and C( =0)0(Ci-Cs)al kyl, optionally C(R ^18b )(R ^18c ) is a hydrocarbyl ring containing three to five carbon ri ng atoms, where said ring may be saturated or unsaturated, optionally, one or more of said carbon ri ng atoms may instead be nitrogen, oxygen, or sulfur atom;

and N-oxides, agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, crystal polymorphs, isotopes, resolved stereoisomers, tautomers, pro-insecticides, of the molecules of Formula One.

A molecule according to detail 1 wherein :

(A) R ¹ Is selected from the group consisti ng of H, F, CI, Br, I, CN, NOz, SF5, and (Ci-C3)haloalkyl ;

(B) R ² Is selected from the group consisti ng of H, F, CI, Br, I, CN, NO2, SF5, and (Ci~C3)haloaikyi ;

(C) R ³ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, SF5, and (Ci-C3)haloalkyi ;

(D) R ⁴ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, SF5, and {Ci-C3)haloalkyi ;

(E) R ⁵ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, SF5, and (Ci-C3)haloalkyi ; (F) R ⁶ is H;

(G) R ⁷ is selected from the group consisting of F, CI, and Br;

(H) R ⁸ is seiected from the group consisting of F, CI, and Br;

(I) R ⁹ is H;

(J) Q ¹ is selected from the group consisting of 0 and S;

(K) Q ² is selected from the group consisting of 0 and S;

(L) R ¹⁰ is seiected from the group consisting of H, (C1-C3) alky!, (Cz-

C3)aikenyi, (C?.-C3)alkyny! _f (G-C3)alkylO(Ci-C3)alkyl, and

C3)aikyi;

(Ml) R ¹¹ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, (Ci- Cs)aikyi, (Ci-C3)haloalkyi, and (Ci-C3)aikoxy;

( ) R ¹² is selected from the group consisting of H, F, CI, Br, I, CN, NO2, (d- C3)alkyl, (Ci-C3)haloalkyl, and (Ci-C3)alkoxy;

(O) R ¹³ is selected from the group consisting of H, F, CI, Br, I, CN, NO2, (Ci- Csjalkyl, (G-C3)haloalkyl, and (Ci-C3)alkoxy;

(F) R ¹⁴ is seiected from the group consisting of H, F, CI, Br, I, CN, NO2, (Ci~ C3)alkyi, (Ci-C3)haloalkyl, and (Ci-C3)a!koxy;

(Q) X ³ is:

(1) N(R ^15a )(R ^15b ) wherein

(a) said R ^15a is selected from the group consisting of H, (Ci- C ₃ )aikyl, (C ₂ -C ₃ )a!kenyi, (Cz-O alkynyl, (Ci-C ₃ )haioaikyl, (G- C ₃ )alkylphenyl, (Ci-C ₃ )alkylO(Ci-C ₃ )alkyl,

C3)alkyl, and and

(b) said R ¹⁵ Is a substituted or unsubstituted phenyl, said substituted phenyl has one or more substituents seiected from the group consisting of H, F, CI, Br, I, CN, NO2, NH ₂ , OH, SF ₅ , (G- C ₃ )alkyi, (G-C3)ba!oalkyl, (C2-C3)alkenyl, {C2-C ₃ )haloalkenyi, (G- C ₃ )alkoxy, (C=0)0(Ci-C ₃ )alkyl, 0(C=0)(Ci-C ₃ )alkyl, N(R ¹⁵ ) ₂ ,

N = CHN(R ^15c )(X ⁴ ), N(R ^15C )C(-0)0(X ⁴ ), N(R ^15c )S( = 0)z(X ⁴ ), N(S(=OMG-C ₃ )alkyl) ₂ , N(R ^15c )C{-0}N(R ^15c ) ₂ ,

N(R ^15c )C( = 0)N(R ^15c )X ⁴ , N(R ^15c )C( = S)N(R ^15c ) ₂ ,

N(R ^15c )C(=S)N(R ^1¾ )X ⁴ , N(R ^1¾ )(Ci-C3)alkylX ⁴ , N(R ^15c )(CH(0(G- C3)aikyi) ₂ ), N(R ^15c )({Ci-C ₃ )aikyiOC{=0)(Ci-C3)alkyi), N(R ^15c )((G~

N(R ^15c )(C(-0)) ₂ X ⁴ , N(R ^15c ){C(-0))20X ⁴ , N(R ^15c )(C{-0))2N(R ^15c )X ⁴ ,

N(R ^1¾ )C(=0)N(R ^15c )C( = 0)0(R ^15c ), ( R' ^¾ ) (C( -0)0{ C , · Co)a I kyl ), N(R ^15C )(C(=0)0(Ci-C6)haioaikyl), N((Ci-C ₃ )alkylOC(=0)(Ci-

C6)a!kyi)(C(=0)0(Ci-C6)a!kyi),and N(R ^15c )C( = S)X ⁴ ,

(1) said R ^15c is each independenty selected from the group consisting of H, (Ci-C3)alkyl, (C2-C ₃ )alkenyl, {C2- C3)alkynyl, (Ci-C3)haloalkyl, (C2-C3) aloalkenyl, (Ci- C ₃ )aikylphenyl _f (Ci-C ₃ )aikyiO{Ci-C ₃ )a!kyl, (Ci- and phenyl, optionally, for N(R ^15c )2said N(R ^15c )2is a heterohydrocarbyl ring containing one nitrogen ring atom and three to five carbon ring atoms, where said ring may be saturated or unsaturated,

(2) said X ⁴ is selected from the group consisting of (Ci- Cejalkyl, (G-C5)haloa!ky!, (Ci-C ₃ )alkyiO{Ci-C ₃ )alkyl, 0(Ci- Ce)alkyl, (C3-C6)cycioaikyl, (Ci-C6)alkylphenyl, phenyl, aryi, and heterocyciyl, each of which may be substituted with one or more of substituents selected from the group consisting of F, CI, Br, I, CM, OH, NO2, H2, oxo, (Ci-C ₃ )a!kyi, (Ci- C ₃ )haloalkyi, NH(Ci-C3)alkyl, N((Ci-C3)alkyl) ₂ , 0(Ci-Cs)aikyl, 0(Ci-C ₆ )haloalkyl,

rsi(R ^15c )S(-0) ₂ {R ^15c ), S(=0) ₂ (R ^15c ), (Ci-C3)alkylO(Ci-C ₃ )alkyl, (C3-C6)cydoalkyl,

wherein (l)(a) and (l)(b) each said aikyl, aikenyl, a!kynyi, cycloalkyi, phenyl, aryi, and heterocyciyl, may be substituted with one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, O2, NH ₂ , NH(Ci-C ₃ )alkyl, N((Ci-C ₃ )alkyl)z, 0(Ci- C ₆ )aikyi, (Ci-C3)alkyiO(Ci-C ₃ )alkyl, and (OCejCycioalkyl;

N(R ^16a )(R ^16b ) wherein

(a) said R ^16a is selected from the group consisting of H, (Ci- C ₃ )alkyi, (Cz-C ₃ )alkenyl, (C ₂ -C ₃ )alkynyl, (Ci-C ₃ )haloalkyl, (O

C ₃ )alkylO(Ci-C ₃ )alkyl, (Ci-C ₃ )alkylOC(=0)(Ci-C ₃ )alkyl, and

(b) said R ^16b Is a substituted or unsubstituted (Ci-Cs)alkyl, said substituted (Ci-Cs)alkyl has one or more substituents selected from the group consisting of F, CI, Br, I, CN, O2, 0(Ci-Cs)alkyl, (C ₃ - Cs)cyc!oalkyl, (Ci-Cs)alkylphenyl, (C2-Cs)alkenyl, (C2-Cs)alkynyl, S(Ci-Cs)alkyl, S(0)(Ci-C8)alkyl, S(0)2(Ci-C8)alkyl, Ophenyl, 0(Cz- Ci3)aikenyl, 0(Ci-C8)alky!(C ₃ -C8)cycloaikyi, 0(Ci-Cs)alkyl phenyl, 0(Ci~Cs)alkyi(C ₃ ~C8)cycloalkyl, 0(Ci-Cs)alkyl, C(=0)0(Ci-Cs)alkyl,

C ₈ )a! kyi, S(Ci-Ca)a!ky! _f S(0)(Ci-C ₈ )al kyl, S(0)2(Ci-Cs)alkyl,

5{0) ₂ Ν Η ₂ , and N(R ^15a )S(0)2(Ci~C ₈ )aikyi,

wherein (2)(a) and (2)(b) each ai kyi, ai kenyi, alkynyi, cycioaikyi, and phenyl, may be substituted with one or more substituents selected from the group consisti ng of F, CI, Br, I, CN, OH, M Hz, NOz, (Ci-C ₈ )alkyl, (Ci-Ce)alkoxy, (Ci-Cs)ha!oal kyl, N((Ci-C ₈ )alkyl)2,

N(R ^17a )(N(R ^i7b )(R ^17c )) wherein

(a) said R ^17a is selected from the group consisting of H, (Ci- C ₃ )ai kyl, (C2-C ₃ )alkenyi, (C2~C ₃ )ai kynyl, (Ci-C ₃ )haioaikyl, (Ci- C ₃ )ai kyiO{Ci-C ₃ )aikyl,(Ci-C ₃ )aikylOC{-0)(Ci-C ₃ )alkyi, and

C(=0)(Ci-C ₃ )alkyl,

(b) said R ¹⁷ Is selected from the group consisting of H, (Ci- C ₃ )al kyi, (Cz-C ₃ )alkenyl, (C ₂ -C ₃ )al kynyi, (Ci-C ₃ )haloalkyl, (Ci- C ₃ )a! kyiO(Ci-C ₃ )a!kyl,(Ci-C ₃ )alkylOC(=0)(Ci-C ₃ )alkyi, and

(c) said R ^17c is selected from the group consisting of H, substituted or unsubstituted phenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted (Ci-Cs)alkyi, substituted or unsubstituted (C3-C ₈ )cycloalkyl, C(=0)X ⁵ , and C( ^~ S)X ⁵ ,

(1) said X ⁵ is selected from the group consisting of substituted or unsubstituted phenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted (Ci- Cs)aikyl, 0(Ci~C ₈ )ai kyi, 0(Ci-C ₈ )haloalkyl, 0(substituted and unsubstituted)phenyl, N(R ^17a )(Ci-C ₈ )al kyl, N(R ^17a )(Ci~ Cs)haloalkyi, IM(R ^17a ){C ₃ -C ₈ )cycloalkyi, N (R ^17a )(substltuted and unsubstituted phenyl), and (Cs-Ce yc!oalkyi,

(2) said substituted phenyl in (3){c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, NO2, OH, (Ci-C ₃ )aikoxy, and (Ci-C ₃ )alkyi,

(3) said substituted heterocyclyl i n (3)(c) has one or more substituents selected from the group consisti ng of F, CI, Br, I, CN, NO2, OH, (Ci-C ₃ )aikoxy, and (Ci-C ₃ )alkyi,

(4) said substituted (Ci-Cs)a!kyi in (3)(c) has one or more substituents selected from the group consisti ng of F, CI, Br, I, CN, OH, NO2, NHz, 0(Ci-C ₈ )alkyi, (C ₃ -C ₈ )cycloaikyl, phenyl, (C2-C ₈ )a!kenyi, (C2-C ₈ )ai kynyl _f S(Ci~C ₈ )aikyl, S(0)(Ci-Cs)alkyl, S(Q)2(Ci~Cs)aikyl, Ophenyl, 0(Cz- Cs)aikeny! _f 0(Ci-C8)a!kyi(C3-C8)cycloaikyl, 0(Ci- C ₈ )aikylphenyi, 0{Ci-Cs)a!kyl{C ₃ -C8)cyc!oaikyi _i

Cs)alkyl, NHC(=0)(Ci-Cs)alkyl, S(Q)2NH ₂ , NH(Ci-C ₃ )alkyl,

(5) said substituted (C3-Cs)cyc!oa!ky! has one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, (Ci~C3)aikoxy, and (Ci-C3)alkyl,

wherein (2)(a), (2)(b), and (2)(c) each aikyl, aikenyi, alkynyi, cycioaikyi, haioaikyl, phenyl, and heterocyciyi, may be optionally substituted with one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, NH ₂ , N0 ₂ , (Ci-Cs)alkyl, (Ci- Cs)alkoxy, (Ci-Csjbaioaiky!, N({Ci-Cs)alkyl)2, and C{ ^~ 0)0(Ci- Cs)alkyi, optionally (N(R ¹⁷ )(R ^17c )) is a heterohydrocarbyl ring containing one nitrogen ring atom and three to five carbon ring atoms, where said ring may be saturated or unsaturated; and N(R ^18a )(N=C(R ¹⁸ )(R ^18c ))

(a) said R ^18a is selected from the group consisting of H, (Ci- C3)aikyl, (C2-C ₃ )alkenyi, (C2-C3)alkynyl, (Ci-C ₃ )alkyiO{G-

(b) said R ^18b is selected from the group consisting of H and (Ci- C )aikyl,

(c) said R ^18c is selected from the group consisting of substituted or unsubstituted phenyl, substituted or unsubstltuted heterocyciyi, substituted or unsubstituted (Ci-Cs)aikyi, substituted or unsubstltuted (Cs-Cs ycioaikyl,

(1) said substituted phenyl in (4){c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, ΝΟζ,ΟΗ, (Ci-C ₃ )alkoxy, (Ci-C ₃ )aikyi, (Ci- C ₃ )haloa!koxy, and (Ci-C ₃ )haloalkyi,

(2) said substituted heterocyciyi in (4)(c) has one or more substituents selected from the group consisting of F, CI, Br, I, CN, NO2, OH, (Ci-C3)aikoxy, (Ci-C ₃ )aikyl, (Ci- C ₃ )haloalkoxy, and (Ci-C3)haioalkyi,

(3) said substituted (Ci-Cs)a!kyl has one or more substituents selected from the group consisting of F, CI, Br, I, CN, NO2, 0(Ci-C8)a!kyi, (C ₃ -Cs)cyc!oa!ky!, phenyl, (C2- Cs)aikenyl, (C2-Cs)aikynyi, S(Ci-Cs)alkyl, S(0)(Ci-Cs)aiky!, S(0)2(Ci-Cs)ai ky!, Ophenyi, 0(C2~Cs)aikenyl, 0(G- Cs)aiky! (C3-Cs)cycioa! kyi, 0(Ci ~Cs)alky!phenyi, 0(Ci- C8)a l kyl (C3-Cs)cycloal kyl, C(=O) N H{Ci~C ₈ )a!kyi,

NHC(=0) (Ci-C ₈ )aikyi, and S(0) ₂ NH _2;

(4) said substituted (C3-Cs)cyc!oa!ky! has one or more substituents selected from the group consisting of F, CI, Br, I, CN, OH, (OC ₃ )a!koxy, and (Ci-C ₃ )al kyl,

wherein (4) (a), (4)(b), and (4)(c) each aikyl, aikenyi, ai kynyi, cycioaikyi, haioaikyl, phenyl, and heterocyclyl may be substituted with one or more substituents selected from the group consisting of F, CI , Br, I, CN, OH, N H ₂ , NQz, (Ci-Cs)aikyl, (Ci-C ₈ )alkoxy, (Ci- Cs)haloaikyl, N ({Ci-Cs)alkyl)2, and C{ ^: --0)0{Ci-Cs)al kyl, optionally C(R ^iS )(R ^18c ) is a hydrocarbyl ring containing three to five carbon ri ng atoms, where said ring may be saturated or unsaturated, optionally, one or more of said carbon ri ng atoms may instead be nitrogen, oxygen, or sulfur atom,

A molecule according to previous detai ls 1 and 2 wherein said molecule has the followi ng formula

Formula Two

4. A molecule according to any of the previous details wherei n R ¹ Is selected from the group consisting of H, F, CI, Br, SFs, and CF3.

5. A molecule according to any the previous details wherei n R ² is selected from the group consisti ng of H, F, CI, Br, SF5, and CF3.

6, A molecule according to any of the previous details wherei n R ³ Is selected from the group consisting of H, F, CI, Br, SF5, and CF3.

7, A molecule according to any of the previous details wherei n R ⁴ is selected from the group consisting of H, F, CI , Br, SF5, and CF3.

8. A molecule according to any of the previous details wherei n R ⁵ is selected from the group consisting of H, F, CI, Br, SF5, and CF3.

9. A molecule according to any of the previous details wherei n at least one of R ² , R ³ , and R ⁴ , Is SF ₅ . 10. A molecule according to any of the previous details wherein R ⁷ is CI.

11. A molecule according to any of the previous details wherein R ⁸ is CI.

12. A molecule according to any of the previous details wherein R ⁷ and R ⁸ are not the same.

13. A molecule according to any of the previous details wherein Q ¹ is 0,

14. A molecule according to any of the previous details wherein Q ² is 0,

15. A molecule according to any of the previous details wherein R ¹⁰ is H.

16. A molecule according to any of the previous details wherein R ¹¹ is H.

17. A molecule according to any of the previous details wherein R ¹² is selected from the group consisting of H, F, CI, CH3, and CF3.

IS. A molecule according to any of the previous details wherein R ¹³ is selected from the group consisting of F, CI, CH3, and OCH3.

19. A molecule according to any of the previous details wherein R ¹⁴ is selected from the group consisting of H, F, and CI.

20. A molecule according to any of the previous details wherein:

R ¹ is selected from the group consisting of H, F, CI, Br, SF5, and CF3;

R ² is selected from the group consisting of H, F, CI, Br, SF5, and CF3;

R ³ is selected from the group consisting of H, F, CI, Br, SFs, and CF3;

R ⁴ is selected from the group consisting of H, F, CI, Br, SFs, and CF ₃ ;

R ⁵ is selected from the group consisting of H, F, CI, Br, SF5, and CF ₃ ;

R ⁷ Is CI;

R ⁸ Is CI;

Q ^"1 is 0;

Q ² is 0;

R ¹⁰ is H;

R ¹¹ is H;

R ¹² Is selected from the group consisting of H, F, CI, CH3, and CF3;

R ¹³ Is selected from the group consisting of F, CI, CH3, and OCH3; and

R ¹⁴ Is selected from the group consisting of H, F, and CI,

21. A molecule according to any of the previous details, 1 through 20 inclusive,

wherein X ³ is N(R ^15a )(R ^15b ),

said R ^15b is selected from the group consisting of N(R ^15c )C(=0)(R ^{1 c} ) and N(R ^15c )C( = Q)X ⁴ ,

said R ^15c are each independently selected from the group consisting of (Ci- C3)aikyi, (C2-C3)alkenyl, (Ci-C3)haloalkyl, and (Ci-C3)alkylO(Ci-C3)alkyl,

said X ⁴ is selected from the group consisting of (Ci-Cejalkyl, (Ci- C ₆ ) aloalkyl, and (Ci-C ₃ )alkylO(Ci-C3)alkyl, wherein each said aiky!, haioalkyi, and a!kenyl, may be substituted with one or more substituents selected from the group consisting of F, CI, CN, and (Cs- Ce ydoalkyi ,

22. A molecule according to any of the previous details, 1 through 20 inclusive,

wherein X ³ is N( ^15a )(R ^15b ) and R ^i5b is N(R ^15c )C(C=0)X ⁴ ) .

