Title:
MONOAMINE OXIDASE B IMAGING PROBE
Document Type and Number:
WIPO Patent Application WO/2020/032038
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I), which has high specificity and high selectivity for monoamine oxidase B, and which is capable of imaging monoamine oxidase B with a good sensitivity, or a pharmaceutically acceptable salt or solvate of this compound.
Inventors:
HARADA RYUICHI (JP)
FURUMOTO SHOZO (JP)
KUDO YUKITSUKA (JP)
OKAMURA NOBUYUKI (JP)
FURUMOTO SHOZO (JP)
KUDO YUKITSUKA (JP)
OKAMURA NOBUYUKI (JP)
Application Number:
PCT/JP2019/030936
Publication Date:
February 13, 2020
Filing Date:
August 06, 2019
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07D401/04; A61K51/04; A61P21/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07B53/00; C07B59/00
Domestic Patent References:
| WO2017103257A1 | 2017-06-22 | |||
| WO2015060365A1 | 2015-04-30 | |||
| WO2012057312A1 | 2012-05-03 | |||
| WO2015060365A1 | 2015-04-30 | |||
| WO2017103257A1 | 2017-06-22 | |||
| WO2017103257A1 | 2017-06-22 |
Foreign References:
| JP2012521988A | 2012-09-20 |
Other References:
MATHIS ET AL., SEMIN NUCL MED., vol. 47, no. 5, 2017, pages 553 - 575
TONG ET AL., J CEREB BLOOD FLOW METAB., vol. 33, no. 6, 2013, pages 863 - 871
TONG ET AL., BRAIN, vol. 140, no. 9, 2017, pages 2460 - 2474
PEKNY ET AL., ACTA NEUROPATHOL, vol. 131, 2016, pages 323 - 345
EKBLOM ET AL., GLIA, vol. 8, 1993, pages 122 - 132
OKAMURA ET AL., CLIN TRANSL IMAGING, vol. 8, 2018, pages 122 - 132
GULYAS ET AL., NEUROCHEM INT, vol. 58, no. 1, 2011, pages 60 - 68
BLOM E ET AL.: "Synthesis and In vitro evaluation of F-β-carboline alkaloids as PET ligands", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 51, 2008, pages 27 - 282, XP002528623, DOI: 10.1002/jlcr.1519
HARADA R ET AL.: "FTHK-5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease", JOURNAL OF NUCLEAR MEDICINE, vol. 57, no. 2, 2016, pages 208 - 214
See also references of EP 3835293A4
TONG ET AL., J CEREB BLOOD FLOW METAB., vol. 33, no. 6, 2013, pages 863 - 871
TONG ET AL., BRAIN, vol. 140, no. 9, 2017, pages 2460 - 2474
PEKNY ET AL., ACTA NEUROPATHOL, vol. 131, 2016, pages 323 - 345
EKBLOM ET AL., GLIA, vol. 8, 1993, pages 122 - 132
OKAMURA ET AL., CLIN TRANSL IMAGING, vol. 8, 2018, pages 122 - 132
GULYAS ET AL., NEUROCHEM INT, vol. 58, no. 1, 2011, pages 60 - 68
BLOM E ET AL.: "Synthesis and In vitro evaluation of F-β-carboline alkaloids as PET ligands", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 51, 2008, pages 27 - 282, XP002528623, DOI: 10.1002/jlcr.1519
HARADA R ET AL.: "FTHK-5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease", JOURNAL OF NUCLEAR MEDICINE, vol. 57, no. 2, 2016, pages 208 - 214
See also references of EP 3835293A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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