Title:
MOLECULES WHICH BIND CLEC9A
Document Type and Number:
WIPO Patent Application WO/2013/053008
Kind Code:
A3
Abstract:
The present invention relates to the identification of molecules which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T-cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.
Inventors:
COLMAN PETER MALCOLM (AU)
COPPEL ROSS LEON (AU)
CZABOTAR PETER EDWARD (AU)
LAHOUD MIREILLE HANNA (AU)
NICOLA NICOS ANTHONY (AU)
POLICHENI ANTONIA NATALIE (AU)
SHORTMAN KENNETH DOUGLAS (AU)
TULLETT KIRSTEEN MCINNES (GB)
ZHANG JIAN-GUO (AU)
BAUM JACOB (AU)
WONG WILSON (AU)
COPPEL ROSS LEON (AU)
CZABOTAR PETER EDWARD (AU)
LAHOUD MIREILLE HANNA (AU)
NICOLA NICOS ANTHONY (AU)
POLICHENI ANTONIA NATALIE (AU)
SHORTMAN KENNETH DOUGLAS (AU)
TULLETT KIRSTEEN MCINNES (GB)
ZHANG JIAN-GUO (AU)
BAUM JACOB (AU)
WONG WILSON (AU)
Application Number:
PCT/AU2012/001233
Publication Date:
June 20, 2013
Filing Date:
October 12, 2012
Export Citation:
Assignee:
INST MEDICAL W & E HALL (AU)
International Classes:
C07K14/435; A61K38/17; A61P37/00; C12N5/0784; C12N15/12
Domestic Patent References:
| WO2010108215A1 | 2010-09-30 |
Other References:
NESTOR, M. W. ET AL.: "The Actin Binding Domain of betal-Spectrin Regulates the Morphological and Functional Dynamics of Dendritic Spines", PLOS ONE, vol. 6, no. ISS. 1, January 2011 (2011-01-01), pages E16197, XP055071897
HOWARD, T. ET AL.: "The 47-kD Protein Increased in Neutrophil Actin Dysfunction With 47- and 89-kD Protein Abnormalities Is Lymphocyte-Specific Protein", BLOOD, vol. 83, no. 1, January 1994 (1994-01-01), pages 231 - 241
SANCHO, D. ET AL.: "Identification of a dendritic cell receptor that couples sensing of necrosis to immunity", NATURE, vol. 458, no. 7240, April 2009 (2009-04-01), pages 899 - 903, XP002693445
ZHANG, J.-G. ET AL.: "The Dendertic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments", IMMUNITY, vol. 36, no. ISS. 4, April 2012 (2012-04-01), pages 646 - 657, XP002693452
AHRENS, S. ET AL.: "F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells", IMMUNITY, vol. 36, no. ISSUE, April 2012 (2012-04-01), pages 635 - 645, XP002693451
HOWARD, T. ET AL.: "The 47-kD Protein Increased in Neutrophil Actin Dysfunction With 47- and 89-kD Protein Abnormalities Is Lymphocyte-Specific Protein", BLOOD, vol. 83, no. 1, January 1994 (1994-01-01), pages 231 - 241
SANCHO, D. ET AL.: "Identification of a dendritic cell receptor that couples sensing of necrosis to immunity", NATURE, vol. 458, no. 7240, April 2009 (2009-04-01), pages 899 - 903, XP002693445
ZHANG, J.-G. ET AL.: "The Dendertic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments", IMMUNITY, vol. 36, no. ISS. 4, April 2012 (2012-04-01), pages 646 - 657, XP002693452
AHRENS, S. ET AL.: "F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells", IMMUNITY, vol. 36, no. ISSUE, April 2012 (2012-04-01), pages 635 - 645, XP002693451
Attorney, Agent or Firm:
MONGER, Carmela (1G Royal Parade Parkvill, Melbourne Victoria 3052, AU)
Download PDF:
Previous Patent: SYSTEM AND METHOD FOR ANALYSING A HETEROGENEOUS, THREE-DIMENSIONAL OBJECT HAVING AN AMORPHOUS SHAPE
Next Patent: A CONTAINER
Next Patent: A CONTAINER