Title:
MONOBODY AND NK CELLS
Document Type and Number:
WIPO Patent Application WO/2024/048575
Kind Code:
A1
Abstract:
The present invention provides a novel substance that stably binds to a surface protein which is expressed in NK cells. The present invention provides a monobody that binds to a surface protein of NK cells and that has any one of amino acid sequences (1) to (3): (1) an amino acid sequence represented by any one of SEQ ID NOs: A1-A12; (2) an amino acid sequence in which, in an amino acid sequence represented by any one of SEQ ID NOs: A1-A12, a deletion, substitution, and/or addition of one or more amino acids is made to an amino acid sequence other than an arbitrary amino acid; and (3) an amino acid sequence having not less than 80% sequence identity with an amino acid sequence other than an arbitrary amino acid sequence, in the amino acid sequence represented by any one of SEQ ID NOs: A1-A12 (in SEQ ID NOs: A1-A12, X1, X2, X3, X4, X5 and X6 are each independently an arbitrary amino acid, and n1, n2, n3, n4, n5 and n6 each independently represent an arbitrary natural number).
Inventors:
HARADA YUI (JP)
YONEMITSU YOSHIKAZU (JP)
MURAKAMI HIROSHI (JP)
HAYASHI GOSUKE (JP)
FUJINO TOMOSHIGE (JP)
TANAKA CHIHIRO (JP)
YONEMITSU YOSHIKAZU (JP)
MURAKAMI HIROSHI (JP)
HAYASHI GOSUKE (JP)
FUJINO TOMOSHIGE (JP)
TANAKA CHIHIRO (JP)
Application Number:
PCT/JP2023/031204
Publication Date:
March 07, 2024
Filing Date:
August 29, 2023
Export Citation:
Assignee:
GAIA BIOMEDICINE INC (JP)
International Classes:
C12N15/13; C07K16/28; C12N5/0783
Domestic Patent References:
| WO2021212638A1 | 2021-10-28 |
Foreign References:
| US20220135678A1 | 2022-05-05 |
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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