23. A molecule according to any of the previous details, 1 through 20 inclusive,

wherein X ³ is N(R ^16a )(R ^16b ) .

24. A molecule according to any of the previous details, 1 through 20 inclusive, wherein X3 is N(R ^17a )(N (R ¹⁷ )(R ^17c )) .

25. A molecule according to any of the previous details, 1 through 20 inclusive,

wherein X ³ is N(R ^1Sa )( =C(R ^1Sb ){R ^iSc ) ,

26. A molecule selected from Table 2, preferably a molecule selected from the group consisti ng of F1007, F1079, F1108, F1147, F1185, F1234, F1241, F1246, F1247, F1248, F1250, F1460, F1465, F1593, F1598, F1613, F1627, F1657, F1694, F1696, F1697, F1702, F1703, F1704, F1708, F1711, F1740, F2016, F2017,

F2021, F2027, F2039, F2042, F2078, and F2081.

27. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient,

28. A composition comprising a molecule accordi ng to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient selected from the group consisti ng of acaricides, alglcldes. antifeedants, avlcldes. bactericides, bird repellents, chemosterilants, fungicides, herbicide safeners, herbicides, Insect attractants, insect repellents, insecticides, mammal repellents, mating disrupters, molluscicides, nematicides, plant activators, plant growth regulators,

rodenticides, synergists, and virucldes.

29. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient selected from AIGA.

30. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising AI- 1.

31. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising Lotilaner.

32. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising a molecule selected from Tafofe A.

33. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient selected from

34. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising chiorpyrifos. 35. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising hexafiumuron.

36. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising methoxyfenozide.

37. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising novif! umuron.

38. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising spinetoram.

39. A composition comprising a moiecuie according to any of the previous details, i through 26 inclusive, further comprising spinosad .

40. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising su!foxaflor,

41. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient selected from AIGA- 2.

42. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising acequinocyi ,

43. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising acetami prid .

44. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising acetoprole.

45. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising avermectin.

46. A composition comprising a moiecuie according to any of the previous details, 1 through 26 inclusive, further comprising azinphos-methyl .

47. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising bifenazate.

48. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising bifenthrin.

49. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising carbaryl .

50. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising carbofuran.

51. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising chiorfenapyr,

52. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising chlorfluazuron. 53. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising chromafenozide.

54. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising ciothianidin.

55. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising cyfluthrln,

56. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising cypermethrm.

57. A composition comprising a moiecuie according to any of the previous details, i through 26 inclusive, further comprising deltamethrin.

58. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising diafenthiuron.

59. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising emamectin benzoate.

60. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising endosulfan,

61. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising esfenvalerate.

62. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising ethiprole.

63. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising etoxazole.

64. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising flpronli .

65. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising flonicamld ,

66. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising fluacrypyri m.

67. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising gamma-cyhalothrin.

68. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising halofenozide.

69. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising indoxacarb,

70. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising /amdda -cyhaiothrin.

71. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising lufenuron. 72. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising malathion.

73, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising methomyi ,

74, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising nova!uron.

75, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising permethrin,

76. A composition comprising a molecule according to any of the previous details, i through 26 inclusive, further comprising pyridaiyi .

77, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising pyri midifen.

78. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising spirodiclofen.

79. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising tebufenozlde.

SO. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising thiacioprid,

81, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising thiamethoxam.

82, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising thiodicarb.

83, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising tolfenpyrad .

84. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising zefa-cypermethr!n,

85. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising a biopesticide.

86. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from

Acetylcholinesterase (ACHE) inhibitors,

87. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from GABA-gated chloride channel antagonists,

88, A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Sodium channel modulators. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Nicotinic acetylcholine receptor (nAChR) agonists.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Nicotinic acetylcholine receptor (nAChR) aiiosteric activators.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Chloride channel activators.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Juvenile hormone mimics,

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Miscellaneous nonspecific (multi-site) inhibitors.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Modulators of Chordotonai Organs.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Mite growth inhibitors.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Microbial disruptors of insect midgut membranes.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Inhibitors of mitochondrial ATP synthase.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Uncoupiers of oxidative phosphorylation via disruption of the proton gradient.

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Nicotinic acetylcholine receptor (nAChR) channel blockers,

A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Inhibitors of chitin biosynthesis, type 0, 101. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Inhibitors of chitin biosynthesis, type 1.

102. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Moulting disrupter, Dipteran.

103. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Ecdysone receptor agonists,

104. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Octopamsne receptor agonists.

IDS. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Mitochondrial complex III electron transport inhibitors.

106. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Mitochondrial complex I electron transport inhibitors.

107. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Voltage- dependent sodium channel blockers.

108. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Inhibitors of acetyl CoA carboxylase.

109. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Mitochondrial complex IV electron transport inhibitors.

110. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Mitochondrial complex II electron transport inhibitors.

111. A composition comprising a moiecuie according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Ryanodine receptor modulators.

112. A composition comprising a molecule according to any of the previous details, 1 through 26 inclusive, further comprising an active ingredient from Group UN.

113. A composition according to any of the previous details, 27 through 112 inclusive, wherein the weight ratio of the moiecuie according to Formula One or Formula Two to the active ingredient is 100:1 to 1:100, 114. A composition according to any of the previous details, 27 through 112 Incl usive, wherein the weight ratio of the molecule according to Formula One or Formula Two to the active ingredient is 50 : 1 to 1 : 50.

115. A composition according to any of the previous details, 27 through 112 i nclusive, wherein the weight ratio of the molecule according to Formula One or Formula

Two to the active ingredient is 20 : 1 to 1 : 20.

116. A composition according to any of the previous details, 27 through 112 inclusive, wherein the weight ratio of the molecule according to Formula One or Formula Two to the active ingredient is 10 : 1 to 1 : 10.

117. A composition according to any of the previous details, 27 through 112 i nclusive, wherein the weight ratio of the molecule accordi ng to Formula One or Formula Two to the active ingredient is 5 : 1 to 1 : 5,

118. A composition according to any of the previous details, 27 through 112 i nclusive, wherein the weight ratio of the molecule according to Formula One or Formula Two to the active ingredient is 3 : 1 to 1 : 3.

119. A composition according to any of the previous details, 27 through 112 i nclusive, wherein the weight ratio of the molecule according to Formula One or Formula Two to the active ingredient is 2 : 1 to 1 : 2,

120. A composition according to any of the previous details, 27 through 112 i nclusive, wherein the weight ratio of the molecule according to Formula One or Formula

Two to the active ingredient is 1 : 1.

121. A composition according to any of the previous details, 27 through 112 i ncl usive, wherein the weight ratio of the molecule according to Formula One or Formula Two to the active ingredient is X; Y; wherein X is the pasts by weight of the molecule of Formula One or Formula Two, and Y is the parts by weight of the active ingredient; further wherein the numerical range of the parts by weight for X is 0 < X≤ 100 and the parts by weight for Y is 0 < Y≤ 100; and further wherein X and Y are selected from Table C.

122. A composition accordi ng to 121 wherein a range of weight ratios of the molecule of Formula One or Formula Two to the active Ingredient Is Xi i Yi to Xz '. Yz) further wherein Xi > Yi and Xz < Y2.

123. A composition according to 121 wherein a range of weight ratios of the molecule of Formula One or Formula Two to the active ingredient Is Xi i Yi to Xz '. Yz; further wherein Xi > Yi and Xz > Y2.

124. A composition according to 121 wherein a range of weight ratios of the molecule of Formula One or Formula Two to the active Ingredient is X . Yi to Xr. Yr, further wherein Xi < Yi and Xz < Yz. 125. A process to produce a composition, said process comprising mixing a moiecuie according to any one of previous details, 1 through 26 inclusive, with one or more active ingredients,

126. A seed treated with a molecule according to any of the previous details, 1 through 26 inclusive,

127. A moiecuie according to any of the previous details, 1 through 26 inclusive,

wherein said moiecuie is in the form of agriculturally acceptable acid addition salt,

128. A moiecuie according to any of the previous details, 1 through 26 inclusive,

wherein said moiecuie is in the form of a salt derivative,

129. A moiecuie according to any of the previous details, 1 through 26 inclusive, wherein said molecule is in the form of solvate,

130. A molecule according to any of the previous details, 1 through 26 inclusive,

wherein said molecule is in the form of an ester derivative,

131. A molecule according to any of the previous details, 1 through 26 inclusive,

wherein said molecule is in the form of a crystal polymorph,

132. A mo!ecuie according to any of the previous details, 1 through 26 inclusive,

wherein said molecule has deuterium, triti um, radiocarbon, or a combination thereof,

133. A moiecuie according to any of the previous details, 1 through 26 inclusive,

wherein said moiecuie is in the form of one or more stereoisomers,

134. A moiecuie according to any of the previous details, 1 through 26 inclusive,

wherein said moiecuie is in the form of a resolved stereoisomer,

135. A process to control a pest said process comprising applying to a locus, a

pesticidaily effective amount of a moiecuie according to any of the previous details, 1 through 26 inclusive.

136. A process to control a pest said process comprising applying to a locus, a

pesticidaily effective amount of a composition according to any of the previous details, 27 through 112 inclusive,

137. A process accordi ng to details 135 and 136 wherein said pest Is selected from the group consisti ng of ants, aphids, bed bugs, beetles, bristietails, caterpillars, cockroaches, crickets, earwigs, fleas, flies, grasshoppers, grubs, leafhoppers, lice, locusts, maggots, mites, nematodes, planthoppers, psyl llds, sawfiles, scales, silverfish, slugs, snails, spiders, springtails, stink bugs, symphylans, termites, thrlps, ticks, wasps, whiteflies, and wireworms.

138. A process accordi ng to details 135 and 136 wherein said pest is selected from Subphyfa Che icerata, yriapoda, or Hexapoda .

139. A process accordi ng to details 135 and 136 wherein said pest Is selected from Qass of Arachnsda, Syrrsphyla, or Insecta, 140, A process accordi ng to details 135 and 136 wherein said pest Is selected from

141. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order Coieoptera.

142. A process accordi ng to details 135 and 136 wherein said pest is selected from Order Dermaptera,

143. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order B!attaria,

144. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order Dsptera.

145. A process accordi ng to details 135 and 136 wherein said pest is selected from Order Hemsptera.

146. A process accordi ng to details 135 and 136 wherein said pest is selected from Order Hymenoptera.

147. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order Isoptera.

148. A process accordi ng to detaiis 135 and 136 wherein said pest Is selected from

149. A process accordi ng to details 135 and 136 wherein said pest is selected from Order Nailophaga .

150. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order Orthoptera.

151. A process accordi ng to details 135 and 136 wherein said pest is selected from Order Psocoptera ,

152. A process accordi ng to details 135 and 136 wherein said pest is selected from

153. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order Thysanoptera.

154. A process accordi ng to details 135 and 136 wherein said pest Is selected from Order Thy sanura ,

155. A process accordi ng to detaiis 135 and 136 wherein said pest Is selected from Order Acarina.

156. A process accordi ng to details 135 and 136 wherein said pest is selected from 157. A process accordi ng to details 135 and 136 wherein said pest is selected from Cfass Symphyia .

159. A process accordi ng to details 135 and 136 wherein said pest Is selected from Subclass CoSfembola , 160. A process according to details 135 and 136 wherein said pest is seiected from Phylum Nematode.

161. A process accordi ng to details 135 and 136 wherein said pest Is seiected from Phylum NoHusca.

162. A process accordi ng to details 135 and 136 wherein said pest is a sap -feedi ng pest.

163. A process accordi ng to details 135 and 136 wherein said pest is selected from aphids, ieafboppers, moths, scales, thrips, psyllids, mealybugs, sti nkbugs, and whltef!ies,

164. A process accordi ng to details 135 and 136 wherein said pest is seiected from Orders Anoplura and Hemi ptera .

165. A process accordi ng to details 135 and 136 wherein said pest Is seiected from Auiacaspis spp. , Aphrophora spp., Aphis spp., Bemisia spp. , Coccus spp. , Euschistus spp. , Lygus spp., Macrosiphum spp., Nezara spp. , and Rhopalosiphum spp.

166. A process accordi ng to details 135 and 136 wherein said pest Is a chewing pest.

167. A process accordi ng to details 135 and 136 wherein said pest Is seiected from caterpillars, beetles, grasshoppers, and locusts.

168. A process accordi ng to details 135 and 136 wherein said pest is selected from Coleoptera and Lepldoptera .

169. A process accordi ng to details 135 and 136 wherein said pest Is selected from Anthonomus spp., Cerotoma spp., Chaetocnema spp., Colaspis spp., Cyclocepha!a spp. , Diabrotica spp, , Hypera spp. , Phy!iophaga spp. , Phyi!otreta spp.,

Sphenophorus spp. , Sitophiius spp.

170. A process accordi ng to details 135 and 136 wherein said locus is where aifaifa, almonds, apples, barley, beans, canola, corn, cotton, crucifers, lettuce, oats, oranges, pears, peppers, potatoes, rice, sorghum, soybeans, strawberries, sugarcane, sugar beets, sunflowers, tobacco, tomatoes, wheat, and other val uable crops are growing or the seeds thereof are planted.

171. A process according to detaiis 135 and 136 wherei n said locus is where plants genetically modified to express specialized traits are planted.

172. A process accordi ng to details 135 and 136 wherein said applying is done to the foliar and/or fruiting portions of plants,

173. A process accordi ng to details 135 and 136 wherein said applying is done to the soi l ,

174. A process accordi ng to details 135 and 136 wherein said applying is done by drip irrigation, furrow app!ication, or pre- or post-planting soil drench. 175. A process accordi ng to details 135 and 136 wherein said applying is done to the foliar and/or fruiting portions of plants, or by treating the seeds of a piant before planti ng.

176. A process comprising applying a moiecuie according to any of the previous detail details, 1 through 26 inclusive, to a locus that includes a non-human animal to control endoparasites, ectoparasites, or both.

The headings in this document are for convenience on!y and must not be used to interpret any portion hereof.

T

Tabfe 2, Structure and preparation method for F Series molecules

514

515

516

517

518

519

520

521

522

523

524

525

526

527

528

529

530

531

532

533

534

535

536

537

538

539

540

541

542

543

544

545

546

547

548

549

550

551

552

553

554

555

556

557

558

559

560

561

562

563

564

565

ĵ66







570

571

572

573

574

575

ĵ76

ĵ77





580

581

582

583

584

585

ĵ86

ĵ87

ĵ88



590

591

592

593

594

595

ĵ96

ĵ97

ĵ98

ĵ99

600

601

602

603

604

605

606

607

608

609

610

611

612

613

614

615

616

617

618

619

620

621

622

623

624

625

626

627

628

629

630

631

632

633

634

635

636

637

638

639

640

641

642

643

644

645

646

647

648

649

650

651

652

653

654

655

656

657

658

659

660

661

662

663

664

665

666

667

668

669

670

671

*prepared according to example number

Table 3. Structure and preparation method for DP Series molecules

673

674

675

676

Ķ77





680

681

682

683

684

685

686

Ķ87

Ķ88



690

691

692

693

694

695

696

Ķ97

Ķ98

Ķ99

700

701

702

703

704

705

706

707

708

709

710

711

712

713

714

715

716

717

718

719

720

721

722

723

724

725

726

727

728

^prepare d according to exam pie number

fabfe 5: l Analytical! data for m olecuies in Table - I

Cmpd. mp

IR (cm ^"1 ) Mass Spec HMR. (¾, ⁱ³ C _? ⁱ⁹ F) No. (°C)

^J H NMR (400 MHz, Acetone-c e) δ 10,23 (s, 1 H), 9.46 (s, 1H), 8.19 (td, J - 9.0, 6.0 Hz, IH), 8.05 (d, J - 2.6 Hz, IH), 7.87 - 7.74 (m,

4H), 7,49 (d, J = 8.8 Hz, IH),

ESIMS m/z 599 7, 15 (ddd, J = 11.2, 8,7, 2.9 Hz,

F1004

([M + HD IH), 7,08 (tt, J = 8.6, 2 ,0 Hz,

IH), 3,68 (d, J = 8.4 Hz, IH), 3.54 (d, J = 8,4 Hz, I H) ; i ⁹ F NMR (376 MHz, Acetone-c e) δ -62.91, - 115.67, -122.06, - 122. 18 *H NMR (400 MHz, Acetone-de) δ

10.19 (s, 1H), 9,43 (s, 1H), 8.68 (q, J = 8.3, 7.5 Hz, 1H), 8.10 (s, 1H), 8.01 (d, J ^~ 2.6 Hz, 1H), 7,83 (dd, J = 8.7, 2,6 Hz, 1H),

ESIMS m/z 680

F1023 7,49 (s, 3H), 7.17 (t, J = 10,4 Hz,

([Μ + ΗΓ)

1H), 3.66 (d, J = 8,3 Hz, 1H), 3.43 (d, J - 8,3 Hz, 1H), 1.50 (s,

9H);

¹⁹ F NMR (376 MHz, Acetone-cfe) δ

-128.34

^X H NMR (400 MHz, Acetone-de) δ 10.21 (s, 1H), 9.47 (s, 1H), 8.20 (tt, J = 9.0, 5,9 Hz, 1H), 8,03 (d, J - 2,6 Hz, 1H), 7,80 (dd, J = 8,8, 2.6 Hz, 1H), 7.58 (s, 1H),

ESIMS m/z 583

F1024 7.51 - 7.42 (rr>, 2H), 7.20 - 7.02

([M + H] ⁺ )

(m, 2H), 3.67 (d, J = 8.3 Hz, 1H),

3.43 (d, J = 8,3 Hz, 1H); 1 ⁹ F NMR (376 MHz, Acetone-ds) δ -111.23, -115.58, -122.01,

-122.13

»H NMR (400 MHz, Acetone-cfe) δ 10.12 (s, 1H), 9,43 (s, 1H), 8.18 (tt, J - 8.9, 5,8 Hz, 1H), 7,89 (d,

J = 2.6 Hz, 1H), 7.71 (dd, J = 8.8, 2.6 Hz, 1H), 7.53 (q, J = 1.5

Hz, 1H), 7.48 - 7,38 (m, 2H),

ESIMS m/z 583

F102S 7.14 (ddd, J ^~ 11,2, 8.7, 2.9 Hz,

([M + H] ⁺ )

1H), 7.06 (tt, J - 8.9, 2.0 Hz,

1H), 3,58 (d, J - 11.3 Hz, 1H), 3,29 (d, J = 11.3 Hz, 1H). ; ⁹ F NMR (376 MHz, Acetone-de) δ -112,52, -115.7.3, -122,08, H NMR (400 MHz, Acetone-de) δ 10,16 (s, 1H), 9,23 (s, 1H), 7,99 (d, J - 2.5 Hz, 1H), 7,81 (dd, J = 8,8, 2.6 Hz, 1H), 7,73 (ddd, J = 9.5, 7.9, 5.7 Hz, 1H), 7.52 - 7.43

ESIMS /z 580

F1026 (rrs, 4H), 6.97 (t, J = 10.7 Hz,

([M + H] ⁺ )

1H), 4.69 (d, J - 9.4 Hz, 2H), 3.66 (d, J - 8.3 Hz, 1H), 3.43 (d,

J - 8.3 Hz, 1H);

