MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN

Title:

MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN

Document Type and Number:

WIPO Patent Application WO/2012/006500

Kind Code:

A3

Abstract:

The present disclosure relates to anti-HCV core protein monoclonal antibodies, methods of making them, and their uses in the prevention, diagnosis, and/or treatment of disease including HCV infections.

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Inventors:

MUERHOFF ANTHONY SCOTT (US)
BROPHY SUSAN E (US)
ZECK BILL J (US)

Application Number:

PCT/US2011/043311

Publication Date:

April 12, 2012

Filing Date:

July 08, 2011

Export Citation:

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Assignee:

ABBOTT LAB (US)
MUERHOFF ANTHONY SCOTT (US)
BROPHY SUSAN E (US)
ZECK BILL J (US)

International Classes:

C07K16/10

Domestic Patent References:

WO2008070727A2	2008-06-12
WO2008024188A2	2008-02-28
WO2001096875A2	2001-12-20

Foreign References:

EP1308507A2

2003-05-07

Other References:

MUERHOFF A S ET AL: "Microheterogeneous monoclonal antibody subspecies with differential hepatitis C virus core antigen binding properties identified by SEC-HPLC", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 345, no. 1-2, 30 June 2009 (2009-06-30), pages 60 - 69, XP026132876, ISSN: 0022-1759, [retrieved on 20090416], DOI: 10.1016/J.JIM.2009.04.004
WANG Y T ET AL: "Potential of mean force of the hepatitis C virus core protein-monoclonal 19D9D6 antibody interaction", BIOPHYSICAL CHEMISTRY, NORTH-HOLLAND, AMSTERDAM, NL, vol. 145, no. 2-3, 1 December 2009 (2009-12-01), pages 86 - 90, XP026709025, ISSN: 0301-4622, [retrieved on 20090922], DOI: 10.1016/J.BPC.2009.09.004

Attorney, Agent or Firm:

BECKER, Cheryl L. et al. (100 Abbott Park RoadAbbott Park, Illinois, US)

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