1 F NMR (376 MHz, Acetone-ds) δ -137.27, -139.71, -139.73

^! H NMR (400 MHz, DMSG-cfe) δ

11.01 (d, J - 22.2 Hz, 2H), 10,76 (s, IH), 7.92 (cl, J - 2,6 Hz, IH), 7,77 (dd, J - 9.0, 2,5 Hz, 2H),

ESIMS m/z 685 7.69 (d, J = 8.3 Hz, IH), 7.64 -

F1146

172 ([M-cm 7.52 (m, 3H), 7.43 (dd, J = 8.6,

2.1 Hz, IH), 3.60 (d, J = 8,4 Hz, IH), 3.47 (d, J = 8.5 Hz, IH); 1 ^S F NMR (376 MHz, DMSO-de) δ

-117.66

^J H NMR (400 MHz, Acetone-cfe) δ 10.05 (s, IH), 9,32 (s, IH), 8.04 (td, J = 8.9, 6,0 Hz, IH), 7,88 (t, J = 2.5 Hz, 2H), 7.79 (d, J = 2.0 Hz, IH), 7.66 (dd, J - 8.8, 2.6

ESIMS m/z 633 Hz, IH), 7.33 (d, J - 8.7 Hz, IH),

F1147

([M + H] ⁺ ) 7.00 (ddd, J - 11.2, 8.8, 2.8 Hz,

IH), 6.92 (tt, J = 8.8, 2.2 Hz, IH), 3,62 (d, J = 8.3 Hz, IH), 3.38 (d, J = 8.3 Hz, IH); 1 ⁹ F NMR (376 MHz, Acetone-de) δ -63.27, -115.53, -122,00

»H NMR (400 MHz, Acetone-cfe) δ 10.15 (s, IH), 9.42 (s, IH), 8.17 (td, J = 8.9, 6,0 Hz, IH), 8,00 - 7,95 (m, IH), 7.87 (dd, J = 13.9,

2,3 Hz, 2H), 7,71 (dd, J = 8.8,

ESIMS m/z 633

FI14S 2.6 Hz, IH), 7.44 (d, J = 8,8 Hz,

([M + H] ⁺ )

IH), 7.19 - 7.01 (m, 2H), 3.65 (dd, J ^~ 11.2, 1.1 Hz, IH), 3.34

(d, J - 11.2 Hz, IH);

i ⁹ F NMR (376 MHz, Acetone-de) δ -63.24, -115.71, -122.10

^J H NMR (400 MHz, Acetone- a) δ 10.19 (s, IH), 9.27 (s, IH), 8,01 (dd, J = 6.3, 2.3 Hz, 2H), 7,93 (d,

J = 2.0 Hz, IH), 7.80 (dd, J - 8.8, 2.6 Hz, IH), 7.47 (d, J = 8.7

ESIMS m/z 648 Hz, IH), 7,37 (td, J = 8.6, 5.6 Hz,

F1I49

([M + H] ^" ) IH), 6,88 (ddd, J = 10,9, 9,1, 2,0

Hz, IH), 4,77 (s, 2H), 3,77 (d, J

- 8.3 Hz, IH), 3.53 (d, J - 8.3

Hz, IH);

¹⁹ F NMR (376 MHz, Acetone- /&) δ ^l H NMR (400 MHz, Acetone-de) δ

10.14 (s, IH), 9.23 (s, IH), 8.05 - 7.95 (m, IH), 7.89 (d, J - 2.0 Hz, IH), 7.82 (d, J = 2.6 Hz, IH), 7,72 (dd, J = 8.8, 2.6 Hz, IH), 7.43 (d, J = 8.8 Hz, IH), 7.35

ESIMS m/z 648

F1I50 (td, J = 8,6, 5.6 Hz, IH), 6.88

([M + H] ^~ )

(td, J = 9,8, 9,0, 2,1 Hz, IH), 4,75 (d, J = 8.5 Hz, 2H), 3.69 - 3,63 (m, IH), 3.33 (d, J = 11.2

Hz, IH);

¹⁹ F NMR (376 MHz, Acetone-de) δ

-63.23, -137.28, -144.27

÷H NMR (400 Hz, DMSO-de) δ 10.78 (s, IH), 9.94 (d, J = 1.9 Hz, IH), 7.77 (d, J - 5.4 Hz, IH),

HRMS-ESI 7.71 (td, J - 6.8, 2.3 Hz, 2H),

(m/z)[M÷r 7.52 - 7.42 (m, 2H), 6.90 (t, J =

110- caicd for 9.6 Hz, IH), 6.82 (q, J = 8.1, 7,6

F1151

116 C24H16CI3F4N3O2, Hz, IH), 5,29 (s, 2H), 3.57 (d, J

559,0244; found, = 8.4 Hz, IH), 3.41 (d, J = 8,5 559,0245 Hz, IH), 2,38 - 2.23 (m, 3H);

1 ⁹ F NMR (376 MHz, DMSG-de) δ -117.31, -123.71, -134.08, -134.11, -138.53, -138.56 H NMR (400 MHz, DMSO-de) δ 11.14 (s, IH), 10.71 (s, IH), 7.88

HRMS-ESI (dd, J = 11.3, 2,4 Hz, IH), 7,77 - (m/z)[M + ] ⁺ 7,67 (m, 3H), 7,63 (dd, J - 2.3,

248- caicd for 1.2 Hz, IH), 7.47 (dd, J - 8.2,

IF «S 2

251 C23H13CUF3N2O2, 3.2 Hz, 2H), 7.28 - 7.17 (m, 2H),

545,9683; found, 3.60 (d, J = 8.4 Hz, IH), 3.46 (d, 545.9684 J = 8.4 Hz, IH);

1 ⁹ F NMR (376 MHz, DMSO-cfe) δ

^'! H NMR (400 MHz, DMSO-de) δ 11.14 (s, IH), 10,51 (s, IH), 7.89 (dd, J = 11,3, 2,4 Hz, IH), 7,82 -

HRMS-ESI 7,70 (m, 2H), 7,65 (dd, J = 2.5, (m/z)[ + ] ⁺ 1.2 Hz, IH), 7.53 - 7.44 (m, 2H),

236- caicd for 7,39 (ddd, J = 10.9, 9,1, 2,9 Hz,

F1I53

239 C23H12CUF4N2O2, IH), 7.20 - 7.08 (m, IH), 3.60

563.9589; found, (d, J - 8.4 Hz, IH), 3.45 (d, J - 563.9582 8.5 Hz, IH);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -112.64, -112.96, -112.98, -117.23, -117.36, -117.37 ^l H NMR (400 MHz, Acetone-de) δ

10.17 (s, IH), 8.78 (d, J - 6.5

Hz, IH), 7.98 (d, J = 2.6 Hz, IH), 7.80 (dd, J - 8.8, 2.6 Hz, IH), 7.52 - 7.37 (m, 5H), 7.30 (s, 2H), 7,38 - 7.15 (m, 3H), 6.55 (ddt, J = 11.8, 6.3, 3.0 Hz, 2H),

4.89 (s, IH), 3.66 (d, J = 8.3 Hz, IH), 3,47 - 3.33 (m, 3H), 2.92

ESIMS m/z 662 (dd, J = 8,3, 6.5 Hz, 2H), 2.29 (s,

F1I77

([M + H] ^~ ) 3H);

¹³ C NMR (101 MHz', Acetone-ce) δ

164.74, 162.40, 147.23, 140.02, 138.01, 137.84, 137.44, 134.70, 133.87, 130.19, 128.72, 128.32, 128.29, 127.84, 127.21, 126.79,

119.80, 113.90, 110.04, 61,94,' 45,22, 39.20, 37,49, 35.40,

17,84

¹ H NMR (400 MHz, Acetone-ce) δ

10,20 (s, IH), 8,80 (s, IH), 8.13 (s, IH), 7,98 (d, J = 2,6 Hz, IH), 7,79 (dd, J = 8.7, 2,7 Hz, IH), 7,51 - 7.37 (m, 4H), 7,30 (s, 2H), 7.38 - 7,14 (m, 4H), 6,56 - 6.37 (m, 2H), 3.65 (d, J - 8.3 Hz, IH), 3.43 (d, J ^~ 8.3 Hz, IH), 3,29 (dd, J = 7.2, 1.7 Hz, 2H), 3.09 (h, J = 7,0 Hz, IH), 2,27 (s,

ESIMS m/z 676

F1178 3H), 1.33 (d, J = 6.9 Hz, 3H);

([M + H] ^" )

1 ³ C NMR (101 MHz, Acetone-c/e) δ 164.84, 162.43, 161.65, 147,29, 145,36, 137.95, 137.85, 137,75, 137,44, 134,70, 133.87, 130,19, 128,40, 127,84, 127.18, 126,79, 126.74, 126.21, 125.09, 124.91, 121.36, 121.27, 119.81, 119.73, 113.88, 109.99, 61.96, 50.85, 39.18, 39.12, 37.50, 19.03,

17.84

H NMR (400 MHz, Acetone-ce) δ

10,20 (s, IH), 9.53 (s, IH), 9.41 (s, IH), 8.20 - 7.98 (m, 4H),

7.91 - 7,76 (m, 3H), 7,68 - 7,58 (m, IH), 7,63 - 7,34 (m, 5H),

ESIMS m/z 701 7,18 (td, J = 9.2, 2,0 Hz, IH),

FI179

([M + H] ⁺ ) 3.72 (d, J = 8.3 Hz, IH), 3.43 (d,

J = 8.3 Hz, IH).

¹⁹ F NMR (376 MHz, Acetone-ce) δ -61.85, -117.65, -123.13, - 128.69.

^l H NMR (400 MHz, Acetone-de) δ

10.34 (s, IH), 8.61 (d, J - 2.7 Hz, IH), 8.05 - 7.95 (m, 2H), 7.63 (d, J - 8.8 Hz, IH), 7.50 (s, 3H), 7.41 (s, IH), 3.68 (d, J = 8.3 Hz, IH), 3.47 (d, J = 8.3 Hz,

ESIMS m/z 602 IH), 2.59 (s, 3H), 2,35 (s, 3H);

F1230

([M + H] ^~ ) ¹³ C NMR (101 MHz, Acetone-de) δ

163,40, 162.98, 152.99, 147,63, 138,79, 138,03, 135.40, 133,45, 132,55, 130,57, 129.49, 128,64, 128,55, 128,53, 127.96, 126,79, 125,11, 122,98, 62.59, 39.91, 39.87, 38.25, 19.65, 15.79

*H NMR (400 MHz, Acetone-do) δ 10.23 (s, IH), 9.49 (s, IH), 8.91

(s, IH), 8.13 - 7.99 (m, 2H), 7.90 - 7.77 (m, 3H), 7.53 - 7.43

(m, 2H), 7.11 (td, J = 9.3, 2.0

ESIMS m/z 639

F1231 Hz, IH), 3.72 (d, J = 8.3 Hz, IH),

([M + H] )

3.43 (d, J = 8.3 Hz, IH), 2.16 (s,

3H);

i ⁹ F NMR (376 MHz, Acetone-ds) δ -61.88, -117.61, -123,33, - 128,80

*H NMR (400 MHz, Acetone-ds) δ 10,19 (s, IH), 9,46 (s, IH), 8.19 (td, J = 8,9, 5,9 Hz, IH), 8,10 - 7.95 (m, 3H), 7.89 - 7.74 (m, 2H), 7.48 (d, J ^~ 8.7 Hz, IH),

ESIMS m/z 657

F1232 7.21 - 7.02 (m, 2H), 3.81 (d, J =

([M + H] ⁺ )

8.3 Hz, IH), 3.54 (d, J = 8.2 Hz,

IH);

i ⁹ F NMR (376 MHz', Acetone-ds) δ JL ^" * 55 _f -3» ^ ^32 ^ ϊ> 22 _* < ^

122,15

l NMR (400 MHz, Acetone-de) δ 10.14 (s, H), 9,42 (s, IH), 8.17 (td, J = 8,9, 5,9 Hz, IH), 7,95 - 7.83 (m, 3H), 7,78 (s, IH), 7.72 (dd, J - 8,7, 2,6 Hz, IH), 7,44 (d, J - 8.7 Hz, IH), 7.14 (ddd, J -

ESIMS m/z 657

F1233 11.2, 8.8, 2.8 Hz, IH), 7.06 (ddd,

([M + HD

J - 10.6, 8.7, 2.2 Hz, IH), 3.69 (d, J = 11.2 Hz, IH), 3.34 (d, J =

11.2 Hz, IH) _f i ⁹ F NMR (376 MHz, Acetone-ds) δ -115.72, -115.74, -122.07, - 122,21 *H NMR (400 MHz, DMSG-cfe) δ

10.96 (s, 1H), 10.79 (s, 1H), 10.51 (s, 1H), 7.94 (d, J - 2.6 Hz, IH), 7.82 - 7.66 (rr>, 3H), 7.56 (d, J = 8.8 Hz, IH), 7.52 -

ESIMS m/z 642 7.41 (m, 2H), 7.28 (td, J = 9.2,

F1270

([M + H] ^~ ) 1.8 Hz, IH), 6.55 (t, J = 53,2 Hz,

IH), 3.59 (d, J = 8,4 Hz, IH),

3,44 (d, J = 8.5 Hz, IH); 1 ⁹ F NMR (376 MHz, DMSG-cfe) δ -117.28, -120.66 (d, J = 2,6 Hz), -124,22 (d, J = 2,7 Hz), -125,80

*H NMR (400 MHz, DMSO-de) δ rotamers 10,97 (s, IH), 10.64 (s, 0.65H), 10.55 (s, 0.35H), 7.95 (q, J - 4.4, 3.1 Hz, 2H), 7.86 - 7.71 (m, 2H), 7.69 (d, J = 8.4 Hz, IH), 7,56 (d, J = 8.8 Hz, IH), 7.43 (dd, J = 8,4, 2.1 Hz, IH), 7.41 - 7.28 (m, IH), 7.04 (t, J =

ESIMS m/z 672 52.2 Hz, 0.35H), 6.34 (t, J = 51,9

FI271

([M + H] ⁺ ) Hz, 0.65H), 3,65 - 3.55 (m, IH),

3,50 - 3.44 (in, IH), 3.41 (s,

IH), 3,24 (s, 2H);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -122.12 (d, J - 7.3 Hz), -123.13 (cl, J - 3.4 Hz), -124.26 (dq, J - 5.8, 2.8 Hz), -125.56 (d, J = 9.0 Hz), -126.21 (d, J = 3,5 Hz),

-126,48

^"! H NMR (400 MHz, DMSO-de) δ 10,95 (s, IH), 10,05 (d, J = 17.2 Hz, 2H), 8.04 (d, J = 2.6 Hz, IH), 7.80 - 7.72 (m, 2H), 7,70 (d, J = 8.3 Hz, IH), 7.57 (d, J = 8,8 Hz,

ESIMS m/z 692

F1272 3H), 7.43 (dd, J = 8,6, 2.1 Hz,

([M + H] ^"1" )

IH), 7,32 (s, IH), 6.78 (s, IH), 3,61 (d, J = 8.5 Hz, IH), 3.47 (d, J = 8,5 Hz, IH);

¹⁹ F NMR (376 MHz, DMSO-de) δ

^J H NMR (400 MHz, Acetone-do) δ 10.19 (s, IH), 9.48 (s, IH), 9.26 (s, IH), 8.09 (td, J - 8.8, 5.6 Hz,

IH), 8,02 (d, J = 2.6 Hz, IH), 7.87 - 7.77 (m, 3H), 7.48 (dt, J =

9.8, 5.2 Hz, 2H), 7.13 (td, J =

ESIMS m/z 748

FI273 9.3, 1.9 Hz, IH), 3.71 (d, J = 8,3

([M + H] ⁴ )

Hz, IH), 3,43 (d, J = 8.3 Hz, IH), 2.24 (d, J = 7.6 Hz, IH), 1.77 (s,

3H), 1,63 - 1,56 (m, IH); i ⁹ F NMR (376 MHz, Acetone- e) δ -61.85, -117.58, -122.69, - ^X H NMR (400 MHz, Acetone-de) δ

10.23 (s, 1H), 9.26 (s, 1H), 8.30 - 8,12 (m, 2H), 8.00 (d, J - 2.6 Hz, 1H), 7.82 (ddd, J - 16.9, 7.7, 2.5 Hz, 3H), 7.68 (d, J = 8.4 Hz,

2H), 7.48 (t, J = 10.1 Hz, 3H),

ESIMS m/z 732

F1296 6.90 (ddd, J = 11,5, 9.1, 2,1 Hz,

([M + H] ^~ )

IH), 5.56 (s, IH), 4.71 (d, J = 7.3 Hz, 2H), 3.71 (d, J = 8,3 Hz,

IH), 3.45 (d, J = 8,3 Hz, IH); i ⁹ F INiMR (376 MHz, Acetone-de) δ -61.89, -117.64, -133,36, - 140,76

^X H NMR (400 MHz, Acetone-de) δ 10,22 (s, IH), 9.48 (s, IH), 8.89

(s, IH), 8.09 - 7.97 (m, 2H), 7.81 (ddd, J - 11.5, 7.3, 2.4 Hz, 3H), 7.47 (t, J = 9.3 Hz, 2H), 7.08 (td, J = 9.2, 1,9 Hz, IH),

ESIMS m/z 705 5.69 (s, IH), 3.71 (d, J = 8.3 Hz,

FI297

([M + H] ) IH), 3,41 (d, J = 8.3 Hz, IH),

2.83 - 2.70 (m, IH), 2,41 - 2,17 (m, 2H), 2.19 - 1,94 (m, 4H), 1.81 - 1.65 (rrs, IH);

i ⁹ F NMR (376 MHz, Acetone-de) δ -61.82, -117.52, -123.10, - 128.61

*H NMR (400 MHz, Acetone-de) δ

10.22 (s, IH), 9.90 (s, IH), 9.60 (s, IH), 8.28 - 8.14 (m, 3H),

8.06 (d, J ^~ 2.7 Hz, IH), 7.87 - 7.77 (m, 3H), 7.80 - 7,71 (rrs, IH), 7,66 - 7,56 (m, 2H), 7.47

ESIMS m/z 729

F1298 (dd, J = 11.0, 8,4 Hz, 2H), 7.23

(f + H] ⁺ )

(td, J - 9,2, 1.9 Hz, IH), 3.72 (d,

J = 8.3 Hz, IH), 3.44 (d, J = 8.3

Hz, IH);

¹⁹ F NMR (376 MHz, Acetone-de) δ -61.83, -117.52, -122,50, - 128,11

^J H NMR (400 MHz, Acetone-de) δ 10,20 (s, IH), 9.52 (s, IH), 9.40 (s, IH), 8.11 (tcl, J - 8.7, 5.5 Hz,

IH), 8,03 (d, J - 2.6 Hz, IH), 7.87 - 7,78 (m, 3H), 7,48 (dd, J

ESIMS m/z 717 = 8,7, 3.4 Hz, 2H), 7.15 (td, J =

F1299

(ΓΜ + Η] ⁺ ) 9,2, 1.9 Hz, IH), 4.35 (s, 2H),

3.75 - 3.68 (m, IH), 3,43 (d, J =

8.3 Hz, IH), 3.18 (s, 3H); i ⁹ F NMR (376 MHz, Acetone-de) δ *H NMR (400 MHz, Acetone-c/e) δ

10.22 (s, 1H), 9.56 (s, 1H), 9.35 (s, 1H), 8.13 (td, J = 8.8, 5.6 Hz,

1H), 8.02 (d, 3 ^~ 2.6 Hz, IH), 7.87 - 7.76 (m, 4H), 7.47 (dt, 3 = 8.4, 5.1 Hz, 2H), 7.32 - 7.20 (m,

ESIMS m/z 691

F1300 IH), 7,25 - 7,11 (m, IH), 6.65

([M + H] ⁴ )

(ddd, 3 = 20.0, 3.5, 1.8 Hz, H), 3.71 (d, 3 = 8,3 Hz, IH), 3,43 (d,

J -- ^■ 8.3 Hz, IH);

! ⁹ F NMR (376 MHz, Acetone-c/e) δ -61.83, -117.53, -122,76, - 128,41

^J H NMR (400 MHz, Acetone-c/e) δ

10.24 (d, 3 = 13.2 Hz, 2H), 9.60 (s, IH), 8.20 (td, J - 8.8, 5.7 Hz, IH), 8.03 (dd, 3 ^~ 14.9, 2.6 Hz, IH), 7.91 - 7.75 (m, 3H), 7,47 (txl, J = 8.7, 1,7 Hz, 2H), 7,23

ESIMS m/z 724

FI301 (to, J = 9,3, 2,0 Hz, IH), 6.65 (tt,

([M + H] ⁴ )

3 = 52.1, 5.4 Hz, IH), 3,72 (d, 3 = 8.4 Hz, IH), 3.43 (d, 3 = 8.3

Hz, IH);

i ⁹ F NMR (376 MHz, Acetone-ce) δ -61.85, -117.50, -123.15, -125,60, -128.43, -140.20

*H NMR (400 MHz, Acetone-c/e) δ 10.21 (s, IH), 9,53 (s, IH), 9.29 (s, IH), 8.10 (td, J = 8.8, 5.6 Hz,

IH), 8.02 (d, J ^~ 2.6 Hz, IH), 7.87 - 7.76 (m, 4H), 7.48 (dt, 3 -

10.1, 5.2 Hz, 2H), 7.15 (td, J =

ESIMS m/z 721

F1302 9,2, 2,0 Hz, IH), 6.94 - 6.87 (m,

([M + H] ⁴ )

IH), 3.71 (d, 3 - 8,3 Hz, IH), 3.43 (d, J - 8.3 Hz, IH), 2,54 (d,

J - 1.1 Hz, 3H);

! ⁹ F NMR (376 MHz, Acetone-c/e) δ -61.86, -117.62, -122,97, - 128,51

*H NMR (400 MHz, Acetone-c/e) δ 10,22 (s, IH), 9.53 (s, IH), 9.25

(s, IH), 8.11 - 8.00 (m, 2H), 7.87 - 7,75 (m, 3H), 7.47 (dt, J -

8.4, 5.1 Hz, 2H), 7.12 (td, J -

ESIMS m/z 693 9.2, 1.9 Hz, IH), 3.71 (d, J = 8.3

F1303

([M + H] ⁴ ) Hz, IH), 3.58 (td, 3 = 8.4, 4.3 Hz,

H), 3,42 (d, 3 = 8.3 Hz, IH), 3.43 - 3.26 (m, 4H);

i ⁹ F NMR (376 MHz, Acetone-c/e) δ -61.81, -117,51, -12j,0b, - 128.51 *H NMR (400 MHz, Acetone-de) δ

10.40 (s, IH), 10.21 (s, IH), 9.61 (s, IH), 8.21 (td, J = 8.8, 5.6 Hz, IH), 8.04 (d, J ^~ 2.6 Hz, IH), 7,80 (dd, J = 8.8, 2,6 Hz, IH),

ESIMS m/z 694 7.64 (d, J = 6,3 Hz, 2H), 7.49 (d,

F1332

([M + H] ^" ) J = 8.8 Hz, IH), 7.25 (td, J = 9.3,

2,0 Hz, IH), 3,65 (d, J = 8,3 Hz,

IH), 3.42 (d, J = 8,3 Hz, IH); 1 ⁹ F NMR (376 MHz, Acetone-de) δ -75.82, -118,89, -123,31, - 128,50

*H NMR (400 MHz, CDCb) δ 9,09 (s, IH), 8.55 (s, IH), 8,15 (td, J - 8.8, 5.7 Hz, IH), 8.04 (s, IH), 7.82 (dd, J ^~ 10.4, 2.5 Hz, IH), 7.42 (d, J ^~ 2.0 Hz, IH), 7.34 (t,

J = 1.9 Hz, IH), 7.15 (dd, J =

ESIMS m/z 674

F1333 1.9, 0.7 Hz, 2H), 7.02 (t, J = 9.0

([M-H]-)

Hz, IH), 6.16 (t, J = 53.8 Hz, IH), 3,53 (d, J = 8.1 Hz, IH),

2.87 (d, J = 8,2 Hz, IH); i ⁹ F NMR (376 MHz, CDCb) δ -108.67, -121.24, -125.66,- 128.24

^X H NMR (400 MHz, CDCb) δ 8.40 - 8.26 (m, 3H), 7.94 (d, J = 10.4 Hz, IH), 7,76 (bs, IH), 7,61 (s, IH), 7.32 (s, 2H), 7.10 (t, J - 9.0

ESIMS m/z 726

F1334 Hz, IH), 3.55 (d, J = 7.9 Hz, IH),

([M-H] ^" )

2.81 (d, J - 8.0 Hz, IH); 1 ⁹ F NMR (376 MHz, CDCb) δ -74.98, -108.36, -121.81, - 129,55

*H NMR (400 MHz, CDCb) δ 8,66 (s, IH), 8.42 (s, IH), 8,33 - 8.23 (m, IH), 7,88 (dd, J = 10,3, 2,5 Hz, IH), 7,81 (s, IH), 7.55 (s, IH), 7.31 (d, J = 0,7 Hz, 2H),

ESIMS m/z 708

F133S 7,06 (t, J = 9.0 Hz, IH), 6.15 (t, J

([M-H] ^" )

= 53.8 Hz, IH), 3.53 (d, J = 8.0 Hz, IH), 2.83 (cl, 3 - 8.1 Hz, IH); i ⁹ F NMR (376 MHz, CDCb) δ -108.53. -121.83. -125.58,

-129.09 ^l H NMR (400 MHz, Acetone-c/e) δ

10.44 (s, IH), 9.31 (s, IH), 7.94 (dd, J = 11.2, 2.4 Hz, IH), 7.76 - 7.66 (m, 2H), 7.51 (s, 3H), 6.99 (t, J = 10,7 Hz, IH), 4.71 (bs,

ESIMS /z 598 2H), 3.67 (d, J = 8.3 Hz, IH),

F1336

([M + H] ⁺ ) 3.48 (dd, J = 8,3, 2.0 Hz, IH);

i ⁹ F NMR (376 MHz, Acetone-ce) δ -113.74, -113,76, -137,08, -137.11, -139.74, -139.76, -139.77, -139.86, -139.89,

-139.90

*H NMR (400 MHz, CDCb) δ 8,64 (s, IH), 8.15 (s, IH), 8.02 (dd, J - 10.4, 2.6 Hz, IH), 7.88 (dd, J = 9.2, 7.7 Hz, IH), 7.57 (dd, J -

ESIMS m/z 632 2.5, 1.4 Hz, IH), 7.30 (s, 2H),

F1337

([M + H] ⁺ ) 6.87 (t, J = 10.3 Hz, IH), 3.71 (s,

2H), 3,53 (d, J = 8.1 Hz, IH),

2.82 (d, J = 8,1 Hz, IH); i ⁹ F NMR (376 MHz, CDCb) δ -108.49, -134.30, -139.55

*H NMR (400 MHz, acetone-cfe) δ 10,33 (s, IH), 9.31 (s, IH), 7.93 (dd, J = 11,3, 2.4 Hz, IH), 7.76 - 7.60 (m, 4H), 7.46 (ddd, J = 8.3,

ESIMS m/z 598 2.1, 0,7 Hz, IH), 6.99 (t, J = 10.7

FI33S

([M + H] ⁺ ) Hz, IH), 4,72 (ad, J = 9,3 Hz,

2H), 3.65 (d, J ^~ 8.3 Hz, IH),

3.40 (d, J - 8.3 Hz, IH); 1 ⁹ F NMR (376 MHz, CDCb) δ

^V H NMR (400 MHz, acetone-c/e) δ 10.35 (s, IH), 9.31 (s, IH), 7.93 (dd, J = 11.3, 2.4 Hz, IH), 7.84 (dd, J = 7.0, 3,9 Hz, 2H), 7,75 - 7.66 (m, 2H), 7,49 (t, J = 9.9 Hz,

IH), 6.99 (t, J = 10,7 Hz, IH),

ESIMS m/z 615

F1339 4.72 (d, J = 9.4 Hz, 2H), 3.73 (d,

([M + H] ^" )

J = 8.2 Hz, IH), 3.45 (d, J = 8,3

Hz, IH);

1 ⁹ F NMR (376 MHz, CDCb) δ - 61.45 (d, J - 12.8 Hz), -108.53, - 114.43 (q, J - 12.7 Hz), -134.40,

-139.61

Ή NMR (400 MHz, acetone-ce) δ 10.48 (s, IH), 10.26 (br s, IH),

9.68 (s, IH), 8,53 (td, J = 8,0, 5,0 Hz, IH), 7,95 (dd, J = 11.2,

2.5 Hz, IH), 7.74 (dd, J = 2,4,

ESIMS m/z 694

FI340 1,4 Hz, IH), 7,51 (d, J = 0.7 Hz,

([M + H] ⁺ )

3H), 7,36 (t, J = 10.3 Hz, IH),

3.67 (d, J = 8,3 Hz, IH), 3,48 (dd, J = 8.3, 1.2 Hz, IH);

¹⁹ F NMR (376 MHz, CDCb) δ - 75.53, -108.40, -125.82, -127.37

NMR (400 MHz, acetone-cfc) δ

10.17 (s, IH), 9.75 (s, IH), 9.55 (s, IH), 8.18 (tt, J ^~ 8.6, 4.3 Hz,

IH), 8.04 (d, J ^~ 2.6 Hz, IH), 7.88 - 7.74 (m, 2H), 7.62 (d, J =

ESIMS m/z 703 8.3 Hz, IH), 7.57 - 7.41 (m, 2H),

F1359

([M + H] ^~ ) 7.21 (td, J = 9.2, 2.0 Hz, IH),

6,45 (t, J = 53,5 Hz, IH), 3,64 (d, J = 8.3 Hz, IH), 3.38 (d, J =

8.3 Hz, IH);

1 ⁹ F NMR (376 MHz, acetone-cfc) δ -123.19, -127.10, -128.50

(thin film)

3276,

1659,

1588, ^l H NMR (400 MHz, DMSO-de) δ 1569, 10.99 (s, IH), 10.58 (s, IH), 7.88 1534, (d, J = 2.6 Hz, IH), 7.74 (dd, J =

ESIMS m/z 611

F1360 1488, 8.8, 2.6 Hz, IH), 7.70 (s, 2H),

([M + HD

1404, 7.63 (t, J = 2.0 Hz, IH), 7.58 -

■L 2 _f 7,53 (m, 3H), 3,62 (d, J = 8.4 Hz,

1220, H), 3,53 (d, J = 8.5 Hz, IH) 1189,

1047, 798,

709

*Η NMR (400 MHz, acetone-cfc) δ 10,21 (s, IH), 9,57 (s, IH), 8.68 (s, IH), 8.18 (tt, J = 8.7, 5.6 Hz,

IH), 8.04 (d, J ^~ 2.5 Hz, IH), 7.88 - 7.78 (m, 3H), 7.48 (t, J = 9.0 Hz, 2H), 7.21 (td, J - 9.3, 2.1 Hz, IH), 3.82 (dd, J = 14.5, 5.9

ESIMS m/z 784 Hz, IH), 3.72 (d, J = 8.3 Hz, IH),

F1361

([M + H] ^~ ) 3,44 (d, J = 8,3 Hz, IH), 3,30

(dd, J = 14,5, 8.3 Hz, IH), 2.23 (dtd, J = 10.6, 8.1, 5.9 Hz, IH), 1,93 (dd, J = 10.6, 7,7 Hz, IH),

1,65 (t, J = 7.8 Hz, IH); 1 ⁹ F NMR (376 MHz, acetone-cfc) δ -61.88, -117.60, -123.18, -128.63

^X H NMR (400 MHz, acetone-do) δ 10.21 (s, IH), 9.49 (s, IH), 9.10

(s, IH), 8.07 - 7.88 (m, 2H), 7.88 - 7.72 (m, 3H), 7.58 - 7.38

(m, 2H), 7.07 (td, J = 9.2, 1.9 Hz, IH), 3.70 (d, J = 8.2 Hz, IH),

ESIMS m/z 679 3.39 (d, J = 8.3 Hz, IH), 1.65

FI362

([M + H] ⁺ ) (dt, J = 8,5, 4.2 Hz, IH), 1.42 -

1,25 (m, IH), 1,25 - 1,00 (m, 4H), 0,68 (ddd, J = 8,0, 6,2, 3,6

Hz, IH);

¹⁹ F NMR (376 MHz, acetone-do) δ -61.81, -117.48, -122.94, -128.48 NMR (400 MHz, acetone-de) δ

10.20 (s, 1H), 9,52 (s, 1H), 8.92 (s, 1H), 8.07 (td, J = 8.8, 5.6 Hz,

IN), 8.01 (d, J - 2,6 Hz, 1H), 7.86 - 7,75 (m, 3H), 7,47 (t, J =

ESIMS m/z 683 8.9 Hz, 2H), 7.11 (td, J = 9,2, 1.9

F1363

([M + H]*) Hz, 1H), 4,13 (s, 2H), 3.74 - 3.63

(m, 3H), 3,42 (d, J = 8.3 Hz, 1H),

1.24 (t, J = 7.0 Hz, 3H); 1 ⁹ F NMR (376 MHz, acetone-de) δ -61.81, -117.48, -122,89, - 128,53

lH NMR (400 MHz, acetone-de) δ 10,20 (s, 1H), 9.48 (s, 1H), 8.91 (s, 1H), 8.07 (td, J - 8.8, 5.6 Hz,

1H), 8.01 (d, J - 2.6 Hz, 1H), 7.87 - 7,76 (m, 3H), 7,52 - 7.43

(m, 2H), 7,11 (td, J = 9,2, 1.9

ESIMS m/z 697

F1364 Hz, 1H), 4,04 (q, J = 6.7 Hz, 1H),

([M + H] j

3.76 - 3,57 (m, 3H), 3.42 (d, J = 8,3 Hz, 1H), 1.42 (d, J = 6.7 Hz,

3H), 1.25 (t, J - 7.0 Hz, 3H); 1 ⁹ F NMR (376 MHz, acetone-de) δ -61.83, -117.51, -123.18, -128.81

*H NMR (400 MHz, acetone-de) δ 10,19 (s, 1H), 9.52 (s, 1H), 7.94 (d, J = 2,7 Hz, 1H), 7,76 (dd, J = 8.8, 2.6 Hz, 1H), 7.61 - 7,48 (m, 2H), 7.46 - 7,36 (m, 2H), 7,32 (t,

ESIMS m/z 562

F136S J - 8.8 Hz, 1H), 7.17 (d, J = 8.6

C[M + H] ⁺ )

Hz, 1H), 6.98 (dd, J = 8,6, 2.4 Hz, 1H), 5,01 (s, 2H), 3,65 - 3.58 (in, 1H), 3.33 (d, J = 8,3 Hz, 1H); 1 ⁹ F NMR (376 MHz, acetone-de) δ

-117.92

νβ NMR (400 Hz, acetone-de) δ 10.19 (s, 1H), 9.98 (s, 1H), 9.88 (s, 1H), 8,28 (d, J - 2,6 Hz, 1H), 8.01 (d, J ------ 2.6 Hz, 1H), 7.81

(ddd, J = 13.7, 8.8, 2.6 Hz, 2H),

ESIMS m/z 658

F1366 7.64 - 7.52 (m, 2H), 7,51 - 7.41

([M + H] ⁺ )

(m, 2H), 7,35 (t, J - 8,9 Hz, 1H),

3.65 - 3.58 (m, 1H), 3.35 (d, J ^~

8.3 Hz, 1H);

1 ⁹ F NMR (376 MHz, acetone-d ₆ ) δ -76.16, -118.19

*H NMR (400 MHz, DMSO-de) δ

11.38 (s, IH), 11.15 (s, IH), 10.67 (s, IH), 7.96 (t, J - 8.0 Hz, IH), 7.90 (dd, J = 11.3, 2.4 Hz,

H RMS- ESI ( /z) IH), 7.77 (d, J = 2,1 Hz, IH), [M + ] ⁺ caicd for 7,70 (d, J = 8,3 Hz, IH), 7,67

100-

F1403 CzsHizCisFeNsOs, (dd, J = 2.4, 1.2 Hz, IH), 7.62 (t,

105

690.9225; found, J = 10.3 Hz, IH), 7.48 - 7,41 (m, 690.9221 IH), 3.63 (d, J = 8,5 Hz, IH),

3.49 (d, J = 8.5 Hz, IH); 1 ⁹ F NMR (376 MHz, DMSO-de) δ -73.88, -112.62, -118,59, -118.61, -118.97, -118.99

÷H NMR (400 MHz, DMSO-de) δ 11.13 (s, IH), 10.74 (s, IH), 10.62 (s, IH), 8.09 (t, J - 8.1 Hz, IH), 7.90 (dd, J - 11.3, 2.4 Hz,

H RMS- ESI (m/z)

IH), 7.82 (s, 2H), 7.66 (dd, J = [M + ] ⁺ caicd for

112- 2.4, 1.2 Hz, IH), 7,57 (t, J = 10,3

F1404 C25H12CI6F5N3O3,

117 Hz, IH), 6,48 (t, J = 53.5 Hz,

706,8930; found,

IH), 3,66 (d, J = 8.4 Hz, IH), 706,8922

3.57 (d, J = 8,4 Hz, IH); 1 ⁹ F NMR (376 MHz, DMSO-de) δ -112.59, -120.01, -120.02, -120.54, -120.55, -125.68 H NMR (400 MHz, DMSO-de) δ 11.38 (s, IH), 11.14 (s, IH), 10.67 (s, IH), 7.96 (t, J = 8.0 Hz,

H RMS- ESI (m/z)

IH), 7.90 (dd, J - 11.3, 2.4 Hz, [M + ] ⁺ caicd for

126- IH), 7.82 (s, 2H), 7.71 - 7.57 (m,

F140S CzsH CieFeNsOs,

131 2H), 3.66 (d, J - 8.4 Hz, IH),

724,8836; found,

3,57 (d, J = 8.5 Hz, IH); 724.8828

1 ⁹ F NMR (376 MHz, DMSO-cfc) δ -73.89, -112.61, -118.59, -118.61, -118.97, -118.99

^' Ή NMR (400 MHz, DMSO-de) δ 11.16 (s, IH), 10,74 (s, IH), 10,62 (s, IH), 8,09 (t, J = 8.1 Hz,

IH), 7.96 - 7.79 (m, 3H), 7,66

H RMS- ESI (m/z) (dd, J = 2,4, 1.2 Hz, IH), 7,59 (q, [M + ] ⁺ caicd for J = 10.2 Hz, 2H), 6.48 (t, J =

98-

F1406 C HuCioFy iO:;, 53.5 Hz, IH), 3.72 (cl, J - 8.4 Hz,

103

690.9879; found, IH), 3.53 (d, J - 8.5 Hz, IH);

690.9874 ¹⁹ F NMR (376 MHz, DMSO-de) δ

-59,90, -112,60, -116,83, -116.87, -116.90, -116.93, -120.01, -120.02, -120.54, NMR (400 MHz, acetone-cfe) δ

10.05 (s, IH), 9.14 (s, IH), 7.81 - 7.71 (m, 3H), 7.70 (s, 2H), 6.96 (t, J - 10.7 Hz, IH), 4.67 (ad, J = 9,4 Hz, 2H), 3,65 (d, J =

ESIMS m/z 628 8.3 Hz, IH), 3.43 (d, J = 8,3 Hz,

F1427

ί[Μ + ΗΓ) IH), 2.40 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone) δ -137,48, -137,49, -137,52, -137.53, -139,86, -139.88, -139.89, -139.98, -140.00,

-140.02

lH NMR (400 MHz, acetone-de) δ 10,07 (s, IH), 9.16 (s, IH), 7.83 (d, J - 6.7 Hz, 2H), 7.80 - 7.67 (m, 3H), 7.48 (t, J - 9.9 Hz, IH),

6.96 (t, J - 10.7 Hz, IH), 4.67

ESIMS m/z 611 (ad, J = 9.3 Hz, 2H), 3.71 (d, J =

FI428

([M + H] j 8.5 Hz, IH), 3.42 (d, J = 8.3 Hz,

IH), 2,40 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone-de) δ -61.88 (d, J = 12,7 Hz), -117,65 (q, J ~ 12.8 Hz), -137.46 (d, J = 3.3 Hz), -139.85 (d, J = 5.2 Hz)

*H NMR (400 MHz, acetone-de) δ 10.12 (s, IH), 9.68 (s, IH), 9.48

(s, IH), 8.71 - 8,63 (m, IH), 7,82 (d, J ------ 2.6 Hz, IH), 7.77 id,

J - 2,5 Hz, IH), 7.67 (d, J - 2.1 Hz, IH), 7.62 (d, J - 8.4 Hz, IH),

ESIMS m/z 672 7.44 (dd, J - 8.4, 2.1 Hz, IH),

F1429

C[M + H] ⁺ ) 7,29 (t, J = 10.3 Hz, IH), 6.41 (t,

J = 53,7 Hz, IH), 3,63 (d, J = 8.3 Hz, IH), 3.38 (d, J = 8.3 Hz, IH),

2,41 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone) δ -124.63, -124.68, -124.70, -124.81, -124.82, -127.22

^L H NMR (400 MHz, acetone-do) δ 10,17 (brs, 2H), 9.54 (s, IH), 8,54 (td, J = 8.1, 5.0 Hz, IH), 7.84 (d, J " 2.6 Hz, IH), 7.77 (d, J - 2.5 Hz, IH), 7.67 (d, J - 2.1 Hz, IH), 7.62 (d, J - 8.3 Hz, IH),

ESIMS m/ 690 7.44 (dd, J = 8,3, 2.2 Hz, IH),

F1430

([M + H] ⁴ ) 7.33 (t, J = 10.2 Hz, IH), 3.62

(d, J = 8,3 Hz, IH), 3,40 (d, J =

8.3 Hz, IH), 2.41 (s, 3H); 1 ⁹ F NMR (376 MHz, ace.tone.-d6) δ -76,03, -122,71, -122,72, -122.73, -122.74, -123.49, -123.50, -123.61, -123.62 ^v ri NMR (300 MHz, DMSO-c/e) rotamers δ 10,94 (s, 1H), 10,65 (s, 0.7H), 10.56 (s, 0.3H), 8.02 - 7,90 (m, 1.7H), 7.87 - 7.78 (m, 0.3H), 7.74 (dt, J = 8.8, 2.9 Hz,

1H), 7,63 (t, J = 1.9 Hz, 1H), 7,60 - 7.53 (m, 3H), 7.44 - 7,27

(m, 1H), 7,04 (t, J = 52.2 Hz,

ESIMS m/z 670 0.3H), 6.35 (t, J = 52.0 Hz,

F1462

([M + H]-) 0.7H), 3,62 (d, J = 8.5 Hz, 1H),

3.52 (d, J = 8,5 Hz, 1H), 3,41 (s, 1H), 3.24 (s, 2H);

¹⁹ F NMR (376 MHz, DMSO-c/e) rotamers δ -122.12 (d, J ^~ 7,1

Hz), -123.13 (d, J - 3.4 Hz), -124,26 (dt, J = 24.2, 6,1 Hz), -125.56 (d, J = 9.5 Hz), -126.21,

-126.49 (dd, J = 6,7, 3.2 Hz) H NMR (300 MHz, DMSO-c/e) δ 11,60 (s, 1H), 10.96 (s, 1H),

10.57 (s, 1H), 7.94 (d, J = 2.6

Hz, 1H), 7.76 (td, J = 5.2, 4.6, 2,7 Hz, 3H), 7,70 (d, J = 8.4 Hz,

ESIMS m/z 774 1H), 7,57 (d, J = 8.8 Hz, 1H),

FI463

([M + H] ^" ) 7,48 - 7.40 (m, 1H), 7,33 (t, J =

9.2 Hz, 1H), 3.61 (d, J - 8.5 Hz,

1H), 3.47 (d, J = 8.5 Hz, 1H);

¹⁹ F NMR (376 MHz, DMSO-c/e) δ

-80.07 (t, J = 8.2 Hz), -119.32,

^"! H NMR (400 MHz, DMSO-ce) δ 10.73 (s, 2H), 8.11 (t, J = 8.5 Hz, 1H), 7,84 (td, J = 8.9, 6.1 Hz,

H RMS- ESI (m/z) 1H), 7.68 (dd, J = 7,0, 2.2 Hz, [M + H] calcd for 1H), 7.55 - 7.34 (m, 4H), 7,16

98- iF X ^^^" C23Hl ₂ Ci4F4N ₂ 02, (td, J = 8.4, 4,7 Hz, 1H), 3,66 (d,

103

563,9589; found, J = 8.6 Hz, 1H), 3.60 (d, J = 8,5 563,9584 Hz, 1H);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -113.01, -113.03, -117.27, -117.96, -117.97, -124.77

*H NMR (400 MHz, DMSO-c/e) δ 10.91 (s, 1H), 10.73 (s, 1H), 8.10

H RMS- ESI (m/z) (t, J - 8.6 Hz, 1H), 7.78 - 7.63 [M + ] ⁺ caicd for (m, 3H), 7.55 - 7.38 (m, 3H),

107-

F1465 C23H13CI4F3N2O2, 7.23 (t, J = 8.8 Hz, 2H), 3.65 (d,

111

545,9683; found, J = 8.6 Hz, 1H), 3.59 (d, J = 8.5 545,9683 Hz, 1H);

1 ⁹ F NMR (376 MHz, DMSO-ce) δ -117.26, -117.95, -124.89 NMR (400 MHz, acetone-cfe) δ

10.08 (s, IH), 9.18 (s, 1H), 7.86 - 7.81 (m, 2H), 7.82 - 7.69 (m, 3H), 7.49 (t, J = 9.9 Hz, IH), 6.97 (t, J = 10.7 Hz, IH), 4.69 (ad, J = 9,4 Hz, 2H), 3,71 (d, J =

ESIMS m/z 610 8.3 Hz, IH), 3.42 (d, J = 8,3 Hz,

F1478

([M + H] ^~ ) IH), 2,40 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61,88 (d, J = 12.9 Hz), -117,66 (q, J = 12.8 Hz), -137,47, -137.50, -139.86, -139.88, -139.89, -139.98, -140.01,

-140.02

^X H NMR (400 MHz, acetone-cfe) δ 10.20 (s, IH), 9.51 (s, IH), 9.24 (s, IH), 8.09 (tcl, J - 8.8, 5.6 Hz, IH), 8,03 (d, J = 2.6 Hz, IH), 7.82 (td, J = 8.8, 2,7 Hz, 3H), 7.47 (dt, J = 8.2, 5.0 Hz, 2H),

ESIMS m/z 732

FI479 7,13 (td, J = 9.3, 2,0 Hz, IH),

([M + H] ⁴ )

4,83 (q, J = 6.8 Hz, IH), 3.71 (d, J = 8.3 Hz, IH), 3.43 (d, J = 8,3 Hz, IH), 1,86 (d, J = 6.8 Hz, 3H); 1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61.82, -117.52, -123.04, -128.46

*H NMR (400 MHz, acetone-cfe) δ 10.20 (s, IH), 9.48 (s, IH), 8.98 (s, IH), 8.10 - 7.99 (m, 2H), 7.81 (ddt, J ^~ 8.8, 6.2, 2.7 Hz, 3H), 7,47 (dt, J = 8.1, 5,1 Hz, 2H), 7,11 (td, J = 9.3, 2,0 Hz,

ESIMS m/z 695

F1480 IH), 4,02 (t, J = 8.2 Hz, IH),

([M + H] ⁴ )

3.94 - 3.65 (m, 4H), 3,42 (d, J = 8.3 Hz, IH), 3.35 (D, J = 7,7 Hz,

IH), 2.29 - 2.11 (m, 2H); 1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61.84, -117.58, -123,27, -128.69

NMR (400 MHz, acetone-cfe) δ

10.22 (s, IH), 9.79 (br s, IH), 9.52 (s, IH), 8.19 (ddd, J - 8.9, 5.7, 3.2 Hz, IH), 7.85 (d, J = 2.5 Hz, IH), 7.77 (d, J = 2.6 Hz, IH), 7.68 (d, J = 2.1 Hz, IH), 7.63 (d, J = 8,4 Hz, IH), 7,45 (ddd, J =

ESIMS m/z 670

F1484 8.4, 2,2, 0.7 Hz, IH), 7.20 (td, J

([M + HD

= 9,3, 2.0 Hz, IH), 6.46 (t, J = 53.5 Hz, IH), 3.62 (d, J = 8,3 Hz, IH), 3,41 (dd, J = 8.3, 1.2 Hz,

IH), 2,41 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone) δ -123.33, -123.38, -127.08, -127.15, -128.62, -128.74

^X H NMR (400 MHz, acetone-a%) δ 10.28 (s, IH), 9.53 (s, IH), 8.24 - 8.09 (m, 2H), 7.85 (d, J = 2.5 Hz, IH), 7,76 (d, J = 2.1 Hz, IH), 7,67 (d, J = 2.1 Hz, IH), 7.63 (d, J = 8,3 Hz, IH), 7,44 (dd, J =

ESIMS m/z 688

FI485 8,4, 2.1 Hz, IH), 7.21 (td, J =

([M + H] ⁺ )

9.2, 1.8 Hz, IH), 3.62 (d, J = 8,3 Hz, IH), 3.42 (d, J = 8.4 Hz, IH),

2.40 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone-do) δ -75.33, -75.64, -76.01, -123.74, -123.79, -128.88, -129.00

^V H NMR (400 MHz, acetone-c/e) δ

10.19 (s, IH), 9.78 (br s, IH), 9.52 (s, IH), 8.19 (ddd, J - 14.4, 8.9, 5.5 Hz, IH), 7.84 (d, J = 2.5 Hz, IH), 7.76 (d, J = 2.6 Hz, IH),

7.71 (s, 2H), 7.20 (td, J = 9.3,

ESIMS m/z 704

F1486 2.1 Hz, IH), 6.46 (t, J = 53,5 Hz,

([M + HD

IH), 3.65 (d, J = 8,3 Hz, IH), 3,47 (dd, J = 8.3, 1.0 Hz, IH),

2.41 (s, 3H);

1 ⁹ F NMR (376 MHz, acetone) δ -123.31, -123.36, -127.08, -127.15, -128.62, -128.73

^X H NMR (400 MHz, acetone-c ₆ ) δ 10.33 (s, IH), 9.53 (s, IH), 8.22 - 8.11 (m, 2H), 7.85 (d, J - 2.5 Hz, IH), 7,76 (d, J = 2.0 Hz, IH),

7.71 (s, 2H), 7,21 (td, J = 9.0,

ESIMS m/z 722

F14S7 1.4 Hz, IH), 3,65 (d, J = 8.4 Hz,

([M + H] ⁴ )

IH), 3,51 (d, J = 8.5 Hz, IH), 2.40 (s, 3H);

¹⁹ F NMR (376 MHz, acetone) δ -75.34, -75.62, -76.00, -123.76, -123.81, -128.88, -129.01 H NMR (400 MHz, acetone-cfe) δ

10.21 (s, IH), 9.78 (s, IH), 9.57 (s, IH), 8.17 (td, J = 8.8, 5.6 Hz, IH), 8.04 (d, J ^~ 2.7 Hz, IH), 7,81 (dd, J = 8.8, 2.6 Hz, IH),

ESIMS /z 607 7.51 - 7,37 (m, 3H), 7.28 - 7.09

F1598

([M + H] ⁺ ) im, 3H), 6,46 (t, J = 53.5 Hz,

IH), 3.59 (d, J = 8,0 Hz, IH), 3,29 (d, J = 8.3 Hz, IH); 1 ⁹ F NMR (376 MHz, acetone-cfc) δ -115.65, -123.06, -127.05,

-128.40

H NMR (400 MHz, acetone-ife) δ 10,20 (s, IH), 9,77 (s, IH), 9.57 (s, IH), 8.16 (td, J - 8.8, 5.6 Hz, IH), 8.04 (d, J - 2.6 Hz, IH), 7.80 (dd, J ^~ 8.8, 2.6 Hz, IH),

ESIMS m/z 624

F1599 7.44 (s, 5H), 7.20 (td, J = 9.2,

([M + H] ⁺ )

2.0 Hz, IH), 6,46 (t, J = 53.5 Hz, IH), 3,60 (d, J = 8.4 Hz, IH), 3.30 (d, J = 8,4 Hz, IH); 1 ⁹ F NMR (376 MHz, acetone-de) δ -122.99, -127.03, -128.36

*H NMR (400 MHz, acetone-cfe) δ 10.20 (s, IH), 9,77 (s, IH), 9.56 (s, IH), 8.17 (td, J = 8.8, 5,6 Hz, IH), 8,04 (d, J = 2.6 Hz, IH), 7,81 (dd, J = 8.8, 2.6 Hz, IH),

ESIMS m/z 668

F1600 7.65 - 7.32 (m, 5H), 7.20 (td, J - ([M + H] ⁺ )

9.3, 2.1 Hz, IH), 6.46 (t, J - 53.5 Hz, IH), 3.62 (d, J = 8.4 Hz, IH),

3,37 (d, J = 8.4 Hz, IH); ! ⁹ F NMR (376 MHz, acetone-c/e) δ -123,10, -127,07, -128.45

^! H NMR (400 MHz, acetone-cfe) δ 10,19 (s, IH), 9,76 (s, IH), 9,56 (s, IH), 8.17 (td, J = 8,8, 5,6 Hz, IH), 8.04 (d, J = 2,7 Hz, IH), 7,81 (dd, J = 8.7, 2,7 Hz, IH),

ESIMS m/z 624

F1601 7,56 - 7.35 (m, 5H), 7,20 (td, J - ([M + H] ⁺ )

9.3, 2.0 Hz, IH), 6.46 (t, J = 53,5 Hz, IH), 3.63 (d, J - 8.3 Hz, IH),

3.36 (d, J ^~ 8.4 Hz, IH); 1 ⁹ F NMR (376 MHz, acetone-cfc) δ -123.07, -127.05, -128.42

^l NMR (400 MHz, DMSG-de) δ

10.93 (s, 1H), 10.79 (s, 1H), 10.51 (s, 1H), 7.92 (dd, J - 7.7, 2.3 Hz, 2H), 7.82 (d, J - 2.0 Hz, 1H), 7.73 (ddd, J = 14.8, 8.6, 4.0

ESIMS m/z 736 Hz, 2H), 7.56 (d, J = 8.8 Hz, 1H),

F1623

([M + H] ) 7,27 (dd, J = 9.9, 8,1 Hz, 1H),

6,54 (t, J = 53,2 Hz, 1H), 3,63 (d, J = 8.5 Hz, 1H), 3.54 (d, J =

8.5 Hz, 1H);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -120.68, -124.25, -125.76 l NMR (400 MHz, DMSO-de) δ 10.95 (s, 1H), 10.79 (s, 1H), 10.51 (s, 1H), 7.94 (d, J = 2.6 Hz, 1H), 7.85 - 7.67 (m, 4H), 7.57 (d, J ^~ 8.8 Hz, 1H), 7.33 -

ESIMS m/z 734

F1624 7.24 (m, 1H), 7.17 (dd, J = 9.8,

([M + H] ⁺ )

8.4 Hz, 1H), 6,55 (t, J = 53.2 Hz, 1H), 3.44 (s, 2H);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -117.03, -120.64 (d, J = 2,7 Hz), -124.21 (d, J = 2,8 Hz), -125,81

*H NMR (400 MHz, acetone-de) δ

10,23 (s, 1H), 9.52 (s, 1H), 9.25 (s, 1H), 8.20 - 8.08 (m, 1H), 8.03 (d, J = 2,6 Hz, 1H), 7,82

(ddd, J = 10.3, 6.0, 2.3 Hz, 3H), 7.47 (dt, J - 8.3, 5.1 Hz, 2H), 7.15 (td, J - 9.2, 1.9 Hz, 1H),

ESIMS m/z 709

F162S i[M + H] ⁺ ) 5.19 (ddd, J - 7.9, 6.3, 1.1 Hz,

1H), 3.71 (d, J = 8.3 Hz, 1H),

3.44 (d, J = 8.3 Hz, 1H), 2.82 - 2,54 (in, 3H), 2.40 (dddd, J = 10,2, 8.9, 7,9, 4.9 Hz, 1H);

¹⁹ F NMR (376 MHz, acetone-de) δ -61.83, -117.54, -123,11, -128.67

lH NMR (400 MHz, acetone-de) δ 10,22 (s, 1H), 9.48 (s, 1H), 8.75

(s, 1H), 8,14 - 7.99 (m, 2H), 7.82 (dq, J - 11.2, 2.8 Hz, 3H), 7.53 - 7.43 (m, 2H), 7.11 (td, J = 9.2, 2.0 Hz, 1H), 4.48 (dd, J - 8.7, 4,8 Hz, 1H), 3,96 (dq, J =

ESIMS m/z 723 8.8, 6.2 Hz, 1H), 3.71 (d, J = 8.3

F1626

([M + H] ⁴ ) Hz, 1H), 3.43 (d, J = 8.3 Hz, 1H),

2.41 - 2,24 (m, 1H), 2,23 - 2.00 (in, 2H), 1.78 (dp, J = 14,5, 7.4 Hz, 1H), 1.71 - 1.45 (m, 2H), 0.98 (t, J = 7.5 Hz, 3H); 1 ⁹ F NMR (376 MHz, acetone-de) δ -61.84, -117.55, -123.26, -128.95

H NMR (400 MHz, CDCi ₃ ) δ 9.33

(s, IH), 8.30 (cl, J - 2.1 Hz, IH),

7,96 (dd, J - 8.8, 2,7 Hz, IH), 7.66 (d, J - 2.7 Hz, IH), 7.59 (d, J = 7.7 Hz, IH), 7.52 - 7,41 (m,

ESIMS m/z 579

F1666 3H), 7,37 (dd, J = 18.7, 8,3 Hz,

([Μ + ΗΓ)

2H), 6,82 - 6.72 (m, IH), 3.74 (s, 2H), 3.60 (d, J = 8,2 Hz, IH),

-62.63, -134.53, -145,15

^X H NMR (400 MHz, acetone-e/5) δ 10.19 (s, IH), 9.50 (s, IH), 9.22 (s, IH), 8.10 (td, J = 8,7, 5,6 Hz,

IH), 8,03 (d, J - 2.6 Hz, IH), 7.86 - 7.77 (m, 3H), 7.48 (eit, J =

10.1, 5.1 Hz, 2H), 7.14 (td, J -

ESIMS m/z 688

F1667 9.2, 2.0 Hz, IH), 4.80 (q, J = 6.8

([M + H] ⁺ )

Hz, IH), 3,71 (d, J = 8.3 Hz, IH), 3,43 (d, J = 8.3 Hz, IH), 1.74 (d,

J - 6,8 Hz, 3H);

1 ⁹ F NMR (376 MHz, acetone-de) δ -61.80, -117,55, -123,17, -128.61

*Η NMR (400 MHz, acetone-cfe) δ 10.19 (s, IH), 9,48 (s, IH), 9.04 (s, IH), 8.12 - 7.98 (m, 2H), 7,82 (dq, J = 8.8, 2,6 Hz, 3H), 7.47 (dt, J - 8.1, 5.0 Hz, 2H), 7.11 (td, J - 9.2, 1.9 Hz, IH),

ESIMS m/z 702

F166S 4.56 (dt, J - 7.7, 6.3 Hz, IH),

([M + H] ⁺ )

3.71 (d, J = 8.3 Hz, IH), 3.42 (d, J = 8.3 Hz, IH), 2.95 (q, J = 14.9

Hz, 2H), 1.64 - 1.52 (m, 3H); ) ⁹ F NMR (376 MHz, acetone-ck) δ -61.81, -117.57, -122.89, -128.32

^X H NMR. (400 MHz, acetone-cfe) δ 10.18 (s, H), 9,50 (s, IH), 9.22 (s, IH), 8.11 (tt, J = 8.7, 4,8 Hz,

IH), 8,03 (d, J = 2.6 Hz, IH), 7.91 - 7.77 (m, 3H), 7.48 (dt, J -

9,7, 5.1 Hz, 2H), 7.15 (td, J -

ESIMS m/z 702 9.2, 2.0 Hz, IH), 4.61 (t, J - 6.7

F 3,669

([M + H] ⁺ ) Hz, IH), 3,71 (d, J = 8.3 Hz, IH),

3,43 (d, J = 8.3 Hz, IH), 2.24 -

1,92 (m, 2H), 1.13 - 0.99 (m,

3H);

¹⁹ F NMR (376 MHz, acetone-c/5) δ -61.84, -117,52, -123,09, -128.55 rt NMR (400 MHz, acetone-de) δ

10.19 (s, 1H), 9,48 (s, 1H), 8.90

(s, IN), 8.11 - 7.98 (m, 2H), 7.84 - 7.71 (m, 2H), 7.55 - 7.44

ESIMS m/z 650 (m, 2H), 7.34 (t, J = 8.6 Hz, 1H),

F1716

([Μ + ΗΓ) 7.10 (td, J = 9.3, 2.0 Hz, 1H),

3.66 - 3.58 (m, 1H), 3,35 (d, J =

8,3 Hz, 1H), 2,16 (s, 3H); 1 ⁹ F NMR (376 MHz, acetone-de) δ

-110.14, -123.27, -128.77

^X H NMR (400 MHz, acetone-de) δ 10.20 (s, 1H), 9,47 (s, 1H), 8,82

(s, 1H), 8,11 - 7.98 (m, 2H), 7.84 -- 7,71 (m, 2H), 7.54 - 7.43 (m, 2H), 7,33 (t, J - 8,6 Hz, 1H),

ESIMS m/z 664

F1717 7,10 (td, J ^~ 9.3, 2,0 Hz, 1H),

([M + H] ⁺ )

3,66 - 3.58 (m, 1H), 3.34 (d, J - 8.3 Hz, 1H), 2,48 (q, J = 7.6 Hz,

2H), 1.18 (t, J = 7.6 Hz, 3H); 1 F NMR (376 MHz, acetone-de) δ -110.10, -123.20, -128.73

Ή NMR (400 MHz, acetone-de) δ 10,16 (s, 1H), 9,49 (s, 1H), 9.26 (s, 1H), 8.12 (td, J = 8,8, 5,6 Hz, 1H), 8,03 (d, J = 2.5 Hz, 1H), 7.82 (dd, J = 8.8, 2.6 Hz, 1H), 7,75 (dd, J = 6.6, 2.3 Hz, 1H),

ESIMS m/z 718

FI7I8 7,56 - 7.45 (m, 2H), 7.34 (t, J =

([M + H] ⁺ )

8.6 Hz, 1H), 7.16 (td, J ^~ 9.3, 2.0 Hz, 1H), 3.66 - 3.53 (rr>, 3H), 3,36 (d, J - 8.3 Hz, 1H); 1 ⁹ F NMR (376 MHz, acetone-de) δ -63.60, -110.17, -123.32, - 128.53

^; H NMR (400 MHz, DMSO-de) δ 11.35 (s, 1H), 10.97 (s, 1H), 10,54 (s, 1H), 7,94 (t, J = 2.6 Hz, 2H), 7,84 - 7,70 (m, 4H), 7,57

ESIMS m/z 724

F1719 (d, J - 8,8 Hz, 1H), 7,32 (t, J =

([M + H]-) 9,2 Hz, 1H), 3,72 (d, J = 8.5 Hz,

1H), 3.53 (d, J = 8,5 Hz, 1H); 1 ⁹ F NMR (376 MHz, DMSO-de) δ -61,15, -63.04, -121.25, -124.53

NMR (400 MHz, acetone-cfc) δ

10.23 (s, IH), 9.48 (s, IH), 8.91 (s, IH), 8.08 (td, J - 8.7, 5.6 Hz, IH), 8.02 (d, J ^~ 2.6 Hz, IH), 7,82 (ddd, J = 8.9, 5.5, 1.7 Hz, 3H), 7,48 (dt, J = 8.2, 5.1 Hz,

ESIMS m/z 683 2H), 7,13 (td, J = 9.2, 2,0 Hz,

F1720

([M + H] ^" ) IH), 3.95 (q, J = 6,7 Hz, IH),

3.71 (d, J = 8.3 Hz, IH), 3.50 - 3,40 (m, 4H), 1.41 (d, J = 6.7 Hz,

3H);

¹⁹ F NMR (376 MHz' acetone-cfc) δ

-61.86, -117.58, -123.30, -128.90

^X H NMR (400 MHz, acetone-d ₆ ) δ 10.19 (s, IH), 9.46 (s, IH), 9.00 (s, IH), 8.11 - 7.98 (m, 2H), 7,82 (td, J = 8.7, 8.3, 2.6 Hz, 3H), 7.47 (dt, J = 8.3, 5.1 Hz, 2H), 7.10 (td, J = 9.2, 1.9 Hz, IH), 4,15 (dd, J = 6.8, 4,6 Hz,

ESIMS m/z 711 IH), 3,71 (d, J = 8.3 Hz, IH),

FI721

([M + H] ⁺ ) 3.42 (d, J = 8.3 Hz, IH), 3.01

(dt, J = 11,3, 5,5 Hz, IH), 2,91 (dt, J = 9,4, 6,1 Hz, IH), 2,41 - 2.28 (m, IH), 2.27 - 2.05 (m,3H);

¹⁹ F NMR (376 MHz, acetone-do) δ -61.83, -117.53, -123.10, - 128.62

^V H NMR (400 MHz, acetone-de) δ 10.22 (s, IH), 9.47 (s, IH), 8.91

(s, IH), 8.10 - 7.98 (m, 2H), 7.81 (ddd, J = 11,4, 6,0, 2,6 Hz,

3H), 7,52 - 7,42 (m, 2H), 7,09

(td, J = 9,2, 1,9 Hz, IH), 4,03 (ddd, J = 11.3, 4.2, 1.7 Hz, IH),

3.81 (dd, J = 9.8, 5.5 Hz, IH),

ESIMS m/z 709 3.71 (d, J = 8.3 Hz, IH), 3.55

F1722

([M + H] ⁺ ) (dd, J - 11.3, 9.7 Hz, IH), 3.46 - 3.33 (m, 2H), 2.79 (tt, J - 10.2,

4.0 Hz, IH), 2.09 (dd, J ^~ 6.0, 3,6 Hz, IH), 1,84 (dtd, J = 13.0,

11,2, 4.3 Hz, IH), 1.76 - 1.52

(m, 2H);

1 ⁹ F NMR (376 MHz, acetone-de) δ -61.83, -117,56, -12.3,09, -128.57 H NMR (400 MHz, acetone-de) δ

10.20 (s, IH), 9.48 (s, IH), 8.77 (s, IH), 8.08 (td, J - 8.8, 5.6 Hz,

IH), 8.02 (d, J ^~ 2.7 Hz, IH), 7.87 - 7.77 (m, 3H), 7.48 (dt, J =

9.6, 5.1 Hz, 2H), 7.12 (td, J = 9.2, 2.0 Hz, IH), 4.03 (q, J = 6.7

ESIMS m/z 72b Hz, IH), 3.71 (d, J = 8.3 Hz, IH),

F1746

([M + H] ^"1" ) 3,50 - 3.39 (m, 2H), 3.35 (dd, J

= 9.0, 6.8 Hz, IH), 1.94 (dp, J ----- 13.3, 6.7 Hz, IH), 1,44 (d, J = 6.7 Hz, 3H), 0,96 (dd, J = 6.7,

1.6 Hz, 6H);

1 ⁹ F NMR (376 MHz, acetone-de) 6 -61.85, -117.56, -123.26, -128.91

Ή NMR (400 MHz, acetone-de) δ 10,23 (s, IH), 9.49 (s, IH), 9.00 (s, IH), 8,10 (td, J = 8,7, 5.6 Hz,

IH), 8,03 (d, J = 2.7 Hz, IH), 7,87 - 7,77 (m, 3H), 7,48 (dt, J =

10,0, 5.1 Hz, 2H), 7,14 (td, J =

ESIMS m/z 751

F1747 9.3, 2,0 Hz, IH), 4.44 - 4.13 (m,

(| 1 + H] ⁺ )

3H), 3.71 (d, J = 8.3 Hz, IH), 3.44 (d, J ------ 8.3 Hz, IH), 1.53 (d,

J - 6.7 Hz, 3H);

1 ⁹ F NMR (376 MHz, acetone-de) δ -61.86, -75.08, -117.57, -123.22,

-128,81

^V H NMR (400 MHz, acetone-de) δ 10,19 (s, IH), 9,49 (s, IH), 8.73 (s, IH), 8.10 (td, J = 8.8, 5,6 Hz, IH), 8.02 (d, J = 2,7 Hz, IH), 7,82 (ddd, J = 8.9, 7,2, 4.1 Hz, 3H), 7.48 (dt, J = 9.8, 5,3 Hz,

ESIMS m/z 681 2H), 7,13 (td, J = 9.2, 2,0 Hz,

F1748

([M + H] ^"1" ) IH), 3.72 (d, J = 8.3 Hz, IH),

3.47 -- 3,36 (m, 2H), 3.30 (qd, J = 5,1, 2.0 Hz, IH), 1.42 (d, J =

5.1 Hz, 3H);

1 ⁹ F NMR (376 MHz, acetone-de) δ -61.84, -117.63, -123.33, -128.87

^! H NMR (400 MHz, DMSO-de) δ 10.94 (s, IH), 10.36 (s, IH), 7,90

(d, J = 2,4 Hz, IH), 7,80 - 7,68

105- ESIMS m/z 549

F1749 (m, 2H), 7,59 - 7.44 (m, 3H),

108 ([M + H] ⁴ )

7.40 - 7.32 (m, IH), 7,13 (br t, J

= 8.6 Hz, IH), 3.60 (d, J = 8.3 Hz, IH), 3.47 (d, J = 8,3 Hz, IH) *H NMR (400 MHz, DMSG-cfe) δ

10.97 (s, IH), 10.48 (s, IH), 10.44 (s, IH), 7.94 (d, J - 2.6 Hz, IH), 7.85 (dd, J - 19.0, 5.9

H RMS- ESI { /z) Hz, 2H), 7.78 - 7.67 (m, 2H), [M + ] ⁺ caicd for 7,63 - 7.54 (m, 2H), 7.25 (td, J =

115-

F1754 C27Hl6Ci ₃ F ₆ N304, 9,4, 8.9, 1,7 Hz, IH), 3,70 (d, J =

120

665.0111; found, 8.5 Hz, IH), 3.52 (d, J = 8,5 Hz, 665.0102 IH), 2,45 (s, 3H);

1 ⁹ F NMR (376 MHz, DMSO-cfe) δ -59.91 (d, J = 12.3 Hz), -116,94 (q, J = 12.6 Hz), -120,05, -123.75

^X H NMR (400 MHz, acetone-cfe) δ 10.20 (s, IH), 9.52 (s, IH), 9.35 (s, IH), 8.12 (td, J - 8.7, 5.5 Hz,

IH), 8.04 (d, J - 2.6 Hz, IH), 7.87 - 7.77 (m, 3H), 7.53 - 7.43

(m, 2H), 7.16 (td, J = 9.3, 2.0

ESIMS m/z 678

F1755 Hz, IH), 4.11 (q, J = 7.2 Hz, IH),

([M + H] )

3,72 (d, J = 8.3 Hz, IH), 3.43 (d, J = 8.3 Hz, IH), 1.65 (d, J = 7,2

Hz, 3H);

¹⁹ F NMR (376 MHz, acetone-cfe) δ -61.86, -117.60, -123.38, -128.65

*H NMR (400 MHz, acetone-cfe) δ 10.19 (s, IH), 9,51 (s, IH), 9.33 (s, IH), 8.12 (td, J = 8.7, 5.6 Hz,

IH), 8.04 (d, J ^~ 2.6 Hz, IH), 7.87 - 7.78 (m, 3H), 7.48 (dd, J = 9.3, 7,5 Hz, 2H), 7,17 (td, J =

ESIMS m/z 692 9.3, 2.1 Hz, IH), 4.01 (t, J = 6,9

F1756

([M + H] ^" ) Hz, IH), 3.72 (d, J = 8.3 Hz, IH),

3,44 (d, J = 8,3 Hz, IH), 2,11 (dt, J = 14.4, 7,1 Hz, 2H), 1,16

(t, J = 7.4 Hz, 3H);

1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61.84, -117.63, -123,39, -128.63.

^X H NMR (400 MHz, acetone-cfe) δ

10.20 (s, IH), 9.46 (s, IH), 8.87 (s, IH), 8.09 (tcl, J - 8.8, 5.6 Hz,

IH), 8.02 (d, J - 2.6 Hz, IH), 7.87 - 7.78 (m, 3H), 7.48 (dt, J = 9.7, 5.4 Hz, 2H), 7.13 (td, J = 9.2, 2,0 Hz, IH), 3,88 (dd, J =

ESIMS m/z 71 6,5, 4.9 Hz, IH), 3.73 (ddd, J =

FI7S7

([M + H] ⁺ ) 13.9, 6.9, 1.7 Hz, 2H), 3.62 (dq, J

= 9,4, 7.0 Hz, IH), 3.43 (d, J = 8,3 Hz, IH), 1,94 - 1.70 (m, 2H), 1.26 (t, J = 7.0 Hz, 3H), 1.00 (t, J

- 7.4 Hz, 3H);

1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61.88, -117.61, -123.23, - 128.86 H NMR (400 MHz, aceto ne-cfc) δ

10.17 (s, 1H), 9.49 (d, J - 18.7 Hz, 1H), 8.13 (td, J - 9.0, 5.8 Hz,

IH), 8.04 (t, J ^~ 4.0 Hz, 1H), 7.82 (ddd, J = 14,6, 7.9, 2,7 Hz, 3H), 7,48 (t, J = 9.1 Hz, 2H),

ESIMS /z 72b 7.16 (td, J = 9.2, 2.1 Hz, IH),

F1761

([M + H] ⁴ ) 3.72 (d, J = 8.3 Hz, IH), 3.61 (q,

J = 7.1 Hz, 2H), 3.43 (d, J = 8.3 Hz, IH), 1.43 (d, J = 66.7 Hz, 9H), 1.24 - 1.06 (m, 3H); 1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61.89, -117.63, -124,27, -129.88

H NMR (400 MHz, acetone-do) δ 10,16 (s, IH), 9.25 (s, IH), 8.01 (d, J - 2.5 Hz, IH), 7.90 - 7.77 (m, 3H), 7.46 (ddd, J = 12.7, 8.9, 6.3 Hz, 3H), 6.91 (ddd, J = 11,4,

ESIMS m/z 625 9,0, 2.0 Hz, IH), 4.46 (s, IH),

FI762

([M + H] ⁴ ) 3,72 (d, J = 8.3 Hz, IH), 3.47 - 3.33 (m, 3H), 1.20 (t, J = 7.1 Hz,

3H);

¹⁹ F NMR (376 MHz, acetone-do) δ -61.88, -117.63, -133.96, -141.65

*Η NMR (400 MHz, acetone-cfc) δ 10.20 (s, IH), 9.59 (d, J = 49.2 Hz, IH), 8.42 - 8.16 (m, IH), 8.14 - 8.01 (m, IH), 7.95 - 7.73 (m, 3H), 7.48 (dd, J - 11.6, 8,9

ESIMS m/z 692 Hz, 2H), 7.41 - 7,16 (m, IH),

F1763

([M + H] ⁴ ) 3.90 - 3.67 (m, 3H), 3.62 (s,

2H), 3.44 (d, J = 8,3 Hz, IH), 1,17 (dt, J - 37,9, 7.2 Hz, 3H); 1 ⁹ F NMR (376 MHz, acetone-d ₆ ) δ -61.87, -117.58, -123,90, -129.01

^J H NMR (400 MHz, acetone-de) δ

10,20 (s, IH), 9.82 - 9,49 (m, IH), 8.35 (dtd, J = 39,7, 8.9, 5.7 Hz, IH), 8.08 (dt, J - 16.1, 2,7 Hz, IH), 7.90 - 7.68 (m, 3H), 7.57 - 7.41 (m, 2H), 7.33 (tdd, J

ESIMS m/z 706

F1764 = 9,5, 4.7, 1.9 Hz, IH), 3.75 (dt,

([M + H] ⁴ )

J = 14.1, 5,8 Hz, 4H), 3,44 (d, J = 8,3 Hz, IH), 1,66 - 1.33 (m, 3H), 1.33 - 1.00 (m, 3H); 1 ⁹ F NMR (376 MHz, acetone-de) δ -61.87, -117,60, -124,55, NMR (400 MHz, acetone-c/e) δ

10.21 (s, IH), 9.50 (s, IH), 9.30 (s, IH), 8.21 (s, IH), 8.12 (td, J - 8.8, 5.6 Hz, IH), 8.06 - 8.01 (m, IH), 7.82 (dd, J = 8.7, 2.6 Hz, IH), 7.70 (s, IH), 7.61 (d, J = 9.5 Hz, IH), 7.52 (dd, J = 24,6,

ESIMS /z 737

F1773 8,7 Hz, 2H), 7,16 (t, J = 9.3 Hz,

([M + H] ⁴ )

IH), 5.08 (q, J = 6,7 Hz, IH), 3,77 (d, J = 8.3 Hz, IH), 3.51 (d, J = 8.3 Hz, IH), 1.67 (d, J = 6,8

Hz, 3H);

¹⁹ F NMR (376 MHz, acetone-ce) δ -59.78, -63.20, -111.80, -123.46,

-128.92

^X H NMR (400 MHz, acetone-do) δ 10.24 (s, IH), 9.53 (s, IH), 9.31

(s, IH), 8.21 - 8.02 (m, 2H), 7.86 - 7.69 (m, 4H), 7.67 (t, J = 7,7 Hz, IH), 7,48 (d, J = 8.8 Hz,

ESIMS m/z 705

FI774 IH), 7.16 (td, J = 9,3, 2.0 Hz,

([M + H] ⁴ )

IH), 4.87 (s, 2H), 3,73 (d, J = 8,3 Hz, IH), 3,46 (d, J = 8.4 Hz,

IH);

¹⁹ F NMR (376 MHz' acetone-ce) δ

-61.64, -63.07, -123.13, -128.55

*H NMR (400 MHz, acetone-c/e) δ 10.21 (s, IH), 9,50 (s, IH), 9.30 (s, IH), 8.19 - 8.01 (m, 2H), 7.82 (dd, J - 8.7, 2.6 Hz, IH), 7.81 - 7.69 (m, 3H), 7.67 (t, J = 7.7 Hz, IH), 7.48 (d, J = 8,8 Hz,

ESIMS m/z 719

F1775 IH), 7,16 (td, J = 9.2, 2,0 Hz,

([M + H] ⁴ )

IH), 5.08 (q, J = 6,8 Hz, IH), 3,73 (d, J = 8.3 Hz, IH), 3.45 (d, J = 8.4 Hz, IH), 1.67 (d, J = 6.8

Hz, 3H);

¹⁹ F NMR (376 MHz, acetone-c/e) δ -59.77, -63.07, -123.42, -128.89

^! H NMR (400 MHz, CDC ) δ 9,03 (s, IH), 8,42 (d, J = 2,5 Hz, IH), 8,32 (td, J - 8.8, 5.4 Hz, IH), 7.90 (d, J = 2.7 Hz, IH), 7.78 (dd. J = 8.7, 2.6 Hz, IH), 7.48 - 7.34 (m, 2H), 7.20 (ddd, J = 8.6,

ESIMS m/z 808

F1776 4.7, 2.3 Hz, IH), 7.11 (t, J = 8.3

([M + H] ⁴ )

Hz, IH), 6.98 (td, J = 9.1, 1.8 Hz,

IH), 3,52 (d, J = 8.1 Hz, IH), 2.85 (d, J = 8.1 Hz, IH), 1.46 (s,

18H);

⁹ F NMR (376 MHz, CDCi ₃ ) δ -107.69, -122.88, -132.77 NMR (400 MHz, acetone-cfe) δ

10.19 (s, IH), 9.51 (s, IH), 9.31 (s, IH), 8.12 (td, J = 8.8, 5.6 Hz,

IH), 8.03 (d, J ^~ 2.6 Hz, IH), 7.78 (ddd, J = 23.3, 7.7, 2,4 Hz, 2H), 7,54 - 7,43 (in, 2H), 7,33 (t,

ESIMS m/z 748 J = 8.6 Hz, IH), 7.16 (td, J = 9.2,

F1781

([M+Hr) 2,0 Hz, IH), 5.09 (q, 3 = 6,8 Hz,

IH), 3.62 {6,3 = 8.3 Hz, IH), 3,35 (d, 3 = 8.2 Hz, IH), 1.67 (d,

J = 6.8 Hz, 3H);

1 ⁹ F NMR (376 MHz, acetone-cfe) δ -59.75, -110.11, -123.39, -128.86

lH NMR (400 MHz, acetone-a%) δ 10.38 (s, IH), 10.20 (s, IH), 9.59 (s, IH), 8.22 (td, J - 8.8, 5.6 Hz,

IH), 8,05 (d,-7 = 2.6 Hz, IH), 7.87 - 7.77 (m, 3H), 7.48 (t, J = 9.6 Hz, 2H), 7.26 (td, J = 9.2, 2,0

ESIMS m/z 821 Hz, IH), 3,72 (d, J = 8.3 Hz, IH),

FI782

([M + H] ⁴ ) 3.43 (d, 3 = 8,3 Hz, IH);

1 ⁹ F NMR (376 MHz, acetone-de) δ -61.86, -82.44, -82.82, -83.92, -84.27, -117.61, -118.95, -123.31, -125.70, -127.38, -128.06, -128.43, -131.03, -131.71, -134,85, -135.52

*H NMR (400 MHz, acetone-cfe) δ 10.44 (s, IH), 10,21 (s, IH), 9.59 (s, IH), 8.22 (td, 3 - 8.9, 5.6 Hz,

IH), 8.05 (d, 3 = 2.6 Hz, IH), 7.83 (ddd, J = 11.4, 7.7, 2,6 Hz, 3H), 7,48 (t, J = 9.7 Hz, 2H), 7,26 (td, J = 9,3, 2.0 Hz, IH), 3.72 (d, J = 8,3 Hz, IH), 3.44 (d,

ESIMS /z 871

F1783 J = 8,3 Hz, IH);

([M + H] )

1 ⁹ F NMR (376 MHz, acetone-cfe) δ -61.90, -78.47, -78.89, -92.05, -92.47, -117,65, -123.02, -123.37, -123.77, -124.73, -125.42, -127.13, -127.85, -128.45, -133.53, -134.29, -138.70, -139.42, -141.07,

-141.84

ESIMS m/z 810

F1784

([M + H] ^" )

^v ri NMR (400 Hz, DMSO-c/e) rotamers δ 11.62 (s, 0.3H), 11.45 (s, 0.7H), 10.98 (s, 0.3H), 10.76 (s.0.7H), 7.91 (d. J - 2.4 Hz, 0.3H), 7.90 - 7.85 (m, 0.3H), 7.85 - 7.76 (m, 1.7H), 7.76 - 7,67 (m, 1.3H), 7,65 - 7.54 (m,

1.3H), 7.53 - 7,39 (m, 1.7H), 7.31 (d, J = 8.7 Hz, 0.7H), 7.20

ESIMS m/z 708

F1795 (t, J = 9,2 Hz, 0.7H), 3.69 (d, J =

([M + H] ^~ )

8,6 Hz, 0.3H), 3.65 (d, J = 8.6 Hz, 0.7H), 3.50 (d, J = 8,1 Hz, 0.3H), 3,41 (d, J - 8.7 Hz, 0.7H), 3.34 (s, 2H), 3.14 (s, 1H); 1 ⁹ F NMR (376 MHz, DMSO-ce) rotamers δ -59,96 (dd, J = 33.6,

12,5 Hz), -73.84, -116.64, -116.79 - -117.10 (m), -117.78 (d, J = 3.9 Hz), -121.92, -122,51 l NMR (400 MHz, DMSO-c/e) rotamers δ 10,98 (s, 0.3H), 10.76 (s, 0.7H), 10.19 (s, 0.3H), 10.07

(s, 0.7H), 7,90 (d, J = 2.4 Hz, 0.3H), 7.87 (d, J = 6.9 Hz, 0.3H), 7.85 - 7.77 (m, 1.7H), 7.75 - 7.67 (m, 1H), 7.64 - 7.55 (m, 1.7H), 7.53 - 7.43 (m, 0.6H), 7.39 - 7.27 (m, 1.7H), 7.09 (t, J

ESIMS m/z 738 = 9.1 Hz, 0.7H), 4,88 (s, 0.6H),

F1796

([M + H] ⁺ ) 4,77 (s, 1.4H), 3.72 - 3.63 (m,

1H), 3,49 (d, J = 8.5 Hz, 0.3H), 3.42 (d, J = 8.5 Hz, 0.7H), 3.32 (s, 2H), 3.13 (s, 1H);

1 ⁹ F NMR (376 MHz, DMSO-ce) rotamers δ -59,24, -59,35, -59,92 (d, J = 12,5 Hz), -60,00 (d, J = 12.4 Hz), -116.16, -116,93 (q, J - 13.0 Hz), -117.21, -122.07,

-122.56

^v ri NMR (400 MHz, DMSO-de) rotamers δ 10.99 (s, 0.3H), 10.75 (s, 0.7H), 9.70 (s, 0.3H), 9.48 (s,

0.7H), 7.93 - 7.77 (m, 2.3H), 7.76 - 7.64 (m, 1H), 7.64 - 7.50 (m, 1.7H), 7.49 - 7.41 (m, 0.6H), 7.36 - 7,24 (m, 1.7H), 7,05 (t, J = 9,1 Hz, 0.7H), 4.02 (q, J = 6,6 Hz, 0.3H), 3,92 (s, 0.7H), 3.68 (t,

ESIMS m/z 712

F1797 J = 7.0 Hz, 1H), 3.63 - 3,52 (m,

([M + H] ^~ )

1H), 3,50 (d, J = 8.5 Hz, 1H), 3.43 (d, J = 8.5 Hz, 1H), 3.31 (s,

2H), 3.12 (s, 1H), 1.35 (d, J - 6.7 Hz, 1H), 1.31 - 1.05 (m, 5H);

¹⁹ F NMR (376 MHz, DMSO-ce) rotamers δ -59.89 - -59.94 (m), -59.94 - -60.00 (m), -116.93 (q, J = 12.2 Hz), -116,17, -117,52 (d, J = 5.2 Hz), -122.38, -123,29 l NMR (400 MHz, DMSO-c/ ₆ ) rotamers δ 10,99 (s, 0.3H), 10.75 (s, 0.7H), 9.67 (s, 0.3H), 9,46 (s, 0.7H), 7,93 - 7.77 (m, 3H), 7.76 - 7.63 (m, 1H), 7.63 - 7.56 (m,

1.3H), 7.56 - 7,42 (m, 0.6H), 7.35 - 7.24 (m, 1.4H), 7.05 (t, J - 9.1 Hz, 0.7H), 4.46 (dd, J = 8.3, 5.1 Hz, 0.3H), 4.42 - 4.31 (m, 0.7H), 4.01 (q, J = 7.3 Hz,

ESIMS m/z 710 0.3H), 3.93 (s, 0.7H), 3.85 (q, J

F1798

([Μ + ΗΓ) = 7.2 Hz, 0.3H), 3.80 - 3.72 (m,

0.7H), 3.72 - 3,64 (m, 1H), 3,50 (d, J = 8,5 Hz, 0.3H), 3,43 (d, J = 8.6 Hz, 0.7H), 3,31 (s, 2H), 3.11 (s, 1H), 2,29 - 2.04 (m, 1H), 2.02 - 1,72 (m, 4H);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -59.88 - -59.99 (m), -116.31, -116.92 (qd, J = 12.5, 5.0 Hz), -117.57 (d, J = 5,4 Hz), -122,36,

-123.20

*H NMR (500 MHz, DMSG-cfe) δ

11.35 (s, 1H), 10.97 (s, 1H), 10.76 (s, 1H), 7.98 (dd, J - 6.9, 2.7 Hz, 1H), 7.91 (d, J - 2.6 Hz,

1H), 7.87 (dd, J = 6.9, 2.3 Hz,

H RMS- ESI (m/z) 1H), 7.83 (ddd, J = 7.5, 4.5, 2.2 [M + ] ⁺ caicd for Hz, 1H), 7.76 (dd, J = 8.8, 2.6

F1815 C26Hl4Ci ₃ F ₈ N303, Hz, 1H), 7.65 - 7,54 (m, 3H),

672.9973 found, 7,47 - 7.27 (m, 1H), 3,69 (d, J = 672,9973 8,4 Hz, 1H), 3,51 (d, J = 8.5 Hz,

1H);

¹⁹ F NMR (471 MHz, DMSO-de) δ -59.91, -59.94, -73.86, -116.92, -116.93, -116.94, -125.40,

-125.40

*H NMR (400 MHz, DMSO-de) δ 10.98 (s, 1H), 10.71 (s, 1H), 10.51 (s, 1H), 9.21 (d, J = 1.8 Hz, 1H), 7.94 (d, J = 2.6 Hz, 1H), 7.90 - 7.80 (m, 2H), 7.79 - 7.69

(rrt, 2H), 7,63 - 7,52 (m, 2H),

ESIMS m/z 691

F 1816 7,28 (t, J = 9.1 Hz, 1H), 7.06 (d,

([M + H]-)

J = 1.7 Hz, 1H), 3.69 (d, J = 8,4 Hz, 1H), 3,51 (d, J = 8,5 Hz, 1H); 1 ⁹ F NMR (376 MHz, DMSO-de) δ -59,92 (d, J - 12.6 Hz), -116.95 (q, J - 12.6 Hz), -120.42, -124.22

*H NMR (400 MHz, DMSO-de) δ 10.97 (s, 1H), 10.77 (s, 1H), 10.52 (s, 1H), 8.77 (d, J - 1.8 Hz, 1H), 8.13 (s, 1H), 7.95 (d, J = 2.6 Hz, 1H), 7.91 - 7,80 (m, 2H), 7,79 - 7.68 (m, 2H), 7,66 -

ESIMS m/z 707

F1817 7.52 (m, 2H), 7,30 (t, J = 9.2 Hz,

([M + H] ^" )

1H), 3.69 (d, J = 8,5 Hz, 1H),

3.51 (d, J = 8,5 Hz, 1H); 1 ⁹ F NMR (376 MHz, DMSO-de) δ -59,91 (d, J = 12,6 Hz), -116,94 (q, J - 12.2 Hz), -120.27, -124.02

*H NMR (400 MHz, DMSO-de) δ 10.97 (s, 1H), 10.87 (s, 1H), 10.52 (s, 1H), 8.87 (d, J = 1.9 Hz, 1H), 7.94 (d, J = 2.6 Hz, 1H), 7.90 - 7.80 (m, 2H), 7.79 - 7.69

(m, 2H), 7.63 - 7.54 (m, 2H),

ESIMS m/z 691

FI8IS 7,34 - 7.26 (m, 2H), 3,69 (d, J =

([M + H] ^' )

8,4 Hz, 1H), 3,51 (d, J = 8.5 Hz,

1H);

¹⁹ F NMR (376 MHz, DMSO-de) δ -59,91 (d, J = 12.4 Hz), -116.94 (q, J - 12.6 Hz), -120.34, -124.13 ^X H NMR (400 MHz, Acetone-ofe) δ

10.25 (s, IH), 9.49 (s, IH), 9.06 (s, IH), 8.13 - 8.00 (m, 2H), 7.82 (dq, J - 9.2, 2.6 Hz, 3H), 7.47 (dt, J = 8.1, 5.1 Hz, 2H),

ESIMS m/z 747 7.11 (td, J = 9.3, 2.0 Hz, IH),

F1S36

([M + H] ⁴ ) 3.71 (d, J = 8.3 Hz, IH), 3.44 (d,

J = 8.3 Hz, IH), 2,85 (s, 2H), 1,12 - 0.98 (m, 4H);

1 ⁹ F NMR (376 MHz, Acetone-fc) δ -61.86, -71.70, -117.56, -123.10,

-128.52

^X H NMR (400 MHz, Acetone-cfe) δ 10.24 (s, IH), 9.49 (s, IH), 9.29

(s, IH), 8.15 - 8.00 (m, 2H), 7.87 - 7.78 (m, 3H), 7.53 - 7.43 (m, 2H), 7.15 (td, J ^~ 9.2, 1.9 Hz, IH), 4.67 (qd, J = 7.3, 5.8 Hz, IH), 4.11 (td, J = 7.8, 4.8 Hz,

ESIMS m/z 763 IH), 4.00 (td, J = 8,2, 6.3 Hz,

FI837

([M + H] ⁴ ) IH), 3,72 (d, J = 8.3 Hz, IH),

3.59 (td, J = 8.0, 5,9 Hz, IH), 3,45 (d, J = 8.3 Hz, IH), 2.54 (q, J ------ 7.0 Hz, IH), 2.35 - 2.21 (m,

IH);

¹⁹ F NMR (376 MHz, Acetone-cfe) δ -61.88, -78.06, -117.60, -123.49,

-128.83

*H NMR (400 MHz, Acetone- e) δ 10.20 (s, IH), 9.26 (s, IH), 8.02 fcl, J - 2.6 Hz, IH), 7.87 - 7.77 (m, 3H), 7.53 - 7.39 (m, 3H), 6.90 (ddd, J = 11,4, 9.0, 2,0 Hz,

IH), 4.53 (s, IH), 3.72 (d, J =

ESIMS m/z 639

F1838 8.3 Hz, IH), 3.44 (d, J = 8,3 Hz,

([M + H] ^"1" )

IH), 3,37 - 3.26 (m, 2H), 1.60 (h, J = 7.3 Hz, 2H), 0.94 (t, J -----

7.4 Hz, 3H);

1 ⁹ F NMR (376 MHz, Acetone-de) δ -61.88, -117.60, -133.95, -141.63

^J H NMR (400 MHz, Acetone-do) δ 10,25 (s, 2H), 9.58 (s, IH), 8.21 (td, J - 8.8, 5.6 Hz, IH), 8.05 (d, J = 2.6 Hz, IH), 7.83 (ddd, J = 11.4, 6.4, 1.8 Hz, 3H), 7.48 (t, J = 9,0 Hz, 2H), 7,24 (td, J = 9.3,

ESIMS m/z 775

F1839 2.0 Hz, IH), 6.26 - 5.95 (m, IH),

([M + H] ⁴ )

3.82 - 3.62 (m, IH), 3.45 (d, J =

8.3 Hz, IH);

1 ⁹ F NMR (376 MHz, Acetone-ce) δ -61.89, -74.91, -116.68, -117.57, -117.64, -121.04, -121.77, -123.34, -128.61, -128.73

*H NMR (400 MHz, DMSG-de) δ

10.96 (s, IH), 10.45 (s, IH), 10.17 (s, IH), 7.93 (d, J - 2.6 Hz, IH), 7.90 - 7.80 (m, 2H), 7,76 (dd, J = 8.8, 2,6 Hz, IH),

H RMS- ESI { /z)

7,69 - 7,52 (m, 3H), 7,21 (td, J = [M + ] ⁺ caicd for

128- 9.2, 1,7 Hz, IH), 3.69 (d, J = 8.4

F1850 C30H20CI3F6N3O4,

134 Hz, IH), 3.51 (d, J = 8.5 Hz, IH),

705.0424 found,

2,26 (s, 3H), 1.53 - 1.46 (m, 2H), 705.0416

1.46 - 1.40 (rrs, 2H);

1 ⁹ F NMR (376 MHz, DMSO-de) δ -59.92 (d, J = 12.8 Hz), -116,94 (q, J = 12.7 Hz), -120.74 (d, J - 3.4 Hz), -124.66 (d, J - 3.5 Hz)

*H NMR (400 MHz, Acetone-do) δ 10.19 (s, IH), 9.47 (s, IH), 9.03 (s, IH), 8.09 (td, J - 8.8, 5.6 Hz,

IH), 8,02 (d, J = 2.6 Hz, IH), 7.87 - 7,78 (m, 3H), 7,48 (dt, J =

ESIMS m/z 732 9,7, 5.4 Hz, 2H), 7.13 (td, J =

FI8S1

([M + H] ⁴ ) 9.2, 2,0 Hz, IH), 3.79 - 3.68 (rrt,

3H), 3,43 (d, J = 8.3 Hz, IH), 3,12 (t, J = 6.5 Hz, 2H); 1 ⁹ F NMR (376 MHz, Acetone-c/e) δ -61.88, -117.64, -122.98, -128,32

*H NMR (400 MHz, Acetorie-de) δ 10.21 (s, IH), 9,46 (s, IH), 9.02

(s, IH), 8.13 - 7.99 (m, 2H), 7.86 - 7.77 (m, 3H), 7.52 - 7.43 (m, 2H), 7.12 (td, J - 9.3, 1.9 Hz, IH), 4.62 (dp, J = 7,8, 6.6

ESIMS m/z 746

F1S53 Hz, IH), 3.71 (d, J = 8,3 Hz, IH),

([M + H] ⁴ )

3,43 (d, J = 8.3 Hz, IH), 3.09 (h, J = 8.9, 8,4 Hz, 2H), 1,80 (d, J =

6.7 Hz, 3H);

1 ⁹ F NMR (376 MHz, Acetone-de) δ -61.83, -117.59, -122,89, -128.28

^! H NMR (400 MHz, Acetone-de) δ 10,11 (s, IH), 9.38 (s, IH), 8.77

(s, IH), 8.03 - 7.89 (m, 2H), 7.78 - 7.68 (m, 3H), 7.39 (dd, J - 9.5, 6.9 Hz, 2H), 7.01 (td, J = 9.2, 2.0 Hz, IH), 3,62 (d, J = 8,3

ESIMS m/z 693 Hz, IH), 3,33 (d, J = 8.3 Hz, IH),

F1854

([M + H] ⁴ ) 2.46 (t, J = 7,4 Hz, 2H), 1,51 (q,

J = 7,3 Hz, 2H), 0,71 (tt, J = 7,6, 4,9 Hz, IH), 0,38 - 0.27 (m, 2H), -0.01 (dd, J = 4.9, 1.5 Hz, 2H); 1 ⁹ F NMR (376 MHz, Acetone-ce) δ -61.86, -117.61, -123.15, -128.65 ^X H NMR (400 MHz, Acetone-ofe) δ

10.20 (s, IH), 9.48 (s, IH), 9.08 (s, IH), 8.15 - 8.04 (m, IH), 8.03 (d, J - 2.6 Hz, IH), 7.83 (ddd, J = 8.4, 5.8, 2.5 Hz, 3H), 7,54 - 7,44 m _f 2H), 7.14 (dd, J

ESIMS m/z 678

F1855 = 10.3, 8.3 Hz, IH), 3.72 (d, J =

([M + H] ⁴ )

8.3 Hz, IH), 3.44 (d, J = 8,3 Hz, IH), 2,93 (t, J = 7.1 Hz, 2H), 2,80 (d, J = 6.9 Hz, 2H); 1 ⁹ F NMR (376 MHz, Acetone-cfe) δ -61.89, -117.63, -123.27, -128.48

^X H NMR (400 MHz, Acetone-cfe) δ 10,22 (s, IH), 9.48 (s, IH), 8.84

(s, IH), 8,11 - 7.98 (m, 2H), 7.82 (ddd, J - 11.4.7.1, 2.6 Hz. 3H), 7,48 (dd, J = 9.5, 6,8 Hz, 2H), 7.10 (td, J = 9,2, 1.9 Hz,

ESIMS m/z 723 IH), 3,71 (d, J = 8.3 Hz, IH),

F 1856

([M + H] ⁴ ) 3.43 (d, J = 8,3 Hz, IH), 2,44 (t,

J = 7.3 Hz, 2H), 1,69 (dtd, J = 15.1, 7.4, 4.3 Hz, 2H), 1.34 - 1.25 (m, 2H), 0.90 (s, 9H); 1 ⁹ F NMR (376 MHz, Acetone-cfe) δ -61.85, -117.57, -123.16, -128.68

*H NMR (400 MHz, Acetone-de) δ 10.23 (s, IH), 9.49 (s, IH), 9.01

(s, IH), 8.12 - 8.00 (m, 2H), 7.87 - 7.77 (m, 3H), 7.48 (dt, J -

9.9, 5.1 Hz, 2H), 7.12 (td, J = 9,3, 1,9 Hz, IH), 3.71 (d _f J = 8.3

ESIMS m/z 692

F1857 Hz, IH), 3.44 (d, J = 8.3 Hz, IH),

([M + H] ^"1" ) 2.67 (t, 3 - 7.2 Hz, 2H), 2,59 (t, J

= 7.2 Hz, 2H), 2.09 - 1,97 (m,

2H);

¹⁹ F NMR (376 MHz' Acetone-de) δ -61.86, -117.58, -123,18, -128.68

^J H NMR (400 MHz, Acetone-cfe) δ 10,21 (s, IH), 9.49 (s, IH), 9.10

(s, IH), 8.15 - 8.00 (m, 2H), 7,87 - 7,77 (m, 3H), 7.48 (dt, J -

9.8, 5,3 Hz, 2H), 7,13 (td, J =

ESIMS m/z 837 9.2, 1.9 Hz, IH), 3,72 (d, J = 8.3

F1858

([M + H] ⁴ ) Hz, IH), 3,44 (d, J = 8.3 Hz, IH),

2.89 (dd, J - 8,6, 5.8 Hz, 2H),

2.75 (dt, J = 15.7, 7.5 Hz, 2H); 1 ⁹ F NMR (376 MHz, Acetone-/ ^' s) δ -53.91, -61.86, -83.72, -117.59, -123.23, -128.61, -130.79 ^l NMR (400 MHz, DMSG-de) δ

10.95 (s, 1H), 10.44 (s, 1H), 9.96 (s, 1H), 7.92 (d, 3 - 2.6 Hz, IH), 7.76 (dd, J = 8.8, 2.6 Hz, IH), 7,71 (dd, 3 = 7.2, 1.9 Hz, IH), 7.63 (td, J = 8.7, 5.6 Hz, IH), 7.55 (d, J = 8.8 Hz, IH), 7.51 -

ESIMS m/z 700 7.40 (m, 2H), 7.24 - 7,15 (m,

F1866

([M + H]-) IH), 3.59 (d,J = 8,4 Hz, IH),

3.44 (d, J = 8.4 Hz, IH), 2.93 (td, J = 8,3, 6.9, 4,1 Hz, IH), 2.79 - 2,59 (m, IH), 2.46 - 2.29 (m, IH), 1.25 (d, 3 - 7.1 Hz, 3H); 1 ⁹ F NMR (376 MHz, DMSO-de) δ -63.57, -117.29, -121.06, -124.87

^■ NMR (400 MHz, DMSO-de) δ 10.96 (s, IH), 10.46 (s, IH), 9.84 (s, IH), 7.93 (d, J = 2.5 Hz, IH), 7.75 (dd, J = 8.8, 2.6 Hz, IH), 7.71 (dd, 3 = 7,3, 1.9 Hz, IH), 7,65 (td, 3 = 8.7, 5,7 Hz, IH),

ESIMS m/z 702 7,56 (d,J = 8.8 Hz, IH), 7.52 -

FI867

([M + H] ^" ) 7,41 (m, 2H), 7.26 - 7,17 (m,

IH), 4.38 (s, 2H), 4.25 (q, J = 9.3 Hz, 2H), 3.59 (d, J - 8.4 Hz, IH), 3.44 (d, 3 = 8.5 Hz, IH); 1 ⁹ F NMR (376 MHz, DMSO-d ₆ ) δ -72.91, -117.28, -120.42, -124.26

*H NMR (400 MHz, Acetone-de) δ 10.19 (s, IH), 9.47 (s, IH), 8.87 (s, IH), 8.07 (td, J = 8.7, 5,6 Hz,

IH), 8,01 (d, J = 2,6 Hz, IH), 7,87 - 7,77 (m, 3H), 7.53 - 7,43 (rrt, 2H), 7.11 (td, 3 = 9,3, 2,0

ESIMS m/z 665 Hz, IH), 6,94 (dq, J = 15.4, 6.9

F1868

([M + H] ^" ) Hz, IH), 6,25 (dq, J = 15.2, 1.7

Hz, IH), 3.71 (d, J = 8.3 Hz, IH), 3.42 (d, 3 - 8.3 Hz, IH), 1.89 (dd, 3 - 6.9, 1.7 Hz, 3H); 1 ⁹ F NMR (376 MHz, Acetone-cfc) δ -61.87, -117.60, -123,07, -128.56

⁵ H NMR (400 MHz, Acetone-ds) δ

10.18 (s, IH), 9.53 (d, J = 9.9 Hz, 2H), 8.12 (td, J = 8.8, 5.6 Hz,

IH), 8,04 (d, 3 = 2.6 Hz, IH), 7,86 - 7.76 (m, 3H), 7,47 (dt, 3 =

ESIMS m/z 719 9.7, 5,2 Hz, 2H), 7.21 - 7.06 (rrt,

FI869

([M + H] ⁺ ) 2H), 6,96 (dq, 3 = 15.5, 6,7 Hz,

IH), 3,71 (d, J = 8.3 Hz, IH), 3,43 (d, 3 - 8.3 Hz, IH); 1 ⁹ F NMR (376 MHz, Acetone-de) δ -61.83, -65.68, -117.55, -122.71,

-128.05

^J H INiMR (400 MHz, Acetone-de) δ

10, 13 (s, IH), 8.31 - 8. 17 (m, 1H), 7.78 (d, J - 2, 5 Hz, IH), 7.66 (dd, J - 8.8, 2, 6 Hz, IH),

7.60 - 7.49 (m, IH), 7.42 (dd, J

ESIMS /z 537 = 22.1, 8,8 Hz, IH), 7,21 (dtd, J

F2010

( [M + H] ⁺ ) = 17.6, 8,7, 1.9 Hz, IH), 4.18

(qd, J = 9.6, 6, 0 Hz, 2H), 3,44 (dd, J = 11 , 1, 1.8 Hz, I H), 3.28 (d, J = 11.0 Hz, IH) ;

i ⁵ F NMR (376 MHz, Acetone-de) δ -72.55, - 112.61, -115.81

^J H NMR (400 MHz, Acetone-de) δ 10.23 (s, IH), 8,24 (t, J = 6.4 Hz, IH), 7.92 (d, J - 2.6 Hz, IH), 7.78 (dd, J - 8,7, 2.6 Hz, IH),

ESIMS m/z 537 7.50 - 7.37 (m, 2H), 7.25 (td, J =

F2011

([M + H] ⁺ ) 8.7, 1.9 Hz, IH), 4.20 (ttd, J =

9.5, 6.4, 3.2 Hz, 2H), 3.63 - 3.55 (m, IH), 3.36 (d, J = 8.2 Hz, IH) ; 1 ⁹ F NMR (376 MHz, Acetone-de) δ -72.60, - 114.47, -115 , 17

Ή N R (400 MHz, Acetone-de) δ 10.19 (s, IH), 8,24 (t, J = 6.5 Hz, H), 7,98 (dd, J = 6.4, 2, 2 Hz,

IH), 7,92 (d, J = 2.5 Hz, IH),

ESIMS m/z 587 7.85 - 7.74 (m, 2H), 7.46 (d, J =

F20I2

([M + H] ⁺ ) S.7 Hz, IH), 4.20 (qd, J ------ 9.5,

6.5 Hz, 2H), 3.70 (d, J - 8, 1 Hz,

IH), 3.53 (d, J - 8.2 Hz, IH) ; i ⁹ F NMR (376 MHz, Acetone-de) δ -62.65, -72,61, - 111.91

^¾ H NMR (400 MHz, Acetone-de) δ 10, 15 (s, IH), 8.19 (t, J = 6.5 Hz,

IH) , 7,93 - 7.85 (m, 2H), 7.75 (d, J = 2,6 Hz, IH), 7,67 (dd, J = 8.8, 2.7 Hz, IH), 7.41 (d, J - 8.7

ESIMS m/z 587

F2013 Hz, I H), 4. 17 (qdd, J - 9.5, 6.5,

( [M + HD

1.6 Hz, 2H), 3.57 (dd, 3 = 10,9, 1 ,2 Hz, IH), 3,36 (d, J = 11.0 Hz,

IH) ;

¹⁹ F NMR (376 MHz, Acetone-de) δ -62.68, -72.60, - 109.42

^J H NMR (400 MHz, Acetone-de) δ 10.14 (s, IH), 8,23 (t, J - 6.5 Hz,

IH), 7.92 (d, J - 2.6 Hz, IH), 7.74 (ddd, J - 26.9, 7.8, 2.4 Hz, 2H), 7,61 (dd, J = 6.4, 2, 2 Hz,

ESIMS m/z 566 IH), 7,45 (d, J = 8.7 Hz, IH),

F2014

([M + H] ⁴ ) 4.20 (qd, J = 9, 5, 6.5 Hz, 2H),

3,65 (d, J = 8.3 Hz, H), 3.40 (d, J - 8.3 Hz, IH), 2.38 (d, J = 2,2

Hz, 3H) ;

i ⁹ F NMR (376 MHz, Acetone-de) δ -61.85, -72.62, - 121.65 *H NMR (400 MHz, DMSG-cfe) δ

10.87 (s, 1 H), 9.83 (d, J - 5.9 Hz, 1 H), 7.80 - 7.68 (m, 2H),

7.63 (t, J - 1.9 Hz, 1 H), 7.49 (d, J = 8.5 Hz, 1 H), 5.20 (dd, J =

ESIMS m/z 583 6.0, 3.5 Hz, 1H), 3.62 (d, J = 8.5

F2569

([M-H]-) Hz, 1H), 3.50 (d, J = 8.5 Hz, 1H),

3.09 (s, 1H), 2.18 - 2 ,00 (m,

1H), 1.88 - 1.73 (m, 6H), 1.71 -

1.51 (m, 3H) ;

1 ⁹ F NMR (376 M Hz, DMSG-cfe) δ

-94.82

*H NMR (400 MHz, DMSO-de) δ 10.84 (s, 1 H), 9.86 (d, J = 6.1 Hz, 1H), 7.71 (d, J - 2.6 Hz, 1H), 7.67 - 7.61 (m, 2H), 7.55 (cl, J = 1.9 Hz, 2H), 7.49 - 7.36 (m, 3H),

ESIMS m/z 575

F2570 7.20 - 7.10 (m, 2H), 5.58 (q, J =

([M + H] ⁺ )

5.4 Hz, 1H), 3,97 (d, J = 5.0 Hz, 2H), 3,62 (d, J = 8.5 Hz, 1H),

3.49 (d, J = 8, 5 Hz, 1 H) ; 1 ⁹ F NMR (376 M Hz, DMSO-de) δ

- 116.09

H NMR (400 MHz, DMSO-cfe) δ 10,92 (s, 1H), 10,44 (d, J = 2, 0 Hz, 1H), 8.71 (d, J = 2.1 Hz, 1H),

7.88 (d, J = 2, 5 Hz, 1H), 7, 78 (dd, J = 8.8, 2.6 Hz, 1H), 7.63 (t,

ESIMS m/z 609 J - 1.9 Hz, 1H), 7.58 - 7.54 (rr>,

F2571

([M-H] ^" ) 3H), 7.53 (d, J ^~ 8.5 Hz, 2H),

6.94 (d, J - 8.5 Hz, 2H), 3.64 (d, J = 8.5 Hz, 1H), 3.53 (d, J = 8.5

Hz, 1H) ;

1 ⁹ F NMR (376 M Hz, DMSO-cfe) δ

-59.32

^' Ή NMR (400 MHz, DMSO-de) δ 10.93 (s, 1H), 10.43 (d, J = 2.4 Hz, 1H), 8.54 (d, J = 2.4 Hz, 1H),

7,88 (d, J = 2,6 Hz, 1H), 7, 76 (dd, J = 8.8, 2.6 Hz, 1H), 7.63 (t,

ESIMS m/z 609 J = 1.9 Hz, 1H), 7.58 - 7, 53 (m,

F2572

([M-H] ^" ) 3H), 7.42 (t, J - 7.9 Hz, 1H),

7. 13 (d, J ^~ 2.0 Hz, 1 H), 7.07 (t, J - 9.1 Hz, 2H), 3.64 (d, J - 8.4 Hz, 1 H), 3.52 (d, J = 8, 5 Hz, 1H) ; 1 ⁹ F NMR (376 M Hz, DMSO-de) δ

-61.38 ^l !NMR (400 MHz, DMSO-de) δ

10.80 (s, 1 H), 7.70 (d, J - 2.4 Hz, 1 H), 7.64 - 7.60 (rr>, 1H), 7.59 (d, J - 2.8 Hz, 1H), 7.54 (d, J = 1.6 Hz, 2H), 7.44 (d, J = 8.8

99- ESIMS m/z 573.8

F3009 Hz, 1H), 7,23 (t, J = 5.2 Hz, 1 H),

101 ([M + H]÷)

3.59 (d, J = 8.4 Hz, 1H), 3.48 (d, J = 8,4 Hz, 1 H), 3 ,36 (s, 3H),

3,24 - 3.14 (m, 2H) ;

1 ⁹ F IMMR (376 M Hz, DMSG-cfe) δ

-62.95

*H NMR (400 MHz, DMSO-de) δ rotamers 10.86 (s, 0.7H), 10.80 (s, 0.3H), 10.76 (s, 0.3H), 10.65

(s, 0.7H), 7.77 (d, J - 2.5 Hz, 0.7H), 7.73 (dd, J ^~ 8.7, 2.6 Hz, 0.7H), 7.67 (d, J - 2.5 Hz, 0.3H), 7,62 (d, J = 1.9 Hz, 1H), 7.60 (d,

J = 2.5 Hz, 0.3H), 7.55 (d, J = 1.8 Hz, 2H), 7, 50 (d, J = 8.7 Hz,

ESIMS m/z 505

F30I0 0.7H), 7 ,44 (d, J = 8.7 Hz, 0.3H),

( [M-H]-)

3.67 - 3, 56 (m, 1 H), 3, 55 - 3.45

(in, 1H), 1.99 (s, 2H), 1.90 (s,

2H), 1.89 (s, 1H), 1.74 (s, 1H) .

¹³ C NMR ( 151 MHz, DMSO-cfs) δ 163.05, 162.54, 159.82, 138.04, 137.77, 136.70, 134.53, 130.56, 128.39, 128.17, 124.97, 120.03, 38.89, 37.24, 25.53, 18 , 56,

17,81

fable 6; i Anal tic* a! data for molecules in Tab!e i

Table ABC: Biological Results

985

986

987

988

989

990

991

992

993

994

995

996

997

998

999

1000

1001

1002

1003

1004

1005

1006

1007

1008

1009